Janelle Ayres

TitleAssociate Adjunct Professor
InstitutionUniversity of California San Diego
DepartmentCell and Developmental Biology
Address9500 Gilman Drive #0932
La Jolla CA 92093
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Tolerance defenses in host-microbiota interactions
    NIH/NIAID R01AI114929May 10, 2015 - Apr 30, 2020
    Role: Principal Investigator
    Control of intestinal microflora and inflammation by immune sensing of flagellin
    NIH/NIAID F32AI091068Jul 1, 2010 - Jun 30, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Wallace M, Green CR, Roberts LS, Lee YM, McCarville JL, Sanchez-Gurmaches J, Meurs N, Gengatharan JM, Hover JD, Phillips SA, Ciaraldi TP, Guertin DA, Cabrales P, Ayres JS, Nomura DK, Loomba R, Metallo CM. Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues. Nat Chem Biol. 2018 Nov; 14(11):1021-1031. PMID: 30327559.
      View in: PubMed
    2. Sanchez KK, Chen GY, Schieber AMP, Redford SE, Shokhirev MN, Leblanc M, Lee YM, Ayres JS. Cooperative Metabolic Adaptations in the Host Can Favor Asymptomatic Infection and Select for Attenuated Virulence in an Enteric Pathogen. Cell. 2018 Jul 31. PMID: 30100182.
      View in: PubMed
    3. Chen GY, Ayres JS. When the Gut Gets Tough, the Enterocytes Get Going. Immunity. 2018 May 15; 48(5):837-839. PMID: 29768167.
      View in: PubMed
    4. Lee YM, Ayres JS. Decoding the intestinal epithelium cell by cell. Nat Immunol. 2018 Jan; 19(1):7-9. PMID: 29242547.
      View in: PubMed
    5. Rao S, Ayres JS. Resistance and tolerance defenses in cancer: Lessons from infectious diseases. Semin Immunol. 2017 Aug; 32:54-61. PMID: 28865876.
      View in: PubMed
    6. Rauch I, Deets KA, Ji DX, von Moltke J, Tenthorey JL, Lee AY, Philip NH, Ayres JS, Brodsky IE, Gronert K, Vance RE. NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8. Immunity. 2017 04 18; 46(4):649-659. PMID: 28410991.
      View in: PubMed
    7. Rao S, Schieber AMP, O'Connor CP, Leblanc M, Michel D, Ayres JS. Pathogen-Mediated Inhibition of Anorexia Promotes Host Survival and Transmission. Cell. 2017 Jan 26; 168(3):503-516.e12. PMID: 28129542.
      View in: PubMed
    8. Ayres JS. Microbes Dress for Success: Tolerance or Resistance? Trends Microbiol. 2017 01; 25(1):1-3. PMID: 27894645.
      View in: PubMed
    9. Schieber AM, Ayres JS. Thermoregulation as a disease tolerance defense strategy. Pathog Dis. 2016 12; 74(9). PMID: 27815313.
      View in: PubMed
    10. Ayres JS. Disease Tolerance Trick or Treat: Give Your Brain Something Good to Eat. Cell. 2016 Sep 08; 166(6):1368-1370. PMID: 27610563.
      View in: PubMed
    11. Ayres JS. Cooperative Microbial Tolerance Behaviors in Host-Microbiota Mutualism. Cell. 2016 Jun 02; 165(6):1323-1331. PMID: 27259146; PMCID: PMC4903080 [Available on 06/02/17].
    12. Schieber AM, Lee YM, Chang MW, Leblanc M, Collins B, Downes M, Evans RM, Ayres JS. Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling. Science. 2015 Oct 30; 350(6260):558-63. PMID: 26516283; PMCID: PMC4732872 [Available on 10/30/16].
    13. Ayres JS. Inflammasome-microbiota interplay in host physiologies. Cell Host Microbe. 2013 Nov 13; 14(5):491-7. PMID: 24237695.
      View in: PubMed
    14. Manzanillo PS, Ayres JS, Watson RO, Collins AC, Souza G, Rae CS, Schneider DS, Nakamura K, Shiloh MU, Cox JS. The ubiquitin ligase parkin mediates resistance to intracellular pathogens. Nature. 2013 Sep 26; 501(7468):512-6. PMID: 24005326; PMCID: PMC3886920.
    15. von Moltke J, Ayres JS, Kofoed EM, Chavarría-Smith J, Vance RE. Recognition of bacteria by inflammasomes. Annu Rev Immunol. 2013; 31:73-106. PMID: 23215645.
      View in: PubMed
    16. Ayres JS, Trinidad NJ, Vance RE. Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota. Nat Med. 2012 May; 18(5):799-806. PMID: 22522562; PMCID: PMC3472005.
    17. Ayres JS, Vance RE. Cellular teamwork in antibacterial innate immunity. Nat Immunol. 2012 Jan 19; 13(2):115-7. PMID: 22261960.
      View in: PubMed
    18. Stone EF, Fulton BO, Ayres JS, Pham LN, Ziauddin J, Shirasu-Hiza MM. The circadian clock protein timeless regulates phagocytosis of bacteria in Drosophila. PLoS Pathog. 2012 Jan; 8(1):e1002445. PMID: 22253593; PMCID: PMC3257305.
    19. Ayres JS, Schneider DS. Tolerance of infections. Annu Rev Immunol. 2012; 30:271-94. PMID: 22224770.
      View in: PubMed
    20. Ayres JS, Schneider DS. The role of anorexia in resistance and tolerance to infections in Drosophila. PLoS Biol. 2009 Jul; 7(7):e1000150. PMID: 19597539; PMCID: PMC2701602.
    21. Ayres JS, Schneider DS. A signaling protease required for melanization in Drosophila affects resistance and tolerance of infections. PLoS Biol. 2008 Dec 09; 6(12):2764-73. PMID: 19071960.
      View in: PubMed
    22. Schneider DS, Ayres JS. Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases. Nat Rev Immunol. 2008 11; 8(11):889-95. PMID: 18927577; PMCID: PMC4368196.
    23. Gordon MD, Ayres JS, Schneider DS, Nusse R. Pathogenesis of listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin. PLoS Pathog. 2008 Jul 25; 4(7):e1000111. PMID: 18654628; PMCID: PMC2453329.
    24. Ayres JS, Freitag N, Schneider DS. Identification of Drosophila mutants altering defense of and endurance to Listeria monocytogenes infection. Genetics. 2008 Mar; 178(3):1807-15. PMID: 18245331; PMCID: PMC2278058.
    25. Shirasu-Hiza MM, Dionne MS, Pham LN, Ayres JS, Schneider DS. Interactions between circadian rhythm and immunity in Drosophila melanogaster. Curr Biol. 2007 May 15; 17(10):R353-5. PMID: 17502084.
      View in: PubMed
    26. Schneider DS, Ayres JS, Brandt SM, Costa A, Dionne MS, Gordon MD, Mabery EM, Moule MG, Pham LN, Shirasu-Hiza MM. Drosophila eiger mutants are sensitive to extracellular pathogens. PLoS Pathog. 2007 Mar; 3(3):e41. PMID: 17381241; PMCID: PMC1829408.
    27. Ayres JS, Schneider DS. Genomic dissection of microbial pathogenesis in cultured Drosophila cells. Trends Microbiol. 2006 Mar; 14(3):101-4. PMID: 16473012.
      View in: PubMed
    Janelle's Networks
    Derived automatically from this person's publications.
    People in Profiles who have published with this person.
    Related Authors
    People who share related concepts with this person.