Janelle Ayres

Title(s)Adjunct Professor, Cell and Developmental Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Host-microbe interactions: Harnessing co-evolution to treat disease
    NIH DP1AI144249Sep 30, 2018 - Jul 31, 2023
    Role: Principal Investigator
    Tolerance defenses in host-microbiota interactions
    NIH R01AI114929May 10, 2015 - Mar 31, 2026
    Role: Principal Investigator
    Control of intestinal microflora and inflammation by immune sensing of flagellin
    NIH F32AI091068Jul 1, 2010 - Jun 30, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Fluoxetine promotes IL-10-dependent metabolic defenses to protect from sepsis-induced lethality. Sci Adv. 2025 Feb 14; 11(7):eadu4034. Gallant RM, Sanchez KK, Joulia E, Snyder JM, Metallo CM, Ayres JS. PMID: 39951524; PMCID: PMC11827869.
      View in: PubMed   Mentions:    Fields:    
    2. Host-encoded antivirulence defenses: host physiologies teach pathogens to play nice. Curr Opin Immunol. 2024 Dec; 91:102472. Ayres JS. PMID: 39383570.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Fluoxetine promotes immunometabolic defenses to mediate host-pathogen cooperation during sepsis. bioRxiv. 2023 Nov 18. Gallant RM, Snyder JM, Ayres JS. PMID: 38013994; PMCID: PMC10680848.
      View in: PubMed   Mentions:
    4. Paired microbiome and metabolome analyses associate bile acid changes with colorectal cancer progression. Cell Rep. 2023 08 29; 42(8):112997. Fu T, Huan T, Rahman G, Zhi H, Xu Z, Oh TG, Guo J, Coulter S, Tripathi A, Martino C, McCarville JL, Zhu Q, Cayabyab F, Low B, He M, Xing S, Vargas F, Yu RT, Atkins A, Liddle C, Ayres J, Raffatellu M, Dorrestein PC, Downes M, Knight R, Evans RM. PMID: 37611587; PMCID: PMC10903535.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    5. CD4+ T cells regulate sickness-induced anorexia and fat wasting during a chronic parasitic infection. Cell Rep. 2023 08 29; 42(8):112814. Redford SE, Varanasi SK, Sanchez KK, Thorup NR, Ayres JS. PMID: 37490905.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    6. Cooperation between physiological defenses and immune resistance produces asymptomatic carriage of a lethal bacterial pathogen. Sci Adv. 2023 06 23; 9(25):eadg8719. Chen GY, Thorup NR, Miller AJ, Li YC, Ayres JS. PMID: 37352357; PMCID: PMC10289649.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    7. Cachexia: A systemic consequence of progressive, unresolved disease. Cell. 2023 04 27; 186(9):1824-1845. Ferrer M, Anthony TG, Ayres JS, Biffi G, Brown JC, Caan BJ, Cespedes Feliciano EM, Coll AP, Dunne RF, Goncalves MD, Grethlein J, Heymsfield SB, Hui S, Jamal-Hanjani M, Lam JM, Lewis DY, McCandlish D, Mustian KM, O'Rahilly S, Perrimon N, White EP, Janowitz T. PMID: 37116469; PMCID: PMC11059056.
      View in: PubMed   Mentions: 32     Fields:    
    8. Age-dependent roles of cardiac remodeling in sepsis defense and pathogenesis. bioRxiv. 2023 Mar 15. Sanchez KK, McCarville JL, Stengel SJ, Snyder JM, Williams AE, Ayres JS. PMID: 36993409; PMCID: PMC10055033.
      View in: PubMed   Mentions:
    9. Cooperation between physiological defenses and immune resistance produces asymptomatic carriage of a lethal bacterial pathogen. bioRxiv. 2023 Feb 26. Chen GY, Thorup NR, Miller AJ, Li YC, Ayres JS. PMID: 36711884; PMCID: PMC9882269.
      View in: PubMed   Mentions:
    10. Chronic Leptin Deficiency Improves Tolerance of Physiological Damage and Host-Pathogen Cooperation during Yersinia pseudotuberculosis Infection. Infect Immun. 2022 09 15; 90(9):e0024222. Sanchez KK, Troha K, Mu A, Redford SE, McCarville JL, Insenga A, Stengel S, Lee YM, Ayres JS. PMID: 35924898; PMCID: PMC9476980.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. Virulence triggered allergies: Pseudomonas gets the Las laugh. Immunity. 2022 05 10; 55(5):824-826. McCarville JL, Ayres JS. PMID: 35545032.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    12. Adipose triglyceride lipase mediates lipolysis and lipid mobilization in response to iron-mediated negative energy balance. iScience. 2022 Mar 18; 25(3):103941. Romero AR, Mu A, Ayres JS. PMID: 35265813; PMCID: PMC8899412.
      View in: PubMed   Mentions: 3  
    13. Cooperative defenses during enteropathogenic infection. Curr Opin Microbiol. 2022 02; 65:123-130. Troha K, Ayres JS. PMID: 34847524; PMCID: PMC8818259.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    14. Microbiota control of maternal behavior regulates early postnatal growth of offspring. Sci Adv. 2021 01; 7(5). Lee YM, Mu A, Wallace M, Gengatharan JM, Furst AJ, Bode L, Metallo CM, Ayres JS. PMID: 33514556; PMCID: PMC7846171.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    15. Beyond tug-of-war: Iron metabolism in cooperative host-microbe interactions. PLoS Pathog. 2020 08; 16(8):e1008698. Chen GY, Ayres JS. PMID: 32785251; PMCID: PMC7423093.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    16. A metabolic handbook for the COVID-19 pandemic. Nat Metab. 2020 07; 2(7):572-585. Ayres JS. PMID: 32694793; PMCID: PMC7325641.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansPHPublic Health
    17. Surviving COVID-19: A disease tolerance perspective. Sci Adv. 2020 05; 6(18):eabc1518. Ayres JS. PMID: 32494691; PMCID: PMC7190329.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCellsPHPublic Health
    18. Microbiota Metabolites in Health and Disease. Annu Rev Immunol. 2020 04 26; 38:147-170. McCarville JL, Chen GY, Cuevas VD, Troha K, Ayres JS. PMID: 32340573.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimals
    19. The Biology of Physiological Health. Cell. 2020 04 16; 181(2):250-269. Ayres JS. PMID: 32302569; PMCID: PMC7409982.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    20. Immunometabolism of infections. Nat Rev Immunol. 2020 02; 20(2):79-80. Ayres JS. PMID: 31892735.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    21. Metabolic Adaptations to Infections at the Organismal Level. Trends Immunol. 2020 02; 41(2):113-125. Troha K, Ayres JS. PMID: 31959515; PMCID: PMC7409656.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    22. Host-Pathogen Relationship Advice: Fat Protects against a Broken Heart. Cell Metab. 2019 09 03; 30(3):409-411. McCarville JL, Ayres JS. PMID: 31484052.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    23. Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues. Nat Chem Biol. 2018 11; 14(11):1021-1031. Wallace M, Green CR, Roberts LS, Lee YM, McCarville JL, Sanchez-Gurmaches J, Meurs N, Gengatharan JM, Hover JD, Phillips SA, Ciaraldi TP, Guertin DA, Cabrales P, Ayres JS, Nomura DK, Loomba R, Metallo CM. PMID: 30327559; PMCID: PMC6245668.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    24. Cooperative Metabolic Adaptations in the Host Can Favor Asymptomatic Infection and Select for Attenuated Virulence in an Enteric Pathogen. Cell. 2018 09 20; 175(1):146-158.e15. Sanchez KK, Chen GY, Schieber AMP, Redford SE, Shokhirev MN, Leblanc M, Lee YM, Ayres JS. PMID: 30100182; PMCID: PMC6447043.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    25. When the Gut Gets Tough, the Enterocytes Get Going. Immunity. 2018 05 15; 48(5):837-839. Chen GY, Ayres JS. PMID: 29768167.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    26. Decoding the intestinal epithelium cell by cell. Nat Immunol. 2018 01; 19(1):7-9. Lee YM, Ayres JS. PMID: 29242547.
      View in: PubMed   Mentions: 2     Fields:    
    27. Disease tolerance: concept and mechanisms. Curr Opin Immunol. 2018 02; 50:88-93. McCarville JL, Ayres JS. PMID: 29253642; PMCID: PMC5884632.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    28. Resistance and tolerance defenses in cancer: Lessons from infectious diseases. Semin Immunol. 2017 08; 32:54-61. Rao S, Ayres JS. PMID: 28865876.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    29. NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8. Immunity. 2017 04 18; 46(4):649-659. Rauch I, Deets KA, Ji DX, von Moltke J, Tenthorey JL, Lee AY, Philip NH, Ayres JS, Brodsky IE, Gronert K, Vance RE. PMID: 28410991; PMCID: PMC5476318.
      View in: PubMed   Mentions: 201     Fields:    Translation:AnimalsCells
    30. Pathogen-Mediated Inhibition of Anorexia Promotes Host Survival and Transmission. Cell. 2017 01 26; 168(3):503-516.e12. Rao S, Schieber AMP, O'Connor CP, Leblanc M, Michel D, Ayres JS. PMID: 28129542; PMCID: PMC5324724.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    31. Microbes Dress for Success: Tolerance or Resistance? Trends Microbiol. 2017 01; 25(1):1-3. Ayres JS. PMID: 27894645.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    32. Thermoregulation as a disease tolerance defense strategy. Pathog Dis. 2016 12; 74(9). Schieber AM, Ayres JS. PMID: 27815313; PMCID: PMC5975229.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    33. Disease Tolerance Trick or Treat: Give Your Brain Something Good to Eat. Cell. 2016 Sep 08; 166(6):1368-1370. Ayres JS. PMID: 27610563.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. Cooperative Microbial Tolerance Behaviors in Host-Microbiota Mutualism. Cell. 2016 Jun 02; 165(6):1323-1331. Ayres JS. PMID: 27259146; PMCID: PMC4903080.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimals
    35. Neuronal energy-sensing pathway promotes energy balance by modulating disease tolerance. Proc Natl Acad Sci U S A. 2016 Jun 07; 113(23):E3307-14. Shen R, Wang B, Giribaldi MG, Ayres J, Thomas JB, Montminy M. PMID: 27208092; PMCID: PMC4988575.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    36. Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling. Science. 2015 Oct 30; 350(6260):558-63. Schieber AM, Lee YM, Chang MW, Leblanc M, Collins B, Downes M, Evans RM, Ayres JS. PMID: 26516283; PMCID: PMC4732872.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    37. Inflammasome-microbiota interplay in host physiologies. Cell Host Microbe. 2013 Nov 13; 14(5):491-7. Ayres JS. PMID: 24237695.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    38. The ubiquitin ligase parkin mediates resistance to intracellular pathogens. Nature. 2013 Sep 26; 501(7468):512-6. Manzanillo PS, Ayres JS, Watson RO, Collins AC, Souza G, Rae CS, Schneider DS, Nakamura K, Shiloh MU, Cox JS. PMID: 24005326; PMCID: PMC3886920.
      View in: PubMed   Mentions: 312     Fields:    Translation:AnimalsCells
    39. Recognition of bacteria by inflammasomes. Annu Rev Immunol. 2013; 31:73-106. von Moltke J, Ayres JS, Kofoed EM, Chavarría-Smith J, Vance RE. PMID: 23215645.
      View in: PubMed   Mentions: 213     Fields:    Translation:HumansAnimalsCells
    40. Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota. Nat Med. 2012 May; 18(5):799-806. Ayres JS, Trinidad NJ, Vance RE. PMID: 22522562; PMCID: PMC3472005.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    41. Cellular teamwork in antibacterial innate immunity. Nat Immunol. 2012 Jan 19; 13(2):115-7. Ayres JS, Vance RE. PMID: 22261960.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    42. The circadian clock protein timeless regulates phagocytosis of bacteria in Drosophila. PLoS Pathog. 2012 Jan; 8(1):e1002445. Stone EF, Fulton BO, Ayres JS, Pham LN, Ziauddin J, Shirasu-Hiza MM. PMID: 22253593; PMCID: PMC3257305.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    43. Tolerance of infections. Annu Rev Immunol. 2012; 30:271-94. Ayres JS, Schneider DS. PMID: 22224770.
      View in: PubMed   Mentions: 214     Fields:    Translation:HumansAnimals
    44. The role of anorexia in resistance and tolerance to infections in Drosophila. PLoS Biol. 2009 Jul; 7(7):e1000150. Ayres JS, Schneider DS. PMID: 19597539; PMCID: PMC2701602.
      View in: PubMed   Mentions: 146     Fields:    Translation:AnimalsCells
    45. A signaling protease required for melanization in Drosophila affects resistance and tolerance of infections. PLoS Biol. 2008 Dec 09; 6(12):2764-73. Ayres JS, Schneider DS. PMID: 19071960; PMCID: PMC2596860.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    46. Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases. Nat Rev Immunol. 2008 11; 8(11):889-95. Schneider DS, Ayres JS. PMID: 18927577; PMCID: PMC4368196.
      View in: PubMed   Mentions: 359     Fields:    Translation:HumansAnimals
    47. Pathogenesis of listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin. PLoS Pathog. 2008 Jul 25; 4(7):e1000111. Gordon MD, Ayres JS, Schneider DS, Nusse R. PMID: 18654628; PMCID: PMC2453329.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    48. Identification of Drosophila mutants altering defense of and endurance to Listeria monocytogenes infection. Genetics. 2008 Mar; 178(3):1807-15. Ayres JS, Freitag N, Schneider DS. PMID: 18245331; PMCID: PMC2278058.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    49. Interactions between circadian rhythm and immunity in Drosophila melanogaster. Curr Biol. 2007 May 15; 17(10):R353-5. Shirasu-Hiza MM, Dionne MS, Pham LN, Ayres JS, Schneider DS. PMID: 17502084.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    50. Drosophila eiger mutants are sensitive to extracellular pathogens. PLoS Pathog. 2007 Mar; 3(3):e41. Schneider DS, Ayres JS, Brandt SM, Costa A, Dionne MS, Gordon MD, Mabery EM, Moule MG, Pham LN, Shirasu-Hiza MM. PMID: 17381241; PMCID: PMC1829408.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    51. Genomic dissection of microbial pathogenesis in cultured Drosophila cells. Trends Microbiol. 2006 Mar; 14(3):101-4. Ayres JS, Schneider DS. PMID: 16473012.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
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