Lena Gerwick

Title(s)Recall Non-faculty Academic, Center for Marine Biotechnology and Biomedecine
SchoolVc-marine Sciences
Address9500 Gilman Drive #
La Jolla CA 92093
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    Development of an efficient cyanobacterial platform for heterologous expression and biosynthetic interrogations of natural products.
    NIH R01GM118815Jan 12, 2017 - Dec 31, 2020
    Role: Principal Investigator
    Unified Computation Tools for Natural Products Research
    NIH R01GM107550Sep 5, 2013 - Apr 30, 2025
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Structure of a putative terminal amidation domain in natural product biosynthesis. Structure. 2025 May 01; 33(5):935-947.e4. Rankin MR, Khare D, Gerwick L, Sherman DH, Gerwick WH, Smith JL. PMID: 40086440; PMCID: PMC12048289.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    2. Fatuamide A, a Hybrid PKS/NRPS Metallophore from a Leptolyngbya sp. Marine Cyanobacterium Collected in American Samoa. J Nat Prod. 2025 Feb 28; 88(2):322-335. Alexander KL, Naman CB, Iwasaki A, Mangoni A, Leao T, Reher R, Petras D, Kim H, Ternon E, Caro-Diaz EJE, Glukhov E, Mitrevska JA, Avalon NE, Duggan BM, Gerwick L, Gerwick WH. PMID: 39879528; PMCID: PMC11877528.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Correction to "Structure and Biosynthesis of Hectoramide B, a Linear Depsipeptide from Marine Cyanobacterium Moorena producens JHB Discovered via Coculture with Candida albicans". ACS Chem Biol. 2024 Dec 20; 19(12):2593. Ngo TE, Ecker A, Ryu B, Guild A, Remmel A, Boudreau PD, Alexander KL, Naman CB, Glukhov E, Avalon NE, Shende VV, Thomas L, Dahesh S, Nizet V, Gerwick L, Gerwick WH. PMID: 39591979; PMCID: PMC11667661.
      View in: PubMed   Mentions:    Fields:    
    4. Structure of a Putative Terminal Amidation Domain in Natural Product Biosynthesis. bioRxiv. 2024 Oct 28. Rankin MR, Khare D, Gerwick L, Sherman DH, Gerwick WH, Smith JL. PMID: 39554124; PMCID: PMC11565732.
      View in: PubMed   Mentions:
    5. Leptochelins A-C, Cytotoxic Metallophores Produced by Geographically Dispersed Leptothoe Strains of Marine Cyanobacteria. J Am Chem Soc. 2024 Jul 10; 146(27):18626-18638. Avalon NE, Reis MA, Thornburg CC, Williamson RT, Petras D, Aron AT, Neuhaus GF, Al-Hindy M, Mitrevska J, Ferreira L, Morais J, El Abiead Y, Glukhov E, Alexander KL, Vulpanovici FA, Bertin MJ, Whitner S, Choi H, Spengler G, Blinov K, Almohammadi AM, Shaala LA, Kew WR, Paša-Tolic L, Youssef DTA, Dorrestein PC, Vasconcelos V, Gerwick L, McPhail KL, Gerwick WH. PMID: 38918178; PMCID: PMC11240249.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    6. Structure and Biosynthesis of Hectoramide B, a Linear Depsipeptide from Marine Cyanobacterium Moorena producens JHB Discovered via Coculture with Candida albicans. ACS Chem Biol. 2024 03 15; 19(3):619-628. Ngo TE, Ecker A, Ryu B, Guild A, Remmel A, Boudreau PD, Alexander KL, Naman CB, Glukhov E, Avalon NE, Shende VV, Thomas L, Dahesh S, Nizet V, Gerwick L, Gerwick WH. PMID: 38330248; PMCID: PMC10949194.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    7. Structure and Biosynthesis of Hectoramide B, a Linear Depsipeptide from the Marine Cyanobacterium Moorena producens JHB Discovered via Co-culture with Candida albicans. bioRxiv. 2023 Jul 06. Ngo TE, Ecker A, Guild A, Remmel A, Boudreau PD, Alexander KL, Naman CB, Glukhov E, Avalon NE, Shende VV, Gerwick L, Gerwick WH. PMID: 37461655; PMCID: PMC10350029.
      View in: PubMed   Mentions:
    8. NPOmix: A machine learning classifier to connect mass spectrometry fragmentation data to biosynthetic gene clusters. PNAS Nexus. 2022 Nov; 1(5):pgac257. Leão TF, Wang M, da Silva R, Gurevich A, Bauermeister A, Gomes PWP, Brejnrod A, Glukhov E, Aron AT, Louwen JJR, Kim HW, Reher R, Fiore MF, van der Hooft JJJ, Gerwick L, Gerwick WH, Bandeira N, Dorrestein PC. PMID: 36712343; PMCID: PMC9802219.
      View in: PubMed   Mentions: 7  
    9. Heterologous Expression in Anabaena of the Columbamide Pathway from the Cyanobacterium Moorena bouillonii and Production of New Analogs. ACS Chem Biol. 2022 07 15; 17(7):1910-1923. Taton A, Rohrer S, Diaz B, Reher R, Caraballo Rodriguez AM, Pierce ML, Dorrestein PC, Gerwick L, Gerwick WH, Golden JW. PMID: 35761435.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    10. Portobelamides A and B and Caciqueamide, Cytotoxic Peptidic Natural Products from a Caldora sp. Marine Cyanobacterium. J Nat Prod. 2021 08 27; 84(8):2081-2093. Demirkiran O, Almaliti J, Leão T, Navarro G, Byrum T, Valeriote FA, Gerwick L, Gerwick WH. PMID: 34269583.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    11. A community resource for paired genomic and metabolomic data mining. Nat Chem Biol. 2021 04; 17(4):363-368. Schorn MA, Verhoeven S, Ridder L, Huber F, Acharya DD, Aksenov AA, Aleti G, Moghaddam JA, Aron AT, Aziz S, Bauermeister A, Bauman KD, Baunach M, Beemelmanns C, Beman JM, Berlanga-Clavero MV, Blacutt AA, Bode HB, Boullie A, Brejnrod A, Bugni TS, Calteau A, Cao L, Carrión VJ, Castelo-Branco R, Chanana S, Chase AB, Chevrette MG, Costa-Lotufo LV, Crawford JM, Currie CR, Cuypers B, Dang T, de Rond T, Demko AM, Dittmann E, Du C, Drozd C, Dujardin JC, Dutton RJ, Edlund A, Fewer DP, Garg N, Gauglitz JM, Gentry EC, Gerwick L, Glukhov E, Gross H, Gugger M, Guillén Matus DG, Helfrich EJN, Hempel BF, Hur JS, Iorio M, Jensen PR, Kang KB, Kaysser L, Kelleher NL, Kim CS, Kim KH, Koester I, König GM, Leao T, Lee SR, Lee YY, Li X, Little JC, Maloney KN, Männle D, Martin H C, McAvoy AC, Metcalf WW, Mohimani H, Molina-Santiago C, Moore BS, Mullowney MW, Muskat M, Nothias LF, O'Neill EC, Parkinson EI, Petras D, Piel J, Pierce EC, Pires K, Reher R, Romero D, Roper MC, Rust M, Saad H, Saenz C, Sanchez LM, Sørensen SJ, Sosio M, Süssmuth RD, Sweeney D, Tahlan K, Thomson RJ, Tobias NJ, Trindade-Silva AE, van Wezel GP, Wang M, Weldon KC, Zhang F, Ziemert N, Duncan KR, Crüsemann M, Rogers S, Dorrestein PC, Medema MH, van der Hooft JJJ. PMID: 33589842; PMCID: PMC7987574.
      View in: PubMed   Mentions: 54     Fields:    
    12. A Multi-Omics Characterization of the Natural Product Potential of Tropical Filamentous Marine Cyanobacteria. Mar Drugs. 2021 Jan 06; 19(1). Leão T, Wang M, Moss N, da Silva R, Sanders J, Nurk S, Gurevich A, Humphrey G, Reher R, Zhu Q, Belda-Ferre P, Glukhov E, Whitner S, Alexander KL, Rex R, Pevzner P, Dorrestein PC, Knight R, Bandeira N, Gerwick WH, Gerwick L. PMID: 33418911; PMCID: PMC7825088.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    13. Natural Products with Potential to Treat RNA Virus Pathogens Including SARS-CoV-2. J Nat Prod. 2021 01 22; 84(1):161-182. Christy MP, Uekusa Y, Gerwick L, Gerwick WH. PMID: 33352046; PMCID: PMC7771248.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    14. Heterologous Expression of Cryptomaldamide in a Cyanobacterial Host. ACS Synth Biol. 2020 12 18; 9(12):3364-3376. Taton A, Ecker A, Diaz B, Moss NA, Anderson B, Reher R, Leão TF, Simkovsky R, Dorrestein PC, Gerwick L, Gerwick WH, Golden JW. PMID: 33180461; PMCID: PMC8514081.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    15. An anti-inflammatory isoflavone from soybean inoculated with a marine fungus Aspergillus terreus C23-3. Biosci Biotechnol Biochem. 2020 Aug; 84(8):1546-1553. Yang JM, Liu YY, Yang WC, Ma XX, Nie YY, Glukhov E, Gerwick L, Gerwick WH, Lei XL, Zhang Y. PMID: 32434451.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    16. Pagoamide A, a Cyclic Depsipeptide Isolated from a Cultured Marine Chlorophyte, Derbesia sp., Using MS/MS-Based Molecular Networking. J Nat Prod. 2020 03 27; 83(3):617-625. Li Y, Yu HB, Zhang Y, Leao T, Glukhov E, Pierce ML, Zhang C, Kim H, Mao HH, Fang F, Cottrell GW, Murray TF, Gerwick L, Guan H, Gerwick WH. PMID: 31916778; PMCID: PMC7210564.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    17. MetaMiner: A Scalable Peptidogenomics Approach for Discovery of Ribosomal Peptide Natural Products with Blind Modifications from Microbial Communities. Cell Syst. 2019 12 18; 9(6):600-608.e4. Cao L, Gurevich A, Alexander KL, Naman CB, Leão T, Glukhov E, Luzzatto-Knaan T, Vargas F, Quinn R, Bouslimani A, Nothias LF, Singh NK, Sanders JG, Benitez RAS, Thompson LR, Hamid MN, Morton JT, Mikheenko A, Shlemov A, Korobeynikov A, Friedberg I, Knight R, Venkateswaran K, Gerwick WH, Gerwick L, Dorrestein PC, Pevzner PA, Mohimani H. PMID: 31629686; PMCID: PMC6952069.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    18. Cytotoxic Microcolin Lipopeptides from the Marine Cyanobacterium Moorea producens. J Nat Prod. 2019 09 27; 82(9):2608-2619. Yu HB, Glukhov E, Li Y, Iwasaki A, Gerwick L, Dorrestein PC, Jiao BH, Gerwick WH. PMID: 31468974.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    19. Nature's Combinatorial Biosynthesis Produces Vatiamides A-F. Angew Chem Int Ed Engl. 2019 07 01; 58(27):9027-9031. Moss NA, Seiler G, Leão TF, Castro-Falcón G, Gerwick L, Hughes CC, Gerwick WH. PMID: 31071229; PMCID: PMC6626303.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    20. Ketoreductase Domain Dysfunction Expands Chemodiversity: Malyngamide Biosynthesis in the Cyanobacterium Okeania hirsuta. ACS Chem Biol. 2018 12 21; 13(12):3385-3395. Moss NA, Leão T, Rankin MR, McCullough TM, Qu P, Korobeynikov A, Smith JL, Gerwick L, Gerwick WH. PMID: 30444349; PMCID: PMC6470004.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    21. Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module. ACS Chem Biol. 2018 06 15; 13(6):1640-1650. Skiba MA, Sikkema AP, Moss NA, Lowell AN, Su M, Sturgis RM, Gerwick L, Gerwick WH, Sherman DH, Smith JL. PMID: 29701944; PMCID: PMC6003868.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    22. Collection, Culturing, and Genome Analyses of Tropical Marine Filamentous Benthic Cyanobacteria. Methods Enzymol. 2018; 604:3-43. Moss NA, Leao T, Glukhov E, Gerwick L, Gerwick WH. PMID: 29779657.
      View in: PubMed   Mentions: 11     Fields:    Translation:CellsPHPublic Health
    23. Samholides, Swinholide-Related Metabolites from a Marine Cyanobacterium cf. Phormidium sp. J Org Chem. 2018 03 16; 83(6):3034-3046. Tao Y, Li P, Zhang D, Glukhov E, Gerwick L, Zhang C, Murray TF, Gerwick WH. PMID: 29457979; PMCID: PMC5859247.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    24. Bastimolide B, an Antimalarial 24-Membered Marine Macrolide Possessing a tert-Butyl Group. J Nat Prod. 2018 01 26; 81(1):211-215. Shao CL, Mou XF, Cao F, Spadafora C, Glukhov E, Gerwick L, Wang CY, Gerwick WH. PMID: 29327931.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    25. Marine Natural Product Honaucin A Attenuates Inflammation by Activating the Nrf2-ARE Pathway. J Nat Prod. 2018 03 23; 81(3):506-514. Mascuch SJ, Boudreau PD, Carland TM, Pierce NT, Olson J, Hensler ME, Choi H, Campanale J, Hamdoun A, Nizet V, Gerwick WH, Gaasterland T, Gerwick L. PMID: 29215273; PMCID: PMC6553616.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    26. A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit. ACS Chem Biol. 2017 12 15; 12(12):3039-3048. Skiba MA, Sikkema AP, Moss NA, Tran CL, Sturgis RM, Gerwick L, Gerwick WH, Sherman DH, Smith JL. PMID: 29096064; PMCID: PMC5784268.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    27. Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity. J Med Chem. 2017 08 10; 60(15):6721-6732. LaMonte GM, Almaliti J, Bibo-Verdugo B, Keller L, Zou BY, Yang J, Antonova-Koch Y, Orjuela-Sanchez P, Boyle CA, Vigil E, Wang L, Goldgof GM, Gerwick L, O'Donoghue AJ, Winzeler EA, Gerwick WH, Ottilie S. PMID: 28696697; PMCID: PMC5554889.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    28. Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae. Elife. 2017 05 11; 6. Luzzatto-Knaan T, Garg N, Wang M, Glukhov E, Peng Y, Ackermann G, Amir A, Duggan BM, Ryazanov S, Gerwick L, Knight R, Alexandrov T, Bandeira N, Gerwick WH, Dorrestein PC. PMID: 28492366; PMCID: PMC5441867.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    29. A Maldiisotopic Approach to Discover Natural Products: Cryptomaldamide, a Hybrid Tripeptide from the Marine Cyanobacterium Moorea producens. J Nat Prod. 2017 05 26; 80(5):1514-1521. Kinnel RB, Esquenazi E, Leao T, Moss N, Mevers E, Pereira AR, Monroe EA, Korobeynikov A, Murray TF, Sherman D, Gerwick L, Dorrestein PC, Gerwick WH. PMID: 28448144; PMCID: PMC5748289.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    30. Comparative genomics uncovers the prolific and distinctive metabolic potential of the cyanobacterial genus Moorea. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):3198-3203. Leao T, Castelão G, Korobeynikov A, Monroe EA, Podell S, Glukhov E, Allen EE, Gerwick WH, Gerwick L. PMID: 28265051; PMCID: PMC5373345.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    31. A novel uncultured heterotrophic bacterial associate of the cyanobacterium Moorea producens JHB. BMC Microbiol. 2016 08 30; 16(1):198. Cummings ME, Barbé D, Leao TF, Korobeynikov A, Engene N, Glukhov E, Gerwick WH, Gerwick L. PMID: 27577966; PMCID: PMC5006271.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    32. Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate. Proc Natl Acad Sci U S A. 2016 09 13; 113(37):10316-21. Maloney FP, Gerwick L, Gerwick WH, Sherman DH, Smith JL. PMID: 27573844; PMCID: PMC5027445.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    33. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nat Biotechnol. 2016 08 09; 34(8):828-837. Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, P CAB, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJN, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AMC, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BO, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein PC, Bandeira N. PMID: 27504778; PMCID: PMC5321674.
      View in: PubMed   Mentions: 1593     Fields:    
    34. Unique marine derived cyanobacterial biosynthetic genes for chemical diversity. Nat Prod Rep. 2016 Feb; 33(2):348-64. Kleigrewe K, Gerwick L, Sherman DH, Gerwick WH. PMID: 26758451.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    35. The Phormidolide Biosynthetic Gene Cluster: A trans-AT PKS Pathway Encoding a Toxic Macrocyclic Polyketide. Chembiochem. 2016 Jan; 17(2):164-73. Bertin MJ, Vulpanovici A, Monroe EA, Korobeynikov A, Sherman DH, Gerwick L, Gerwick WH. PMID: 26769357; PMCID: PMC4878910.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    36. Combined LC-MS/MS and Molecular Networking Approach Reveals New Cyanotoxins from the 2014 Cyanobacterial Bloom in Green Lake, Seattle. Environ Sci Technol. 2015 Dec 15; 49(24):14301-10. Teta R, Della Sala G, Glukhov E, Gerwick L, Gerwick WH, Mangoni A, Costantino V. PMID: 26567695; PMCID: PMC4851459.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    37. Integrating mass spectrometry and genomics for cyanobacterial metabolite discovery. J Ind Microbiol Biotechnol. 2016 Mar; 43(2-3):313-24. Moss NA, Bertin MJ, Kleigrewe K, Leão TF, Gerwick L, Gerwick WH. PMID: 26578313; PMCID: PMC5065021.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    38. Minimum Information about a Biosynthetic Gene cluster. Nat Chem Biol. 2015 Sep; 11(9):625-31. Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO. PMID: 26284661; PMCID: PMC5714517.
      View in: PubMed   Mentions: 393     Fields:    
    39. Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta. J Org Chem. 2015 Aug 21; 80(16):7849-55. Shao CL, Linington RG, Balunas MJ, Centeno A, Boudreau P, Zhang C, Engene N, Spadafora C, Mutka TS, Kyle DE, Gerwick L, Wang CY, Gerwick WH. PMID: 26222145.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    40. Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows. PLoS One. 2015; 10(7):e0133297. Boudreau PD, Monroe EA, Mehrotra S, Desfor S, Korobeynikov A, Sherman DH, Murray TF, Gerwick L, Dorrestein PC, Gerwick WH. PMID: 26222584; PMCID: PMC4519256.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    41. Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria. J Nat Prod. 2015 Jul 24; 78(7):1671-82. Kleigrewe K, Almaliti J, Tian IY, Kinnel RB, Korobeynikov A, Monroe EA, Duggan BM, Di Marzo V, Sherman DH, Dorrestein PC, Gerwick L, Gerwick WH. PMID: 26149623; PMCID: PMC4681511.
      View in: PubMed   Mentions: 69     Fields:    Translation:Cells
    42. Direct detection of fungal siderophores on bats with white-nose syndrome via fluorescence microscopy-guided ambient ionization mass spectrometry. PLoS One. 2015; 10(3):e0119668. Mascuch SJ, Moree WJ, Hsu CC, Turner GG, Cheng TL, Blehert DS, Kilpatrick AM, Frick WF, Meehan MJ, Dorrestein PC, Gerwick L. PMID: 25781976; PMCID: PMC4364562.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    43. Spongosine production by a Vibrio harveyi strain associated with the sponge Tectitethya crypta. J Nat Prod. 2015 Mar 27; 78(3):493-9. Bertin MJ, Schwartz SL, Lee J, Korobeynikov A, Dorrestein PC, Gerwick L, Gerwick WH. PMID: 25668560; PMCID: PMC5065018.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    44. Comparative analysis of hapalindole, ambiguine and welwitindolinone gene clusters and reconstitution of indole-isonitrile biosynthesis from cyanobacteria. BMC Microbiol. 2014 Aug 01; 14:213. Micallef ML, Sharma D, Bunn BM, Gerwick L, Viswanathan R, Moffitt MC. PMID: 25198896; PMCID: PMC4236562.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    45. Characterization of cyanobacterial hydrocarbon composition and distribution of biosynthetic pathways. PLoS One. 2014; 9(1):e85140. Coates RC, Podell S, Korobeynikov A, Lapidus A, Pevzner P, Sherman DH, Allen EE, Gerwick L, Gerwick WH. PMID: 24475038; PMCID: PMC3903477.
      View in: PubMed   Mentions: 63     Fields:    Translation:Cells
    46. Polyketide genes in the marine sponge Plakortis simplex: a new group of mono-modular type I polyketide synthases from sponge symbionts. Environ Microbiol Rep. 2013 Dec; 5(6):809-18. Della Sala G, Hochmuth T, Costantino V, Teta R, Gerwick W, Gerwick L, Piel J, Mangoni A. PMID: 24249289; PMCID: PMC3908369.
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    47. Real-time metabolomics on living microorganisms using ambient electrospray ionization flow-probe. Anal Chem. 2013 Aug 06; 85(15):7014-8. Hsu CC, ElNaggar MS, Peng Y, Fang J, Sanchez LM, Mascuch SJ, Møller KA, Alazzeh EK, Pikula J, Quinn RA, Zeng Y, Wolfe BE, Dutton RJ, Gerwick L, Zhang L, Liu X, Månsson M, Dorrestein PC. PMID: 23819546; PMCID: PMC3890442.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    48. Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei. J Nat Prod. 2013 Apr 26; 76(4):630-41. Sanchez LM, Knudsen GM, Helbig C, De Muylder G, Mascuch SM, Mackey ZB, Gerwick L, Clayton C, McKerrow JH, Linington RG. PMID: 23445522; PMCID: PMC3971013.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    49. Structural basis of functional group activation by sulfotransferases in complex metabolic pathways. ACS Chem Biol. 2012 Dec 21; 7(12):1994-2003. McCarthy JG, Eisman EB, Kulkarni S, Gerwick L, Gerwick WH, Wipf P, Sherman DH, Smith JL. PMID: 22991895; PMCID: PMC3528841.
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    50. Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins. Org Lett. 2012 Aug 03; 14(15):3878-81. Balunas MJ, Grosso MF, Villa FA, Engene N, McPhail KL, Tidgewell K, Pineda LM, Gerwick L, Spadafora C, Kyle DE, Gerwick WH. PMID: 22794317; PMCID: PMC3449157.
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    51. Honaucins A-C, potent inhibitors of inflammation and bacterial quorum sensing: synthetic derivatives and structure-activity relationships. Chem Biol. 2012 May 25; 19(5):589-98. Choi H, Mascuch SJ, Villa FA, Byrum T, Teasdale ME, Smith JE, Preskitt LB, Rowley DC, Gerwick L, Gerwick WH. PMID: 22633410; PMCID: PMC3361693.
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    52. Molecular identification and expression analysis of two distinct BPI/LBPs (bactericidal permeability-increasing protein/LPS-binding protein) from rock bream, Oplegnathus fasciatus. Fish Shellfish Immunol. 2012 Jul; 33(1):75-84. Kim JW, Gerwick L, Park CI. PMID: 22521422.
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    53. Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A. FEBS J. 2012 Apr; 279(7):1243-51. Jones AC, Ottilie S, Eustáquio AS, Edwards DJ, Gerwick L, Moore BS, Gerwick WH. PMID: 22314229.
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    54. Structure and activity of DmmA, a marine haloalkane dehalogenase. Protein Sci. 2012 Feb; 21(2):239-48. Gehret JJ, Gu L, Geders TW, Brown WC, Gerwick L, Gerwick WH, Sherman DH, Smith JL. PMID: 22124946; PMCID: PMC3324768.
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    55. Phylogeny-guided isolation of ethyl tumonoate A from the marine cyanobacterium cf. Oscillatoria margaritifera. J Nat Prod. 2011 Aug 26; 74(8):1737-43. Engene N, Choi H, Esquenazi E, Byrum T, Villa FA, Cao Z, Murray TF, Dorrestein PC, Gerwick L, Gerwick WH. PMID: 21751786; PMCID: PMC3163041.
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    56. Differential expression and intrachromosomal evolution of the sghC1q genes in zebrafish (Danio rerio). Dev Comp Immunol. 2012 Jan; 36(1):31-8. Carland TM, Locke JB, Nizet V, Gerwick L. PMID: 21683091.
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    57. Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8815-20. Jones AC, Monroe EA, Podell S, Hess WR, Klages S, Esquenazi E, Niessen S, Hoover H, Rothmann M, Lasken RS, Yates JR, Reinhardt R, Kube M, Burkart MD, Allen EE, Dorrestein PC, Gerwick WH, Gerwick L. PMID: 21555588; PMCID: PMC3102346.
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    58. Significant natural product biosynthetic potential of actinorhizal symbionts of the genus frankia, as revealed by comparative genomic and proteomic analyses. Appl Environ Microbiol. 2011 Jun; 77(11):3617-25. Udwary DW, Gontang EA, Jones AC, Jones CS, Schultz AW, Winter JM, Yang JY, Beauchemin N, Capson TL, Clark BR, Esquenazi E, Eustáquio AS, Freel K, Gerwick L, Gerwick WH, Gonzalez D, Liu WT, Malloy KL, Maloney KN, Nett M, Nunnery JK, Penn K, Prieto-Davo A, Simmons TL, Weitz S, Wilson MC, Tisa LS, Dorrestein PC, Moore BS. PMID: 21498757; PMCID: PMC3127629.
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    59. Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage. PLoS One. 2011 Apr 12; 6(4):e18565. Grindberg RV, Ishoey T, Brinza D, Esquenazi E, Coates RC, Liu WT, Gerwick L, Dorrestein PC, Pevzner P, Lasken R, Gerwick WH. PMID: 21533272; PMCID: PMC3075265.
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    60. Malyngamide 2, an oxidized lipopeptide with nitric oxide inhibiting activity from a Papua New Guinea marine cyanobacterium. J Nat Prod. 2011 Jan 28; 74(1):95-8. Malloy KL, Villa FA, Engene N, Matainaho T, Gerwick L, Gerwick WH. PMID: 21155594; PMCID: PMC3227558.
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    61. Marine natural product drug discovery: Leads for treatment of inflammation, cancer, infections, and neurological disorders. Immunopharmacol Immunotoxicol. 2010 Jun; 32(2):228-37. Villa FA, Gerwick L. PMID: 20441539.
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    62. The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria. Nat Prod Rep. 2010 Jul; 27(7):1048-65. Jones AC, Monroe EA, Eisman EB, Gerwick L, Sherman DH, Gerwick WH. PMID: 20442916.
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    63. The C1q domain containing proteins: Where do they come from and what do they do? Dev Comp Immunol. 2010 Aug; 34(8):785-90. Carland TM, Gerwick L. PMID: 20214925.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    64. Selective MyD88-dependent pathway inhibition by the cyanobacterial natural product malyngamide F acetate. Eur J Pharmacol. 2010 Mar 10; 629(1-3):140-6. Villa FA, Lieske K, Gerwick L. PMID: 20006962; PMCID: PMC2831873.
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    65. Transcriptional analysis of the jamaicamide gene cluster from the marine cyanobacterium Lyngbya majuscula and identification of possible regulatory proteins. BMC Microbiol. 2009 Dec 01; 9:247. Jones AC, Gerwick L, Gonzalez D, Dorrestein PC, Gerwick WH. PMID: 19951434; PMCID: PMC2799420.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    66. Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis. J Am Chem Soc. 2009 Nov 11; 131(44):16033-5. Gu L, Wang B, Kulkarni A, Gehret JJ, Lloyd KR, Gerwick L, Gerwick WH, Wipf P, Håkansson K, Smith JL, Sherman DH. PMID: 19835378; PMCID: PMC2839324.
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    67. Metamorphic enzyme assembly in polyketide diversification. Nature. 2009 Jun 04; 459(7247):731-5. Gu L, Wang B, Kulkarni A, Geders TW, Grindberg RV, Gerwick L, Håkansson K, Wipf P, Smith JL, Gerwick WH, Sherman DH. PMID: 19494914; PMCID: PMC2918389.
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    68. Viridamides A and B, lipodepsipeptides with antiprotozoal activity from the marine cyanobacterium Oscillatoria nigro-viridis. J Nat Prod. 2008 Sep; 71(9):1544-50. Simmons TL, Engene N, Ureña LD, Romero LI, Ortega-Barría E, Gerwick L, Gerwick WH. PMID: 18715036; PMCID: PMC2656441.
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    69. Transcriptome profiles of livers and kidneys from three rainbow trout (Oncorhynchus mykiss) clonal lines distinguish stocks from three allopatric populations. Comp Biochem Physiol Part D Genomics Proteomics. 2006 Dec; 1(4):396-403. Bayne CJ, Gerwick L, Wheeler PA, Thorgaard GH. PMID: 20483271.
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    70. Gene transcript changes in individual rainbow trout livers following an inflammatory stimulus. Fish Shellfish Immunol. 2007 Mar; 22(3):157-71. Gerwick L, Corley-Smith G, Bayne CJ. PMID: 16762566.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    71. Use of a rainbow trout oligonucleotide microarray to determine transcriptional patterns in aflatoxin B1-induced hepatocellular carcinoma compared to adjacent liver. Toxicol Sci. 2005 Dec; 88(2):319-30. Tilton SC, Gerwick LG, Hendricks JD, Rosato CS, Corley-Smith G, Givan SA, Bailey GS, Bayne CJ, Williams DE. PMID: 16141433.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    72. Molecular cloning and characterization of rainbow trout (Oncorhynchus mykiss) CCAAT/enhancer binding protein beta. Immunogenetics. 2003 Jul; 55(4):253-61. Fujiki K, Gerwick L, Bayne CJ, Mitchell L, Gauley J, Bols N, Dixon B. PMID: 12774179.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
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