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Dr. Chambers is a professor of pediatrics at University of California, San Diego and Director of Clinical Research for the Department of Pediatrics at UCSD and Rady Children's Hospital. She is a perinatal epidemiologist, whose research is focused on environmental exposures and pregnancy and child health outcomes, including birth defects. She co-directs the Center for the Promotion of Maternal Health and Infant Development in the Department of Pediatrics at UCSD and is the Program Director of MotherToBabyCalifornia - a telephone-based service providing individualized risk assessments for pregnant women and their providers in the State of California. She is a founding principal investigator for the Vaccines and Medications in Pregnancy Surveillance System (VAMPSS) which is the first national system to evaluate medication and vaccine safety in human pregnancy, currently funded by the US DHHS, CDC, FDA and the National Vaccine Program Office. She headed the National Children's Study San Diego site, and has conducted extensive research on improved diagnosis, prevention and treatment for Fetal Alcohol Spectrum Disorders.

Dr. Chambers’ currently funded research activities include a set of North American cohort studies evaluating the impact of autoimmune diseases and the medications used to treat them on pregnancy outcomes, a California Native American Research Center project testing the effectiveness of a web-based vs. a peer health educator model for preventing risky alcohol consumption in women of childbearing age, a comparative effectiveness study of asthma medications in pregnancy, a North American-wide fetal safety study of influenza vaccine and antiviral drugs used in pregnancy, and a study to establish the prevalence of Fetal Alcohol Spectrum Disorders for the first time in the U.S. Her international clinical research projects are focused on addressing medication and vaccine safety in pregnancy as well as Fetal Alcohol Spectrum Disorders, and involve studies focused on prevention and intervention in Ukraine, Russia, South Africa, with collaborations in Australia and Poland.