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Arshad Desai

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentCellular and Molecular Medicine
Address9500 Gilman Drive #0653
La Jolla CA 92093
Phone858-534-9698
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    Our lab is interested in understanding how the replicated genome is accurately segregated during cell division.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Khaliullin RN, Green RA, Shi LZ, Gomez-Cavazos JS, Berns MW, Desai A, Oegema K. A positive feedback-based mechanism for constriction rate acceleration during cytokinesis in C. elegans. Elife. 2018 Jul 02; 7. PMID: 29963981.
      View in: PubMed
    2. Shimamoto Y, Kapoor TM. Analyzing the micromechanics of the cell division apparatus. Methods Cell Biol. 2018; 145:173-190. PMID: 29957203.
      View in: PubMed
    3. Hattersley N, Lara-Gonzalez P, Cheerambathur D, Gomez-Cavazos JS, Kim T, Prevo B, Khaliullin R, Lee KY, Ohta M, Green R, Oegema K, Desai A. Employing the one-cell C. elegans embryo to study cell division processes. Methods Cell Biol. 2018; 144:185-231. PMID: 29804670.
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    4. Nene RV, Putnam CD, Li BZ, Nguyen KG, Srivatsan A, Campbell CS, Desai A, Kolodner RD. Cdc73 suppresses genome instability by mediating telomere homeostasis. PLoS Genet. 2018 Jan; 14(1):e1007170. PMID: 29320491.
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    5. Kim T, Desai A. Meiosis: The Origins of Bias. Curr Biol. 2017 Dec 18; 27(24):R1309-R1311. PMID: 29257963.
      View in: PubMed
    6. Lara-Gonzalez P, Kim T, Desai A. Taming the Beast: Control of APC/CCdc20-Dependent Destruction. Cold Spring Harb Symp Quant Biol. 2017 Nov 13. PMID: 29133301.
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    7. Martino L, Morchoisne-Bolhy S, Cheerambathur DK, Van Hove L, Dumont J, Joly N, Desai A, Doye V, Pintard L. Channel Nucleoporins Recruit PLK-1 to Nuclear Pore Complexes to Direct Nuclear Envelope Breakdown in C. elegans. Dev Cell. 2017 10 23; 43(2):157-171.e7. PMID: 29065307.
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    8. Santaguida S, Richardson A, Iyer DR, M'Saad O, Zasadil L, Knouse KA, Wong YL, Rhind N, Desai A, Amon A. Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System. Dev Cell. 2017 06 19; 41(6):638-651.e5. PMID: 28633018.
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    9. Wang S, Tang NH, Lara-Gonzalez P, Zhao Z, Cheerambathur DK, Prevo B, Chisholm AD, Desai A, Oegema K. A toolkit for GFP-mediated tissue-specific protein degradation in C. elegans. Development. 2017 07 15; 144(14):2694-2701. PMID: 28619826.
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    10. Kim T, Lara-Gonzalez P, Prevo B, Meitinger F, Cheerambathur DK, Oegema K, Desai A. Kinetochores accelerate or delay APC/C activation by directing Cdc20 to opposing fates. Genes Dev. 2017 06 01; 31(11):1089-1094. PMID: 28698300.
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    11. Cheerambathur DK, Prevo B, Hattersley N, Lewellyn L, Corbett KD, Oegema K, Desai A. Dephosphorylation of the Ndc80 Tail Stabilizes Kinetochore-Microtubule Attachments via the Ska Complex. Dev Cell. 2017 05 22; 41(4):424-437.e4. PMID: 28535376.
      View in: PubMed
    12. Fink S, Turnbull K, Desai A, Campbell CS. An engineered minimal chromosomal passenger complex reveals a role for INCENP/Sli15 spindle association in chromosome biorientation. J Cell Biol. 2017 04 03; 216(4):911-923. PMID: 28314741.
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    13. Coller HA, Desai A. Cell cycle, cell division, and cell death. Mol Biol Cell. 2017 Mar 15; 28(6):693-694. PMID: 28292908.
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    14. Ohta M, Desai A, Oegema K. How centrioles acquire the ability to reproduce. Elife. 2017 Mar 08; 6. PMID: 28271993.
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    15. Musacchio A, Desai A. A Molecular View of Kinetochore Assembly and Function. Biology (Basel). 2017 Jan 24; 6(1). PMID: 28125021.
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    16. Hattersley N, Desai A. The nucleoporin MEL-28/ELYS: A PP1 scaffold during M-phase exit. Cell Cycle. 2017 Mar 19; 16(6):489-490. PMID: 28102742.
      View in: PubMed
    17. Hattersley N, Cheerambathur D, Moyle M, Stefanutti M, Richardson A, Lee KY, Dumont J, Oegema K, Desai A. A Nucleoporin Docks Protein Phosphatase 1 to Direct Meiotic Chromosome Segregation and Nuclear Assembly. Dev Cell. 2016 09 12; 38(5):463-77. PMID: 27623381.
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    18. Meitinger F, Anzola JV, Kaulich M, Richardson A, Stender JD, Benner C, Glass CK, Dowdy SF, Desai A, Shiau AK, Oegema K. 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration. J Cell Biol. 2016 07 18; 214(2):155-66. PMID: 27432897.
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    19. Cheerambathur DK, Prevo B, Desai A. A TOGgle for Tension at Kinetochores. Cell. 2016 Jun 02; 165(6):1316-1318. PMID: 27259144.
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    20. Gerson-Gurwitz A, Wang S, Sathe S, Green R, Yeo GW, Oegema K, Desai A. A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions. Cell. 2016 Apr 07; 165(2):396-409. PMID: 27020753; PMCID: PMC4826293 [Available on 04/07/17].
    21. Kim T, Moyle MW, Lara-Gonzalez P, De Groot C, Oegema K, Desai A. Correction: Kinetochore-localized BUB-1/BUB-3 complex promotes anaphase onset in C. elegans. J Cell Biol. 2016 Mar 14; 212(6):737. PMID: 26953348; PMCID: PMC4792070.
    22. de Groot CO, Hsia JE, Anzola JV, Motamedi A, Yoon M, Wong YL, Jenkins D, Lee HJ, Martinez MB, Davis RL, Gahman TC, Desai A, Shiau AK. A Cell Biologist's Field Guide to Aurora Kinase Inhibitors. Front Oncol. 2015; 5:285. PMID: 26732741; PMCID: PMC4685510.
    23. Wang S, Wu D, Quintin S, Green RA, Cheerambathur DK, Ochoa SD, Desai A, Oegema K. NOCA-1 functions with ?-tubulin and in parallel to Patronin to assemble non-centrosomal microtubule arrays in C. elegans. Elife. 2015 Sep 15; 4:e08649. PMID: 26371552; PMCID: PMC4608005.
    24. Espeut J, Lara-Gonzalez P, Sassine M, Shiau AK, Desai A, Abrieu A. Natural Loss of Mps1 Kinase in Nematodes Uncovers a Role for Polo-like Kinase 1 in Spindle Checkpoint Initiation. Cell Rep. 2015 Jul 07; 12(1):58-65. PMID: 26119738; PMCID: PMC4668945.
    25. Shen Y, Li J, Nitta M, Futalan D, Steed T, Treiber JM, Taich Z, Stevens D, Wykosky J, Chen HZ, Carter BS, Becher OJ, Kennedy R, Esashi F, Sarkaria JN, Furnari FB, Cavenee WK, Desai A, Chen CC. Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition. Oncotarget. 2015 May 20; 6(14):11751-67. PMID: 26059434.
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    26. Kim T, Moyle MW, Lara-Gonzalez P, De Groot C, Oegema K, Desai A. Kinetochore-localized BUB-1/BUB-3 complex promotes anaphase onset in C. elegans. J Cell Biol. 2015 May 25; 209(4):507-17. PMID: 25987605; PMCID: PMC4442812.
    27. Wong YL, Anzola JV, Davis RL, Yoon M, Motamedi A, Kroll A, Seo CP, Hsia JE, Kim SK, Mitchell JW, Mitchell BJ, Desai A, Gahman TC, Shiau AK, Oegema K. Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science. 2015 Jun 05; 348(6239):1155-60. PMID: 25931445; PMCID: PMC4764081.
    28. Monen J, Hattersley N, Muroyama A, Stevens D, Oegema K, Desai A. Separase Cleaves the N-Tail of the CENP-A Related Protein CPAR-1 at the Meiosis I Metaphase-Anaphase Transition in C. elegans. PLoS One. 2015; 10(4):e0125382. PMID: 25919583; PMCID: PMC4412405.
    29. Holland AJ, Reis RM, Niessen S, Pereira C, Andres DA, Spielmann HP, Cleveland DW, Desai A, Gassmann R. Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors. Mol Biol Cell. 2015 May 15; 26(10):1845-56. PMID: 25808490; PMCID: PMC4436830.
    30. Folco HD, Campbell CS, May KM, Espinoza CA, Oegema K, Hardwick KG, Grewal SIS, Desai A. The CENP-A N-tail confers epigenetic stability to centromeres via the CENP-T branch of the CCAN in fission yeast. Curr Biol. 2015 Feb 02; 25(3):348-356. PMID: 25619765.
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    31. Kern DM, Kim T, Rigney M, Hattersley N, Desai A, Cheeseman IM. The outer kinetochore protein KNL-1 contains a defined oligomerization domain in nematodes. Mol Biol Cell. 2015 Jan 15; 26(2):229-37. PMID: 25411336; PMCID: PMC4294671.
    32. Corbett KD, Desai A. A new piece in the kinetochore jigsaw puzzle. J Cell Biol. 2014 Aug 18; 206(4):457-9. PMID: 25135931; PMCID: PMC4137055.
    33. Goellner EM, Smith CE, Campbell CS, Hombauer H, Desai A, Putnam CD, Kolodner RD. PCNA and Msh2-Msh6 activate an Mlh1-Pms1 endonuclease pathway required for Exo1-independent mismatch repair. Mol Cell. 2014 Jul 17; 55(2):291-304. PMID: 24981171; PMCID: PMC4113420.
    34. Campbell CS, Hombauer H, Srivatsan A, Bowen N, Gries K, Desai A, Putnam CD, Kolodner RD. Mlh2 is an accessory factor for DNA mismatch repair in Saccharomyces cerevisiae. PLoS Genet. 2014 May; 10(5):e1004327. PMID: 24811092; PMCID: PMC4014439.
    35. Moyle MW, Kim T, Hattersley N, Espeut J, Cheerambathur DK, Oegema K, Desai A. A Bub1-Mad1 interaction targets the Mad1-Mad2 complex to unattached kinetochores to initiate the spindle checkpoint. J Cell Biol. 2014 Mar 03; 204(5):647-57. PMID: 24567362; PMCID: PMC3941058.
    36. Bahmanyar S, Biggs R, Schuh AL, Desai A, Müller-Reichert T, Audhya A, Dixon JE, Oegema K. Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown. Genes Dev. 2014 Jan 15; 28(2):121-6. PMID: 24449268; PMCID: PMC3909786.
    37. Cheerambathur DK, Desai A. Linked in: formation and regulation of microtubule attachments during chromosome segregation. Curr Opin Cell Biol. 2014 Feb; 26:113-22. PMID: 24529253; PMCID: PMC3940152.
    38. Stevens D, Oegema K, Desai A. Meiotic double-strand breaks uncover and protect against mitotic errors in the C. elegans germline. Curr Biol. 2013 Dec 02; 23(23):2400-6. PMID: 24239117; PMCID: PMC3885542.
    39. Cheerambathur DK, Gassmann R, Cook B, Oegema K, Desai A. Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation. Science. 2013 Dec 06; 342(6163):1239-42. PMID: 24231804; PMCID: PMC3885540.
    40. Green RA, Mayers JR, Wang S, Lewellyn L, Desai A, Audhya A, Oegema K. The midbody ring scaffolds the abscission machinery in the absence of midbody microtubules. J Cell Biol. 2013 Nov 11; 203(3):505-20. PMID: 24217623; PMCID: PMC3824018.
    41. Smith CE, Mendillo ML, Bowen N, Hombauer H, Campbell CS, Desai A, Putnam CD, Kolodner RD. Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway. PLoS Genet. 2013 Oct; 9(10):e1003869. PMID: 24204293; PMCID: PMC3814310.
    42. Zanin E, Desai A, Poser I, Toyoda Y, Andree C, Moebius C, Bickle M, Conradt B, Piekny A, Oegema K. A conserved RhoGAP limits M phase contractility and coordinates with microtubule asters to confine RhoA during cytokinesis. Dev Cell. 2013 Sep 16; 26(5):496-510. PMID: 24012485; PMCID: PMC4239416.
    43. Varma D, Wan X, Cheerambathur D, Gassmann R, Suzuki A, Lawrimore J, Desai A, Salmon ED. Spindle assembly checkpoint proteins are positioned close to core microtubule attachment sites at kinetochores. J Cell Biol. 2013 Sep 02; 202(5):735-46. PMID: 23979716; PMCID: PMC3760617.
    44. Fachinetti D, Folco HD, Nechemia-Arbely Y, Valente LP, Nguyen K, Wong AJ, Zhu Q, Holland AJ, Desai A, Jansen LE, Cleveland DW. A two-step mechanism for epigenetic specification of centromere identity and function. Nat Cell Biol. 2013 Sep; 15(9):1056-66. PMID: 23873148; PMCID: PMC4418506.
    45. Lettman MM, Wong YL, Viscardi V, Niessen S, Chen SH, Shiau AK, Zhou H, Desai A, Oegema K. Direct binding of SAS-6 to ZYG-1 recruits SAS-6 to the mother centriole for cartwheel assembly. Dev Cell. 2013 May 13; 25(3):284-98. PMID: 23673331; PMCID: PMC3655416.
    46. Campbell CS, Desai A. Tension sensing by Aurora B kinase is independent of survivin-based centromere localization. Nature. 2013 May 02; 497(7447):118-21. PMID: 23604256; PMCID: PMC3644022.
    47. Campbell CS, Desai A. What the hec is up with mouse oocyte meiosis? Dev Cell. 2013 Apr 15; 25(1):3-4. PMID: 23597481; PMCID: PMC3804012.
    48. Olson SK, Greenan G, Desai A, Müller-Reichert T, Oegema K. Hierarchical assembly of the eggshell and permeability barrier in C. elegans. J Cell Biol. 2012 Aug 20; 198(4):731-48. PMID: 22908315; PMCID: PMC3514041.
    49. Gassmann R, Rechtsteiner A, Yuen KW, Muroyama A, Egelhofer T, Gaydos L, Barron F, Maddox P, Essex A, Monen J, Ercan S, Lieb JD, Oegema K, Strome S, Desai A. An inverse relationship to germline transcription defines centromeric chromatin in C. elegans. Nature. 2012 Apr 08; 484(7395):534-7. PMID: 22495302; PMCID: PMC3538161.
    50. Dumont J, Desai A. Acentrosomal spindle assembly and chromosome segregation during oocyte meiosis. Trends Cell Biol. 2012 May; 22(5):241-9. PMID: 22480579; PMCID: PMC3348331.
    51. Espeut J, Cheerambathur DK, Krenning L, Oegema K, Desai A. Microtubule binding by KNL-1 contributes to spindle checkpoint silencing at the kinetochore. J Cell Biol. 2012 Feb 20; 196(4):469-82. PMID: 22331849; PMCID: PMC3284002.
    52. Maddox PS, Corbett KD, Desai A. Structure, assembly and reading of centromeric chromatin. Curr Opin Genet Dev. 2012 Apr; 22(2):139-47. PMID: 22178421; PMCID: PMC3319190.
    53. Hombauer H, Campbell CS, Smith CE, Desai A, Kolodner RD. Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates. Cell. 2011 Nov 23; 147(5):1040-53. PMID: 22118461; PMCID: PMC3478091.
    54. Yuen KW, Nabeshima K, Oegema K, Desai A. Rapid de novo centromere formation occurs independently of heterochromatin protein 1 in C. elegans embryos. Curr Biol. 2011 Nov 08; 21(21):1800-7. PMID: 22018540; PMCID: PMC3249440.
    55. Carvalho A, Olson SK, Gutierrez E, Zhang K, Noble LB, Zanin E, Desai A, Groisman A, Oegema K. Acute drug treatment in the early C. elegans embryo. PLoS One. 2011; 6(9):e24656. PMID: 21935434.
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    56. Stevens D, Gassmann R, Oegema K, Desai A. Uncoordinated loss of chromatid cohesion is a common outcome of extended metaphase arrest. PLoS One. 2011; 6(8):e22969. PMID: 21829677; PMCID: PMC3149067.
    57. Green RA, Kao HL, Audhya A, Arur S, Mayers JR, Fridolfsson HN, Schulman M, Schloissnig S, Niessen S, Laband K, Wang S, Starr DA, Hyman AA, Schedl T, Desai A, Piano F, Gunsalus KC, Oegema K. A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue. Cell. 2011 Apr 29; 145(3):470-82. PMID: 21529718; PMCID: PMC3086541.
    58. Lewellyn L, Carvalho A, Desai A, Maddox AS, Oegema K. The chromosomal passenger complex and centralspindlin independently contribute to contractile ring assembly. J Cell Biol. 2011 Apr 04; 193(1):155-69. PMID: 21464231; PMCID: PMC3082186.
    59. Zanin E, Dumont J, Gassmann R, Cheeseman I, Maddox P, Bahmanyar S, Carvalho A, Niessen S, Yates JR, Oegema K, Desai A. Affinity purification of protein complexes in C. elegans. Methods Cell Biol. 2011; 106:289-322. PMID: 22118282; PMCID: PMC3319706.
    60. Liu T, Rechtsteiner A, Egelhofer TA, Vielle A, Latorre I, Cheung MS, Ercan S, Ikegami K, Jensen M, Kolasinska-Zwierz P, Rosenbaum H, Shin H, Taing S, Takasaki T, Iniguez AL, Desai A, Dernburg AF, Kimura H, Lieb JD, Ahringer J, Strome S, Liu XS. Broad chromosomal domains of histone modification patterns in C. elegans. Genome Res. 2011 Feb; 21(2):227-36. PMID: 21177964.
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    61. Gerstein MB, Lu ZJ, Van Nostrand EL, Cheng C, Arshinoff BI, Liu T, Yip KY, Robilotto R, Rechtsteiner A, Ikegami K, Alves P, Chateigner A, Perry M, Morris M, Auerbach RK, Feng X, Leng J, Vielle A, Niu W, Rhrissorrakrai K, Agarwal A, Alexander RP, Barber G, Brdlik CM, Brennan J, Brouillet JJ, Carr A, Cheung MS, Clawson H, Contrino S, Dannenberg LO, Dernburg AF, Desai A, Dick L, Dosé AC, Du J, Egelhofer T, Ercan S, Euskirchen G, Ewing B, Feingold EA, Gassmann R, Good PJ, Green P, Gullier F, Gutwein M, Guyer MS, Habegger L, Han T, Henikoff JG, Henz SR, Hinrichs A, Holster H, Hyman T, Iniguez AL, Janette J, Jensen M, Kato M, Kent WJ, Kephart E, Khivansara V, Khurana E, Kim JK, Kolasinska-Zwierz P, Lai EC, Latorre I, Leahey A, Lewis S, Lloyd P, Lochovsky L, Lowdon RF, Lubling Y, Lyne R, MacCoss M, Mackowiak SD, Mangone M, McKay S, Mecenas D, Merrihew G, Miller DM, Muroyama A, Murray JI, Ooi SL, Pham H, Phippen T, Preston EA, Rajewsky N, Rätsch G, Rosenbaum H, Rozowsky J, Rutherford K, Ruzanov P, Sarov M, Sasidharan R, Sboner A, Scheid P, Segal E, Shin H, Shou C, Slack FJ, Slightam C, Smith R, Spencer WC, Stinson EO, Taing S, Takasaki T, Vafeados D, Voronina K, Wang G, Washington NL, Whittle CM, Wu B, Yan KK, Zeller G, Zha Z, Zhong M, Zhou X. Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science. 2010 Dec 24; 330(6012):1775-87. PMID: 21177976.
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    62. Folco HD, Desai A. A PSHaver for centromeric histones. Mol Cell. 2010 Nov 12; 40(3):351-2. PMID: 21070962; PMCID: PMC3003300.
    63. Dumont J, Oegema K, Desai A. A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis. Nat Cell Biol. 2010 Sep; 12(9):894-901. PMID: 20729837; PMCID: PMC3052858.
    64. Liu W, Tanasa B, Tyurina OV, Zhou TY, Gassmann R, Liu WT, Ohgi KA, Benner C, Garcia-Bassets I, Aggarwal AK, Desai A, Dorrestein PC, Glass CK, Rosenfeld MG. PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature. 2010 Jul 22; 466(7305):508-12. PMID: 20622854; PMCID: PMC3059551.
    65. Gassmann R, Holland AJ, Varma D, Wan X, Civril F, Cleveland DW, Oegema K, Salmon ED, Desai A. Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells. Genes Dev. 2010 May; 24(9):957-71. PMID: 20439434; PMCID: PMC2861194.
    66. Desai A, Dogterom M. Cell structure and dynamics. Curr Opin Cell Biol. 2010 Feb; 22(1):1-3. PMID: 20102790.
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    67. Lewellyn L, Dumont J, Desai A, Oegema K. Analyzing the effects of delaying aster separation on furrow formation during cytokinesis in the Caenorhabditis elegans embryo. Mol Biol Cell. 2010 Jan 01; 21(1):50-62. PMID: 19889842; PMCID: PMC2801719.
    68. Dammermann A, Pemble H, Mitchell BJ, McLeod I, Yates JR, Kintner C, Desai A, Oegema K. The hydrolethalus syndrome protein HYLS-1 links core centriole structure to cilia formation. Genes Dev. 2009 Sep 01; 23(17):2046-59. PMID: 19656802; PMCID: PMC2751977.
    69. Carvalho A, Desai A, Oegema K. Structural memory in the contractile ring makes the duration of cytokinesis independent of cell size. Cell. 2009 May 29; 137(5):926-37. PMID: 19490897.
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    70. Wan X, O'Quinn RP, Pierce HL, Joglekar AP, Gall WE, DeLuca JG, Carroll CW, Liu ST, Yen TJ, McEwen BF, Stukenberg PT, Desai A, Salmon ED. Protein architecture of the human kinetochore microtubule attachment site. Cell. 2009 May 15; 137(4):672-84. PMID: 19450515; PMCID: PMC2699050.
    71. Essex A, Dammermann A, Lewellyn L, Oegema K, Desai A. Systematic analysis in Caenorhabditis elegans reveals that the spindle checkpoint is composed of two largely independent branches. Mol Biol Cell. 2009 Feb; 20(4):1252-67. PMID: 19109417; PMCID: PMC2642744.
    72. Canman JC, Lewellyn L, Laband K, Smerdon SJ, Desai A, Bowerman B, Oegema K. Inhibition of Rac by the GAP activity of centralspindlin is essential for cytokinesis. Science. 2008 Dec 05; 322(5907):1543-6. PMID: 19056985; PMCID: PMC2736296.
    73. McIntosh JR, Grishchuk EL, Morphew MK, Efremov AK, Zhudenkov K, Volkov VA, Cheeseman IM, Desai A, Mastronarde DN, Ataullakhanov FI. Fibrils connect microtubule tips with kinetochores: a mechanism to couple tubulin dynamics to chromosome motion. Cell. 2008 Oct 17; 135(2):322-33. PMID: 18957206; PMCID: PMC2746696.
    74. Wilson-Kubalek EM, Cheeseman IM, Yoshioka C, Desai A, Milligan RA. Orientation and structure of the Ndc80 complex on the microtubule lattice. J Cell Biol. 2008 Sep 22; 182(6):1055-61. PMID: 18794333; PMCID: PMC2542468.
    75. Liu J, Desai A, Onuchic JN, Hwa T. An integrated mechanobiochemical feedback mechanism describes chromosome motility from prometaphase to anaphase in mitosis. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):13752-7. PMID: 18780795; PMCID: PMC2544526.
    76. Gassmann R, Essex A, Hu JS, Maddox PS, Motegi F, Sugimoto A, O'Rourke SM, Bowerman B, McLeod I, Yates JR, Oegema K, Cheeseman IM, Desai A. A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex. Genes Dev. 2008 Sep 01; 22(17):2385-99. PMID: 18765790; PMCID: PMC2532926.
    77. Audhya A, Desai A. Proteomics in Caenorhabditis elegans. Brief Funct Genomic Proteomic. 2008 May; 7(3):205-10. PMID: 18372286.
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    78. Dammermann A, Maddox PS, Desai A, Oegema K. SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules. J Cell Biol. 2008 Feb 25; 180(4):771-85. PMID: 18299348; PMCID: PMC2265562.
    79. Yuen KW, Desai A. The wages of CIN. J Cell Biol. 2008 Feb 25; 180(4):661-3. PMID: 18283117; PMCID: PMC2265563.
    80. Tanaka TU, Desai A. Kinetochore-microtubule interactions: the means to the end. Curr Opin Cell Biol. 2008 Feb; 20(1):53-63. PMID: 18182282; PMCID: PMC2358929.
    81. Green RA, Audhya A, Pozniakovsky A, Dammermann A, Pemble H, Monen J, Portier N, Hyman A, Desai A, Oegema K. Expression and imaging of fluorescent proteins in the C. elegans gonad and early embryo. Methods Cell Biol. 2008; 85:179-218. PMID: 18155464.
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    82. Cheeseman IM, Desai A. Molecular architecture of the kinetochore-microtubule interface. Nat Rev Mol Cell Biol. 2008 Jan; 9(1):33-46. PMID: 18097444.
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    83. Cheeseman IM, Hori T, Fukagawa T, Desai A. KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates. Mol Biol Cell. 2008 Feb; 19(2):587-94. PMID: 18045986; PMCID: PMC2230600.
    84. Liu J, Desai A, Onuchic JN, Hwa T. A mechanobiochemical mechanism for monooriented chromosome oscillation in mitosis. Proc Natl Acad Sci U S A. 2007 Oct 09; 104(41):16104-9. PMID: 17911248; PMCID: PMC2042169.
    85. Sandall S, Desai A. When it comes to couple(r)s, do opposites attract? Nat Struct Mol Biol. 2007 Sep; 14(9):790-2. PMID: 17823608.
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    86. Audhya A, Desai A, Oegema K. A role for Rab5 in structuring the endoplasmic reticulum. J Cell Biol. 2007 Jul 02; 178(1):43-56. PMID: 17591921; PMCID: PMC2064419.
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    91. Black BE, Jansen LE, Maddox PS, Foltz DR, Desai A, Shah JV, Cleveland DW. Centromere identity maintained by nucleosomes assembled with histone H3 containing the CENP-A targeting domain. Mol Cell. 2007 Jan 26; 25(2):309-22. PMID: 17244537.
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    92. Sandall S, Severin F, McLeod IX, Yates JR, Oegema K, Hyman A, Desai A. A Bir1-Sli15 complex connects centromeres to microtubules and is required to sense kinetochore tension. Cell. 2006 Dec 15; 127(6):1179-91. PMID: 17174893; PMCID: PMC2265205.
    93. Cheeseman IM, Chappie JS, Wilson-Kubalek EM, Desai A. The conserved KMN network constitutes the core microtubule-binding site of the kinetochore. Cell. 2006 Dec 01; 127(5):983-97. PMID: 17129783.
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    94. Smolka MB, Chen SH, Maddox PS, Enserink JM, Albuquerque CP, Wei XX, Desai A, Kolodner RD, Zhou H. An FHA domain-mediated protein interaction network of Rad53 reveals its role in polarized cell growth. J Cell Biol. 2006 Dec 04; 175(5):743-53. PMID: 17130285; PMCID: PMC2064674.
    95. Maddox PS, Portier N, Desai A, Oegema K. Molecular analysis of mitotic chromosome condensation using a quantitative time-resolved fluorescence microscopy assay. Proc Natl Acad Sci U S A. 2006 Oct 10; 103(41):15097-102. PMID: 17005720; PMCID: PMC1622782.
    96. Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. Nat Cell Biol. 2006 May; 8(5):446-57. PMID: 16622420.
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    97. Kline SL, Cheeseman IM, Hori T, Fukagawa T, Desai A. The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. J Cell Biol. 2006 Apr 10; 173(1):9-17. PMID: 16585270; PMCID: PMC2063780.
    98. Budde PP, Desai A, Heald R. Analysis of microtubule polymerization in vitro and during the cell cycle in Xenopus egg extracts. Methods. 2006 Jan; 38(1):29-34. PMID: 16343934.
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    99. Monen J, Maddox PS, Hyndman F, Oegema K, Desai A. Differential role of CENP-A in the segregation of holocentric C. elegans chromosomes during meiosis and mitosis. Nat Cell Biol. 2005 Dec; 7(12):1248-55. PMID: 16273096.
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    100. Bomont P, Maddox P, Shah JV, Desai A, Cleveland DW. Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F. EMBO J. 2005 Nov 16; 24(22):3927-39. PMID: 16252009; PMCID: PMC1283947.
    101. Audhya A, Hyndman F, McLeod IX, Maddox AS, Yates JR, Desai A, Oegema K. A complex containing the Sm protein CAR-1 and the RNA helicase CGH-1 is required for embryonic cytokinesis in Caenorhabditis elegans. J Cell Biol. 2005 Oct 24; 171(2):267-79. PMID: 16247027; PMCID: PMC2171198.
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    103. Ozlü N, Srayko M, Kinoshita K, Habermann B, O'toole ET, Müller-Reichert T, Schmalz N, Desai A, Hyman AA. An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles. Dev Cell. 2005 Aug; 9(2):237-48. PMID: 16054030.
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    104. Maddox AS, Habermann B, Desai A, Oegema K. Distinct roles for two C. elegans anillins in the gonad and early embryo. Development. 2005 Jun; 132(12):2837-48. PMID: 15930113.
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    105. Cheeseman IM, MacLeod I, Yates JR, Oegema K, Desai A. The CENP-F-like proteins HCP-1 and HCP-2 target CLASP to kinetochores to mediate chromosome segregation. Curr Biol. 2005 Apr 26; 15(8):771-7. PMID: 15854912.
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    106. Wittmann T, Desai A. Microtubule cytoskeleton: a new twist at the end. Curr Biol. 2005 Feb 22; 15(4):R126-9. PMID: 15723782.
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    107. Kline-Smith SL, Sandall S, Desai A. Kinetochore-spindle microtubule interactions during mitosis. Curr Opin Cell Biol. 2005 Feb; 17(1):35-46. PMID: 15661517.
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    108. Cheeseman IM, Desai A. A combined approach for the localization and tandem affinity purification of protein complexes from metazoans. Sci STKE. 2005 Jan 11; 2005(266):pl1. PMID: 15644491.
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    109. Dammermann A, Müller-Reichert T, Pelletier L, Habermann B, Desai A, Oegema K. Centriole assembly requires both centriolar and pericentriolar material proteins. Dev Cell. 2004 Dec; 7(6):815-29. PMID: 15572125.
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    110. Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A. A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Genes Dev. 2004 Sep 15; 18(18):2255-68. PMID: 15371340; PMCID: PMC517519.
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    112. Cheeseman IM, Desai A. Cell division: AAAtacking the mitotic spindle. Curr Biol. 2004 Jan 20; 14(2):R70-2. PMID: 14738753.
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    113. Maddox PS, Oegema K, Desai A, Cheeseman IM. "Holo"er than thou: chromosome segregation and kinetochore function in C. elegans. Chromosome Res. 2004; 12(6):641-53. PMID: 15289669.
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    114. Desai A, Rybina S, Müller-Reichert T, Shevchenko A, Shevchenko A, Hyman A, Oegema K. KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans. Genes Dev. 2003 Oct 01; 17(19):2421-35. PMID: 14522947; PMCID: PMC218079.
    115. Dammermann A, Desai A, Oegema K. The minus end in sight. Curr Biol. 2003 Aug 05; 13(15):R614-24. PMID: 12906817.
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    116. Walczak CE, Gan EC, Desai A, Mitchison TJ, Kline-Smith SL. The microtubule-destabilizing kinesin XKCM1 is required for chromosome positioning during spindle assembly. Curr Biol. 2002 Oct 29; 12(21):1885-9. PMID: 12419191.
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    117. Maddox P, Desai A, Oegema K, Mitchison TJ, Salmon ED. Poleward microtubule flux is a major component of spindle dynamics and anaphase a in mitotic Drosophila embryos. Curr Biol. 2002 Oct 01; 12(19):1670-4. PMID: 12361570.
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