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Paul Jensen

TitleResearcher
InstitutionUniversity of California San Diego
DepartmentCenter for Marine Biotechnology and Biomedecine
Address9500 Gilman Drive #0204
La Jolla CA 92093
Phone858-534-7322
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    Collapse Research 
    Collapse Research Activities and Funding
    2018 Marine Natural Products Gordon Research Conference & Gordon Research Seminar
    NIH/NCCIH R13AT009815Dec 1, 2017 - Nov 30, 2018
    Role: Principal Investigator
    Scripps Center for Ocean and Human Health
    NIH/NIEHS P01ES021921Sep 24, 2012 - Jul 31, 2017
    Role: Co-Investigator
    A sequenced-based approach for improved small molecule discovery
    NIH/NIGMS R01GM086261Aug 1, 2010 - May 31, 2014
    Role: Principal Investigator
    Natural Product Genome Mining
    NIH/NIGMS R01GM085770Aug 1, 2009 - Jul 31, 2021
    Role: Principal Investigator
    Exploration, conservation, & development of marine biodiversity in Fiji and the S
    NIH U19TW007401Sep 29, 2005 - Jul 31, 2019
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kim MC, Machado HA, Jang KH, Trzoss L, Jensen PR, Fenical W. Integration of Genomic Data with NMR Analysis Enables Assignment of the Full Stereostructure of Neaumycin B, a Potent Inhibitor of Glioblastoma from a Marine-Derived Micromonospora. J Am Chem Soc. 2018 Aug 07. PMID: 30085661.
      View in: PubMed
    2. Patin NV, Floros DJ, Hughes CC, Dorrestein PC, Jensen PR. The role of inter-species interactions in Salinispora specialized metabolism. Microbiology. 2018 Jun 07. PMID: 29877785.
      View in: PubMed
    3. Amos GCA, Awakawa T, Tuttle RN, Letzel AC, Kim MC, Kudo Y, Fenical W, Moore BS, Jensen PR. Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality. Proc Natl Acad Sci U S A. 2017 12 26; 114(52):E11121-E11130. PMID: 29229817.
      View in: PubMed
    4. Machado H, Tuttle RN, Jensen PR. Omics-based natural product discovery and the lexicon of genome mining. Curr Opin Microbiol. 2017 Oct; 39:136-142. PMID: 29175703.
      View in: PubMed
    5. Bruns H, Crüsemann M, Letzel AC, Alanjary M, McInerney JO, Jensen PR, Schulz S, Moore BS, Ziemert N. Function-related replacement of bacterial siderophore pathways. ISME J. 2018 Feb; 12(2):320-329. PMID: 28809850.
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    6. Letzel AC, Li J, Amos GCA, Millán-Aguiñaga N, Ginigini J, Abdelmohsen UR, Gaudêncio SP, Ziemert N, Moore BS, Jensen PR. Genomic insights into specialized metabolism in the marine actinomycete Salinispora. Environ Microbiol. 2017 Sep; 19(9):3660-3673. PMID: 28752948.
      View in: PubMed
    7. Millán-Aguiñaga N, Chavarria KL, Ugalde JA, Letzel AC, Rouse GW, Jensen PR. Phylogenomic Insight into Salinispora (Bacteria, Actinobacteria) Species Designations. Sci Rep. 2017 Jun 15; 7(1):3564. PMID: 28620214.
      View in: PubMed
    8. Gallagher KA, Wanger G, Henderson J, Llorente M, Hughes CC, Jensen PR. Ecological implications of hypoxia-triggered shifts in secondary metabolism. Environ Microbiol. 2017 Jun; 19(6):2182-2191. PMID: 28205416.
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    9. Agarwal V, Blanton JM, Podell S, Taton A, Schorn MA, Busch J, Lin Z, Schmidt EW, Jensen PR, Paul VJ, Biggs JS, Golden JW, Allen EE, Moore BS. Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges. Nat Chem Biol. 2017 05; 13(5):537-543. PMID: 28319100.
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    10. Asolkar RN, Singh A, Jensen PR, Aalbersberg W, Carté BK, Feussner KD, Subramani R, DiPasquale A, Rheingold AL, Fenical W. Marinocyanins, cytotoxic bromo-phenazinone meroterpenoids from a marine bacterium from the streptomycete clade MAR4. Tetrahedron. 2017 Apr 20; 73(16):2234-2241. PMID: 28814819.
      View in: PubMed
    11. Patin NV, Schorn M, Aguinaldo K, Lincecum T, Moore BS, Jensen PR. Effects of Actinomycete Secondary Metabolites on Sediment Microbial Communities. Appl Environ Microbiol. 2017 Feb 15; 83(4). PMID: 27986719.
      View in: PubMed
    12. Crüsemann M, O'Neill EC, Larson CB, Melnik AV, Floros DJ, da Silva RR, Jensen PR, Dorrestein PC, Moore BS. Prioritizing Natural Product Diversity in a Collection of 146 Bacterial Strains Based on Growth and Extraction Protocols. J Nat Prod. 2017 Mar 24; 80(3):588-597. PMID: 28335604.
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    13. Schorn MA, Alanjary MM, Aguinaldo K, Korobeynikov A, Podell S, Patin N, Lincecum T, Jensen PR, Ziemert N, Moore BS. Sequencing rare marine actinomycete genomes reveals high density of unique natural product biosynthetic gene clusters. Microbiology. 2016 12; 162(12):2075-2086. PMID: 27902408.
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    14. Floros DJ, Jensen PR, Dorrestein PC, Koyama N. A metabolomics guided exploration of marine natural product chemical space. Metabolomics. 2016 Sep; 12(9). PMID: 28819353.
      View in: PubMed
    15. Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, P CAB, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJN, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AMC, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BO, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein PC, Bandeira N. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nat Biotechnol. 2016 08 09; 34(8):828-837. PMID: 27504778.
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    16. Jensen PR. Natural Products and the Gene Cluster Revolution. Trends Microbiol. 2016 12; 24(12):968-977. PMID: 27491886.
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    17. Gallagher KA, Jensen PR. Genomic insights into the evolution of hybrid isoprenoid biosynthetic gene clusters in the MAR4 marine streptomycete clade. BMC Genomics. 2015 Nov 17; 16:960. PMID: 26578069; PMCID: PMC4650096.
    18. Tang X, Li J, Millán-Aguiñaga N, Zhang JJ, O'Neill EC, Ugalde JA, Jensen PR, Mantovani SM, Moore BS. Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining. ACS Chem Biol. 2015 Dec 18; 10(12):2841-2849. PMID: 26458099; PMCID: PMC4758359 [Available on 12/18/16].
    19. Rückert C, Leipoldt F, Zeyhle P, Fenical W, Jensen PR, Kalinowski J, Heide L, Kaysser L. Complete genome sequence of Streptomyces sp. CNQ-509, a prolific producer of meroterpenoid chemistry. J Biotechnol. 2015 Dec 20; 216:140-1. PMID: 26319318.
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    20. Choi EJ, Nam SJ, Paul L, Beatty D, Kauffman CA, Jensen PR, Fenical W. Previously Uncultured Marine Bacteria Linked to Novel Alkaloid Production. Chem Biol. 2015 Sep 17; 22(9):1270-9. PMID: 26299672.
      View in: PubMed
    21. Patin NV, Duncan KR, Dorrestein PC, Jensen PR. Competitive strategies differentiate closely related species of marine actinobacteria. ISME J. 2016 Feb; 10(2):478-90. PMID: 26241505; PMCID: PMC4737938 [Available on 02/01/17].
    22. Nam SJ, Kauffman CA, Jensen PR, Moore CE, Rheingold AL, Fenical W. Actinobenzoquinoline and Actinophenanthrolines A-C, Unprecedented Alkaloids from a Marine Actinobacterium. Org Lett. 2015 Jul 02; 17(13):3240-3. PMID: 26084575.
      View in: PubMed
    23. Jensen PR, Moore BS, Fenical W. The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery. Nat Prod Rep. 2015 May; 32(5):738-51. PMID: 25730728; PMCID: PMC4414829.
    24. Duncan KR, Crüsemann M, Lechner A, Sarkar A, Li J, Ziemert N, Wang M, Bandeira N, Moore BS, Dorrestein PC, Jensen PR. Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species. Chem Biol. 2015 Apr 23; 22(4):460-471. PMID: 25865308; PMCID: PMC4409930.
    25. Wietz M, Millán-Aguiñaga N, Jensen PR. CRISPR-Cas systems in the marine actinomycete Salinispora: linkages with phage defense, microdiversity and biogeography. BMC Genomics. 2014 Oct 25; 15:936. PMID: 25344663; PMCID: PMC4223832.
    26. Ziemert N, Lechner A, Wietz M, Millán-Aguiñaga N, Chavarria KL, Jensen PR. Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora. Proc Natl Acad Sci U S A. 2014 Mar 25; 111(12):E1130-9. PMID: 24616526; PMCID: PMC3970525.
    27. Farnaes L, Coufal NG, Kauffman CA, Rheingold AL, DiPasquale AG, Jensen PR, Fenical W. Napyradiomycin derivatives, produced by a marine-derived actinomycete, illustrate cytotoxicity by induction of apoptosis. J Nat Prod. 2014 Jan 24; 77(1):15-21. PMID: 24328269; PMCID: PMC3913167.
    28. Nam SJ, Kauffman CA, Paul LA, Jensen PR, Fenical W. Actinoranone, a cytotoxic meroterpenoid of unprecedented structure from a marine adapted Streptomyces sp. Org Lett. 2013 Nov 01; 15(21):5400-3. PMID: 24152065; PMCID: PMC4112586.
    29. Jensen PR, Chavarria KL, Fenical W, Moore BS, Ziemert N. Challenges and triumphs to genomics-based natural product discovery. J Ind Microbiol Biotechnol. 2014 Feb; 41(2):203-9. PMID: 24104399; PMCID: PMC3946964.
    30. Gallagher KA, Rauscher K, Pavan Ioca L, Jensen PR. Phylogenetic and chemical diversity of a hybrid-isoprenoid-producing streptomycete lineage. Appl Environ Microbiol. 2013 Nov; 79(22):6894-902. PMID: 23995934; PMCID: PMC3811536.
    31. Zafrir Ilan E, Torres MR, Prudhomme J, Le Roch K, Jensen PR, Fenical W. Farnesides A and B, sesquiterpenoid nucleoside ethers from a marine-derived Streptomyces sp., strain CNT-372 from Fiji. J Nat Prod. 2013 Sep 27; 76(9):1815-8. PMID: 23987585; PMCID: PMC3821698.
    32. Freel KC, Millán-Aguiñaga N, Jensen PR. Multilocus sequence typing reveals evidence of homologous recombination linked to antibiotic resistance in the genus Salinispora. Appl Environ Microbiol. 2013 Oct; 79(19):5997-6005. PMID: 23892741; PMCID: PMC3811353.
    33. Wietz M, Duncan K, Patin NV, Jensen PR. Antagonistic interactions mediated by marine bacteria: the role of small molecules. J Chem Ecol. 2013 Jul; 39(7):879-91. PMID: 23852047.
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    34. Cheng YB, Jensen PR, Fenical W. Cytotoxic and Antimicrobial Napyradiomycins from Two Marine-Derived, MAR 4 Streptomyces Strains. European J Org Chem. 2013 Jun 01; 2013(18). PMID: 24376369.
      View in: PubMed
    35. Prieto-Davó A, Villarreal-Gómez LJ, Forschner-Dancause S, Bull AT, Stach JE, Smith DC, Rowley DC, Jensen PR. Targeted search for actinomycetes from nearshore and deep-sea marine sediments. FEMS Microbiol Ecol. 2013 Jun; 84(3):510-8. PMID: 23360553; PMCID: PMC3654085.
    36. Lane AL, Nam SJ, Fukuda T, Yamanaka K, Kauffman CA, Jensen PR, Fenical W, Moore BS. Structures and comparative characterization of biosynthetic gene clusters for cyanosporasides, enediyne-derived natural products from marine actinomycetes. J Am Chem Soc. 2013 Mar 20; 135(11):4171-4. PMID: 23458364; PMCID: PMC3611589.
    37. Alvarez-Mico X, Jensen PR, Fenical W, Hughes CC. Chlorizidine, a cytotoxic 5H-pyrrolo[2,1-a]isoindol-5-one-containing alkaloid from a marine Streptomyces sp. Org Lett. 2013 Mar 01; 15(5):988-91. PMID: 23405849; PMCID: PMC3702164.
    38. Ahmed L, Jensen PR, Freel KC, Brown R, Jones AL, Kim BY, Goodfellow M. Salinispora pacifica sp. nov., an actinomycete from marine sediments. Antonie Van Leeuwenhoek. 2013 May; 103(5):1069-78. PMID: 23361994.
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    39. Becerril-Espinosa A, Freel KC, Jensen PR, Soria-Mercado IE. Marine Actinobacteria from the Gulf of California: diversity, abundance and secondary metabolite biosynthetic potential. Antonie Van Leeuwenhoek. 2013 Apr; 103(4):809-19. PMID: 23229438; PMCID: PMC4517938.
    40. Haste NM, Thienphrapa W, Tran DN, Loesgen S, Sun P, Nam SJ, Jensen PR, Fenical W, Sakoulas G, Nizet V, Hensler ME. Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureus. J Antibiot (Tokyo). 2012 Dec; 65(12):593-8. PMID: 23047246; PMCID: PMC3528839.
    41. Kaysser L, Bernhardt P, Nam SJ, Loesgen S, Ruby JG, Skewes-Cox P, Jensen PR, Fenical W, Moore BS. Merochlorins A-D, cyclic meroterpenoid antibiotics biosynthesized in divergent pathways with vanadium-dependent chloroperoxidases. J Am Chem Soc. 2012 Jul 25; 134(29):11988-91. PMID: 22784372; PMCID: PMC3410959.
    42. Choi EJ, Beatty DS, Paul LA, Fenical W, Jensen PR. Mooreia alkaloidigena gen. nov., sp. nov. and Catalinimonas alkaloidigena gen. nov., sp. nov., alkaloid-producing marine bacteria in the proposed families Mooreiaceae fam. nov. and Catalimonadaceae fam. nov. in the phylum Bacteroidetes. Int J Syst Evol Microbiol. 2013 Apr; 63(Pt 4):1219-28. PMID: 22753528; PMCID: PMC3709535.
    43. Gonzalez DJ, Xu Y, Yang YL, Esquenazi E, Liu WT, Edlund A, Duong T, Du L, Molnár I, Gerwick WH, Jensen PR, Fischbach M, Liaw CC, Straight P, Nizet V, Dorrestein PC. Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes. J Proteomics. 2012 Aug 30; 75(16):5069-76. PMID: 22641157; PMCID: PMC3543690.
    44. Bucarey SA, Penn K, Paul L, Fenical W, Jensen PR. Genetic complementation of the obligate marine actinobacterium Salinispora tropica with the large mechanosensitive channel gene mscL rescues cells from osmotic downshock. Appl Environ Microbiol. 2012 Jun; 78(12):4175-82. PMID: 22492446; PMCID: PMC3370544.
    45. Ziemert N, Podell S, Penn K, Badger JH, Allen E, Jensen PR. The natural product domain seeker NaPDoS: a phylogeny based bioinformatic tool to classify secondary metabolite gene diversity. PLoS One. 2012; 7(3):e34064. PMID: 22479523; PMCID: PMC3315503.
    46. Penn K, Jensen PR. Comparative genomics reveals evidence of marine adaptation in Salinispora species. BMC Genomics. 2012 Mar 08; 13:86. PMID: 22401625; PMCID: PMC3314556.
    47. Sakoulas G, Nam SJ, Loesgen S, Fenical W, Jensen PR, Nizet V, Hensler M. Novel bacterial metabolite merochlorin A demonstrates in vitro activity against multi-drug resistant methicillin-resistant Staphylococcus aureus. PLoS One. 2012; 7(1):e29439. PMID: 22279537; PMCID: PMC3261149.
    48. Ziemert N, Jensen PR. Phylogenetic approaches to natural product structure prediction. Methods Enzymol. 2012; 517:161-82. PMID: 23084938; PMCID: PMC4504231.
    49. Freel KC, Edlund A, Jensen PR. Microdiversity and evidence for high dispersal rates in the marine actinomycete 'Salinispora pacifica'. Environ Microbiol. 2012 Feb; 14(2):480-93. PMID: 22117917; PMCID: PMC3272088.
    50. Nam SJ, Kauffman CA, Jensen PR, Fenical W. Isolation and Characterization of Actinoramides A-C, Highly Modified Peptides from a Marine Streptomyces sp. Tetrahedron. 2011 Sep 02; 67(35):6707-6712. PMID: 21857753.
      View in: PubMed
    51. Freel KC, Nam SJ, Fenical W, Jensen PR. Evolution of secondary metabolite genes in three closely related marine actinomycete species. Appl Environ Microbiol. 2011 Oct; 77(20):7261-70. PMID: 21873479; PMCID: PMC3194868.
    52. Miyanaga A, Janso JE, McDonald L, He M, Liu H, Barbieri L, Eustáquio AS, Fielding EN, Carter GT, Jensen PR, Feng X, Leighton M, Koehn FE, Moore BS. Discovery and assembly-line biosynthesis of the lymphostin pyrroloquinoline alkaloid family of mTOR inhibitors in Salinispora bacteria. J Am Chem Soc. 2011 Aug 31; 133(34):13311-3. PMID: 21815669; PMCID: PMC3161154.
    53. Fukuda T, Miller ED, Clark BR, Alnauman A, Murphy CD, Jensen PR, Fenical W. Structures and biosynthesis of the pyridinopyrones, polyenepyrones from a marine-derived Streptomyces species. J Nat Prod. 2011 Aug 26; 74(8):1773-8. PMID: 21751787; PMCID: PMC3163021.
    54. Edlund A, Loesgen S, Fenical W, Jensen PR. Geographic distribution of secondary metabolite genes in the marine actinomycete Salinispora arenicola. Appl Environ Microbiol. 2011 Sep; 77(17):5916-25. PMID: 21724881; PMCID: PMC3165397.
    55. Sun P, Maloney KN, Nam SJ, Haste NM, Raju R, Aalbersberg W, Jensen PR, Nizet V, Hensler ME, Fenical W. Fijimycins A-C, three antibacterial etamycin-class depsipeptides from a marine-derived Streptomyces sp. Bioorg Med Chem. 2011 Nov 15; 19(22):6557-62. PMID: 21745747; PMCID: PMC3205191.
    56. Field LD, Li HL, Dalgarno SJ, Jensen P, McIntosh RD. Synthesis and characterization of iron(II) and ruthenium(II) hydrido hydrazine complexes. Inorg Chem. 2011 Jun 20; 50(12):5468-76. PMID: 21618998.
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    57. Haste NM, Hughes CC, Tran DN, Fenical W, Jensen PR, Nizet V, Hensler ME. Pharmacological properties of the marine natural product marinopyrrole A against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2011 Jul; 55(7):3305-12. PMID: 21502631; PMCID: PMC3122406.
    58. Wilson MC, Nam SJ, Gulder TA, Kauffman CA, Jensen PR, Fenical W, Moore BS. Structure and biosynthesis of the marine streptomycete ansamycin ansalactam A and its distinctive branched chain polyketide extender unit. J Am Chem Soc. 2011 Feb 16; 133(6):1971-7. PMID: 21247149; PMCID: PMC3091981.
    59. Eustáquio AS, Nam SJ, Penn K, Lechner A, Wilson MC, Fenical W, Jensen PR, Moore BS. The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolution. Chembiochem. 2011 Jan 03; 12(1):61-4. PMID: 21154492; PMCID: PMC3088357.
    60. Kwon HC, Espindola AP, Park JS, Prieto-Davó A, Rose M, Jensen PR, Fenical W. Nitropyrrolins A-E, cytotoxic farnesyl-a-nitropyrroles from a marine-derived bacterium within the actinomycete family Streptomycetaceae. J Nat Prod. 2010 Dec 27; 73(12):2047-52. PMID: 21090803; PMCID: PMC3077121.
    61. Gallagher KA, Fenical W, Jensen PR. Hybrid isoprenoid secondary metabolite production in terrestrial and marine actinomycetes. Curr Opin Biotechnol. 2010 Dec; 21(6):794-800. PMID: 20951024.
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    62. Nam SJ, Gaudêncio SP, Kauffman CA, Jensen PR, Kondratyuk TP, Marler LE, Pezzuto JM, Fenical W. Fijiolides A and B, inhibitors of TNF-alpha-induced NFkappaB activation, from a marine-derived sediment bacterium of the genus Nocardiopsis. J Nat Prod. 2010 Jun 25; 73(6):1080-6. PMID: 20481500; PMCID: PMC2901511.
    63. Murphy BT, Narender T, Kauffman CA, Woolery M, Jensen PR, Fenical W. Saliniquinones A-F, New Members of the Highly Cytotoxic Anthraquinone-?-Pyrones from the Marine Actinomycete Salinispora arenicola. Aust J Chem. 2010 Jun 01; 63(6). PMID: 24223427.
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    64. Oh H, Jensen PR, Murphy BT, Fiorilla C, Sullivan JF, Ramsey T, Fenical W. Cryptosphaerolide, a cytotoxic Mcl-1 inhibitor from a marine-derived ascomycete related to the genus Cryptosphaeria. J Nat Prod. 2010 May 28; 73(5):998-1001. PMID: 20462271; PMCID: PMC2901504.
    65. Hughes CC, Kauffman CA, Jensen PR, Fenical W. Structures, reactivities, and antibiotic properties of the marinopyrroles A-F. J Org Chem. 2010 May 21; 75(10):3240-50. PMID: 20405892; PMCID: PMC2884375.
    66. Haste NM, Perera VR, Maloney KN, Tran DN, Jensen P, Fenical W, Nizet V, Hensler ME. Activity of the streptogramin antibiotic etamycin against methicillin-resistant Staphylococcus aureus. J Antibiot (Tokyo). 2010 May; 63(5):219-24. PMID: 20339399; PMCID: PMC2889693.
    67. Meyer SW, Mordhorst TF, Lee C, Jensen PR, Fenical W, Köck M. Penilumamide, a novel lumazine peptide isolated from the marine-derived fungus, Penicillium sp. CNL-338. Org Biomol Chem. 2010 May 07; 8(9):2158-63. PMID: 20401392; PMCID: PMC3779348.
    68. Gontang EA, Gaudêncio SP, Fenical W, Jensen PR. Sequence-based analysis of secondary-metabolite biosynthesis in marine actinobacteria. Appl Environ Microbiol. 2010 Apr; 76(8):2487-99. PMID: 20154113; PMCID: PMC2849207.
    69. Clegg JK, Iremonger SS, Hayter MJ, Southon PD, Macquart RB, Duriska MB, Jensen P, Turner P, Jolliffe KA, Kepert CJ, Meehan GV, Lindoy LF. Hierarchical self-assembly of a chiral metal-organic framework displaying pronounced porosity. Angew Chem Int Ed Engl. 2010 Feb 01; 49(6):1075-8. PMID: 20058285.
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    70. Jensen PR. Linking species concepts to natural product discovery in the post-genomic era. J Ind Microbiol Biotechnol. 2010 Mar; 37(3):219-24. PMID: 20033830; PMCID: PMC2820216.
    71. Maloney KN, Macmillan JB, Kauffman CA, Jensen PR, Dipasquale AG, Rheingold AL, Fenical W. Lodopyridone, a structurally unprecedented alkaloid from a marine actinomycete. Org Lett. 2009 Dec 03; 11(23):5422-4. PMID: 19883103; PMCID: PMC2820114.
    72. Asolkar RN, Kirkland TN, Jensen PR, Fenical W. Arenimycin, an antibiotic effective against rifampin- and methicillin-resistant Staphylococcus aureus from the marine actinomycete Salinispora arenicola. J Antibiot (Tokyo). 2010 Jan; 63(1):37-9. PMID: 19927167; PMCID: PMC2825372.
    73. Penn K, Jenkins C, Nett M, Udwary DW, Gontang EA, McGlinchey RP, Foster B, Lapidus A, Podell S, Allen EE, Moore BS, Jensen PR. Genomic islands link secondary metabolism to functional adaptation in marine Actinobacteria. ISME J. 2009 Oct; 3(10):1193-203. PMID: 19474814; PMCID: PMC2749086.
    74. Strangman WK, Kwon HC, Broide D, Jensen PR, Fenical W. Potent inhibitors of pro-inflammatory cytokine production produced by a marine-derived bacterium. J Med Chem. 2009 Apr 23; 52(8):2317-27. PMID: 19323483; PMCID: PMC2735501.
    75. Asolkar RN, Freel KC, Jensen PR, Fenical W, Kondratyuk TP, Park EJ, Pezzuto JM. Arenamides A-C, cytotoxic NFkappaB inhibitors from the marine actinomycete Salinispora arenicola. J Nat Prod. 2009 Mar 27; 72(3):396-402. PMID: 19117399; PMCID: PMC2837138.
    76. Kwon HC, Kauffman CA, Jensen PR, Fenical W. Marinisporolides, polyene-polyol macrolides from a marine actinomycete of the new genus Marinispora. J Org Chem. 2009 Jan 16; 74(2):675-84. PMID: 19132943; PMCID: PMC3186066.
    77. Hughes CC, MacMillan JB, Gaudêncio SP, Jensen PR, Fenical W. The ammosamides: structures of cell cycle modulators from a marine-derived Streptomyces species. Angew Chem Int Ed Engl. 2009; 48(4):725-7. PMID: 19090514; PMCID: PMC2819817.
    78. Boonlarppradab C, Kauffman CA, Jensen PR, Fenical W. Marineosins A and B, cytotoxic spiroaminals from a marine-derived actinomycete. Org Lett. 2008 Dec 18; 10(24):5505-8. PMID: 19007176; PMCID: PMC2654761.
    79. Fenical W, Jensen PR, Palladino MA, Lam KS, Lloyd GK, Potts BC. Discovery and development of the anticancer agent salinosporamide A (NPI-0052). Bioorg Med Chem. 2009 Mar 15; 17(6):2175-80. PMID: 19022674; PMCID: PMC2814440.
    80. Newton GL, Jensen PR, Macmillan JB, Fenical W, Fahey RC. An N-acyl homolog of mycothiol is produced in marine actinomycetes. Arch Microbiol. 2008 Nov; 190(5):547-57. PMID: 18629474; PMCID: PMC2574923.
    81. Prudhomme J, McDaniel E, Ponts N, Bertani S, Fenical W, Jensen P, Le Roch K. Marine actinomycetes: a new source of compounds against the human malaria parasite. PLoS One. 2008 Jun 04; 3(6):e2335. PMID: 18523554; PMCID: PMC2391291.
    82. Jensen PR, Lauro FM. An assessment of actinobacterial diversity in the marine environment. Antonie Van Leeuwenhoek. 2008 Jun; 94(1):51-62. PMID: 18500568; PMCID: PMC3375478.
    83. Schultz AW, Oh DC, Carney JR, Williamson RT, Udwary DW, Jensen PR, Gould SJ, Fenical W, Moore BS. Biosynthesis and structures of cyclomarins and cyclomarazines, prenylated cyclic peptides of marine actinobacterial origin. J Am Chem Soc. 2008 Apr 02; 130(13):4507-16. PMID: 18331040.
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    84. Oh DC, Gontang EA, Kauffman CA, Jensen PR, Fenical W. Salinipyrones and pacificanones, mixed-precursor polyketides from the marine actinomycete Salinispora pacifica. J Nat Prod. 2008 Apr; 71(4):570-5. PMID: 18321059; PMCID: PMC2820078.
    85. Hughes CC, Prieto-Davo A, Jensen PR, Fenical W. The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp. Org Lett. 2008 Feb 21; 10(4):629-31. PMID: 18205372; PMCID: PMC2820876.
    86. Martin GD, Tan LT, Jensen PR, Dimayuga RE, Fairchild CR, Raventos-Suarez C, Fenical W. Marmycins A and B, cytotoxic pentacyclic C-glycosides from a marine sediment-derived actinomycete related to the genus Streptomyces. J Nat Prod. 2007 Sep; 70(9):1406-9. PMID: 17844998.
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    87. Cho JY, Williams PG, Kwon HC, Jensen PR, Fenical W. Lucentamycins A-D, cytotoxic peptides from the marine-derived actinomycete Nocardiopsis lucentensis. J Nat Prod. 2007 Aug; 70(8):1321-8. PMID: 17630797.
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    88. Udwary DW, Zeigler L, Asolkar RN, Singan V, Lapidus A, Fenical W, Jensen PR, Moore BS. Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica. Proc Natl Acad Sci U S A. 2007 Jun 19; 104(25):10376-81. PMID: 17563368; PMCID: PMC1965521.
    89. Gontang EA, Fenical W, Jensen PR. Phylogenetic diversity of gram-positive bacteria cultured from marine sediments. Appl Environ Microbiol. 2007 May; 73(10):3272-82. PMID: 17400789; PMCID: PMC1907118.
    90. Oh DC, Strangman WK, Kauffman CA, Jensen PR, Fenical W. Thalassospiramides A and B, immunosuppressive peptides from the marine bacterium Thalassospira sp. Org Lett. 2007 Apr 12; 9(8):1525-8. PMID: 17373804.
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    91. Oh DC, Kauffman CA, Jensen PR, Fenical W. Induced production of emericellamides A and B from the marine-derived fungus Emericella sp. in competing co-culture. J Nat Prod. 2007 Apr; 70(4):515-20. PMID: 17323993.
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    92. Williams PG, Miller ED, Asolkar RN, Jensen PR, Fenical W. Arenicolides A-C, 26-membered ring macrolides from the marine actinomycete Salinispora arenicola. J Org Chem. 2007 Jul 06; 72(14):5025-34. PMID: 17266372; PMCID: PMC2577615.
    93. Miller ED, Kauffman CA, Jensen PR, Fenical W. Piperazimycins: cytotoxic hexadepsipeptides from a marine-derived bacterium of the genus Streptomyces. J Org Chem. 2007 Jan 19; 72(2):323-30. PMID: 17221946.
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    94. Williams PG, Asolkar RN, Kondratyuk T, Pezzuto JM, Jensen PR, Fenical W. Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicola. J Nat Prod. 2007 Jan; 70(1):83-8. PMID: 17253854.
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    95. Jensen PR, Williams PG, Oh DC, Zeigler L, Fenical W. Species-specific secondary metabolite production in marine actinomycetes of the genus Salinispora. Appl Environ Microbiol. 2007 Feb; 73(4):1146-52. PMID: 17158611; PMCID: PMC1828645.
    96. Fenical W, Jensen PR. Developing a new resource for drug discovery: marine actinomycete bacteria. Nat Chem Biol. 2006 Dec; 2(12):666-73. PMID: 17108984.
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    97. Asolkar RN, Jensen PR, Kauffman CA, Fenical W. Daryamides A-C, weakly cytotoxic polyketides from a marine-derived actinomycete of the genus Streptomyces strain CNQ-085. J Nat Prod. 2006 Dec; 69(12):1756-9. PMID: 17190455.
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    98. Bugni TS, Woolery M, Kauffman CA, Jensen PR, Fenical W. Bohemamines from a marine-derived Streptomyces sp. J Nat Prod. 2006 Nov; 69(11):1626-8. PMID: 17125235.
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    99. Jensen PR, Mafnas C. Biogeography of the marine actinomycete Salinispora. Environ Microbiol. 2006 Nov; 8(11):1881-8. PMID: 17014488.
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    100. Cho JY, Kwon HC, Williams PG, Jensen PR, Fenical W. Azamerone, a terpenoid phthalazinone from a marine-derived bacterium related to the genus Streptomyces (Actinomycetales). Org Lett. 2006 Jun 08; 8(12):2471-4. PMID: 16737291; PMCID: PMC2596804.
    101. Oh DC, Williams PG, Kauffman CA, Jensen PR, Fenical W. Cyanosporasides A and B, chloro- and cyano-cyclopenta[a]indene glycosides from the marine actinomycete "Salinispora pacifica". Org Lett. 2006 Mar 16; 8(6):1021-4. PMID: 16524258.
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    102. Cho JY, Kwon HC, Williams PG, Kauffman CA, Jensen PR, Fenical W. Actinofuranones A and B, polyketides from a marine-derived bacterium related to the genus streptomyces (actinomycetales). J Nat Prod. 2006 Mar; 69(3):425-8. PMID: 16562851.
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    103. Cueto M, MacMillan JB, Jensen PR, Fenical W. Tropolactones A-D, four meroterpenoids from a marine-derived fungus of the genus Aspergillus. Phytochemistry. 2006 Aug; 67(16):1826-31. PMID: 16500687.
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    104. Kwon HC, Kauffman CA, Jensen PR, Fenical W. Marinomycins A-D, antitumor-antibiotics of a new structure class from a marine actinomycete of the recently discovered genus "marinispora". J Am Chem Soc. 2006 Feb 08; 128(5):1622-32. PMID: 16448135.
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    105. Mincer TJ, Fenical W, Jensen PR. Culture-dependent and culture-independent diversity within the obligate marine actinomycete genus Salinispora. Appl Environ Microbiol. 2005 Nov; 71(11):7019-28. PMID: 16269737; PMCID: PMC1287694.
    106. Oh DC, Jensen PR, Kauffman CA, Fenical W. Libertellenones A-D: induction of cytotoxic diterpenoid biosynthesis by marine microbial competition. Bioorg Med Chem. 2005 Sep 01; 13(17):5267-73. PMID: 15993608.
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    107. Maldonado LA, Fenical W, Jensen PR, Kauffman CA, Mincer TJ, Ward AC, Bull AT, Goodfellow M. Salinispora arenicola gen. nov., sp. nov. and Salinispora tropica sp. nov., obligate marine actinomycetes belonging to the family Micromonosporaceae. Int J Syst Evol Microbiol. 2005 Sep; 55(Pt 5):1759-66. PMID: 16166663.
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    108. Williams PG, Buchanan GO, Feling RH, Kauffman CA, Jensen PR, Fenical W. New cytotoxic salinosporamides from the marine Actinomycete Salinispora tropica. J Org Chem. 2005 Aug 05; 70(16):6196-203. PMID: 16050677.
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    109. Jensen PR, Gontang E, Mafnas C, Mincer TJ, Fenical W. Culturable marine actinomycete diversity from tropical Pacific Ocean sediments. Environ Microbiol. 2005 Jul; 7(7):1039-48. PMID: 15946301.
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    110. Buchanan GO, Williams PG, Feling RH, Kauffman CA, Jensen PR, Fenical W. Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica. Org Lett. 2005 Jun 23; 7(13):2731-4. PMID: 15957933.
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    111. Macherla VR, Mitchell SS, Manam RR, Reed KA, Chao TH, Nicholson B, Deyanat-Yazdi G, Mai B, Jensen PR, Fenical WF, Neuteboom ST, Lam KS, Palladino MA, Potts BC. Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor. J Med Chem. 2005 Jun 02; 48(11):3684-7. PMID: 15916417.
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    112. Soria-Mercado IE, Prieto-Davo A, Jensen PR, Fenical W. Antibiotic terpenoid chloro-dihydroquinones from a new marine actinomycete. J Nat Prod. 2005 Jun; 68(6):904-10. PMID: 15974616.
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    113. Jensen PR, Mincer TJ, Williams PG, Fenical W. Marine actinomycete diversity and natural product discovery. Antonie Van Leeuwenhoek. 2005 Jan; 87(1):43-8. PMID: 15726290.
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    114. Mincer TJ, Spyere A, Jensen PR, Fenical W. Phylogenetic analyses and diterpenoid production by marine bacteria of the genus Saprospira. Curr Microbiol. 2004 Oct; 49(4):300-7. PMID: 15386120.
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    115. Rowley DC, Kelly S, Jensen P, Fenical W. Synthesis and structure-activity relationships of the halovirs, antiviral natural products from a marine-derived fungus. Bioorg Med Chem. 2004 Sep 15; 12(18):4929-36. PMID: 15336272.
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    116. Tan RX, Jensen PR, Williams PG, Fenical W. Isolation and structure assignments of rostratins A-D, cytotoxic disulfides produced by the marine-derived fungus Exserohilum rostratum. J Nat Prod. 2004 Aug; 67(8):1374-82. PMID: 15332857.
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    117. Tan LT, Cheng XC, Jensen PR, Fenical W. Scytalidamides A and B, new cytotoxic cyclic heptapeptides from a marine fungus of the genus Scytalidium. J Org Chem. 2003 Nov 14; 68(23):8767-73. PMID: 14604342.
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    118. Rowley DC, Kelly S, Kauffman CA, Jensen PR, Fenical W. Halovirs A-E, new antiviral agents from a marine-derived fungus of the genus Scytalidium. Bioorg Med Chem. 2003 Sep 15; 11(19):4263-74. PMID: 12951157.
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    119. Liu Z, Jensen PR, Fenical W. A cyclic carbonate and related polyketides from a marine-derived fungus of the genus Phoma. Phytochemistry. 2003 Sep; 64(2):571-4. PMID: 12943777.
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    120. Spyere A, Rowley DC, Jensen PR, Fenical W. New neoverrucosane diterpenoids produced by the marine gliding bacterium Saprospira grandis. J Nat Prod. 2003 Jun; 66(6):818-22. PMID: 12828468.
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    121. Kubanek J, Jensen PR, Keifer PA, Sullards MC, Collins DO, Fenical W. Seaweed resistance to microbial attack: a targeted chemical defense against marine fungi. Proc Natl Acad Sci U S A. 2003 Jun 10; 100(12):6916-21. PMID: 12756301; PMCID: PMC165804.
    122. Garo E, Starks CM, Jensen PR, Fenical W, Lobkovsky E, Clardy J. Trichodermamides A and B, cytotoxic modified dipeptides from the marine-derived fungus Trichoderma virens. J Nat Prod. 2003 Mar; 66(3):423-6. PMID: 12662106.
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    123. Feling RH, Buchanan GO, Mincer TJ, Kauffman CA, Jensen PR, Fenical W. Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora. Angew Chem Int Ed Engl. 2003 Jan 20; 42(3):355-7. PMID: 12548698.
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    124. Engel S, Jensen PR, Fenical W. Chemical ecology of marine microbial defense. J Chem Ecol. 2002 Oct; 28(10):1971-85. PMID: 12474894.
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    125. Mincer TJ, Jensen PR, Kauffman CA, Fenical W. Widespread and persistent populations of a major new marine actinomycete taxon in ocean sediments. Appl Environ Microbiol. 2002 Oct; 68(10):5005-11. PMID: 12324350; PMCID: PMC126404.
    126. Cueto M, Jensen PR, Fenical W. Aspergilloxide, a novel sesterterpene epoxide from a marine-derived fungus of the genus Aspergillus. Org Lett. 2002 May 02; 4(9):1583-5. PMID: 11975634.
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