April Lukowski

Title(s)	Assistant Professor, Scripps Institution of Oceanography Department
School	Vc-marine Sciences
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

Research Activities and Funding

Interrogating novel biosynthetic sources for the production of polybrominated diphenyl ethers
NIH F32ES033540Sep 1, 2021 - Aug 31, 2024
Role: Principal Investigator

Biocatalytic approaches to antiepileptic drug targets
NIH F31NS111906May 1, 2019 - Jan 31, 2022
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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A single diiron enzyme catalyses the oxidative rearrangement of tryptophan to indole nitrile. Nat Chem. 2024 Sep 16. Adak S, Ye N, Calderone LA, Duan M, Lubeck W, Schäfer RJB, Lukowski AL, Houk KN, Pandelia ME, Drennan CL, Moore BS. PMID: 39285206.

View in: PubMed Mentions: Fields:
Che Chemistry
Translation:Cells
Enzymatic Halogenation of Terminal Alkynes. J Am Chem Soc. 2023 08 30; 145(34):18716-18721. Lukowski AL, Hubert FM, Ngo TE, Avalon NE, Gerwick WH, Moore BS. PMID: 37594919; PMCID: PMC10486310.

View in: PubMed Mentions: 5 Fields:
Che Chemistry
Translation:Cells
Oxidative rearrangement of tryptophan to indole nitrile by a single diiron enzyme. bioRxiv. 2023 Aug 03. Adak S, Ye N, Calderone LA, Schäfer RJB, Lukowski AL, Pandelia ME, Drennan CL, Moore BS. PMID: 37577561; PMCID: PMC10418191.

View in: PubMed Mentions:
Biocatalytic oxidative cross-coupling reactions for biaryl bond formation. Nature. 2022 03; 603(7899):79-85. Zetzsche LE, Yazarians JA, Chakrabarty S, Hinze ME, Murray LAM, Lukowski AL, Joyce LA, Narayan ARH. PMID: 35236972; PMCID: PMC9213091.

View in: PubMed Mentions: 32 Fields:
Sci Science
Translation:Cells
From Tryptophan to Toxin: Nature's Convergent Biosynthetic Strategy to Aetokthonotoxin. J Am Chem Soc. 2022 02 23; 144(7):2861-2866. Adak S, Lukowski AL, Schäfer RJB, Moore BS. PMID: 35142504; PMCID: PMC9004672.

View in: PubMed Mentions: 17 Fields:
Che Chemistry
Translation:Cells
Harnessing ortho-Quinone Methides in Natural Product Biosynthesis and Biocatalysis. J Nat Prod. 2022 03 25; 85(3):688-701. Purdy TN, Moore BS, Lukowski AL. PMID: 35108487; PMCID: PMC9006567.

View in: PubMed Mentions: 3 Fields:
Pha Pharmacology
Translation:Cells
Design principles for site-selective hydroxylation by a Rieske oxygenase. Nat Commun. 2022 01 11; 13(1):255. Liu J, Tian J, Perry C, Lukowski AL, Doukov TI, Narayan ARH, Bridwell-Rabb J. PMID: 35017498; PMCID: PMC8752792.

View in: PubMed Mentions: 11 Fields:
Bio Biology Sci Science
Translation:Cells
Structural basis for divergent C-H hydroxylation selectivity in two Rieske oxygenases. Nat Commun. 2020 06 12; 11(1):2991. Lukowski AL, Liu J, Bridwell-Rabb J, Narayan ARH. PMID: 32532989; PMCID: PMC7293229.

View in: PubMed Mentions: 20 Fields:
Bio Biology Sci Science
Translation:Cells
The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6. Neurosci Lett. 2020 04 17; 724:134853. Denomme N, Lukowski AL, Hull JM, Jameson MB, Bouza AA, Narayan ARH, Isom LL. PMID: 32114117; PMCID: PMC7096269.

View in: PubMed Mentions: 8 Fields:
Neu Neurology
Translation:Humans Animals Cells
Substrate Promiscuity of a Paralytic Shellfish Toxin Amidinotransferase. ACS Chem Biol. 2020 03 20; 15(3):626-631. Lukowski AL, Mallik L, Hinze ME, Carlson BM, Ellinwood DC, Pyser JB, Koutmos M, Narayan ARH. PMID: 32058687; PMCID: PMC7362304.

View in: PubMed Mentions: 8 Fields:
Bio Biochemistry Bio Biology
Translation:Cells
Biocatalytic Detoxification of Paralytic Shellfish Toxins. ACS Chem Biol. 2019 05 17; 14(5):941-948. Lukowski AL, Denomme N, Hinze ME, Hall S, Isom LL, Narayan ARH. PMID: 30983320; PMCID: PMC6528162.

View in: PubMed Mentions: 16 Fields:
Bio Biochemistry Bio Biology
Translation:Animals Cells
Natural Voltage-Gated Sodium Channel Ligands: Biosynthesis and Biology. Chembiochem. 2019 05 15; 20(10):1231-1241. Lukowski AL, Narayan ARH. PMID: 30605564; PMCID: PMC6579537.

View in: PubMed Mentions: 4 Fields:
Bio Biochemistry
Translation:Animals Cells
Structural basis for selectivity in flavin-dependent monooxygenase-catalyzed oxidative dearomatization. ACS Catal. 2019 Apr 05; 9(4):3633-3640. Benítez AR, Tweedy S, Baker Dockrey SA, Lukowski AL, Wymore T, Khare D, Brooks CL, Palfey BA, Smith JL, Narayan ARH. PMID: 31346489; PMCID: PMC6658140.

View in: PubMed Mentions: 18
C-H Hydroxylation in Paralytic Shellfish Toxin Biosynthesis. J Am Chem Soc. 2018 09 19; 140(37):11863-11869. Lukowski AL, Ellinwood DC, Hinze ME, DeLuca RJ, Du Bois J, Hall S, Narayan ARH. PMID: 30192526; PMCID: PMC6558983.

View in: PubMed Mentions: 28 Fields:
Che Chemistry
Translation:Animals Cells
Biocatalytic site- and enantioselective oxidative dearomatization of phenols. Nat Chem. 2018 02; 10(2):119-125. Baker Dockrey SA, Lukowski AL, Becker MR, Narayan ARH. PMID: 29359749; PMCID: PMC6503525.

View in: PubMed Mentions: 48 Fields:
Che Chemistry
Translation:Cells