Loading...

Jerrold Olefsky

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0673
La Jolla CA 92093
Phone858-534-6651
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Effects of Fractalkine on Beta Cell Function
    NIH/NIDDK R01DK101395Sep 19, 2014 - Aug 31, 2018
    Role: Principal Investigator
    Energetics &Breast Cancer: Obesity, Inflammation, Insulin Resistance &Risk
    NIH/NCI U54CA155435Jul 7, 2011 - May 31, 2016
    Role: Co-Investigator
    Molecular Mechanisms of Inflammation, Steatosis and Hepatic Insulin Resistance
    NIH/NIDDK R24DK090962Sep 30, 2010 - Aug 31, 2012
    Role: Principal Investigator
    Gene Networks controlling macrophage-adipocyte interactions in insulin
    NIH/NIDDK P01DK074868Apr 1, 2006 - Apr 30, 2017
    Role: Co-Investigator
    Estrogen Effects in Insulin Target and Granulosa Cells
    NIH/NIDDK R55DK068606Sep 30, 2004 - Aug 31, 2006
    Role: Principal Investigator
    Diabetes Research Center (DRC)
    NIH/NIDDK P30DK063491Dec 1, 2002 - Apr 30, 2018
    Role: Principal Investigator
    Estrogens and Insulin Resistance in Women
    NIH/NIDDK R01DK061964Jul 1, 2002 - May 31, 2007
    Role: Principal Investigator
    PKA & PKC Targeting Mechanisms (Program Project)
    NIH/NIDDK P01DK054441Dec 15, 1998 - Mar 31, 2018
    Role: Co-Investigator
    Diabetes Prevention Program Outcomes Study (DPPOS) Phase 3 ? Research Project
    NIH/NIDDK U01DK048339Sep 10, 1994 - Jan 31, 2021
    Role: Principal Investigator
    TRAINING PROGRAM IN DIABETES RESEARCH
    NIH/NIDDK T32DK007494Jul 1, 1984 - Aug 31, 2022
    Role: Principal Investigator
    TRAINING PROGRAM IN DIABETES RESEARCH
    NIH/NIADDK T32AM007494Jul 1, 1984 - Jun 30, 1989
    Role: Principal Investigator
    Insulin Receptors and the Glucose Transport System
    NIH/NIDDK R01DK033651Aug 1, 1983 - Jun 30, 2014
    Role: Principal Investigator
    INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEM
    NIH/NIDDK R37DK033651Aug 1, 1983 - Jun 30, 2010
    Role: Principal Investigator
    MECHANISMS OF INSULIN RESISTANCE IN MAN
    NIH/NIDDK R01DK033649Aug 1, 1983 - Mar 31, 2002
    Role: Principal Investigator
    MECHANISMS OF INSULIN RESISTANCE IN MAN
    NIH/NIDDK R37DK033649Aug 1, 1983 - Mar 31, 1998
    Role: Principal Investigator
    INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEM
    NIH/NIADDK R01AM033651Aug 1, 1983 - Mar 31, 1990
    Role: Principal Investigator
    MECHANISMS OF INSULIN RESISTANCE IN MAN
    NIH/NIADDK R01AM033649Aug 1, 1983 - May 31, 1989
    Role: Principal Investigator
    Center for Reproductive Science and Medicine
    NIH/NICHD U54HD012303Dec 1, 1978 - Mar 31, 2014
    Role: Co-Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Korman B, Marangoni RG, Lord G, Olefsky J, Tourtellotte W, Varga J. Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis. Arthritis Res Ther. 2018 Jul 11; 20(1):145. PMID: 29996896.
      View in: PubMed
    2. Skorobogatko Y, Dragan M, Cordon C, Reilly SM, Hung CW, Xia W, Zhao P, Wallace M, Lackey DE, Chen XW, Osborn O, Bogner-Strauss JG, Theodorescu D, Metallo CM, Olefsky J, Saltiel AR. RalA controls glucose homeostasis by regulating glucose uptake in brown fat. Proc Natl Acad Sci U S A. 2018 Jun 18. PMID: 29915037.
      View in: PubMed
    3. Riopel M, Seo JB, Bandyopadhyay GK, Li P, Wollam J, Chung H, Jung SR, Murphy A, Wilson M, de Jong R, Patel S, Balakrishna D, Bilakovics J, Fanjul A, Plonowski A, Koh DS, Larson CJ, Olefsky J, Lee YS. Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function. J Clin Invest. 2018 Apr 02; 128(4):1458-1470. PMID: 29504946.
      View in: PubMed
    4. Lee YS, Wollam J, Olefsky J. An Integrated View of Immunometabolism. Cell. 2018 Jan 11; 172(1-2):22-40. PMID: 29328913.
      View in: PubMed
    5. Ying W, Riopel M, Bandyopadhyay G, Dong Y, Birmingham A, Seo JB, Ofrecio JM, Wollam J, Hernandez-Carretero A, Fu W, Li P, Olefsky J. Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity. Cell. 2017 Oct 05; 171(2):372-384.e12. PMID: 28942920.
      View in: PubMed
    6. Ying W, Wollam J, Ofrecio JM, Bandyopadhyay G, El Ouarrat D, Lee YS, Oh DY, Li P, Osborn O, Olefsky J. Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling. J Clin Invest. 2017 Mar 01; 127(3):1019-1030. PMID: 28192375.
      View in: PubMed
    7. Saltiel AR, Olefsky J. Inflammatory mechanisms linking obesity and metabolic disease. J Clin Invest. 2017 Jan 03; 127(1):1-4. PMID: 28045402.
      View in: PubMed
    8. Fernandez MO, Sharma S, Kim S, Rickert E, Hsueh K, Hwang V, Olefsky J, Webster NJ. Obese Neuronal PPAR? Knockout Mice Are Leptin Sensitive but Show Impaired Glucose Tolerance and Fertility. Endocrinology. 2017 01 01; 158(1):121-133. PMID: 27841948.
      View in: PubMed
    9. Li P, Liu S, Lu M, Bandyopadhyay G, Oh D, Imamura T, Johnson AMF, Sears D, Shen Z, Cui B, Kong L, Hou S, Liang X, Iovino S, Watkins SM, Ying W, Osborn O, Wollam J, Brenner M, Olefsky J. Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Cell. 2016 11 03; 167(4):973-984.e12. PMID: 27814523.
      View in: PubMed
    10. Oh DY, Olefsky J. G protein-coupled receptors as targets for anti-diabetic therapeutics. Nat Rev Drug Discov. 2016 03; 15(3):161-72. PMID: 26822831.
      View in: PubMed
    11. Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor SS, Houslay MD, Baillie GS, Saltiel AR, Olefsky J, Akassoglou K. p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Rep. 2016 Jan 12; 14(2):255-68. PMID: 26748707; PMCID: PMC4831919.
    12. Lackey DE, Olefsky J. Regulation of metabolism by the innate immune system. Nat Rev Endocrinol. 2016 Jan; 12(1):15-28. PMID: 26553134.
      View in: PubMed
    13. Kesby JP, Kim JJ, Scadeng M, Woods G, Kado DM, Olefsky J, Jeste DV, Achim CL, Semenova S. Spatial Cognition in Adult and Aged Mice Exposed to High-Fat Diet. PLoS One. 2015; 10(10):e0140034. PMID: 26448649; PMCID: PMC4598128.
    14. McNelis JC, Lee YS, Mayoral R, van der Kant R, Johnson AM, Wollam J, Olefsky J. GPR43 Potentiates ß-Cell Function in Obesity. Diabetes. 2015 Sep; 64(9):3203-17. PMID: 26023106; PMCID: PMC4542437.
    15. Johnson AM, Costanzo A, Gareau MG, Armando AM, Quehenberger O, Jameson JM, Olefsky J. High fat diet causes depletion of intestinal eosinophils associated with intestinal permeability. PLoS One. 2015; 10(4):e0122195. PMID: 25837594; PMCID: PMC4383570.
    16. Mayoral R, Osborn O, McNelis J, Johnson AM, Oh DY, Izquierdo CL, Chung H, Li P, Traves PG, Bandyopadhyay G, Pessentheiner AR, Ofrecio JM, Cook JR, Qiang L, Accili D, Olefsky J. Adipocyte SIRT1 knockout promotes PPAR? activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity. Mol Metab. 2015 May; 4(5):378-91. PMID: 25973386; PMCID: PMC4421024.
    17. Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky J, Mohammadi M, Downes M, Evans RM. Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature. 2015 Apr 16; 520(7547):388. PMID: 25739500.
      View in: PubMed
    18. Li P, Oh DY, Bandyopadhyay G, Lagakos WS, Talukdar S, Osborn O, Johnson A, Chung H, Maris M, Ofrecio JM, Taguchi S, Lu M, Olefsky J. LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes. Nat Med. 2015 Mar; 21(3):239-247. PMID: 25706874; PMCID: PMC4429798.
    19. Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky J, Saltiel AR, Downes M, Evans RM. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb; 21(2):159-65. PMID: 25559344; PMCID: PMC4320010.
    20. Morinaga H, Mayoral R, Heinrichsdorff J, Osborn O, Franck N, Hah N, Walenta E, Bandyopadhyay G, Pessentheiner AR, Chi TJ, Chung H, Bogner-Strauss JG, Evans RM, Olefsky J, Oh DY. Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice. Diabetes. 2015 Apr; 64(4):1120-30. PMID: 25315009; PMCID: PMC4375077.
    21. McNelis JC, Olefsky J. Macrophages, immunity, and metabolic disease. Immunity. 2014 Jul 17; 41(1):36-48. PMID: 25035952.
      View in: PubMed
    22. Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky J, Mohammadi M, Downes M, Evans RM. Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature. 2014 Sep 18; 513(7518):436-9. PMID: 25043058; PMCID: PMC4184286.
    23. Oh DY, Walenta E, Akiyama TE, Lagakos WS, Lackey D, Pessentheiner AR, Sasik R, Hah N, Chi TJ, Cox JM, Powels MA, Di Salvo J, Sinz C, Watkins SM, Armando AM, Chung H, Evans RM, Quehenberger O, McNelis J, Bogner-Strauss JG, Olefsky J. A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. Nat Med. 2014 Aug; 20(8):942-7. PMID: 24997608; PMCID: PMC4126875.
    24. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky J, Karin M, Brenner DA, Seki E. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014 Aug; 124(8):3566-78. PMID: 24983318; PMCID: PMC4109552.
    25. Lee YS, Kim JW, Osborne O, Oh DY, Sasik R, Schenk S, Chen A, Chung H, Murphy A, Watkins SM, Quehenberger O, Johnson RS, Olefsky J. Increased adipocyte O2 consumption triggers HIF-1a, causing inflammation and insulin resistance in obesity. Cell. 2014 Jun 05; 157(6):1339-52. PMID: 24906151.
      View in: PubMed
    26. Lee B, Qiao L, Lu M, Yoo HS, Cheung W, Mak R, Schaack J, Feng GS, Chi NW, Olefsky J, Shao J. C/EBPa regulates macrophage activation and systemic metabolism. Am J Physiol Endocrinol Metab. 2014 May 15; 306(10):E1144-54. PMID: 24691027; PMCID: PMC4025063.
    27. Fink LN, Costford SR, Lee YS, Jensen TE, Bilan PJ, Oberbach A, Blüher M, Olefsky J, Sams A, Klip A. Pro-inflammatory macrophages increase in skeletal muscle of high fat-fed mice and correlate with metabolic risk markers in humans. Obesity (Silver Spring). 2014 Mar; 22(3):747-57. PMID: 24030890.
      View in: PubMed
    28. Li P, Spann NJ, Kaikkonen MU, Lu M, Oh DY, Fox JN, Bandyopadhyay G, Talukdar S, Xu J, Lagakos WS, Patsouris D, Armando A, Quehenberger O, Dennis EA, Watkins SM, Auwerx J, Glass CK, Olefsky J. NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids. Cell. 2013 Sep 26; 155(1):200-214. PMID: 24074869; PMCID: PMC4131699.
    29. Ravnskjaer K, Hogan MF, Lackey D, Tora L, Dent SY, Olefsky J, Montminy M. Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. J Clin Invest. 2013 Oct; 123(10):4318-28. PMID: 24051374; PMCID: PMC3784539.
    30. Guo Y, Darshi M, Ma Y, Perkins GA, Shen Z, Haushalter KJ, Saito R, Chen A, Lee YS, Patel HH, Briggs SP, Ellisman MH, Olefsky J, Taylor SS. Quantitative proteomic and functional analysis of liver mitochondria from high fat diet (HFD) diabetic mice. Mol Cell Proteomics. 2013 Dec; 12(12):3744-58. PMID: 24030101; PMCID: PMC3861721.
    31. Lee YS, Morinaga H, Kim JJ, Lagakos W, Taylor S, Keshwani M, Perkins G, Dong H, Kayali AG, Sweet IR, Olefsky J. The fractalkine/CX3CR1 system regulates ß cell function and insulin secretion. Cell. 2013 Apr 11; 153(2):413-25. PMID: 23582329; PMCID: PMC3717389.
    32. Sharma S, Morinaga H, Hwang V, Fan W, Fernandez MO, Varki N, Olefsky J, Webster NJ. Free fatty acids induce Lhb mRNA but suppress Fshb mRNA in pituitary LßT2 gonadotropes and diet-induced obesity reduces FSH levels in male mice and disrupts the proestrous LH/FSH surge in female mice. Endocrinology. 2013 Jun; 154(6):2188-99. PMID: 23525221; PMCID: PMC3740488.
    33. Lu M, Sarruf DA, Li P, Osborn O, Sanchez-Alavez M, Talukdar S, Chen A, Bandyopadhyay G, Xu J, Morinaga H, Dines K, Watkins S, Kaiyala K, Schwartz MW, Olefsky J. Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues. J Biol Chem. 2013 Apr 12; 288(15):10722-35. PMID: 23457303; PMCID: PMC3624452.
    34. Johnson AM, Olefsky J. The origins and drivers of insulin resistance. Cell. 2013 Feb 14; 152(4):673-84. PMID: 23415219.
      View in: PubMed
    35. Reilly SM, Chiang SH, Decker SJ, Chang L, Uhm M, Larsen MJ, Rubin JR, Mowers J, White NM, Hochberg I, Downes M, Yu RT, Liddle C, Evans RM, Oh D, Li P, Olefsky J, Saltiel AR. An inhibitor of the protein kinases TBK1 and IKK-? improves obesity-related metabolic dysfunctions in mice. Nat Med. 2013 Mar; 19(3):313-21. PMID: 23396211; PMCID: PMC3594079.
    36. Patterson RE, Colditz GA, Hu FB, Schmitz KH, Ahima RS, Brownson RC, Carson KR, Chavarro JE, Chodosh LA, Gehlert S, Gill J, Glanz K, Haire-Joshu D, Herbst KL, Hoehner CM, Hovmand PS, Irwin ML, Jacobs LA, James AS, Jones LW, Kerr J, Kibel AS, King IB, Ligibel JA, Meyerhardt JA, Natarajan L, Neuhouser ML, Olefsky J, Proctor EK, Redline S, Rock CL, Rosner B, Sarwer DB, Schwartz JS, Sears DD, Sesso HD, Stampfer MJ, Subramanian SV, Taveras EM, Tchou J, Thompson B, Troxel AB, Wessling-Resnick M, Wolin KY, Thornquist MD. The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) initiative: rationale and design. Cancer Causes Control. 2013 Apr; 24(4):695-704. PMID: 23378138; PMCID: PMC3602225.
    37. Jiao J, Bae EJ, Bandyopadhyay G, Oliver J, Marathe C, Chen M, Hsu JY, Chen Y, Tian H, Olefsky J, Saberi M. Restoration of euglycemia after duodenal bypass surgery is reliant on central and peripheral inputs in Zucker fa/fa rats. Diabetes. 2013 Apr; 62(4):1074-83. PMID: 23248171; PMCID: PMC3609588.
    38. Qatanani M, Tan Y, Dobrin R, Greenawalt DM, Hu G, Zhao W, Olefsky J, Sears DD, Kaplan LM, Kemp DM. Inverse regulation of inflammation and mitochondrial function in adipose tissue defines extreme insulin sensitivity in morbidly obese patients. Diabetes. 2013 Mar; 62(3):855-63. PMID: 23223024; PMCID: PMC3581230.
    39. Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M. Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 2012 Sep 05; 16(3):311-21. PMID: 22958918; PMCID: PMC3687365.
    40. Talukdar S, Oh DY, Bandyopadhyay G, Li D, Xu J, McNelis J, Lu M, Li P, Yan Q, Zhu Y, Ofrecio J, Lin M, Brenner MB, Olefsky J. Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nat Med. 2012 Sep; 18(9):1407-12. PMID: 22863787; PMCID: PMC3491143.
    41. Heinrichsdorff J, Olefsky J. Fetuin-A: the missing link in lipid-induced inflammation. Nat Med. 2012 Aug; 18(8):1182-3. PMID: 22869185.
      View in: PubMed
    42. Xu J, Morinaga H, Oh D, Li P, Chen A, Talukdar S, Mamane Y, Mancini JA, Nawrocki AR, Lazarowski E, Olefsky J, Kim JJ. GPR105 ablation prevents inflammation and improves insulin sensitivity in mice with diet-induced obesity. J Immunol. 2012 Aug 15; 189(4):1992-9. PMID: 22778393; PMCID: PMC3411902.
    43. Osborn O, Oh DY, McNelis J, Sanchez-Alavez M, Talukdar S, Lu M, Li P, Thiede L, Morinaga H, Kim JJ, Heinrichsdorff J, Nalbandian S, Ofrecio JM, Scadeng M, Schenk S, Hadcock J, Bartfai T, Olefsky J. G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice. J Clin Invest. 2012 Jul; 122(7):2444-53. PMID: 22653059; PMCID: PMC3386820.
    44. Jonker JW, Suh JM, Atkins AR, Ahmadian M, Li P, Whyte J, He M, Juguilon H, Yin YQ, Phillips CT, Yu RT, Olefsky J, Henry RR, Downes M, Evans RM. A PPAR?-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis. Nature. 2012 May 17; 485(7398):391-4. PMID: 22522926; PMCID: PMC3358516.
    45. Oh DY, Olefsky J. Omega 3 fatty acids and GPR120. Cell Metab. 2012 May 02; 15(5):564-5. PMID: 22560206; PMCID: PMC3803996.
    46. Glass CK, Olefsky J. Inflammation and lipid signaling in the etiology of insulin resistance. Cell Metab. 2012 May 02; 15(5):635-45. PMID: 22560216; PMCID: PMC4156155.
    47. Kim JJ, Fan W, Olefsky J. Putting the brakes on FOXO1 in fat. EMBO J. 2012 May 16; 31(10):2240-1. PMID: 22510885; PMCID: PMC3364738.
    48. Bae EJ, Xu J, Oh DY, Bandyopadhyay G, Lagakos WS, Keshwani M, Olefsky J. Liver-specific p70 S6 kinase depletion protects against hepatic steatosis and systemic insulin resistance. J Biol Chem. 2012 May 25; 287(22):18769-80. PMID: 22493495; PMCID: PMC3365775.
    49. Baeza-Raja B, Li P, Le Moan N, Sachs BD, Schachtrup C, Davalos D, Vagena E, Bridges D, Kim C, Saltiel AR, Olefsky J, Akassoglou K. p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. Proc Natl Acad Sci U S A. 2012 Apr 10; 109(15):5838-43. PMID: 22460790; PMCID: PMC3326459.
    50. Osborn O, Olefsky J. The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med. 2012 Mar 06; 18(3):363-74. PMID: 22395709.
      View in: PubMed
    51. Oh DY, Morinaga H, Talukdar S, Bae EJ, Olefsky J. Increased macrophage migration into adipose tissue in obese mice. Diabetes. 2012 Feb; 61(2):346-54. PMID: 22190646; PMCID: PMC3266418.
    52. Gillum MP, Kotas ME, Erion DM, Kursawe R, Chatterjee P, Nead KT, Muise ES, Hsiao JJ, Frederick DW, Yonemitsu S, Banks AS, Qiang L, Bhanot S, Olefsky J, Sears DD, Caprio S, Shulman GI. SirT1 regulates adipose tissue inflammation. Diabetes. 2011 Dec; 60(12):3235-45. PMID: 22110092; PMCID: PMC3219953.
    53. Li P, Fan W, Xu J, Lu M, Yamamoto H, Auwerx J, Sears DD, Talukdar S, Oh D, Chen A, Bandyopadhyay G, Scadeng M, Ofrecio JM, Nalbandian S, Olefsky J. Adipocyte NCoR knockout decreases PPAR? phosphorylation and enhances PPAR? activity and insulin sensitivity. Cell. 2011 Nov 11; 147(4):815-26. PMID: 22078880; PMCID: PMC3783197.
    54. Schenk S, McCurdy CE, Philp A, Chen MZ, Holliday MJ, Bandyopadhyay GK, Osborn O, Baar K, Olefsky J. Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. J Clin Invest. 2011 Nov; 121(11):4281-8. PMID: 21985785; PMCID: PMC3204844.
    55. Lee YS, Li P, Huh JY, Hwang IJ, Lu M, Kim JI, Ham M, Talukdar S, Chen A, Lu WJ, Bandyopadhyay GK, Schwendener R, Olefsky J, Kim JB. Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance. Diabetes. 2011 Oct; 60(10):2474-83. PMID: 21911747; PMCID: PMC3178297.
    56. Ohtsubo K, Chen MZ, Olefsky J, Marth JD. Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport. Nat Med. 2011 Aug 14; 17(9):1067-75. PMID: 21841783; PMCID: PMC3888087.
    57. Talukdar S, Olefsky J, Osborn O. Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases. Trends Pharmacol Sci. 2011 Sep; 32(9):543-50. PMID: 21663979; PMCID: PMC3419590.
    58. Lan D, Lu M, Sharma S, Mellon PL, Olefsky J, Webster NJ. Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHß gene expression by a SirT1-independent pathway in LßT2 gonadotrope cells. Reprod Toxicol. 2011 Jul; 32(1):85-92. PMID: 21679764; PMCID: PMC3155991.
    59. Lu M, Sarruf DA, Talukdar S, Sharma S, Li P, Bandyopadhyay G, Nalbandian S, Fan W, Gayen JR, Mahata SK, Webster NJ, Schwartz MW, Olefsky J. Brain PPAR-? promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones. Nat Med. 2011 May; 17(5):618-22. PMID: 21532596; PMCID: PMC3380629.
    60. Osawa Y, Seki E, Kodama Y, Suetsugu A, Miura K, Adachi M, Ito H, Shiratori Y, Banno Y, Olefsky J, Nagaki M, Moriwaki H, Brenner DA, Seishima M. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. FASEB J. 2011 Apr; 25(4):1133-44. PMID: 21163859; PMCID: PMC3058702.
    61. Osborn O, Sears DD, Olefsky J. Fat-induced inflammation unchecked. Cell Metab. 2010 Dec 01; 12(6):553-4. PMID: 21109185.
      View in: PubMed
    62. Sharma S, Sharma PM, Mistry DS, Chang RJ, Olefsky J, Mellon PL, Webster NJ. PPARG regulates gonadotropin-releasing hormone signaling in LbetaT2 cells in vitro and pituitary gonadotroph function in vivo in mice. Biol Reprod. 2011 Mar; 84(3):466-75. PMID: 21076077; PMCID: PMC3043129.
    63. Fan W, Morinaga H, Kim JJ, Bae E, Spann NJ, Heinz S, Glass CK, Olefsky J. FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages. EMBO J. 2010 Dec 15; 29(24):4223-36. PMID: 21045807; PMCID: PMC3018786.
    64. Oh DY, Talukdar S, Bae EJ, Imamura T, Morinaga H, Fan W, Li P, Lu WJ, Watkins SM, Olefsky J. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell. 2010 Sep 03; 142(5):687-98. PMID: 20813258; PMCID: PMC2956412.
    65. Oh DY, Olefsky J. Medicine. Wnt fans the flames in obesity. Science. 2010 Jul 23; 329(5990):397-8. PMID: 20651140.
      View in: PubMed
    66. Lu M, Li P, Pferdekamper J, Fan W, Saberi M, Schenk S, Olefsky J. Inducible nitric oxide synthase deficiency in myeloid cells does not prevent diet-induced insulin resistance. Mol Endocrinol. 2010 Jul; 24(7):1413-22. PMID: 20444886; PMCID: PMC2903908.
    67. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H, Olefsky J, Brenner DA, Seki E. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology. 2010 Jul; 139(1):323-34.e7. PMID: 20347818; PMCID: PMC4631262.
    68. Li P, Lu M, Nguyen MT, Bae EJ, Chapman J, Feng D, Hawkins M, Pessin JE, Sears DD, Nguyen AK, Amidi A, Watkins SM, Nguyen U, Olefsky J. Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. J Biol Chem. 2010 May 14; 285(20):15333-45. PMID: 20308074; PMCID: PMC2865288.
    69. Lu M, Patsouris D, Li P, Flores-Riveros J, Frincke JM, Watkins S, Schenk S, Olefsky J. A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats. Am J Physiol Endocrinol Metab. 2010 May; 298(5):E1036-48. PMID: 20159859; PMCID: PMC2867370.
    70. Wang T, Villegas S, Huang Y, White SK, Ahlem C, Lu M, Olefsky J, Reading C, Frincke JM, Alleva D, Flores-Riveros J. Amelioration of glucose intolerance by the synthetic androstene HE3286: link to inflammatory pathways. J Pharmacol Exp Ther. 2010 Apr; 333(1):70-80. PMID: 20068030.
      View in: PubMed
    71. Olefsky J, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol. 2010; 72:219-46. PMID: 20148674.
      View in: PubMed
    72. Sugii S, Olson P, Sears DD, Saberi M, Atkins AR, Barish GD, Hong SH, Castro GL, Yin YQ, Nelson MC, Hsiao G, Greaves DR, Downes M, Yu RT, Olefsky J, Evans RM. PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22504-9. PMID: 20018750.
      View in: PubMed
    73. Yoshizaki T, Schenk S, Imamura T, Babendure JL, Sonoda N, Bae EJ, Oh DY, Lu M, Milne JC, Westphal C, Bandyopadhyay G, Olefsky J. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab. 2010 Mar; 298(3):E419-28. PMID: 19996381; PMCID: PMC2838524.
    74. Saberi M, Woods NB, de Luca C, Schenk S, Lu JC, Bandyopadhyay G, Verma IM, Olefsky J. Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab. 2009 Nov; 10(5):419-29. PMID: 19883619; PMCID: PMC2790319.
    75. Patsouris D, Neels JG, Fan W, Li PP, Nguyen MT, Olefsky J. Glucocorticoids and thiazolidinediones interfere with adipocyte-mediated macrophage chemotaxis and recruitment. J Biol Chem. 2009 Nov 06; 284(45):31223-35. PMID: 19740750; PMCID: PMC2781521.
    76. Olefsky J. IKKepsilon: a bridge between obesity and inflammation. Cell. 2009 Sep 04; 138(5):834-6. PMID: 19737512.
      View in: PubMed
    77. Saberi M, Bjelica D, Schenk S, Imamura T, Bandyopadhyay G, Li P, Jadhar V, Vargeese C, Wang W, Bowman K, Zhang Y, Polisky B, Olefsky J. Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes. Am J Physiol Endocrinol Metab. 2009 Nov; 297(5):E1137-46. PMID: 19706791.
      View in: PubMed
    78. Kim JJ, Li P, Huntley J, Chang JP, Arden KC, Olefsky J. FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue. Diabetes. 2009 Jun; 58(6):1275-82. PMID: 19289458; PMCID: PMC2682681.
    79. Vu CB, Bemis JE, Disch JS, Ng PY, Nunes JJ, Milne JC, Carney DP, Lynch AV, Smith JJ, Lavu S, Lambert PD, Gagne DJ, Jirousek MR, Schenk S, Olefsky J, Perni RB. Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators. J Med Chem. 2009 Mar 12; 52(5):1275-83. PMID: 19199480.
      View in: PubMed
    80. Fan W, Imamura T, Sonoda N, Sears DD, Patsouris D, Kim JJ, Olefsky J. FOXO1 transrepresses peroxisome proliferator-activated receptor gamma transactivation, coordinating an insulin-induced feed-forward response in adipocytes. J Biol Chem. 2009 May 01; 284(18):12188-97. PMID: 19246449; PMCID: PMC2673287.
    81. Yoshizaki T, Milne JC, Imamura T, Schenk S, Sonoda N, Babendure JL, Lu JC, Smith JJ, Jirousek MR, Olefsky J. SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Mol Cell Biol. 2009 Mar; 29(5):1363-74. PMID: 19103747; PMCID: PMC2643824.
    82. Nofsinger RR, Li P, Hong SH, Jonker JW, Barish GD, Ying H, Cheng SY, Leblanc M, Xu W, Pei L, Kang YJ, Nelson M, Downes M, Yu RT, Olefsky J, Lee CH, Evans RM. SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):20021-6. PMID: 19066220; PMCID: PMC2598729.
    83. Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates J, Olefsky J, Guarente L, Montminy M. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature. 2008 Nov 13; 456(7219):269-73. PMID: 18849969; PMCID: PMC2597669.
    84. Patsouris D, Li PP, Thapar D, Chapman J, Olefsky J, Neels JG. Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab. 2008 Oct; 8(4):301-9. PMID: 18840360; PMCID: PMC2630775.
    85. Olefsky J. Fat talks, liver and muscle listen. Cell. 2008 Sep 19; 134(6):914-6. PMID: 18805083.
      View in: PubMed
    86. Schenk S, Saberi M, Olefsky J. Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest. 2008 Sep; 118(9):2992-3002. PMID: 18769626; PMCID: PMC2522344.
    87. Sonoda N, Imamura T, Yoshizaki T, Babendure JL, Lu JC, Olefsky J. Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cells. Proc Natl Acad Sci U S A. 2008 May 06; 105(18):6614-9. PMID: 18445652; PMCID: PMC2373360.
    88. Féral CC, Neels JG, Kummer C, Slepak M, Olefsky J, Ginsberg MH. Blockade of alpha4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesity. Diabetes. 2008 Jul; 57(7):1842-51. PMID: 18426864; PMCID: PMC2453617.
    89. Yang X, Ongusaha PP, Miles PD, Havstad JC, Zhang F, So WV, Kudlow JE, Michell RH, Olefsky J, Field SJ, Evans RM. Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. Nature. 2008 Feb 21; 451(7181):964-9. PMID: 18288188.
      View in: PubMed
    90. de Luca C, Olefsky J. Inflammation and insulin resistance. FEBS Lett. 2008 Jan 09; 582(1):97-105. PMID: 18053812; PMCID: PMC2246086.
    91. Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky J, Jirousek MR, Elliott PJ, Westphal CH. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29; 450(7170):712-6. PMID: 18046409; PMCID: PMC2753457.
    92. Lu M, Tang Q, Olefsky J, Mellon PL, Webster NJ. Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes. Mol Endocrinol. 2008 Mar; 22(3):760-71. PMID: 18006641; PMCID: PMC2262174.
    93. Solinas G, Vilcu C, Neels JG, Bandyopadhyay GK, Luo JL, Naugler W, Grivennikov S, Wynshaw-Boris A, Scadeng M, Olefsky J, Karin M. JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab. 2007 Nov; 6(5):386-97. PMID: 17983584.
      View in: PubMed
    94. Sears DD, Hsiao A, Ofrecio JM, Chapman J, He W, Olefsky J. Selective modulation of promoter recruitment and transcriptional activity of PPARgamma. Biochem Biophys Res Commun. 2007 Dec 21; 364(3):515-21. PMID: 17963725; PMCID: PMC2585742.
    95. Nguyen MT, Favelyukis S, Nguyen AK, Reichart D, Scott PA, Jenn A, Liu-Bryan R, Glass CK, Neels JG, Olefsky J. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem. 2007 Nov 30; 282(48):35279-92. PMID: 17916553.
      View in: PubMed
    96. Kawamata Y, Imamura T, Babendure JL, Lu JC, Yoshizaki T, Olefsky J. Tumor necrosis factor receptor-1 can function through a G alpha q/11-beta-arrestin-1 signaling complex. J Biol Chem. 2007 Sep 28; 282(39):28549-56. PMID: 17664271.
      View in: PubMed
    97. Hevener AL, Olefsky J, Reichart D, Nguyen MT, Bandyopadyhay G, Leung HY, Watt MJ, Benner C, Febbraio MA, Nguyen AK, Folian B, Subramaniam S, Gonzalez FJ, Glass CK, Ricote M. Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest. 2007 Jun; 117(6):1658-69. PMID: 17525798; PMCID: PMC1868788.
    98. Yoshizaki T, Imamura T, Babendure JL, Lu JC, Sonoda N, Olefsky J. Myosin 5a is an insulin-stimulated Akt2 (protein kinase Bbeta) substrate modulating GLUT4 vesicle translocation. Mol Cell Biol. 2007 Jul; 27(14):5172-83. PMID: 17515613; PMCID: PMC1951956.
    99. Liao W, Nguyen MT, Yoshizaki T, Favelyukis S, Patsouris D, Imamura T, Verma IM, Olefsky J. Suppression of PPAR-gamma attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab. 2007 Jul; 293(1):E219-27. PMID: 17389706.
      View in: PubMed
    100. Miles PD, Treuner K, Latronica M, Olefsky J, Barlow C. Impaired insulin secretion in a mouse model of ataxia telangiectasia. Am J Physiol Endocrinol Metab. 2007 Jul; 293(1):E70-4. PMID: 17356010.
      View in: PubMed
    101. Lesniewski LA, Hosch SE, Neels JG, de Luca C, Pashmforoush M, Lumeng CN, Chiang SH, Scadeng M, Saltiel AR, Olefsky J. Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance. Nat Med. 2007 Apr; 13(4):455-62. PMID: 17351624.
      View in: PubMed
    102. Hupfeld CJ, Olefsky J. Regulation of receptor tyrosine kinase signaling by GRKs and beta-arrestins. Annu Rev Physiol. 2007; 69:561-77. PMID: 17002595.
      View in: PubMed
    103. Olefsky J. The US's changing competitiveness in the biomedical sciences. J Clin Invest. 2007 Jan; 117(1):270-6. PMID: 17200723; PMCID: PMC1751294.
    104. Bandyopadhyay GK, Yu JG, Ofrecio J, Olefsky J. Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects. Diabetes. 2006 Aug; 55(8):2277-85. PMID: 16873691.
      View in: PubMed
    105. Hosch SE, Olefsky J, Kim JJ. APPLied mechanics: uncovering how adiponectin modulates insulin action. Cell Metab. 2006 Jul; 4(1):5-6. PMID: 16814726.
      View in: PubMed
    106. Neels JG, Olefsky J. Cell signaling. A new way to burn fat. Science. 2006 Jun 23; 312(5781):1756-8. PMID: 16794069.
      View in: PubMed
    107. Liao W, Nguyen MT, Imamura T, Singer O, Verma IM, Olefsky J. Lentiviral short hairpin ribonucleic acid-mediated knockdown of GLUT4 in 3T3-L1 adipocytes. Endocrinology. 2006 May; 147(5):2245-52. PMID: 16497797.
      View in: PubMed
    108. Lee CH, Olson P, Hevener A, Mehl I, Chong LW, Olefsky J, Gonzalez FJ, Ham J, Kang H, Peters JM, Evans RM. PPARdelta regulates glucose metabolism and insulin sensitivity. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3444-9. PMID: 16492734; PMCID: PMC1413918.
    109. Shin SY, Bahk YY, Ko J, Chung IY, Lee YS, Downward J, Eibel H, Sharma PM, Olefsky J, Kim YH, Lee B, Lee YH. Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras. EMBO J. 2006 Mar 08; 25(5):1093-103. PMID: 16456537; PMCID: PMC1409727.
    110. Neels JG, Olefsky J. Inflamed fat: what starts the fire? J Clin Invest. 2006 Jan; 116(1):33-5. PMID: 16395402; PMCID: PMC1323268.
    111. de Luca C, Olefsky J. Stressed out about obesity and insulin resistance. Nat Med. 2006 Jan; 12(1):41-2; discussion 42. PMID: 16397561.
      View in: PubMed
    112. Huang J, Imamura T, Babendure JL, Lu JC, Olefsky J. Disruption of microtubules ablates the specificity of insulin signaling to GLUT4 translocation in 3T3-L1 adipocytes. J Biol Chem. 2005 Dec 23; 280(51):42300-6. PMID: 16239226.
      View in: PubMed
    113. Zhang J, Hupfeld CJ, Taylor SS, Olefsky J, Tsien RY. Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature. 2005 Sep 22; 437(7058):569-73. PMID: 16177793.
      View in: PubMed
    114. Li LS, Babendure JL, Sinha SC, Olefsky J, Lerner RA. Synthesis and evaluation of photolabile insulin prodrugs. Bioorg Med Chem Lett. 2005 Sep 01; 15(17):3917-20. PMID: 15993597.
      View in: PubMed
    115. Nguyen MT, Satoh H, Favelyukis S, Babendure JL, Imamura T, Sbodio JI, Zalevsky J, Dahiyat BI, Chi NW, Olefsky J. JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. J Biol Chem. 2005 Oct 21; 280(42):35361-71. PMID: 16085647.
      View in: PubMed
    116. Wilkes JJ, Nguyen MT, Bandyopadhyay GK, Nelson E, Olefsky J. Topiramate treatment causes skeletal muscle insulin sensitization and increased Acrp30 secretion in high-fat-fed male Wistar rats. Am J Physiol Endocrinol Metab. 2005 Dec; 289(6):E1015-22. PMID: 16030065.
      View in: PubMed
    117. Hsiao A, Ideker T, Olefsky J, Subramaniam S. VAMPIRE microarray suite: a web-based platform for the interpretation of gene expression data. Nucleic Acids Res. 2005 Jul 01; 33(Web Server issue):W627-32. PMID: 15980550; PMCID: PMC1160204.
    118. Usui I, Imamura T, Babendure JL, Satoh H, Lu JC, Hupfeld CJ, Olefsky J. G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes. Mol Endocrinol. 2005 Nov; 19(11):2760-8. PMID: 15994203.
      View in: PubMed
    119. Satoh H, Nguyen MT, Trujillo M, Imamura T, Usui I, Scherer PE, Olefsky J. Adenovirus-mediated adiponectin expression augments skeletal muscle insulin sensitivity in male Wistar rats. Diabetes. 2005 May; 54(5):1304-13. PMID: 15855314.
      View in: PubMed
    120. Bard-Chapeau EA, Hevener AL, Long S, Zhang EE, Olefsky J, Feng GS. Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action. Nat Med. 2005 May; 11(5):567-71. PMID: 15821749.
      View in: PubMed
    121. Goodarzi MO, Taylor KD, Guo X, Quiñones MJ, Cui J, Li X, Hang T, Yang H, Holmes E, Hsueh WA, Olefsky J, Rotter JI. Variation in the gene for muscle-specific AMP deaminase is associated with insulin clearance, a highly heritable trait. Diabetes. 2005 Apr; 54(4):1222-7. PMID: 15793265.
      View in: PubMed
    122. Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med. 2005 Feb; 11(2):191-8. PMID: 15685170.
      View in: PubMed
    123. Wilkes JJ, Nelson E, Osborne M, Demarest KT, Olefsky J. Topiramate is an insulin-sensitizing compound in vivo with direct effects on adipocytes in female ZDF rats. Am J Physiol Endocrinol Metab. 2005 Mar; 288(3):E617-24. PMID: 15536205.
      View in: PubMed
    124. Hupfeld CJ, Resnik JL, Ugi S, Olefsky J. Insulin-induced beta-arrestin1 Ser-412 phosphorylation is a mechanism for desensitization of ERK activation by Galphai-coupled receptors. J Biol Chem. 2005 Jan 14; 280(2):1016-23. PMID: 15520010.
      View in: PubMed
    125. Sharma PM, Son HS, Ugi S, Ricketts W, Olefsky J. Mechanism of SHIP-mediated inhibition of insulin- and platelet-derived growth factor-stimulated mitogen-activated protein kinase activity in 3T3-L1 adipocytes. Mol Endocrinol. 2005 Feb; 19(2):421-30. PMID: 15486046.
      View in: PubMed
    126. Usui I, Imamura T, Huang J, Satoh H, Shenoy SK, Lefkowitz RJ, Hupfeld CJ, Olefsky J. beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1. Mol Cell Biol. 2004 Oct; 24(20):8929-37. PMID: 15456867; PMCID: PMC517874.
    127. Ugi S, Imamura T, Maegawa H, Egawa K, Yoshizaki T, Shi K, Obata T, Ebina Y, Kashiwagi A, Olefsky J. Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes. Mol Cell Biol. 2004 Oct; 24(19):8778-89. PMID: 15367694; PMCID: PMC516764.
    128. Wiedmer T, Zhao J, Li L, Zhou Q, Hevener A, Olefsky J, Curtiss LK, Sims PJ. Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3). Proc Natl Acad Sci U S A. 2004 Sep 07; 101(36):13296-301. PMID: 15328404; PMCID: PMC516563.
    129. Usui I, Imamura T, Satoh H, Huang J, Babendure JL, Hupfeld CJ, Olefsky J. GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation. EMBO J. 2004 Jul 21; 23(14):2821-9. PMID: 15241473; PMCID: PMC514955.
    130. Satoh H, Nguyen MT, Miles PD, Imamura T, Usui I, Olefsky J. Adenovirus-mediated chronic "hyper-resistinemia" leads to in vivo insulin resistance in normal rats. J Clin Invest. 2004 Jul; 114(2):224-31. PMID: 15254589; PMCID: PMC449745.
    131. Koo SH, Satoh H, Herzig S, Lee CH, Hedrick S, Kulkarni R, Evans RM, Olefsky J, Montminy M. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat Med. 2004 May; 10(5):530-4. PMID: 15107844.
      View in: PubMed
    132. Yoshizaki T, Maegawa H, Egawa K, Ugi S, Nishio Y, Imamura T, Kobayashi T, Tamura S, Olefsky J, Kashiwagi A. Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. J Biol Chem. 2004 May 21; 279(21):22715-26. PMID: 15016818.
      View in: PubMed
    133. Huang J, Hsia SH, Imamura T, Usui I, Olefsky J. Annexin II is a thiazolidinedione-responsive gene involved in insulin-induced glucose transporter isoform 4 translocation in 3T3-L1 adipocytes. Endocrinology. 2004 Apr; 145(4):1579-86. PMID: 14726447.
      View in: PubMed
    134. Pillay TS, Xiao S, Keranen L, Olefsky J. Regulation of the insulin receptor by protein kinase C isoenzymes: preferential interaction with beta isoenzymes and interaction with the catalytic domain of betaII. Cell Signal. 2004 Jan; 16(1):97-104. PMID: 14607280.
      View in: PubMed
    135. Pajvani UB, Hawkins M, Combs TP, Rajala MW, Doebber T, Berger JP, Wagner JA, Wu M, Knopps A, Xiang AH, Utzschneider KM, Kahn SE, Olefsky J, Buchanan TA, Scherer PE. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem. 2004 Mar 26; 279(13):12152-62. PMID: 14699128.
      View in: PubMed
    136. He W, Barak Y, Hevener A, Olson P, Liao D, Le J, Nelson M, Ong E, Olefsky J, Evans RM. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15712-7. PMID: 14660788; PMCID: PMC307633.
    137. Hevener AL, He W, Barak Y, Le J, Bandyopadhyay G, Olson P, Wilkes J, Evans RM, Olefsky J. Muscle-specific Pparg deletion causes insulin resistance. Nat Med. 2003 Dec; 9(12):1491-7. PMID: 14625542.
      View in: PubMed
    138. Xie L, Lee SY, Andersen JN, Waters S, Shen K, Guo XL, Moller NP, Olefsky J, Lawrence DS, Zhang ZY. Cellular effects of small molecule PTP1B inhibitors on insulin signaling. Biochemistry. 2003 Nov 11; 42(44):12792-804. PMID: 14596593.
      View in: PubMed
    139. Wilkes JJ, Hevener A, Olefsky J. Chronic endothelin-1 treatment leads to insulin resistance in vivo. Diabetes. 2003 Aug; 52(8):1904-9. PMID: 12882904.
      View in: PubMed
    140. Imamura T, Huang J, Usui I, Satoh H, Bever J, Olefsky J. Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin. Mol Cell Biol. 2003 Jul; 23(14):4892-900. PMID: 12832475; PMCID: PMC162221.
    141. Yu JG, Boies SM, Olefsky J. The effect of oral glucosamine sulfate on insulin sensitivity in human subjects. Diabetes Care. 2003 Jun; 26(6):1941-2. PMID: 12766141.
      View in: PubMed
    142. Lee B, Miles PD, Vargas L, Luan P, Glasco S, Kushnareva Y, Kornbrust ES, Grako KA, Wollheim CB, Maechler P, Olefsky J, Anderson CM. Inhibition of mitochondrial Na+-Ca2+ exchanger increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets. Diabetes. 2003 Apr; 52(4):965-73. PMID: 12663468.
      View in: PubMed
    143. Miles PD, Barak Y, Evans RM, Olefsky J. Effect of heterozygous PPARgamma deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding. Am J Physiol Endocrinol Metab. 2003 Mar; 284(3):E618-26. PMID: 12556354.
      View in: PubMed
    144. Usui I, Imamura T, Huang J, Satoh H, Olefsky J. Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3T3-L1 adipocytes. J Biol Chem. 2003 Apr 18; 278(16):13765-74. PMID: 12566459.
      View in: PubMed
    145. Kruszynska YT, Olefsky J, Frias JP. Effect of obesity on susceptibility to fatty acid-induced peripheral tissue insulin resistance. Metabolism. 2003 Feb; 52(2):233-8. PMID: 12601639.
      View in: PubMed
    146. Hupfeld CJ, Dalle S, Olefsky J. Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A. 2003 Jan 07; 100(1):161-6. PMID: 12509508; PMCID: PMC140914.
    147. Ruan H, Miles PD, Ladd CM, Ross K, Golub TR, Olefsky J, Lodish HF. Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistance. Diabetes. 2002 Nov; 51(11):3176-88. PMID: 12401708.
      View in: PubMed
    148. Yu JG, Javorschi S, Hevener AL, Kruszynska YT, Norman RA, Sinha M, Olefsky J. The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. Diabetes. 2002 Oct; 51(10):2968-74. PMID: 12351435.
      View in: PubMed
    149. Dalle S, Imamura T, Rose DW, Worrall DS, Ugi S, Hupfeld CJ, Olefsky J. Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1. Mol Cell Biol. 2002 Sep; 22(17):6272-85. PMID: 12167719; PMCID: PMC134007.
    150. Liu F, Usui I, Evans LG, Austin DA, Mellon PL, Olefsky J, Webster NJ. Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells. J Biol Chem. 2002 Aug 30; 277(35):32099-108. PMID: 12050161; PMCID: PMC2930616.
    151. Hevener A, Reichart D, Janez A, Olefsky J. Female rats do not exhibit free fatty acid-induced insulin resistance. Diabetes. 2002 Jun; 51(6):1907-12. PMID: 12031980.
      View in: PubMed
    152. Herrnstadt C, Elson JL, Fahy E, Preston G, Turnbull DM, Anderson C, Ghosh SS, Olefsky J, Beal MF, Davis RE, Howell N. Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups. Am J Hum Genet. 2002 May; 70(5):1152-71. PMID: 11938495; PMCID: PMC447592.
    153. Ugi S, Imamura T, Ricketts W, Olefsky J. Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling. Mol Cell Biol. 2002 Apr; 22(7):2375-87. PMID: 11884620; PMCID: PMC133677.
    154. Ugi S, Sharma PM, Ricketts W, Imamura T, Olefsky J. Phosphatidylinositol 3-kinase is required for insulin-stimulated tyrosine phosphorylation of Shc in 3T3-L1 adipocytes. J Biol Chem. 2002 May 24; 277(21):18592-7. PMID: 11897789.
      View in: PubMed
    155. Liu F, Austin DA, Mellon PL, Olefsky J, Webster NJ. GnRH activates ERK1/2 leading to the induction of c-fos and LHbeta protein expression in LbetaT2 cells. Mol Endocrinol. 2002 Mar; 16(3):419-34. PMID: 11875099.
      View in: PubMed
    156. Worrall DS, Olefsky J. The effects of intracellular calcium depletion on insulin signaling in 3T3-L1 adipocytes. Mol Endocrinol. 2002 Feb; 16(2):378-89. PMID: 11818508.
      View in: PubMed
    157. Kruszynska YT, Worrall DS, Ofrecio J, Frias JP, Macaraeg G, Olefsky J. Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation. J Clin Endocrinol Metab. 2002 Jan; 87(1):226-34. PMID: 11788651.
      View in: PubMed
    158. Barak Y, Liao D, He W, Ong ES, Nelson MC, Olefsky J, Boland R, Evans RM. Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):303-8. PMID: 11756685; PMCID: PMC117556.
    159. Olefsky J. Nuclear receptor minireview series. J Biol Chem. 2001 Oct 05; 276(40):36863-4. PMID: 11459855.
      View in: PubMed
    160. Olefsky J. Prospects for research in diabetes mellitus. JAMA. 2001 Feb 07; 285(5):628-32. PMID: 11176871.
      View in: PubMed
    161. Olefsky J. Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists. J Clin Invest. 2000 Aug; 106(4):467-72. PMID: 10953021; PMCID: PMC380259.
    Jerrold's Networks
    Concepts
    Derived automatically from this person's publications.
    _
    Co-Authors
    People in Profiles who have published with this person.
    _
    Related Authors
    People who share related concepts with this person.
    _