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David Brenner

TitleVice Chancellor - Health Sciences
InstitutionUniversity of California San Diego
DepartmentSchool of Medicine
Address9500 Gilman Drive #0602
La Jolla CA 92093
Phone858-534-1501
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    Other Positions
    TitleDean - School of Medicine


    Collapse Biography 
    Collapse Education and Training
    UC San DiegoFellowship1988Gastroenterology
    NIH/NIDDK, Bethesda, MDFellowship1986Genetics & Biochemistry
    Yale UniversityIntern & Residency1985Internal Medicine
    Yale UniversityMD1979Medicine
    Yale UniversityBS1975Biology

    Collapse Research 
    Collapse Research Activities and Funding
    Microbiome as Therapeutic Target in Alcoholic Hepatitis
    NIH/NIAAA U01AA021856Jun 1, 2013 - May 31, 2018
    Role: Principal Investigator
    The Role of Inflammation and Stroma in Digestive Cancer
    NIH U54CA126513Sep 30, 2006 - Sep 21, 2011
    Role: Co-Investigator
    Angiotensin II and NADPH Oxidase in Hepatic Fibrosis
    NIH/NIDDK R01DK072237Sep 15, 2005 - Jun 30, 2011
    Role: Principal Investigator
    Hepatic Stellate Cell Activation induced by Hepatitis C Virus
    NIH/NIAAA R01AA015055Sep 30, 2003 - Aug 31, 2009
    Role: Principal Investigator
    Cond. Acceptance Post-Bac. Prog. Scholarship Fund
    NIH/NIMHD S22MD000227Sep 30, 2002 - Sep 29, 2005
    Role: Principal Investigator
    Molecular Pathogenesis of Apoptosis in Liver Cells
    NIH P01DK059340Sep 21, 2001 - May 31, 2006
    Role: Co-Investigator
    ONCOGENIC K-RAS INDUCTION OF GASTRIN GENE TRANSCRIPTION
    NIH/NIDDK R01DK055686Aug 15, 2000 - Jul 31, 2006
    Role: Principal Investigator
    GENE TECHNOLOGY THERAPY AND ALCOHOL-INDUCED FIBROSIS
    NIH/NIAAA R01AA012586Sep 23, 1999 - Jun 30, 2003
    Role: Principal Investigator
    Southern California Research Center for ALPD and Cirrhosis
    NIH/NIAAA P50AA011999Jan 1, 1999 - Dec 31, 2018
    Role: Co-Investigator
    Molecular and Cellular Pathogenesis in Alcoholism
    NIH P60AA011605Dec 1, 1997 - Nov 30, 2017
    Role: Co-Investigator
    MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM
    NIH P50AA011605Dec 1, 1997 - Nov 30, 2002
    Role: Co-Investigator
    RAT MODEL OF ALCOHOLIC PANCREATITIS
    NIH/NIAAA R03AA011226Apr 1, 1997 - Mar 31, 1999
    Role: Principal Investigator
    Gastroenterology Research Training
    NIH/NIDDK T32DK007737Aug 1, 1996 - Jun 30, 2021
    Role: Principal Investigator
    GENE THERAPY FOR LIVER DISEASES
    NIH/NIDDK R13DK047627Jan 20, 1994 - Oct 31, 1994
    Role: Principal Investigator
    MOLECULAR DEFECTS IN PROTOPORPHYRIA
    NIH/NIDDK R01DK047361May 1, 1993 - May 31, 2004
    Role: Principal Investigator
    Integrated Center for InVivo Microscopy
    NIH P41RR005959Sep 1, 1990 - Jun 30, 2013
    Role: Co-Investigator
    FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS
    NIH/NCI P01CA050528Sep 8, 1989 - Jan 31, 1998
    Role: Co-Investigator
    Molecular Mechanisms by which TNFalpha Modulates Fibrosis
    NIH/NIGMS R01GM041804Apr 1, 1989 - Dec 31, 2014
    Role: Principal Investigator
    MOLECULAR DEFECT IN PROTOPORPHYRIA
    NIH/NIDDK R29DK039996Apr 1, 1988 - Mar 31, 1993
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Tripathi A, Debelius J, Brenner D, Karin M, Loomba R, Schnabl B, Knight R. The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol. 2018 May 10. PMID: 29748586.
      View in: PubMed
    2. Caussy C, Hsu C, Lo MT, Liu A, Bettencourt R, Ajmera VH, Bassirian S, Hooker J, Sy E, Richards L, Schork N, Schnabl B, Brenner D, Sirlin CB, Chen CH, Loomba R. Novel link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. Hepatology. 2018 Mar 23. PMID: 29572891.
      View in: PubMed
    3. Lan T, Li C, Yang G, Sun Y, Zhuang L, Ou Y, Li H, Wang G, Kisseleva T, Brenner D, Guo J. Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2. Hepatology. 2018 Mar 23. PMID: 29572892.
      View in: PubMed
    4. Caussy C, Chen J, Alquiraish MH, Cepin S, Nguyen P, Hernandez C, Yin M, Bettencourt R, Cachay ER, Jayakumar S, Fortney L, Hooker J, Sy E, Valasek MA, Rizo E, Richards L, Brenner D, Sirlin CB, Ehman RL, Loomba R. Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patients With Nonalcoholic Liver Disease. Clin Gastroenterol Hepatol. 2018 Jan 17. PMID: 29104128.
      View in: PubMed
    5. Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D, Kisseleva T, Brenner D, Urrutia R, Lomberk G, Gao Y, Ligresti G, Tschumperlin DJ, Revzin A, Cao S, Shah VH. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. JCI Insight. 2017 Dec 21; 2(24). PMID: 29263300.
      View in: PubMed
    6. Scelzo A, Di Somma S, Antonini P, Montross LP, Schork N, Brenner D, Jeste DV. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. Int Psychogeriatr. 2018 Jan; 30(1):31-38. PMID: 29229012.
      View in: PubMed
    7. Llorente C, Jepsen P, Inamine T, Wang L, Bluemel S, Wang HJ, Loomba R, Bajaj JS, Schubert ML, Sikaroodi M, Gillevet PM, Xu J, Kisseleva T, Ho SB, DePew J, Du X, Sørensen HT, Vilstrup H, Nelson KE, Brenner D, Fouts DE, Schnabl B. Publisher Correction: Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Nat Commun. 2017 Dec 12; 8(1):2137. PMID: 29233961.
      View in: PubMed
    8. Hartmann P, Hochrath K, Horvath A, Chen P, Seebauer CT, Llorente C, Wang L, Alnouti Y, Fouts DE, Stärkel P, Loomba R, Coulter S, Liddle C, Yu RT, Ling L, Rossi SJ, DePaoli AM, Downes M, Evans RM, Brenner D, Schnabl B. Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. Hepatology. 2017 Nov 21. PMID: 29159825.
      View in: PubMed
    9. Shang L, Hosseini M, Liu X, Kisseleva T, Brenner D. Human hepatic stellate cell isolation and characterization. J Gastroenterol. 2018 Jan; 53(1):6-17. PMID: 29094206.
      View in: PubMed
    10. Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R, Quehenberger O, Davidson NO, Dennis EA, Kisseleva T, Brenner D. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. Hepatol Commun. 2017 Dec; 1(10):1043-1057. PMID: 29404441.
      View in: PubMed
    11. Llorente C, Jepsen P, Inamine T, Wang L, Bluemel S, Wang HJ, Loomba R, Bajaj JS, Schubert ML, Sikaroodi M, Gillevet PM, Xu J, Kisseleva T, Ho SB, DePew J, Du X, Sørensen HT, Vilstrup H, Nelson KE, Brenner D, Fouts DE, Schnabl B. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Nat Commun. 2017 10 16; 8(1):837. PMID: 29038503.
      View in: PubMed
    12. Brenner D. Thomas E. Starzl: Transplantation pioneer. Proc Natl Acad Sci U S A. 2017 Oct 10; 114(41):10808-10809. PMID: 28893997.
      View in: PubMed
    13. Caussy C, Soni M, Cui J, Bettencourt R, Schork N, Chen CH, Ikhwan MA, Bassirian S, Cepin S, Gonzalez MP, Mendler M, Kono Y, Vodkin I, Mekeel K, Haldorson J, Hemming A, Andrews B, Salotti J, Richards L, Brenner D, Sirlin CB, Loomba R. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. J Clin Invest. 2017 Jun 30; 127(7):2697-2704. PMID: 28628033.
      View in: PubMed
    14. Cong M, Zhao W, Liu T, Wang P, Fan X, Zhai Q, Bao X, Zhang D, You H, Kisseleva T, Brenner D, Jia J, Zhuang H. Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. Int J Mol Med. 2017 Aug; 40(2):454-464. PMID: 28627620.
      View in: PubMed
    15. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P, Brenner D. Radiation exposure from depleted uranium: The radiation bystander effect. Toxicol Appl Pharmacol. 2017 09 15; 331:135-141. PMID: 28602947.
      View in: PubMed
    16. Reinders ME, Wardi G, Bettencourt R, Bouland D, Bazick J, Mendler M, Vodkin I, Kalmaz D, Savides T, Brenner D, Sell RE, Loomba R. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. Clin Gastroenterol Hepatol. 2017 Nov; 15(11):1808-1810. PMID: 28602970.
      View in: PubMed
    17. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C, Bettencourt R, Highlander SK, Jones MB, Sirlin CB, Schnabl B, Brinkac L, Schork N, Chen CH, Brenner D, Biggs W, Yooseph S, Venter JC, Nelson KE. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Cell Metab. 2017 May 02; 25(5):1054-1062.e5. PMID: 28467925.
      View in: PubMed
    18. Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V, Kisseleva T, Brenner D, Duffield J, Burkly LC. Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing. Mol Ther Nucleic Acids. 2017 Jun 16; 7:314-323. PMID: 28624207.
      View in: PubMed
    19. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K, Benner C, Heinz S, Bera T, Brenner D, Kisseleva T. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Invest. 2017 Apr 03; 127(4):1254-1270. PMID: 28287406.
      View in: PubMed
    20. Koyama Y, Brenner D. Liver inflammation and fibrosis. J Clin Invest. 2017 Jan 03; 127(1):55-64. PMID: 28045404.
      View in: PubMed
    21. Chapman MA, Mukund K, Subramaniam S, Brenner D, Lieber RL. Three distinct cell populations express extracellular matrix proteins and increase in number during skeletal muscle fibrosis. Am J Physiol Cell Physiol. 2017 Feb 01; 312(2):C131-C143. PMID: 27881411.
      View in: PubMed
    22. Decaris ML, Li KW, Emson CL, Gatmaitan M, Liu S, Wang Y, Nyangau E, Colangelo M, Angel TE, Beysen C, Cui J, Hernandez C, Lazaro L, Brenner D, Turner SM, Hellerstein MK, Loomba R. Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood. Hepatology. 2017 01; 65(1):78-88. PMID: 27706836.
      View in: PubMed
    23. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA, Rizo E, Richards L, Brenner D, Sirlin CB, Loomba R. Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. Gastroenterology. 2017 02; 152(3):598-607.e2. PMID: 27911262.
      View in: PubMed
    24. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K, Richards L, Rizo E, Hernandez C, Kisseleva T, Schnabl B, Brenner D, Sirlin CB, Loomba R. Weight Loss Decreases Magnetic Resonance Elastography Estimated Liver Stiffness in Nonalcoholic Fatty Liver Disease. Clin Gastroenterol Hepatol. 2017 Mar; 15(3):463-464. PMID: 27712981.
      View in: PubMed
    25. Karin D, Koyama Y, Brenner D, Kisseleva T. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. Differentiation. 2016 Sep; 92(3):84-92. PMID: 27591095.
      View in: PubMed
    26. Kim IH, Xu J, Liu X, Koyama Y, Ma HY, Diggle K, You YH, Schilling JM, Jeste D, Sharma K, Brenner D, Kisseleva T. Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. Age (Dordr). 2016 Aug; 38(4):291-302. PMID: 27578257.
      View in: PubMed
    27. Cui J, Chen CH, Lo MT, Schork N, Bettencourt R, Gonzalez MP, Bhatt A, Hooker J, Shaffer K, Nelson KE, Long MT, Brenner D, Sirlin CB, Loomba R. Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study. Hepatology. 2016 11; 64(5):1547-1558. PMID: 27315352.
      View in: PubMed
    28. Koyama Y, Xu J, Liu X, Brenner D. New Developments on the Treatment of Liver Fibrosis. Dig Dis. 2016; 34(5):589-96. PMID: 27332862; PMCID: PMC4961096 [Available on 06/22/17].
    29. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R, Richards L, Salotti J, Bhatt A, Hooker J, Haufe W, Hooker C, Brenner D, Sirlin CB, Loomba R. Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial. J Hepatol. 2016 Aug; 65(2):369-76. PMID: 27151177.
      View in: PubMed
    30. Loomba R, Cui J, Wolfson T, Haufe W, Hooker J, Szeverenyi N, Ang B, Bhatt A, Wang K, Aryafar H, Behling C, Valasek MA, Lin GY, Gamst A, Brenner D, Yin M, Glaser KJ, Ehman RL, Sirlin CB. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. Am J Gastroenterol. 2016 Jul; 111(7):986-94. PMID: 27002798; PMCID: PMC5001170 [Available on 01/01/17].
    31. Brenner D, Müller K, Wieland T, Weydt P, Böhm S, Lulé D, Hübers A, Neuwirth C, Weber M, Borck G, Wahlqvist M, Danzer KM, Volk AE, Meitinger T, Strom TM, Otto M, Kassubek J, Ludolph AC, Andersen PM, Weishaupt JH. NEK1 mutations in familial amyotrophic lateral sclerosis. Brain. 2016 05; 139(Pt 5):e28. PMID: 26945885.
      View in: PubMed
    32. Ma HY, Xu J, Liu X, Zhu Y, Gao B, Karin M, Tsukamoto H, Jeste DV, Grant I, Roberts AJ, Contet C, Geoffroy C, Zheng B, Brenner D, Kisseleva T. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. PMID: 27239399.
      View in: PubMed
    33. Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH, Brenner D, Kisseleva T. Promising Therapy Candidates for Liver Fibrosis. Front Physiol. 2016; 7:47. PMID: 26909046; PMCID: PMC4754444.
    34. Liu X, Brenner D. Liver: DNA methylation controls liver fibrogenesis. Nat Rev Gastroenterol Hepatol. 2016 Mar; 13(3):126-8. PMID: 26860269.
      View in: PubMed
    35. Wang L, Fouts DE, Stärkel P, Hartmann P, Chen P, Llorente C, DePew J, Moncera K, Ho SB, Brenner D, Hooper LV, Schnabl B. Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. Cell Host Microbe. 2016 Feb 10; 19(2):227-39. PMID: 26867181; PMCID: PMC4786170 [Available on 02/10/17].
    36. Liang S, Kisseleva T, Brenner D. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Front Physiol. 2016; 7:17. PMID: 26869935; PMCID: PMC4735448.
    37. Schnabl B, Farshchi-Heydari S, Loomba R, Mattrey RF, Hoh CK, Sirlin CB, Brenner D, Behling CA, Vera DR. Staging of fibrosis in experimental non-alcoholic steatohepatitis by quantitative molecular imaging in rat models. Nucl Med Biol. 2016 Feb; 43(2):179-87. PMID: 26872443.
      View in: PubMed
    38. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS, Brenner D, Qamar AA, Miloh TA, Guarino A, Guslandi M, Dieleman LA, Ringel Y, Quigley EM, Brandt LJ. Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion. J Clin Gastroenterol. 2015 Nov-Dec; 49 Suppl 1:S69-73. PMID: 26447969.
      View in: PubMed
    39. Brenner D, Paik YH, Schnabl B. Role of Gut Microbiota in Liver Disease. J Clin Gastroenterol. 2015 Nov-Dec; 49 Suppl 1:S25-7. PMID: 26447960; PMCID: PMC4602394 [Available on 11/01/16].
    40. Loomba R, Schork N, Chen CH, Bettencourt R, Bhatt A, Ang B, Nguyen P, Hernandez C, Richards L, Salotti J, Lin S, Seki E, Nelson KE, Sirlin CB, Brenner D. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Gastroenterology. 2015 Dec; 149(7):1784-93. PMID: 26299412; PMCID: PMC4663110 [Available on 12/01/16].
    41. Lan T, Kisseleva T, Brenner D. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. PLoS One. 2015; 10(7):e0129743. PMID: 26222337; PMCID: PMC4519306.
    42. Koyama Y, Brenner D. New therapies for hepatic fibrosis. Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S75-9. PMID: 26206573; PMCID: PMC4734896.
    43. Kim IH, Kisseleva T, Brenner D. Aging and liver disease. Curr Opin Gastroenterol. 2015 May; 31(3):184-91. PMID: 25850346; PMCID: PMC4736713.
    44. Seki E, Brenner D. Recent advancement of molecular mechanisms of liver fibrosis. J Hepatobiliary Pancreat Sci. 2015 Jul; 22(7):512-8. PMID: 25869468; PMCID: PMC4668270.
    45. Gao L, Brenner D, Llorens-Bobadilla E, Saiz-Castro G, Frank T, Wieghofer P, Hill O, Thiemann M, Karray S, Prinz M, Weishaupt JH, Martin-Villalba A. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. J Exp Med. 2015 Apr 06; 212(4):469-80. PMID: 25779632; PMCID: PMC4387281.
    46. Loomba R, Sirlin CB, Ang B, Bettencourt R, Jain R, Salotti J, Soaft L, Hooker J, Kono Y, Bhatt A, Hernandez L, Nguyen P, Noureddin M, Haufe W, Hooker C, Yin M, Ehman R, Lin GY, Valasek MA, Brenner D, Richards L. Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). Hepatology. 2015 Apr; 61(4):1239-50. PMID: 25482832; PMCID: PMC4407930.
    47. Xu J, Cong M, Park TJ, Scholten D, Brenner D, Kisseleva T. Contribution of bone marrow-derived fibrocytes to liver fibrosis. Hepatobiliary Surg Nutr. 2015 Feb; 4(1):34-47. PMID: 25713803; PMCID: PMC4318956.
    48. Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner D, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M, Evans RM. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb; 21(2):159-65. PMID: 25559344; PMCID: PMC4320010.
    49. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA, Miyamoto Y, Eckmann L, Dhungana S, Pathmasiri W, Sumner S, Westwater C, Brenner D, Schnabl B. Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice. FASEB J. 2015 Mar; 29(3):1043-55. PMID: 25466902; PMCID: PMC4422368.
    50. Loomba R, Wolfson T, Ang B, Hooker J, Behling C, Peterson M, Valasek M, Lin G, Brenner D, Gamst A, Ehman R, Sirlin C. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. Hepatology. 2014 Dec; 60(6):1920-8. PMID: 25103310; PMCID: PMC4245360.
    51. McArdle PF, Kittner SJ, Ay H, Brown RD, Meschia JF, Rundek T, Wassertheil-Smoller S, Woo D, Andsberg G, Biffi A, Brenner D, Cole JW, Corriveau R, de Bakker PI, Delavaran H, Dichgans M, Grewal RP, Gwinn K, Huq M, Jern C, Jimenez-Conde J, Jood K, Kaplan RC, Katschnig P, Katsnelson M, Labovitz DL, Lemmens R, Li L, Lindgren A, Markus HS, Peddareddygari LR, Pedersén A, Pera J, Redfors P, Roquer J, Rosand J, Rost NS, Rothwell PM, Sacco RL, Sharma P, Slowik A, Sudlow C, Thijs V, Tiedt S, Valenti R, Worrall BB. Agreement between TOAST and CCS ischemic stroke classification: the NINDS SiGN study. Neurology. 2014 Oct 28; 83(18):1653-60. PMID: 25261504.
      View in: PubMed
    52. Xu J, Liu X, Gao B, Karin M, Tsukamoto H, Brenner D, Kisseleva T. New Approaches for Studying Alcoholic Liver Disease. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. PMID: 26594598.
      View in: PubMed
    53. Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA, Hofmann AF, Iida T, Glass CK, Brenner D, Kisseleva T. Origin of myofibroblasts in the fibrotic liver in mice. Proc Natl Acad Sci U S A. 2014 Aug 12; 111(32):E3297-305. PMID: 25074909; PMCID: PMC4136601.
    54. Lopez-Sanchez I, Dunkel Y, Roh YS, Mittal Y, De Minicis S, Muranyi A, Singh S, Shanmugam K, Aroonsakool N, Murray F, Ho SB, Seki E, Brenner D, Ghosh P. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. Nat Commun. 2014 Jul 21; 5:4451. PMID: 25043713; PMCID: PMC4107319.
    55. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner D, Seki E. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014 Aug; 124(8):3566-78. PMID: 24983318; PMCID: PMC4109552.
    56. Moore-Morris T, Guimarães-Camboa N, Banerjee I, Zambon AC, Kisseleva T, Velayoudon A, Stallcup WB, Gu Y, Dalton ND, Cedenilla M, Gomez-Amaro R, Zhou B, Brenner D, Peterson KL, Chen J, Evans SM. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. J Clin Invest. 2014 Jul; 124(7):2921-34. PMID: 24937432; PMCID: PMC4071409.
    57. Brown TM, Voeks JH, Bittner V, Brenner D, Cushman M, Goff DC, Glasser S, Muntner P, Tabereaux PB, Safford MM. Achievement of optimal medical therapy goals for U.S. adults with coronary artery disease: results from the REGARDS Study (REasons for Geographic And Racial Differences in Stroke). J Am Coll Cardiol. 2014 Apr 29; 63(16):1626-33. PMID: 24534599; PMCID: PMC4201851.
    58. Paik YH, Kim J, Aoyama T, De Minicis S, Bataller R, Brenner D. Role of NADPH oxidases in liver fibrosis. Antioxid Redox Signal. 2014 Jun 10; 20(17):2854-72. PMID: 24040957; PMCID: PMC4026397.
    59. Liu C, Chen X, Yang L, Kisseleva T, Brenner D, Seki E. Transcriptional repression of the transforming growth factor ß (TGF-ß) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor ?B (NF-?B) p50 enhances TGF-ß signaling in hepatic stellate cells. J Biol Chem. 2014 Mar 07; 289(10):7082-91. PMID: 24448807; PMCID: PMC3945368.
    60. Schnabl B, Brenner D. Interactions between the intestinal microbiome and liver diseases. Gastroenterology. 2014 May; 146(6):1513-24. PMID: 24440671; PMCID: PMC3996054.
    61. Brenner D. Fra, Fra away: the complex role of activator protein 1 in liver injury. Hepatology. 2014 Jan; 59(1):19-20. PMID: 23904356.
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    62. Brenner D. Reversibility of liver fibrosis. Gastroenterol Hepatol (N Y). 2013 Nov; 9(11):737-9. PMID: 24764791; PMCID: PMC3995196.
    63. Noureddin M, Lam J, Peterson MR, Middleton M, Hamilton G, Le TA, Bettencourt R, Changchien C, Brenner D, Sirlin C, Loomba R. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Hepatology. 2013 Dec; 58(6):1930-40. PMID: 23696515; PMCID: PMC4819962.
    64. Madsen DH, Leonard D, Masedunskas A, Moyer A, Jürgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS, Brenner D, Burgdorf S, Engelholm LH, Behrendt N, Holmbeck K, Weigert R, Bugge TH. M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. J Cell Biol. 2013 Sep 16; 202(6):951-66. PMID: 24019537; PMCID: PMC3776354.
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    66. De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Millán C, Brenner D, Vivarelli M, Mocchegiani F, Marzioni M, Benedetti A, Svegliati-Baroni G. Semaphorin 7A contributes to TGF-ß-mediated liver fibrogenesis. Am J Pathol. 2013 Sep; 183(3):820-30. PMID: 23850082.
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    68. Loomba R, Liu J, Yang HI, Lee MH, Lu SN, Wang LY, Iloeje UH, You SL, Brenner D, Chen CJ. Synergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma. Clin Gastroenterol Hepatol. 2013 Dec; 11(12):1636-45.e1-3. PMID: 23669307; PMCID: PMC4100777.
    69. Loomba R, Doycheva I, Bettencourt R, Cohen B, Wassel CL, Brenner D, Barrett-Connor E. Serum ?-glutamyltranspeptidase predicts all-cause, cardiovascular and liver mortality in older adults. J Clin Exp Hepatol. 2013 Mar 01; 3(1):4-11. PMID: 23997501.
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    72. Miura K, Yang L, van Rooijen N, Brenner D, Ohnishi H, Seki E. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Hepatology. 2013 Feb; 57(2):577-89. PMID: 22987396; PMCID: PMC3566276.
    73. Loomba R, Yang HI, Su J, Brenner D, Barrett-Connor E, Iloeje U, Chen CJ. Synergism between obesity and alcohol in increasing the risk of hepatocellular carcinoma: a prospective cohort study. Am J Epidemiol. 2013 Feb 15; 177(4):333-42. PMID: 23355498; PMCID: PMC3626057.
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    75. Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C, Page P, Brenner D. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology. 2012 Dec; 56(6):2316-27. PMID: 22806357; PMCID: PMC3493679.
    76. De Minicis S, Kisseleva T, Francis H, Baroni GS, Benedetti A, Brenner D, Alvaro D, Alpini G, Marzioni M. Liver carcinogenesis: rodent models of hepatocarcinoma and cholangiocarcinoma. Dig Liver Dis. 2013 Jun; 45(6):450-9. PMID: 23177172; PMCID: PMC3716909.
    77. Brenner D. Next-generation academic medicine. J Clin Invest. 2012 Nov; 122(11):4280-2. PMID: 23114607; PMCID: PMC3484473.
    78. Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E, Brenner D, Apte RN, Jung S, Lapidot T. Monocytes-macrophages that express a-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. Nat Immunol. 2012 Nov; 13(11):1072-82. PMID: 22983360.
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    80. Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T, Welsh DK, Brenner D, Doyle FJ, Schultz PG, Kay SA. Identification of small molecule activators of cryptochrome. Science. 2012 Aug 31; 337(6098):1094-7. PMID: 22798407; PMCID: PMC3589997.
    81. Le TA, Chen J, Changchien C, Peterson MR, Kono Y, Patton H, Cohen BL, Brenner D, Sirlin C, Loomba R. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Hepatology. 2012 Sep; 56(3):922-32. PMID: 22431131; PMCID: PMC3400720.
    82. Schnabl B, Brenner D. Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis. Gut. 2013 Mar; 62(3):335-6. PMID: 22717452; PMCID: PMC4077319.
    83. Seki E, Brenner D, Karin M. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology. 2012 Aug; 143(2):307-20. PMID: 22705006; PMCID: PMC3523093.
    84. Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, Österreicher CH, Stickel F, Ley K, Brenner D, Kisseleva T. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Gastroenterology. 2012 Sep; 143(3):765-776.e3. PMID: 22687286; PMCID: PMC3635475.
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    88. Lee JK, Bettencourt R, Brenner D, Le TA, Barrett-Connor E, Loomba R. Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study. PLoS One. 2012; 7(4):e34218. PMID: 22514624; PMCID: PMC3325993.
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    90. Fouts DE, Torralba M, Nelson KE, Brenner D, Schnabl B. Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease. J Hepatol. 2012 Jun; 56(6):1283-92. PMID: 22326468; PMCID: PMC3357486.
    91. Nelson DR, Teckman J, Di Bisceglie AM, Brenner D. Diagnosis and management of patients with a1-antitrypsin (A1AT) deficiency. Clin Gastroenterol Hepatol. 2012 Jun; 10(6):575-80. PMID: 22200689; PMCID: PMC3360829.
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    93. Paik YH, Brenner D. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. Korean J Hepatol. 2011 Dec; 17(4):251-7. PMID: 22310788; PMCID: PMC3304665.
    94. Dong MH, Bettencourt R, Brenner D, Barrett-Connor E, Loomba R. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. Clin Gastroenterol Hepatol. 2012 Mar; 10(3):285-90.e1. PMID: 22020064; PMCID: PMC3288181.
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    96. Scholten D, Reichart D, Paik YH, Lindert J, Bhattacharya J, Glass CK, Brenner D, Kisseleva T. Migration of fibrocytes in fibrogenic liver injury. Am J Pathol. 2011 Jul; 179(1):189-98. PMID: 21703401; PMCID: PMC3123781.
    97. Paik YH, Iwaisako K, Seki E, Inokuchi S, Schnabl B, Osterreicher CH, Kisseleva T, Brenner D. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Hepatology. 2011 May; 53(5):1730-41. PMID: 21384410; PMCID: PMC3082608.
    98. Kisseleva T, Brenner D. Is it the end of the line for the EMT? Hepatology. 2011 May; 53(5):1433-5. PMID: 21433040.
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    100. Kisseleva T, von Köckritz-Blickwede M, Reichart D, McGillvray SM, Wingender G, Kronenberg M, Glass CK, Nizet V, Brenner D. Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection. J Mol Med (Berl). 2011 Oct; 89(10):997-1013. PMID: 21499735; PMCID: PMC3171633.
    101. Inokuchi S, Tsukamoto H, Park E, Liu ZX, Brenner D, Seki E. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol Clin Exp Res. 2011 Aug; 35(8):1509-18. PMID: 21463341; PMCID: PMC3131439.
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    103. Meng F, Wang J, Ge J, Fan X, Wang B, Han L, Kisseleva T, Paik Y, Brenner D, Wang K. Alteration of interferon-a/ß receptors in chronic hepatitis B patients. J Clin Immunol. 2011 Jun; 31(3):521-32. PMID: 21445562; PMCID: PMC4795458.
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    105. Miura K, Seki E, Ohnishi H, Brenner D. Role of toll-like receptors and their downstream molecules in the development of nonalcoholic Fatty liver disease. Gastroenterol Res Pract. 2010; 2010:362847. PMID: 21274430; PMCID: PMC3026974.
    106. Chau BN, Brenner D. What goes up must come down: the emerging role of microRNA in fibrosis. Hepatology. 2011 Jan; 53(1):4-6. PMID: 21254156.
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    107. Parsons CJ, Stefanovic B, Seki E, Aoyama T, Latour AM, Marzluff WF, Rippe RA, Brenner D. Mutation of the 5'-untranslated region stem-loop structure inhibits a1(I) collagen expression in vivo. J Biol Chem. 2011 Mar 11; 286(10):8609-19. PMID: 21193410; PMCID: PMC3048743.
    108. Österreicher CH, Penz-Österreicher M, Grivennikov SI, Guma M, Koltsova EK, Datz C, Sasik R, Hardiman G, Karin M, Brenner D. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):308-13. PMID: 21173249; PMCID: PMC3017162.
    109. Osawa Y, Seki E, Kodama Y, Suetsugu A, Miura K, Adachi M, Ito H, Shiratori Y, Banno Y, Olefsky JM, Nagaki M, Moriwaki H, Brenner D, Seishima M. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. FASEB J. 2011 Apr; 25(4):1133-44. PMID: 21163859; PMCID: PMC3058702.
    110. Yan AW, Fouts DE, Brandl J, Stärkel P, Torralba M, Schott E, Tsukamoto H, Nelson KE, Brenner D, Schnabl B. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Hepatology. 2011 Jan; 53(1):96-105. PMID: 21254165; PMCID: PMC3059122.
    111. De Minicis S, Seki E, Paik YH, Osterreicher CH, Kodama Y, Kluwe J, Torozzi L, Miyai K, Benedetti A, Schwabe RF, Brenner D. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Hepatology. 2010 Oct; 52(4):1420-30. PMID: 20690191; PMCID: PMC2947612.
    112. Aoyama T, Inokuchi S, Brenner D, Seki E. CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. Hepatology. 2010 Oct; 52(4):1390-400. PMID: 20683935; PMCID: PMC2947579.
    113. Zhang EE, Liu Y, Dentin R, Pongsawakul PY, Liu AC, Hirota T, Nusinow DA, Sun X, Landais S, Kodama Y, Brenner D, Montminy M, Kay SA. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med. 2010 Oct; 16(10):1152-6. PMID: 20852621; PMCID: PMC2952072.
    114. Loomba R, Yang HI, Su J, Brenner D, Iloeje U, Chen CJ. Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. Clin Gastroenterol Hepatol. 2010 Oct; 8(10):891-8, 898.e1-2. PMID: 20621202.
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    117. Loomba R, Rao F, Zhang L, Khandrika S, Ziegler MG, Brenner D, O'Connor DT. Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins. Gastroenterology. 2010 Sep; 139(3):836-45, 845.e1. PMID: 20537997; PMCID: PMC3038676.
    118. Brenner D, Zweifler RM, Gomez CR, Kissela BM, Levine D, Howard G, Coull B, Howard VJ. Awareness, treatment, and control of vascular risk factors among stroke survivors. J Stroke Cerebrovasc Dis. 2010 Jul-Aug; 19(4):311-20. PMID: 20472464; PMCID: PMC3606552.
    119. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H, Olefsky JM, Brenner D, Seki E. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology. 2010 Jul; 139(1):323-34.e7. PMID: 20347818; PMCID: PMC4631262.
    120. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K, Brenner D, Ginès P, Bataller R. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. Hepatology. 2010 Mar; 51(3):942-52. PMID: 20044807.
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    123. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA, Brenner D, Lemasters JJ. Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. Liver Transpl. 2010 Feb; 16(2):181-90. PMID: 20104486; PMCID: PMC2834418.
    124. Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S, Brenner D, Seki E. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):844-9. PMID: 20080763; PMCID: PMC2818947.
    125. Sancho-Bru P, Juez E, Moreno M, Khurdayan V, Morales-Ruiz M, Colmenero J, Arroyo V, Brenner D, Ginès P, Bataller R. Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells. Liver Int. 2010 Jan; 30(1):31-41. PMID: 19929904.
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    127. Brafman DA, de Minicis S, Seki E, Shah KD, Teng D, Brenner D, Willert K, Chien S. Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Integr Biol (Camb). 2009 Sep; 1(8-9):513-24. PMID: 20023766.
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    128. Colmenero J, Bataller R, Sancho-Bru P, Domínguez M, Moreno M, Forns X, Bruguera M, Arroyo V, Brenner D, Ginès P. Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Am J Physiol Gastrointest Liver Physiol. 2009 Oct; 297(4):G726-34. PMID: 19628656; PMCID: PMC2763804.
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    134. Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA, Brenner D, Milne GL, Morrow JD, Boutaud O, Oates JA. The enteropathy of prostaglandin deficiency. J Gastroenterol. 2009; 44 Suppl 19:1-7. PMID: 19148786; PMCID: PMC2799331.
    135. Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y, Brenner D. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. Gastroenterology. 2009 Apr; 136(4):1423-34. PMID: 19249395.
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    138. De Minicis S, Seki E, Oesterreicher C, Schnabl B, Schwabe RF, Brenner D. Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. Hepatology. 2008 Dec; 48(6):2016-26. PMID: 19025999.
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    139. Lin SL, Kisseleva T, Brenner D, Duffield JS. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol. 2008 Dec; 173(6):1617-27. PMID: 19008372; PMCID: PMC2626374.
    140. Gäbele E, Froh M, Arteel GE, Uesugi T, Hellerbrand C, Schölmerich J, Brenner D, Thurman RG, Rippe RA. TNFalpha is required for cholestasis-induced liver fibrosis in the mouse. Biochem Biophys Res Commun. 2009 Jan 16; 378(3):348-53. PMID: 18996089.
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    141. Miura K, Taura K, Kodama Y, Schnabl B, Brenner D. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Hepatology. 2008 Nov; 48(5):1420-9. PMID: 18671304.
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    142. Notas G, Kisseleva T, Brenner D. NK and NKT cells in liver injury and fibrosis. Clin Immunol. 2009 Jan; 130(1):16-26. PMID: 18823822.
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    144. Schnabl B, Scholten D, Brenner D. What is the potential role of antifibrotic agents for the treatment of liver disease? Nat Clin Pract Gastroenterol Hepatol. 2008 Sep; 5(9):496-7. PMID: 18628735.
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    145. Seki E, Brenner D. Toll-like receptors and adaptor molecules in liver disease: update. Hepatology. 2008 Jul; 48(1):322-35. PMID: 18506843.
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    146. Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA, Brenner D, Morrow JD, Boutaud O, Oates JA. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. J Clin Invest. 2008 Jun; 118(6):2121-31. PMID: 18451993; PMCID: PMC2350426.
    147. Purohit V, Bode JC, Bode C, Brenner D, Choudhry MA, Hamilton F, Kang YJ, Keshavarzian A, Rao R, Sartor RB, Swanson C, Turner JR. Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. Alcohol. 2008 Aug; 42(5):349-61. PMID: 18504085.
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    148. Brenner D, Labreuche J, Pico F, Scheltens P, Poirier O, Cambien F, Amarenco P. The renin-angiotensin-aldosterone system in cerebral small vessel disease. J Neurol. 2008 Jul; 255(7):993-1000. PMID: 18446309.
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    154. Brenner D, Alexandrov AV. Alzheimer's disease: the vascular connection. Int J Stroke. 2007 Nov; 2(4):243-4. PMID: 18705924.
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    155. Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner D, Schwabe RF. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med. 2007 Nov; 13(11):1324-32. PMID: 17952090.
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    156. Sancho-Bru P, Bataller R, Fernandez-Varo G, Moreno M, Ramalho LN, Colmenero J, Marí M, Clària J, Jiménez W, Arroyo V, Brenner D, Ginès P. Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. Gastroenterology. 2007 Dec; 133(6):2019-28. PMID: 18054572.
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    157. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y, Brenner D, Watanabe S. Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB. J Hepatol. 2007 Dec; 47(6):834-43. PMID: 17935821.
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    158. Sachs RK, Shuryak I, Brenner D, Fakir H, Hlatky L, Hahnfeldt P. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. J Theor Biol. 2007 Dec 07; 249(3):518-31. PMID: 17897680; PMCID: PMC2169295.
    159. Tacke F, Trautwein C, Yagmur E, Hellerbrand C, Wiest R, Brenner D, Schnabl B. Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course. J Gastroenterol Hepatol. 2007 Aug; 22(8):1256-64. PMID: 17688666.
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    160. Schwabe RF, Brenner D. Nuclear factor-kappaB in the liver: friend or foe? Gastroenterology. 2007 Jun; 132(7):2601-4. PMID: 17570232.
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    161. Kisseleva T, Brenner D. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. J Gastroenterol Hepatol. 2007 Jun; 22 Suppl 1:S73-8. PMID: 17567473.
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    162. Seki E, Brenner D. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? J Hepatol. 2007 Aug; 47(2):307-9. PMID: 17566588; PMCID: PMC2739234.
    163. De Minicis S, Brenner D. NOX in liver fibrosis. Arch Biochem Biophys. 2007 Jun 15; 462(2):266-72. PMID: 17531188; PMCID: PMC2727549.
    164. Kaplan LM, Klein S, Boden G, Brenner D, Gostout CJ, Lavine JE, Popkin BM, Schirmer BD, Seeley RJ, Yanovski SZ, Cominelli F. Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force. Gastroenterology. 2007 May; 132(6):2272-5. PMID: 17498517.
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    165. Tacke F, Gäbele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C, Brenner D, Schölmerich J, Schnabl B. Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. Dig Dis Sci. 2007 Dec; 52(12):3404-15. PMID: 17415633.
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    166. Osterreicher CH, Brenner D. The genetics of nonalcoholic fatty liver disease. Ann Hepatol. 2007 Apr-Jun; 6(2):83-8. PMID: 17519829.
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    167. De Minicis S, Seki E, Uchinami H, Kluwe J, Zhang Y, Brenner D, Schwabe RF. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology. 2007 May; 132(5):1937-46. PMID: 17484886.
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    168. Osterreicher CH, Stickel F, Brenner D. Genomics of liver fibrosis and cirrhosis. Semin Liver Dis. 2007 Feb; 27(1):28-43. PMID: 17295175.
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    169. Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D, Brenner D. The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. Gastroenterology. 2007 Apr; 132(4):1434-46. PMID: 17408630.
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    170. Osawa Y, Seki E, Adachi M, Taura K, Kodama Y, Siegmund SV, Schwabe RF, Brenner D. Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. Liver Int. 2006 Nov; 26(9):1138-47. PMID: 17032415.
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    171. Kisseleva T, Brenner D. Hepatic stellate cells and the reversal of fibrosis. J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S84-7. PMID: 16958681.
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    172. Paik YH, Brenner D. Immunosuppression, hepatitis B virus variants: Synergistic role in hepatic fibrogenesis. Gastroenterology. 2006 Sep; 131(3):957-60. PMID: 16952565.
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    173. Crowley W, Courtney J, Jameson L, Pardes H, Moskowitz J, Orringer E, Rubenstein A, Wood A, Rettig R, Ausiello D, Brenner D, Collins F, Elias J, Greene W, Horowitz R, Jameson L, Kieff E, Thompson C, Swain JL. The Clinical Research Forum and Association of American Physicians disagree with criticism of the NIH Roadmap. J Clin Invest. 2006 Aug; 116(8):2058-9. PMID: 16886049; PMCID: PMC1523419.
    174. Uchinami H, Seki E, Brenner D, D'Armiento J. Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis. Hepatology. 2006 Aug; 44(2):420-9. PMID: 16871591.
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    175. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H, Brenner D, Lemasters JJ. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. Transplantation. 2006 Jul 27; 82(2):241-50. PMID: 16858288.
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    176. De Minicis S, Bataller R, Brenner D. NADPH oxidase in the liver: defensive, offensive, or fibrogenic? Gastroenterology. 2006 Jul; 131(1):272-5. PMID: 16831609.
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    177. Sancho-Bru P, Bataller R, Colmenero J, Gasull X, Moreno M, Arroyo V, Brenner D, Ginès P. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2006 Nov; 291(5):G877-84. PMID: 16782692.
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    178. Kisseleva T, Uchinami H, Feirt N, Quintana-Bustamante O, Segovia JC, Schwabe RF, Brenner D. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. J Hepatol. 2006 Sep; 45(3):429-38. PMID: 16846660.
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    179. Brenner D, Labreuche J, Touboul PJ, Schmidt-Petersen K, Poirier O, Perret C, Schönfelder J, Combadière C, Lathrop M, Cambien F, Brand-Herrmann SM, Amarenco P. Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients. Stroke. 2006 Jul; 37(7):1691-6. PMID: 16741188.
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    180. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N, Seki E, Brenner D, Korenblat K, McCrea J. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Gastroenterology. 2006 May; 130(6):1564-72. PMID: 16697719.
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    181. Brenner D. The future of gastroenterology and gastroenterology. Gastroenterology. 2006 May; 130(6):1562. PMID: 16697718.
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    182. Schwabe RF, Seki E, Brenner D. Toll-like receptor signaling in the liver. Gastroenterology. 2006 May; 130(6):1886-900. PMID: 16697751.
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    183. Paik YH, Lee KS, Lee HJ, Yang KM, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Moon YM, Brenner D. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. Lab Invest. 2006 Jul; 86(7):676-86. PMID: 16619004.
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    184. Lehnert M, Uehara T, Bradford BU, Lind H, Zhong Z, Brenner D, Marzi I, Lemasters JJ. Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation. Am J Physiol Gastrointest Liver Physiol. 2006 Sep; 291(3):G456-63. PMID: 16614372.
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    185. Lehmann TG, Luedde T, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ, Brenner D. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. Liver Transpl. 2006 Apr; 12(4):550-9. PMID: 16555330.
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    186. Schwabe RF, Brenner D. Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol. 2006 Apr; 290(4):G583-9. PMID: 16537970.
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    187. Purohit V, Brenner D. Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium. Hepatology. 2006 Apr; 43(4):872-8. PMID: 16502397.
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    188. Osawa Y, Hannun YA, Proia RL, Brenner D. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Hepatology. 2005 Dec; 42(6):1320-8. PMID: 16317686.
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    189. Siegmund SV, Brenner D. Molecular pathogenesis of alcohol-induced hepatic fibrosis. Alcohol Clin Exp Res. 2005 Nov; 29(11 Suppl):102S-109S. PMID: 16344593.
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    190. Schnabl B, Hu K, Mühlbauer M, Hellerbrand C, Stefanovic B, Brenner D, Schölmerich J. Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. Biochem Biophys Res Commun. 2005 Sep 16; 335(1):87-96. PMID: 16054593.
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    191. Stefanovic L, Brenner D, Stefanovic B. Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. Exp Biol Med (Maywood). 2005 Sep; 230(8):573-86. PMID: 16118408.
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    192. Bataller R, Sancho-Bru P, Ginès P, Brenner D. Liver fibrogenesis: a new role for the renin-angiotensin system. Antioxid Redox Signal. 2005 Sep-Oct; 7(9-10):1346-55. PMID: 16115040.
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    193. Yang L, Bataller R, Dulyx J, Coffman TM, Ginès P, Rippe RA, Brenner D. Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. J Hepatol. 2005 Aug; 43(2):317-23. PMID: 15964094.
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    194. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA, Brenner D. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem. 2005 Jul 29; 280(30):27879-87. PMID: 15946935.
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    195. Yang L, Magness ST, Bataller R, Rippe RA, Brenner D. NF-kappaB activation in Kupffer cells after partial hepatectomy. Am J Physiol Gastrointest Liver Physiol. 2005 Sep; 289(3):G530-8. PMID: 15905413.
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    196. Bataller R, Gäbele E, Parsons CJ, Morris T, Yang L, Schoonhoven R, Brenner D, Rippe RA. Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats. Hepatology. 2005 May; 41(5):1046-55. PMID: 15841463.
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    197. Siegmund SV, Uchinami H, Osawa Y, Brenner D, Schwabe RF. Anandamide induces necrosis in primary hepatic stellate cells. Hepatology. 2005 May; 41(5):1085-95. PMID: 15841466.
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    198. Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R, Brenner D, Tabas I. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. J Biol Chem. 2005 Jun 10; 280(23):21763-72. PMID: 15826936.
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    199. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK, Brenner D. JNK mediates hepatic ischemia reperfusion injury. J Hepatol. 2005 Jun; 42(6):850-9. PMID: 15885356.
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    200. Luedde T, Assmus U, Wüstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K, Brenner D, Manns MP, Pasparakis M, Trautwein C. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J Clin Invest. 2005 Apr; 115(4):849-59. PMID: 15776110; PMCID: PMC1064982.
    201. Modlin IM, Adler G, Alexander K, Arnold R, Brenner D, Corazziari E, Floch MH, LaPorte RE, Peterson WL, Quigley EM, Shapiro MD, Spechler SJ, Spiller RC, Tytgat GN, Wiegers W. Information assimilation and distribution challenges and goals for real and virtual journals. J Clin Gastroenterol. 2005 Mar; 39(3):181-8. PMID: 15718859.
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    202. Bataller R, Brenner D. Liver fibrosis. J Clin Invest. 2005 Feb; 115(2):209-18. PMID: 15690074; PMCID: PMC546435.
    203. Gäbele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW, Brenner D, Rippe RA. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. J Biol Chem. 2005 Apr 08; 280(14):13374-82. PMID: 15677443.
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    204. Siegmund SV, Dooley S, Brenner D. Molecular mechanisms of alcohol-induced hepatic fibrosis. Dig Dis. 2005; 23(3-4):264-74. PMID: 16508291.
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    205. Adachi M, Brenner D. Clinical syndromes of alcoholic liver disease. Dig Dis. 2005; 23(3-4):255-63. PMID: 16508290.
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    206. Brenner D. Data from arrays: an embarrassment of riches. Gastroenterology. 2004 Dec; 127(6):1659. PMID: 15578500.
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    207. Magness ST, Bataller R, Yang L, Brenner D. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Hepatology. 2004 Nov; 40(5):1151-9. PMID: 15389867.
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    208. Parsons CJ, Bradford BU, Pan CQ, Cheung E, Schauer M, Knorr A, Krebs B, Kraft S, Zahn S, Brocks B, Feirt N, Mei B, Cho MS, Ramamoorthi R, Roldan G, Ng P, Lum P, Hirth-Dietrich C, Tomkinson A, Brenner D. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Hepatology. 2004 Nov; 40(5):1106-15. PMID: 15389776.
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    209. Rippe RA, Brenner D. From quiescence to activation: Gene regulation in hepatic stellate cells. Gastroenterology. 2004 Oct; 127(4):1260-2. PMID: 15481004.
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    210. Harada N, Hatano E, Koizumi N, Nitta T, Yoshida M, Yamamoto N, Brenner D, Yamaoka Y. Akt activation protects rat liver from ischemia/reperfusion injury. J Surg Res. 2004 Oct; 121(2):159-70. PMID: 15501455.
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    211. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R, Brenner D, Lemasters J. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Transplantation. 2004 Aug 15; 78(3):324-32. PMID: 15316358.
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    212. Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE, Brenner D, Jobin C. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. J Immunol. 2004 Aug 01; 173(3):1561-70. PMID: 15265883.
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    213. Black D, Bird MA, Hayden M, Schrum LW, Lange P, Samson C, Hatano E, Rippe RA, Brenner D, Behrns KE. TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein. Surgery. 2004 Jun; 135(6):619-28. PMID: 15179368.
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    214. Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ, Brenner D, Rippe RA, Behrns KE. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. J Hepatol. 2004 Jun; 40(6):942-51. PMID: 15158334.
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    215. Lindquist JN, Parsons CJ, Stefanovic B, Brenner D. Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region. J Biol Chem. 2004 May 28; 279(22):23822-9. PMID: 14973140.
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    216. Schwabe RF, Uchinami H, Qian T, Bennett BL, Lemasters JJ, Brenner D. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. FASEB J. 2004 Apr; 18(6):720-2. PMID: 14766793.
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    217. Bataller R, Paik YH, Lindquist JN, Lemasters JJ, Brenner D. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology. 2004 Feb; 126(2):529-40. PMID: 14762790.
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    218. Stefanovic B, Stefanovic L, Schnabl B, Bataller R, Brenner D. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Mol Cell Biol. 2004 Feb; 24(4):1758-68. PMID: 14749390; PMCID: PMC344171.
    219. Brenner D. Gastrointestinal basic science 2002-2003: the year in review. Clin Gastroenterol Hepatol. 2004 Jan; 2(1):9-13. PMID: 15017626.
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    220. Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ, Brenner D. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest. 2003 Nov; 112(9):1383-94. PMID: 14597764; PMCID: PMC228420.
    221. Imose M, Nagaki M, Naiki T, Osawa Y, Brenner D, Asano T, Hayashi H, Kato T, Moriwaki H. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. Liver Int. 2003 Oct; 23(5):386-96. PMID: 14708901.
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    222. Brown RS, Brenner D. MELD and the practicing gastroenterologist. Gastroenterology. 2003 Oct; 125(4):1009. PMID: 14517781.
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    223. Lehmann TG, Wheeler MD, Froh M, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ, Brenner D, Thurman RG. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. Transplantation. 2003 Jul 15; 76(1):28-37. PMID: 12865782.
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    224. Kweon YO, Paik YH, Schnabl B, Qian T, Lemasters JJ, Brenner D. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. J Hepatol. 2003 Jul; 39(1):38-46. PMID: 12821042.
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    225. Schwabe RF, Bataller R, Brenner D. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. Am J Physiol Gastrointest Liver Physiol. 2003 Nov; 285(5):G949-58. PMID: 12829440.
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    226. Bataller R, Gäbele E, Schoonhoven R, Morris T, Lehnert M, Yang L, Brenner D, Rippe RA. Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver. Am J Physiol Gastrointest Liver Physiol. 2003 Sep; 285(3):G642-51. PMID: 12773299.
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    227. Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C, Brenner D. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology. 2003 May; 37(5):1043-55. PMID: 12717385.
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    228. Osawa Y, Nagaki M, Banno Y, Brenner D, Nozawa Y, Moriwaki H, Nakashima S. Expression of the NF-kappa B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activation. J Immunol. 2003 Apr 15; 170(8):4053-60. PMID: 12682234.
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    229. Oh KW, Qian T, Brenner D, Lemasters JJ. Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition. Toxicol Sci. 2003 May; 73(1):44-52. PMID: 12700412.
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    230. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R, Brenner D. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology. 2003 Apr; 37(4):824-32. PMID: 12668975.
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    231. Luedde T, Rodriguez ME, Tacke F, Xiong Y, Brenner D, Trautwein C. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Hepatology. 2003 Apr; 37(4):833-41. PMID: 12668976.
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    232. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T, Brenner D, Yamaoka Y. Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. J Hepatol. 2003 Apr; 38(4):468-75. PMID: 12663239.
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    233. Morgan TR, Brenner D, Everhart J, French SW, Fried MW, Gretch DR, Koziel MJ, McClain CJ, Peters MG, Weinman SA, Lucas DL. Hepatitis C and alcohol: fundamental and translational research directions. Alcohol Clin Exp Res. 2003 Apr; 27(4):726-31. PMID: 12711937.
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    234. Bataller R, North KE, Brenner D. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. Hepatology. 2003 Mar; 37(3):493-503. PMID: 12601343.
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    235. Schnabl B, Purbeck CA, Choi YH, Hagedorn CH, Brenner D. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. Hepatology. 2003 Mar; 37(3):653-64. PMID: 12601363.
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    236. Iimuro Y, Nishio T, Morimoto T, Nitta T, Stefanovic B, Choi SK, Brenner D, Yamaoka Y. Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat. Gastroenterology. 2003 Feb; 124(2):445-58. PMID: 12557150.
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    237. Yata Y, Scanga A, Gillan A, Yang L, Reif S, Breindl M, Brenner D, Rippe RA. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Hepatology. 2003 Feb; 37(2):267-76. PMID: 12540776.
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    238. Gäbele E, Brenner D, Rippe RA. Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. Front Biosci. 2003 Jan 01; 8:d69-77. PMID: 12456323.
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    239. Reif S, Lang A, Lindquist JN, Yata Y, Gabele E, Scanga A, Brenner D, Rippe RA. The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression. J Biol Chem. 2003 Mar 07; 278(10):8083-90. PMID: 12502711.
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    240. Kim YS, Schwabe RF, Qian T, Lemasters JJ, Brenner D. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. Hepatology. 2002 Dec; 36(6):1498-508. PMID: 12447876.
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    241. Osawa Y, Nagaki M, Banno Y, Brenner D, Asano T, Nozawa Y, Moriwaki H, Nakashima S. Tumor necrosis factor alpha-induced interleukin-8 production via NF-kappaB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes. Infect Immun. 2002 Nov; 70(11):6294-301. PMID: 12379708; PMCID: PMC130316.
    242. Lemasters JJ, Qian T, He L, Kim JS, Elmore SP, Cascio WE, Brenner D. Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. Antioxid Redox Signal. 2002 Oct; 4(5):769-81. PMID: 12470504.
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    243. Samson CM, Schrum LW, Bird MA, Lange PA, Brenner D, Rippe RA, Behrns KE. Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism. Surgery. 2002 Sep; 132(3):441-9. PMID: 12324757.
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    244. Brenner D, Camilleri M. Joint statement on missions and submissions of papers to AGA journals. Gastroenterology. 2002 Sep; 123(3):877-8. PMID: 12198713.
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    245. Magness ST, Maeda N, Brenner D. An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. Blood. 2002 Aug 15; 100(4):1470-7. PMID: 12149233.
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    246. Liedtke C, Plümpe J, Kubicka S, Bradham CA, Manns MP, Brenner D, Trautwein C. Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. Hepatology. 2002 Aug; 36(2):315-25. PMID: 12143039.
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    247. Schwabe RF, Brenner D. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2002 Jul; 283(1):G204-11. PMID: 12065308.
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