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David Brenner

Title(s)Vice Chancellor - Health Sciences, School of Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0602
La Jolla CA 92093
Phone858-534-1501
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    Other Positions
    Title(s)Dean - School of Medicine


    Collapse Biography 
    Collapse Education and Training
    UC San DiegoFellowship1988Gastroenterology
    NIH/NIDDK, Bethesda, MDFellowship1986Genetics & Biochemistry
    Yale UniversityIntern & Residency1985Internal Medicine
    Yale UniversityMD1979Medicine
    Yale UniversityBS1975Biology

    Collapse Research 
    Collapse Research Activities and Funding
    Microbiome as Therapeutic Target in Alcoholic Hepatitis
    NIH U01AA021856Jun 1, 2013 - May 31, 2019
    Role: Principal Investigator
    The Role of Inflammation and Stroma in Digestive Cancer
    NIH U54CA126513Sep 30, 2006 - Sep 21, 2011
    Role: Co-Investigator
    Angiotensin II and NADPH Oxidase in Hepatic Fibrosis
    NIH R01DK072237Sep 15, 2005 - Jun 30, 2011
    Role: Principal Investigator
    Hepatic Stellate Cell Activation induced by Hepatitis C Virus
    NIH R01AA015055Sep 30, 2003 - Aug 31, 2009
    Role: Principal Investigator
    Cond. Acceptance Post-Bac. Prog. Scholarship Fund
    NIH S22MD000227Sep 30, 2002 - Sep 29, 2005
    Role: Principal Investigator
    Molecular Pathogenesis of Apoptosis in Liver Cells
    NIH P01DK059340Sep 21, 2001 - May 31, 2006
    Role: Co-Investigator
    ONCOGENIC K-RAS INDUCTION OF GASTRIN GENE TRANSCRIPTION
    NIH R01DK055686Aug 15, 2000 - Jul 31, 2006
    Role: Principal Investigator
    GENE TECHNOLOGY THERAPY AND ALCOHOL-INDUCED FIBROSIS
    NIH R01AA012586Sep 23, 1999 - Jun 30, 2003
    Role: Principal Investigator
    The Southern California Research Center for ALPD and Cirrhosis
    NIH P50AA011999Jan 1, 1999 - Dec 31, 2023
    Role: Co-Investigator
    Molecular and Cellular Pathogenesis in Alcoholism
    NIH P60AA011605Dec 1, 1997 - Nov 30, 2017
    Role: Co-Investigator
    MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM
    NIH P50AA011605Dec 1, 1997 - Nov 30, 2002
    Role: Co-Investigator
    RAT MODEL OF ALCOHOLIC PANCREATITIS
    NIH R03AA011226Apr 1, 1997 - Mar 31, 1999
    Role: Principal Investigator
    General Clinical Research Center
    NIH M01RR000827Jan 27, 1997 - Nov 30, 2010
    Role: Principal Investigator
    Gastroenterology Research Training
    NIH T32DK007737Aug 1, 1996 - Jun 30, 2021
    Role: Principal Investigator
    FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS
    NIH P01CA050528Feb 1, 1996 - Aug 31, 1992
    Role: Co-Investigator
    GENE THERAPY FOR LIVER DISEASES
    NIH R13DK047627Jan 20, 1994 - Oct 31, 1994
    Role: Principal Investigator
    MOLECULAR DEFECTS IN PROTOPORPHYRIA
    NIH R01DK047361May 1, 1993 - May 31, 2004
    Role: Principal Investigator
    Integrated Center for InVivo Microscopy
    NIH P41RR005959Sep 1, 1990 - Jun 30, 2013
    Role: Co-Investigator
    Molecular Mechanisms by which TNFalpha Modulates Fibrosis
    NIH R01GM041804Apr 1, 1989 - Dec 31, 2014
    Role: Principal Investigator
    MOLECULAR DEFECT IN PROTOPORPHYRIA
    NIH R29DK039996Apr 1, 1988 - Mar 31, 1993
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Heterogeneity of hepatic stellate cells in a mouse model of non-alcoholic steatohepatitis (NASH). Hepatology. 2021 Feb 07. Rosenthal SB, Liu X, Ganguly S, Dhar D, Pasillas MP, Ricciardelli E, Li RZ, Troutman TD, Kisseleva T, Glass CK, Brenner DA. PMID: 33550587.
      View in: PubMed   Mentions:    Fields:    
    2. Previous liver regeneration induces fibro-protective mechanisms during thioacetamide-induced chronic liver injury. Int J Biochem Cell Biol. 2021 Feb 01; 105933. Gratte FD, Pasic S, Abu Bakar NDB, Gogoi-Tiwari J, Liu X, Carlessi R, Kisseleva T, Brenner DA, Ramm GA, Olynyk JK, Tirnitz-Parker JEE. PMID: 33540107.
      View in: PubMed   Mentions:    Fields:    
    3. The genetic landscape of axonal neuropathies in the middle-aged and elderly: Focus on MME. Neurology. 2020 12 15; 95(24):e3163-e3179. PMID: 33144514.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Cell Metab. 2020 Nov 03; 32(5):901. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T, Brenner DA, Sirlin CB, Downes M, Evans RM, Loomba R. PMID: 33147487.
      View in: PubMed   Mentions: 1     Fields:    
    5. Molecular and cellular mechanisms of liver fibrosis and its regression. Nat Rev Gastroenterol Hepatol. 2020 Oct 30. Kisseleva T, Brenner D. PMID: 33128017.
      View in: PubMed   Mentions: 3     Fields:    
    6. Traditional Chinese Medicine Fuzheng Huayu Prevents Development of Liver Fibrosis in Mice. Arch Clin Biomed Res. 2020; 4(5):561-580. Jiang C, Iwaisako K, Cong M, Diggle K, Hassanein T, Brenner DA, Kisseleva T. PMID: 33210080.
      View in: PubMed   Mentions:
    7. Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice. Exp Neurol. 2021 Jan; 335:113496. Sieverding K, Ulmer J, Bruno C, Satoh T, Tsao W, Freischmidt A, Akira S, Wong PC, Ludolph AC, Danzer KM, Lobsiger CS, Brenner D, Weishaupt JH. PMID: 33038415.
      View in: PubMed   Mentions:    Fields:    
    8. Study of loneliness and wisdom in 482 middle-aged and oldest-old adults: a comparison between people in Cilento, Italy and San Diego, USA. Aging Ment Health. 2020 Oct 01; 1-11. Jeste DV, Di Somma S, Lee EE, Nguyen TT, Scalcione M, Biaggi A, Daly R, Liu J, Tu X, Ziedonis D, Glorioso D, Antonini P, Brenner D. PMID: 33000647.
      View in: PubMed   Mentions: 1     Fields:    
    9. Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. Brain Commun. 2020; 2(2):fcaa133. Bruno C, Sieverding K, Freischmidt A, Satoh T, Walther P, Mayer B, Ludolph AC, Akira S, Yilmazer-Hanke D, Danzer KM, Lobsiger CS, Brenner D, Weishaupt JH. PMID: 33005894.
      View in: PubMed   Mentions:
    10. Intestinal Virome in Patients With Alcoholic Hepatitis. Hepatology. 2020 Jul 12. Jiang L, Lang S, Duan Y, Zhang X, Gao B, Chopyk J, Schwanemann LK, Ventura-Cots M, Bataller R, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS, Vargas V, Altamirano J, Caballería J, Shawcross DL, Ho SB, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Kisseleva T, Brenner DA, Tu XM, Stärkel P, Pride D, Fouts DE, Schnabl B. PMID: 32654263.
      View in: PubMed   Mentions:    Fields:    
    11. Western Diet Promotes Renal Injury, Inflammation, and Fibrosis in a Murine Model of Alström Syndrome. Nephron. 2020; 144(8):400-412. Kim YC, Ganguly S, Nespoux J, Freeman B, Zhang H, Brenner D, Dhar D, Vallon V. PMID: 32629454.
      View in: PubMed   Mentions:    Fields:    
    12. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Cell Metab. 2020 Nov 03; 32(5):878-888.e6. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T, Brenner DA, Sirlin CB, Downes M, Evans RM, Loomba R. PMID: 32610095.
      View in: PubMed   Mentions: 3     Fields:    
    13. Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2a-dependent mechanism. Mol Metab. 2020 Nov; 41:101039. Riopel M, Moon JS, Bandyopadhyay GK, You S, Lam K, Liu X, Kisseleva T, Brenner D, Lee YS. PMID: 32534258.
      View in: PubMed   Mentions:    Fields:    
    14. Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis. PLoS One. 2020; 15(6):e0234038. PMID: 32492075.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    15. Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). Medicina (Kaunas). 2020 May 05; 56(5). Pizza V, Antonini P, Marino R, D'Arena G, Lucibello SG, Rizzo M, Brenner DA, Jeste DV, Somma SD. PMID: 32380778.
      View in: PubMed   Mentions:    Fields:    
    16. Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. Front Physiol. 2020; 11:370. Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L, Loomba R, Brenner DA, Stärkel P, Schnabl B. PMID: 32390870.
      View in: PubMed   Mentions:
    17. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. PLoS One. 2020; 15(3):e0229445. Zhang M, Haughey M, Wang NY, Blease K, Kapoun AM, Couto S, Belka I, Hoey T, Groza M, Hartke J, Bennett B, Cain J, Gurney A, Benish B, Castiglioni P, Drew C, Lachowicz J, Carayannopoulos L, Nathan SD, Distler J, Brenner DA, Hariharan K, Cho H, Xie W. PMID: 32160239.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    18. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. JCI Insight. 2020 02 13; 5(3). Xu J, Ma HY, Liu X, Rosenthal S, Baglieri J, McCubbin R, Sun M, Koyama Y, Geoffroy CG, Saijo K, Shang L, Nishio T, Maricic I, Kreifeldt M, Kusumanchi P, Roberts A, Zheng B, Kumar V, Zengler K, Pizzo DP, Hosseini M, Contet C, Glass CK, Liangpunsakul S, Tsukamoto H, Gao B, Karin M, Brenner DA, Koob GF, Kisseleva T. PMID: 32051339.
      View in: PubMed   Mentions: 2     Fields:    
    19. Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. Hepatol Commun. 2020 Apr; 4(4):606-626. Liu X, Rosenthal SB, Meshgin N, Baglieri J, Musallam SG, Diggle K, Lam K, Wu R, Pan SQ, Chen Y, Dorko K, Presnell S, Benner C, Hosseini M, Tsukamoto H, Brenner D, Kisseleva T. PMID: 32258954.
      View in: PubMed   Mentions:
    20. Cardiovascular health of nonagenarians in southern Italy: a cross-sectional, home-based pilot study of longevity. J Cardiovasc Med (Hagerstown). 2020 Feb; 21(2):89-98. Daniels LB, Antonini P, Marino R, Rizzo M, Navarin S, Lucibello SG, Maisel AS, Pizza V, Brenner DA, Jeste DV, Di Somma S. PMID: 31789688.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution. Gastroenterology. 2020 05; 158(6):1728-1744.e14. Liu X, Xu J, Rosenthal S, Zhang LJ, McCubbin R, Meshgin N, Shang L, Koyama Y, Ma HY, Sharma S, Heinz S, Glass CK, Benner C, Brenner DA, Kisseleva T. PMID: 31982409.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    22. Mechanisms of liver fibrosis and its role in liver cancer. Exp Biol Med (Maywood). 2020 01; 245(2):96-108. Dhar D, Baglieri J, Kisseleva T, Brenner DA. PMID: 31924111.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    23. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol. 2020 May; 72(5):946-959. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. PMID: 31899206.
      View in: PubMed   Mentions: 5     Fields:    
    24. Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Cell Metab. 2020 01 07; 31(1):189-206.e8. Sun X, Seidman JS, Zhao P, Troutman TD, Spann NJ, Que X, Zhou F, Liao Z, Pasillas M, Yang X, Magida JA, Kisseleva T, Brenner DA, Downes M, Evans RM, Saltiel AR, Tsimikas S, Glass CK, Witztum JL. PMID: 31761566.
      View in: PubMed   Mentions: 8     Fields:    
    25. The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease. Cell Metab. 2019 11 05; 30(5):850-852. Kisseleva T, Brenner DA. PMID: 31693880.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    26. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Cell Metab. 2019 Sep 03; 30(3):607. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C, Bettencourt R, Highlander SK, Jones MB, Sirlin CB, Schnabl B, Brinkac L, Schork N, Chen CH, Brenner DA, Biggs W, Yooseph S, Venter JC, Nelson KE. PMID: 31484056.
      View in: PubMed   Mentions: 7     Fields:    
    27. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Proc Natl Acad Sci U S A. 2019 07 23; 116(30):15184-15193. Wang L, Mazagova M, Pan C, Yang S, Brandl K, Liu J, Reilly SM, Wang Y, Miao Z, Loomba R, Lu N, Guo Q, Liu J, Yu RT, Downes M, Evans RM, Brenner DA, Saltiel AR, Beutler B, Schnabl B. PMID: 31289229.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    28. Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice. J Hepatol. 2019 09; 71(3):573-585. Nishio T, Hu R, Koyama Y, Liang S, Rosenthal SB, Yamamoto G, Karin D, Baglieri J, Ma HY, Xu J, Liu X, Dhar D, Iwaisako K, Taura K, Brenner DA, Kisseleva T. PMID: 31071368.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    29. Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography. Hepatology. 2019 07; 70(1):127-141. Caussy C, Bhargava M, Villesen IF, Gudmann NS, Leeming DJ, Karsdal MA, Faulkner C, Bao D, Liu A, Lo MT, Bettencourt R, Bassirian S, Richards L, Brenner DA, Chen CH, Sirlin CB, Loomba R. PMID: 30859582.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    30. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. Int J Mol Sci. 2019 Apr 07; 20(7). Baglieri J, Brenner DA, Kisseleva T. PMID: 30959975.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    31. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Nat Commun. 2019 03 29; 10(1):1406. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R, Rizo E, Richards L, Xu ZZ, Downes MR, Evans RM, Brenner DA, Sirlin CB, Knight R, Loomba R. PMID: 30926798.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    32. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. J Exp Med. 2019 02 04; 216(2):267-278. Brenner D, Sieverding K, Bruno C, Lüningschrör P, Buck E, Mungwa S, Fischer L, Brockmann SJ, Ulmer J, Bliederhäuser C, Philibert CE, Satoh T, Akira S, Boillée S, Mayer B, Sendtner M, Ludolph AC, Danzer KM, Lobsiger CS, Freischmidt A, Weishaupt JH. PMID: 30635357.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    33. Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease. Gut. 2019 10; 68(10):1884-1892. Caussy C, Ajmera VH, Puri P, Hsu CL, Bassirian S, Mgdsyan M, Singh S, Faulkner C, Valasek MA, Rizo E, Richards L, Brenner DA, Sirlin CB, Sanyal AJ, Loomba R. PMID: 30567742.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    34. Combatting Fibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis. Hepatol Commun. 2019 Feb; 3(2):180-192. Chen L, Brenner DA, Kisseleva T. PMID: 30766956.
      View in: PubMed   Mentions:
    35. Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD. Aliment Pharmacol Ther. 2019 01; 49(2):183-193. Caussy C, Hsu C, Singh S, Bassirian S, Kolar J, Faulkner C, Sinha N, Bettencourt R, Gara N, Valasek MA, Schnabl B, Richards L, Brenner DA, Hofmann AF, Loomba R. PMID: 30506692.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    36. Publisher Correction: The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol. 2018 12; 15(12):785. Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R. PMID: 29785003.
      View in: PubMed   Mentions: 3     Fields:    
    37. Of Mice and Men and Nonalcoholic Steatohepatitis. Hepatology. 2018 12; 68(6):2059-2061. Brenner DA. PMID: 30033687.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    38. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Gastroenterology. 2019 03; 156(4):1156-1172.e6. Liang S, Ma HY, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T, Brenner DA. PMID: 30445007.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    39. Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians. Clin Gastroenterol Hepatol. 2019 01; 17(2):218-230. Allaband C, McDonald D, Vázquez-Baeza Y, Minich JJ, Tripathi A, Brenner DA, Loomba R, Smarr L, Sandborn WJ, Schnabl B, Dorrestein P, Zarrinpar A, Knight R. PMID: 30240894.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    40. The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol. 2018 07; 15(7):397-411. Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R. PMID: 29748586.
      View in: PubMed   Mentions: 80     Fields:    Translation:Humans
    41. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. Hepatology. 2018 09; 68(3):918-932. Caussy C, Hsu C, Lo MT, Liu A, Bettencourt R, Ajmera VH, Bassirian S, Hooker J, Sy E, Richards L, Schork N, Schnabl B, Brenner DA, Sirlin CB, Chen CH, Loomba R. PMID: 29572891.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    42. Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2. Hepatology. 2018 09; 68(3):1070-1086. PMID: 29572892.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    43. Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. Hepatology. 2018 06; 67(6):2150-2166. Hartmann P, Hochrath K, Horvath A, Chen P, Seebauer CT, Llorente C, Wang L, Alnouti Y, Fouts DE, Stärkel P, Loomba R, Coulter S, Liddle C, Yu RT, Ling L, Rossi SJ, DePaoli AM, Downes M, Evans RM, Brenner DA, Schnabl B. PMID: 29159825.
      View in: PubMed   Mentions: 41     Fields:    Translation:Animals
    44. Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patients With Nonalcoholic Liver Disease. Clin Gastroenterol Hepatol. 2018 12; 16(12):1974-1982.e7. Caussy C, Chen J, Alquiraish MH, Cepin S, Nguyen P, Hernandez C, Yin M, Bettencourt R, Cachay ER, Jayakumar S, Fortney L, Hooker J, Sy E, Valasek MA, Rizo E, Richards L, Brenner DA, Sirlin CB, Ehman RL, Loomba R. PMID: 29104128.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    45. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. JCI Insight. 2017 12 21; 2(24). PMID: 29263300.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    46. Publisher Correction: Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Nat Commun. 2017 12 12; 8(1):2137. Llorente C, Jepsen P, Inamine T, Wang L, Bluemel S, Wang HJ, Loomba R, Bajaj JS, Schubert ML, Sikaroodi M, Gillevet PM, Xu J, Kisseleva T, Ho SB, DePew J, Du X, Sørensen HT, Vilstrup H, Nelson KE, Brenner DA, Fouts DE, Schnabl B. PMID: 29233961.
      View in: PubMed   Mentions: 1     Fields:    
    47. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. Int Psychogeriatr. 2018 01; 30(1):31-38. Scelzo A, Di Somma S, Antonini P, Montross LP, Schork N, Brenner D, Jeste DV. PMID: 29229012.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    48. Human hepatic stellate cell isolation and characterization. J Gastroenterol. 2018 01; 53(1):6-17. Shang L, Hosseini M, Liu X, Kisseleva T, Brenner DA. PMID: 29094206.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    49. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. Hepatol Commun. 2017 12; 1(10):1043-1057. Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R, Quehenberger O, Davidson NO, Dennis EA, Kisseleva T, Brenner DA. PMID: 29404441.
      View in: PubMed   Mentions:
    50. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Nat Commun. 2017 10 16; 8(1):837. Llorente C, Jepsen P, Inamine T, Wang L, Bluemel S, Wang HJ, Loomba R, Bajaj JS, Schubert ML, Sikaroodi M, Gillevet PM, Xu J, Kisseleva T, Ho SB, DePew J, Du X, Sørensen HT, Vilstrup H, Nelson KE, Brenner DA, Fouts DE, Schnabl B. PMID: 29038503.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    51. The fecal microbiome of ALS patients. Neurobiol Aging. 2018 01; 61:132-137. Brenner D, Hiergeist A, Adis C, Mayer B, Gessner A, Ludolph AC, Weishaupt JH. PMID: 29065369.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    52. Thomas E. Starzl: Transplantation pioneer. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):10808-10809. Brenner DA. PMID: 28893997.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    53. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. J Clin Invest. 2017 Jun 30; 127(7):2697-2704. PMID: 28628033.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCTClinical Trials
    54. Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. Int J Mol Med. 2017 Aug; 40(2):454-464. Cong M, Zhao W, Liu T, Wang P, Fan X, Zhai Q, Bao X, Zhang D, You H, Kisseleva T, Brenner DA, Jia J, Zhuang H. PMID: 28627620.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    55. Radiation exposure from depleted uranium: The radiation bystander effect. Toxicol Appl Pharmacol. 2017 09 15; 331:135-141. PMID: 28602947.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
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    159. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology. 2010 Jul; 139(1):323-34.e7. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H, Olefsky JM, Brenner DA, Seki E. PMID: 20347818.
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    160. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology. 2010 Mar; 51(3):1027-36. Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M, Brenner DA. PMID: 20052656.
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    161. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. Hepatology. 2010 Mar; 51(3):942-52. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K, Brenner DA, Ginès P, Bataller R. PMID: 20044807.
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    162. Hepatic progenitors for liver disease: current position. Stem Cells Cloning. 2010 Feb 25; 3:39-47. PMID: 24198509.
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    163. Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. Liver Transpl. 2010 Feb; 16(2):181-90. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA, Brenner DA, Lemasters JJ. PMID: 20104486.
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    164. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):844-9. Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S, Brenner DA, Seki E. PMID: 20080763.
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    165. Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells. Liver Int. 2010 Jan; 30(1):31-41. Sancho-Bru P, Juez E, Moreno M, Khurdayan V, Morales-Ruiz M, Colmenero J, Arroyo V, Brenner DA, Ginès P, Bataller R. PMID: 19929904.
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    166. Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology. 2009 Sep; 50(3):929-38. Osterreicher CH, Taura K, De Minicis S, Seki E, Penz-Osterreicher M, Kodama Y, Kluwe J, Schuster M, Oudit GY, Penninger JM, Brenner DA. PMID: 19650157.
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    167. Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Integr Biol (Camb). 2009 Sep; 1(8-9):513-24. Brafman DA, de Minicis S, Seki E, Shah KD, Teng D, Brenner D, Willert K, Chien S. PMID: 20023766.
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    168. Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Am J Physiol Gastrointest Liver Physiol. 2009 Oct; 297(4):G726-34. Colmenero J, Bataller R, Sancho-Bru P, Domínguez M, Moreno M, Forns X, Bruguera M, Arroyo V, Brenner DA, Ginès P. PMID: 19628656.
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    169. CCR2 promotes hepatic fibrosis in mice. Hepatology. 2009 Jul; 50(1):185-97. Seki E, de Minicis S, Inokuchi S, Taura K, Miyai K, van Rooijen N, Schwabe RF, Brenner DA. PMID: 19441102.
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    170. CCR1 and CCR5 promote hepatic fibrosis in mice. J Clin Invest. 2009 Jul; 119(7):1858-70. Seki E, De Minicis S, Gwak GY, Kluwe J, Inokuchi S, Bursill CA, Llovet JM, Brenner DA, Schwabe RF. PMID: 19603542.
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    171. c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. Gastroenterology. 2009 Oct; 137(4):1467-1477.e5. Kodama Y, Kisseleva T, Iwaisako K, Miura K, Taura K, De Minicis S, Osterreicher CH, Schnabl B, Seki E, Brenner DA. PMID: 19549522.
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    172. Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease. Stroke. 2009 May; 40(5):1721-8. Lavallée PC, Labreuche J, Gongora-Rivera F, Jaramillo A, Brenner D, Klein IF, Touboul PJ, Vicaut E, Amarenco P. PMID: 19286582.
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    173. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Proc Natl Acad Sci U S A. 2009 Mar 03; 106(9):3300-5. Brandl K, Rutschmann S, Li X, Du X, Xiao N, Schnabl B, Brenner DA, Beutler B. PMID: 19202076.
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    174. The enteropathy of prostaglandin deficiency. J Gastroenterol. 2009; 44 Suppl 19:1-7. Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA, Brenner DA, Milne GL, Morrow JD, Boutaud O, Oates JA. PMID: 19148786.
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    175. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. Gastroenterology. 2009 Apr; 136(4):1423-34. Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y, Brenner DA. PMID: 19249395.
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    176. Molecular pathogenesis of liver fibrosis. Trans Am Clin Climatol Assoc. 2009; 120:361-8. Brenner DA. PMID: 19768189.
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    177. c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps. Hepatology. 2009 Jan; 49(1):6-8. Kodama Y, Brenner DA. PMID: 19111006.
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    178. Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. Hepatology. 2008 Dec; 48(6):2016-26. De Minicis S, Seki E, Oesterreicher C, Schnabl B, Schwabe RF, Brenner DA. PMID: 19025999.
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    179. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol. 2008 Dec; 173(6):1617-27. Lin SL, Kisseleva T, Brenner DA, Duffield JS. PMID: 19008372.
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    180. TNFalpha is required for cholestasis-induced liver fibrosis in the mouse. Biochem Biophys Res Commun. 2009 Jan 16; 378(3):348-53. Gäbele E, Froh M, Arteel GE, Uesugi T, Hellerbrand C, Schölmerich J, Brenner DA, Thurman RG, Rippe RA. PMID: 18996089.
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    181. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Hepatology. 2008 Nov; 48(5):1420-9. Miura K, Taura K, Kodama Y, Schnabl B, Brenner DA. PMID: 18671304.
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    182. NK and NKT cells in liver injury and fibrosis. Clin Immunol. 2009 Jan; 130(1):16-26. Notas G, Kisseleva T, Brenner D. PMID: 18823822.
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    183. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Gastroenterology. 2008 Nov; 135(5):1729-38. Taura K, De Minicis S, Seki E, Hatano E, Iwaisako K, Osterreicher CH, Kodama Y, Miura K, Ikai I, Uemoto S, Brenner DA. PMID: 18823985.
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    184. What is the potential role of antifibrotic agents for the treatment of liver disease? Nat Clin Pract Gastroenterol Hepatol. 2008 Sep; 5(9):496-7. Schnabl B, Scholten D, Brenner DA. PMID: 18628735.
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    185. Toll-like receptors and adaptor molecules in liver disease: update. Hepatology. 2008 Jul; 48(1):322-35. Seki E, Brenner DA. PMID: 18506843.
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    186. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. J Clin Invest. 2008 Jun; 118(6):2121-31. Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA, Brenner DA, Morrow JD, Boutaud O, Oates JA. PMID: 18451993.
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    187. Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. Alcohol. 2008 Aug; 42(5):349-61. Purohit V, Bode JC, Bode C, Brenner DA, Choudhry MA, Hamilton F, Kang YJ, Keshavarzian A, Rao R, Sartor RB, Swanson C, Turner JR. PMID: 18504085.
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    188. The renin-angiotensin-aldosterone system in cerebral small vessel disease. J Neurol. 2008 Jul; 255(7):993-1000. Brenner D, Labreuche J, Pico F, Scheltens P, Poirier O, Cambien F, Amarenco P. PMID: 18446309.
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    189. Fibrogenesis of parenchymal organs. Proc Am Thorac Soc. 2008 Apr 15; 5(3):338-42. Kisseleva T, Brenner DA. PMID: 18403330.
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    190. Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. J Gastroenterol Hepatol. 2008 Mar; 23 Suppl 1:S98-103. De Minicis S, Brenner DA. PMID: 18336675.
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    191. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. Hepatology. 2008 Feb; 47(2):677-85. Adachi M, Brenner DA. PMID: 18220291.
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    192. Mechanisms of fibrogenesis. Exp Biol Med (Maywood). 2008 Feb; 233(2):109-22. Kisseleva T, Brenner DA. PMID: 18222966.
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    193. Alzheimer's disease: the vascular connection. Int J Stroke. 2007 Nov; 2(4):243-4. Brenner DA, Alexandrov AV. PMID: 18705924.
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    194. Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. Hepatology. 2007 Nov; 46(5):1443-52. Mencin A, Seki E, Osawa Y, Kodama Y, De Minicis S, Knowles M, Brenner DA. PMID: 17668872.
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    195. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med. 2007 Nov; 13(11):1324-32. Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, Schwabe RF. PMID: 17952090.
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    196. Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. Gastroenterology. 2007 Dec; 133(6):2019-28. Sancho-Bru P, Bataller R, Fernandez-Varo G, Moreno M, Ramalho LN, Colmenero J, Marí M, Clària J, Jiménez W, Arroyo V, Brenner DA, Ginès P. PMID: 18054572.
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    197. Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB. J Hepatol. 2007 Dec; 47(6):834-43. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y, Brenner DA, Watanabe S. PMID: 17935821.
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    198. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. J Theor Biol. 2007 Dec 07; 249(3):518-31. Sachs RK, Shuryak I, Brenner D, Fakir H, Hlatky L, Hahnfeldt P. PMID: 17897680.
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    199. Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course. J Gastroenterol Hepatol. 2007 Aug; 22(8):1256-64. Tacke F, Trautwein C, Yagmur E, Hellerbrand C, Wiest R, Brenner DA, Schnabl B. PMID: 17688666.
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    200. Nuclear factor-kappaB in the liver: friend or foe? Gastroenterology. 2007 Jun; 132(7):2601-4. Schwabe RF, Brenner DA. PMID: 17570232.
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    201. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. J Gastroenterol Hepatol. 2007 Jun; 22 Suppl 1:S73-8. Kisseleva T, Brenner DA. PMID: 17567473.
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    202. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? J Hepatol. 2007 Aug; 47(2):307-9. Seki E, Brenner DA. PMID: 17566588.
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    203. NOX in liver fibrosis. Arch Biochem Biophys. 2007 Jun 15; 462(2):266-72. De Minicis S, Brenner DA. PMID: 17531188.
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    204. Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force. Gastroenterology. 2007 May; 132(6):2272-5. Kaplan LM, Klein S, Boden G, Brenner DA, Gostout CJ, Lavine JE, Popkin BM, Schirmer BD, Seeley RJ, Yanovski SZ, Cominelli F. PMID: 17498517.
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    205. Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. Dig Dis Sci. 2007 Dec; 52(12):3404-15. Tacke F, Gäbele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C, Brenner DA, Schölmerich J, Schnabl B. PMID: 17415633.
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    206. The genetics of nonalcoholic fatty liver disease. Ann Hepatol. 2007 Apr-Jun; 6(2):83-8. Osterreicher CH, Brenner DA. PMID: 17519829.
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    207. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology. 2007 May; 132(5):1937-46. De Minicis S, Seki E, Uchinami H, Kluwe J, Zhang Y, Brenner DA, Schwabe RF. PMID: 17484886.
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    208. Genomics of liver fibrosis and cirrhosis. Semin Liver Dis. 2007 Feb; 27(1):28-43. Osterreicher CH, Stickel F, Brenner DA. PMID: 17295175.
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    209. The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. Gastroenterology. 2007 Apr; 132(4):1434-46. Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D, Brenner DA. PMID: 17408630.
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    210. Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. Liver Int. 2006 Nov; 26(9):1138-47. Osawa Y, Seki E, Adachi M, Taura K, Kodama Y, Siegmund SV, Schwabe RF, Brenner DA. PMID: 17032415.
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    211. Hepatic stellate cells and the reversal of fibrosis. J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S84-7. Kisseleva T, Brenner DA. PMID: 16958681.
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    212. Immunosuppression, hepatitis B virus variants: Synergistic role in hepatic fibrogenesis. Gastroenterology. 2006 Sep; 131(3):957-60. Paik YH, Brenner DA. PMID: 16952565.
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    213. The Clinical Research Forum and Association of American Physicians disagree with criticism of the NIH Roadmap. J Clin Invest. 2006 Aug; 116(8):2058-9. Crowley W, Courtney J, Jameson L, Pardes H, Moskowitz J, Orringer E, Rubenstein A, Wood A, Rettig R, Ausiello D, Brenner D, Collins F, Elias J, Greene W, Horowitz R, Jameson L, Kieff E, Thompson C, Swain JL. PMID: 16886049.
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    214. Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis. Hepatology. 2006 Aug; 44(2):420-9. Uchinami H, Seki E, Brenner DA, D'Armiento J. PMID: 16871591.
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    215. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. Transplantation. 2006 Jul 27; 82(2):241-50. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H, Brenner DA, Lemasters JJ. PMID: 16858288.
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    216. NADPH oxidase in the liver: defensive, offensive, or fibrogenic? Gastroenterology. 2006 Jul; 131(1):272-5. De Minicis S, Bataller R, Brenner DA. PMID: 16831609.
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    217. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2006 Nov; 291(5):G877-84. Sancho-Bru P, Bataller R, Colmenero J, Gasull X, Moreno M, Arroyo V, Brenner DA, Ginès P. PMID: 16782692.
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    218. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. J Hepatol. 2006 Sep; 45(3):429-38. Kisseleva T, Uchinami H, Feirt N, Quintana-Bustamante O, Segovia JC, Schwabe RF, Brenner DA. PMID: 16846660.
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    219. Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients. Stroke. 2006 Jul; 37(7):1691-6. Brenner D, Labreuche J, Touboul PJ, Schmidt-Petersen K, Poirier O, Perret C, Schönfelder J, Combadière C, Lathrop M, Cambien F, Brand-Herrmann SM, Amarenco P. PMID: 16741188.
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    220. The future of gastroenterology and gastroenterology. Gastroenterology. 2006 May; 130(6):1562. Brenner DA. PMID: 16697718.
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    221. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Gastroenterology. 2006 May; 130(6):1564-72. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N, Seki E, Brenner D, Korenblat K, McCrea J. PMID: 16697719.
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    222. Toll-like receptor signaling in the liver. Gastroenterology. 2006 May; 130(6):1886-900. Schwabe RF, Seki E, Brenner DA. PMID: 16697751.
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    223. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. Lab Invest. 2006 Jul; 86(7):676-86. Paik YH, Lee KS, Lee HJ, Yang KM, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Moon YM, Brenner DA. PMID: 16619004.
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    224. Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation. Am J Physiol Gastrointest Liver Physiol. 2006 Sep; 291(3):G456-63. Lehnert M, Uehara T, Bradford BU, Lind H, Zhong Z, Brenner DA, Marzi I, Lemasters JJ. PMID: 16614372.
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    225. Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol. 2006 Apr; 290(4):G583-9. Schwabe RF, Brenner DA. PMID: 16537970.
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    226. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. Liver Transpl. 2006 Apr; 12(4):550-9. Lehmann TG, Luedde T, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ, Brenner DA. PMID: 16555330.
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    227. Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium. Hepatology. 2006 Apr; 43(4):872-8. Purohit V, Brenner DA. PMID: 16502397.
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    228. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Hepatology. 2005 Dec; 42(6):1320-8. Osawa Y, Hannun YA, Proia RL, Brenner DA. PMID: 16317686.
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    229. Molecular pathogenesis of alcohol-induced hepatic fibrosis. Alcohol Clin Exp Res. 2005 Nov; 29(11 Suppl):102S-109S. Siegmund SV, Brenner DA. PMID: 16344593.
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    230. Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. Biochem Biophys Res Commun. 2005 Sep 16; 335(1):87-96. Schnabl B, Hu K, Mühlbauer M, Hellerbrand C, Stefanovic B, Brenner DA, Schölmerich J. PMID: 16054593.
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    231. Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. Exp Biol Med (Maywood). 2005 Sep; 230(8):573-86. Stefanovic L, Brenner DA, Stefanovic B. PMID: 16118408.
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    232. Liver fibrogenesis: a new role for the renin-angiotensin system. Antioxid Redox Signal. 2005 Sep-Oct; 7(9-10):1346-55. Bataller R, Sancho-Bru P, Ginès P, Brenner DA. PMID: 16115040.
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    233. Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. J Hepatol. 2005 Aug; 43(2):317-23. Yang L, Bataller R, Dulyx J, Coffman TM, Ginès P, Rippe RA, Brenner DA. PMID: 15964094.
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    234. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem. 2005 Jul 29; 280(30):27879-87. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA, Brenner DA. PMID: 15946935.
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    235. NF-kappaB activation in Kupffer cells after partial hepatectomy. Am J Physiol Gastrointest Liver Physiol. 2005 Sep; 289(3):G530-8. Yang L, Magness ST, Bataller R, Rippe RA, Brenner DA. PMID: 15905413.
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    236. Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats. Hepatology. 2005 May; 41(5):1046-55. Bataller R, Gäbele E, Parsons CJ, Morris T, Yang L, Schoonhoven R, Brenner DA, Rippe RA. PMID: 15841463.
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    237. Anandamide induces necrosis in primary hepatic stellate cells. Hepatology. 2005 May; 41(5):1085-95. Siegmund SV, Uchinami H, Osawa Y, Brenner DA, Schwabe RF. PMID: 15841466.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    238. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. J Biol Chem. 2005 Jun 10; 280(23):21763-72. Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R, Brenner DA, Tabas I. PMID: 15826936.
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    239. JNK mediates hepatic ischemia reperfusion injury. J Hepatol. 2005 Jun; 42(6):850-9. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK, Brenner DA. PMID: 15885356.
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    240. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J Clin Invest. 2005 Apr; 115(4):849-59. Luedde T, Assmus U, Wüstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K, Brenner DA, Manns MP, Pasparakis M, Trautwein C. PMID: 15776110.
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    241. Information assimilation and distribution challenges and goals for real and virtual journals. J Clin Gastroenterol. 2005 Mar; 39(3):181-8. Modlin IM, Adler G, Alexander K, Arnold R, Brenner DA, Corazziari E, Floch MH, LaPorte RE, Peterson WL, Quigley EM, Shapiro MD, Spechler SJ, Spiller RC, Tytgat GN, Wiegers W. PMID: 15718859.
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    242. Liver fibrosis. J Clin Invest. 2005 Feb; 115(2):209-18. Bataller R, Brenner DA. PMID: 15690074.
      View in: PubMed   Mentions: 1338     Fields:    Translation:HumansAnimals
    243. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. J Biol Chem. 2005 Apr 08; 280(14):13374-82. Gäbele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW, Brenner DA, Rippe RA. PMID: 15677443.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    244. Clinical syndromes of alcoholic liver disease. Dig Dis. 2005; 23(3-4):255-63. Adachi M, Brenner DA. PMID: 16508290.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    245. Molecular mechanisms of alcohol-induced hepatic fibrosis. Dig Dis. 2005; 23(3-4):264-74. Siegmund SV, Dooley S, Brenner DA. PMID: 16508291.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    246. Data from arrays: an embarrassment of riches. Gastroenterology. 2004 Dec; 127(6):1659. Brenner DA. PMID: 15578500.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    247. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Hepatology. 2004 Nov; 40(5):1151-9. Magness ST, Bataller R, Yang L, Brenner DA. PMID: 15389867.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    248. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Hepatology. 2004 Nov; 40(5):1106-15. Parsons CJ, Bradford BU, Pan CQ, Cheung E, Schauer M, Knorr A, Krebs B, Kraft S, Zahn S, Brocks B, Feirt N, Mei B, Cho MS, Ramamoorthi R, Roldan G, Ng P, Lum P, Hirth-Dietrich C, Tomkinson A, Brenner DA. PMID: 15389776.
      View in: PubMed   Mentions: 51     Fields:    Translation:Animals
    249. From quiescence to activation: Gene regulation in hepatic stellate cells. Gastroenterology. 2004 Oct; 127(4):1260-2. Rippe RA, Brenner DA. PMID: 15481004.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    250. Akt activation protects rat liver from ischemia/reperfusion injury. J Surg Res. 2004 Oct; 121(2):159-70. Harada N, Hatano E, Koizumi N, Nitta T, Yoshida M, Yamamoto N, Brenner DA, Yamaoka Y. PMID: 15501455.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    251. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Transplantation. 2004 Aug 15; 78(3):324-32. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R, Brenner DA, Lemasters J. PMID: 15316358.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    252. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. J Immunol. 2004 Aug 01; 173(3):1561-70. Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE, Brenner DA, Jobin C. PMID: 15265883.
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    253. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. J Hepatol. 2004 Jun; 40(6):942-51. Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ, Brenner DA, Rippe RA, Behrns KE. PMID: 15158334.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    254. TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein. Surgery. 2004 Jun; 135(6):619-28. Black D, Bird MA, Hayden M, Schrum LW, Lange P, Samson C, Hatano E, Rippe RA, Brenner DA, Behrns KE. PMID: 15179368.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    255. Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region. J Biol Chem. 2004 May 28; 279(22):23822-9. Lindquist JN, Parsons CJ, Stefanovic B, Brenner DA. PMID: 14973140.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    256. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. FASEB J. 2004 Apr; 18(6):720-2. Schwabe RF, Uchinami H, Qian T, Bennett BL, Lemasters JJ, Brenner DA. PMID: 14766793.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    257. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology. 2004 Feb; 126(2):529-40. Bataller R, Paik YH, Lindquist JN, Lemasters JJ, Brenner DA. PMID: 14762790.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    258. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Mol Cell Biol. 2004 Feb; 24(4):1758-68. Stefanovic B, Stefanovic L, Schnabl B, Bataller R, Brenner DA. PMID: 14749390.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    259. Gastrointestinal basic science 2002-2003: the year in review. Clin Gastroenterol Hepatol. 2004 Jan; 2(1):9-13. Brenner DA. PMID: 15017626.
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    260. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest. 2003 Nov; 112(9):1383-94. Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ, Brenner DA. PMID: 14597764.
      View in: PubMed   Mentions: 163     Fields:    Translation:HumansAnimalsCells
    261. MELD and the practicing gastroenterologist. Gastroenterology. 2003 Oct; 125(4):1009. Brown RS, Brenner DA. PMID: 14517781.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    262. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. Liver Int. 2003 Oct; 23(5):386-96. Imose M, Nagaki M, Naiki T, Osawa Y, Brenner DA, Asano T, Hayashi H, Kato T, Moriwaki H. PMID: 14708901.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    263. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. Transplantation. 2003 Jul 15; 76(1):28-37. Lehmann TG, Wheeler MD, Froh M, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ, Brenner DA, Thurman RG. PMID: 12865782.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    264. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. J Hepatol. 2003 Jul; 39(1):38-46. Kweon YO, Paik YH, Schnabl B, Qian T, Lemasters JJ, Brenner DA. PMID: 12821042.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    265. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. Am J Physiol Gastrointest Liver Physiol. 2003 Nov; 285(5):G949-58. Schwabe RF, Bataller R, Brenner DA. PMID: 12829440.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    266. Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver. Am J Physiol Gastrointest Liver Physiol. 2003 Sep; 285(3):G642-51. Bataller R, Gäbele E, Schoonhoven R, Morris T, Lehnert M, Yang L, Brenner DA, Rippe RA. PMID: 12773299.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    267. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology. 2003 May; 37(5):1043-55. Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C, Brenner DA. PMID: 12717385.
      View in: PubMed   Mentions: 212     Fields:    Translation:HumansAnimalsCells
    268. Expression of the NF-kappa B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activation. J Immunol. 2003 Apr 15; 170(8):4053-60. Osawa Y, Nagaki M, Banno Y, Brenner DA, Nozawa Y, Moriwaki H, Nakashima S. PMID: 12682234.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    269. Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition. Toxicol Sci. 2003 May; 73(1):44-52. Oh KW, Qian T, Brenner DA, Lemasters JJ. PMID: 12700412.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    270. Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. J Hepatol. 2003 Apr; 38(4):468-75. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T, Brenner DA, Yamaoka Y. PMID: 12663239.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    271. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology. 2003 Apr; 37(4):824-32. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R, Brenner DA. PMID: 12668975.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    272. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Hepatology. 2003 Apr; 37(4):833-41. Luedde T, Rodriguez ME, Tacke F, Xiong Y, Brenner DA, Trautwein C. PMID: 12668976.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    273. Hepatitis C and alcohol: fundamental and translational research directions. Alcohol Clin Exp Res. 2003 Apr; 27(4):726-31. Morgan TR, Brenner D, Everhart J, French SW, Fried MW, Gretch DR, Koziel MJ, McClain CJ, Peters MG, Weinman SA, Lucas DL. PMID: 12711937.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    274. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. Hepatology. 2003 Mar; 37(3):653-64. Schnabl B, Purbeck CA, Choi YH, Hagedorn CH, Brenner D. PMID: 12601363.
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    275. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. Hepatology. 2003 Mar; 37(3):493-503. Bataller R, North KE, Brenner DA. PMID: 12601343.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimals
    276. Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat. Gastroenterology. 2003 Feb; 124(2):445-58. Iimuro Y, Nishio T, Morimoto T, Nitta T, Stefanovic B, Choi SK, Brenner DA, Yamaoka Y. PMID: 12557150.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    277. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Hepatology. 2003 Feb; 37(2):267-76. Yata Y, Scanga A, Gillan A, Yang L, Reif S, Breindl M, Brenner DA, Rippe RA. PMID: 12540776.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    278. Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. Front Biosci. 2003 Jan 01; 8:d69-77. Gäbele E, Brenner DA, Rippe RA. PMID: 12456323.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    279. The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression. J Biol Chem. 2003 Mar 07; 278(10):8083-90. Reif S, Lang A, Lindquist JN, Yata Y, Gabele E, Scanga A, Brenner DA, Rippe RA. PMID: 12502711.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    280. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. Hepatology. 2002 Dec; 36(6):1498-508. Kim YS, Schwabe RF, Qian T, Lemasters JJ, Brenner DA. PMID: 12447876.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    281. Tumor necrosis factor alpha-induced interleukin-8 production via NF-kappaB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes. Infect Immun. 2002 Nov; 70(11):6294-301. Osawa Y, Nagaki M, Banno Y, Brenner DA, Asano T, Nozawa Y, Moriwaki H, Nakashima S. PMID: 12379708.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    282. Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. Antioxid Redox Signal. 2002 Oct; 4(5):769-81. Lemasters JJ, Qian T, He L, Kim JS, Elmore SP, Cascio WE, Brenner DA. PMID: 12470504.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    283. Joint statement on missions and submissions of papers to AGA journals. Gastroenterology. 2002 Sep; 123(3):877-8. Brenner DA, Camilleri M. PMID: 12198713.
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    284. Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism. Surgery. 2002 Sep; 132(3):441-9. Samson CM, Schrum LW, Bird MA, Lange PA, Brenner DA, Rippe RA, Behrns KE. PMID: 12324757.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    285. An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. Blood. 2002 Aug 15; 100(4):1470-7. Magness ST, Maeda N, Brenner DA. PMID: 12149233.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    286. Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. Hepatology. 2002 Aug; 36(2):315-25. Liedtke C, Plümpe J, Kubicka S, Bradham CA, Manns MP, Brenner DA, Trautwein C. PMID: 12143039.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    287. Differential requirement for NF-kappaB-inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas. . 2002 Jul; 283(1):C347-57. Russo MP, Bennett BL, Manning AM, Brenner DA, Jobin C. PMID: 12055104.
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    288. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2002 Jul; 283(1):G204-11. Schwabe RF, Brenner DA. PMID: 12065308.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    289. Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy. J Biol Chem. 2002 May 17; 277(20):18229-37. Stefanovic B, Schnabl B, Brenner DA. PMID: 11889120.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    290. Immortal activated human hepatic stellate cells generated by ectopic telomerase expression. Lab Invest. 2002 Mar; 82(3):323-33. Schnabl B, Choi YH, Olsen JC, Hagedorn CH, Brenner DA. PMID: 11896211.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    291. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. J Gastroenterol Hepatol. 1998 Sep; 13(S1):S39-S50. PMID: 28976690.
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