Jerrold Olefsky

Title(s)Recall Hcomp, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Effects of Fractalkine on Beta Cell Function
    NIH R01DK101395Sep 19, 2014 - Aug 31, 2018
    Role: Principal Investigator
    Energetics & Breast Cancer: Obesity, Inflammation, Insulin Resistance & Risk
    NIH U54CA155435Jul 7, 2011 - May 31, 2017
    Role: Co-Investigator
    Molecular Mechanisms of Inflammation, Steatosis and Hepatic Insulin Resistance
    NIH R24DK090962Sep 30, 2010 - Aug 31, 2012
    Role: Principal Investigator
    Gene Networks controlling macrophage-adipocyte interactions in insulin
    NIH/NIDDK P01DK074868Apr 1, 2006 - Apr 30, 2017
    Role: Co-Investigator
    Estrogen Effects in Insulin Target and Granulosa Cells
    NIH R55DK068606Sep 30, 2004 - Aug 31, 2006
    Role: Principal Investigator
    Diabetes Research Center (DRC)
    NIH P30DK063491Dec 1, 2002 - Jun 30, 2025
    Role: Principal Investigator
    Estrogens and Insulin Resistance in Women
    NIH R01DK061964Jul 1, 2002 - May 31, 2007
    Role: Principal Investigator
    PKA & PKC Targeting Mechanisms (Program Project)
    NIH P01DK054441Dec 15, 1998 - Mar 31, 2019
    Role: Co-Investigator
    12/22 Limited Competition for the Continuation of the Diabetes Prevention Program Outcomes Study (DPPOS) - Clinical Center
    NIH U01DK048339Sep 10, 1994 - Jan 31, 2022
    Role: Principal Investigator
    Training Program in Diabetes Research
    NIH T32DK007494Jul 1, 1984 - Aug 31, 2022
    Role: Principal Investigator
    TRAINING PROGRAM IN DIABETES RESEARCH
    NIH T32AM007494Jul 1, 1984 - Jun 30, 1989
    Role: Principal Investigator
    Insulin Receptors and the Glucose Transport System
    NIH R01DK033651Aug 1, 1983 - Jun 30, 2014
    Role: Principal Investigator
    INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEM
    NIH R37DK033651Aug 1, 1983 - Jun 30, 2010
    Role: Principal Investigator
    MECHANISMS OF INSULIN RESISTANCE IN MAN
    NIH R01DK033649Aug 1, 1983 - Mar 31, 2002
    Role: Principal Investigator
    MECHANISMS OF INSULIN RESISTANCE IN MAN
    NIH R37DK033649Aug 1, 1983 - Mar 31, 1998
    Role: Principal Investigator
    INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEM
    NIH R01AM033651Aug 1, 1983 - Mar 31, 1990
    Role: Principal Investigator
    MECHANISMS OF INSULIN RESISTANCE IN MAN
    NIH R01AM033649Aug 1, 1983 - May 31, 1989
    Role: Principal Investigator
    Center for Reproductive Science and Medicine
    NIH U54HD012303Dec 1, 1978 - Jul 31, 2016
    Role: Co-Investigator
    General Clinical Research Center
    NIH M01RR000827Mar 1, 1974 - Nov 30, 2010
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis. Cell Metab. 2024 Oct 01; 36(10):2341-2354.e6. Zhang P, Liu J, Lee A, Tsaur I, Ohira M, Duong V, Vo N, Watari K, Su H, Kim JY, Gu L, Zhu M, Shalapour S, Hosseini M, Bandyopadhyay G, Zeng S, Llorente C, Zhao HN, Lamichhane S, Mohan S, Dorrestein PC, Olefsky JM, Schnabl B, Soroosh P, Karin M. PMID: 39317186.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Lipid-associated macrophages' promotion of fibrosis resolution during MASH regression requires TREM2. Proc Natl Acad Sci U S A. 2024 Aug 27; 121(35):e2405746121. Ganguly S, Rosenthal SB, Ishizuka K, Troutman TD, Rohm TV, Khader N, Aleman-Muench G, Sano Y, Archilei S, Soroosh P, Olefsky JM, Feldstein AE, Kisseleva T, Loomba R, Glass CK, Brenner DA, Dhar D. PMID: 39172787; PMCID: PMC11363294.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    3. Author Correction: Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization. Nat Metab. 2024 Aug; 6(8):1646. Rohm TV, Castellani Gomes Dos Reis F, Isaac R, Murphy C, Cunha E Rocha K, Bandyopadhyay G, Gao H, Libster AM, Zapata RC, Lee YS, Ying W, Miciano C, Wang A, Olefsky JM. PMID: 38969830.
      View in: PubMed   Mentions: 1     Fields:    
    4. TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis. Cell Metab. 2024 May 07; 36(5):1030-1043.e7. Isaac R, Bandyopadhyay G, Rohm TV, Kang S, Wang J, Pokhrel N, Sakane S, Zapata R, Libster AM, Vinik Y, Berhan A, Kisseleva T, Borok Z, Zick Y, Telese F, Webster NJG, Olefsky JM. PMID: 38670107; PMCID: PMC11113091.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization. Nat Metab. 2024 May; 6(5):880-898. Rohm TV, Castellani Gomes Dos Reis F, Isaac R, Murphy C, Cunha E Rocha K, Bandyopadhyay G, Gao H, Libster AM, Zapata RC, Lee YS, Ying W, Miciano C, Wang A, Olefsky JM. PMID: 38605183; PMCID: PMC11430498.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    6. Exosome-Mediated Impact on Systemic Metabolism. Annu Rev Physiol. 2024 Feb 12; 86:225-253. Cunha E Rocha K, Ying W, Olefsky JM. PMID: 38345906.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    7. Far-red chemigenetic biosensors for multi-dimensional and super-resolved kinase activity imaging. bioRxiv. 2024 Feb 11. Frei MS, Sanchez SA, Liu L, Schneider F, Wang Z, Hakozaki H, Li Y, Lyons AC, Rohm TV, Olefsky JM, Shi L, Schöneberg J, Fraser SE, Mehta S, Wang Y, Zhang J. PMID: 38370804; PMCID: PMC10871310.
      View in: PubMed   Mentions:
    8. Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of atherogenic lipoproteins. Cell Genom. 2023 Jul 12; 3(7):100339. DeForest N, Kavitha B, Hu S, Isaac R, Krohn L, Wang M, Du X, De Arruda Saldanha C, Gylys J, Merli E, Abagyan R, Najmi L, Mohan V, Alnylam Human Genetics, AMP-T2D Consortium, Flannick J, Peloso GM, Gordts PLSM, Heinz S, Deaton AM, Khera AV, Olefsky J, Radha V, Majithia AR. PMID: 37492105; PMCID: PMC10363808.
      View in: PubMed   Mentions: 7     Fields:    
    9. Eating macrophages for a healthy anti-NASH meal. Immunity. 2023 01 10; 56(1):3-5. Lee YS, Olefsky J. PMID: 36630915; PMCID: PMC10441811.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH. Cell Metab. 2022 07 05; 34(7):978-990.e4. Gao H, Jin Z, Bandyopadhyay G, Cunha E Rocha K, Liu X, Zhao H, Zhang D, Jouihan H, Pourshahian S, Kisseleva T, Brenner DA, Ying W, Olefsky JM. PMID: 35700738; PMCID: PMC9262870.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    11. Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth. Nat Cell Biol. 2022 06; 24(6):954-967. Cao M, Isaac R, Yan W, Ruan X, Jiang L, Wan Y, Wang J, Wang E, Caron C, Neben S, Drygin D, Pizzo DP, Wu X, Liu X, Chin AR, Fong MY, Gao Z, Guo K, Fadare O, Schwab RB, Yuan Y, Yost SE, Mortimer J, Zhong W, Ying W, Bui JD, Sears DD, Olefsky JM, Wang SE. PMID: 35637408; PMCID: PMC9233030.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    12. Extracellular Vesicles and Their Emerging Roles as Cellular Messengers in Endocrinology: An Endocrine Society Scientific Statement. Endocr Rev. 2022 05 12; 43(3):441-468. Salomon C, Das S, Erdbrügger U, Kalluri R, Kiang Lim S, Olefsky JM, Rice GE, Sahoo S, Andy Tao W, Vader P, Wang Q, Weaver AM. PMID: 35552682; PMCID: PMC10686249.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    13. Inflammation in obesity, diabetes, and related disorders. Immunity. 2022 01 11; 55(1):31-55. Rohm TV, Meier DT, Olefsky JM, Donath MY. PMID: 35021057; PMCID: PMC8773457.
      View in: PubMed   Mentions: 423     Fields:    Translation:HumansAnimals
    14. Exosomes as mediators of intercellular crosstalk in metabolism. Cell Metab. 2021 09 07; 33(9):1744-1762. Isaac R, Reis FCG, Ying W, Olefsky JM. PMID: 34496230; PMCID: PMC8428804.
      View in: PubMed   Mentions: 216     Fields:    Translation:HumansCells
    15. Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075. Nat Metab. 2021 09; 3(9):1163-1174. Ji Y, Luo Z, Gao H, Dos Reis FCG, Bandyopadhyay G, Jin Z, Manda KA, Isaac R, Yang M, Fu W, Ying W, Olefsky JM. PMID: 34489604; PMCID: PMC8460610.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    16. Chronic tissue inflammation and metabolic disease. Genes Dev. 2021 03 01; 35(5-6):307-328. Lee YS, Olefsky J. PMID: 33649162; PMCID: PMC7919414.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansCells
    17. MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice. Cell Metab. 2021 04 06; 33(4):781-790.e5. Ying W, Gao H, Dos Reis FCG, Bandyopadhyay G, Ofrecio JM, Luo Z, Ji Y, Jin Z, Ly C, Olefsky JM. PMID: 33450179; PMCID: PMC8035248.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    18. Positive Reinforcing Mechanisms between GPR120 and PPARγ Modulate Insulin Sensitivity. Cell Metab. 2020 06 02; 31(6):1173-1188.e5. Paschoal VA, Walenta E, Talukdar S, Pessentheiner AR, Osborn O, Hah N, Chi TJ, Tye GL, Armando AM, Evans RM, Chi NW, Quehenberger O, Olefsky JM, Oh DY. PMID: 32413335; PMCID: PMC7337476.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    19. A Tribute to Robert Roy Henry-The Classic "Academic Triple Threat": Accomplished Researcher, Inspiring Teacher, and Compassionate Clinician. Diabetes Care. 2020 03; 43(3):522-525. Edelman S, Olefsky J, Mudaliar S, Ciaraldi T, Baron A. PMID: 31964787.
      View in: PubMed   Mentions:    Fields:    
    20. The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities. Nat Rev Endocrinol. 2020 02; 16(2):81-90. Ying W, Fu W, Lee YS, Olefsky JM. PMID: 31836875; PMCID: PMC8315273.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansAnimalsCells
    21. Obesity Modulates Intestinal Intraepithelial T Cell Persistence, CD103 and CCR9 Expression, and Outcome in Dextran Sulfate Sodium-Induced Colitis. J Immunol. 2019 12 15; 203(12):3427-3435. Park C, Cheung KP, Limon N, Costanzo A, Barba C, Miranda N, Gargas S, Johnson AMF, Olefsky JM, Jameson JM. PMID: 31712385.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    22. TAZ Is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance. Cell Metab. 2020 01 07; 31(1):162-173.e5. El Ouarrat D, Isaac R, Lee YS, Oh DY, Wollam J, Lackey D, Riopel M, Bandyopadhyay G, Seo JB, Sampath-Kumar R, Olefsky JM. PMID: 31708444; PMCID: PMC7784082.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    23. Microbiota-Produced N-Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance. Diabetes. 2019 07; 68(7):1415-1426. Wollam J, Riopel M, Xu YJ, Johnson AMF, Ofrecio JM, Ying W, El Ouarrat D, Chan LS, Han AW, Mahmood NA, Ryan CN, Lee YS, Watrous JD, Chordia MD, Pan D, Jain M, Olefsky JM. PMID: 31010956; PMCID: PMC6609982.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    24. Role of Host GPR120 in Mediating Dietary Omega-3 Fatty Acid Inhibition of Prostate Cancer. J Natl Cancer Inst. 2019 01 01; 111(1):52-59. Liang P, Henning SM, Guan J, Grogan T, Elashoff D, Olefsky JM, Cohen P, Aronson WJ. PMID: 30202902; PMCID: PMC6335116.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    25. Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity. Cell Metab. 2019 02 05; 29(2):457-474.e5. Ying W, Lee YS, Dong Y, Seidman JS, Yang M, Isaac R, Seo JB, Yang BH, Wollam J, Riopel M, McNelis J, Glass CK, Olefsky JM, Fu W. PMID: 30595478; PMCID: PMC6701710.
      View in: PubMed   Mentions: 119     Fields:    Translation:AnimalsCells
    26. Neuronal SIRT1 Regulates Metabolic and Reproductive Function and the Response to Caloric Restriction. J Endocr Soc. 2019 Feb 01; 3(2):427-445. Rickert E, Fernandez MO, Choi I, Gorman M, Olefsky JM, Webster NJG. PMID: 30746504; PMCID: PMC6364627.
      View in: PubMed   Mentions: 5  
    27. CX3CL1-Fc treatment prevents atherosclerosis in Ldlr KO mice. Mol Metab. 2019 02; 20:89-101. Riopel M, Vassallo M, Ehinger E, Pattison J, Bowden K, Winkels H, Wilson M, de Jong R, Patel S, Balakrishna D, Bilakovics J, Fanjul A, Plonowski A, Larson CJ, Ley K, Cabrales P, Witztum JL, Olefsky JM, Lee YS. PMID: 30553772; PMCID: PMC6358552.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    28. Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity. Nat Metab. 2019 01; 1(1):86-97. Seo JB, Riopel M, Cabrales P, Huh JY, Bandyopadhyay GK, Andreyev AY, Murphy AN, Beeman SC, Smith GI, Klein S, Lee YS, Olefsky JM. PMID: 31528845; PMCID: PMC6746433.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    29. N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model. Bioorg Med Chem. 2018 10 01; 26(18):5169-5180. Hoveyda HR, Fraser GL, Zoute L, Dutheuil G, Schils D, Brantis C, Lapin A, Parcq J, Guitard S, Lenoir F, Bousmaqui ME, Rorive S, Hospied S, Blanc S, Bernard J, Ooms F, McNelis JC, Olefsky JM. PMID: 30253886.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    30. Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis. Arthritis Res Ther. 2018 07 11; 20(1):145. Korman B, Marangoni RG, Lord G, Olefsky J, Tourtellotte W, Varga J. PMID: 29996896; PMCID: PMC6042240.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    31. RalA controls glucose homeostasis by regulating glucose uptake in brown fat. Proc Natl Acad Sci U S A. 2018 07 24; 115(30):7819-7824. Skorobogatko Y, Dragan M, Cordon C, Reilly SM, Hung CW, Xia W, Zhao P, Wallace M, Lackey DE, Chen XW, Osborn O, Bogner-Strauss JG, Theodorescu D, Metallo CM, Olefsky JM, Saltiel AR. PMID: 29915037; PMCID: PMC6065037.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    32. Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function. J Clin Invest. 2018 04 02; 128(4):1458-1470. Riopel M, Seo JB, Bandyopadhyay GK, Li P, Wollam J, Chung H, Jung SR, Murphy A, Wilson M, de Jong R, Patel S, Balakrishna D, Bilakovics J, Fanjul A, Plonowski A, Koh DS, Larson CJ, Olefsky JM, Lee YS. PMID: 29504946; PMCID: PMC5873865.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    33. An Integrated View of Immunometabolism. Cell. 2018 01 11; 172(1-2):22-40. Lee YS, Wollam J, Olefsky JM. PMID: 29328913; PMCID: PMC8451723.
      View in: PubMed   Mentions: 206     Fields:    Translation:HumansAnimals
    34. Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity. Cell. 2017 Oct 05; 171(2):372-384.e12. Ying W, Riopel M, Bandyopadhyay G, Dong Y, Birmingham A, Seo JB, Ofrecio JM, Wollam J, Hernandez-Carretero A, Fu W, Li P, Olefsky JM. PMID: 28942920.
      View in: PubMed   Mentions: 577     Fields:    Translation:AnimalsCells
    35. Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling. J Clin Invest. 2017 Mar 01; 127(3):1019-1030. Ying W, Wollam J, Ofrecio JM, Bandyopadhyay G, El Ouarrat D, Lee YS, Oh DY, Li P, Osborn O, Olefsky JM. PMID: 28192375; PMCID: PMC5330737.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    36. Inflammatory mechanisms linking obesity and metabolic disease. J Clin Invest. 2017 01 03; 127(1):1-4. Saltiel AR, Olefsky JM. PMID: 28045402; PMCID: PMC5199709.
      View in: PubMed   Mentions: 822     Fields:    Translation:HumansAnimals
    37. Obese Neuronal PPARγ Knockout Mice Are Leptin Sensitive but Show Impaired Glucose Tolerance and Fertility. Endocrinology. 2017 01 01; 158(1):121-133. Fernandez MO, Sharma S, Kim S, Rickert E, Hsueh K, Hwang V, Olefsky JM, Webster NJ. PMID: 27841948; PMCID: PMC5412981.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    38. Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Cell. 2016 11 03; 167(4):973-984.e12. Li P, Liu S, Lu M, Bandyopadhyay G, Oh D, Imamura T, Johnson AMF, Sears D, Shen Z, Cui B, Kong L, Hou S, Liang X, Iovino S, Watkins SM, Ying W, Osborn O, Wollam J, Brenner M, Olefsky JM. PMID: 27814523; PMCID: PMC5179329.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansAnimalsCells
    39. G protein-coupled receptors as targets for anti-diabetic therapeutics. Nat Rev Drug Discov. 2016 03; 15(3):161-72. Oh DY, Olefsky JM. PMID: 26822831.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    40. p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Rep. 2016 Jan 12; 14(2):255-68. Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor SS, Houslay MD, Baillie GS, Saltiel AR, Olefsky JM, Akassoglou K. PMID: 26748707; PMCID: PMC4831919.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    41. Regulation of metabolism by the innate immune system. Nat Rev Endocrinol. 2016 Jan; 12(1):15-28. Lackey DE, Olefsky JM. PMID: 26553134.
      View in: PubMed   Mentions: 301     Fields:    Translation:HumansAnimals
    42. Spatial Cognition in Adult and Aged Mice Exposed to High-Fat Diet. PLoS One. 2015; 10(10):e0140034. Kesby JP, Kim JJ, Scadeng M, Woods G, Kado DM, Olefsky JM, Jeste DV, Achim CL, Semenova S. PMID: 26448649; PMCID: PMC4598128.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    43. GPR43 Potentiates β-Cell Function in Obesity. Diabetes. 2015 Sep; 64(9):3203-17. McNelis JC, Lee YS, Mayoral R, van der Kant R, Johnson AM, Wollam J, Olefsky JM. PMID: 26023106; PMCID: PMC4542437.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    44. High fat diet causes depletion of intestinal eosinophils associated with intestinal permeability. PLoS One. 2015; 10(4):e0122195. Johnson AM, Costanzo A, Gareau MG, Armando AM, Quehenberger O, Jameson JM, Olefsky JM. PMID: 25837594; PMCID: PMC4383570.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    45. Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity. Mol Metab. 2015 May; 4(5):378-91. Mayoral R, Osborn O, McNelis J, Johnson AM, Oh DY, Izquierdo CL, Chung H, Li P, Traves PG, Bandyopadhyay G, Pessentheiner AR, Ofrecio JM, Cook JR, Qiang L, Accili D, Olefsky JM. PMID: 25973386; PMCID: PMC4421024.
      View in: PubMed   Mentions: 80     Fields:    
    46. Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature. 2015 Apr 16; 520(7547):388. Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky JM, Mohammadi M, Downes M, Evans RM. PMID: 25739500.
      View in: PubMed   Mentions: 3     Fields:    
    47. LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes. Nat Med. 2015 Mar; 21(3):239-247. Li P, Oh DY, Bandyopadhyay G, Lagakos WS, Talukdar S, Osborn O, Johnson A, Chung H, Maris M, Ofrecio JM, Taguchi S, Lu M, Olefsky JM. PMID: 25706874; PMCID: PMC4429798.
      View in: PubMed   Mentions: 154     Fields:    Translation:AnimalsCells
    48. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb; 21(2):159-65. Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M, Evans RM. PMID: 25559344; PMCID: PMC4320010.
      View in: PubMed   Mentions: 321     Fields:    Translation:Animals
    49. Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice. Diabetes. 2015 Apr; 64(4):1120-30. Morinaga H, Mayoral R, Heinrichsdorff J, Osborn O, Franck N, Hah N, Walenta E, Bandyopadhyay G, Pessentheiner AR, Chi TJ, Chung H, Bogner-Strauss JG, Evans RM, Olefsky JM, Oh DY. PMID: 25315009; PMCID: PMC4375077.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    50. Omega-3 fatty acids reduce obesity-induced tumor progression independent of GPR120 in a mouse model of postmenopausal breast cancer. Oncogene. 2015 Jul; 34(27):3504-13. Chung H, Lee YS, Mayoral R, Oh DY, Siu JT, Webster NJ, Sears DD, Olefsky JM, Ellies LG. PMID: 25220417; PMCID: PMC4362785.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    51. Macrophages, immunity, and metabolic disease. Immunity. 2014 Jul 17; 41(1):36-48. McNelis JC, Olefsky JM. PMID: 25035952.
      View in: PubMed   Mentions: 345     Fields:    Translation:HumansAnimalsCells
    52. Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature. 2014 Sep 18; 513(7518):436-9. Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky JM, Mohammadi M, Downes M, Evans RM. PMID: 25043058; PMCID: PMC4184286.
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    116. Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest. 2008 Sep; 118(9):2992-3002. Schenk S, Saberi M, Olefsky JM. PMID: 18769626; PMCID: PMC2522344.
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    117. Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cells. Proc Natl Acad Sci U S A. 2008 May 06; 105(18):6614-9. Sonoda N, Imamura T, Yoshizaki T, Babendure JL, Lu JC, Olefsky JM. PMID: 18445652; PMCID: PMC2373360.
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    118. Blockade of alpha4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesity. Diabetes. 2008 Jul; 57(7):1842-51. Féral CC, Neels JG, Kummer C, Slepak M, Olefsky JM, Ginsberg MH. PMID: 18426864; PMCID: PMC2453617.
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    119. Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. Nature. 2008 Feb 21; 451(7181):964-9. Yang X, Ongusaha PP, Miles PD, Havstad JC, Zhang F, So WV, Kudlow JE, Michell RH, Olefsky JM, Field SJ, Evans RM. PMID: 18288188.
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    120. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29; 450(7170):712-6. Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH. PMID: 18046409; PMCID: PMC2753457.
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    121. Inflammation and insulin resistance. FEBS Lett. 2008 Jan 09; 582(1):97-105. de Luca C, Olefsky JM. PMID: 18053812; PMCID: PMC2246086.
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    122. Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes. Mol Endocrinol. 2008 Mar; 22(3):760-71. Lu M, Tang Q, Olefsky JM, Mellon PL, Webster NJ. PMID: 18006641; PMCID: PMC2262174.
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    123. JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab. 2007 Nov; 6(5):386-97. Solinas G, Vilcu C, Neels JG, Bandyopadhyay GK, Luo JL, Naugler W, Grivennikov S, Wynshaw-Boris A, Scadeng M, Olefsky JM, Karin M. PMID: 17983584.
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    124. Selective modulation of promoter recruitment and transcriptional activity of PPARgamma. Biochem Biophys Res Commun. 2007 Dec 21; 364(3):515-21. Sears DD, Hsiao A, Ofrecio JM, Chapman J, He W, Olefsky JM. PMID: 17963725; PMCID: PMC2585742.
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    125. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem. 2007 Nov 30; 282(48):35279-92. Nguyen MT, Favelyukis S, Nguyen AK, Reichart D, Scott PA, Jenn A, Liu-Bryan R, Glass CK, Neels JG, Olefsky JM. PMID: 17916553.
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    126. Tumor necrosis factor receptor-1 can function through a G alpha q/11-beta-arrestin-1 signaling complex. J Biol Chem. 2007 Sep 28; 282(39):28549-28556. Kawamata Y, Imamura T, Babendure JL, Lu JC, Yoshizaki T, Olefsky JM. PMID: 17664271.
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    127. Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest. 2007 Jun; 117(6):1658-69. Hevener AL, Olefsky JM, Reichart D, Nguyen MT, Bandyopadyhay G, Leung HY, Watt MJ, Benner C, Febbraio MA, Nguyen AK, Folian B, Subramaniam S, Gonzalez FJ, Glass CK, Ricote M. PMID: 17525798; PMCID: PMC1868788.
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    128. Myosin 5a is an insulin-stimulated Akt2 (protein kinase Bbeta) substrate modulating GLUT4 vesicle translocation. Mol Cell Biol. 2007 Jul; 27(14):5172-83. Yoshizaki T, Imamura T, Babendure JL, Lu JC, Sonoda N, Olefsky JM. PMID: 17515613; PMCID: PMC1951956.
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    129. Suppression of PPAR-gamma attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab. 2007 Jul; 293(1):E219-27. Liao W, Nguyen MT, Yoshizaki T, Favelyukis S, Patsouris D, Imamura T, Verma IM, Olefsky JM. PMID: 17389706.
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    130. Impaired insulin secretion in a mouse model of ataxia telangiectasia. Am J Physiol Endocrinol Metab. 2007 Jul; 293(1):E70-4. Miles PD, Treuner K, Latronica M, Olefsky JM, Barlow C. PMID: 17356010.
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    131. Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance. Nat Med. 2007 Apr; 13(4):455-62. Lesniewski LA, Hosch SE, Neels JG, de Luca C, Pashmforoush M, Lumeng CN, Chiang SH, Scadeng M, Saltiel AR, Olefsky JM. PMID: 17351624.
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    132. Regulation of receptor tyrosine kinase signaling by GRKs and beta-arrestins. Annu Rev Physiol. 2007; 69:561-77. Hupfeld CJ, Olefsky JM. PMID: 17002595.
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    133. The US's changing competitiveness in the biomedical sciences. J Clin Invest. 2007 Jan; 117(1):270-6. Olefsky JM. PMID: 17200723; PMCID: PMC1751294.
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    134. Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects. Diabetes. 2006 Aug; 55(8):2277-85. Bandyopadhyay GK, Yu JG, Ofrecio J, Olefsky JM. PMID: 16873691.
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    135. APPLied mechanics: uncovering how adiponectin modulates insulin action. Cell Metab. 2006 Jul; 4(1):5-6. Hosch SE, Olefsky JM, Kim JJ. PMID: 16814726.
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    136. Cell signaling. A new way to burn fat. Science. 2006 Jun 23; 312(5781):1756-8. Neels JG, Olefsky JM. PMID: 16794069.
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    137. Lentiviral short hairpin ribonucleic acid-mediated knockdown of GLUT4 in 3T3-L1 adipocytes. Endocrinology. 2006 May; 147(5):2245-52. Liao W, Nguyen MT, Imamura T, Singer O, Verma IM, Olefsky JM. PMID: 16497797.
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    138. PPARdelta regulates glucose metabolism and insulin sensitivity. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3444-9. Lee CH, Olson P, Hevener A, Mehl I, Chong LW, Olefsky JM, Gonzalez FJ, Ham J, Kang H, Peters JM, Evans RM. PMID: 16492734; PMCID: PMC1413918.
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    139. Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras. EMBO J. 2006 Mar 08; 25(5):1093-103. Shin SY, Bahk YY, Ko J, Chung IY, Lee YS, Downward J, Eibel H, Sharma PM, Olefsky JM, Kim YH, Lee B, Lee YH. PMID: 16456537; PMCID: PMC1409727.
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    140. Stressed out about obesity and insulin resistance. Nat Med. 2006 Jan; 12(1):41-2; discussion 42. de Luca C, Olefsky JM. PMID: 16397561.
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    141. Inflamed fat: what starts the fire? J Clin Invest. 2006 Jan; 116(1):33-5. Neels JG, Olefsky JM. PMID: 16395402; PMCID: PMC1323268.
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    142. Disruption of microtubules ablates the specificity of insulin signaling to GLUT4 translocation in 3T3-L1 adipocytes. J Biol Chem. 2005 Dec 23; 280(51):42300-6. Huang J, Imamura T, Babendure JL, Lu JC, Olefsky JM. PMID: 16239226.
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    143. Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature. 2005 Sep 22; 437(7058):569-73. Zhang J, Hupfeld CJ, Taylor SS, Olefsky JM, Tsien RY. PMID: 16177793.
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    144. Synthesis and evaluation of photolabile insulin prodrugs. Bioorg Med Chem Lett. 2005 Sep 01; 15(17):3917-20. Li LS, Babendure JL, Sinha SC, Olefsky JM, Lerner RA. PMID: 15993597.
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    145. JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. J Biol Chem. 2005 Oct 21; 280(42):35361-71. Nguyen MT, Satoh H, Favelyukis S, Babendure JL, Imamura T, Sbodio JI, Zalevsky J, Dahiyat BI, Chi NW, Olefsky JM. PMID: 16085647.
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    146. Topiramate treatment causes skeletal muscle insulin sensitization and increased Acrp30 secretion in high-fat-fed male Wistar rats. Am J Physiol Endocrinol Metab. 2005 Dec; 289(6):E1015-22. Wilkes JJ, Nguyen MT, Bandyopadhyay GK, Nelson E, Olefsky JM. PMID: 16030065.
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    147. VAMPIRE microarray suite: a web-based platform for the interpretation of gene expression data. Nucleic Acids Res. 2005 Jul 01; 33(Web Server issue):W627-32. Hsiao A, Ideker T, Olefsky JM, Subramaniam S. PMID: 15980550; PMCID: PMC1160204.
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    148. G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes. Mol Endocrinol. 2005 Nov; 19(11):2760-8. Usui I, Imamura T, Babendure JL, Satoh H, Lu JC, Hupfeld CJ, Olefsky JM. PMID: 15994203.
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    149. Adenovirus-mediated adiponectin expression augments skeletal muscle insulin sensitivity in male Wistar rats. Diabetes. 2005 May; 54(5):1304-13. Satoh H, Nguyen MT, Trujillo M, Imamura T, Usui I, Scherer PE, Olefsky JM. PMID: 15855314.
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    150. Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action. Nat Med. 2005 May; 11(5):567-71. Bard-Chapeau EA, Hevener AL, Long S, Zhang EE, Olefsky JM, Feng GS. PMID: 15821749.
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    151. Variation in the gene for muscle-specific AMP deaminase is associated with insulin clearance, a highly heritable trait. Diabetes. 2005 Apr; 54(4):1222-7. Goodarzi MO, Taylor KD, Guo X, Quiñones MJ, Cui J, Li X, Hang T, Yang H, Holmes E, Hsueh WA, Olefsky J, Rotter JI. PMID: 15793265.
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    152. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med. 2005 Feb; 11(2):191-8. Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M. PMID: 15685170.
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    153. Topiramate is an insulin-sensitizing compound in vivo with direct effects on adipocytes in female ZDF rats. Am J Physiol Endocrinol Metab. 2005 Mar; 288(3):E617-24. Wilkes JJ, Nelson E, Osborne M, Demarest KT, Olefsky JM. PMID: 15536205.
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    154. Insulin-induced beta-arrestin1 Ser-412 phosphorylation is a mechanism for desensitization of ERK activation by Galphai-coupled receptors. J Biol Chem. 2005 Jan 14; 280(2):1016-23. Hupfeld CJ, Resnik JL, Ugi S, Olefsky JM. PMID: 15520010.
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    155. Mechanism of SHIP-mediated inhibition of insulin- and platelet-derived growth factor-stimulated mitogen-activated protein kinase activity in 3T3-L1 adipocytes. Mol Endocrinol. 2005 Feb; 19(2):421-30. Sharma PM, Son HS, Ugi S, Ricketts W, Olefsky JM. PMID: 15486046.
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    156. beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1. Mol Cell Biol. 2004 Oct; 24(20):8929-37. Usui I, Imamura T, Huang J, Satoh H, Shenoy SK, Lefkowitz RJ, Hupfeld CJ, Olefsky JM. PMID: 15456867; PMCID: PMC517874.
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    157. Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes. Mol Cell Biol. 2004 Oct; 24(19):8778-89. Ugi S, Imamura T, Maegawa H, Egawa K, Yoshizaki T, Shi K, Obata T, Ebina Y, Kashiwagi A, Olefsky JM. PMID: 15367694; PMCID: PMC516764.
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    158. Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3). Proc Natl Acad Sci U S A. 2004 Sep 07; 101(36):13296-301. Wiedmer T, Zhao J, Li L, Zhou Q, Hevener A, Olefsky JM, Curtiss LK, Sims PJ. PMID: 15328404; PMCID: PMC516563.
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    159. GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation. EMBO J. 2004 Jul 21; 23(14):2821-9. Usui I, Imamura T, Satoh H, Huang J, Babendure JL, Hupfeld CJ, Olefsky JM. PMID: 15241473; PMCID: PMC514955.
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    160. Adenovirus-mediated chronic "hyper-resistinemia" leads to in vivo insulin resistance in normal rats. J Clin Invest. 2004 Jul; 114(2):224-31. Satoh H, Nguyen MT, Miles PD, Imamura T, Usui I, Olefsky JM. PMID: 15254589; PMCID: PMC449745.
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    161. Variance-modeled posterior inference of microarray data: detecting gene-expression changes in 3T3-L1 adipocytes. Bioinformatics. 2004 Nov 22; 20(17):3108-27. Hsiao A, Worrall DS, Olefsky JM, Subramaniam S. PMID: 15217816.
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    162. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat Med. 2004 May; 10(5):530-4. Koo SH, Satoh H, Herzig S, Lee CH, Hedrick S, Kulkarni R, Evans RM, Olefsky J, Montminy M. PMID: 15107844.
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    163. Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. J Biol Chem. 2004 May 21; 279(21):22715-26. Yoshizaki T, Maegawa H, Egawa K, Ugi S, Nishio Y, Imamura T, Kobayashi T, Tamura S, Olefsky JM, Kashiwagi A. PMID: 15016818.
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    164. Annexin II is a thiazolidinedione-responsive gene involved in insulin-induced glucose transporter isoform 4 translocation in 3T3-L1 adipocytes. Endocrinology. 2004 Apr; 145(4):1579-86. Huang J, Hsia SH, Imamura T, Usui I, Olefsky JM. PMID: 14726447.
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    165. Regulation of the insulin receptor by protein kinase C isoenzymes: preferential interaction with beta isoenzymes and interaction with the catalytic domain of betaII. Cell Signal. 2004 Jan; 16(1):97-104. Pillay TS, Xiao S, Keranen L, Olefsky JM. PMID: 14607280.
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    166. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem. 2004 Mar 26; 279(13):12152-62. Pajvani UB, Hawkins M, Combs TP, Rajala MW, Doebber T, Berger JP, Wagner JA, Wu M, Knopps A, Xiang AH, Utzschneider KM, Kahn SE, Olefsky JM, Buchanan TA, Scherer PE. PMID: 14699128.
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    167. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15712-7. He W, Barak Y, Hevener A, Olson P, Liao D, Le J, Nelson M, Ong E, Olefsky JM, Evans RM. PMID: 14660788; PMCID: PMC307633.
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    168. Muscle-specific Pparg deletion causes insulin resistance. Nat Med. 2003 Dec; 9(12):1491-7. Hevener AL, He W, Barak Y, Le J, Bandyopadhyay G, Olson P, Wilkes J, Evans RM, Olefsky J. PMID: 14625542.
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    169. Cellular effects of small molecule PTP1B inhibitors on insulin signaling. Biochemistry. 2003 Nov 11; 42(44):12792-804. Xie L, Lee SY, Andersen JN, Waters S, Shen K, Guo XL, Moller NP, Olefsky JM, Lawrence DS, Zhang ZY. PMID: 14596593.
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    170. Chronic endothelin-1 treatment leads to insulin resistance in vivo. Diabetes. 2003 Aug; 52(8):1904-9. Wilkes JJ, Hevener A, Olefsky J. PMID: 12882904.
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    171. Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin. Mol Cell Biol. 2003 Jul; 23(14):4892-900. Imamura T, Huang J, Usui I, Satoh H, Bever J, Olefsky JM. PMID: 12832475; PMCID: PMC162221.
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    172. The effect of oral glucosamine sulfate on insulin sensitivity in human subjects. Diabetes Care. 2003 Jun; 26(6):1941-2. Yu JG, Boies SM, Olefsky JM. PMID: 12766141.
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    173. Inhibition of mitochondrial Na+-Ca2+ exchanger increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets. Diabetes. 2003 Apr; 52(4):965-73. Lee B, Miles PD, Vargas L, Luan P, Glasco S, Kushnareva Y, Kornbrust ES, Grako KA, Wollheim CB, Maechler P, Olefsky JM, Anderson CM. PMID: 12663468.
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    174. Effect of heterozygous PPARgamma deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding. Am J Physiol Endocrinol Metab. 2003 Mar; 284(3):E618-26. Miles PD, Barak Y, Evans RM, Olefsky JM. PMID: 12556354.
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    175. Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3T3-L1 adipocytes. J Biol Chem. 2003 Apr 18; 278(16):13765-74. Usui I, Imamura T, Huang J, Satoh H, Olefsky JM. PMID: 12566459.
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    176. Effect of obesity on susceptibility to fatty acid-induced peripheral tissue insulin resistance. Metabolism. 2003 Feb; 52(2):233-8. Kruszynska YT, Olefsky JM, Frias JP. PMID: 12601639.
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    177. Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A. 2003 Jan 07; 100(1):161-6. Hupfeld CJ, Dalle S, Olefsky JM. PMID: 12509508; PMCID: PMC140914.
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    178. Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistance. Diabetes. 2002 Nov; 51(11):3176-88. Ruan H, Miles PD, Ladd CM, Ross K, Golub TR, Olefsky JM, Lodish HF. PMID: 12401708.
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    179. The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. Diabetes. 2002 Oct; 51(10):2968-74. Yu JG, Javorschi S, Hevener AL, Kruszynska YT, Norman RA, Sinha M, Olefsky JM. PMID: 12351435.
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    180. Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1. Mol Cell Biol. 2002 Sep; 22(17):6272-85. Dalle S, Imamura T, Rose DW, Worrall DS, Ugi S, Hupfeld CJ, Olefsky JM. PMID: 12167719; PMCID: PMC134007.
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    181. Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells. J Biol Chem. 2002 Aug 30; 277(35):32099-108. Liu F, Usui I, Evans LG, Austin DA, Mellon PL, Olefsky JM, Webster NJ. PMID: 12050161; PMCID: PMC2930616.
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    182. Female rats do not exhibit free fatty acid-induced insulin resistance. Diabetes. 2002 Jun; 51(6):1907-12. Hevener A, Reichart D, Janez A, Olefsky J. PMID: 12031980.
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    183. Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups. Am J Hum Genet. 2002 May; 70(5):1152-71. Herrnstadt C, Elson JL, Fahy E, Preston G, Turnbull DM, Anderson C, Ghosh SS, Olefsky JM, Beal MF, Davis RE, Howell N. PMID: 11938495; PMCID: PMC447592.
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    184. Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling. Mol Cell Biol. 2002 Apr; 22(7):2375-87. Ugi S, Imamura T, Ricketts W, Olefsky JM. PMID: 11884620; PMCID: PMC133677.
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    185. Phosphatidylinositol 3-kinase is required for insulin-stimulated tyrosine phosphorylation of Shc in 3T3-L1 adipocytes. J Biol Chem. 2002 May 24; 277(21):18592-7. Ugi S, Sharma PM, Ricketts W, Imamura T, Olefsky JM. PMID: 11897789.
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    186. GnRH activates ERK1/2 leading to the induction of c-fos and LHbeta protein expression in LbetaT2 cells. Mol Endocrinol. 2002 Mar; 16(3):419-34. Liu F, Austin DA, Mellon PL, Olefsky JM, Webster NJ. PMID: 11875099.
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    187. The effects of intracellular calcium depletion on insulin signaling in 3T3-L1 adipocytes. Mol Endocrinol. 2002 Feb; 16(2):378-89. Worrall DS, Olefsky JM. PMID: 11818508.
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    188. Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation. J Clin Endocrinol Metab. 2002 Jan; 87(1):226-34. Kruszynska YT, Worrall DS, Ofrecio J, Frias JP, Macaraeg G, Olefsky JM. PMID: 11788651.
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    189. Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):303-8. Barak Y, Liao D, He W, Ong ES, Nelson MC, Olefsky JM, Boland R, Evans RM. PMID: 11756685; PMCID: PMC117556.
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    190. Synthesis of an organoinsulin molecule that can be activated by antibody catalysis. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13514-8. Worrall DS, McDunn JE, List B, Reichart D, Hevener A, Gustafson T, Barbas CF, Lerner RA, Olefsky JM. PMID: 11707596; PMCID: PMC61072.
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    191. Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein. Proc Natl Acad Sci U S A. 2001 Nov 06; 98(23):13084-9. Huang J, Imamura T, Olefsky JM. PMID: 11687655; PMCID: PMC60828.
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    192. Thiazolidinedione treatment prevents free fatty acid-induced insulin resistance in male wistar rats. Diabetes. 2001 Oct; 50(10):2316-22. Hevener AL, Reichart D, Janez A, Olefsky J. PMID: 11574414.
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    193. beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport. J Biol Chem. 2001 Nov 23; 276(47):43663-7. Imamura T, Huang J, Dalle S, Ugi S, Usui I, Luttrell LM, Miller WE, Lefkowitz RJ, Olefsky JM. PMID: 11546805.
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    194. Nuclear receptor minireview series. J Biol Chem. 2001 Oct 05; 276(40):36863-4. Olefsky JM. PMID: 11459855.
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    195. Decreased susceptibility to fatty acid-induced peripheral tissue insulin resistance in women. Diabetes. 2001 Jun; 50(6):1344-50. Frias JP, Macaraeg GB, Ofrecio J, Yu JG, Olefsky JM, Kruszynska YT. PMID: 11375335.
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    196. Chronic endothelin-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytes. J Clin Invest. 2001 May; 107(9):1193-202. Ishibashi KI, Imamura T, Sharma PM, Huang J, Ugi S, Olefsky JM. PMID: 11342583; PMCID: PMC209278.
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    197. Insulin and insulin-like growth factor I receptors utilize different G protein signaling components. J Biol Chem. 2001 May 11; 276(19):15688-95. Dalle S, Ricketts W, Imamura T, Vollenweider P, Olefsky JM. PMID: 11278773.
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    198. Prospects for research in diabetes mellitus. JAMA. 2001 Feb 07; 285(5):628-32. Olefsky JM. PMID: 11176871.
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    199. Insulin signals to prenyltransferases via the Shc branch of intracellular signaling. J Biol Chem. 2001 Apr 20; 276(16):12805-12. Goalstone ML, Leitner JW, Berhanu P, Sharma PM, Olefsky JM, Draznin B. PMID: 11278505.
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    200. Exercise-stimulated glucose turnover in the rat is impaired by glucosamine infusion. Diabetes. 2001 Jan; 50(1):139-42. Miles PD, Higo K, Olefsky JM. PMID: 11147779.
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    201. The acute and chronic stimulatory effects of endothelin-1 on glucose transport are mediated by distinct pathways in 3T3-L1 adipocytes. Endocrinology. 2000 Dec; 141(12):4623-8. Ishibashi K, Imamura T, Sharma PM, Ugi S, Olefsky JM. PMID: 11108276.
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    202. Insulin-mediated cellular insulin resistance decreases osmotic shock-induced glucose transport in 3T3-L1 adipocytes. Endocrinology. 2000 Dec; 141(12):4657-63. Janez A, Worrall DS, Olefsky JM. PMID: 11108280.
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    203. Exercise and thiazolidinedione therapy normalize insulin action in the obese Zucker fatty rat. Diabetes. 2000 Dec; 49(12):2154-9. Hevener AL, Reichart D, Olefsky J. PMID: 11118020.
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    204. Diabetes. Gene therapy for rats and mice. Nature. 2000 Nov 23; 408(6811):420-1. Olefsky JM. PMID: 11100710.
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    205. PPAR gamma and the treatment of insulin resistance. Trends Endocrinol Metab. 2000 Nov; 11(9):362-8. Olefsky JM, Saltiel AR. PMID: 11042466.
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    206. The osmotic shock-induced glucose transport pathway in 3T3-L1 adipocytes is mediated by gab-1 and requires Gab-1-associated phosphatidylinositol 3-kinase activity for full activation. J Biol Chem. 2000 Sep 01; 275(35):26870-6. Janez A, Worrall DS, Imamura T, Sharma PM, Olefsky JM. PMID: 10842168.
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    207. Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists. J Clin Invest. 2000 Aug; 106(4):467-72. Olefsky JM. PMID: 10953021; PMCID: PMC380259.
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    208. A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. Mol Endocrinol. 2000 Jun; 14(6):783-94. Haruta T, Uno T, Kawahara J, Takano A, Egawa K, Sharma PM, Olefsky JM, Kobayashi M. PMID: 10847581.
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    209. Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes. Endocrinology. 2000 Jun; 141(6):1930-5. Egawa K, Nakashima N, Sharma PM, Maegawa H, Nagai Y, Kashiwagi A, Kikkawa R, Olefsky JM. PMID: 10830273.
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    210. The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes. J Biol Chem. 2000 Apr 28; 275(17):12889-95. Nakashima N, Sharma PM, Imamura T, Bookstein R, Olefsky JM. PMID: 10777587.
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    211. Effects of insulin on prenylation as a mechanism of potentially detrimental influence of hyperinsulinemia. Endocrinology. 2000 Apr; 141(4):1310-6. Draznin B, Miles P, Kruszynska Y, Olefsky J, Friedman J, Golovchenko I, Stjernholm R, Wall K, Reitman M, Accili D, Cooksey R, McClain D, Goalstone M. PMID: 10746633.
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    212. Effects of troglitazone on blood concentrations of plasminogen activator inhibitor 1 in patients with type 2 diabetes and in lean and obese normal subjects. Diabetes. 2000 Apr; 49(4):633-9. Kruszynska YT, Yu JG, Olefsky JM, Sobel BE. PMID: 10871202.
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    213. Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency. J Clin Invest. 2000 Feb; 105(3):287-92. Miles PD, Barak Y, He W, Evans RM, Olefsky JM. PMID: 10675354; PMCID: PMC377448.
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    214. Metabolic effects of troglitazone therapy in type 2 diabetic, obese, and lean normal subjects. Diabetes Care. 2000 Jan; 23(1):64-9. Frias JP, Yu JG, Kruszynska YT, Olefsky JM. PMID: 10857970.
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    215. A comparison of troglitazone and metformin on insulin requirements in euglycemic intensively insulin-treated type 2 diabetic patients. Diabetes. 1999 Dec; 48(12):2414-21. Yu JG, Kruszynska YT, Mulford MI, Olefsky JM. PMID: 10580431.
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    216. Pertussis toxin-sensitive and -insensitive thrombin stimulation of Shc phosphorylation and mitogenesis are mediated through distinct pathways. Mol Endocrinol. 1999 Dec; 13(12):1988-2001. Ricketts WA, Brown JH, Olefsky JM. PMID: 10598576.
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    217. Endothelin-1-induced GLUT4 translocation is mediated via Galpha(q/11) protein and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. J Biol Chem. 1999 Nov 19; 274(47):33691-5. Imamura T, Ishibashi K, Dalle S, Ugi S, Olefsky JM. PMID: 10559259.
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    218. G alpha-q/11 protein plays a key role in insulin-induced glucose transport in 3T3-L1 adipocytes. Mol Cell Biol. 1999 Oct; 19(10):6765-74. Imamura T, Vollenweider P, Egawa K, Clodi M, Ishibashi K, Nakashima N, Ugi S, Adams JW, Brown JH, Olefsky JM. PMID: 10490615; PMCID: PMC84673.
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    219. Inhibition of PLC-gamma1 activity converts nerve growth factor from an anti-mitogenic to a mitogenic signal in CHO cells. Oncogene. 1999 Sep 02; 18(35):4908-19. Zapf-Colby A, Eichhorn J, Webster NJ, Olefsky JM. PMID: 10490825.
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    220. Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance. J Biol Chem. 1999 May 14; 274(20):14306-14. Egawa K, Sharma PM, Nakashima N, Huang Y, Huver E, Boss GR, Olefsky JM. PMID: 10318852.
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    221. An SH2 domain-containing 5' inositolphosphatase inhibits insulin-induced GLUT4 translocation and growth factor-induced actin filament rearrangement. Mol Cell Biol. 1999 Feb; 19(2):1081-91. Vollenweider P, Clodi M, Martin SS, Imamura T, Kavanaugh WM, Olefsky JM. PMID: 9891043; PMCID: PMC116038.
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    222. The functional role of CrkII in actin cytoskeleton organization and mitogenesis. J Biol Chem. 1999 Jan 29; 274(5):3001-8. Nakashima N, Rose DW, Xiao S, Egawa K, Martin SS, Haruta T, Saltiel AR, Olefsky JM. PMID: 9915838.
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    223. Insulin-stimulated glucose transport minireview series. J Biol Chem. 1999 Jan 22; 274(4):1863. Olefsky JM. PMID: 9890934.
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    224. Effects of general receptor for phosphoinositides 1 on insulin and insulin-like growth factor I-induced cytoskeletal rearrangement, glucose transporter-4 translocation, and deoxyribonucleic acid synthesis. Endocrinology. 1998 Dec; 139(12):4984-90. Clodi M, Vollenweider P, Klarlund J, Nakashima N, Martin S, Czech MP, Olefsky JM. PMID: 9832437.
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    225. Platelet-derived growth factor inhibits insulin stimulation of insulin receptor substrate-1-associated phosphatidylinositol 3-kinase in 3T3-L1 adipocytes without affecting glucose transport. J Biol Chem. 1998 Sep 25; 273(39):25139-47. Staubs PA, Nelson JG, Reichart DR, Olefsky JM. PMID: 9737973.
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    226. Prolonged vs transient roles for early cell cycle signaling components. Oncogene. 1998 Aug 20; 17(7):889-99. Rose DW, Xiao S, Pillay TS, Kolch W, Olefsky JM. PMID: 9780005.
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    227. Lack of insulin resistance in fibroblasts from subjects with polycystic ovary syndrome. Metabolism. 1998 Aug; 47(8):940-6. Ciaraldi TP, Morales AJ, Hickman MG, Odom-Ford R, Yen SS, Olefsky JM. PMID: 9711989.
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    228. Inhibition of phosphatidylinositol 3-kinase activity by adenovirus-mediated gene transfer and its effect on insulin action. J Biol Chem. 1998 Jul 17; 273(29):18528-37. Sharma PM, Egawa K, Huang Y, Martin JL, Huvar I, Boss GR, Olefsky JM. PMID: 9660823.
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    229. Nerve growth factor processing and trafficking events following TrkA-mediated endocytosis. Endocrinology. 1998 Jul; 139(7):3232-40. Zapf-Colby A, Olefsky JM. PMID: 9645698.
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    230. Regulation of skeletal muscle hexokinase II by insulin in nondiabetic and NIDDM subjects. Diabetes. 1998 Jul; 47(7):1107-13. Kruszynska YT, Mulford MI, Baloga J, Yu JG, Olefsky JM. PMID: 9648835.
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    231. Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin. J Biol Chem. 1998 May 29; 273(22):13808-18. Kayali AG, Eichhorn J, Haruta T, Morris AJ, Nelson JG, Vollenweider P, Olefsky JM, Webster NJ. PMID: 9593725.
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    232. Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains. J Biol Chem. 1998 Mar 20; 273(12):6860-7. He W, Rose DW, Olefsky JM, Gustafson TA. PMID: 9506989.
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    233. Troglitazone prevents hyperglycemia-induced but not glucosamine-induced insulin resistance. Diabetes. 1998 Mar; 47(3):395-400. Miles PD, Higo K, Romeo OM, Lee MK, Rafaat K, Olefsky JM. PMID: 9519745.
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    234. Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1998 Feb 01; 128(3):176-85. Maggs DG, Buchanan TA, Burant CF, Cline G, Gumbiner B, Hsueh WA, Inzucchi S, Kelley D, Nolan J, Olefsky JM, Polonsky KS, Silver D, Valiquett TR, Shulman GI. PMID: 9454525.
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    235. Skeletal muscle peroxisome proliferator- activated receptor-gamma expression in obesity and non- insulin-dependent diabetes mellitus. J Clin Invest. 1998 Feb 01; 101(3):543-8. Kruszynska YT, Mukherjee R, Jow L, Dana S, Paterniti JR, Olefsky JM. PMID: 9449686; PMCID: PMC508596.
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    236. Ligand-independent GLUT4 translocation induced by guanosine 5'-O-(3-thiotriphosphate) involves tyrosine phosphorylation. Endocrinology. 1998 Jan; 139(1):358-64. Haruta T, Morris AJ, Vollenweider P, Nelson JG, Rose DW, Mueckler M, Olefsky JM. PMID: 9421434.
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    237. Mechanisms of insulin resistance in experimental hyperinsulinemic dogs. J Clin Invest. 1998 Jan 01; 101(1):202-11. Miles PD, Li S, Hart M, Romeo O, Cheng J, Cohen A, Raafat K, Moossa AR, Olefsky JM. PMID: 9421483; PMCID: PMC508557.
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    238. Adenovirus-mediated overexpression of IRS-1 interacting domains abolishes insulin-stimulated mitogenesis without affecting glucose transport in 3T3-L1 adipocytes. Mol Cell Biol. 1997 Dec; 17(12):7386-97. Sharma PM, Egawa K, Gustafson TA, Martin JL, Olefsky JM. PMID: 9372969; PMCID: PMC232594.
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    239. Evidence for decreased splanchnic glucose uptake after oral glucose administration in non-insulin-dependent diabetes mellitus. J Clin Invest. 1997 Nov 01; 100(9):2354-61. Ludvik B, Nolan JJ, Roberts A, Baloga J, Joyce M, Bell JM, Olefsky JM. PMID: 9410915; PMCID: PMC508433.
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    240. TNF-alpha-induced insulin resistance in vivo and its prevention by troglitazone. Diabetes. 1997 Nov; 46(11):1678-83. Miles PD, Romeo OM, Higo K, Cohen A, Rafaat K, Olefsky JM. PMID: 9356012.
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    241. The small guanosine triphosphate-binding protein Rab4 is involved in insulin-induced GLUT4 translocation and actin filament rearrangement in 3T3-L1 cells. Endocrinology. 1997 Nov; 138(11):4941-9. Vollenweider P, Martin SS, Haruta T, Morris AJ, Nelson JG, Cormont M, Le Marchand-Brustel Y, Rose DW, Olefsky JM. PMID: 9348225.
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    242. Effects of nonesterified fatty acids on glucose metabolism after glucose ingestion. Diabetes. 1997 Oct; 46(10):1586-93. Kruszynska YT, Mulford MI, Yu JG, Armstrong DA, Olefsky JM. PMID: 9313754.
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    243. The G12 coupled thrombin receptor stimulates mitogenesis through the Shc SH2 domain. Oncogene. 1997 Jul 31; 15(5):595-600. Collins LR, Ricketts WA, Olefsky JM, Brown JH. PMID: 9247313.
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    244. Mechanisms of the kinetic defect in insulin action in obesity and NIDDM. Diabetes. 1997 Jun; 46(6):994-1000. Nolan JJ, Ludvik B, Baloga J, Reichart D, Olefsky JM. PMID: 9166671.
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    245. Amylin release during oral glucose tolerance test. Diabet Med. 1997 Jun; 14 Suppl 2:S29-34. Thomaseth K, Pacini G, Clodi M, Kautzky-Willer A, Nolan JJ, Prager R, Olefsky JM, Ludvik B. PMID: 9212327.
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    246. Cellular insulin resistance in adipocytes from obese polycystic ovary syndrome subjects involves adenosine modulation of insulin sensitivity. J Clin Endocrinol Metab. 1997 May; 82(5):1421-5. Ciaraldi TP, Morales AJ, Hickman MG, Odom-Ford R, Olefsky JM, Yen SS. PMID: 9141527.
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    247. The proto-oncogene product p120(cbl) links c-Src and phosphatidylinositol 3'-kinase to the integrin signaling pathway. J Biol Chem. 1997 Feb 07; 272(6):3780-7. Ojaniemi M, Martin SS, Dolfi F, Olefsky JM, Vuori K. PMID: 9013636.
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    248. Thiazolidinediones in the treatment of insulin resistance and type II diabetes. Diabetes. 1996 Dec; 45(12):1661-9. Saltiel AR, Olefsky JM. PMID: 8922349.
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    249. Phosphatidylinositol 3-kinase is necessary and sufficient for insulin-stimulated stress fiber breakdown. Endocrinology. 1996 Nov; 137(11):5045-54. Martin SS, Rose DW, Saltiel AR, Klippel A, Williams LT, Olefsky JM. PMID: 8895379.
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    250. Functional roles of the Shc phosphotyrosine binding and Src homology 2 domains in insulin and epidermal growth factor signaling. J Biol Chem. 1996 Oct 18; 271(42):26165-9. Ricketts WA, Rose DW, Shoelson S, Olefsky JM. PMID: 8824262.
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    251. Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways. Endocrinology. 1996 Oct; 137(10):4427-34. Sasaoka T, Ishiki M, Sawa T, Ishihara H, Takata Y, Imamura T, Usui I, Olefsky JM, Kobayashi M. PMID: 8828504.
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    252. Cellular and molecular mechanisms of non-insulin dependent diabetes mellitus. J Investig Med. 1996 Oct; 44(8):413-28. Kruszynska YT, Olefsky JM. PMID: 8952222.
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    253. Protein tyrosine phosphatase 1B interacts with the activated insulin receptor. Diabetes. 1996 Oct; 45(10):1379-85. Seely BL, Staubs PA, Reichart DR, Berhanu P, Milarski KL, Saltiel AR, Kusari J, Olefsky JM. PMID: 8826975.
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    254. Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling. J Biol Chem. 1996 Sep 13; 271(37):22506-13. O'Neill TJ, Rose DW, Pillay TS, Hotta K, Olefsky JM, Gustafson TA. PMID: 8798417.
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    255. Effect of troglitazone on leptin production. Studies in vitro and in human subjects. Diabetes. 1996 Sep; 45(9):1276-8. Nolan JJ, Olefsky JM, Nyce MR, Considine RV, Caro JF. PMID: 8772734.
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    256. Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling. J Biol Chem. 1996 Aug 16; 271(33):19810-6. Kenner KA, Anyanwu E, Olefsky JM, Kusari J. PMID: 8702689.
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    257. Evidence for an insulin receptor substrate 1 independent insulin signaling pathway that mediates insulin-responsive glucose transporter (GLUT4) translocation. Proc Natl Acad Sci U S A. 1996 Aug 06; 93(16):8401-6. Morris AJ, Martin SS, Haruta T, Nelson JG, Vollenweider P, Gustafson TA, Mueckler M, Rose DW, Olefsky JM. PMID: 8710883; PMCID: PMC38683.
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    258. Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes. J Biol Chem. 1996 Jul 26; 271(30):17605-8. Martin SS, Haruta T, Morris AJ, Klippel A, Williams LT, Olefsky JM. PMID: 8663595.
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    259. Expression of dominant negative mutant SHPTP2 attenuates phosphatidylinositol 3'-kinase activity via modulation of phosphorylation of insulin receptor substrate-1. J Biol Chem. 1996 May 24; 271(21):12595-602. Ugi S, Maegawa H, Kashiwagi A, Adachi M, Olefsky JM, Kikkawa R. PMID: 8647870.
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    260. Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro. Diabetes. 1996 May; 45(5):699-701. Kolaczynski JW, Nyce MR, Considine RV, Boden G, Nolan JJ, Henry R, Mudaliar SR, Olefsky J, Caro JF. PMID: 8621027.
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    261. Involvement of ErbB2 in the signaling pathway leading to cell cycle progression from a truncated epidermal growth factor receptor lacking the C-terminal autophosphorylation sites. J Biol Chem. 1996 Apr 05; 271(14):8338-44. Sasaoka T, Langlois WJ, Bai F, Rose DW, Leitner JW, Decker SJ, Saltiel A, Gill GN, Kobayashi M, Draznin B, Olefsky JM. PMID: 8626530.
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    262. Glucose-induced phosphorylation of the insulin receptor. Functional effects and characterization of phosphorylation sites. J Clin Invest. 1996 Feb 01; 97(3):613-20. Pillay TS, Xiao S, Olefsky JM. PMID: 8609215; PMCID: PMC507096.
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    263. Insulin-stimulated GLUT4 translocation is mediated by a divergent intracellular signaling pathway. J Biol Chem. 1995 Nov 24; 270(47):27991-4. Haruta T, Morris AJ, Rose DW, Nelson JG, Mueckler M, Olefsky JM. PMID: 7499278.
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    264. Metabolic effects of troglitazone on fat-induced insulin resistance in the rat. Metabolism. 1995 Nov; 44(11):1489-94. Khoursheed M, Miles PD, Gao KM, Lee MK, Moossa AR, Olefsky JM. PMID: 7476339.
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    265. Negative feedback regulation and desensitization of insulin- and epidermal growth factor-stimulated p21ras activation. J Biol Chem. 1995 Oct 27; 270(43):25320-3. Langlois WJ, Sasaoka T, Saltiel AR, Olefsky JM. PMID: 7592690.
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    266. Acute effects of troglitazone on in vivo insulin action in normal rats. Metabolism. 1995 Sep; 44(9):1166-9. Lee MK, Olefsky JM. PMID: 7666790.
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    267. Effect of obesity on insulin resistance in normal subjects and patients with NIDDM. Diabetes. 1995 Sep; 44(9):1121-5. Ludvik B, Nolan JJ, Baloga J, Sacks D, Olefsky J. PMID: 7657038.
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    268. Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein. J Biol Chem. 1995 Aug 11; 270(32):19151-7. Seely BL, Reichart DR, Staubs PA, Jhun BH, Hsu D, Maegawa H, Milarski KL, Saltiel AR, Olefsky JM. PMID: 7642582.
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    269. Regulation of glucose transport in cultured muscle cells by novel hypoglycemic agents. Metabolism. 1995 Aug; 44(8):976-81. Ciaraldi TP, Huber-Knudsen K, Hickman M, Olefsky JM. PMID: 7637655.
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    270. Kinetics of insulin action in vivo. Identification of rate-limiting steps. Diabetes. 1995 Aug; 44(8):947-53. Miles PD, Levisetti M, Reichart D, Khoursheed M, Moossa AR, Olefsky JM. PMID: 7622001.
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    271. Mechanism of activation of guanine nucleotide exchange factor by insulin. Endocrine. 1995 Jul; 3(7):475-9. Langlois J, Leitner W, Medh J, Sasaoka T, Olefsky JM, Draznin B. PMID: 21153201.
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    272. Signal transduction pathways leading to insulin-induced early gene induction. Biochemistry. 1995 Jun 27; 34(25):7996-8004. Jhun BH, Haruta T, Meinkoth JL, Leitner W, Draznin B, Saltiel AR, Pang L, Sasaoka T, Olefsky JM. PMID: 7540866.
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    273. Insulin inhibits nuclear phosphatase activity: requirement for the C-terminal domain of the insulin receptor. Endocrinology. 1995 Jun; 136(6):2464-9. Reusch JE, Hsieh P, Bhuripanyo P, Carel K, Leitner JW, Olefsky JM, Draznin B. PMID: 7750468.
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    274. Weighing in on the lean genes. J Clin Invest. 1995 Jun; 95(6):2427-8. Olefsky JM. PMID: 7769085; PMCID: PMC295909.
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    275. Mechanisms of enhanced transmembrane signaling by an insulin receptor lacking a cytoplasmic beta-subunit domain. J Biol Chem. 1995 May 05; 270(18):10885-92. Sasaoka T, Langlois WJ, Rose DW, Olefsky JM. PMID: 7738028.
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    276. A noninvasive method to measure splanchnic glucose uptake after oral glucose administration. J Clin Invest. 1995 May; 95(5):2232-8. Ludvik B, Nolan JJ, Roberts A, Baloga J, Joyce M, Bell JM, Olefsky JM. PMID: 7738188; PMCID: PMC295835.
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    277. Functional characterization of hybrid receptors composed of a truncated insulin receptor and wild type insulin-like growth factor 1 or insulin receptors. Endocrinology. 1995 May; 136(5):1978-86. Langlois WJ, Sasaoka T, Yip CC, Olefsky JM. PMID: 7720646.
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    278. Insulin resistance and non-insulin-dependent diabetes mellitus: cellular and molecular mechanisms. Am J Clin Nutr. 1995 04; 61(4 Suppl):980S-986S. Olefsky JM, Nolan JJ. PMID: 7900697.
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    279. A functional assessment of insulin/insulin-like growth factor-I hybrid receptors. Endocrinology. 1995 Apr; 136(4):1635-41. Seely BL, Reichart DR, Takata Y, Yip C, Olefsky JM. PMID: 7895674.
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    280. Insulin stimulates the tyrosine dephosphorylation of pp125 focal adhesion kinase. J Biol Chem. 1995 Jan 20; 270(3):991-4. Pillay TS, Sasaoka T, Olefsky JM. PMID: 7836419.
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    281. The genetics of non-insulin-dependent diabetes mellitus. Adv Genet. 1995; 32:51-98. Pillay TS, Langlois WJ, Olefsky JM. PMID: 7741025.
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    282. The signaling pathway coupling epidermal growth factor receptors to activation of p21ras. J Biol Chem. 1994 Dec 23; 269(51):32621-5. Sasaoka T, Langlois WJ, Leitner JW, Draznin B, Olefsky JM. PMID: 7798267.
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    283. Insulin and epidermal growth factor influence guanine nucleotide-releasing factor by distinct mechanisms. Endocrinology. 1994 Dec; 135(6):2412-7. Langlois WJ, Medh J, Leitner JW, Sasaoka T, Olefsky JM, Draznin B. PMID: 7988425.
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    284. Metabolic effects of troglitazone on fructose-induced insulin resistance in the rat. Diabetes. 1994 Dec; 43(12):1435-9. Lee MK, Miles PD, Khoursheed M, Gao KM, Moossa AR, Olefsky JM. PMID: 7958495.
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    285. Localization of the insulin receptor binding sites for the SH2 domain proteins p85, Syp, and GAP. J Biol Chem. 1994 Nov 04; 269(44):27186-92. Staubs PA, Reichart DR, Saltiel AR, Milarski KL, Maegawa H, Berhanu P, Olefsky JM, Seely BL. PMID: 7525547.
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    286. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N Engl J Med. 1994 Nov 03; 331(18):1188-93. Nolan JJ, Ludvik B, Beerdsen P, Joyce M, Olefsky J. PMID: 7935656.
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    287. Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression. Mol Cell Biol. 1994 Nov; 14(11):7466-75. Jhun BH, Rose DW, Seely BL, Rameh L, Cantley L, Saltiel AR, Olefsky JM. PMID: 7935461; PMCID: PMC359282.
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    288. Islet amyloid polypeptide (amylin) increases the renal excretion of calcium in the conscious dog. Calcif Tissue Int. 1994 Oct; 55(4):269-73. Miles PD, Deftos LJ, Moossa AR, Olefsky JM. PMID: 7820778.
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    289. Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction. J Biol Chem. 1994 Aug 19; 269(33):21244-8. Xiao S, Rose DW, Sasaoka T, Maegawa H, Burke TR, Roller PP, Shoelson SE, Olefsky JM. PMID: 8063747.
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    290. Hybrid formation between endogenous mouse and transfected human tyrosine kinase-deficient (A/K1018) insulin receptors leads to decreased insulin sensitivity in 3T3-L1 adipocytes. Mol Endocrinol. 1994 Jun; 8(6):682-92. Grako KA, McClain DA, Olefsky JM. PMID: 7935484.
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    291. Comparison of the intracellular itineraries of insulin-like growth factor-I and insulin and their receptors in Rat-1 fibroblasts. Endocrinology. 1994 Jun; 134(6):2445-52. Zapf A, Hsu D, Olefsky JM. PMID: 8194471.
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    292. Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor. J Biol Chem. 1994 May 06; 269(18):13689-94. Sasaoka T, Rose DW, Jhun BH, Saltiel AR, Draznin B, Olefsky JM. PMID: 7513704.
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    293. Mutation of the two carboxyl-terminal tyrosines in the insulin receptor results in enhanced activation of mitogen-activated protein kinase. J Biol Chem. 1994 Apr 08; 269(14):10604-8. Pang L, Milarski KL, Ohmichi M, Takata Y, Olefsky JM, Saltiel AR. PMID: 8144649.
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    294. Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation. J Biol Chem. 1994 Apr 08; 269(14):10734-8. Sasaoka T, Draznin B, Leitner JW, Langlois WJ, Olefsky JM. PMID: 8144662.
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    295. Src homology 2 domains of protein tyrosine phosphatase are associated in vitro with both the insulin receptor and insulin receptor substrate-1 via different phosphotyrosine motifs. FEBS Lett. 1994 Mar 07; 340(3):216-20. Ugi S, Maegawa H, Olefsky JM, Shigeta Y, Kashiwagi A. PMID: 7510639.
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    296. Insulin and insulin-like growth factor-I signal transduction requires p21ras. J Biol Chem. 1994 Feb 25; 269(8):5699-704. Jhun BH, Meinkoth JL, Leitner JW, Draznin B, Olefsky JM. PMID: 8119907.
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    297. NPXY motif in the insulin-like growth factor-I receptor is required for efficient ligand-mediated receptor internalization and biological signaling. Endocrinology. 1994 Feb; 134(2):744-50. Hsu D, Knudson PE, Zapf A, Rolband GC, Olefsky JM. PMID: 8299569.
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    298. Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity. J Clin Endocrinol Metab. 1994 Feb; 78(2):471-7. Nolan JJ, Freidenberg G, Henry R, Reichart D, Olefsky JM. PMID: 8106637.
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    299. Mechanisms of cellular insulin resistance in human pregnancy. Am J Obstet Gynecol. 1994 Feb; 170(2):635-41. Ciaraldi TP, Kettel M, el-Roeiy A, Madar Z, Reichart D, Yen SS, Olefsky JM. PMID: 8116725.
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    300. Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction. Proc Natl Acad Sci U S A. 1994 Jan 18; 91(2):797-801. Rose DW, Saltiel AR, Majumdar M, Decker SJ, Olefsky JM. PMID: 8290602; PMCID: PMC43036.
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    301. Delayed onset of insulin activation of the insulin receptor kinase in vivo in human skeletal muscle. Diabetes. 1994 Jan; 43(1):118-26. Freidenberg GR, Suter S, Henry RR, Nolan J, Reichart D, Olefsky JM. PMID: 8262308.
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    302. Deletion of exon 21 of the insulin receptor eliminates tyrosine kinase activity but preserves mitogenic signaling. Biochemistry. 1993 Dec 14; 32(49):13545-50. Rolband GC, Williams JF, Webster NJ, Hsu D, Olefsky JM. PMID: 8257690.
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    303. Regulation of protein tyrosine phosphatases by insulin and insulin-like growth factor I. J Biol Chem. 1993 Dec 05; 268(34):25455-62. Kenner KA, Hill DE, Olefsky JM, Kusari J. PMID: 8244979.
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    304. Potential role for insulin and cycloheximide in regulating the intrinsic activity of glucose transporters in isolated rat adipocytes. Endocrinology. 1993 Dec; 133(6):2943-50. Karnieli E, Garvey WT, Olefsky JM, Hueckstead TP, Harel C, Maianu L, Armoni M. PMID: 8243322.
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    305. Insulin activates p21Ras and guanine nucleotide releasing factor in cells expressing wild type and mutant insulin receptors. J Biol Chem. 1993 Sep 25; 268(27):19998-20001. Draznin B, Chang L, Leitner JW, Takata Y, Olefsky JM. PMID: 8376360.
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    306. The insulin receptor C-terminus is involved in regulation of the receptor kinase activity. Biochemistry. 1993 Sep 21; 32(37):9539-44. Kaliman P, Baron V, Alengrin F, Takata Y, Webster NJ, Olefsky JM, Van Obberghen E. PMID: 7690586.
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    307. Deletion of the insulin receptor beta-subunit acidic domain results in enhanced metabolic signaling. Endocrinology. 1993 Sep; 133(3):1437-43. Rolband GC, Williams JF, Webster NJ, Olefsky JM. PMID: 8396020.
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    308. Effect of a major histocompatibility complex class I peptide on insulin-like growth factor-I receptor internalization and biological signaling. Endocrinology. 1993 Sep; 133(3):1247-51. Hsu D, Olefsky JM. PMID: 8365366.
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    309. Insulin-responsive human adipocytes express two glucose transporter isoforms and target them to different vesicles. J Clin Endocrinol Metab. 1993 Jul; 77(1):286-9. Pilch PF, Wilkinson W, Garvey WT, Ciaraldi TP, Hueckstaedt TP, Olefsky JM. PMID: 8325954.
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    310. Transmembrane signaling by an insulin receptor lacking a cytoplasmic beta-subunit domain. Proc Natl Acad Sci U S A. 1993 May 15; 90(10):4379-83. Sasaoka T, Takata Y, Kusari J, Anderson CM, Langlois WJ, Olefsky JM. PMID: 8506276; PMCID: PMC46514.
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    311. Relative expression of insulin receptor isoforms does not differ in lean, obese, and noninsulin-dependent diabetes mellitus subjects. J Clin Endocrinol Metab. 1993 May; 76(5):1380-2. Anderson CM, Henry RR, Knudson PE, Olefsky JM, Webster NJ. PMID: 7684396.
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    312. Mechanism of impaired metabolic signaling by a truncated human insulin receptor. Decreased activation of protein phosphatase 1 by insulin. J Biol Chem. 1993 Apr 15; 268(11):7917-22. Begum N, Olefsky JM, Draznin B. PMID: 8385127.
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    313. A truncated human insulin receptor missing the COOH-terminal 365 amino acid residues does not undergo insulin-mediated receptor migration or aggregation. Endocrinology. 1993 Apr; 132(4):1453-62. Smith RM, Sasaoka T, Shah N, Takata Y, Kusari J, Olefsky JM, Jarett L. PMID: 8462446.
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    314. Preparation of N epsilon B28-monoazidobenzoyl insulin-like growth factor I and photoaffinity labeling of insulin-like growth factor I receptor. Peptides. 1993 Mar-Apr; 14(2):325-30. Yip CC, Hsu H, Olefsky JM, Seely L. PMID: 8483809.
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    315. Insulin resistance and the pathogenesis of non-insulin dependent diabetes mellitus: cellular and molecular mechanisms. Adv Exp Med Biol. 1993; 334:129-50. Olefsky JM. PMID: 8249678.
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    316. Characterization of insulin-like growth factor (IGF) binding proteins and their role in modulating IGF-I action in BHK cells. J Biol Chem. 1992 Dec 15; 267(35):25576-82. Hsu D, Olefsky JM. PMID: 1281161.
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    317. Cellular mechanisms of insulin resistance in polycystic ovarian syndrome. J Clin Endocrinol Metab. 1992 Aug; 75(2):577-83. Ciaraldi TP, el-Roeiy A, Madar Z, Reichart D, Olefsky JM, Yen SS. PMID: 1322430.
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    318. Evidence that glucose transport is rate-limiting for in vivo glucose uptake. Metabolism. 1992 Aug; 41(8):897-902. Fink RI, Wallace P, Brechtel G, Olefsky JM. PMID: 1640870.
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    319. Tyrosine kinase-defective insulin receptors undergo decreased endocytosis but do not affect internalization of normal endogenous insulin receptors. Endocrinology. 1992 Jun; 130(6):3441-52. Grako KA, Olefsky JM, McClain DA. PMID: 1317784.
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    320. Intracellular signaling by a mutant human insulin receptor lacking the carboxyl-terminal tyrosine autophosphorylation sites. J Biol Chem. 1992 May 05; 267(13):9065-70. Takata Y, Webster NJ, Olefsky JM. PMID: 1577744.
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    321. Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects. Diabetes Care. 1992 Feb; 15(2):193-203. Suter SL, Nolan JJ, Wallace P, Gumbiner B, Olefsky JM. PMID: 1547676.
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    322. Phorbol ester-mediated protein kinase C interaction with wild-type and COOH-terminal truncated insulin receptors. J Biol Chem. 1991 Nov 15; 266(32):21760-4. Anderson CM, Olefsky JM. PMID: 1657981.
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    323. Contribution of postprandial insulin and glucose to glucose disposal in normal and insulin-resistant obese subjects. J Clin Endocrinol Metab. 1991 Oct; 73(4):758-64. Klauser R, Prager R, Schernthaner G, Olefsky JM. PMID: 1890150.
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    324. Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus. J Clin Invest. 1991 Oct; 88(4):1323-30. Kusari J, Verma US, Buse JB, Henry RR, Olefsky JM. PMID: 1918382; PMCID: PMC295602.
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    325. Tyrosine kinase-defective insulin receptors undergo insulin-induced microaggregation but do not concentrate in coated pits. J Biol Chem. 1991 Sep 15; 266(26):17522-30. Smith RM, Seely BL, Shah N, Olefsky JM, Jarett L. PMID: 1910046.
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    326. Lack of effect of islet amyloid polypeptide in causing insulin resistance in conscious dogs during euglycemic clamp studies. Diabetes. 1991 Aug; 40(8):998-1004. Kassir AA, Upadhyay AK, Lim TJ, Moossa AR, Olefsky JM. PMID: 1860564.
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    327. In vivo stimulation of the insulin receptor kinase in human skeletal muscle. Correlation with insulin-stimulated glucose disposal during euglycemic clamp studies. J Clin Invest. 1991 Jun; 87(6):2222-9. Freidenberg GR, Suter SL, Henry RR, Reichart D, Olefsky JM. PMID: 1645756; PMCID: PMC296983.
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    328. Mutation of the two carboxyl-terminal tyrosines results in an insulin receptor with normal metabolic signaling but enhanced mitogenic signaling properties. J Biol Chem. 1991 May 15; 266(14):9135-9. Takata Y, Webster NJ, Olefsky JM. PMID: 2026614.
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    329. Insulin action kinetics in adipocytes from obese and noninsulin-dependent diabetes mellitus subjects: identification of multiple cellular defects in glucose transport. J Clin Endocrinol Metab. 1991 Apr; 72(4):876-82. Ciaraldi TP, Molina JM, Olefsky JM. PMID: 2005215.
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    330. Insulin resistance and diabetes due to different mutations in the tyrosine kinase domain of both insulin receptor gene alleles. J Biol Chem. 1991 Mar 15; 266(8):5260-7. Kusari J, Takata Y, Hatada E, Freidenberg G, Kolterman O, Olefsky JM. PMID: 2002058.
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    331. Insulin-receptor cDNA sequence in NIDDM patient homozygous for insulin-receptor gene RFLP. Diabetes. 1991 Feb; 40(2):249-54. Kusari J, Olefsky JM, Strahl C, McClain DA. PMID: 1671379.
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    332. Transdominant inhibition of tyrosine kinase activity in mutant insulin/insulin-like growth factor I hybrid receptors. Proc Natl Acad Sci U S A. 1991 Jan 01; 88(1):214-8. Treadway JL, Morrison BD, Soos MA, Siddle K, Olefsky J, Ullrich A, McClain DA, Pessin JE. PMID: 1846039; PMCID: PMC50780.
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    333. In vitro studies on the action of CS-045, a new antidiabetic agent. Metabolism. 1990 Oct; 39(10):1056-62. Ciaraldi TP, Gilmore A, Olefsky JM, Goldberg M, Heidenreich KA. PMID: 2120548.
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    334. Defective insulin receptor function in down-regulated HepG2 cells. Endocrinology. 1990 Oct; 127(4):1706-17. Williams JF, Olefsky JM. PMID: 2169397.
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    335. The insulin receptor. A multifunctional protein. Diabetes. 1990 Sep; 39(9):1009-16. Olefsky JM. PMID: 2166696.
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    336. Kinetics of insulin-mediated and non-insulin-mediated glucose uptake in humans. Diabetes. 1990 Aug; 39(8):955-64. Edelman SV, Laakso M, Wallace P, Brechtel G, Olefsky JM, Baron AD. PMID: 1973673.
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    337. Kinetics of in vivo muscle insulin-mediated glucose uptake in human obesity. Diabetes. 1990 Aug; 39(8):965-74. Laakso M, Edelman SV, Olefsky JM, Brechtel G, Wallace P, Baron AD. PMID: 2197140.
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    338. The ligand binding characteristics of a kinase-defective A/K1018 human insulin receptor expressed in Rat 1 fibroblasts. Biochim Biophys Acta. 1990 Jul 12; 1053(2-3):185-8. Maegawa H, Kobayashi M, Egawa K, McClain DA, Olefsky JM, Shigeta Y. PMID: 2200525.
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    339. Characterization of an insulin receptor mutant lacking the subunit processing site. J Biol Chem. 1990 May 25; 265(15):8463-9. Williams JF, McClain DA, Dull TJ, Ullrich A, Olefsky JM. PMID: 2187866.
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    340. Insulin-receptor autophosphorylation and endogenous substrate phosphorylation in human adipocytes from control, obese, and NIDDM subjects. Diabetes. 1990 Feb; 39(2):250-9. Thies RS, Molina JM, Ciaraldi TP, Freidenberg GR, Olefsky JM. PMID: 2227134.
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    341. Induction of insulin resistance in vivo by amylin and calcitonin gene-related peptide. Diabetes. 1990 Feb; 39(2):260-5. Molina JM, Cooper GJ, Leighton B, Olefsky JM. PMID: 2227135.
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    342. Dissection of the growth versus metabolic effects of insulin and insulin-like growth factor-I in transfected cells expressing kinase-defective human insulin receptors. J Biol Chem. 1990 Jan 25; 265(3):1678-82. McClain DA, Maegawa H, Thies RS, Olefsky JM. PMID: 2153140.
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    343. Use of a variable tracer infusion method to determine glucose turnover in humans. Am J Physiol. 1990 Jan; 258(1 Pt 1):E16-23. Molina JM, Baron AD, Edelman SV, Brechtel G, Wallace P, Olefsky JM. PMID: 2405697.
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    344. Decreased activation rate of insulin-stimulated glucose transport in adipocytes from obese subjects. Diabetes. 1989 Aug; 38(8):991-5. Molina JM, Ciaraldi TP, Brady D, Olefsky JM. PMID: 2666204.
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    345. Effects of growth and insulin treatment on the levels of insulin receptors and their mRNA in Hep G2 cells. J Biol Chem. 1989 Apr 25; 264(12):6741-7. Hatada EN, McClain DA, Potter E, Ullrich A, Olefsky JM. PMID: 2540160.
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    346. Mechanism of defective insulin-receptor kinase activity in NIDDM. Evidence for two receptor populations. Diabetes. 1989 Mar; 38(3):397-403. Brillon DJ, Freidenberg GR, Henry RR, Olefsky JM. PMID: 2465197.
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    347. Cellular mechanisms of insulin resistance in non-insulin-dependent (type II) diabetes. Am J Med. 1988 Nov 28; 85(5A):86-105. Olefsky JM, Garvey WT, Henry RR, Brillon D, Matthaei S, Freidenberg GR. PMID: 3057897.
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    348. Functional and structural differences in human and rat-derived insulin receptors: characterization of the beta-subunit kinase activity. Endocrinology. 1988 Oct; 123(4):1837-47. Brillon DJ, Henry RR, Klein HH, Olefsky JM, Freidenberg GR. PMID: 2843349.
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    349. Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss. J Clin Invest. 1988 Oct; 82(4):1398-406. Freidenberg GR, Reichart D, Olefsky JM, Henry RR. PMID: 3170749; PMCID: PMC442697.
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    350. Insulin receptors with defective tyrosine kinase inhibit normal receptor function at the level of substrate phosphorylation. J Biol Chem. 1988 Sep 05; 263(25):12629-37. Maegawa H, Olefsky JM, Thies S, Boyd D, Ullrich A, McClain DA. PMID: 2970462.
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    351. Restriction-fragment-length polymorphism in insulin-receptor gene and insulin resistance in NIDDM. Diabetes. 1988 Aug; 37(8):1071-5. McClain DA, Henry RR, Ullrich A, Olefsky JM. PMID: 2899037.
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    352. Properties of a human insulin receptor with a COOH-terminal truncation. I. Insulin binding, autophosphorylation, and endocytosis. J Biol Chem. 1988 Jun 25; 263(18):8904-11. McClain DA, Maegawa H, Levy J, Huecksteadt T, Dull TJ, Lee J, Ullrich A, Olefsky JM. PMID: 2837467.
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    353. Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects. J Biol Chem. 1988 Jun 25; 263(18):8912-7. Maegawa H, McClain DA, Freidenberg G, Olefsky JM, Napier M, Lipari T, Dull TJ, Lee J, Ullrich A. PMID: 2837468.
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    354. Evidence for two independent pathways of insulin-receptor internalization in hepatocytes and hepatoma cells. Diabetes. 1988 Jun; 37(6):806-15. McClain DA, Olefsky JM. PMID: 2838354.
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    355. Intracellular insulin-receptor dissociation and segregation in a rat fibroblast cell line transfected with a human insulin receptor gene. J Biol Chem. 1988 May 05; 263(13):6101-8. Levy JR, Olefsky JM. PMID: 3283119.
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    356. Role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus. J Clin Invest. 1988 May; 81(5):1528-36. Garvey WT, Huecksteadt TP, Matthaei S, Olefsky JM. PMID: 3366906; PMCID: PMC442586.
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    357. Endocytotic uptake, processing, and retroendocytosis of human biosynthetic proinsulin by rat fibroblasts transfected with the human insulin receptor gene. J Clin Invest. 1988 May; 81(5):1370-7. Levy JR, Ullrich A, Olefsky JM. PMID: 3284910; PMCID: PMC442566.
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    358. Day-long integrated serum insulin and C-peptide profiles in patients with NIDDM. Correlation with urinary C-peptide excretion. Diabetes. 1988 May; 37(5):590-9. Garvey WT, Olefsky JM, Rubenstein AH, Kolterman OG. PMID: 3282946.
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    359. Cycloheximide decreases glucose transporters in rat adipocyte plasma membranes without affecting insulin-stimulated glucose transport. Biochem J. 1988 Apr 15; 251(2):491-7. Matthaei S, Olefsky JM, Karnieli E. PMID: 3041964; PMCID: PMC1149029.
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    360. Biochemical characterization and subcellular distribution of the glucose transporter from rat brain microvessels. Biochim Biophys Acta. 1987 Dec 11; 905(2):417-25. Matthaei S, Olefsky JM, Horuk R. PMID: 3318930.
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    361. The trafficking and processing of insulin and insulin receptors in cultured rat hepatocytes. Endocrinology. 1987 Dec; 121(6):2075-86. Levy JR, Olefsky JM. PMID: 3315635.
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    362. A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis. J Biol Chem. 1987 Oct 25; 262(30):14663-71. McClain DA, Maegawa H, Lee J, Dull TJ, Ulrich A, Olefsky JM. PMID: 3312193.
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    363. Insulin receptor kinase following internalization in isolated rat adipocytes. J Biol Chem. 1987 Aug 05; 262(22):10557-64. Klein HH, Freidenberg GR, Matthaei S, Olefsky JM. PMID: 3038888.
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    364. Adenosine modulates insulin activation of insulin receptor kinase in intact rat adipocytes. Endocrinology. 1987 Jun; 120(6):2339-45. Klein HH, Ciaraldi TP, Freidenberg GR, Olefsky JM. PMID: 3552635.
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    365. Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects. Diabetes. 1987 May; 36(5):607-11. Prager R, Wallace P, Olefsky JM. PMID: 3552793.
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    366. Non-insulin-mediated glucose uptake predominates in postabsorptive dogs. Am J Physiol. 1987 May; 252(5 Pt 1):E660-6. Lavelle-Jones M, Scott MH, Kolterman O, Moossa AR, Olefsky JM. PMID: 2883896.
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    367. In vivo regulation of non-insulin-mediated and insulin-mediated glucose uptake by epinephrine. J Clin Endocrinol Metab. 1987 May; 64(5):889-95. Baron AD, Wallace P, Olefsky JM. PMID: 2881942.
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    368. Nuclear translocation of the insulin receptor. A possible mediator of insulin's long term effects. J Biol Chem. 1987 Mar 05; 262(7):3362-8. Podlecki DA, Smith RM, Kao M, Tsai P, Huecksteadt T, Brandenburg D, Lasher RS, Jarett L, Olefsky JM. PMID: 3546306.
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    369. Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp. J Clin Invest. 1987 Mar; 79(3):790-800. Bergman RN, Prager R, Volund A, Olefsky JM. PMID: 3546379; PMCID: PMC424201.
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    370. Human adipocyte glucose transport system. Biochemical and functional heterogeneity of hexose carriers. J Clin Invest. 1987 Mar; 79(3):703-9. Matthaei S, Garvey WT, Horuk R, Hueckstaedt TP, Olefsky JM. PMID: 3102556; PMCID: PMC424180.
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    371. Hyperinsulinemia does not compensate for peripheral insulin resistance in obesity. Diabetes. 1987 Mar; 36(3):327-34. Prager R, Wallace P, Olefsky JM. PMID: 3542654.
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    372. The effects of biosynthetic human proinsulin on carbohydrate metabolism in non-insulin-dependent diabetes mellitus. N Engl J Med. 1987 Feb 19; 316(8):443-9. Glauber HS, Henry RR, Wallace P, Frank BH, Galloway JA, Cohen RM, Olefsky JM. PMID: 3543679.
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    373. Photolabeling of the adipocyte hexose carrier with an aryl azide derivative of maltose. Mol Cell Endocrinol. 1987 Feb; 49(2-3):181-8. May JM, Horuk R, Olefsky JM. PMID: 3556753.
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    374. The effect of insulin concentration on retroendocytosis in isolated rat adipocytes. Endocrinology. 1987 Feb; 120(2):450-6. Levy J, Olefsky JM. PMID: 3542501.
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    375. Selective suppression of hepatic glucose output by human proinsulin in the dog. Am J Physiol. 1987 Feb; 252(2 Pt 1):E230-6. Lavelle-Jones M, Scott MH, Kolterman O, Rubenstein AH, Olefsky JM, Moossa AR. PMID: 2881485.
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    376. Glucose and insulin co-regulate the glucose transport system in primary cultured adipocytes. A new mechanism of insulin resistance. J Biol Chem. 1987 Jan 05; 262(1):189-97. Garvey WT, Olefsky JM, Matthaei S, Marshall S. PMID: 3539929.
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    377. Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects. J Clin Invest. 1987 Jan; 79(1):240-50. Freidenberg GR, Henry RR, Klein HH, Reichart DR, Olefsky JM. PMID: 3540010; PMCID: PMC424032.
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    378. Adipocyte glycogen synthase and pyruvate dehydrogenase in obese and type II diabetic subjects. Am J Physiol. 1986 Oct; 251(4 Pt 1):E489-96. Mandarino LJ, Madar Z, Kolterman OG, Bell JM, Olefsky JM. PMID: 3094377.
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    379. Demonstration of insulin receptors and modulation of alkaline phosphatase activity by insulin in rat osteoblastic cells. Endocrinology. 1986 Oct; 119(4):1786-92. Levy JR, Murray E, Manolagas S, Olefsky JM. PMID: 3530724.
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    380. Blood-brain glucose transfer in diabetes mellitus. Decreased number of glucose transporters at blood-brain barrier. Diabetes. 1986 Oct; 35(10):1181-4. Matthaei S, Horuk R, Olefsky JM. PMID: 3530847.
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    381. Effects of weight loss on mechanisms of hyperglycemia in obese non-insulin-dependent diabetes mellitus. Diabetes. 1986 Sep; 35(9):990-8. Henry RR, Wallace P, Olefsky JM. PMID: 3527829.
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    382. Retroendocytosis of insulin in rat adipocytes. Endocrinology. 1986 Aug; 119(2):572-9. Levy JR, Olefsky JM. PMID: 3525121.
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    383. Effect of the alpha-glucosidase inhibitor Bay-O-1248 on the metabolic response of nondiabetic and diabetic rats to a high-carbohydrate diet. Am J Clin Nutr. 1986 Aug; 44(2):206-11. Madar Z, Olefsky J. PMID: 3728357.
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    384. In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects. J Clin Invest. 1986 Aug; 78(2):472-81. Prager R, Wallace P, Olefsky JM. PMID: 3525609; PMCID: PMC423584.
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    385. Recycling of photoaffinity-labeled insulin receptors in rat adipocytes. Dissociation of insulin-receptor complexes is not required for receptor recycling. J Biol Chem. 1986 Jul 05; 261(19):8655-9. Huecksteadt T, Olefsky JM, Brandenberg D, Heidenreich KA. PMID: 3522577.
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    386. Antiinsulin receptor antibodies in an insulin-dependent diabetic may arise as autoantiidiotypes. J Clin Endocrinol Metab. 1986 Jul; 63(1):56-61. Shoelson SE, Marshall S, Horikoshi H, Kolterman OG, Rubenstein AH, Olefsky JM. PMID: 3486878.
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    387. Effects of aging on glucose-mediated glucose disposal and glucose transport. J Clin Invest. 1986 Jun; 77(6):2034-41. Fink RI, Wallace P, Olefsky JM. PMID: 3519685; PMCID: PMC370565.
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    388. Insulin activation of insulin receptor tyrosine kinase in intact rat adipocytes. An in vitro system to measure histone kinase activity of insulin receptors activated in vivo. J Biol Chem. 1986 Apr 05; 261(10):4691-7. Klein HH, Freidenberg GR, Kladde M, Olefsky JM. PMID: 3007472.
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    389. The effects of proinsulin pretreatment on the combined actions of insulin and proinsulin in normal man. J Clin Endocrinol Metab. 1986 Apr; 62(4):785-8. Glauber HS, Wallace P, Galloway J, Frank BH, Olefsky JM. PMID: 3512594.
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    390. Increased phosphorylation of ribosomal protein S6 following microinjection of insulin receptor-kinase into Xenopus oocytes. Nature. 1986 Apr 3-9; 320(6061):459-61. Maller JL, Pike LJ, Freidenberg GR, Cordera R, Stith BJ, Olefsky JM, Krebs EG. PMID: 3083266.
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    391. Insulin induces progressive insulin resistance in cultured rat adipocytes. Sequential effects at receptor and multiple postreceptor sites. Diabetes. 1986 Mar; 35(3):258-67. Garvey WT, Olefsky JM, Marshall S. PMID: 3512337.
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    392. Kinetics of biosynthetic human proinsulin action in isolated rat adipocytes. Diabetes. 1986 Mar; 35(3):318-23. Ciaraldi TP, Brady D, Olefsky JM. PMID: 3512342.
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    393. Biochemical and functional heterogeneity of rat adipocyte glucose transporters. J Biol Chem. 1986 Feb 05; 261(4):1823-8. Horuk R, Matthaei S, Olefsky JM, Baly DL, Cushman SW, Simpson IA. PMID: 3511051.
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    394. Insulin internalization and degradation in adipocytes from normal and type II diabetic subjects. J Clin Endocrinol Metab. 1986 Feb; 62(2):268-74. Jochen AL, Berhanu P, Olefsky JM. PMID: 3510222.
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    395. Metabolic consequences of very-low-calorie diet therapy in obese non-insulin-dependent diabetic and nondiabetic subjects. Diabetes. 1986 Feb; 35(2):155-64. Henry RR, Wiest-Kent TA, Scheaffer L, Kolterman OG, Olefsky JM. PMID: 3510922.
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    396. Regulation of epidermal growth factor receptor number and phosphorylation by fasting in rat liver. J Biol Chem. 1986 Jan 15; 261(2):752-7. Freidenberg GR, Klein HH, Kladde MP, Cordera R, Olefsky JM. PMID: 3001081.
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    397. Glycemic effects of intensive caloric restriction and isocaloric refeeding in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1985 Nov; 61(5):917-25. Henry RR, Scheaffer L, Olefsky JM. PMID: 4044780.
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    398. Rates of noninsulin-mediated glucose uptake are elevated in type II diabetic subjects. J Clin Invest. 1985 Nov; 76(5):1782-8. Baron AD, Kolterman OG, Bell J, Mandarino LJ, Olefsky JM. PMID: 2865274; PMCID: PMC424207.
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    399. Insulin receptor kinase activity in rat liver. Regulation by fasting and high carbohydrate feeding. J Biol Chem. 1985 Oct 15; 260(23):12444-53. Freidenberg GR, Klein HH, Cordera R, Olefsky JM. PMID: 2995376.
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    400. Clinical, cellular, and physiologic effects of glyburide in non-insulin-dependent diabetes mellitus. Am J Med. 1985 Sep 20; 79(3B):109-12. Olefsky JM. PMID: 3931458.
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    401. Mechanisms of insulin resistance in non-insulin-dependent (type II) diabetes. Am J Med. 1985 Sep 20; 79(3B):12-22. Olefsky JM, Ciaraldi TP, Kolterman OG. PMID: 3901744.
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    402. Post-binding events in insulin action. Mol Cell Endocrinol. 1985 Aug; 42(1):1-20. Horuk R, Olefsky JM. PMID: 3896892.
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    403. Insulin receptor down-regulation is linked to an insulin-induced postreceptor defect in the glucose transport system in rat adipocytes. J Clin Invest. 1985 Jul; 76(1):22-30. Garvey WT, Olefsky JM, Marshall S. PMID: 3894420; PMCID: PMC423695.
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    404. The effect of insulin treatment on insulin secretion and insulin action in type II diabetes mellitus. Diabetes. 1985 Mar; 34(3):222-34. Garvey WT, Olefsky JM, Griffin J, Hamman RF, Kolterman OG. PMID: 3882489.
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    405. The metabolic clearance of insulin and the feedback inhibition of insulin secretion are altered with aging. Diabetes. 1985 Mar; 34(3):275-80. Fink RI, Revers RR, Kolterman OG, Olefsky JM. PMID: 3882495.
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    406. Modulation of insulin secretion by insulin and glucose in type II diabetes mellitus. J Clin Endocrinol Metab. 1985 Mar; 60(3):559-68. Garvey WT, Revers RR, Kolterman OG, Rubenstein AH, Olefsky JM. PMID: 3882736.
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    407. Substrate specificities of insulin and epidermal growth factor receptor kinases. Biochem Biophys Res Commun. 1985 Feb 28; 127(1):254-63. Klein HH, Freidenberg GR, Cordera R, Olefsky JM. PMID: 2983709.
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    408. The preparation and characterization of mono-iodinated photoreactive analogs of insulin. Biochem Biophys Res Commun. 1985 Feb 15; 126(3):1138-45. Heidenreich KA, Yip CC, Frank BH, Olefsky JM. PMID: 3884003.
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    409. Dissociation of insulin resistance and decreased insulin receptor binding in Duchenne muscular dystrophy. J Clin Endocrinol Metab. 1985 Feb; 60(2):320-7. Freidenberg GR, Olefsky JM. PMID: 3965491.
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    410. Insulin resistance in non-insulin dependent (type II) and insulin dependent (type I) diabetes mellitus. Adv Exp Med Biol. 1985; 189:176-205. Olefsky JM, Revers RR, Prince M, Henry RR, Garvey WT, Scarlett JA, Kolterman OG. PMID: 3898763.
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    411. Post binding events in insulin action. Diabetes Metab Rev. 1985; 1(1-2):59-97. Horuk R, Olefsky JM. PMID: 3915252.
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    412. Biosynthetic human insulin and proinsulin have additive but not synergistic effects on total body glucose disposal. J Clin Endocrinol Metab. 1984 Jun; 58(6):1094-8. Revers RR, Henry R, Schmeiser L, Kolterman O, Cohen R, Rubenstein A, Frank B, Galloway J, Olefsky JM. PMID: 6373809.
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    413. The metabolic effects of biosynthetic human proinsulin in individuals with type I diabetes. J Clin Endocrinol Metab. 1984 Jun; 58(6):973-9. Bergenstal RM, Cohen RM, Lever E, Polonsky K, Jaspan J, Blix PM, Revers R, Olefsky JM, Kolterman O, Steiner K, et al. PMID: 6373814.
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    414. Metabolism of photoaffinity-labeled insulin receptors by adipocytes. Role of internalization, degradation, and recycling. J Biol Chem. 1984 May 25; 259(10):6511-5. Heidenreich KA, Brandenburg D, Berhanu P, Olefsky JM. PMID: 6373760.
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    415. The impact of sulfonylurea treatment upon the mechanisms responsible for the insulin resistance in type II diabetes. Diabetes Care. 1984 May-Jun; 7 Suppl 1:81-8. Kolterman OG, Olefsky JM. PMID: 6376033.
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    416. The physiological significance of the glucose intolerance of aging. J Gerontol. 1984 May; 39(3):273-8. Fink RI, Kolterman OG, Olefsky JM. PMID: 6371116.
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    417. The acute and chronic effects of sulfonylurea therapy in type II diabetic subjects. Diabetes. 1984 Apr; 33(4):346-54. Kolterman OG, Gray RS, Shapiro G, Scarlett JA, Griffin J, Olefsky JM. PMID: 6423429.
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    418. The role of the glucose transport system in the postreceptor defect in insulin action associated with human aging. J Clin Endocrinol Metab. 1984 Apr; 58(4):721-5. Fink RI, Kolterman OG, Kao M, Olefsky JM. PMID: 6699133.
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    419. Influence of hyperglycemia on insulin's in vivo effects in type II diabetes. J Clin Invest. 1984 Mar; 73(3):664-72. Revers RR, Fink R, Griffin J, Olefsky JM, Kolterman OG. PMID: 6368585; PMCID: PMC425067.
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    420. Lack of in vivo insulin resistance in controlled insulin-dependent, type I, diabetic patients. J Clin Endocrinol Metab. 1984 Feb; 58(2):353-8. Revers RR, Kolterman OG, Scarlett JA, Gray RS, Olefsky JM. PMID: 6363437.
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    421. In vitro characterization of biosynthetic human proinsulin. Diabetes. 1984 Feb; 33(2):111-8. Podlecki DA, Frank BH, Olefsky JM. PMID: 6363165.
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    422. Insulin receptors in isolated human adipocytes. Characterization by photoaffinity labeling and evidence for internalization and cellular processing. J Clin Invest. 1983 Dec; 72(6):1958-70. Berhanu P, Kolterman OG, Baron A, Tsai P, Olefsky JM, Brandenburg D. PMID: 6358259; PMCID: PMC437036.
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    423. Characteristics of binding of a low affinity, noncooperative insulin [( LeuB25]insulin) to IM-9 lymphocytes. Endocrinology. 1983 Dec; 113(6):1963-71. Green A, Frank BH, Rubenstein A, Tager H, Olefsky JM. PMID: 6357764.
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    424. Length of acute exposure to insulin regulates the rate of deactivation of stimulated glucose transport in isolated rat adipocytes. Endocrinology. 1983 Nov; 113(5):1739-45. Ciaraldi TP, Olefsky JM. PMID: 6354696.
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    425. Separate intracellular pathways for insulin receptor recycling and insulin degradation in isolated rat adipocytes. J Cell Physiol. 1983 Nov; 117(2):195-203. Marshall S, Olefsky JM. PMID: 6355127.
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    426. Degradation of insulin receptors in rat adipocytes. Diabetes. 1983 Nov; 32(11):1001-9. Heidenreich KA, Berhanu P, Brandenburg D, Olefsky JM. PMID: 6357900.
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    427. Effect of temperature on coupling of insulin receptors to stimulation of glucose transport in isolated rat adipocytes. Metabolism. 1983 Oct; 32(10):1002-8. Ciaraldi TP, Olefsky JM. PMID: 6350807.
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    428. Characterization of the receptor binding properties of monoiodoinsulin isomers and the identification of different insulin receptor specificities in hepatic and extrahepatic tissues. Diabetes. 1983 Aug; 32(8):697-704. Podlecki DA, Frank BH, Kao M, Horikoshi H, Freidenberg G, Marshall S, Ciaraldi T, Olefsky JM. PMID: 6347766.
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    429. Structural differences between insulin receptors in the brain and peripheral target tissues. J Biol Chem. 1983 Jul 25; 258(14):8527-30. Heidenreich KA, Zahniser NR, Berhanu P, Brandenburg D, Olefsky JM. PMID: 6345543.
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    430. Food fallacies and blood sugar. N Engl J Med. 1983 Jul 07; 309(1):44-5. Crapo PA, Olefsky JM. PMID: 6855853.
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    431. Low pH accelerates dissociation of receptor-bound insulin. Endocrinology. 1983 Jul; 113(1):37-42. Marshall S, Podlecki DA, Olefsky JM. PMID: 6345144.
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    432. Insulin binding to erythrocytes incubated in vitro at physiological temperature. J Clin Endocrinol Metab. 1983 Jul; 57(1):107-14. Freidenberg GF, Kao M, Olefsky JM. PMID: 6343415.
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    433. Relationship between serum glucose level and the metabolic clearance rate of glucose in non-insulin-dependent diabetes mellitus. Diabetes. 1983 Jul; 32(7):627-32. Revers RR, Kolterman OG, Olefsky JM. PMID: 6345242.
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    434. Parallel decreases in the expression of receptors for insulin and insulin-like growth factor I in a mutant human fibroblast line. Diabetes. 1983 Jun; 32(6):541-4. Massague J, Freidenberg GF, Olefsky JM, Czech MP. PMID: 6313454.
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    435. Mechanisms of insulin resistance in aging. J Clin Invest. 1983 Jun; 71(6):1523-35. Fink RI, Kolterman OG, Griffin J, Olefsky JM. PMID: 6345584; PMCID: PMC370358.
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    436. Insulin treatment reverses the postreceptor defect in adipocyte 3-O-methylglucose transport in type II diabetes mellitus. J Clin Endocrinol Metab. 1983 Jun; 56(6):1195-201. Scarlett JA, Kolterman OG, Ciaraldi TP, Kao M, Olefsky JM. PMID: 6341390.
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    437. Insulin resistance in noninsulin-dependent diabetes mellitus: impact of sulfonylurea agents in vivo and in vitro. Am J Med. 1983 Jan 17; 74(1A):82-101. Kolterman OG, Prince MJ, Olefsky JM. PMID: 6401923.
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    438. Endocrine-metabolic relationships in patients with leprechaunism. J Natl Med Assoc. 1982 Dec; 74(12):1195-210. Elders MJ, Schedewie HK, Olefsky J, Givens B, Char F, Bier DM, Baldwin D, Fiser RH, Seyedabadi S, Rubenstein A. PMID: 7154104; PMCID: PMC2561419.
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    439. Insulin resistance in humans. Gastroenterology. 1982 Dec; 83(6):1313-8. Olefsky JM. PMID: 6751927.
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    440. Insulin-stimulated glucose transport in cultured fibroblasts from normal and noninsulin-dependent (type II) diabetic human subjects. J Clin Endocrinol Metab. 1982 Dec; 55(6):1226-30. Berhanu P, Tsai P, Olefsky JM. PMID: 6752171.
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    441. Role of glucose transport in the postreceptor defect of non-insulin-dependent diabetes mellitus. Diabetes. 1982 Nov; 31(11):1016-22. Ciaraldi TP, Kolterman OG, Scarlett JA, Kao M, Olefsky JM. PMID: 6757010.
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    442. In vivo deactivation of peripheral, hepatic, and pancreatic insulin action in man. Diabetes. 1982 Oct; 31(10):929-36. Gray RS, Scarlett JA, Griffin J, Olefsky JM, Kolterman OG. PMID: 6759226.
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    443. The effects of oral fructose, sucrose, and glucose in subjects with reactive hypoglycemia. Diabetes Care. 1982 Sep-Oct; 5(5):512-7. Crapo PA, Scarlett JA, Kolterman OG, Sanders LR, Hofeldt FD, Olefsky JM. PMID: 6765227.
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    444. Mechanisms of insulin degradation by isolated rat adipocytes. Mol Cell Biochem. 1982 Aug 20; 47(1):23-9. Olefsky JM, Saekow M. PMID: 6752691.
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    445. Surface binding and rates of internalization of 125I-insulin in adipocytes and IM-9 lymphocytes. J Biol Chem. 1982 Aug 10; 257(15):8667-73. Olefsky JM, Kao M. PMID: 7047524.
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    446. Internalization and degradation of a low affinity insulin ([LeuB24]insulin) by rat adipocytes. FEBS Lett. 1982 Aug 02; 144(2):255-8. Green A, Tager H, Rubenstein A, Frank B, Olefsky JM. PMID: 6749549.
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    447. Kinetic relationships between insulin receptor binding and effects on glucose transport in isolated rat adipocytes. Biochemistry. 1982 Jul 06; 21(14):3475-80. Ciaraldi TP, Olefsky JM. PMID: 7052124.
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    448. Internalization and intracellular processing of insulin and insulin receptors in adipocytes. Metabolism. 1982 Jul; 31(7):670-90. Olefsky JM, Marshall S, Berhanu P, Saekow M, Heidenreich K, Green A. PMID: 7045573.
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    449. Insulin treatment reverses the insulin resistance of type II diabetes mellitus. Diabetes Care. 1982 Jul-Aug; 5(4):353-63. Scarlett JA, Gray RS, Griffin J, Olefsky JM, Kolterman OG. PMID: 6759075.
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    450. Insulin resistance in non-insulin-dependent, type II diabetes mellitus. Clin Endocrinol Metab. 1982 Jul; 11(2):363-88. Kolterman OG, Scarlett JA, Olefsky JM. PMID: 6754161.
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    451. Internalization and molecular processing of insulin receptors in isolated rat adipocytes. Proc Natl Acad Sci U S A. 1982 Jul; 79(13):4069-73. Berhanu P, Olefsky JM, Tsai P, Thamm P, Saunders D, Brandenburg D. PMID: 7051001; PMCID: PMC346578.
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    452. Insulin resistance and diabetes due to a genetic defect in insulin receptors. J Clin Endocrinol Metab. 1982 Jul; 55(1):123-31. Scarlett JA, Kolterman OG, Moore P, Saekow M, Insel J, Griffin J, Mako M, Rubenstein AH, Olefsky JM. PMID: 7042734.
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    453. Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus. Am J Physiol. 1982 Jul; 243(1):E15-30. Olefsky JM, Kolterman OG, Scarlett JA. PMID: 7046470.
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    454. Photoaffinity labeling of insulin receptors in viable cultured human lymphocytes. Demonstration of receptor shedding and degradation. Diabetes. 1982 May; 31(5 Pt 1):410-7. Berhanu P, Olefsky JM. PMID: 7152133.
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    455. Comparison of the effects of insulin and H2O2 on adipocyte glucose transport. J Cell Physiol. 1982 Mar; 110(3):323-8. Ciaraldi TP, Olefsky JM. PMID: 7045141.
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    456. Potentiation of insulin binding and insulin action by purified porcine relaxin. Ann N Y Acad Sci. 1982; 380:200-16. Olefsky JM, Saekow M, Kroc RL. PMID: 7044233.
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    457. Effect of a glucosidase inhibitor on the metabolic response of diabetic rats to a high carbohydrate diet, consisting of starch and sucrose, or glucose. Metabolism. 1982 Jan; 31(1):88-92. Gray RS, Olefsky JM. PMID: 7043164.
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    458. Hepatic ultrastructure in leprechaunism. Hepatic ultrastructural evidence suggesting a syndrome with defective hepatic glucose release. Virchows Arch A Pathol Anat Histol. 1982; 397(2):121-30. Roth SI, Schedewie HK, Bier DM, Conaway HH, Olefsky J, Rubenstein A, Elders MJ. PMID: 7179734.
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    459. Evidence for insulin-induced internalization and degradation of insulin receptors in rat adipocytes. Proc Natl Acad Sci U S A. 1982 Jan; 79(2):427-31. Green A, Olefsky JM. PMID: 7043460; PMCID: PMC345756.
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    460. Evidence for recycling of insulin receptors in isolated rat adipocytes. J Biol Chem. 1981 Nov 25; 256(22):11464-70. Marshall S, Green A, Olefsky JM. PMID: 7028734.
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    461. Regulation of insulin receptors in cultured human fibroblasts. Endocrinology. 1981 Nov; 109(5):1754-9. Prince MJ, Baldwin D, Tsai P, Olefsky JM. PMID: 7297502.
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    462. Simultaneous inhibition of insulin and somatomedin-C binding to cultured IM-9 lymphocytes by naturally occurring antireceptor antibodies. Diabetes. 1981 Nov; 30(11):979-82. Rosenfeld RG, Baldwin D, Dollar LA, Hintz RL, Olefsky JM, Rubenstein A. PMID: 6271619.
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    463. Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus. J Clin Invest. 1981 Oct; 68(4):957-69. Kolterman OG, Gray RS, Griffin J, Burstein P, Insel J, Scarlett JA, Olefsky JM. PMID: 7287908; PMCID: PMC370882.
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    464. Mechanism of the postreceptor defect in insulin action in human obesity. Decrease in glucose transport system activity. J Clin Invest. 1981 Oct; 68(4):875-80. Ciaraldi TP, Kolterman OG, Olefsky JM. PMID: 7026616; PMCID: PMC370874.
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    465. Tris (hydroxmethyl) aminomethane permits the expression of insulin-induced receptor loss in isolated rat adipocytes. Biochem Biophys Res Commun. 1981 Sep 30; 102(2):646-53. Marshall S, Olefsky JM. PMID: 7030343.
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    466. Characterization of insulin-induced receptor loss and evidence for internalization of the insulin receptor. Diabetes. 1981 Sep; 30(9):746-53. Marshall S, Olefsky JM. PMID: 7021273.
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    467. Insulin binding, internalization, and receptor regulation in cultured human fibroblasts. Am J Physiol. 1981 Sep; 241(3):E251-60. Baldwin D, Prince M, Tsai P, Johnson C, Lotan R, Rubenstein AH, Olefsky JM. PMID: 7025657.
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    468. Cutaneous manifestations of leprechaunism. Arch Dermatol. 1981 Sep; 117(9):531-5. Roth SI, Schedewie HK, Herzberg VK, Olefsky J, Elders MJ, Rubenstein A. PMID: 7294844.
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    469. Effects of prednisolone and dexamethasone in vivo and in vitro: studies of insulin binding, deoxyglucose uptake and glucose oxidation in rat adipocytes. Diabetologia. 1981 Aug; 21(2):149-53. De Pirro R, Green A, Kao MY, Olefsky JM. PMID: 7021286.
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    470. Relationship between negative cooperativity and insulin action. Biochemistry. 1981 Jul 21; 20(15):4488-92. Olefsky JM, Green A, Ciaraldi TP, Saekow M, Rubenstein AH, Tager HS. PMID: 7025901.
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    471. Insulin binding, internalization, and insulin receptor regulation in fibroblasts from type II, non-insulin-dependent diabetic subjects. Diabetes. 1981 Jul; 30(7):596-600. Prince MJ, Tsai P, Olefsky JM. PMID: 7018965.
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    472. Effects of insulin and insulin-like agents on the glucose transport system of cultured human fibroblasts. Diabetes. 1981 Jun; 30(6):523-9. Berhanu P, Olefsky JM. PMID: 7014316.
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    473. Metabolic requirements for deactivation of insulin-stimulated glucose transport in isolated rat adipocytes. Arch Biochem Biophys. 1981 May; 208(2):502-7. Ciaraldi TP, Olefsky JM. PMID: 7020602.
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    474. Insulin binding in human pregnancy: comparisons to the postpartum, luteal, and follicular states. J Clin Endocrinol Metab. 1981 May; 52(5):937-41. Moore P, Kolterman O, Weyant J, Olefsky JM. PMID: 7014589.
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    475. Hormonal and substrate responses to a standard meal in normal and hypertriglyceridemic subjects. Metabolism. 1981 Apr; 30(4):331-4. Crapo PA, Reaven GM, Olefsky JM. PMID: 7010076.
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    476. Insulin binding, biologic activity, and metabolism of biosynthetic human insulin. Diabetes Care. 1981 Mar-Apr; 4(2):244-7. Olefsky JM. PMID: 7011736.
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    477. LIlly lecture 1980. Insulin resistance and insulin action. An in vitro and in vivo perspective. Diabetes. 1981 Feb; 30(2):148-62. Olefsky JM. PMID: 7009267.
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    478. Mechanisms of insulin resistance in obesity and noninsulin-dependent (type II) diabetes. Am J Med. 1981 Jan; 70(1):151-68. Olefsky JM, Kolterman OG. PMID: 7006388.
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    479. The endocytotic-internalization pathway of insulin metabolism: relationship to insulin degradation and activation of glucose transport. Endocrinology. 1980 Dec; 107(6):1937-45. Marshall S, Olefsky JM. PMID: 7000505.
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    480. Effect of a high carbohydrate diet on adipocyte glucose metabolism in spontaneously obese rats and insulin-deficient diabetic rats. Endocrinology. 1980 Dec; 107(6):2004-10. Saekow M, Olefsky JM. PMID: 7428703.
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    481. Glucose kinetics in leprechaunism: accelerated fasting due to insulin resistance. J Clin Endocrinol Metab. 1980 Nov; 51(5):988-94. Bier DM, Schedewie H, Larner J, Olefsky J, Rubenstein A, Fiser RH, Craig JW, Elders MJ. PMID: 6999010.
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    482. Effects of insulin incubation on insulin binding, glucose transport, and insulin degradation by isolated rat adipocytes. Evidence for hormone-induced desensitization at the receptor and postreceptor level. J Clin Invest. 1980 Oct; 66(4):763-72. Marshall S, Olefsky JM. PMID: 6999035; PMCID: PMC371651.
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    483. Regulation of insulin receptors: evidence for involvement of an endocytotic internalization pathway. Proc Natl Acad Sci U S A. 1980 Oct; 77(10):5975-8. Baldwin D, Prince M, Marshall S, Davies P, Olefsky JM. PMID: 6108561; PMCID: PMC350195.
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    484. Direct in vitro effect of a sulfonylurea to increase human fibroblast insulin receptors. J Clin Invest. 1980 Sep; 66(3):608-11. Prince MJ, Olefsky JM. PMID: 6772676; PMCID: PMC371691.
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    485. A defect in cell-mediated immune function in insulin-resistant diabetic and obese subjects. J Lab Clin Med. 1980 Sep; 96(3):535-43. Kolterman OG, Olefsky JM, Kurahara C, Taylor K. PMID: 6995542.
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    486. Effects of oral fructose in normal, diabetic, and impaired glucose tolerance subjects. Diabetes Care. 1980 Sep-Oct; 3(5):575-82. Crapo PA, Kolterman OG, Olefsky JM. PMID: 7002511.
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    487. Postprandial hormonal responses to different types of complex carbohydrate in individuals with impaired glucose tolerance. Am J Clin Nutr. 1980 Aug; 33(8):1723-8. Crapo PA, Kolterman OG, Waldeck N, Reaven GM, Olefsky JM. PMID: 6996472.
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    488. Characterization of a mutant human insulin species. J Biol Chem. 1980 Jul 10; 255(13):6098-105. Olefsky JM, Saekow M, Tager H, Rubenstein AH. PMID: 6993466.
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    489. Semisynthesis and biological activity of porcine [LeuB24]insulin and [LeuB25]insulin. Proc Natl Acad Sci U S A. 1980 Jun; 77(6):3181-5. Tager H, Thomas N, Assoian R, Rubenstein A, Saekow M, Olefsky J, Kaiser ET. PMID: 6997872; PMCID: PMC349578.
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    490. Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects. J Clin Invest. 1980 Jun; 65(6):1272-84. Kolterman OG, Insel J, Saekow M, Olefsky JM. PMID: 6997333; PMCID: PMC371464.
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    491. Mechanism of hypertriglyceridaemia in diabetic patients with fasting hyperglycaemia. Diabetologia. 1980 Jun; 18(6):441-6. Greenfield M, Kolterman O, Olefsky J, Reaven GM. PMID: 7418956.
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    492. Role of intracellular energy in insulin's ability to activate 3-O-methylglucose transport by rat adipocytes. Biochemistry. 1980 May 13; 19(10):2183-90. Siegel J, Olefsky JM. PMID: 6990973.
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    493. Fructose, xylitol, and sorbitol. Diabetes Care. 1980 Mar-Apr; 3(2):390-3. Olefsky JM, Crapo P. PMID: 7389552.
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    494. Short-term regulation of insulin receptor affinity in man. Diabetes. 1980 Feb; 29(2):132-9. Insel JR, Kolterman OG, Saekow M, Olefsky JM. PMID: 6986298.
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    495. Relationship between deactivation of insulin-stimulated glucose transport and insulin dissociation in isolated rat adipocytes. J Biol Chem. 1980 Jan 25; 255(2):327-30. Ciaraldi TP, Olefsky JM. PMID: 7356614.
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    496. Diabetes due to secretion of an abnormal insulin. N Engl J Med. 1980 Jan 17; 302(3):129-35. Given BD, Mako ME, Tager HS, Baldwin D, Markese J, Rubenstein AH, Olefsky J, Kobayashi M, Kolterman O, Poucher R. PMID: 7350438.
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    497. Pancreas. Clin Endocrinol Metab. 1979 Nov; 8(3):579-601. Olefsky JM, Kolterman OG. PMID: 389492.
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    498. Effects of lysosomotropic agents on insulin interactions with adipocytes. Evidence for a lysosomal pathway for insulin processing and degradation. J Biol Chem. 1979 Oct 25; 254(20):10153-60. Marshall S, Olefsky JM. PMID: 489589.
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    499. A structurally abnormal insulin causing human diabetes. Nature. 1979 Sep 13; 281(5727):122-5. Tager H, Given B, Baldwin D, Mako M, Markese J, Rubenstein A, Olefsky J, Kobayashi M, Kolterman O, Poucher R. PMID: 381941.
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    500. Effect of a high carbohydrate diet on insulin binding to adipocytes and on insulin action in vivo in man. Diabetes. 1979 Aug; 28(8):731-6. Kolterman OG, Greenfield M, Reaven GM, Saekow M, Olefsky JM. PMID: 446930.
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    501. Effect of experimental hyperinsulinaemia on intracellular glucose metabolism of isolated adipocytes. Diabetologia. 1979 Aug; 17(2):111-6. Kobayashi M, Olefsky JM. PMID: 488566.
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    502. Insulin-stimulated glucose transport in human adipocytes. Am J Physiol. 1979 Jun; 236(6):E621-5. Ciaraldi TP, Kolterman OG, Siegel JA, Olefsky JM. PMID: 443417.
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    503. The effects of acute and chronic starvation on insulin binding to isolated human adipocytes. J Clin Endocrinol Metab. 1979 May; 48(5):836-42. Kolterman OG, Saekow M, Olefsky JM. PMID: 429529.
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    504. Interactions between insulin and its receptors after the initial binding event. Functional heterogeneity and relationships to insulin degradation. Diabetes. 1979 May; 28(5):460-71. Olefsky JM, Kobayashi M, Chang H. PMID: 437375.
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    505. Comparison of the effects of insulin and insulin-like agents on different aspects of adipocyte metabolism. Horm Metab Res. 1979 Mar; 11(3):209-13. Olefsky JM. PMID: 447201.
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    506. Coupling of insulin receptors to glucose transport: a temperature-dependent time lag in activation of glucose transport. Arch Biochem Biophys. 1979 Mar; 193(1):221-31. Ciaraldi TP, Olefsky JM. PMID: 453850.
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    507. Relationship between in vivo insulin resistance and decreased insulin receptors in obese man. J Clin Endocrinol Metab. 1979 Mar; 48(3):487-94. Kolterman OG, Reaven GM, Olefsky JM. PMID: 429500.
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    508. Further evidence for functional heterogeneity of adipocyte insulin receptors. Endocrinology. 1979 Feb; 104(2):462-6. Olefsky JM, Chang H. PMID: 446370.
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    509. Effects of streptozotocin-induced diabetes on insulin binding, glucose transport, and intracellular glucose metabolism in isolated rat adipocytes. Diabetes. 1979 Feb; 28(2):87-95. Kobayashi M, Olefsky JM. PMID: 154427.
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    510. Defect in glucose removal in nonketotic diabetic patients with fasting hyperglycemia. Diabetes. 1979 Jan; 28(1):32-4. Davis BM, Bernstein R, Kolterman O, Olefsky JM, Reaven GM. PMID: 569610.
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    511. The effects of dietary carbohydrate content on insulin binding and glucose metabolism by isolated rat adipocytes. Endocrinology. 1978 Dec; 103(6):2252-63. Olefsky JM, Saekow M. PMID: 748046.
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    512. Ability of circulating insulin to chronically regulate the cellular glucose transport system. Metabolism. 1978 Dec; 27(12 Suppl 2):1917-29. Olefsky JM, Kobayashi M. PMID: 723641.
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    513. The effect of ten days of fasting on various aspects of carbohydrate metabolism in obese diabetic subjects with significant fasting hyperglycemia. Metabolism. 1978 Dec; 27(12 Suppl 2):1839-52. Greenfield M, Kolterman O, Olefsky JM, Reaven GM. PMID: 723636.
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    514. Insulin binding to adipocytes. Evidence for functionally distinct receptors. Diabetes. 1978 Sep; 27(9):946-58. Olefsky JM, Chang H. PMID: 689306.
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    515. Effect of experimental hyperinsulinemia on insulin binding and glucose transport in isolated rat adipocytes. Am J Physiol. 1978 Jul; 235(1):E53-62. Kobayashi M, Olefsky JM. PMID: 677310.
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    516. Long-term regulation of adipocyte glucose transport capacity by circulating insulin in rats. J Clin Invest. 1978 Jul; 62(1):73-81. Kobayashi M, Olefsky JM. PMID: 659640; PMCID: PMC371738.
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    517. Insulin resistance due to a defect distal to the insulin receptor: demonstration in a patient with leprechaunism. Proc Natl Acad Sci U S A. 1978 Jul; 75(7):3469-73. Kobayashi M, Olefsky JM, Elders J, Mako ME, Given BD, Schedwie HK, Fiser RH, Hintz RL, Horner JA, Rubenstein AH. PMID: 277948; PMCID: PMC392799.
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    518. Mechanisms of the ability of insulin to activate the glucose-transport system in rat adipocytes. Biochem J. 1978 Apr 15; 172(1):137-45. Olefsky JM. PMID: 656068; PMCID: PMC1185672.
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    519. Hepatic insulin responsiveness in patients with endogenous hypertriglyceridaemia. Diabetologia. 1978 Apr; 14(4):249-53. Bernstein RM, Davis BM, Olefsky JM, Reaven GM. PMID: 205476.
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    520. Mechanisms of fasting-induced increase in insulin binding to rat adipocytes. J Clin Invest. 1978 Feb; 61(2):329-38. Olefsky JM, Kobayashi M. PMID: 621276; PMCID: PMC372543.
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    521. The role of insulin resistance in the pathogenesis of diabetes mellitus. Adv Metab Disord. 1978; 9:313-31. Reaven GM, Olefsky JM. PMID: 417568.
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    522. Postprandial plasma-glucose and -insulin responses to different complex carbohydrates. Diabetes. 1977 Dec; 26(12):1178-83. Crapo PA, Reaven G, Olefsky J. PMID: 590639.
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    523. Factitious hypoglycemia. Diagnosis by measurement of serum C-peptide immunoreactivity and insulin-binding antibodies. N Engl J Med. 1977 Nov 10; 297(19):1029-32. Scarlett JA, Mako ME, Rubenstein AH, Blix PM, Goldman J, Horwitz DL, Tager H, Jaspan JB, Stjernholm MR, Olefsky JM. PMID: 198659.
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    524. Does glucagon play a role in the insulin resistance of patients with adult non-ketotic diabetes? Diabetologia. 1977 Aug; 13(4):327-30. Olefsky JM, Sperling MA, Reaven GM. PMID: 913924.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    525. Insensitivity of large rat adipocytes to the antilipolytic effects of insulin. J Lipid Res. 1977 Jul; 18(4):459-64. Olefsky JM. PMID: 894138.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    526. Insulin binding in diabetes. Relationships with plasma insulin levels and insulin sensitivity. Diabetes. 1977 Jul; 26(7):680-8. Olefsky JM, Reaven GM. PMID: 873075.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    527. Relationship between heterogeneity of insulin responses and insulin resistance in normal subjects and patients with chemical diabetes. Diabetologia. 1977 May; 13(3):201-6. Reaven GM, Olefsky JM. PMID: 873087.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    528. Mechanisms of decreased insulin responsiveness of large adipocytes. Endocrinology. 1977 Apr; 100(4):1169-77. Olefsky JM. PMID: 837879.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    529. Interaction between insulin receptors and glucose transport: effect of prostaglandin E2. Biochem Biophys Res Commun. 1977 Mar 21; 75(2):271-6. Olefsky JM. PMID: 851438.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    530. Effects of fasting on insulin binding, glucose transport, and glucose oxidation in isolated rat adipocytes: relationships between insulin receptors and insulin action. J Clin Invest. 1976 Dec; 58(6):1450-60. Olefsky JM. PMID: 993354; PMCID: PMC333317.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    531. The insulin receptor: its role in insulin resistance of obesity and diabetes. Diabetes. 1976 Dec; 25(12):1154-62. Olefsky JM. PMID: 791735.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    532. Plasma glucose and insulin responses to orally administered simple and complex carbohydrates. Diabetes. 1976 Sep; 25(9):741-7. Crapo PA, Reaven G, Olefsky J. PMID: 955301.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    533. Locating the site(s) of insulin resistance in patients with nonketotic diabetes mellitus. Diabetes. 1976 Aug; 25(8):673-8. Kimmerling G, Javorski C, Olefsky JM, Reaven GM. PMID: 955298.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    534. Insulin's effect on glucose oxidation independent of glucose transport. Biochem Biophys Res Commun. 1976 Jul 12; 71(1):106-13. Olefsky JM. PMID: 962906.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    535. Insulin binding to monocytes and total mononuclear leukocytes from normal and diabetic patients. J Clin Endocrinol Metab. 1976 Jul; 43(1):226-31. Olefsky JM, Reaven GM. PMID: 947940.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    536. Postprandial plasma triglyceride and cholesterol responses to a low-fat meal. Am J Clin Nutr. 1976 May; 29(5):535-9. Olefsky JM, Crapo P, Reaven GM. PMID: 178167.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    537. Decreased insulin binding to adipocytes and circulating monocytes from obese subjects. J Clin Invest. 1976 May; 57(5):1165-72. Olefsky JM. PMID: 177453; PMCID: PMC436769.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    538. Induction of hypertriglyceridemia by a low-fat diet. J Clin Endocrinol Metab. 1976 Apr; 42(4):729-35. Ginsberg H, Olefsky JM, Kimmerling G, Crapo P, Reaven GM. PMID: 1262445.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    539. The effects of spontaneous obesity on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes. J Clin Invest. 1976 Apr; 57(4):842-51. Olefsky JM. PMID: 181402; PMCID: PMC436727.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    540. Effects of glucocorticoids on carbohydrate metabolism. Am J Med Sci. 1976 Mar-Apr; 271(2):202-10. Olefsky JM, Kimmerling G. PMID: 178180.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    541. Insulin receptors of skeletal muscle: specific insulin binding sites and demonstration of decreased numbers of sites in obese rats. Metabolism. 1976 Feb; 25(2):179-91. Olefsky J, Bacon VC, Baur S. PMID: 2834.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    542. Effects of sulfonylurea therapy on insulin binding to mononuclear leukocytes of diabetic patients. Am J Med. 1976 Jan; 60(1):89-95. Olefsky JM, Reaven GM. PMID: 175653.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    543. Nonketotic diabetes mellitus: insulin deficiency or insulin resistance? Am J Med. 1976 Jan; 60(1):80-8. Reaven GM, Bernstein R, Davis B, Olefsky JM. PMID: 814810.
      View in: PubMed   Mentions: 62     Fields:    Translation:Humans
    544. Effect of dexamethasone on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes. J Clin Invest. 1975 Dec; 56(6):1499-1508. Olefsky JM. PMID: 1202081; PMCID: PMC333128.
      View in: PubMed   Mentions: 54     Fields:    Translation:Animals
    545. Comparison of 125-I-insulin binding and degradation to isolated rat hepatocytes and liver membranes. Diabetes. 1975 Sep; 24(9):801-10. Olefsky J, Johnson J, Liu F, Edwards P, Baur S. PMID: 169175.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    546. Effects of age and obesity on insulin binding to isolated adipocytes. Endocrinology. 1975 Jun; 96(6):1486-98. Olefsky JM, Reaven GM. PMID: 165063.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    547. Quantification of plasma cholesterol and triglyceride levels in hypercholesterolemic subjects receiving ascorbic acid supplements. Am J Clin Nutr. 1975 Jun; 28(6):584-7. Peterson VE, Crapo PA, Weininger J, Ginsberg H, Olefsky J. PMID: 165703.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    548. Metabolic effects of increased caloric intake in man. Metabolism. 1975 Apr; 24(4):495-503. Olefsky J, Crapo PA, Ginsberg H, Reaven GM. PMID: 1117841.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    549. The effects of acute and chronic dexamethasone administration on insulin binding to isolated rat hepatocytes and adipocytes. Metabolism. 1975 Apr; 24(4):517-27. Olefsky JM, Johnson J, Liu F, Jen P, Reaven GM. PMID: 1117842.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    550. Evaluation of insulin resistance in patients with primary hyperparathyroidism. Proc Soc Exp Biol Med. 1975 Mar; 148(3):942-5. Ginsberg H, Olefsky JM, Reaven GM. PMID: 1129318.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    551. Demonstration of insulin resistance in untreated adult onset diabetic subjects with fasting hyperglycemia. J Clin Invest. 1975 Mar; 55(3):454-61. Ginsberg H, Kimmerling G, Olefsky JM, Reaven GM. PMID: 1117064; PMCID: PMC301772.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    552. Removal of insulin by perfused rat liver: effect of concentration. Metabolism. 1975 Feb; 24(2):153-60. Mondon CE, Olefsky JM, Dolkas CB, Reaven GM. PMID: 1113679.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    553. Insulin sensitivity of isolated perfused rat liver. Diabetes. 1975 Feb; 24(2):225-9. Mondon CE, Dolkas CB, Olefsky JM, Reaven GM. PMID: 1123110.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    554. Decreased insulin binding to lymphocytes from diabetic subjects. J Clin Invest. 1974 Dec; 54(6):1323-8. Olefsky JM, Reaven GM. PMID: 4474186; PMCID: PMC301686.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    555. Reappraisal of the role of insulin in hypertriglyceridemia. Am J Med. 1974 Oct; 57(4):551-60. Olefsky JM, Farquhar JW, Reaven GM. PMID: 4372881.
      View in: PubMed   Mentions: 68     Fields:    Translation:Humans
    556. Further evidence that insulin resistance exists in patients with chemical diabetes. Diabetes. 1974 Aug; 23(8):674-8. Ginsberg H, Olefsky JM, Reaven GM. PMID: 4852112.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    557. Insulin binding to isolated human adipocytes. Diabetes. 1974 Jul; 23(7):565-71. Olefsky JM, Jen P, Reaven GM, Alto P. PMID: 4366488.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    558. Effect of intravenous glucose infusion on plasma insulin removal rate. Metabolism. 1974 Jun; 23(6):543-8. Olefsky JM, Batchelder T, Colome S, Reaven GM. PMID: 4828443.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    559. Insulin and glucose responses to identical oral glucose tolerance tests performed forty-eight hours apart. Diabetes. 1974 May; 23(5):449-53. Olefsky JM, Reaven GM. PMID: 4830180.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    560. Relationship between insulin response during the intravenous glucose tolerance test, rate of fractional glucose removal and the degree of insulin resistance in normal adults. Diabetes. 1974 May; 23(5):454-9. Reaven GM, Olefsky JM. PMID: 4830181.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    561. The human lymphocyte: a model for the study of insulin-receptor interaction. J Clin Endocrinol Metab. 1974 Apr; 38(4):554-60. Olefsky J, Reaven GM. PMID: 4362393.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    562. Sex difference in the kinetics of triglyceride metabolism in normal and hypertriglyceridaemic human subjects. Eur J Clin Invest. 1974 Apr; 4(2):121-27. Olefsky J, Farquhar JW, Reaven GM. PMID: 4365003.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    563. Moderate ethanol ingestion and plasma triglyceride levels. A study in normal and hypertriglyceridemic persons. Ann Intern Med. 1974 Feb; 80(2):143-9. Ginsberg H, Olefsky J, Farquhar JW, Reaven GM. PMID: 4359737.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    564. Effects of weight reduction on obesity. Studies of lipid and carbohydrate metabolism in normal and hyperlipoproteinemic subjects. J Clin Invest. 1974 Jan; 53(1):64-76. Olefsky J, Reaven GM, Farquhar JW. PMID: 4357617; PMCID: PMC301439.
      View in: PubMed   Mentions: 71     Fields:    Translation:Humans
    565. Increased plasma glucose and insulin responses to high-carbohydrate feedings in normal subjects. J Clin Endocrinol Metab. 1974 Jan; 38(1):151-4. Reaven GM, Olefsky JM. PMID: 4809638.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    566. Disassociation of the plasma insulin response from the blood glucose concentration during glucose infusions in normal dogs. Metabolism. 1973 Oct; 22(10):1277-86. Olefsky J, Batchelder T, Farquhar JW, Reaven GM. PMID: 4784528.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    567. Relationship between fasting plasma lipid levels and adipose tissue morphology. Metabolism. 1973 Oct; 22(10):1311-7. Stern MP, Olefsky J, Farquhar JW, Reaven GM. PMID: 4784530.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    568. Relationship between fasting plasma insulin level and resistance to insulin-mediated glucose uptake in normal and diabetic subjects. Diabetes. 1973 Jul; 22(7):507-13. Olefsky J, Farquhar JW, Reaven G. PMID: 4719190.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    569. Do the oral and intravenous glucose tolerance tests provide similar diagnostic information in patients with chemical diabetes mellitus? Diabetes. 1973 Mar; 22(3):202-9. Olefsky JM, Farquhar JW, Reaven GM. PMID: 4689294.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    570. Does hyperglycaemia or hyperinsulinaemia characterise the patient with chemical diabetes? Lancet. 1972 Jun 10; 1(7763):1247-9. Reaven GM, Olefsky J, Farquhar JW. PMID: 4113513.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCTClinical Trials
    571. "Tertiary" hyperparathyroidism and apparent "cure" of vitamin-D-resistant rickets after removal of an ossifying mesenchymal tumor of the pharynx. N Engl J Med. 1972 Apr 06; 286(14):740-5. Olefsky J, Kempson R, Jones H, Reaven G. PMID: 4337228.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
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