Jerrold Olefsky

Title(s)Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Effects of Fractalkine on Beta Cell Function
    NIH R01DK101395Sep 19, 2014 - Aug 31, 2018
    Role: Principal Investigator
    Energetics & Breast Cancer: Obesity, Inflammation, Insulin Resistance & Risk
    NIH U54CA155435Jul 7, 2011 - May 31, 2017
    Role: Co-Investigator
    Molecular Mechanisms of Inflammation, Steatosis and Hepatic Insulin Resistance
    NIH R24DK090962Sep 30, 2010 - Aug 31, 2012
    Role: Principal Investigator
    Gene Networks controlling macrophage-adipocyte interactions in insulin
    NIH/NIDDK P01DK074868Apr 1, 2006 - Apr 30, 2017
    Role: Co-Investigator
    Estrogen Effects in Insulin Target and Granulosa Cells
    NIH R55DK068606Sep 30, 2004 - Aug 31, 2006
    Role: Principal Investigator
    Diabetes Research Center (DRC)
    NIH P30DK063491Dec 1, 2002 - Jun 30, 2025
    Role: Principal Investigator
    Estrogens and Insulin Resistance in Women
    NIH R01DK061964Jul 1, 2002 - May 31, 2007
    Role: Principal Investigator
    PKA & PKC Targeting Mechanisms (Program Project)
    NIH P01DK054441Dec 15, 1998 - Mar 31, 2019
    Role: Co-Investigator
    Center for Reproductive Science and Medicine
    NIH U54HD012303Apr 1, 1997 - Jul 31, 2016
    Role: Co-Investigator
    General Clinical Research Center
    NIH M01RR000827Jan 27, 1997 - Nov 30, 2010
    Role: Co-Investigator
    12/22 Limited Competition for the Continuation of the Diabetes Prevention Program Outcomes Study (DPPOS) - Clinical Center
    NIH U01DK048339Sep 10, 1994 - Jan 31, 2022
    Role: Principal Investigator
    Training Program in Diabetes Research
    NIH T32DK007494Jul 1, 1984 - Aug 31, 2022
    Role: Principal Investigator
    TRAINING PROGRAM IN DIABETES RESEARCH
    NIH T32AM007494Jul 1, 1984 - Jun 30, 1989
    Role: Principal Investigator
    Insulin Receptors and the Glucose Transport System
    NIH R01DK033651Aug 1, 1983 - Jun 30, 2014
    Role: Principal Investigator
    INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEM
    NIH R37DK033651Aug 1, 1983 - Jun 30, 2010
    Role: Principal Investigator
    MECHANISMS OF INSULIN RESISTANCE IN MAN
    NIH R01DK033649Aug 1, 1983 - Mar 31, 2002
    Role: Principal Investigator
    MECHANISMS OF INSULIN RESISTANCE IN MAN
    NIH R37DK033649Aug 1, 1983 - Mar 31, 1998
    Role: Principal Investigator
    INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEM
    NIH R01AM033651Aug 1, 1983 - Mar 31, 1990
    Role: Principal Investigator
    MECHANISMS OF INSULIN RESISTANCE IN MAN
    NIH R01AM033649Aug 1, 1983 - May 31, 1989
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chronic tissue inflammation and metabolic disease. Genes Dev. 2021 Mar 01; 35(5-6):307-328. Lee YS, Olefsky J. PMID: 33649162.
      View in: PubMed   Mentions: 1     Fields:    
    2. MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice. Cell Metab. 2021 Apr 06; 33(4):781-790.e5. Ying W, Gao H, Dos Reis FCG, Bandyopadhyay G, Ofrecio JM, Luo Z, Ji Y, Jin Z, Ly C, Olefsky JM. PMID: 33450179.
      View in: PubMed   Mentions: 4     Fields:    
    3. Positive Reinforcing Mechanisms between GPR120 and PPAR? Modulate Insulin Sensitivity. Cell Metab. 2020 06 02; 31(6):1173-1188.e5. Paschoal VA, Walenta E, Talukdar S, Pessentheiner AR, Osborn O, Hah N, Chi TJ, Tye GL, Armando AM, Evans RM, Chi NW, Quehenberger O, Olefsky JM, Oh DY. PMID: 32413335.
      View in: PubMed   Mentions: 5     Fields:    
    4. A Tribute to Robert Roy Henry-The Classic "Academic Triple Threat": Accomplished Researcher, Inspiring Teacher, and Compassionate Clinician. Diabetes Care. 2020 03; 43(3):522-525. Edelman S, Olefsky J, Mudaliar S, Ciaraldi T, Baron A. PMID: 31964787.
      View in: PubMed   Mentions:    Fields:    
    5. The role of macrophages in obesity-associated islet inflammation and ß-cell abnormalities. Nat Rev Endocrinol. 2020 02; 16(2):81-90. Ying W, Fu W, Lee YS, Olefsky JM. PMID: 31836875.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    6. Obesity Modulates Intestinal Intraepithelial T Cell Persistence, CD103 and CCR9 Expression, and Outcome in Dextran Sulfate Sodium-Induced Colitis. J Immunol. 2019 12 15; 203(12):3427-3435. Park C, Cheung KP, Limon N, Costanzo A, Barba C, Miranda N, Gargas S, Johnson AMF, Olefsky JM, Jameson JM. PMID: 31712385.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    7. TAZ Is a Negative Regulator of PPAR? Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance. Cell Metab. 2020 01 07; 31(1):162-173.e5. El Ouarrat D, Isaac R, Lee YS, Oh DY, Wollam J, Lackey D, Riopel M, Bandyopadhyay G, Seo JB, Sampath-Kumar R, Olefsky JM. PMID: 31708444.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    8. Microbiota-Produced N-Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance. Diabetes. 2019 07; 68(7):1415-1426. Wollam J, Riopel M, Xu YJ, Johnson AMF, Ofrecio JM, Ying W, El Ouarrat D, Chan LS, Han AW, Mahmood NA, Ryan CN, Lee YS, Watrous JD, Chordia MD, Pan D, Jain M, Olefsky JM. PMID: 31010956.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    9. Role of Host GPR120 in Mediating Dietary Omega-3 Fatty Acid Inhibition of Prostate Cancer. J Natl Cancer Inst. 2019 01 01; 111(1):52-59. Liang P, Henning SM, Guan J, Grogan T, Elashoff D, Olefsky JM, Cohen P, Aronson WJ. PMID: 30202902.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    10. Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting ß Cell Proliferation and Function in Obesity. Cell Metab. 2019 02 05; 29(2):457-474.e5. Ying W, Lee YS, Dong Y, Seidman JS, Yang M, Isaac R, Seo JB, Yang BH, Wollam J, Riopel M, McNelis J, Glass CK, Olefsky JM, Fu W. PMID: 30595478.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    11. Neuronal SIRT1 Regulates Metabolic and Reproductive Function and the Response to Caloric Restriction. J Endocr Soc. 2019 Feb 01; 3(2):427-445. Rickert E, Fernandez MO, Choi I, Gorman M, Olefsky JM, Webster NJG. PMID: 30746504.
      View in: PubMed   Mentions:
    12. CX3CL1-Fc treatment prevents atherosclerosis in Ldlr KO mice. Mol Metab. 2019 02; 20:89-101. Riopel M, Vassallo M, Ehinger E, Pattison J, Bowden K, Winkels H, Wilson M, de Jong R, Patel S, Balakrishna D, Bilakovics J, Fanjul A, Plonowski A, Larson CJ, Ley K, Cabrales P, Witztum JL, Olefsky JM, Lee YS. PMID: 30553772.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    13. Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity. Nat Metab. 2019 01; 1(1):86-97. Seo JB, Riopel M, Cabrales P, Huh JY, Bandyopadhyay GK, Andreyev AY, Murphy AN, Beeman SC, Smith GI, Klein S, Lee YS, Olefsky JM. PMID: 31528845.
      View in: PubMed   Mentions:
    14. N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model. Bioorg Med Chem. 2018 10 01; 26(18):5169-5180. Hoveyda HR, Fraser GL, Zoute L, Dutheuil G, Schils D, Brantis C, Lapin A, Parcq J, Guitard S, Lenoir F, Bousmaqui ME, Rorive S, Hospied S, Blanc S, Bernard J, Ooms F, McNelis JC, Olefsky JM. PMID: 30253886.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    15. Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis. Arthritis Res Ther. 2018 07 11; 20(1):145. Korman B, Marangoni RG, Lord G, Olefsky J, Tourtellotte W, Varga J. PMID: 29996896.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    16. RalA controls glucose homeostasis by regulating glucose uptake in brown fat. Proc Natl Acad Sci U S A. 2018 07 24; 115(30):7819-7824. Skorobogatko Y, Dragan M, Cordon C, Reilly SM, Hung CW, Xia W, Zhao P, Wallace M, Lackey DE, Chen XW, Osborn O, Bogner-Strauss JG, Theodorescu D, Metallo CM, Olefsky JM, Saltiel AR. PMID: 29915037.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    17. Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function. J Clin Invest. 2018 04 02; 128(4):1458-1470. Riopel M, Seo JB, Bandyopadhyay GK, Li P, Wollam J, Chung H, Jung SR, Murphy A, Wilson M, de Jong R, Patel S, Balakrishna D, Bilakovics J, Fanjul A, Plonowski A, Koh DS, Larson CJ, Olefsky JM, Lee YS. PMID: 29504946.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    18. An Integrated View of Immunometabolism. Cell. 2018 01 11; 172(1-2):22-40. Lee YS, Wollam J, Olefsky JM. PMID: 29328913.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimals
    19. Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity. Cell. 2017 Oct 05; 171(2):372-384.e12. Ying W, Riopel M, Bandyopadhyay G, Dong Y, Birmingham A, Seo JB, Ofrecio JM, Wollam J, Hernandez-Carretero A, Fu W, Li P, Olefsky JM. PMID: 28942920.
      View in: PubMed   Mentions: 242     Fields:    Translation:AnimalsCells
    20. Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling. J Clin Invest. 2017 Mar 01; 127(3):1019-1030. Ying W, Wollam J, Ofrecio JM, Bandyopadhyay G, El Ouarrat D, Lee YS, Oh DY, Li P, Osborn O, Olefsky JM. PMID: 28192375.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    21. Inflammatory mechanisms linking obesity and metabolic disease. J Clin Invest. 2017 01 03; 127(1):1-4. Saltiel AR, Olefsky JM. PMID: 28045402.
      View in: PubMed   Mentions: 301     Fields:    Translation:HumansAnimals
    22. Obese Neuronal PPAR? Knockout Mice Are Leptin Sensitive but Show Impaired Glucose Tolerance and Fertility. Endocrinology. 2017 01 01; 158(1):121-133. Fernandez MO, Sharma S, Kim S, Rickert E, Hsueh K, Hwang V, Olefsky JM, Webster NJ. PMID: 27841948.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    23. Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Cell. 2016 11 03; 167(4):973-984.e12. Li P, Liu S, Lu M, Bandyopadhyay G, Oh D, Imamura T, Johnson AMF, Sears D, Shen Z, Cui B, Kong L, Hou S, Liang X, Iovino S, Watkins SM, Ying W, Osborn O, Wollam J, Brenner M, Olefsky JM. PMID: 27814523.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    24. G protein-coupled receptors as targets for anti-diabetic therapeutics. Nat Rev Drug Discov. 2016 03; 15(3):161-72. Oh DY, Olefsky JM. PMID: 26822831.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    25. p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Rep. 2016 Jan 12; 14(2):255-68. Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor SS, Houslay MD, Baillie GS, Saltiel AR, Olefsky JM, Akassoglou K. PMID: 26748707.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    26. Regulation of metabolism by the innate immune system. Nat Rev Endocrinol. 2016 Jan; 12(1):15-28. Lackey DE, Olefsky JM. PMID: 26553134.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansAnimals
    27. Spatial Cognition in Adult and Aged Mice Exposed to High-Fat Diet. PLoS One. 2015; 10(10):e0140034. Kesby JP, Kim JJ, Scadeng M, Woods G, Kado DM, Olefsky JM, Jeste DV, Achim CL, Semenova S. PMID: 26448649.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    28. GPR43 Potentiates ß-Cell Function in Obesity. Diabetes. 2015 Sep; 64(9):3203-17. McNelis JC, Lee YS, Mayoral R, van der Kant R, Johnson AM, Wollam J, Olefsky JM. PMID: 26023106.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    29. High fat diet causes depletion of intestinal eosinophils associated with intestinal permeability. PLoS One. 2015; 10(4):e0122195. Johnson AM, Costanzo A, Gareau MG, Armando AM, Quehenberger O, Jameson JM, Olefsky JM. PMID: 25837594.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    30. Adipocyte SIRT1 knockout promotes PPAR? activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity. Mol Metab. 2015 May; 4(5):378-91. Mayoral R, Osborn O, McNelis J, Johnson AM, Oh DY, Izquierdo CL, Chung H, Li P, Traves PG, Bandyopadhyay G, Pessentheiner AR, Ofrecio JM, Cook JR, Qiang L, Accili D, Olefsky JM. PMID: 25973386.
      View in: PubMed   Mentions: 43     Fields:    
    31. Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature. 2015 Apr 16; 520(7547):388. Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky JM, Mohammadi M, Downes M, Evans RM. PMID: 25739500.
      View in: PubMed   Mentions:    Fields:    
    32. LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes. Nat Med. 2015 Mar; 21(3):239-247. Li P, Oh DY, Bandyopadhyay G, Lagakos WS, Talukdar S, Osborn O, Johnson A, Chung H, Maris M, Ofrecio JM, Taguchi S, Lu M, Olefsky JM. PMID: 25706874.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    33. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb; 21(2):159-65. Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M, Evans RM. PMID: 25559344.
      View in: PubMed   Mentions: 182     Fields:    Translation:Animals
    34. Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice. Diabetes. 2015 Apr; 64(4):1120-30. Morinaga H, Mayoral R, Heinrichsdorff J, Osborn O, Franck N, Hah N, Walenta E, Bandyopadhyay G, Pessentheiner AR, Chi TJ, Chung H, Bogner-Strauss JG, Evans RM, Olefsky JM, Oh DY. PMID: 25315009.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    35. Macrophages, immunity, and metabolic disease. Immunity. 2014 Jul 17; 41(1):36-48. McNelis JC, Olefsky JM. PMID: 25035952.
      View in: PubMed   Mentions: 242     Fields:    Translation:HumansAnimalsCells
    36. Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature. 2014 Sep 18; 513(7518):436-9. Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky JM, Mohammadi M, Downes M, Evans RM. PMID: 25043058.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimals
    37. A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. Nat Med. 2014 Aug; 20(8):942-7. Oh DY, Walenta E, Akiyama TE, Lagakos WS, Lackey D, Pessentheiner AR, Sasik R, Hah N, Chi TJ, Cox JM, Powels MA, Di Salvo J, Sinz C, Watkins SM, Armando AM, Chung H, Evans RM, Quehenberger O, McNelis J, Bogner-Strauss JG, Olefsky JM. PMID: 24997608.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    38. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014 Aug; 124(8):3566-78. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner DA, Seki E. PMID: 24983318.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    39. Increased adipocyte O2 consumption triggers HIF-1a, causing inflammation and insulin resistance in obesity. Cell. 2014 Jun 05; 157(6):1339-1352. Lee YS, Kim JW, Osborne O, Oh DY, Sasik R, Schenk S, Chen A, Chung H, Murphy A, Watkins SM, Quehenberger O, Johnson RS, Olefsky JM. PMID: 24906151.
      View in: PubMed   Mentions: 138     Fields:    Translation:AnimalsCells
    40. C/EBPa regulates macrophage activation and systemic metabolism. Am J Physiol Endocrinol Metab. 2014 May 15; 306(10):E1144-54. Lee B, Qiao L, Lu M, Yoo HS, Cheung W, Mak R, Schaack J, Feng GS, Chi NW, Olefsky JM, Shao J. PMID: 24691027.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    41. Pro-inflammatory macrophages increase in skeletal muscle of high fat-fed mice and correlate with metabolic risk markers in humans. Obesity (Silver Spring). 2014 Mar; 22(3):747-57. Fink LN, Costford SR, Lee YS, Jensen TE, Bilan PJ, Oberbach A, Blüher M, Olefsky JM, Sams A, Klip A. PMID: 24030890.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    42. NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids. Cell. 2013 Sep 26; 155(1):200-214. Li P, Spann NJ, Kaikkonen MU, Lu M, Oh DY, Fox JN, Bandyopadhyay G, Talukdar S, Xu J, Lagakos WS, Patsouris D, Armando A, Quehenberger O, Dennis EA, Watkins SM, Auwerx J, Glass CK, Olefsky JM. PMID: 24074869.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    43. Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. J Clin Invest. 2013 Oct; 123(10):4318-28. Ravnskjaer K, Hogan MF, Lackey D, Tora L, Dent SY, Olefsky J, Montminy M. PMID: 24051374.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    44. Quantitative proteomic and functional analysis of liver mitochondria from high fat diet (HFD) diabetic mice. Mol Cell Proteomics. 2013 Dec; 12(12):3744-58. Guo Y, Darshi M, Ma Y, Perkins GA, Shen Z, Haushalter KJ, Saito R, Chen A, Lee YS, Patel HH, Briggs SP, Ellisman MH, Olefsky JM, Taylor SS. PMID: 24030101.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    45. The fractalkine/CX3CR1 system regulates ß cell function and insulin secretion. Cell. 2013 Apr 11; 153(2):413-25. Lee YS, Morinaga H, Kim JJ, Lagakos W, Taylor S, Keshwani M, Perkins G, Dong H, Kayali AG, Sweet IR, Olefsky J. PMID: 23582329.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    46. Free fatty acids induce Lhb mRNA but suppress Fshb mRNA in pituitary LßT2 gonadotropes and diet-induced obesity reduces FSH levels in male mice and disrupts the proestrous LH/FSH surge in female mice. Endocrinology. 2013 Jun; 154(6):2188-99. Sharma S, Morinaga H, Hwang V, Fan W, Fernandez MO, Varki N, Olefsky JM, Webster NJ. PMID: 23525221.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    47. Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues. J Biol Chem. 2013 Apr 12; 288(15):10722-35. Lu M, Sarruf DA, Li P, Osborn O, Sanchez-Alavez M, Talukdar S, Chen A, Bandyopadhyay G, Xu J, Morinaga H, Dines K, Watkins S, Kaiyala K, Schwartz MW, Olefsky JM. PMID: 23457303.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    48. The origins and drivers of insulin resistance. Cell. 2013 Feb 14; 152(4):673-84. Johnson AM, Olefsky JM. PMID: 23415219.
      View in: PubMed   Mentions: 205     Fields:    Translation:HumansCells
    49. An inhibitor of the protein kinases TBK1 and IKK-? improves obesity-related metabolic dysfunctions in mice. Nat Med. 2013 Mar; 19(3):313-21. Reilly SM, Chiang SH, Decker SJ, Chang L, Uhm M, Larsen MJ, Rubin JR, Mowers J, White NM, Hochberg I, Downes M, Yu RT, Liddle C, Evans RM, Oh D, Li P, Olefsky JM, Saltiel AR. PMID: 23396211.
      View in: PubMed   Mentions: 160     Fields:    Translation:AnimalsCells
    50. The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) initiative: rationale and design. Cancer Causes Control. 2013 Apr; 24(4):695-704. Patterson RE, Colditz GA, Hu FB, Schmitz KH, Ahima RS, Brownson RC, Carson KR, Chavarro JE, Chodosh LA, Gehlert S, Gill J, Glanz K, Haire-Joshu D, Herbst KL, Hoehner CM, Hovmand PS, Irwin ML, Jacobs LA, James AS, Jones LW, Kerr J, Kibel AS, King IB, Ligibel JA, Meyerhardt JA, Natarajan L, Neuhouser ML, Olefsky JM, Proctor EK, Redline S, Rock CL, Rosner B, Sarwer DB, Schwartz JS, Sears DD, Sesso HD, Stampfer MJ, Subramanian SV, Taveras EM, Tchou J, Thompson B, Troxel AB, Wessling-Resnick M, Wolin KY, Thornquist MD. PMID: 23378138.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    51. Restoration of euglycemia after duodenal bypass surgery is reliant on central and peripheral inputs in Zucker fa/fa rats. Diabetes. 2013 Apr; 62(4):1074-83. Jiao J, Bae EJ, Bandyopadhyay G, Oliver J, Marathe C, Chen M, Hsu JY, Chen Y, Tian H, Olefsky JM, Saberi M. PMID: 23248171.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    52. Inverse regulation of inflammation and mitochondrial function in adipose tissue defines extreme insulin sensitivity in morbidly obese patients. Diabetes. 2013 Mar; 62(3):855-63. Qatanani M, Tan Y, Dobrin R, Greenawalt DM, Hu G, Zhao W, Olefsky JM, Sears DD, Kaplan LM, Kemp DM. PMID: 23223024.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    53. Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 2012 Sep 05; 16(3):311-21. Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M. PMID: 22958918.
      View in: PubMed   Mentions: 104     Fields:    Translation:Animals
    54. Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nat Med. 2012 Sep; 18(9):1407-12. Talukdar S, Oh DY, Bandyopadhyay G, Li D, Xu J, McNelis J, Lu M, Li P, Yan Q, Zhu Y, Ofrecio J, Lin M, Brenner MB, Olefsky JM. PMID: 22863787.
      View in: PubMed   Mentions: 318     Fields:    Translation:AnimalsCells
    55. Fetuin-A: the missing link in lipid-induced inflammation. Nat Med. 2012 Aug; 18(8):1182-3. Heinrichsdorff J, Olefsky JM. PMID: 22869185.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
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    129. JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. J Biol Chem. 2005 Oct 21; 280(42):35361-71. Nguyen MT, Satoh H, Favelyukis S, Babendure JL, Imamura T, Sbodio JI, Zalevsky J, Dahiyat BI, Chi NW, Olefsky JM. PMID: 16085647.
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    130. Topiramate treatment causes skeletal muscle insulin sensitization and increased Acrp30 secretion in high-fat-fed male Wistar rats. Am J Physiol Endocrinol Metab. 2005 Dec; 289(6):E1015-22. Wilkes JJ, Nguyen MT, Bandyopadhyay GK, Nelson E, Olefsky JM. PMID: 16030065.
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    131. VAMPIRE microarray suite: a web-based platform for the interpretation of gene expression data. Nucleic Acids Res. 2005 Jul 01; 33(Web Server issue):W627-32. Hsiao A, Ideker T, Olefsky JM, Subramaniam S. PMID: 15980550.
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    132. G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes. Mol Endocrinol. 2005 Nov; 19(11):2760-8. Usui I, Imamura T, Babendure JL, Satoh H, Lu JC, Hupfeld CJ, Olefsky JM. PMID: 15994203.
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    133. Adenovirus-mediated adiponectin expression augments skeletal muscle insulin sensitivity in male Wistar rats. Diabetes. 2005 May; 54(5):1304-13. Satoh H, Nguyen MT, Trujillo M, Imamura T, Usui I, Scherer PE, Olefsky JM. PMID: 15855314.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    134. Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action. Nat Med. 2005 May; 11(5):567-71. Bard-Chapeau EA, Hevener AL, Long S, Zhang EE, Olefsky JM, Feng GS. PMID: 15821749.
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    135. Variation in the gene for muscle-specific AMP deaminase is associated with insulin clearance, a highly heritable trait. Diabetes. 2005 Apr; 54(4):1222-7. Goodarzi MO, Taylor KD, Guo X, Quiñones MJ, Cui J, Li X, Hang T, Yang H, Holmes E, Hsueh WA, Olefsky J, Rotter JI. PMID: 15793265.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    136. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med. 2005 Feb; 11(2):191-8. Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M. PMID: 15685170.
      View in: PubMed   Mentions: 659     Fields:    Translation:AnimalsCells
    137. Topiramate is an insulin-sensitizing compound in vivo with direct effects on adipocytes in female ZDF rats. Am J Physiol Endocrinol Metab. 2005 Mar; 288(3):E617-24. Wilkes JJ, Nelson E, Osborne M, Demarest KT, Olefsky JM. PMID: 15536205.
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    138. Insulin-induced beta-arrestin1 Ser-412 phosphorylation is a mechanism for desensitization of ERK activation by Galphai-coupled receptors. J Biol Chem. 2005 Jan 14; 280(2):1016-23. Hupfeld CJ, Resnik JL, Ugi S, Olefsky JM. PMID: 15520010.
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    139. Mechanism of SHIP-mediated inhibition of insulin- and platelet-derived growth factor-stimulated mitogen-activated protein kinase activity in 3T3-L1 adipocytes. Mol Endocrinol. 2005 Feb; 19(2):421-30. Sharma PM, Son HS, Ugi S, Ricketts W, Olefsky JM. PMID: 15486046.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    140. beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1. Mol Cell Biol. 2004 Oct; 24(20):8929-37. Usui I, Imamura T, Huang J, Satoh H, Shenoy SK, Lefkowitz RJ, Hupfeld CJ, Olefsky JM. PMID: 15456867.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    141. Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes. Mol Cell Biol. 2004 Oct; 24(19):8778-89. Ugi S, Imamura T, Maegawa H, Egawa K, Yoshizaki T, Shi K, Obata T, Ebina Y, Kashiwagi A, Olefsky JM. PMID: 15367694.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    142. Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3). Proc Natl Acad Sci U S A. 2004 Sep 07; 101(36):13296-301. Wiedmer T, Zhao J, Li L, Zhou Q, Hevener A, Olefsky JM, Curtiss LK, Sims PJ. PMID: 15328404.
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    143. GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation. EMBO J. 2004 Jul 21; 23(14):2821-9. Usui I, Imamura T, Satoh H, Huang J, Babendure JL, Hupfeld CJ, Olefsky JM. PMID: 15241473.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    144. Adenovirus-mediated chronic "hyper-resistinemia" leads to in vivo insulin resistance in normal rats. J Clin Invest. 2004 Jul; 114(2):224-31. Satoh H, Nguyen MT, Miles PD, Imamura T, Usui I, Olefsky JM. PMID: 15254589.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    145. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat Med. 2004 May; 10(5):530-4. Koo SH, Satoh H, Herzig S, Lee CH, Hedrick S, Kulkarni R, Evans RM, Olefsky J, Montminy M. PMID: 15107844.
      View in: PubMed   Mentions: 213     Fields:    Translation:HumansAnimalsCells
    146. Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. J Biol Chem. 2004 May 21; 279(21):22715-26. Yoshizaki T, Maegawa H, Egawa K, Ugi S, Nishio Y, Imamura T, Kobayashi T, Tamura S, Olefsky JM, Kashiwagi A. PMID: 15016818.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    147. Annexin II is a thiazolidinedione-responsive gene involved in insulin-induced glucose transporter isoform 4 translocation in 3T3-L1 adipocytes. Endocrinology. 2004 Apr; 145(4):1579-86. Huang J, Hsia SH, Imamura T, Usui I, Olefsky JM. PMID: 14726447.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    148. Regulation of the insulin receptor by protein kinase C isoenzymes: preferential interaction with beta isoenzymes and interaction with the catalytic domain of betaII. Cell Signal. 2004 Jan; 16(1):97-104. Pillay TS, Xiao S, Keranen L, Olefsky JM. PMID: 14607280.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    149. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem. 2004 Mar 26; 279(13):12152-62. Pajvani UB, Hawkins M, Combs TP, Rajala MW, Doebber T, Berger JP, Wagner JA, Wu M, Knopps A, Xiang AH, Utzschneider KM, Kahn SE, Olefsky JM, Buchanan TA, Scherer PE. PMID: 14699128.
      View in: PubMed   Mentions: 319     Fields:    Translation:HumansAnimalsCells
    150. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15712-7. He W, Barak Y, Hevener A, Olson P, Liao D, Le J, Nelson M, Ong E, Olefsky JM, Evans RM. PMID: 14660788.
      View in: PubMed   Mentions: 387     Fields:    Translation:AnimalsCells
    151. Muscle-specific Pparg deletion causes insulin resistance. Nat Med. 2003 Dec; 9(12):1491-7. Hevener AL, He W, Barak Y, Le J, Bandyopadhyay G, Olson P, Wilkes J, Evans RM, Olefsky J. PMID: 14625542.
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    152. Cellular effects of small molecule PTP1B inhibitors on insulin signaling. Biochemistry. 2003 Nov 11; 42(44):12792-804. Xie L, Lee SY, Andersen JN, Waters S, Shen K, Guo XL, Moller NP, Olefsky JM, Lawrence DS, Zhang ZY. PMID: 14596593.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    153. Chronic endothelin-1 treatment leads to insulin resistance in vivo. Diabetes. 2003 Aug; 52(8):1904-9. Wilkes JJ, Hevener A, Olefsky J. PMID: 12882904.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    154. Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin. Mol Cell Biol. 2003 Jul; 23(14):4892-900. Imamura T, Huang J, Usui I, Satoh H, Bever J, Olefsky JM. PMID: 12832475.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    155. The effect of oral glucosamine sulfate on insulin sensitivity in human subjects. Diabetes Care. 2003 Jun; 26(6):1941-2. Yu JG, Boies SM, Olefsky JM. PMID: 12766141.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    156. Inhibition of mitochondrial Na+-Ca2+ exchanger increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets. Diabetes. 2003 Apr; 52(4):965-73. Lee B, Miles PD, Vargas L, Luan P, Glasco S, Kushnareva Y, Kornbrust ES, Grako KA, Wollheim CB, Maechler P, Olefsky JM, Anderson CM. PMID: 12663468.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    157. Effect of heterozygous PPARgamma deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding. Am J Physiol Endocrinol Metab. 2003 Mar; 284(3):E618-26. Miles PD, Barak Y, Evans RM, Olefsky JM. PMID: 12556354.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    158. Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3T3-L1 adipocytes. J Biol Chem. 2003 Apr 18; 278(16):13765-74. Usui I, Imamura T, Huang J, Satoh H, Olefsky JM. PMID: 12566459.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    159. Effect of obesity on susceptibility to fatty acid-induced peripheral tissue insulin resistance. Metabolism. 2003 Feb; 52(2):233-8. Kruszynska YT, Olefsky JM, Frias JP. PMID: 12601639.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    160. Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A. 2003 Jan 07; 100(1):161-6. Hupfeld CJ, Dalle S, Olefsky JM. PMID: 12509508.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    161. Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistance. Diabetes. 2002 Nov; 51(11):3176-88. Ruan H, Miles PD, Ladd CM, Ross K, Golub TR, Olefsky JM, Lodish HF. PMID: 12401708.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    162. The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. Diabetes. 2002 Oct; 51(10):2968-74. Yu JG, Javorschi S, Hevener AL, Kruszynska YT, Norman RA, Sinha M, Olefsky JM. PMID: 12351435.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansAnimalsCTClinical Trials
    163. Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1. Mol Cell Biol. 2002 Sep; 22(17):6272-85. Dalle S, Imamura T, Rose DW, Worrall DS, Ugi S, Hupfeld CJ, Olefsky JM. PMID: 12167719.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    164. Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells. J Biol Chem. 2002 Aug 30; 277(35):32099-108. Liu F, Usui I, Evans LG, Austin DA, Mellon PL, Olefsky JM, Webster NJ. PMID: 12050161.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    165. Female rats do not exhibit free fatty acid-induced insulin resistance. Diabetes. 2002 Jun; 51(6):1907-12. Hevener A, Reichart D, Janez A, Olefsky J. PMID: 12031980.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    166. Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups. Am J Hum Genet. 2002 May; 70(5):1152-71. Herrnstadt C, Elson JL, Fahy E, Preston G, Turnbull DM, Anderson C, Ghosh SS, Olefsky JM, Beal MF, Davis RE, Howell N. PMID: 11938495.
      View in: PubMed   Mentions: 187     Fields:    Translation:Humans
    167. Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling. Mol Cell Biol. 2002 Apr; 22(7):2375-87. Ugi S, Imamura T, Ricketts W, Olefsky JM. PMID: 11884620.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    168. Phosphatidylinositol 3-kinase is required for insulin-stimulated tyrosine phosphorylation of Shc in 3T3-L1 adipocytes. J Biol Chem. 2002 May 24; 277(21):18592-7. Ugi S, Sharma PM, Ricketts W, Imamura T, Olefsky JM. PMID: 11897789.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    169. GnRH activates ERK1/2 leading to the induction of c-fos and LHbeta protein expression in LbetaT2 cells. Mol Endocrinol. 2002 Mar; 16(3):419-34. Liu F, Austin DA, Mellon PL, Olefsky JM, Webster NJ. PMID: 11875099.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    170. The effects of intracellular calcium depletion on insulin signaling in 3T3-L1 adipocytes. Mol Endocrinol. 2002 Feb; 16(2):378-89. Worrall DS, Olefsky JM. PMID: 11818508.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    171. Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation. J Clin Endocrinol Metab. 2002 Jan; 87(1):226-34. Kruszynska YT, Worrall DS, Ofrecio J, Frias JP, Macaraeg G, Olefsky JM. PMID: 11788651.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    172. Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):303-8. Barak Y, Liao D, He W, Ong ES, Nelson MC, Olefsky JM, Boland R, Evans RM. PMID: 11756685.
      View in: PubMed   Mentions: 179     Fields:    Translation:Animals
    173. Nuclear receptor minireview series. J Biol Chem. 2001 Oct 05; 276(40):36863-4. Olefsky JM. PMID: 11459855.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimals
    174. Prospects for research in diabetes mellitus. JAMA. 2001 Feb 07; 285(5):628-32. Olefsky JM. PMID: 11176871.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    175. Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists. J Clin Invest. 2000 Aug; 106(4):467-72. Olefsky JM. PMID: 10953021.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimals
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