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David Brenner

Title(s)Vice Chancellor - Health Sciences, School of Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0602
La Jolla CA 92093
Phone858-534-1501
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    Other Positions
    Title(s)Dean - School of Medicine


    Collapse Biography 
    Collapse Education and Training
    UC San DiegoFellowship1988Gastroenterology
    NIH/NIDDK, Bethesda, MDFellowship1986Genetics & Biochemistry
    Yale UniversityIntern & Residency1985Internal Medicine
    Yale UniversityMD1979Medicine
    Yale UniversityBS1975Biology

    Collapse Research 
    Collapse Research Activities and Funding
    Microbiome as Therapeutic Target in Alcoholic Hepatitis
    NIH/NIAAA U01AA021856Jun 1, 2013 - May 31, 2018
    Role: Principal Investigator
    The Role of Inflammation and Stroma in Digestive Cancer
    NIH U54CA126513Sep 30, 2006 - Sep 21, 2011
    Role: Co-Investigator
    Angiotensin II and NADPH Oxidase in Hepatic Fibrosis
    NIH/NIDDK R01DK072237Sep 15, 2005 - Jun 30, 2011
    Role: Principal Investigator
    Hepatic Stellate Cell Activation induced by Hepatitis C Virus
    NIH/NIAAA R01AA015055Sep 30, 2003 - Aug 31, 2009
    Role: Principal Investigator
    Cond. Acceptance Post-Bac. Prog. Scholarship Fund
    NIH/NIMHD S22MD000227Sep 30, 2002 - Sep 29, 2005
    Role: Principal Investigator
    Molecular Pathogenesis of Apoptosis in Liver Cells
    NIH P01DK059340Sep 21, 2001 - May 31, 2006
    Role: Co-Investigator
    ONCOGENIC K-RAS INDUCTION OF GASTRIN GENE TRANSCRIPTION
    NIH/NIDDK R01DK055686Aug 15, 2000 - Jul 31, 2006
    Role: Principal Investigator
    GENE TECHNOLOGY THERAPY AND ALCOHOL-INDUCED FIBROSIS
    NIH/NIAAA R01AA012586Sep 23, 1999 - Jun 30, 2003
    Role: Principal Investigator
    The Southern California Research Center for ALPD and Cirrhosis
    NIH/NIAAA P50AA011999Jan 1, 1999 - Jun 30, 2011
    Role: Co-Investigator
    Molecular and Cellular Pathogenesis in Alcoholism
    NIH P60AA011605Dec 1, 1997 - Nov 30, 2017
    Role: Co-Investigator
    MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM
    NIH P50AA011605Dec 1, 1997 - Nov 30, 2002
    Role: Co-Investigator
    RAT MODEL OF ALCOHOLIC PANCREATITIS
    NIH/NIAAA R03AA011226Apr 1, 1997 - Mar 31, 1999
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000827Jan 27, 1997 - Nov 30, 2010
    Role: Principal Investigator
    Gastroenterology Research Training
    NIH/NIDDK T32DK007737Aug 1, 1996 - Jun 30, 2021
    Role: Principal Investigator
    FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS
    NIH/NCI P01CA050528Feb 1, 1996 - Mar 31, 1997
    Role: Co-Investigator
    GENE THERAPY FOR LIVER DISEASES
    NIH/NIDDK R13DK047627Jan 20, 1994 - Oct 31, 1994
    Role: Principal Investigator
    MOLECULAR DEFECTS IN PROTOPORPHYRIA
    NIH/NIDDK R01DK047361May 1, 1993 - May 31, 2004
    Role: Principal Investigator
    Integrated Center for InVivo Microscopy
    NIH P41RR005959Sep 1, 1990 - Jun 30, 2013
    Role: Co-Investigator
    Molecular Mechanisms by which TNFalpha Modulates Fibrosis
    NIH/NIGMS R01GM041804Apr 1, 1989 - Sep 29, 1992
    Role: Principal Investigator
    MOLECULAR DEFECT IN PROTOPORPHYRIA
    NIH/NIDDK R29DK039996Apr 1, 1988 - Mar 31, 1993
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Inhibition of Prolyl Hydroxylases Increases Hepatic Insulin And Decreases Glucagon Sensitivity by An HIF-2a-Dependent Mechanism. Mol Metab. 2020 Jun 10; 101039. Riopel M, Moon JS, Bandyopadhyay GK, You S, Lam K, Liu X, Kisseleva T, Brenner D, Lee YS. PMID: 32534258.
      View in: PubMed   Mentions:    Fields:    
    2. Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis. PLoS One. 2020; 15(6):e0234038. Baeza-Raja B, Goodyear A, Liu X, Lam K, Yamamoto L, Li Y, Dodson GS, Takeuchi T, Kisseleva T, Brenner DA, Dabbagh K. PMID: 32492075.
      View in: PubMed   Mentions:    Fields:    
    3. Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). Medicina (Kaunas). 2020 May 05; 56(5). Pizza V, Antonini P, Marino R, D'Arena G, Lucibello SG, Rizzo M, Brenner DA, Jeste DV, Somma SD. PMID: 32380778.
      View in: PubMed   Mentions:    Fields:    
    4. Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. Front Physiol. 2020; 11:370. Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L, Loomba R, Brenner DA, Stärkel P, Schnabl B. PMID: 32390870.
      View in: PubMed   Mentions:
    5. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. PLoS One. 2020; 15(3):e0229445. Zhang M, Haughey M, Wang NY, Blease K, Kapoun AM, Couto S, Belka I, Hoey T, Groza M, Hartke J, Bennett B, Cain J, Gurney A, Benish B, Castiglioni P, Drew C, Lachowicz J, Carayannopoulos L, Nathan SD, Distler J, Brenner DA, Hariharan K, Cho H, Xie W. PMID: 32160239.
      View in: PubMed   Mentions:    Fields:    
    6. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. JCI Insight. 2020 Feb 13; 5(3). Xu J, Ma HY, Liu X, Rosenthal S, Baglieri J, McCubbin R, Sun M, Koyama Y, Geoffroy CG, Saijo K, Shang L, Nishio T, Maricic I, Kreifeldt M, Kusumanchi P, Roberts A, Zheng B, Kumar V, Zengler K, Pizzo DP, Hosseini M, Contet C, Glass CK, Liangpunsakul S, Tsukamoto H, Gao B, Karin M, Brenner DA, Koob GF, Kisseleva T. PMID: 32051339.
      View in: PubMed   Mentions:    Fields:    
    7. Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. Hepatol Commun. 2020 Apr; 4(4):606-626. Liu X, Rosenthal SB, Meshgin N, Baglieri J, Musallam SG, Diggle K, Lam K, Wu R, Pan SQ, Chen Y, Dorko K, Presnell S, Benner C, Hosseini M, Tsukamoto H, Brenner D, Kisseleva T. PMID: 32258954.
      View in: PubMed   Mentions:
    8. Cardiovascular health of nonagenarians in southern Italy: a cross-sectional, home-based pilot study of longevity. J Cardiovasc Med (Hagerstown). 2020 Feb; 21(2):89-98. Daniels LB, Antonini P, Marino R, Rizzo M, Navarin S, Lucibello SG, Maisel AS, Pizza V, Brenner DA, Jeste DV, Di Somma S. PMID: 31789688.
      View in: PubMed   Mentions: 1     Fields:    
    9. Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution. Gastroenterology. 2020 May; 158(6):1728-1744.e14. Liu X, Xu J, Rosenthal S, Zhang LJ, McCubbin R, Meshgin N, Shang L, Koyama Y, Ma HY, Sharma S, Heinz S, Glass CK, Benner C, Brenner DA, Kisseleva T. PMID: 31982409.
      View in: PubMed   Mentions: 1     Fields:    
    10. Mechanisms of liver fibrosis and its role in liver cancer. Exp Biol Med (Maywood). 2020 Jan; 245(2):96-108. Dhar D, Baglieri J, Kisseleva T, Brenner DA. PMID: 31924111.
      View in: PubMed   Mentions:    Fields:    
    11. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol. 2020 May; 72(5):946-959. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. PMID: 31899206.
      View in: PubMed   Mentions:    Fields:    
    12. Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Cell Metab. 2020 Jan 07; 31(1):189-206.e8. Sun X, Seidman JS, Zhao P, Troutman TD, Spann NJ, Que X, Zhou F, Liao Z, Pasillas M, Yang X, Magida JA, Kisseleva T, Brenner DA, Downes M, Evans RM, Saltiel AR, Tsimikas S, Glass CK, Witztum JL. PMID: 31761566.
      View in: PubMed   Mentions:    Fields:    
    13. The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease. Cell Metab. 2019 11 05; 30(5):850-852. Kisseleva T, Brenner DA. PMID: 31693880.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    14. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Cell Metab. 2019 Sep 03; 30(3):607. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C, Bettencourt R, Highlander SK, Jones MB, Sirlin CB, Schnabl B, Brinkac L, Schork N, Chen CH, Brenner DA, Biggs W, Yooseph S, Venter JC, Nelson KE. PMID: 31484056.
      View in: PubMed   Mentions: 3     Fields:    
    15. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Proc Natl Acad Sci U S A. 2019 07 23; 116(30):15184-15193. Wang L, Mazagova M, Pan C, Yang S, Brandl K, Liu J, Reilly SM, Wang Y, Miao Z, Loomba R, Lu N, Guo Q, Liu J, Yu RT, Downes M, Evans RM, Brenner DA, Saltiel AR, Beutler B, Schnabl B. PMID: 31289229.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    16. Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice. J Hepatol. 2019 09; 71(3):573-585. Nishio T, Hu R, Koyama Y, Liang S, Rosenthal SB, Yamamoto G, Karin D, Baglieri J, Ma HY, Xu J, Liu X, Dhar D, Iwaisako K, Taura K, Brenner DA, Kisseleva T. PMID: 31071368.
      View in: PubMed   Mentions: 2     Fields:    
    17. Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography. Hepatology. 2019 07; 70(1):127-141. Caussy C, Bhargava M, Villesen IF, Gudmann NS, Leeming DJ, Karsdal MA, Faulkner C, Bao D, Liu A, Lo MT, Bettencourt R, Bassirian S, Richards L, Brenner DA, Chen CH, Sirlin CB, Loomba R. PMID: 30859582.
      View in: PubMed   Mentions:    Fields:    
    18. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. Int J Mol Sci. 2019 Apr 07; 20(7). Baglieri J, Brenner DA, Kisseleva T. PMID: 30959975.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    19. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Nat Commun. 2019 03 29; 10(1):1406. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R, Rizo E, Richards L, Xu ZZ, Downes MR, Evans RM, Brenner DA, Sirlin CB, Knight R, Loomba R. PMID: 30926798.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    20. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. J Exp Med. 2019 02 04; 216(2):267-278. Brenner D, Sieverding K, Bruno C, Lüningschrör P, Buck E, Mungwa S, Fischer L, Brockmann SJ, Ulmer J, Bliederhäuser C, Philibert CE, Satoh T, Akira S, Boillée S, Mayer B, Sendtner M, Ludolph AC, Danzer KM, Lobsiger CS, Freischmidt A, Weishaupt JH. PMID: 30635357.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    21. Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease. Gut. 2019 10; 68(10):1884-1892. Caussy C, Ajmera VH, Puri P, Hsu CL, Bassirian S, Mgdsyan M, Singh S, Faulkner C, Valasek MA, Rizo E, Richards L, Brenner DA, Sirlin CB, Sanyal AJ, Loomba R. PMID: 30567742.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    22. Combatting Fibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis. Hepatol Commun. 2019 Feb; 3(2):180-192. Chen L, Brenner DA, Kisseleva T. PMID: 30766956.
      View in: PubMed   Mentions:
    23. Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD. Aliment Pharmacol Ther. 2019 01; 49(2):183-193. Caussy C, Hsu C, Singh S, Bassirian S, Kolar J, Faulkner C, Sinha N, Bettencourt R, Gara N, Valasek MA, Schnabl B, Richards L, Brenner DA, Hofmann AF, Loomba R. PMID: 30506692.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    24. Publisher Correction: The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol. 2018 12; 15(12):785. Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R. PMID: 29785003.
      View in: PubMed   Mentions:    Fields:    
    25. Of Mice and Men and Nonalcoholic Steatohepatitis. Hepatology. 2018 12; 68(6):2059-2061. Brenner DA. PMID: 30033687.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Gastroenterology. 2019 03; 156(4):1156-1172.e6. Liang S, Ma HY, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T, Brenner DA. PMID: 30445007.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    27. Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians. Clin Gastroenterol Hepatol. 2019 01; 17(2):218-230. Allaband C, McDonald D, Vázquez-Baeza Y, Minich JJ, Tripathi A, Brenner DA, Loomba R, Smarr L, Sandborn WJ, Schnabl B, Dorrestein P, Zarrinpar A, Knight R. PMID: 30240894.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    28. The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol. 2018 07; 15(7):397-411. Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R. PMID: 29748586.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    29. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. Hepatology. 2018 09; 68(3):918-932. Caussy C, Hsu C, Lo MT, Liu A, Bettencourt R, Ajmera VH, Bassirian S, Hooker J, Sy E, Richards L, Schork N, Schnabl B, Brenner DA, Sirlin CB, Chen CH, Loomba R. PMID: 29572891.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    30. Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2. Hepatology. 2018 09; 68(3):1070-1086. Lan T, Li C, Yang G, Sun Y, Zhuang L, Ou Y, Li H, Wang G, Kisseleva T, Brenner D, Guo J. PMID: 29572892.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    31. Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. Hepatology. 2018 06; 67(6):2150-2166. Hartmann P, Hochrath K, Horvath A, Chen P, Seebauer CT, Llorente C, Wang L, Alnouti Y, Fouts DE, Stärkel P, Loomba R, Coulter S, Liddle C, Yu RT, Ling L, Rossi SJ, DePaoli AM, Downes M, Evans RM, Brenner DA, Schnabl B. PMID: 29159825.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    32. Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patients With Nonalcoholic Liver Disease. Clin Gastroenterol Hepatol. 2018 12; 16(12):1974-1982.e7. Caussy C, Chen J, Alquiraish MH, Cepin S, Nguyen P, Hernandez C, Yin M, Bettencourt R, Cachay ER, Jayakumar S, Fortney L, Hooker J, Sy E, Valasek MA, Rizo E, Richards L, Brenner DA, Sirlin CB, Ehman RL, Loomba R. PMID: 29104128.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    33. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. JCI Insight. 2017 12 21; 2(24). Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D, Kisseleva T, Brenner DA, Urrutia R, Lomberk G, Gao Y, Ligresti G, Tschumperlin DJ, Revzin A, Cao S, Shah VH. PMID: 29263300.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    34. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. Int Psychogeriatr. 2018 01; 30(1):31-38. Scelzo A, Di Somma S, Antonini P, Montross LP, Schork N, Brenner D, Jeste DV. PMID: 29229012.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    35. Publisher Correction: Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Nat Commun. 2017 12 12; 8(1):2137. Llorente C, Jepsen P, Inamine T, Wang L, Bluemel S, Wang HJ, Loomba R, Bajaj JS, Schubert ML, Sikaroodi M, Gillevet PM, Xu J, Kisseleva T, Ho SB, DePew J, Du X, Sørensen HT, Vilstrup H, Nelson KE, Brenner DA, Fouts DE, Schnabl B. PMID: 29233961.
      View in: PubMed   Mentions: 1     Fields:    
    36. Human hepatic stellate cell isolation and characterization. J Gastroenterol. 2018 01; 53(1):6-17. Shang L, Hosseini M, Liu X, Kisseleva T, Brenner DA. PMID: 29094206.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    37. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. Hepatol Commun. 2017 12; 1(10):1043-1057. Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R, Quehenberger O, Davidson NO, Dennis EA, Kisseleva T, Brenner DA. PMID: 29404441.
      View in: PubMed   Mentions:
    38. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Nat Commun. 2017 10 16; 8(1):837. Llorente C, Jepsen P, Inamine T, Wang L, Bluemel S, Wang HJ, Loomba R, Bajaj JS, Schubert ML, Sikaroodi M, Gillevet PM, Xu J, Kisseleva T, Ho SB, DePew J, Du X, Sørensen HT, Vilstrup H, Nelson KE, Brenner DA, Fouts DE, Schnabl B. PMID: 29038503.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    39. The fecal microbiome of ALS patients. Neurobiol Aging. 2018 01; 61:132-137. Brenner D, Hiergeist A, Adis C, Mayer B, Gessner A, Ludolph AC, Weishaupt JH. PMID: 29065369.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    40. Thomas E. Starzl: Transplantation pioneer. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):10808-10809. Brenner DA. PMID: 28893997.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    41. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. J Clin Invest. 2017 Jun 30; 127(7):2697-2704. Caussy C, Soni M, Cui J, Bettencourt R, Schork N, Chen CH, Ikhwan MA, Bassirian S, Cepin S, Gonzalez MP, Mendler M, Kono Y, Vodkin I, Mekeel K, Haldorson J, Hemming A, Andrews B, Salotti J, Richards L, Brenner DA, Sirlin CB, Loomba R. PMID: 28628033.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    42. Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. Int J Mol Med. 2017 Aug; 40(2):454-464. Cong M, Zhao W, Liu T, Wang P, Fan X, Zhai Q, Bao X, Zhang D, You H, Kisseleva T, Brenner DA, Jia J, Zhuang H. PMID: 28627620.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    43. Radiation exposure from depleted uranium: The radiation bystander effect. Toxicol Appl Pharmacol. 2017 09 15; 331:135-141. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P, Brenner D. PMID: 28602947.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    44. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. Clin Gastroenterol Hepatol. 2017 11; 15(11):1808-1810. Reinders ME, Wardi G, Bettencourt R, Bouland D, Bazick J, Mendler M, Vodkin I, Kalmaz D, Savides T, Brenner D, Sell RE, Loomba R. PMID: 28602970.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    45. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Cell Metab. 2017 May 02; 25(5):1054-1062.e5. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C, Bettencourt R, Highlander SK, Jones MB, Sirlin CB, Schnabl B, Brinkac L, Schork N, Chen CH, Brenner DA, Biggs W, Yooseph S, Venter JC, Nelson KE. PMID: 28467925.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    46. Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing. Mol Ther Nucleic Acids. 2017 Jun 16; 7:314-323. Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V, Kisseleva T, Brenner D, Duffield J, Burkly LC. PMID: 28624207.
      View in: PubMed   Mentions:
    47. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Invest. 2017 Apr 03; 127(4):1254-1270. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K, Benner C, Heinz S, Bera T, Brenner DA, Kisseleva T. PMID: 28287406.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    48. Liver inflammation and fibrosis. J Clin Invest. 2017 01 03; 127(1):55-64. Koyama Y, Brenner DA. PMID: 28045404.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    49. Three distinct cell populations express extracellular matrix proteins and increase in number during skeletal muscle fibrosis. Am J Physiol Cell Physiol. 2017 Feb 01; 312(2):C131-C143. Chapman MA, Mukund K, Subramaniam S, Brenner D, Lieber RL. PMID: 27881411.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    50. Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood. Hepatology. 2017 01; 65(1):78-88. Decaris ML, Li KW, Emson CL, Gatmaitan M, Liu S, Wang Y, Nyangau E, Colangelo M, Angel TE, Beysen C, Cui J, Hernandez C, Lazaro L, Brenner DA, Turner SM, Hellerstein MK, Loomba R. PMID: 27706836.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    51. Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. Gastroenterology. 2017 02; 152(3):598-607.e2. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA, Rizo E, Richards L, Brenner D, Sirlin CB, Loomba R. PMID: 27911262.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    52. Weight Loss Decreases Magnetic Resonance Elastography Estimated Liver Stiffness in Nonalcoholic Fatty Liver Disease. Clin Gastroenterol Hepatol. 2017 03; 15(3):463-464. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K, Richards L, Rizo E, Hernandez C, Kisseleva T, Schnabl B, Brenner D, Sirlin CB, Loomba R. PMID: 27712981.
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    53. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. Differentiation. 2016 Sep; 92(3):84-92. Karin D, Koyama Y, Brenner D, Kisseleva T. PMID: 27591095.
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    54. Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. Age (Dordr). 2016 Aug; 38(4):291-302. Kim IH, Xu J, Liu X, Koyama Y, Ma HY, Diggle K, You YH, Schilling JM, Jeste D, Sharma K, Brenner DA, Kisseleva T. PMID: 27578257.
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    55. Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study. Hepatology. 2016 11; 64(5):1547-1558. Cui J, Chen CH, Lo MT, Schork N, Bettencourt R, Gonzalez MP, Bhatt A, Hooker J, Shaffer K, Nelson KE, Long MT, Brenner DA, Sirlin CB, Loomba R. PMID: 27315352.
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    56. New Developments on the Treatment of Liver Fibrosis. Dig Dis. 2016; 34(5):589-96. Koyama Y, Xu J, Liu X, Brenner DA. PMID: 27332862.
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    57. Magnetic resonance elastography identifies fibrosis in adults with alpha-1 antitrypsin deficiency liver disease: a prospective study. Aliment Pharmacol Ther. 2016 08; 44(3):287-99. Kim RG, Nguyen P, Bettencourt R, Dulai PS, Haufe W, Hooker J, Minocha J, Valasek MA, Aryafar H, Brenner DA, Sirlin CB, Loomba R. PMID: 27279429.
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    58. Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial. J Hepatol. 2016 08; 65(2):369-76. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R, Richards L, Salotti J, Bhatt A, Hooker J, Haufe W, Hooker C, Brenner DA, Sirlin CB, Loomba R. PMID: 27151177.
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    59. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. Am J Gastroenterol. 2016 07; 111(7):986-94. Loomba R, Cui J, Wolfson T, Haufe W, Hooker J, Szeverenyi N, Ang B, Bhatt A, Wang K, Aryafar H, Behling C, Valasek MA, Lin GY, Gamst A, Brenner DA, Yin M, Glaser KJ, Ehman RL, Sirlin CB. PMID: 27002798.
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    60. NEK1 mutations in familial amyotrophic lateral sclerosis. Brain. 2016 05; 139(Pt 5):e28. Brenner D, Müller K, Wieland T, Weydt P, Böhm S, Lulé D, Hübers A, Neuwirth C, Weber M, Borck G, Wahlqvist M, Danzer KM, Volk AE, Meitinger T, Strom TM, Otto M, Kassubek J, Ludolph AC, Andersen PM, Weishaupt JH. PMID: 26945885.
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    61. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. Ma HY, Xu J, Liu X, Zhu Y, Gao B, Karin M, Tsukamoto H, Jeste DV, Grant I, Roberts AJ, Contet C, Geoffroy C, Zheng B, Brenner D, Kisseleva T. PMID: 27239399.
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    64. Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. Cell Host Microbe. 2016 Feb 10; 19(2):227-39. Wang L, Fouts DE, Stärkel P, Hartmann P, Chen P, Llorente C, DePew J, Moncera K, Ho SB, Brenner DA, Hooper LV, Schnabl B. PMID: 26867181.
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    65. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Front Physiol. 2016; 7:17. Liang S, Kisseleva T, Brenner DA. PMID: 26869935.
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    67. Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion. J Clin Gastroenterol. 2015 Nov-Dec; 49 Suppl 1:S69-73. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS, Brenner DA, Qamar AA, Miloh TA, Guarino A, Guslandi M, Dieleman LA, Ringel Y, Quigley EM, Brandt LJ. PMID: 26447969.
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    69. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Gastroenterology. 2015 Dec; 149(7):1784-93. Loomba R, Schork N, Chen CH, Bettencourt R, Bhatt A, Ang B, Nguyen P, Hernandez C, Richards L, Salotti J, Lin S, Seki E, Nelson KE, Sirlin CB, Brenner D. PMID: 26299412.
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    70. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. PLoS One. 2015; 10(7):e0129743. Lan T, Kisseleva T, Brenner DA. PMID: 26222337.
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    71. New therapies for hepatic fibrosis. Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S75-9. Koyama Y, Brenner DA. PMID: 26206573.
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    72. Novel association between serum pentraxin-2 levels and advanced fibrosis in well-characterised patients with non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2015 Sep; 42(5):582-90. Verna EC, Patel J, Bettencourt R, Nguyen P, Hernandez C, Valasek MA, Kisselva T, Brenner DA, Loomba R. PMID: 26119353.
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    73. Aging and liver disease. Curr Opin Gastroenterol. 2015 May; 31(3):184-91. Kim IH, Kisseleva T, Brenner DA. PMID: 25850346.
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    74. Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. Cell Death Differ. 2015 Nov; 22(11):1837-45. Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF, Brenner D, Harris IS, Chio II, Afzal S, Cairns RA, Cescon DW, Elford AR, Ye J, Lang PA, Li WY, Wakeham A, Duncan GS, Haight J, You-Ten A, Snow B, Yamamoto K, Ohashi PS, Mak TW. PMID: 25882048.
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    76. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. J Exp Med. 2015 Apr 06; 212(4):469-80. Gao L, Brenner D, Llorens-Bobadilla E, Saiz-Castro G, Frank T, Wieghofer P, Hill O, Thiemann M, Karray S, Prinz M, Weishaupt JH, Martin-Villalba A. PMID: 25779632.
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    78. Contribution of bone marrow-derived fibrocytes to liver fibrosis. Hepatobiliary Surg Nutr. 2015 Feb; 4(1):34-47. Xu J, Cong M, Park TJ, Scholten D, Brenner DA, Kisseleva T. PMID: 25713803.
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    84. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. Cell Death Differ. 2015 Jan; 22(1):164-73. Lang PA, Meryk A, Pandyra AA, Brenner D, Brüstle A, Xu HC, Merches K, Lang F, Khairnar V, Sharma P, Funkner P, Recher M, Shaabani N, Duncan GS, Duhan V, Homey B, Ohashi PS, Häussinger D, Knolle PA, Honke N, Mak TW, Lang KS. PMID: 25257173.
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    92. Transcriptional repression of the transforming growth factor ß (TGF-ß) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor ?B (NF-?B) p50 enhances TGF-ß signaling in hepatic stellate cells. J Biol Chem. 2014 Mar 07; 289(10):7082-91. Liu C, Chen X, Yang L, Kisseleva T, Brenner DA, Seki E. PMID: 24448807.
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    94. Fra, Fra away: the complex role of activator protein 1 in liver injury. Hepatology. 2014 Jan; 59(1):19-20. Brenner DA. PMID: 23904356.
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    97. M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. J Cell Biol. 2013 Sep 16; 202(6):951-66. Madsen DH, Leonard D, Masedunskas A, Moyer A, Jürgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS, Brenner DA, Burgdorf S, Engelholm LH, Behrendt N, Holmbeck K, Weigert R, Bugge TH. PMID: 24019537.
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    102. Synergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma. Clin Gastroenterol Hepatol. 2013 Dec; 11(12):1636-45.e1-3. Loomba R, Liu J, Yang HI, Lee MH, Lu SN, Wang LY, Iloeje UH, You SL, Brenner D, Chen CJ. PMID: 23669307.
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    103. Serum ?-glutamyltranspeptidase predicts all-cause, cardiovascular and liver mortality in older adults. J Clin Exp Hepatol. 2013 Mar 01; 3(1):4-11. Loomba R, Doycheva I, Bettencourt R, Cohen B, Wassel CL, Brenner D, Barrett-Connor E. PMID: 23997501.
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    105. Overexpression of endoglin modulates TGF-ß1-signalling pathways in a novel immortalized mouse hepatic stellate cell line. PLoS One. 2013; 8(2):e56116. Meurer SK, Alsamman M, Sahin H, Wasmuth HE, Kisseleva T, Brenner DA, Trautwein C, Weiskirchen R, Scholten D. PMID: 23437087.
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    106. Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2013 Mar; 37(6):630-9. Patel NS, Peterson MR, Brenner DA, Heba E, Sirlin C, Loomba R. PMID: 23383649.
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    107. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Hepatology. 2013 Feb; 57(2):577-89. Miura K, Yang L, van Rooijen N, Brenner DA, Ohnishi H, Seki E. PMID: 22987396.
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    109. Reactive oxygen species delay control of lymphocytic choriomeningitis virus. Cell Death Differ. 2013 Apr; 20(4):649-58. Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA, Harris IS, Shaabani N, Honke N, Maney SK, Lang E, Pozdeev VI, Recher M, Odermatt B, Brenner D, Häussinger D, Ohashi PS, Hengartner H, Zinkernagel RM, Mak TW, Lang KS. PMID: 23328631.
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    118. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Hepatology. 2012 Sep; 56(3):922-32. Le TA, Chen J, Changchien C, Peterson MR, Kono Y, Patton H, Cohen BL, Brenner D, Sirlin C, Loomba R. PMID: 22431131.
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    119. Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis. Gut. 2013 Mar; 62(3):335-6. Schnabl B, Brenner DA. PMID: 22717452.
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    120. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology. 2012 Aug; 143(2):307-20. Seki E, Brenner DA, Karin M. PMID: 22705006.
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    121. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Gastroenterology. 2012 Sep; 143(3):765-776.e3. Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, Österreicher CH, Stickel F, Ley K, Brenner DA, Kisseleva T. PMID: 22687286.
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    122. Origin of myofibroblasts in liver fibrosis. Fibrogenesis Tissue Repair. 2012; 5(Suppl 1):S17. Brenner DA, Kisseleva T, Scholten D, Paik YH, Iwaisako K, Inokuchi S, Schnabl B, Seki E, De Minicis S, Oesterreicher C, Taura K. PMID: 23259769.
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    123. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):9448-53. Kisseleva T, Cong M, Paik Y, Scholten D, Jiang C, Benner C, Iwaisako K, Moore-Morris T, Scott B, Tsukamoto H, Evans SM, Dillmann W, Glass CK, Brenner DA. PMID: 22566629.
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    124. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. Aliment Pharmacol Ther. 2012 Jul; 36(1):22-9. Permutt Z, Le TA, Peterson MR, Seki E, Brenner DA, Sirlin C, Loomba R. PMID: 22554256.
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    125. Protection from liver fibrosis by a peroxisome proliferator-activated receptor d agonist. Proc Natl Acad Sci U S A. 2012 May 22; 109(21):E1369-76. Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y, Sirlin C, Yu E, Yu RT, Downes M, Evans RM, Brenner DA, Schnabl B. PMID: 22538808.
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    126. Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study. PLoS One. 2012; 7(4):e34218. Lee JK, Bettencourt R, Brenner D, Le TA, Barrett-Connor E, Loomba R. PMID: 22514624.
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    127. What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:65-8. Iwaisako K, Brenner DA, Kisseleva T. PMID: 22320919.
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    128. Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease. J Hepatol. 2012 Jun; 56(6):1283-92. Fouts DE, Torralba M, Nelson KE, Brenner DA, Schnabl B. PMID: 22326468.
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    129. Diagnosis and management of patients with a1-antitrypsin (A1AT) deficiency. Clin Gastroenterol Hepatol. 2012 Jun; 10(6):575-80. Nelson DR, Teckman J, Di Bisceglie AM, Brenner DA. PMID: 22200689.
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    130. The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis. J Hepatol. 2012 Apr; 56(4):965-72. Kisseleva T, Brenner DA. PMID: 22173163.
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    131. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. Korean J Hepatol. 2011 Dec; 17(4):251-7. Paik YH, Brenner DA. PMID: 22310788.
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    132. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. Clin Gastroenterol Hepatol. 2012 Mar; 10(3):285-90.e1. Dong MH, Bettencourt R, Brenner DA, Barrett-Connor E, Loomba R. PMID: 22020064.
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    133. Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. Hepatol Res. 2011 Jul; 41(7):683-6. Brenner DA, Seki E, Taura K, Kisseleva T, Deminicis S, Iwaisako K, Inokuchi S, Schnabl B, Oesterreicher CH, Paik YH, Miura K, Kodama Y. PMID: 21711427.
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    134. Migration of fibrocytes in fibrogenic liver injury. Am J Pathol. 2011 Jul; 179(1):189-98. Scholten D, Reichart D, Paik YH, Lindert J, Bhattacharya J, Glass CK, Brenner DA, Kisseleva T. PMID: 21703401.
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    135. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Hepatology. 2011 May; 53(5):1730-41. Paik YH, Iwaisako K, Seki E, Inokuchi S, Schnabl B, Osterreicher CH, Kisseleva T, Brenner DA. PMID: 21384410.
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    136. Is it the end of the line for the EMT? Hepatology. 2011 May; 53(5):1433-5. Kisseleva T, Brenner DA. PMID: 21433040.
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    137. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Liver Int. 2011 Jul; 31(6):762-72. DeLeve LD, Jaeschke H, Kalra VK, Asahina K, Brenner DA, Tsukamoto H. PMID: 21645207.
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    138. Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection. J Mol Med (Berl). 2011 Oct; 89(10):997-1013. Kisseleva T, von Köckritz-Blickwede M, Reichart D, McGillvray SM, Wingender G, Kronenberg M, Glass CK, Nizet V, Brenner DA. PMID: 21499735.
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    139. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol Clin Exp Res. 2011 Aug; 35(8):1509-18. Inokuchi S, Tsukamoto H, Park E, Liu ZX, Brenner DA, Seki E. PMID: 21463341.
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    140. Anti-fibrogenic strategies and the regression of fibrosis. Best Pract Res Clin Gastroenterol. 2011 Apr; 25(2):305-17. Kisseleva T, Brenner DA. PMID: 21497747.
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    141. Alteration of interferon-a/ß receptors in chronic hepatitis B patients. J Clin Immunol. 2011 Jun; 31(3):521-32. Meng F, Wang J, Ge J, Fan X, Wang B, Han L, Kisseleva T, Paik Y, Brenner DA, Wang K. PMID: 21445562.
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    142. Innate immunity in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol. 2011 Apr; 300(4):G516-25. Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, Nagy L, Szabo G, Zakhari S. PMID: 21252049.
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    143. Role of toll-like receptors and their downstream molecules in the development of nonalcoholic Fatty liver disease. Gastroenterol Res Pract. 2010; 2010:362847. Miura K, Seki E, Ohnishi H, Brenner DA. PMID: 21274430.
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    144. What goes up must come down: the emerging role of microRNA in fibrosis. Hepatology. 2011 Jan; 53(1):4-6. Chau BN, Brenner DA. PMID: 21254156.
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    145. Mutation of the 5'-untranslated region stem-loop structure inhibits a1(I) collagen expression in vivo. J Biol Chem. 2011 Mar 11; 286(10):8609-19. Parsons CJ, Stefanovic B, Seki E, Aoyama T, Latour AM, Marzluff WF, Rippe RA, Brenner DA. PMID: 21193410.
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    146. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):308-13. Österreicher CH, Penz-Österreicher M, Grivennikov SI, Guma M, Koltsova EK, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA. PMID: 21173249.
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    147. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. FASEB J. 2011 Apr; 25(4):1133-44. Osawa Y, Seki E, Kodama Y, Suetsugu A, Miura K, Adachi M, Ito H, Shiratori Y, Banno Y, Olefsky JM, Nagaki M, Moriwaki H, Brenner DA, Seishima M. PMID: 21163859.
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    148. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Hepatology. 2011 Jan; 53(1):96-105. Yan AW, Fouts DE, Brandl J, Stärkel P, Torralba M, Schott E, Tsukamoto H, Nelson KE, Brenner DA, Schnabl B. PMID: 21254165.
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    149. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Hepatology. 2010 Oct; 52(4):1420-30. De Minicis S, Seki E, Paik YH, Osterreicher CH, Kodama Y, Kluwe J, Torozzi L, Miyai K, Benedetti A, Schwabe RF, Brenner DA. PMID: 20690191.
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    150. CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. Hepatology. 2010 Oct; 52(4):1390-400. Aoyama T, Inokuchi S, Brenner DA, Seki E. PMID: 20683935.
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    151. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med. 2010 Oct; 16(10):1152-6. Zhang EE, Liu Y, Dentin R, Pongsawakul PY, Liu AC, Hirota T, Nusinow DA, Sun X, Landais S, Kodama Y, Brenner DA, Montminy M, Kay SA. PMID: 20852621.
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    152. Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. Clin Gastroenterol Hepatol. 2010 Oct; 8(10):891-8, 898.e1-2. Loomba R, Yang HI, Su J, Brenner D, Iloeje U, Chen CJ. PMID: 20621202.
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    153. Recent advances in liver stem cell therapy. Curr Opin Gastroenterol. 2010 Jul; 26(4):395-402. Kisseleva T, Gigante E, Brenner DA. PMID: 20495456.
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    154. Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Gastroenterology. 2010 Sep; 139(3):987-98. Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G, Brenner DA, Kisseleva T. PMID: 20546735.
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    155. Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins. Gastroenterology. 2010 Sep; 139(3):836-45, 845.e1. Loomba R, Rao F, Zhang L, Khandrika S, Ziegler MG, Brenner DA, O'Connor DT. PMID: 20537997.
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    156. Awareness, treatment, and control of vascular risk factors among stroke survivors. J Stroke Cerebrovasc Dis. 2010 Jul-Aug; 19(4):311-20. Brenner DA, Zweifler RM, Gomez CR, Kissela BM, Levine D, Howard G, Coull B, Howard VJ. PMID: 20472464.
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    157. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology. 2010 Jul; 139(1):323-34.e7. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H, Olefsky JM, Brenner DA, Seki E. PMID: 20347818.
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    158. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. Hepatology. 2010 Mar; 51(3):942-52. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K, Brenner DA, Ginès P, Bataller R. PMID: 20044807.
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    159. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology. 2010 Mar; 51(3):1027-36. Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M, Brenner DA. PMID: 20052656.
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    160. Hepatic progenitors for liver disease: current position. Stem Cells Cloning. 2010 Feb 25; 3:39-47. Conigliaro A, Brenner DA, Kisseleva T. PMID: 24198509.
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    161. Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. Liver Transpl. 2010 Feb; 16(2):181-90. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA, Brenner DA, Lemasters JJ. PMID: 20104486.
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    162. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):844-9. Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S, Brenner DA, Seki E. PMID: 20080763.
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    163. Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells. Liver Int. 2010 Jan; 30(1):31-41. Sancho-Bru P, Juez E, Moreno M, Khurdayan V, Morales-Ruiz M, Colmenero J, Arroyo V, Brenner DA, Ginès P, Bataller R. PMID: 19929904.
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    164. Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology. 2009 Sep; 50(3):929-38. Osterreicher CH, Taura K, De Minicis S, Seki E, Penz-Osterreicher M, Kodama Y, Kluwe J, Schuster M, Oudit GY, Penninger JM, Brenner DA. PMID: 19650157.
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    165. Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Integr Biol (Camb). 2009 Sep; 1(8-9):513-24. Brafman DA, de Minicis S, Seki E, Shah KD, Teng D, Brenner D, Willert K, Chien S. PMID: 20023766.
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    166. Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Am J Physiol Gastrointest Liver Physiol. 2009 Oct; 297(4):G726-34. Colmenero J, Bataller R, Sancho-Bru P, Domínguez M, Moreno M, Forns X, Bruguera M, Arroyo V, Brenner DA, Ginès P. PMID: 19628656.
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    167. CCR1 and CCR5 promote hepatic fibrosis in mice. J Clin Invest. 2009 Jul; 119(7):1858-70. Seki E, De Minicis S, Gwak GY, Kluwe J, Inokuchi S, Bursill CA, Llovet JM, Brenner DA, Schwabe RF. PMID: 19603542.
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    168. CCR2 promotes hepatic fibrosis in mice. Hepatology. 2009 Jul; 50(1):185-97. Seki E, de Minicis S, Inokuchi S, Taura K, Miyai K, van Rooijen N, Schwabe RF, Brenner DA. PMID: 19441102.
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    169. c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. Gastroenterology. 2009 Oct; 137(4):1467-1477.e5. Kodama Y, Kisseleva T, Iwaisako K, Miura K, Taura K, De Minicis S, Osterreicher CH, Schnabl B, Seki E, Brenner DA. PMID: 19549522.
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    170. Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease. Stroke. 2009 May; 40(5):1721-8. Lavallée PC, Labreuche J, Gongora-Rivera F, Jaramillo A, Brenner D, Klein IF, Touboul PJ, Vicaut E, Amarenco P. PMID: 19286582.
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    171. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Proc Natl Acad Sci U S A. 2009 Mar 03; 106(9):3300-5. Brandl K, Rutschmann S, Li X, Du X, Xiao N, Schnabl B, Brenner DA, Beutler B. PMID: 19202076.
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    172. Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats. Gut. 2009 Nov; 58(11):1517-27. Paik YH, Kim JK, Lee JI, Kang SH, Kim DY, An SH, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Lee KS, Brenner DA. PMID: 19201774.
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    173. The enteropathy of prostaglandin deficiency. J Gastroenterol. 2009; 44 Suppl 19:1-7. Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA, Brenner DA, Milne GL, Morrow JD, Boutaud O, Oates JA. PMID: 19148786.
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    174. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. Gastroenterology. 2009 Apr; 136(4):1423-34. Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y, Brenner DA. PMID: 19249395.
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    175. Molecular pathogenesis of liver fibrosis. Trans Am Clin Climatol Assoc. 2009; 120:361-8. Brenner DA. PMID: 19768189.
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    176. c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps. Hepatology. 2009 Jan; 49(1):6-8. Kodama Y, Brenner DA. PMID: 19111006.
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    177. Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. Hepatology. 2008 Dec; 48(6):2016-26. De Minicis S, Seki E, Oesterreicher C, Schnabl B, Schwabe RF, Brenner DA. PMID: 19025999.
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    178. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol. 2008 Dec; 173(6):1617-27. Lin SL, Kisseleva T, Brenner DA, Duffield JS. PMID: 19008372.
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    179. TNFalpha is required for cholestasis-induced liver fibrosis in the mouse. Biochem Biophys Res Commun. 2009 Jan 16; 378(3):348-53. Gäbele E, Froh M, Arteel GE, Uesugi T, Hellerbrand C, Schölmerich J, Brenner DA, Thurman RG, Rippe RA. PMID: 18996089.
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    180. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Hepatology. 2008 Nov; 48(5):1420-9. Miura K, Taura K, Kodama Y, Schnabl B, Brenner DA. PMID: 18671304.
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    181. NK and NKT cells in liver injury and fibrosis. Clin Immunol. 2009 Jan; 130(1):16-26. Notas G, Kisseleva T, Brenner D. PMID: 18823822.
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    182. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Gastroenterology. 2008 Nov; 135(5):1729-38. Taura K, De Minicis S, Seki E, Hatano E, Iwaisako K, Osterreicher CH, Kodama Y, Miura K, Ikai I, Uemoto S, Brenner DA. PMID: 18823985.
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    183. What is the potential role of antifibrotic agents for the treatment of liver disease? Nat Clin Pract Gastroenterol Hepatol. 2008 Sep; 5(9):496-7. Schnabl B, Scholten D, Brenner DA. PMID: 18628735.
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    184. Toll-like receptors and adaptor molecules in liver disease: update. Hepatology. 2008 Jul; 48(1):322-35. Seki E, Brenner DA. PMID: 18506843.
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    185. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. J Clin Invest. 2008 Jun; 118(6):2121-31. Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA, Brenner DA, Morrow JD, Boutaud O, Oates JA. PMID: 18451993.
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    186. Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. Alcohol. 2008 Aug; 42(5):349-61. Purohit V, Bode JC, Bode C, Brenner DA, Choudhry MA, Hamilton F, Kang YJ, Keshavarzian A, Rao R, Sartor RB, Swanson C, Turner JR. PMID: 18504085.
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    187. The renin-angiotensin-aldosterone system in cerebral small vessel disease. J Neurol. 2008 Jul; 255(7):993-1000. Brenner D, Labreuche J, Pico F, Scheltens P, Poirier O, Cambien F, Amarenco P. PMID: 18446309.
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    188. Fibrogenesis of parenchymal organs. Proc Am Thorac Soc. 2008 Apr 15; 5(3):338-42. Kisseleva T, Brenner DA. PMID: 18403330.
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    189. Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. J Gastroenterol Hepatol. 2008 Mar; 23 Suppl 1:S98-103. De Minicis S, Brenner DA. PMID: 18336675.
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    190. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. Hepatology. 2008 Feb; 47(2):677-85. Adachi M, Brenner DA. PMID: 18220291.
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    191. Mechanisms of fibrogenesis. Exp Biol Med (Maywood). 2008 Feb; 233(2):109-22. Kisseleva T, Brenner DA. PMID: 18222966.
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    192. Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. Hepatology. 2007 Nov; 46(5):1443-52. Mencin A, Seki E, Osawa Y, Kodama Y, De Minicis S, Knowles M, Brenner DA. PMID: 17668872.
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    193. Alzheimer's disease: the vascular connection. Int J Stroke. 2007 Nov; 2(4):243-4. Brenner DA, Alexandrov AV. PMID: 18705924.
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    194. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med. 2007 Nov; 13(11):1324-32. Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, Schwabe RF. PMID: 17952090.
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    195. Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. Gastroenterology. 2007 Dec; 133(6):2019-28. Sancho-Bru P, Bataller R, Fernandez-Varo G, Moreno M, Ramalho LN, Colmenero J, Marí M, Clària J, Jiménez W, Arroyo V, Brenner DA, Ginès P. PMID: 18054572.
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    196. Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB. J Hepatol. 2007 Dec; 47(6):834-43. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y, Brenner DA, Watanabe S. PMID: 17935821.
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    197. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. J Theor Biol. 2007 Dec 07; 249(3):518-31. Sachs RK, Shuryak I, Brenner D, Fakir H, Hlatky L, Hahnfeldt P. PMID: 17897680.
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    198. Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course. J Gastroenterol Hepatol. 2007 Aug; 22(8):1256-64. Tacke F, Trautwein C, Yagmur E, Hellerbrand C, Wiest R, Brenner DA, Schnabl B. PMID: 17688666.
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    199. Nuclear factor-kappaB in the liver: friend or foe? Gastroenterology. 2007 Jun; 132(7):2601-4. Schwabe RF, Brenner DA. PMID: 17570232.
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    200. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. J Gastroenterol Hepatol. 2007 Jun; 22 Suppl 1:S73-8. Kisseleva T, Brenner DA. PMID: 17567473.
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    201. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? J Hepatol. 2007 Aug; 47(2):307-9. Seki E, Brenner DA. PMID: 17566588.
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    202. NOX in liver fibrosis. Arch Biochem Biophys. 2007 Jun 15; 462(2):266-72. De Minicis S, Brenner DA. PMID: 17531188.
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    203. Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force. Gastroenterology. 2007 May; 132(6):2272-5. Kaplan LM, Klein S, Boden G, Brenner DA, Gostout CJ, Lavine JE, Popkin BM, Schirmer BD, Seeley RJ, Yanovski SZ, Cominelli F. PMID: 17498517.
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    204. Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. Dig Dis Sci. 2007 Dec; 52(12):3404-15. Tacke F, Gäbele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C, Brenner DA, Schölmerich J, Schnabl B. PMID: 17415633.
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    205. The genetics of nonalcoholic fatty liver disease. Ann Hepatol. 2007 Apr-Jun; 6(2):83-8. Osterreicher CH, Brenner DA. PMID: 17519829.
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    206. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology. 2007 May; 132(5):1937-46. De Minicis S, Seki E, Uchinami H, Kluwe J, Zhang Y, Brenner DA, Schwabe RF. PMID: 17484886.
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    207. Genomics of liver fibrosis and cirrhosis. Semin Liver Dis. 2007 Feb; 27(1):28-43. Osterreicher CH, Stickel F, Brenner DA. PMID: 17295175.
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    208. The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. Gastroenterology. 2007 Apr; 132(4):1434-46. Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D, Brenner DA. PMID: 17408630.
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    209. Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. Liver Int. 2006 Nov; 26(9):1138-47. Osawa Y, Seki E, Adachi M, Taura K, Kodama Y, Siegmund SV, Schwabe RF, Brenner DA. PMID: 17032415.
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    210. Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation. Cell Death Differ. 2007 Mar; 14(3):568-75. Arnold R, Frey CR, Müller W, Brenner D, Krammer PH, Kiefer F. PMID: 17024227.
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    211. Hepatic stellate cells and the reversal of fibrosis. J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S84-7. Kisseleva T, Brenner DA. PMID: 16958681.
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    212. Immunosuppression, hepatitis B virus variants: Synergistic role in hepatic fibrogenesis. Gastroenterology. 2006 Sep; 131(3):957-60. Paik YH, Brenner DA. PMID: 16952565.
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    213. The Clinical Research Forum and Association of American Physicians disagree with criticism of the NIH Roadmap. J Clin Invest. 2006 Aug; 116(8):2058-9. Crowley W, Courtney J, Jameson L, Pardes H, Moskowitz J, Orringer E, Rubenstein A, Wood A, Rettig R, Ausiello D, Brenner D, Collins F, Elias J, Greene W, Horowitz R, Jameson L, Kieff E, Thompson C, Swain JL. PMID: 16886049.
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    214. Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis. Hepatology. 2006 Aug; 44(2):420-9. Uchinami H, Seki E, Brenner DA, D'Armiento J. PMID: 16871591.
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    215. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. Transplantation. 2006 Jul 27; 82(2):241-50. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H, Brenner DA, Lemasters JJ. PMID: 16858288.
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    216. NADPH oxidase in the liver: defensive, offensive, or fibrogenic? Gastroenterology. 2006 Jul; 131(1):272-5. De Minicis S, Bataller R, Brenner DA. PMID: 16831609.
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    217. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2006 Nov; 291(5):G877-84. Sancho-Bru P, Bataller R, Colmenero J, Gasull X, Moreno M, Arroyo V, Brenner DA, Ginès P. PMID: 16782692.
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    218. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. J Hepatol. 2006 Sep; 45(3):429-38. Kisseleva T, Uchinami H, Feirt N, Quintana-Bustamante O, Segovia JC, Schwabe RF, Brenner DA. PMID: 16846660.
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    219. Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients. Stroke. 2006 Jul; 37(7):1691-6. Brenner D, Labreuche J, Touboul PJ, Schmidt-Petersen K, Poirier O, Perret C, Schönfelder J, Combadière C, Lathrop M, Cambien F, Brand-Herrmann SM, Amarenco P. PMID: 16741188.
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    220. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Gastroenterology. 2006 May; 130(6):1564-72. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N, Seki E, Brenner D, Korenblat K, McCrea J. PMID: 16697719.
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    221. The future of gastroenterology and gastroenterology. Gastroenterology. 2006 May; 130(6):1562. Brenner DA. PMID: 16697718.
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    222. Toll-like receptor signaling in the liver. Gastroenterology. 2006 May; 130(6):1886-900. Schwabe RF, Seki E, Brenner DA. PMID: 16697751.
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    223. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. Lab Invest. 2006 Jul; 86(7):676-86. Paik YH, Lee KS, Lee HJ, Yang KM, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Moon YM, Brenner DA. PMID: 16619004.
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    224. Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation. Am J Physiol Gastrointest Liver Physiol. 2006 Sep; 291(3):G456-63. Lehnert M, Uehara T, Bradford BU, Lind H, Zhong Z, Brenner DA, Marzi I, Lemasters JJ. PMID: 16614372.
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    225. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. Liver Transpl. 2006 Apr; 12(4):550-9. Lehmann TG, Luedde T, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ, Brenner DA. PMID: 16555330.
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    226. Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol. 2006 Apr; 290(4):G583-9. Schwabe RF, Brenner DA. PMID: 16537970.
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    227. Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium. Hepatology. 2006 Apr; 43(4):872-8. Purohit V, Brenner DA. PMID: 16502397.
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    228. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Hepatology. 2005 Dec; 42(6):1320-8. Osawa Y, Hannun YA, Proia RL, Brenner DA. PMID: 16317686.
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    229. Molecular pathogenesis of alcohol-induced hepatic fibrosis. Alcohol Clin Exp Res. 2005 Nov; 29(11 Suppl):102S-109S. Siegmund SV, Brenner DA. PMID: 16344593.
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    230. Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. Biochem Biophys Res Commun. 2005 Sep 16; 335(1):87-96. Schnabl B, Hu K, Mühlbauer M, Hellerbrand C, Stefanovic B, Brenner DA, Schölmerich J. PMID: 16054593.
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    231. Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. Exp Biol Med (Maywood). 2005 Sep; 230(8):573-86. Stefanovic L, Brenner DA, Stefanovic B. PMID: 16118408.
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    232. Liver fibrogenesis: a new role for the renin-angiotensin system. Antioxid Redox Signal. 2005 Sep-Oct; 7(9-10):1346-55. Bataller R, Sancho-Bru P, Ginès P, Brenner DA. PMID: 16115040.
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    233. Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. J Hepatol. 2005 Aug; 43(2):317-23. Yang L, Bataller R, Dulyx J, Coffman TM, Ginès P, Rippe RA, Brenner DA. PMID: 15964094.
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    234. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem. 2005 Jul 29; 280(30):27879-87. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA, Brenner DA. PMID: 15946935.
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    235. NF-kappaB activation in Kupffer cells after partial hepatectomy. Am J Physiol Gastrointest Liver Physiol. 2005 Sep; 289(3):G530-8. Yang L, Magness ST, Bataller R, Rippe RA, Brenner DA. PMID: 15905413.
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    236. Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats. Hepatology. 2005 May; 41(5):1046-55. Bataller R, Gäbele E, Parsons CJ, Morris T, Yang L, Schoonhoven R, Brenner DA, Rippe RA. PMID: 15841463.
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    237. Anandamide induces necrosis in primary hepatic stellate cells. Hepatology. 2005 May; 41(5):1085-95. Siegmund SV, Uchinami H, Osawa Y, Brenner DA, Schwabe RF. PMID: 15841466.
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    238. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. J Biol Chem. 2005 Jun 10; 280(23):21763-72. Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R, Brenner DA, Tabas I. PMID: 15826936.
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    239. JNK mediates hepatic ischemia reperfusion injury. J Hepatol. 2005 Jun; 42(6):850-9. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK, Brenner DA. PMID: 15885356.
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    240. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J Clin Invest. 2005 Apr; 115(4):849-59. Luedde T, Assmus U, Wüstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K, Brenner DA, Manns MP, Pasparakis M, Trautwein C. PMID: 15776110.
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    241. Information assimilation and distribution challenges and goals for real and virtual journals. J Clin Gastroenterol. 2005 Mar; 39(3):181-8. Modlin IM, Adler G, Alexander K, Arnold R, Brenner DA, Corazziari E, Floch MH, LaPorte RE, Peterson WL, Quigley EM, Shapiro MD, Spechler SJ, Spiller RC, Tytgat GN, Wiegers W. PMID: 15718859.
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    242. Liver fibrosis. J Clin Invest. 2005 Feb; 115(2):209-18. Bataller R, Brenner DA. PMID: 15690074.
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    243. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. J Biol Chem. 2005 Apr 08; 280(14):13374-82. Gäbele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW, Brenner DA, Rippe RA. PMID: 15677443.
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    244. Molecular mechanisms of alcohol-induced hepatic fibrosis. Dig Dis. 2005; 23(3-4):264-74. Siegmund SV, Dooley S, Brenner DA. PMID: 16508291.
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    245. Clinical syndromes of alcoholic liver disease. Dig Dis. 2005; 23(3-4):255-63. Adachi M, Brenner DA. PMID: 16508290.
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    246. Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. Gut. 2005 Jan; 54(1):134-41. Sanz S, Pucilowska JB, Liu S, Rodríguez-Ortigosa CM, Lund PK, Brenner DA, Fuller CR, Simmons JG, Pardo A, Martínez-Chantar ML, Fagin JA, Prieto J. PMID: 15591519.
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    247. Data from arrays: an embarrassment of riches. Gastroenterology. 2004 Dec; 127(6):1659. Brenner DA. PMID: 15578500.
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    248. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Hepatology. 2004 Nov; 40(5):1151-9. Magness ST, Bataller R, Yang L, Brenner DA. PMID: 15389867.
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    249. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Hepatology. 2004 Nov; 40(5):1106-15. Parsons CJ, Bradford BU, Pan CQ, Cheung E, Schauer M, Knorr A, Krebs B, Kraft S, Zahn S, Brocks B, Feirt N, Mei B, Cho MS, Ramamoorthi R, Roldan G, Ng P, Lum P, Hirth-Dietrich C, Tomkinson A, Brenner DA. PMID: 15389776.
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    250. From quiescence to activation: Gene regulation in hepatic stellate cells. Gastroenterology. 2004 Oct; 127(4):1260-2. Rippe RA, Brenner DA. PMID: 15481004.
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    251. Akt activation protects rat liver from ischemia/reperfusion injury. J Surg Res. 2004 Oct; 121(2):159-70. Harada N, Hatano E, Koizumi N, Nitta T, Yoshida M, Yamamoto N, Brenner DA, Yamaoka Y. PMID: 15501455.
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    252. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Transplantation. 2004 Aug 15; 78(3):324-32. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R, Brenner DA, Lemasters J. PMID: 15316358.
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    253. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. J Immunol. 2004 Aug 01; 173(3):1561-70. Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE, Brenner DA, Jobin C. PMID: 15265883.
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    254. TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein. Surgery. 2004 Jun; 135(6):619-28. Black D, Bird MA, Hayden M, Schrum LW, Lange P, Samson C, Hatano E, Rippe RA, Brenner DA, Behrns KE. PMID: 15179368.
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    255. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. J Hepatol. 2004 Jun; 40(6):942-51. Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ, Brenner DA, Rippe RA, Behrns KE. PMID: 15158334.
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    256. Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region. J Biol Chem. 2004 May 28; 279(22):23822-9. Lindquist JN, Parsons CJ, Stefanovic B, Brenner DA. PMID: 14973140.
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    257. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. FASEB J. 2004 Apr; 18(6):720-2. Schwabe RF, Uchinami H, Qian T, Bennett BL, Lemasters JJ, Brenner DA. PMID: 14766793.
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    258. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology. 2004 Feb; 126(2):529-40. Bataller R, Paik YH, Lindquist JN, Lemasters JJ, Brenner DA. PMID: 14762790.
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    259. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Mol Cell Biol. 2004 Feb; 24(4):1758-68. Stefanovic B, Stefanovic L, Schnabl B, Bataller R, Brenner DA. PMID: 14749390.
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    260. Gastrointestinal basic science 2002-2003: the year in review. Clin Gastroenterol Hepatol. 2004 Jan; 2(1):9-13. Brenner DA. PMID: 15017626.
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    261. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest. 2003 Nov; 112(9):1383-94. Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ, Brenner DA. PMID: 14597764.
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    262. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. Liver Int. 2003 Oct; 23(5):386-96. Imose M, Nagaki M, Naiki T, Osawa Y, Brenner DA, Asano T, Hayashi H, Kato T, Moriwaki H. PMID: 14708901.
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    263. MELD and the practicing gastroenterologist. Gastroenterology. 2003 Oct; 125(4):1009. Brown RS, Brenner DA. PMID: 14517781.
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    264. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. Transplantation. 2003 Jul 15; 76(1):28-37. Lehmann TG, Wheeler MD, Froh M, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ, Brenner DA, Thurman RG. PMID: 12865782.
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    265. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. J Hepatol. 2003 Jul; 39(1):38-46. Kweon YO, Paik YH, Schnabl B, Qian T, Lemasters JJ, Brenner DA. PMID: 12821042.
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    266. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. Am J Physiol Gastrointest Liver Physiol. 2003 Nov; 285(5):G949-58. Schwabe RF, Bataller R, Brenner DA. PMID: 12829440.
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    267. Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver. Am J Physiol Gastrointest Liver Physiol. 2003 Sep; 285(3):G642-51. Bataller R, Gäbele E, Schoonhoven R, Morris T, Lehnert M, Yang L, Brenner DA, Rippe RA. PMID: 12773299.
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    268. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology. 2003 May; 37(5):1043-55. Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C, Brenner DA. PMID: 12717385.
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    269. Expression of the NF-kappa B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activation. J Immunol. 2003 Apr 15; 170(8):4053-60. Osawa Y, Nagaki M, Banno Y, Brenner DA, Nozawa Y, Moriwaki H, Nakashima S. PMID: 12682234.
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    270. Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition. Toxicol Sci. 2003 May; 73(1):44-52. Oh KW, Qian T, Brenner DA, Lemasters JJ. PMID: 12700412.
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    271. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology. 2003 Apr; 37(4):824-32. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R, Brenner DA. PMID: 12668975.
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    272. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Hepatology. 2003 Apr; 37(4):833-41. Luedde T, Rodriguez ME, Tacke F, Xiong Y, Brenner DA, Trautwein C. PMID: 12668976.
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    273. Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. J Hepatol. 2003 Apr; 38(4):468-75. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T, Brenner DA, Yamaoka Y. PMID: 12663239.
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    274. Hepatitis C and alcohol: fundamental and translational research directions. Alcohol Clin Exp Res. 2003 Apr; 27(4):726-31. Morgan TR, Brenner D, Everhart J, French SW, Fried MW, Gretch DR, Koziel MJ, McClain CJ, Peters MG, Weinman SA, Lucas DL. PMID: 12711937.
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    275. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. Hepatology. 2003 Mar; 37(3):493-503. Bataller R, North KE, Brenner DA. PMID: 12601343.
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    276. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. Hepatology. 2003 Mar; 37(3):653-64. Schnabl B, Purbeck CA, Choi YH, Hagedorn CH, Brenner D. PMID: 12601363.
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    277. Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat. Gastroenterology. 2003 Feb; 124(2):445-58. Iimuro Y, Nishio T, Morimoto T, Nitta T, Stefanovic B, Choi SK, Brenner DA, Yamaoka Y. PMID: 12557150.
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    278. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Hepatology. 2003 Feb; 37(2):267-76. Yata Y, Scanga A, Gillan A, Yang L, Reif S, Breindl M, Brenner DA, Rippe RA. PMID: 12540776.
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    279. Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. Front Biosci. 2003 Jan 01; 8:d69-77. Gäbele E, Brenner DA, Rippe RA. PMID: 12456323.
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    280. The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression. J Biol Chem. 2003 Mar 07; 278(10):8083-90. Reif S, Lang A, Lindquist JN, Yata Y, Gabele E, Scanga A, Brenner DA, Rippe RA. PMID: 12502711.
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    281. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. Hepatology. 2002 Dec; 36(6):1498-508. Kim YS, Schwabe RF, Qian T, Lemasters JJ, Brenner DA. PMID: 12447876.
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    282. 5' stem-loop of collagen alpha 1(I) mRNA inhibits translation in vitro but is required for triple helical collagen synthesis in vivo. J Biol Chem. 2003 Jan 10; 278(2):927-33. Stefanovic B, Brenner DA. PMID: 12419812.
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    283. Tumor necrosis factor alpha-induced interleukin-8 production via NF-kappaB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes. Infect Immun. 2002 Nov; 70(11):6294-301. Osawa Y, Nagaki M, Banno Y, Brenner DA, Asano T, Nozawa Y, Moriwaki H, Nakashima S. PMID: 12379708.
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    284. Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. Antioxid Redox Signal. 2002 Oct; 4(5):769-81. Lemasters JJ, Qian T, He L, Kim JS, Elmore SP, Cascio WE, Brenner DA. PMID: 12470504.
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    285. Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism. Surgery. 2002 Sep; 132(3):441-9. Samson CM, Schrum LW, Bird MA, Lange PA, Brenner DA, Rippe RA, Behrns KE. PMID: 12324757.
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    286. Joint statement on missions and submissions of papers to AGA journals. Gastroenterology. 2002 Sep; 123(3):877-8. Brenner DA, Camilleri M. PMID: 12198713.
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    287. An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. Blood. 2002 Aug 15; 100(4):1470-7. Magness ST, Maeda N, Brenner DA. PMID: 12149233.
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    288. Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. Hepatology. 2002 Aug; 36(2):315-25. Liedtke C, Plümpe J, Kubicka S, Bradham CA, Manns MP, Brenner DA, Trautwein C. PMID: 12143039.
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    289. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2002 Jul; 283(1):G204-11. Schwabe RF, Brenner DA. PMID: 12065308.
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    290. Differential requirement for NF-kappaB-inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas. Am J Physiol Cell Physiol. 2002 Jul; 283(1):C347-57. Russo MP, Bennett BL, Manning AM, Brenner DA, Jobin C. PMID: 12055104.
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    291. Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy. J Biol Chem. 2002 May 17; 277(20):18229-37. Stefanovic B, Schnabl B, Brenner DA. PMID: 11889120.
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    292. Immortal activated human hepatic stellate cells generated by ectopic telomerase expression. Lab Invest. 2002 Mar; 82(3):323-33. Schnabl B, Choi YH, Olsen JC, Hagedorn CH, Brenner DA. PMID: 11896211.
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    293. Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B. J Hepatol. 2001 Dec; 35(6):749-55. Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, Schoonhoven R, Brenner DA, Fried MW, Burkhardt E. PMID: 11738102.
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    294. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. Am J Physiol Gastrointest Liver Physiol. 2001 Dec; 281(6):G1357-68. Hatano E, Brenner DA. PMID: 11705740.
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    295. TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells. Hepatology. 2001 Nov; 34(5):953-63. Schnabl B, Bradham CA, Bennett BL, Manning AM, Stefanovic B, Brenner DA. PMID: 11679966.
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    296. Dominant-negative TAK1 induces c-Myc and G(0) exit in liver. Am J Physiol Gastrointest Liver Physiol. 2001 Nov; 281(5):G1279-89. Bradham CA, Hatano E, Brenner DA. PMID: 11668037.
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    297. Long-term alcohol exposure changes sensitivity of rat Kupffer cells to lipopolysaccharide. Alcohol Clin Exp Res. 2001 Sep; 25(9):1360-7. Enomoto N, Schemmer P, Ikejima K, Takei Y, Sato N, Brenner DA, Thurman RG. PMID: 11584157.
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    298. Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. Circ Res. 2001 Aug 17; 89(4):351-6. Sam F, Sawyer DB, Xie Z, Chang DL, Ngoy S, Brenner DA, Siwik DA, Singh K, Apstein CS, Colucci WS. PMID: 11509452.
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    299. Hepatic stellate cells as a target for the treatment of liver fibrosis. Semin Liver Dis. 2001 Aug; 21(3):437-51. Bataller R, Brenner DA. PMID: 11586471.
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    300. Exercise training attenuates age-associated diastolic dysfunction in rats. Circulation. 2001 Jul 10; 104(2):221-6. Brenner DA, Apstein CS, Saupe KW. PMID: 11447090.
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    301. TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. J Immunol. 2001 Jul 01; 167(1):173-80. Osawa Y, Banno Y, Nagaki M, Brenner DA, Naiki T, Nozawa Y, Nakashima S, Moriwaki H. PMID: 11418646.
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    302. The role of Smad3 in mediating mouse hepatic stellate cell activation. Hepatology. 2001 Jul; 34(1):89-100. Schnabl B, Kweon YO, Frederick JP, Wang XF, Rippe RA, Brenner DA. PMID: 11431738.
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    303. CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. J Immunol. 2001 Jun 01; 166(11):6812-9. Schwabe RF, Schnabl B, Kweon YO, Brenner DA. PMID: 11359840.
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    304. Development of an animal model of chronic alcohol-induced pancreatitis in the rat. Am J Physiol Gastrointest Liver Physiol. 2001 Jun; 280(6):G1178-86. Kono H, Nakagami M, Rusyn I, Connor HD, Stefanovic B, Brenner DA, Mason RP, Arteel GE, Thurman RG. PMID: 11352811.
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    305. Mechanisms of alcoholic liver disease: cytokines. Alcohol Clin Exp Res. 2001 May; 25(5 Suppl ISBRA):251S-253S. Neuman MG, Brenner DA, Rehermann B, Taieb J, Chollet-Martin S, Cohard M, Garaud JJ, Poynard T, Katz GG, Cameron RG, Shear NH, Gao B, Takamatsu M, Yamauchi M, Ohata M, Saito S, Maeyama S, Uchikoshi T, Toda G, Kumagi T, Akbar SM, Abe M, Michitaka K, Horiike N, Onji M. PMID: 11391079.
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    306. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. Circulation. 2001 Apr 10; 103(14):1920-7. Jain M, DerSimonian H, Brenner DA, Ngoy S, Teller P, Edge AS, Zawadzka A, Wetzel K, Sawyer DB, Colucci WS, Apstein CS, Liao R. PMID: 11294813.
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    307. NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis. Gastroenterology. 2001 Apr; 120(5):1251-62. Hatano E, Bennett BL, Manning AM, Qian T, Lemasters JJ, Brenner DA. PMID: 11266388.
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    308. Techniques to measure nucleic acid-protein binding and specificity. Nuclear extract preparations, DNase I footprinting, and mobility shift assays. Methods Mol Biol. 2001; 160:459-79. Rippe RA, Brenner DA, Tugores A. PMID: 11265303.
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    309. Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes. Hepatology. 2001 Jan; 33(1):81-90. Schwabe RF, Bennett BL, Manning AM, Brenner DA. PMID: 11124824.
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    310. Autocrine expression of activated transforming growth factor-beta(1) induces apoptosis in normal rat liver. Am J Physiol Gastrointest Liver Physiol. 2001 Jan; 280(1):G139-48. Schrum LW, Bird MA, Salcher O, Burchardt ER, Grisham JW, Brenner DA, Rippe RA, Behrns KE. PMID: 11123207.
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    311. Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat. Hepatology. 2000 Dec; 32(6):1255-64. Lehmann TG, Wheeler MD, Schwabe RF, Connor HD, Schoonhoven R, Bunzendahl H, Brenner DA, Jude Samulski R, Zhong Z, Thurman RG. PMID: 11093732.
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    312. Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB. Hepatology. 2000 Dec; 32(6):1272-9. Nagaki M, Naiki T, Brenner DA, Osawa Y, Imose M, Hayashi H, Banno Y, Nakashima S, Moriwaki H. PMID: 11093734.
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    313. Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation. Am J Physiol Gastrointest Liver Physiol. 2000 Dec; 279(6):G1333-42. Lang A, Schrum LW, Schoonhoven R, Tuvia S, Solís-Herruzo JA, Tsukamoto H, Brenner DA, Rippe RA. PMID: 11093957.
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    314. Moderate alcohol drinking: effects on the heart and liver. Gastroenterology. 2000 Nov; 119(5):1399-401. Brenner DA. PMID: 11054400.
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    315. Characterization of the interaction between alphaCP(2) and the 3'-untranslated region of collagen alpha1(I) mRNA. Nucleic Acids Res. 2000 Nov 01; 28(21):4306-16. Lindquist JN, Kauschke SG, Stefanovic B, Burchardt ER, Brenner DA. PMID: 11058131.
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    316. The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways. J Biol Chem. 2000 Sep 29; 275(39):30597-604. Xu LH, Yang X, Bradham CA, Brenner DA, Baldwin AS, Craven RJ, Cance WG. PMID: 10899173.
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    317. Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. Gastroenterology. 2000 Aug; 119(2):446-60. Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U, Brenner D, Manns M, Trautwein C. PMID: 10930380.
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    318. Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. J Hepatol. 2000 Jul; 33(1):49-58. Lang A, Schoonhoven R, Tuvia S, Brenner DA, Rippe RA. PMID: 10905586.
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    319. Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver. Am J Physiol Gastrointest Liver Physiol. 2000 Jul; 279(1):G100-6. Enomoto N, Ikejima K, Yamashina S, Enomoto A, Nishiura T, Nishimura T, Brenner DA, Schemmer P, Bradford BU, Rivera CA, Zhong Z, Thurman RG. PMID: 10898751.
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    320. Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells. Blood. 2000 Jun 01; 95(11):3568-77. Magness ST, Tugores A, Brenner DA. PMID: 10828045.
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    321. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes. J Biol Chem. 2000 Apr 21; 275(16):11814-23. Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ, Brenner DA. PMID: 10766806.
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    322. Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells. J Biol Chem. 2000 Apr 21; 275(16):12207-13. Böcker U, Schottelius A, Watson JM, Holt L, Licato LL, Brenner DA, Sartor RB, Jobin C. PMID: 10766857.
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    323. Gene expression and cytokine and enzyme activation in the liver after a burn injury. J Burn Care Rehabil. 2000 Mar-Apr; 21(2):135-41. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T, Brenner DA, Meyer AA. PMID: 10752746.
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    324. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. J Gastroenterol Hepatol. 2000 Mar; 15 Suppl:D20-5. Enomoto N, Ikejima K, Bradford BU, Rivera CA, Kono H, Goto M, Yamashina S, Schemmer P, Kitamura T, Oide H, Takei Y, Hirose M, Shimizu H, Miyazaki A, Brenner DA, Sato N, Thurman RG. PMID: 10759216.
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    325. c-Jun does not mediate hepatocyte apoptosis following NFkappaB inhibition and partial hepatectomy. J Surg Res. 2000 Feb; 88(2):142-9. Schrum LW, Black D, Iimuro Y, Rippe RA, Brenner DA, Behrns KE. PMID: 10644480.
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    326. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. Hepatology. 2000 Feb; 31(2):391-8. Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W, Forman D, Brenner D, Thurman RG. PMID: 10655262.
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    327. The 5' stem-loop regulates expression of collagen alpha1(I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix. Nucleic Acids Res. 2000 Jan 15; 28(2):641-7. Stefanovic B, Lindquist J, Brenner DA. PMID: 10606666.
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    328. Impact of burn injury on hepatic TGF-beta1 expression and plasma TGF-beta1 levels. J Trauma. 2000 Jan; 48(1):39-44. Nishimura T, Nishiura T, deSerres S, Nakagawa T, Brenner DA, Meyer AA. PMID: 10647563.
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    329. Regulation of collagen alpha1(I) expression in hepatic stellate cells. J Gastroenterol. 2000; 35 Suppl 12:80-3. Lindquist JN, Stefanovic B, Brenner DA. PMID: 10779224.
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    330. New aspects of hepatic fibrosis. J Hepatol. 2000; 32(1 Suppl):32-8. Brenner DA, Waterboer T, Choi SK, Lindquist JN, Stefanovic B, Burchardt E, Yamauchi M, Gillan A, Rippe RA. PMID: 10728792.
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    331. Glutamine metabolism stimulates intestinal cell MAPKs by a cAMP-inhibitable, Raf-independent mechanism. Gastroenterology. 2000 Jan; 118(1):90-100. Rhoads JM, Argenzio RA, Chen W, Graves LM, Licato LL, Blikslager AT, Smith J, Gatzy J, Brenner DA. PMID: 10611157.
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    332. Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms. Carcinogenesis. 1999 Nov; 20(11):2095-100. Rusyn I, Bradham CA, Cohn L, Schoonhoven R, Swenberg JA, Brenner DA, Thurman RG. PMID: 10545411.
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    333. Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. J Biol Chem. 1999 Oct 22; 274(43):30919-26. Solís-Herruzo JA, Rippe RA, Schrum LW, de La Torre P, García I, Jeffrey JJ, Muñoz-Yagüe T, Brenner DA. PMID: 10521486.
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    334. NF-kappaB inhibits expression of the alpha1(I) collagen gene. DNA Cell Biol. 1999 Oct; 18(10):751-61. Rippe RA, Schrum LW, Stefanovic B, Solís-Herruzo JA, Brenner DA. PMID: 10541434.
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    335. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. J Immunol. 1999 Sep 15; 163(6):3474-83. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS, Brenner DA, Sartor RB. PMID: 10477620.
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    336. Estriol sensitizes rat Kupffer cells via gut-derived endotoxin. Am J Physiol. 1999 09; 277(3):G671-7. Enomoto N, Yamashina S, Schemmer P, Rivera CA, Bradford BU, Enomoto A, Brenner DA, Thurman RG. PMID: 10484393.
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    337. Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro. J Bone Miner Res. 1999 Aug; 14(8):1272-80. Uzawa K, Grzesik WJ, Nishiura T, Kuznetsov SA, Robey PG, Brenner DA, Yamauchi M. PMID: 10457259.
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    338. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. J Bioenerg Biomembr. 1999 Aug; 31(4):305-19. Lemasters JJ, Qian T, Bradham CA, Brenner DA, Cascio WE, Trost LC, Nishimura Y, Nieminen AL, Herman B. PMID: 10665521.
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    339. IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. Am J Respir Cell Mol Biol. 1999 Aug; 21(2):238-45. Batra RK, Guttridge DC, Brenner DA, Dubinett SM, Baldwin AS, Boucher RC. PMID: 10423407.
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    340. Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells. Liver Transpl Surg. 1999 Jul; 5(4):282-93. Bradham CA, Schemmer P, Stachlewitz RF, Thurman RG, Brenner DA. PMID: 10388501.
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    341. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. Hepatology. 1999 Jun; 29(6):1680-9. Enomoto N, Yamashina S, Kono H, Schemmer P, Rivera CA, Enomoto A, Nishiura T, Nishimura T, Brenner DA, Thurman RG. PMID: 10347108.
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    342. Regulatory role of the conserved stem-loop structure at the 5' end of collagen alpha1(I) mRNA. Mol Cell Biol. 1999 Jun; 19(6):4334-42. Stefanovic B, Hellerbrand C, Brenner DA. PMID: 10330174.
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    343. TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells. J Immunol. 1999 Apr 15; 162(8):4447-54. Jobin C, Holt L, Bradham CA, Streetz K, Brenner DA, Sartor RB. PMID: 10201981.
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    344. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. Am J Physiol. 1999 03; 276(3):G591-8. Ikejima K, Enomoto N, Seabra V, Ikejima A, Brenner DA, Thurman RG. PMID: 10070034.
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    345. Gene regulation in hepatic stellate cell. Ital J Gastroenterol Hepatol. 1999 Mar; 31(2):173-9. Lang A, Brenner DA. PMID: 10363203.
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    346. Molecular and cellular biology of the small intestine. Curr Opin Gastroenterol. 1999 Mar; 15(2):103-7. Jobin C, Behrns KE, Brenner DA. PMID: 17023928.
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    347. Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion. Biochim Biophys Acta. 1999 Jan 06; 1453(1):161-74. Magness ST, Brenner DA. PMID: 9989256.
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    348. The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo. J Hepatol. 1999 Jan; 30(1):77-87. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER, Brenner DA. PMID: 9927153.
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    349. Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice. Gene Expr. 1999; 8(3):151-63. Krempen K, Grotkopp D, Hall K, Bache A, Gillan A, Rippe RA, Brenner DA, Breindl M. PMID: 10634317.
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    350. Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death. Biochem Soc Symp. 1999; 66:205-22. Lemasters JJ, Qian T, Trost LC, Herman B, Cascio WE, Bradham CA, Brenner DA, Nieminen AL. PMID: 10989668.
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    351. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release. Mol Cell Biol. 1998 Nov; 18(11):6353-64. Bradham CA, Qian T, Streetz K, Trautwein C, Brenner DA, Lemasters JJ. PMID: 9774651.
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    352. Porphyrias. J Clin Gastroenterol. 1998 Oct; 27(3):192-8. Scarlett YV, Brenner DA. PMID: 9802444.
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    353. NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis. Am J Physiol. 1998 10; 275(4):C1058-66. Xu Y, Bialik S, Jones BE, Iimuro Y, Kitsis RN, Srinivasan A, Brenner DA, Czaja MJ. PMID: 9755059.
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    354. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. J Gastroenterol Hepatol. 1998 Sep; 13(S1):S39-S50. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, Connor HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT, Brenner D, Kadiiska M, Mason RP. PMID: 28976690.
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    355. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. J Gastroenterol Hepatol. 1998 Sep; 13 Suppl:S39-50. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, Connor HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT, Brenner D, Kadiiska M, Mason RP. PMID: 9792033.
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    356. Signal transduction during liver regeneration. J Gastroenterol Hepatol. 1998 Sep; 13 Suppl:S93-5. Brenner DA. PMID: 9792040.
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    357. Mechanisms of hepatic toxicity. I. TNF-induced liver injury. Am J Physiol. 1998 09; 275(3):G387-92. Bradham CA, Plümpe J, Manns MP, Brenner DA, Trautwein C. PMID: 9724248.
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    358. Signal transduction during liver regeneration. J Gastroenterol Hepatol. 1998 Sep; 13(S1):S93-S95. Brenner DA. PMID: 28976689.
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    359. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta. 1998 Aug 10; 1366(1-2):177-96. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA, Brenner DA, Herman B. PMID: 9714796.
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    360. Cytokines induce NF-kappaB in activated but not in quiescent rat hepatic stellate cells. Am J Physiol. 1998 08; 275(2):G269-78. Hellerbrand C, Jobin C, Licato LL, Sartor RB, Brenner DA. PMID: 9688654.
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    361. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. Gastroenterology. 1998 Aug; 115(2):443-51. Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H, Brenner DA, Thurman RG. PMID: 9679050.
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    362. Analysis of signaling protein kinases in human colon or colorectal carcinomas. Dig Dis Sci. 1998 Jul; 43(7):1454-64. Licato LL, Brenner DA. PMID: 9690379.
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    363. Analysis of the human ferrochelatase promoter in transgenic mice. Blood. 1998 Jul 01; 92(1):320-8. Magness ST, Tugores A, Diala ES, Brenner DA. PMID: 9639532.
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    364. Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation. J Clin Invest. 1998 Jul 01; 102(1):107-14. Bloomer J, Bruzzone C, Zhu L, Scarlett Y, Magness S, Brenner D. PMID: 9649563.
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    365. Mediation by NF-kappa B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors. Gut. 1998 Jun; 42(6):779-87. Jobin C, Hellerbrand C, Licato LL, Brenner DA, Sartor RB. PMID: 9691914.
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    366. Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. Gastroenterology. 1998 May; 114(5):1035-45. Trautwein C, Rakemann T, Brenner DA, Streetz K, Licato L, Manns MP, Tiegs G. PMID: 9558294.
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    367. Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor. Hepatology. 1998 May; 27(5):1285-95. Hellerbrand C, Jobin C, Iimuro Y, Licato L, Sartor RB, Brenner DA. PMID: 9581682.
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    368. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. Am J Physiol. 1998 04; 274(4):G669-76. Ikejima K, Enomoto N, Iimuro Y, Ikejima A, Fang D, Xu J, Forman DT, Brenner DA, Thurman RG. PMID: 9575848.
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    369. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. J Clin Invest. 1998 Feb 15; 101(4):802-11. Iimuro Y, Nishiura T, Hellerbrand C, Behrns KE, Schoonhoven R, Grisham JW, Brenner DA. PMID: 9466975.
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    370. Hepatic porphyrias. Clin Liver Dis. 1998 Feb; 2(1):77-102, vi. Scarlett YV, Brenner DA, Bloomer JR. PMID: 15560047.
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    371. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells. J Immunol. 1998 Jan 01; 160(1):410-8. Jobin C, Panja A, Hellerbrand C, Iimuro Y, Didonato J, Brenner DA, Sartor RB. PMID: 9551998.
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    372. Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy. Biofactors. 1998; 8(3-4):283-5. Lemasters JJ, Qian T, Elmore SP, Trost LC, Nishimura Y, Herman B, Bradham CA, Brenner DA, Nieminen AL. PMID: 9914830.
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    373. In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia. Gastroenterology. 1997 Nov; 113(5):1589-98. Licato LL, Keku TO, Wurzelmann JI, Murray SC, Woosley JT, Sandler RS, Brenner DA. PMID: 9352861.
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    374. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. Am J Physiol. 1997 10; 273(4):G795-803. Xu Y, Bradham C, Brenner DA, Czaja MJ. PMID: 9357820.
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    375. Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cells. Mol Cell Biol. 1997 Sep; 17(9):5201-9. Stefanovic B, Hellerbrand C, Holcik M, Briendl M, Aliebhaber S, Brenner DA. PMID: 9271398.
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    376. L-glutamine stimulates intestinal cell proliferation and activates mitogen-activated protein kinases. Am J Physiol. 1997 May; 272(5 Pt 1):G943-53. Rhoads JM, Argenzio RA, Chen W, Rippe RA, Westwick JK, Cox AD, Berschneider HM, Brenner DA. PMID: 9176200.
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    377. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Hepatology. 1997 May; 25(5):1128-35. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG, Brenner DA. PMID: 9141429.
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    378. Binding of upstream stimulatory factor to an E-box in the 3'-flanking region stimulates alpha1(I) collagen gene transcription. J Biol Chem. 1997 Jan 17; 272(3):1753-60. Rippe RA, Umezawa A, Kimball JP, Breindl M, Brenner DA. PMID: 8999857.
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    379. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. J Clin Invest. 1996 Dec 15; 98(12):2771-8. Mallat A, Préaux AM, Serradeil-Le Gal C, Raufaste D, Gallois C, Brenner DA, Bradham C, Maclouf J, Iourgenko V, Fouassier L, Dhumeaux D, Mavier P, Lotersztajn S. PMID: 8981923.
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    380. Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo. Am J Physiol. 1996 Nov; 271(5 Pt 1):G780-90. Westwick JK, Fleckenstein J, Yin M, Yang SQ, Bradham CA, Brenner DA, Diehl AM. PMID: 8944691.
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    381. Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. Hepatology. 1996 Sep; 24(3):670-6. Wang SC, Tsukamoto H, Brenner DA, Rippe RA. PMID: 8781341.
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    382. Detection of alpha-hydroxyethyl free radical adducts in the pancreas after chronic exposure to alcohol in the rat. Mol Pharmacol. 1996 Sep; 50(3):656-61. Iimuro Y, Bradford BU, Gao W, Kadiiska M, Mason RP, Stefanovic B, Brenner DA, Thurman RG. PMID: 8794907.
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    383. New functions for the aryl hydrocarbon receptor. Hepatology. 1996 Feb; 23(2):379-80. Brenner DA. PMID: 8591868.
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    384. Ferrochelatase cDNA delivered by adenoviral vector corrects biochemical defect in protoporphyric cells. Hum Gene Ther. 1995 Oct; 6(10):1285-90. Magness ST, Brenner DA. PMID: 8590732.
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    385. L-glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line. Am J Physiol. 1995 Oct; 269(4 Pt 1):G591-9. Kandil HM, Argenzio RA, Chen W, Berschneider HM, Stiles AD, Westwick JK, Rippe RA, Brenner DA, Rhoads JM. PMID: 7485512.
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    386. Ceramide activates the stress-activated protein kinases. J Biol Chem. 1995 Sep 29; 270(39):22689-92. Westwick JK, Bielawska AE, Dbaibo G, Hannun YA, Brenner DA. PMID: 7559390.
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    387. Insulin-like growth factor-I and epidermal growth factor interact to regulate growth and gene expression in IEC-6 intestinal epithelial cells. Mol Endocrinol. 1995 Sep; 9(9):1157-65. Simmons JG, Hoyt EC, Westwick JK, Brenner DA, Pucilowska JB, Lund PK. PMID: 7491108.
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    388. Sp1 binding activity increases in activated Ito cells. Hepatology. 1995 Jul; 22(1):241-51. Rippe RA, Almounajed G, Brenner DA. PMID: 7601417.
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    389. Current and prospective therapies for hepatic fibrosis. Compr Ther. 1995 Jun; 21(6):303-7. Trotter JF, Brenner DA. PMID: 7664542.
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    390. Activation of Jun kinase is an early event in hepatic regeneration. J Clin Invest. 1995 Feb; 95(2):803-10. Westwick JK, Weitzel C, Leffert HL, Brenner DA. PMID: 7860764.
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    391. Methods for analyzing c-Jun kinase. Methods Enzymol. 1995; 255:342-59. Westwick JK, Brenner DA. PMID: 8524120.
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    392. Post-transcriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells. Nucleic Acids Symp Ser. 1995; (33):212-4. Stefanovic B, Hellerbrand C, Brenner DA. PMID: 8643373.
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    393. A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene. J Biol Chem. 1994 Dec 09; 269(49):30789-97. Tugores A, Magness ST, Brenner DA. PMID: 7983009.
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    394. Fibrogenesis and type I collagen gene regulation. J Lab Clin Med. 1994 Dec; 124(6):755-60. Brenner DA, Rippe RA, Rhodes K, Trotter JF, Breindl M. PMID: 7798786.
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    395. Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. J Biol Chem. 1994 Oct 21; 269(42):26396-401. Westwick JK, Weitzel C, Minden A, Karin M, Brenner DA. PMID: 7929360.
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    396. Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. Am J Physiol. 1994 Oct; 267(4 Pt 1):G552-61. Diehl AM, Yin M, Fleckenstein J, Yang SQ, Lin HZ, Brenner DA, Westwick J, Bagby G, Nelson S. PMID: 7943321.
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    397. A method for in vitro DNase I footprinting analysis on supercoiled templates. Biotechniques. 1994 Sep; 17(3):410-2. Tugores A, Brenner DA. PMID: 7818885.
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    398. DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism. Mol Cell Biol. 1994 Sep; 14(9):5950-60. Rhodes K, Rippe RA, Umezawa A, Nehls M, Brenner DA, Breindl M. PMID: 8065328.
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    399. Deletion of the ferrochelatase gene in a patient with protoporphyria. Hum Mol Genet. 1994 Sep; 3(9):1695-7. Magness ST, Tugores A, Christensen SR, Wagner-Mcpherson C, Evans GA, Naylor EW, Brenner DA. PMID: 7833934.
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    400. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. J Biol Chem. 1994 Jul 29; 269(30):19203-6. Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD, Brenner DA, Der CJ. PMID: 8034681.
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    401. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. Proc Natl Acad Sci U S A. 1994 Jun 21; 91(13):6030-4. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M, Karin M, Brenner DA. PMID: 8016110.
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    402. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. J Clin Invest. 1993 Dec; 92(6):2916-21. Nehls MC, Brenner DA, Gruss HJ, Dierbach H, Mertelsmann R, Herrmann F. PMID: 7504695.
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    403. Identification of c-fos-responsive elements downstream of TAR in the long terminal repeat of human immunodeficiency virus type-1. J Clin Invest. 1993 Sep; 92(3):1336-48. Roebuck KA, Brenner DA, Kagnoff MF. PMID: 8376588.
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    404. Inactivation of plasmid reporter gene expression by one benzo(a)pyrene diol-epoxide DNA adduct in adult rat hepatocytes. Cancer Res. 1993 May 15; 53(10 Suppl):2279-86. Koch KS, Fletcher RG, Grond MP, Inyang AI, Lu XP, Brenner DA, Leffert HL. PMID: 8485714.
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    405. Type I collagen gene regulation and the molecular pathogenesis of cirrhosis. Am J Physiol. 1993 Apr; 264(4 Pt 1):G589-95. Brenner DA, Westwick J, Breindl M. PMID: 8476045.
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    406. Stimulation of the collagen alpha 1 (I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis. Hepatology. 1993 Feb; 17(2):287-92. Brenner DA, Veloz L, Jaenisch R, Alcorn JM. PMID: 8428727.
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    407. Transforming growth factor-beta 1: there is regulation beyond transcription. Hepatology. 1993 Jan; 17(1):164-6. Brenner DA. PMID: 8423038.
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    408. Activation of activating protein 1 during hepatic acute phase response. Am J Physiol. 1993 Jan; 264(1 Pt 1):G95-103. Hattori M, Tugores A, Westwick JK, Veloz L, Leffert HL, Karin M, Brenner DA. PMID: 8430810.
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    409. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Cell. 1992 Sep 04; 70(5):777-89. Lin A, Frost J, Deng T, Smeal T, al-Alawi N, Kikkawa U, Hunter T, Brenner D, Karin M. PMID: 1516134.
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    410. NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene expression. DNA Cell Biol. 1992 Jul-Aug; 11(6):443-52. Nehls MC, Grapilon ML, Brenner DA. PMID: 1524678.
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    411. A molecular defect in human protoporphyria. Am J Hum Genet. 1992 Jun; 50(6):1203-10. Brenner DA, Didier JM, Frasier F, Christensen SR, Evans GA, Dailey HA. PMID: 1376018.
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    412. A logical approach to the patient with jaundice. Contemp Intern Med. 1992 May; 4(5):43-58. Lyche KD, Brenner DA. PMID: 10171614.
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    413. Differential expression of the transfected liver-specific alpha 1-inhibitor III gene in normal hepatocytes and hepatoma cells in culture. Biochem Biophys Res Commun. 1992 Feb 28; 183(1):184-92. Koch KS, Lu XP, Brenner DA, Leffert HL. PMID: 1543489.
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    414. Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation. Am J Clin Nutr. 1991 12; 54(6 Suppl):1141S-1143S. Houglum KP, Brenner DA, Chojkier M. PMID: 1962560.
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    415. Transforming growth factor B and hepatic fibrosis: cause or effect? Hepatology. 1991 Oct; 14(4 Pt 1):740-2. Brenner DA. PMID: 1916680.
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    416. Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter. Mol Cell Biol. 1991 Aug; 11(8):4065-73. Nehls MC, Rippe RA, Veloz L, Brenner DA. PMID: 2072909.
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    417. d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. Modulation of constitutive collagen gene expression by lipid peroxidation. J Clin Invest. 1991 Jun; 87(6):2230-5. Houglum K, Brenner DA, Chojkier M. PMID: 2040703.
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    418. HIV-1 infection and expression in human colonic cells: infection and expression in CD4+ and CD4- cell lines. AIDS. 1991 Mar; 5(3):275-81. Omary MB, Brenner DA, de Grandpre LY, Roebuck KA, Richman DD, Kagnoff MF. PMID: 2059367.
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    419. Cloning of murine ferrochelatase. Proc Natl Acad Sci U S A. 1991 Feb 01; 88(3):849-53. Brenner DA, Frasier F. PMID: 1704134.
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    420. Expression of human immunodeficiency virus-1 in human colonic cells. Immunol Res. 1991; 10(3-4):452-5. Kagnoff MF, Omary MB, de Grandpre LY, Roebuck KA, Richman DD, Brenner DA. PMID: 1955772.
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    421. Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels. Arch Biochem Biophys. 1990 Dec; 283(2):447-57. Stearns NA, Dong JM, Pan JX, Brenner DA, Sahagian GG. PMID: 2275556.
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    422. A simplified method for the preparation of transcriptionally active liver nuclear extracts. DNA Cell Biol. 1990 Dec; 9(10):777-81. Hattori M, Tugores A, Veloz L, Karin M, Brenner DA. PMID: 2264931.
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    423. Mitogens and hepatocyte growth control in vivo and in vitro. In Vitro Cell Dev Biol. 1990 Nov; 26(11):1011-23. Koch KS, Lu XP, Brenner DA, Fey GH, Martinez-Conde A, Leffert HL. PMID: 2276991.
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    424. Transient induction of c-jun during hepatic regeneration. Hepatology. 1990 Jun; 11(6):909-15. Alcorn JA, Feitelberg SP, Brenner DA. PMID: 2114348.
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    425. Expression of collagen genes in the liver. Mol Biol Med. 1990 Apr; 7(2):105-15. Brenner DA, Alcorn JM, Feitelberg SP, Leffert HL, Chojkier M. PMID: 2342427.
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    426. DNA-mediated gene transfer into adult rat hepatocytes in primary culture. Mol Cell Biol. 1990 Feb; 10(2):689-95. Rippe RA, Brenner DA, Leffert HL. PMID: 2105458.
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    427. Therapy for hepatic fibrosis. Semin Liver Dis. 1990 Feb; 10(1):75-83. Brenner DA, Alcorn JM. PMID: 2186490.
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    428. Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia. J Clin Invest. 1990 Jan; 85(1):248-55. Brenner DA, Buck M, Feitelberg SP, Chojkier M. PMID: 2295699.
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    429. Cellular and molecular biology of hepatocyte growth, regeneration and gene expression. Adv Second Messenger Phosphoprotein Res. 1990; 24:352-8. Leffert HL, Koch KS, Lu XP, Brenner DA, Karin M, Skelly HF, Rippe RA, Fey G, Chojkier M. PMID: 2169815.
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    430. Molecular epidemiology and cancer prevention. Cancer Detect Prev. 1990; 14(6):639-45. Perera FP, Jeffrey AM, Brandt-Rauf PW, Brenner D, Mayer JL, Smith SJ, Latriano L, Hemminki K, Santella RM. PMID: 2257562.
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    431. Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. A role for lipid peroxidation? J Biol Chem. 1989 Oct 05; 264(28):16957-62. Chojkier M, Houglum K, Solis-Herruzo J, Brenner DA. PMID: 2777815.
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    432. Analysis of RNA transcripts for HLA class II genes in human small intestinal biopsies. Gut. 1989 Sep; 30(9):1220-4. Volk BA, Brenner DA, Kagnoff MF. PMID: 2478425.
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    433. Comparison of DNA adducts and sister chromatid exchange in lung cancer cases and controls. Cancer Res. 1989 Aug 15; 49(16):4446-51. Perera F, Mayer J, Jaretzki A, Hearne S, Brenner D, Young TL, Fischman HK, Grimes M, Grantham S, Tang MX. PMID: 2743334.
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    434. Analysis of the collagen alpha 1(I) promoter. Nucleic Acids Res. 1989 Aug 11; 17(15):6055-64. Brenner DA, Rippe RA, Veloz L. PMID: 2771638.
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    435. Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes. J Biol Chem. 1989 Jun 05; 264(16):9583-91. Chojkier M, Brenner DA, Leffert HL. PMID: 2542314.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    436. Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene. Mol Cell Biol. 1989 May; 9(5):2224-7. Rippe RA, Lorenzen SI, Brenner DA, Breindl M. PMID: 2747648.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    437. Transforming growth factor-alpha stimulates proto-oncogene c-jun expression and a mitogenic program in primary cultures of adult rat hepatocytes. DNA. 1989 May; 8(4):279-85. Brenner DA, Koch KS, Leffert HL. PMID: 2504570.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    438. Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Nature. 1989 Feb 16; 337(6208):661-3. Brenner DA, O'Hara M, Angel P, Chojkier M, Karin M. PMID: 2537468.
      View in: PubMed   Mentions: 183     Fields:    Translation:HumansCells
    439. Different mechanisms decrease hepatic collagen and albumin production in fasted rats. Hepatology. 1988 Sep-Oct; 8(5):1040-5. Chojkier M, Flaherty M, Peterkofsky B, Majmudar GH, Spanheimer RG, Brenner DA. PMID: 3047035.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    440. Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. J Biol Chem. 1988 Apr 25; 263(12):5841-5. Solis-Herruzo JA, Brenner DA, Chojkier M. PMID: 3258601.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    441. Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers. Cancer Res. 1988 Apr 15; 48(8):2288-91. Perera FP, Hemminki K, Young TL, Brenner D, Kelly G, Santella RM. PMID: 3127049.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCellsPHPublic Health
    442. Therapeutic strategies for hepatic fibrosis. Hepatology. 1988 Jan-Feb; 8(1):176-82. Chojkier M, Brenner DA. PMID: 3276587.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    443. Acetaldehyde increases collagen gene transcription in cultured human fibroblasts. J Biol Chem. 1987 Dec 25; 262(36):17690-5. Brenner DA, Chojkier M. PMID: 3693368.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    444. DNA adducts, protein adducts, and sister chromatid exchange in cigarette smokers and nonsmokers. J Natl Cancer Inst. 1987 Sep; 79(3):449-56. Perera FP, Santella RM, Brenner D, Poirier MC, Munshi AA, Fischman HK, Van Ryzin J. PMID: 3114532.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    445. Double-strand gap repair results in homologous recombination in mouse L cells. Proc Natl Acad Sci U S A. 1986 Mar; 83(6):1762-6. Brenner DA, Smigocki AC, Camerini-Otero RD. PMID: 3006069.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    446. Effect of insertions, deletions, and double-strand breaks on homologous recombination in mouse L cells. Mol Cell Biol. 1985 Apr; 5(4):684-91. Brenner DA, Smigocki AC, Camerini-Otero RD. PMID: 3990689.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    447. The recombination and integration of DNAs introduced into mouse L cells. Cold Spring Harb Symp Quant Biol. 1984; 49:151-60. Brenner DA, Kato S, Anderson RA, Smigocki AC, Camerini-Otero RD. PMID: 6597753.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    448. The enzymatic defect in variegate prophyria. Studies with human cultured skin fibroblasts. N Engl J Med. 1980 Apr 03; 302(14):765-9. Brenner DA, Bloomer JR. PMID: 7354807.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    449. Comparison of human and bovine protoporphyria. Yale J Biol Med. 1979 Sep-Oct; 52(5):449-54. Brenner DA, Bloomer JR. PMID: 392959.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    450. Study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with protoporphyria. J Clin Invest. 1977 Dec; 60(6):1354-61. Bloomer JR, Brenner DA, Mahoney MJ. PMID: 915001.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
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