David Brenner

Title(s)Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Other Positions
    Title(s)Dean - School of Medicine


    Collapse Biography 
    Collapse Education and Training
    UC San DiegoFellowship1988Gastroenterology
    NIH/NIDDK, Bethesda, MDFellowship1986Genetics & Biochemistry
    Yale UniversityIntern & Residency1985Internal Medicine
    Yale UniversityMD1979Medicine
    Yale UniversityBS1975Biology

    Collapse Research 
    Collapse Research Activities and Funding
    Microbiome as Therapeutic Target in Alcoholic Hepatitis
    NIH U01AA021856Jun 1, 2013 - May 31, 2019
    Role: Principal Investigator
    The Role of Inflammation and Stroma in Digestive Cancer
    NIH U54CA126513Sep 30, 2006 - Sep 21, 2011
    Role: Co-Investigator
    Angiotensin II and NADPH Oxidase in Hepatic Fibrosis
    NIH R01DK072237Sep 15, 2005 - Jun 30, 2011
    Role: Principal Investigator
    Hepatic Stellate Cell Activation induced by Hepatitis C Virus
    NIH R01AA015055Sep 30, 2003 - Aug 31, 2009
    Role: Principal Investigator
    Cond. Acceptance Post-Bac. Prog. Scholarship Fund
    NIH S22MD000227Sep 30, 2002 - Sep 29, 2005
    Role: Principal Investigator
    Molecular Pathogenesis of Apoptosis in Liver Cells
    NIH P01DK059340Sep 21, 2001 - May 31, 2006
    Role: Co-Investigator
    ONCOGENIC K-RAS INDUCTION OF GASTRIN GENE TRANSCRIPTION
    NIH R01DK055686Aug 15, 2000 - Jul 31, 2006
    Role: Principal Investigator
    GENE TECHNOLOGY THERAPY AND ALCOHOL-INDUCED FIBROSIS
    NIH R01AA012586Sep 23, 1999 - Jun 30, 2003
    Role: Principal Investigator
    The Southern California Research Center for ALPD and Cirrhosis
    NIH P50AA011999Jan 1, 1999 - Dec 31, 2023
    Role: Co-Investigator
    Molecular and Cellular Pathogenesis in Alcoholism
    NIH P60AA011605Dec 1, 1997 - Nov 30, 2017
    Role: Co-Investigator
    MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM
    NIH P50AA011605Dec 1, 1997 - Nov 30, 2002
    Role: Co-Investigator
    RAT MODEL OF ALCOHOLIC PANCREATITIS
    NIH R03AA011226Apr 1, 1997 - Mar 31, 1999
    Role: Principal Investigator
    Gastroenterology Research Training
    NIH T32DK007737Aug 1, 1996 - Jun 30, 2026
    Role: Principal Investigator
    GENE THERAPY FOR LIVER DISEASES
    NIH R13DK047627Jan 20, 1994 - Oct 31, 1994
    Role: Principal Investigator
    MOLECULAR DEFECTS IN PROTOPORPHYRIA
    NIH R01DK047361May 1, 1993 - May 31, 2004
    Role: Principal Investigator
    Integrated Center for InVivo Microscopy
    NIH P41RR005959Sep 1, 1990 - Jun 30, 2013
    Role: Co-Investigator
    FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS
    NIH P01CA050528Sep 8, 1989 - Jan 31, 1998
    Role: Co-Investigator
    Molecular Mechanisms by which TNFalpha Modulates Fibrosis
    NIH R01GM041804Apr 1, 1989 - Dec 31, 2014
    Role: Principal Investigator
    MOLECULAR DEFECT IN PROTOPORPHYRIA
    NIH R29DK039996Apr 1, 1988 - Mar 31, 1993
    Role: Principal Investigator
    General Clinical Research Center
    NIH M01RR000827Mar 1, 1974 - Nov 30, 2010
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Isolation of primary human liver cells from normal and nonalcoholic steatohepatitis livers. STAR Protoc. 2023 Jul 04; 4(3):102391. Liu X, Lam K, Zhao H, Sakane S, Kim HY, Eguileor A, Diggle K, Wu S, Gontijo Weber RC, Soroosh P, Hosseini M, Mekeel K, Brenner DA, Kisseleva T. PMID: 37405925; PMCID: PMC10345194.
      View in: PubMed   Mentions:    Fields:    
    2. PSEN1/SLC20A2 double mutation causes early-onset Alzheimer's disease and primary familial brain calcification co-morbidity. Neurogenetics. 2023 07; 24(3):209-213. Hebestreit S, Schwahn J, Sandikci V, Maros ME, Valkadinov I, Yilmaz R, Eckrich L, Loghmani SB, Lesch H, Conrad J, Wenz H, Ebert A, Brenner D, Weishaupt JH. PMID: 37341843; PMCID: PMC10319679.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Candida albicans-specific Th17 cell-mediated response contributes to alcohol-associated liver disease. Cell Host Microbe. 2023 03 08; 31(3):389-404.e7. Zeng S, Rosati E, Saggau C, Messner B, Chu H, Duan Y, Hartmann P, Wang Y, Ma S, Huang WJM, Lee J, Lee SM, Carvalho-Gontijo R, Zhang V, Hoffmann JP, Kolls JK, Raz E, Brenner DA, Kisseleva T, LeibundGut-Landmann S, Bacher P, Stärkel P, Schnabl B. PMID: 36893735; PMCID: PMC10039706.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Publisher Correction: Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Nature. 2023 Mar; 615(7953):E24. Su H, Yang F, Fu R, Trinh B, Sun N, Liu J, Kumar A, Baglieri J, Siruno J, Le M, Li Y, Dozier S, Nair A, Filliol A, Sinchai N, Rosenthal SB, Santini J, Metallo CM, Molina A, Schwabe RF, Lowy AM, Brenner D, Sun B, Karin M. PMID: 36882540; PMCID: PMC10033397.
      View in: PubMed   Mentions: 1     Fields:    
    5. Frequency of C9orf72 and SOD1 mutations in 302 sporadic ALS patients from three German ALS centers. Amyotroph Lateral Scler Frontotemporal Degener. 2023 08; 24(5-6):414-419. Yilmaz R, Grehl T, Eckrich L, Marschalkowski I, Weishaupt K, Valkadinov I, Simic M, Brenner D, Andersen PM, Wolf J, Weishaupt JH. PMID: 36650645.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Human Hepatic Stellate Cells: Isolation and Characterization. Methods Mol Biol. 2023; 2669:221-232. Liu X, Brenner DA, Kisseleva T. PMID: 37247063.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. The Role of Mesothelin in Activation of Portal Fibroblasts in Cholestatic Liver Injury. Biology (Basel). 2022 Oct 28; 11(11). Nishio T, Koyama Y, Fuji H, Ishizuka K, Iwaisako K, Taura K, Hatano E, Brenner DA, Kisseleva T. PMID: 36358290; PMCID: PMC9687690.
      View in: PubMed   Mentions:
    8. Developing a highly-reliable learning health system. Learn Health Syst. 2023 Jul; 7(3):e10351. El-Kareh R, Brenner DA, Longhurst CA. PMID: 37448457; PMCID: PMC10336486.
      View in: PubMed   Mentions:
    9. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Nature. 2022 10; 610(7931):366-372. Su H, Yang F, Fu R, Trinh B, Sun N, Liu J, Kumar A, Baglieri J, Siruno J, Le M, Li Y, Dozier S, Nair A, Filliol A, Sinchai N, Rosenthal SB, Santini J, Metallo CM, Molina A, Schwabe RF, Lowy AM, Brenner D, Sun B, Karin M. PMID: 36198801; PMCID: PMC9588640.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    10. Multiplex short tandem repeat profiling of immortalized hepatic stellate cell line Col-GFP HSC. PLoS One. 2022; 17(9):e0274219. Meurer SK, Brenner DA, Weiskirchen R. PMID: 36067186; PMCID: PMC9447916.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    11. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. Semin Liver Dis. 2022 08; 42(3):233-249. Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M, Mekeel K, Schnabl B, Loomba R, Karin M, Brenner DA, Kisseleva T. PMID: 36001995; PMCID: PMC9662188.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    12. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Cell Metab. 2022 08 02; 34(8):1201-1213.e5. Gao H, Jin Z, Bandyopadhyay G, Wang G, Zhang D, Rocha KCE, Liu X, Zhao H, Kisseleva T, Brenner DA, Karin M, Ying W. PMID: 35921818; PMCID: PMC9365100.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    13. Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission. Nature. 2022 09; 609(7925):101-108. Karthikeyan S, Levy JI, De Hoff P, Humphrey G, Birmingham A, Jepsen K, Farmer S, Tubb HM, Valles T, Tribelhorn CE, Tsai R, Aigner S, Sathe S, Moshiri N, Henson B, Mark AM, Hakim A, Baer NA, Barber T, Belda-Ferre P, Chacón M, Cheung W, Cresini ES, Eisner ER, Lastrella AL, Lawrence ES, Marotz CA, Ngo TT, Ostrander T, Plascencia A, Salido RA, Seaver P, Smoot EW, McDonald D, Neuhard RM, Scioscia AL, Satterlund AM, Simmons EH, Abelman DB, Brenner D, Bruner JC, Buckley A, Ellison M, Gattas J, Gonias SL, Hale M, Hawkins F, Ikeda L, Jhaveri H, Johnson T, Kellen V, Kremer B, Matthews G, McLawhon RW, Ouillet P, Park D, Pradenas A, Reed S, Riggs L, Sanders A, Sollenberger B, Song A, White B, Winbush T, Aceves CM, Anderson C, Gangavarapu K, Hufbauer E, Kurzban E, Lee J, Matteson NL, Parker E, Perkins SA, Ramesh KS, Robles-Sikisaka R, Schwab MA, Spencer E, Wohl S, Nicholson L, McHardy IH, Dimmock DP, Hobbs CA, Bakhtar O, Harding A, Mendoza A, Bolze A, Becker D, Cirulli ET, Isaksson M, Schiabor Barrett KM, Washington NL, Malone JD, Schafer AM, Gurfield N, Stous S, Fielding-Miller R, Garfein RS, Gaines T, Anderson C, Martin NK, Schooley R, Austin B, MacCannell DR, Kingsmore SF, Lee W, Shah S, McDonald E, Yu AT, Zeller M, Fisch KM, Longhurst C, Maysent P, Pride D, Khosla PK, Laurent LC, Yeo GW, Andersen KG, Knight R. PMID: 35798029; PMCID: PMC9433318.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCellsPHPublic Health
    14. MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH. Cell Metab. 2022 07 05; 34(7):978-990.e4. Gao H, Jin Z, Bandyopadhyay G, Cunha E Rocha K, Liu X, Zhao H, Zhang D, Jouihan H, Pourshahian S, Kisseleva T, Brenner DA, Ying W, Olefsky JM. PMID: 35700738; PMCID: PMC9262870.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    15. Quadruple genetic variants in a sporadic ALS patient. Mol Genet Genomic Med. 2022 07; 10(7):e1953. Yilmaz R, Weishaupt K, Valkadinov I, Knehr A, Brenner D, Weishaupt JH. PMID: 35426263; PMCID: PMC9266611.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    16. Wastewater sequencing uncovers early, cryptic SARS-CoV-2 variant transmission. medRxiv. 2022 Apr 04. Karthikeyan S, Levy JI, De Hoff P, Humphrey G, Birmingham A, Jepsen K, Farmer S, Tubb HM, Valles T, Tribelhorn CE, Tsai R, Aigner S, Sathe S, Moshiri N, Henson B, Mark AM, Hakim A, Baer NA, Barber T, Belda-Ferre P, Chacón M, Cheung W, Cresini ES, Eisner ER, Lastrella AL, Lawrence ES, Marotz CA, Ngo TT, Ostrander T, Plascencia A, Salido RA, Seaver P, Smoot EW, McDonald D, Neuhard RM, Scioscia AL, Satterlund AM, Simmons EH, Abelman DB, Brenner D, Bruner JC, Buckley A, Ellison M, Gattas J, Gonias SL, Hale M, Hawkins F, Ikeda L, Jhaveri H, Johnson T, Kellen V, Kremer B, Matthews G, McLawhon RW, Ouillet P, Park D, Pradenas A, Reed S, Riggs L, Sanders A, Sollenberger B, Song A, White B, Winbush T, Aceves CM, Anderson C, Gangavarapu K, Hufbauer E, Kurzban E, Lee J, Matteson NL, Parker E, Perkins SA, Ramesh KS, Robles-Sikisaka R, Schwab MA, Spencer E, Wohl S, Nicholson L, Mchardy IH, Dimmock DP, Hobbs CA, Bakhtar O, Harding A, Mendoza A, Bolze A, Becker D, Cirulli ET, Isaksson M, Barrett KMS, Washington NL, Malone JD, Schafer AM, Gurfield N, Stous S, Fielding-Miller R, Garfein RS, Gaines T, Anderson C, Martin NK, Schooley R, Austin B, MacCannell DR, Kingsmore SF, Lee W, Shah S, McDonald E, Yu AT, Zeller M, Fisch KM, Longhurst C, Maysent P, Pride D, Khosla PK, Laurent LC, Yeo GW, Andersen KG, Knight R. PMID: 35411350; PMCID: PMC8996633.
      View in: PubMed   Mentions:
    17. Introducing PNAS Nexus. PNAS Nexus. 2022 Mar; 1(1):pgac006. Nelson K, Foufoula-Georgiou E, Gelfand M, Brenner D. PMID: 36712797; PMCID: PMC9802291.
      View in: PubMed   Mentions:
    18. The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis. Front Mol Biosci. 2021; 8:790032. Fuji H, Miller G, Nishio T, Koyama Y, Lam K, Zhang V, Loomba R, Brenner D, Kisseleva T. PMID: 34966784; PMCID: PMC8710774.
      View in: PubMed   Mentions: 2  
    19. CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease. Nat Commun. 2021 12 09; 12(1):7172. Duan Y, Chu H, Brandl K, Jiang L, Zeng S, Meshgin N, Papachristoforou E, Argemi J, Mendes BG, Wang Y, Su H, Sun W, Llorente C, Hendrikx T, Liu X, Hosseini M, Kisseleva T, Brenner DA, Bataller R, Ramachandran P, Karin M, Fu W, Schnabl B. PMID: 34887405; PMCID: PMC8660815.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    20. PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells. PLoS One. 2021; 16(12):e0260721. Rady B, Nishio T, Dhar D, Liu X, Erion M, Kisseleva T, Brenner DA, Pocai A. PMID: 34879108; PMCID: PMC8654208.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    21. Heterogeneity of HSCs in a Mouse Model of NASH. Hepatology. 2021 08; 74(2):667-685. Rosenthal SB, Liu X, Ganguly S, Dhar D, Pasillas MP, Ricciardelli E, Li RZ, Troutman TD, Kisseleva T, Glass CK, Brenner DA. PMID: 33550587; PMCID: PMC8346581.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    22. Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis. Proc Natl Acad Sci U S A. 2021 07 20; 118(29). Nishio T, Koyama Y, Liu X, Rosenthal SB, Yamamoto G, Fuji H, Baglieri J, Li N, Brenner LN, Iwaisako K, Taura K, Hagood JS, LaRusso NF, Bera TK, Pastan I, Brenner DA, Kisseleva T. PMID: 34253615; PMCID: PMC8307749.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    23. Mutation of the 5'-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice. Am J Physiol Heart Circ Physiol. 2021 08 01; 321(2):H435-H445. Ramirez-Perez FI, Woodford ML, Morales-Quinones M, Grunewald ZI, Cabral-Amador FJ, Yoshida T, Brenner DA, Manrique-Acevedo C, Martinez-Lemus LA, Chandrasekar B, Padilla J. PMID: 34242094; PMCID: PMC8526337.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    24. Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice. Am J Pathol. 2021 09; 191(9):1564-1579. Baglieri J, Zhang C, Liang S, Liu X, Nishio T, Rosenthal SB, Dhar D, Su H, Cong M, Jia J, Hosseini M, Karin M, Kisseleva T, Brenner DA. PMID: 34119473; PMCID: PMC8406794.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    25. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. Cell Mol Gastroenterol Hepatol. 2021; 12(3):891-920. Ganguly S, Muench GA, Shang L, Rosenthal SB, Rahman G, Wang R, Wang Y, Kwon HC, Diomino AM, Kisseleva T, Soorosh P, Hosseini M, Knight R, Schnabl B, Brenner DA, Dhar D. PMID: 34062281; PMCID: PMC8342972.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    26. Intestinal α1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice. Cell Mol Gastroenterol Hepatol. 2021; 12(1):293-320. Zhou R, Llorente C, Cao J, Zaramela LS, Zeng S, Gao B, Li SZ, Welch RD, Huang FQ, Qi LW, Pan C, Huang Y, Zhou P, Beussen I, Zhang Y, Bryam G, Fiehn O, Wang L, Liu EH, Yu RT, Downes M, Evans RM, Goglin K, Fouts DE, Brenner DA, Bode L, Fan X, Zengler K, Schnabl B. PMID: 33631374; PMCID: PMC8166943.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    27. Previous liver regeneration induces fibro-protective mechanisms during thioacetamide-induced chronic liver injury. Int J Biochem Cell Biol. 2021 05; 134:105933. Gratte FD, Pasic S, Abu Bakar NDB, Gogoi-Tiwari J, Liu X, Carlessi R, Kisseleva T, Brenner DA, Ramm GA, Olynyk JK, Tirnitz-Parker JEE. PMID: 33540107.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    28. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Cell Metab. 2020 Nov 03; 32(5):901. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T, Brenner DA, Sirlin CB, Downes M, Evans RM, Loomba R. PMID: 33147487; PMCID: PMC7891106.
      View in: PubMed   Mentions: 24     Fields:    
    29. The genetic landscape of axonal neuropathies in the middle-aged and elderly: Focus on MME. Neurology. 2020 12 15; 95(24):e3163-e3179. Senderek J, Lassuthova P, Kabzinska D, Abreu L, Baets J, Beetz C, Braathen GJ, Brenner D, Dalton J, Dankwa L, Deconinck T, De Jonghe P, Dräger B, Eggermann K, Ellis M, Fischer C, Stojkovic T, Herrmann DN, Horvath R, Høyer H, Iglseder S, Kennerson M, Kinslechner K, Kohler JN, Kurth I, Laing NG, Lamont PJ, Wolfgang N L, Ludolph A, Marques W, Nicholson G, Ong R, Petri S, Ravenscroft G, Rebelo A, Ricci G, Rudnik-Schöneborn S, Schirmacher A, Schlotter-Weigel B, Schoels L, Schüle R, Synofzik M, Francou B, Strom TM, Wagner J, Walk D, Wanschitz J, Weinmann D, Weishaupt J, Wiessner M, Windhager R, Young P, Züchner S, Toegel S, Seeman P, Kochanski A, Auer-Grumbach M. PMID: 33144514; PMCID: PMC7836667.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    30. Molecular and cellular mechanisms of liver fibrosis and its regression. Nat Rev Gastroenterol Hepatol. 2021 03; 18(3):151-166. Kisseleva T, Brenner D. PMID: 33128017.
      View in: PubMed   Mentions: 284     Fields:    Translation:HumansCells
    31. Traditional Chinese Medicine Fuzheng Huayu Prevents Development of Liver Fibrosis in Mice. Arch Clin Biomed Res. 2020; 4(5):561-580. Jiang C, Iwaisako K, Cong M, Diggle K, Hassanein T, Brenner DA, Kisseleva T. PMID: 33210080; PMCID: PMC7671588.
      View in: PubMed   Mentions: 5  
    32. Intestinal Virome in Patients With Alcoholic Hepatitis. Hepatology. 2020 12; 72(6):2182-2196. Jiang L, Lang S, Duan Y, Zhang X, Gao B, Chopyk J, Schwanemann LK, Ventura-Cots M, Bataller R, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS, Vargas V, Altamirano J, Caballería J, Shawcross DL, Ho SB, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Kisseleva T, Brenner DA, Tu XM, Stärkel P, Pride D, Fouts DE, Schnabl B. PMID: 32654263; PMCID: PMC8159727.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    33. Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice. Exp Neurol. 2021 01; 335:113496. Sieverding K, Ulmer J, Bruno C, Satoh T, Tsao W, Freischmidt A, Akira S, Wong PC, Ludolph AC, Danzer KM, Lobsiger CS, Brenner D, Weishaupt JH. PMID: 33038415.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    34. Study of loneliness and wisdom in 482 middle-aged and oldest-old adults: a comparison between people in Cilento, Italy and San Diego, USA. Aging Ment Health. 2021 11; 25(11):2149-2159. Jeste DV, Di Somma S, Lee EE, Nguyen TT, Scalcione M, Biaggi A, Daly R, Liu J, Tu X, Ziedonis D, Glorioso D, Antonini P, Brenner D. PMID: 33000647; PMCID: PMC8012404.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    35. Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. Brain Commun. 2020; 2(2):fcaa133. Bruno C, Sieverding K, Freischmidt A, Satoh T, Walther P, Mayer B, Ludolph AC, Akira S, Yilmazer-Hanke D, Danzer KM, Lobsiger CS, Brenner D, Weishaupt JH. PMID: 33005894; PMCID: PMC7519725.
      View in: PubMed   Mentions: 5  
    36. Western Diet Promotes Renal Injury, Inflammation, and Fibrosis in a Murine Model of Alström Syndrome. Nephron. 2020; 144(8):400-412. Kim YC, Ganguly S, Nespoux J, Freeman B, Zhang H, Brenner D, Dhar D, Vallon V. PMID: 32629454; PMCID: PMC8011852.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    37. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Cell Metab. 2020 11 03; 32(5):878-888.e6. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T, Brenner DA, Sirlin CB, Downes M, Evans RM, Loomba R. PMID: 32610095; PMCID: PMC7822714.
      View in: PubMed   Mentions: 73     Fields:    Translation:Humans
    38. Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2α-dependent mechanism. Mol Metab. 2020 11; 41:101039. Riopel M, Moon JS, Bandyopadhyay GK, You S, Lam K, Liu X, Kisseleva T, Brenner D, Lee YS. PMID: 32534258; PMCID: PMC7393408.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    39. Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis. PLoS One. 2020; 15(6):e0234038. Baeza-Raja B, Goodyear A, Liu X, Lam K, Yamamoto L, Li Y, Dodson GS, Takeuchi T, Kisseleva T, Brenner DA, Dabbagh K. PMID: 32492075; PMCID: PMC7269334.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    40. Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). Medicina (Kaunas). 2020 May 05; 56(5). Pizza V, Antonini P, Marino R, D'Arena G, Lucibello SG, Rizzo M, Brenner DA, Jeste DV, Somma SD. PMID: 32380778; PMCID: PMC7279440.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    41. Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. Front Physiol. 2020; 11:370. Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L, Loomba R, Brenner DA, Stärkel P, Schnabl B. PMID: 32390870; PMCID: PMC7193112.
      View in: PubMed   Mentions: 10  
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    57. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. J Exp Med. 2019 02 04; 216(2):267-278. Brenner D, Sieverding K, Bruno C, Lüningschrör P, Buck E, Mungwa S, Fischer L, Brockmann SJ, Ulmer J, Bliederhäuser C, Philibert CE, Satoh T, Akira S, Boillée S, Mayer B, Sendtner M, Ludolph AC, Danzer KM, Lobsiger CS, Freischmidt A, Weishaupt JH. PMID: 30635357; PMCID: PMC6363427.
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    63. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Gastroenterology. 2019 03; 156(4):1156-1172.e6. Liang S, Ma HY, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T, Brenner DA. PMID: 30445007; PMCID: PMC6409207.
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    64. Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians. Clin Gastroenterol Hepatol. 2019 01; 17(2):218-230. Allaband C, McDonald D, Vázquez-Baeza Y, Minich JJ, Tripathi A, Brenner DA, Loomba R, Smarr L, Sandborn WJ, Schnabl B, Dorrestein P, Zarrinpar A, Knight R. PMID: 30240894; PMCID: PMC6391518.
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    66. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. Hepatology. 2018 09; 68(3):918-932. Caussy C, Hsu C, Lo MT, Liu A, Bettencourt R, Ajmera VH, Bassirian S, Hooker J, Sy E, Richards L, Schork N, Schnabl B, Brenner DA, Sirlin CB, Chen CH, Loomba R, Genetics of NAFLD in Twins Consortium. PMID: 29572891; PMCID: PMC6151296.
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    67. Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2. Hepatology. 2018 09; 68(3):1070-1086. Lan T, Li C, Yang G, Sun Y, Zhuang L, Ou Y, Li H, Wang G, Kisseleva T, Brenner D, Guo J. PMID: 29572892; PMCID: PMC6174945.
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    76. The fecal microbiome of ALS patients. Neurobiol Aging. 2018 01; 61:132-137. Brenner D, Hiergeist A, Adis C, Mayer B, Gessner A, Ludolph AC, Weishaupt JH. PMID: 29065369.
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    97. NEK1 mutations in familial amyotrophic lateral sclerosis. Brain. 2016 05; 139(Pt 5):e28. Brenner D, Müller K, Wieland T, Weydt P, Böhm S, Lulé D, Hübers A, Neuwirth C, Weber M, Borck G, Wahlqvist M, Danzer KM, Volk AE, Meitinger T, Strom TM, Otto M, Kassubek J, Ludolph AC, Andersen PM, Weishaupt JH. PMID: 26945885.
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    98. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. Ma HY, Xu J, Liu X, Zhu Y, Gao B, Karin M, Tsukamoto H, Jeste DV, Grant I, Roberts AJ, Contet C, Geoffroy C, Zheng B, Brenner D, Kisseleva T. PMID: 27239399; PMCID: PMC4878828.
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    99. Promising Therapy Candidates for Liver Fibrosis. Front Physiol. 2016; 7:47. Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH, Brenner DA, Kisseleva T. PMID: 26909046; PMCID: PMC4754444.
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    100. Liver: DNA methylation controls liver fibrogenesis. Nat Rev Gastroenterol Hepatol. 2016 Mar; 13(3):126-8. Liu X, Brenner DA. PMID: 26860269.
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    101. Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. Cell Host Microbe. 2016 Feb 10; 19(2):227-39. Wang L, Fouts DE, Stärkel P, Hartmann P, Chen P, Llorente C, DePew J, Moncera K, Ho SB, Brenner DA, Hooper LV, Schnabl B. PMID: 26867181; PMCID: PMC4786170.
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    102. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Front Physiol. 2016; 7:17. Liang S, Kisseleva T, Brenner DA. PMID: 26869935; PMCID: PMC4735448.
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    103. Staging of fibrosis in experimental non-alcoholic steatohepatitis by quantitative molecular imaging in rat models. Nucl Med Biol. 2016 Feb; 43(2):179-87. Schnabl B, Farshchi-Heydari S, Loomba R, Mattrey RF, Hoh CK, Sirlin CB, Brenner DA, Behling CA, Vera DR. PMID: 26872443.
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    104. Role of Gut Microbiota in Liver Disease. J Clin Gastroenterol. 2015 Nov-Dec; 49 Suppl 1:S25-7. Brenner DA, Paik YH, Schnabl B. PMID: 26447960; PMCID: PMC4602394.
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    105. Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion. J Clin Gastroenterol. 2015 Nov-Dec; 49 Suppl 1:S69-73. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS, Brenner DA, Qamar AA, Miloh TA, Guarino A, Guslandi M, Dieleman LA, Ringel Y, Quigley EM, Brandt LJ. PMID: 26447969.
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    106. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Gastroenterology. 2015 Dec; 149(7):1784-93. Loomba R, Schork N, Chen CH, Bettencourt R, Bhatt A, Ang B, Nguyen P, Hernandez C, Richards L, Salotti J, Lin S, Seki E, Nelson KE, Sirlin CB, Brenner D, Genetics of NAFLD in Twins Consortium. PMID: 26299412; PMCID: PMC4663110.
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    107. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. PLoS One. 2015; 10(7):e0129743. Lan T, Kisseleva T, Brenner DA. PMID: 26222337; PMCID: PMC4519306.
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    108. New therapies for hepatic fibrosis. Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S75-9. Koyama Y, Brenner DA. PMID: 26206573; PMCID: PMC4734896.
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    109. Novel association between serum pentraxin-2 levels and advanced fibrosis in well-characterised patients with non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2015 Sep; 42(5):582-90. Verna EC, Patel J, Bettencourt R, Nguyen P, Hernandez C, Valasek MA, Kisselva T, Brenner DA, Loomba R. PMID: 26119353; PMCID: PMC7979413.
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    110. Aging and liver disease. Curr Opin Gastroenterol. 2015 May; 31(3):184-91. Kim IH, Kisseleva T, Brenner DA. PMID: 25850346; PMCID: PMC4736713.
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    111. Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. Cell Death Differ. 2015 Nov; 22(11):1837-45. Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF, Brenner D, Harris IS, Chio II, Afzal S, Cairns RA, Cescon DW, Elford AR, Ye J, Lang PA, Li WY, Wakeham A, Duncan GS, Haight J, You-Ten A, Snow B, Yamamoto K, Ohashi PS, Mak TW. PMID: 25882048; PMCID: PMC4648331.
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    112. Recent advancement of molecular mechanisms of liver fibrosis. J Hepatobiliary Pancreat Sci. 2015 Jul; 22(7):512-8. Seki E, Brenner DA. PMID: 25869468; PMCID: PMC4668270.
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    113. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. J Exp Med. 2015 Apr 06; 212(4):469-80. Gao L, Brenner D, Llorens-Bobadilla E, Saiz-Castro G, Frank T, Wieghofer P, Hill O, Thiemann M, Karray S, Prinz M, Weishaupt JH, Martin-Villalba A. PMID: 25779632; PMCID: PMC4387281.
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    114. Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). Hepatology. 2015 Apr; 61(4):1239-50. Loomba R, Sirlin CB, Ang B, Bettencourt R, Jain R, Salotti J, Soaft L, Hooker J, Kono Y, Bhatt A, Hernandez L, Nguyen P, Noureddin M, Haufe W, Hooker C, Yin M, Ehman R, Lin GY, Valasek MA, Brenner DA, Richards L, San Diego Integrated NAFLD Research Consortium (SINC). PMID: 25482832; PMCID: PMC4407930.
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    115. Contribution of bone marrow-derived fibrocytes to liver fibrosis. Hepatobiliary Surg Nutr. 2015 Feb; 4(1):34-47. Xu J, Cong M, Park TJ, Scholten D, Brenner DA, Kisseleva T. PMID: 25713803; PMCID: PMC4318956.
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    116. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb; 21(2):159-65. Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M, Evans RM. PMID: 25559344; PMCID: PMC4320010.
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    117. Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice. FASEB J. 2015 Mar; 29(3):1043-55. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA, Miyamoto Y, Eckmann L, Dhungana S, Pathmasiri W, Sumner S, Westwater C, Brenner DA, Schnabl B. PMID: 25466902; PMCID: PMC4422368.
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    118. The accuracy of patient-reported measures for GI symptoms: a comparison of real time and retrospective reports. Neurogastroenterol Motil. 2014 Dec; 26(12):1802-11. Lackner JM, Jaccard J, Keefer L, Firth R, Carosella AM, Sitrin M, Brenner D, Representing the IBSOS Research Group. PMID: 25424582; PMCID: PMC4247164.
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    119. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. Hepatology. 2014 Dec; 60(6):1920-8. Loomba R, Wolfson T, Ang B, Hooker J, Behling C, Peterson M, Valasek M, Lin G, Brenner D, Gamst A, Ehman R, Sirlin C. PMID: 25103310; PMCID: PMC4245360.
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    120. Agreement between TOAST and CCS ischemic stroke classification: the NINDS SiGN study. Neurology. 2014 Oct 28; 83(18):1653-60. McArdle PF, Kittner SJ, Ay H, Brown RD, Meschia JF, Rundek T, Wassertheil-Smoller S, Woo D, Andsberg G, Biffi A, Brenner DA, Cole JW, Corriveau R, de Bakker PI, Delavaran H, Dichgans M, Grewal RP, Gwinn K, Huq M, Jern C, Jimenez-Conde J, Jood K, Kaplan RC, Katschnig P, Katsnelson M, Labovitz DL, Lemmens R, Li L, Lindgren A, Markus HS, Peddareddygari LR, Pedersén A, Pera J, Redfors P, Roquer J, Rosand J, Rost NS, Rothwell PM, Sacco RL, Sharma P, Slowik A, Sudlow C, Thijs V, Tiedt S, Valenti R, Worrall BB, NINDS SiGN Study. PMID: 25261504; PMCID: PMC4223086.
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    121. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. Cell Death Differ. 2015 Jan; 22(1):164-73. Lang PA, Meryk A, Pandyra AA, Brenner D, Brüstle A, Xu HC, Merches K, Lang F, Khairnar V, Sharma P, Funkner P, Recher M, Shaabani N, Duncan GS, Duhan V, Homey B, Ohashi PS, Häussinger D, Knolle PA, Honke N, Mak TW, Lang KS. PMID: 25257173; PMCID: PMC4262783.
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    122. New Approaches for Studying Alcoholic Liver Disease. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. Xu J, Liu X, Gao B, Karin M, Tsukamoto H, Brenner D, Kisseleva T. PMID: 26594598; PMCID: PMC4648354.
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    123. Origin of myofibroblasts in the fibrotic liver in mice. Proc Natl Acad Sci U S A. 2014 Aug 12; 111(32):E3297-305. Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA, Hofmann AF, Iida T, Glass CK, Brenner DA, Kisseleva T. PMID: 25074909; PMCID: PMC4136601.
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    124. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. Nat Commun. 2014 Jul 21; 5:4451. Lopez-Sanchez I, Dunkel Y, Roh YS, Mittal Y, De Minicis S, Muranyi A, Singh S, Shanmugam K, Aroonsakool N, Murray F, Ho SB, Seki E, Brenner DA, Ghosh P. PMID: 25043713; PMCID: PMC4107319.
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    125. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014 Aug; 124(8):3566-78. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner DA, Seki E. PMID: 24983318; PMCID: PMC4109552.
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    126. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. J Clin Invest. 2014 Jul; 124(7):2921-34. Moore-Morris T, Guimarães-Camboa N, Banerjee I, Zambon AC, Kisseleva T, Velayoudon A, Stallcup WB, Gu Y, Dalton ND, Cedenilla M, Gomez-Amaro R, Zhou B, Brenner DA, Peterson KL, Chen J, Evans SM. PMID: 24937432; PMCID: PMC4071409.
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    127. Achievement of optimal medical therapy goals for U.S. adults with coronary artery disease: results from the REGARDS Study (REasons for Geographic And Racial Differences in Stroke). J Am Coll Cardiol. 2014 Apr 29; 63(16):1626-33. Brown TM, Voeks JH, Bittner V, Brenner DA, Cushman M, Goff DC, Glasser S, Muntner P, Tabereaux PB, Safford MM. PMID: 24534599; PMCID: PMC4201851.
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    128. Role of NADPH oxidases in liver fibrosis. Antioxid Redox Signal. 2014 Jun 10; 20(17):2854-72. Paik YH, Kim J, Aoyama T, De Minicis S, Bataller R, Brenner DA. PMID: 24040957; PMCID: PMC4026397.
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    129. Transcriptional repression of the transforming growth factor β (TGF-β) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor κB (NF-κB) p50 enhances TGF-β signaling in hepatic stellate cells. J Biol Chem. 2014 Mar 07; 289(10):7082-7091. Liu C, Chen X, Yang L, Kisseleva T, Brenner DA, Seki E. PMID: 24448807; PMCID: PMC3945368.
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    130. Interactions between the intestinal microbiome and liver diseases. Gastroenterology. 2014 May; 146(6):1513-24. Schnabl B, Brenner DA. PMID: 24440671; PMCID: PMC3996054.
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    131. Fra, Fra away: the complex role of activator protein 1 in liver injury. Hepatology. 2014 Jan; 59(1):19-20. Brenner DA. PMID: 23904356.
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    132. Reversibility of liver fibrosis. Gastroenterol Hepatol (N Y). 2013 Nov; 9(11):737-9. Brenner DA. PMID: 24764791; PMCID: PMC3995196.
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    133. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Hepatology. 2013 Dec; 58(6):1930-40. Noureddin M, Lam J, Peterson MR, Middleton M, Hamilton G, Le TA, Bettencourt R, Changchien C, Brenner DA, Sirlin C, Loomba R. PMID: 23696515; PMCID: PMC4819962.
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    134. Development of exchange lists for Mediterranean and Healthy Eating diets: implementation in an intervention trial. J Hum Nutr Diet. 2014 Oct; 27(5):413-25. Sidahmed E, Cornellier ML, Ren J, Askew LM, Li Y, Talaat N, Rapai MS, Ruffin MT, Turgeon DK, Brenner D, Sen A, Djuric Z. PMID: 24112099; PMCID: PMC3961569.
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    135. M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. J Cell Biol. 2013 Sep 16; 202(6):951-66. Madsen DH, Leonard D, Masedunskas A, Moyer A, Jürgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS, Brenner DA, Burgdorf S, Engelholm LH, Behrendt N, Holmbeck K, Weigert R, Bugge TH. PMID: 24019537; PMCID: PMC3776354.
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    136. Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. Curr Pathobiol Rep. 2013 Sep; 1(3):209-214. Liu X, Xu J, Brenner DA, Kisseleva T. PMID: 24000319; PMCID: PMC3757252.
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    137. Semaphorin 7A contributes to TGF-β-mediated liver fibrogenesis. Am J Pathol. 2013 Sep; 183(3):820-30. De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Millán C, Brenner DA, Vivarelli M, Mocchegiani F, Marzioni M, Benedetti A, Svegliati-Baroni G. PMID: 23850082; PMCID: PMC5819760.
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    138. Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships. Gastroenterology. 2013 Jul; 145(1):16-31. Fordtran JS, Goyal RK, Feldman M, Soll AH, Trier JS, Ockner RK, LaRusso NF, Podolsky DK, Brenner DA, Rustgi AK, Omary MB. PMID: 23806784.
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    139. Evidence for a common progenitor of epithelial and mesenchymal components of the liver. Cell Death Differ. 2013 Aug; 20(8):1116-23. Conigliaro A, Amicone L, Costa V, De Santis Puzzonia M, Mancone C, Sacchetti B, Cicchini C, Garibaldi F, Brenner DA, Kisseleva T, Bianco P, Tripodi M. PMID: 23686136; PMCID: PMC3705603.
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    140. Synergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma. Clin Gastroenterol Hepatol. 2013 Dec; 11(12):1636-45.e1-3. Loomba R, Liu J, Yang HI, Lee MH, Lu SN, Wang LY, Iloeje UH, You SL, Brenner D, Chen CJ, REVEAL–HBV Study Group. PMID: 23669307; PMCID: PMC4100777.
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    141. Serum γ-glutamyltranspeptidase predicts all-cause, cardiovascular and liver mortality in older adults. J Clin Exp Hepatol. 2013 Mar 01; 3(1):4-11. Loomba R, Doycheva I, Bettencourt R, Cohen B, Wassel CL, Brenner D, Barrett-Connor E. PMID: 23997501; PMCID: PMC3940213.
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    142. Kenji Fujiwara, MD, PhD. Gastroenterology. 2013 Apr; 144(4):661-3. Sugano K, Podolsky DK, Brenner DA, Michalopoulos G, Tsukamoto H. PMID: 23499284.
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    143. Overexpression of endoglin modulates TGF-β1-signalling pathways in a novel immortalized mouse hepatic stellate cell line. PLoS One. 2013; 8(2):e56116. Meurer SK, Alsamman M, Sahin H, Wasmuth HE, Kisseleva T, Brenner DA, Trautwein C, Weiskirchen R, Scholten D. PMID: 23437087; PMCID: PMC3577806.
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    144. Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2013 Mar; 37(6):630-9. Patel NS, Peterson MR, Brenner DA, Heba E, Sirlin C, Loomba R. PMID: 23383649; PMCID: PMC4136524.
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    145. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Hepatology. 2013 Feb; 57(2):577-89. Miura K, Yang L, van Rooijen N, Brenner DA, Ohnishi H, Seki E. PMID: 22987396; PMCID: PMC3566276.
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    146. Synergism between obesity and alcohol in increasing the risk of hepatocellular carcinoma: a prospective cohort study. Am J Epidemiol. 2013 02 15; 177(4):333-42. Loomba R, Yang HI, Su J, Brenner D, Barrett-Connor E, Iloeje U, Chen CJ. PMID: 23355498; PMCID: PMC3626057.
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    147. Reactive oxygen species delay control of lymphocytic choriomeningitis virus. Cell Death Differ. 2013 Apr; 20(4):649-58. Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA, Harris IS, Shaabani N, Honke N, Maney SK, Lang E, Pozdeev VI, Recher M, Odermatt B, Brenner D, Häussinger D, Ohashi PS, Hengartner H, Zinkernagel RM, Mak TW, Lang KS. PMID: 23328631; PMCID: PMC3595491.
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    148. Inactivation of myofibroblasts during regression of liver fibrosis. Cell Cycle. 2013 Feb 01; 12(3):381-2. Kisseleva T, Brenner DA. PMID: 23324345; PMCID: PMC3587431.
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    149. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology. 2012 Dec; 56(6):2316-27. Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C, Page P, Brenner DA. PMID: 22806357; PMCID: PMC3493679.
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    150. Liver carcinogenesis: rodent models of hepatocarcinoma and cholangiocarcinoma. Dig Liver Dis. 2013 Jun; 45(6):450-9. De Minicis S, Kisseleva T, Francis H, Baroni GS, Benedetti A, Brenner D, Alvaro D, Alpini G, Marzioni M. PMID: 23177172; PMCID: PMC3716909.
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    151. Next-generation academic medicine. J Clin Invest. 2012 Nov; 122(11):4280-2. Brenner DA. PMID: 23114607; PMCID: PMC3484473.
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    152. Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. Nat Immunol. 2012 Nov; 13(11):1072-82. Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E, Brenner DA, Apte RN, Jung S, Lapidot T. PMID: 22983360.
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    153. The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2. Allergy. 2012 Nov; 67(11):1357-64. Campos Alberto E, Maclean E, Davidson C, Palikhe NS, Storie J, Tse C, Brenner D, Mayers I, Vliagoftis H, El-Sohemy A, Cameron L. PMID: 22947041.
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    154. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. Gastroenterology. 2012 Nov; 143(5):1330-1340.e1. Hartmann P, Haimerl M, Mazagova M, Brenner DA, Schnabl B. PMID: 22841787; PMCID: PMC3482543.
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    155. Identification of small molecule activators of cryptochrome. Science. 2012 Aug 31; 337(6098):1094-7. Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T, Welsh DK, Brenner DA, Doyle FJ, Schultz PG, Kay SA. PMID: 22798407; PMCID: PMC3589997.
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    156. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Hepatology. 2012 Sep; 56(3):922-32. Le TA, Chen J, Changchien C, Peterson MR, Kono Y, Patton H, Cohen BL, Brenner D, Sirlin C, Loomba R, San Diego Integrated NAFLD Research Consortium (SINC). PMID: 22431131; PMCID: PMC3400720.
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    157. Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis. Gut. 2013 Mar; 62(3):335-6. Schnabl B, Brenner DA. PMID: 22717452; PMCID: PMC4077319.
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    158. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology. 2012 Aug; 143(2):307-20. Seki E, Brenner DA, Karin M. PMID: 22705006; PMCID: PMC3523093.
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    159. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Gastroenterology. 2012 Sep; 143(3):765-776.e3. Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, Österreicher CH, Stickel F, Ley K, Brenner DA, Kisseleva T. PMID: 22687286; PMCID: PMC3635475.
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    160. Origin of myofibroblasts in liver fibrosis. Fibrogenesis Tissue Repair. 2012; 5(Suppl 1):S17. Brenner DA, Kisseleva T, Scholten D, Paik YH, Iwaisako K, Inokuchi S, Schnabl B, Seki E, De Minicis S, Oesterreicher C, Taura K. PMID: 23259769; PMCID: PMC3368775.
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    161. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):9448-53. Kisseleva T, Cong M, Paik Y, Scholten D, Jiang C, Benner C, Iwaisako K, Moore-Morris T, Scott B, Tsukamoto H, Evans SM, Dillmann W, Glass CK, Brenner DA. PMID: 22566629; PMCID: PMC3386114.
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    162. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. Aliment Pharmacol Ther. 2012 Jul; 36(1):22-9. Permutt Z, Le TA, Peterson MR, Seki E, Brenner DA, Sirlin C, Loomba R. PMID: 22554256; PMCID: PMC3437221.
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    163. Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist. Proc Natl Acad Sci U S A. 2012 May 22; 109(21):E1369-76. Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y, Sirlin C, Yu E, Yu RT, Downes M, Evans RM, Brenner DA, Schnabl B. PMID: 22538808; PMCID: PMC3361396.
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    164. Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study. PLoS One. 2012; 7(4):e34218. Lee JK, Bettencourt R, Brenner D, Le TA, Barrett-Connor E, Loomba R. PMID: 22514624; PMCID: PMC3325993.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    165. What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:65-8. Iwaisako K, Brenner DA, Kisseleva T. PMID: 22320919; PMCID: PMC4841268.
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    166. Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease. J Hepatol. 2012 Jun; 56(6):1283-92. Fouts DE, Torralba M, Nelson KE, Brenner DA, Schnabl B. PMID: 22326468; PMCID: PMC3357486.
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    167. Diagnosis and management of patients with α1-antitrypsin (A1AT) deficiency. Clin Gastroenterol Hepatol. 2012 Jun; 10(6):575-80. Nelson DR, Teckman J, Di Bisceglie AM, Brenner DA. PMID: 22200689; PMCID: PMC3360829.
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    168. The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis. J Hepatol. 2012 Apr; 56(4):965-72. Kisseleva T, Brenner DA. PMID: 22173163; PMCID: PMC3307836.
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    169. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. Korean J Hepatol. 2011 Dec; 17(4):251-7. Paik YH, Brenner DA. PMID: 22310788; PMCID: PMC3304665.
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    170. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. Clin Gastroenterol Hepatol. 2012 Mar; 10(3):285-90.e1. Dong MH, Bettencourt R, Brenner DA, Barrett-Connor E, Loomba R. PMID: 22020064; PMCID: PMC3288181.
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    171. Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. Hepatol Res. 2011 Jul; 41(7):683-6. Brenner DA, Seki E, Taura K, Kisseleva T, Deminicis S, Iwaisako K, Inokuchi S, Schnabl B, Oesterreicher CH, Paik YH, Miura K, Kodama Y. PMID: 21711427; PMCID: PMC3341613.
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    172. Migration of fibrocytes in fibrogenic liver injury. Am J Pathol. 2011 Jul; 179(1):189-98. Scholten D, Reichart D, Paik YH, Lindert J, Bhattacharya J, Glass CK, Brenner DA, Kisseleva T. PMID: 21703401; PMCID: PMC3123781.
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    173. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Hepatology. 2011 May; 53(5):1730-41. Paik YH, Iwaisako K, Seki E, Inokuchi S, Schnabl B, Osterreicher CH, Kisseleva T, Brenner DA. PMID: 21384410; PMCID: PMC3082608.
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    174. Is it the end of the line for the EMT? Hepatology. 2011 May; 53(5):1433-5. Kisseleva T, Brenner DA. PMID: 21433040.
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    175. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Liver Int. 2011 Jul; 31(6):762-72. DeLeve LD, Jaeschke H, Kalra VK, Asahina K, Brenner DA, Tsukamoto H. PMID: 21645207; PMCID: PMC4388239.
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    176. Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection. J Mol Med (Berl). 2011 Oct; 89(10):997-1013. Kisseleva T, von Köckritz-Blickwede M, Reichart D, McGillvray SM, Wingender G, Kronenberg M, Glass CK, Nizet V, Brenner DA. PMID: 21499735; PMCID: PMC3171633.
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    177. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol Clin Exp Res. 2011 Aug; 35(8):1509-18. Inokuchi S, Tsukamoto H, Park E, Liu ZX, Brenner DA, Seki E. PMID: 21463341; PMCID: PMC3131439.
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    178. Anti-fibrogenic strategies and the regression of fibrosis. Best Pract Res Clin Gastroenterol. 2011 Apr; 25(2):305-17. Kisseleva T, Brenner DA. PMID: 21497747; PMCID: PMC3086317.
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    179. Alteration of interferon-α/β receptors in chronic hepatitis B patients. J Clin Immunol. 2011 Jun; 31(3):521-32. Meng F, Wang J, Ge J, Fan X, Wang B, Han L, Kisseleva T, Paik Y, Brenner DA, Wang K. PMID: 21445562; PMCID: PMC4795458.
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    180. Innate immunity in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol. 2011 Apr; 300(4):G516-25. Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, Nagy L, Szabo G, Zakhari S. PMID: 21252049; PMCID: PMC3774265.
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    181. Role of toll-like receptors and their downstream molecules in the development of nonalcoholic Fatty liver disease. Gastroenterol Res Pract. 2010; 2010:362847. Miura K, Seki E, Ohnishi H, Brenner DA. PMID: 21274430; PMCID: PMC3026974.
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    182. What goes up must come down: the emerging role of microRNA in fibrosis. Hepatology. 2011 Jan; 53(1):4-6. Chau BN, Brenner DA. PMID: 21254156.
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    183. Mutation of the 5'-untranslated region stem-loop structure inhibits α1(I) collagen expression in vivo. J Biol Chem. 2011 Mar 11; 286(10):8609-8619. Parsons CJ, Stefanovic B, Seki E, Aoyama T, Latour AM, Marzluff WF, Rippe RA, Brenner DA. PMID: 21193410; PMCID: PMC3048743.
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    184. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):308-13. Österreicher CH, Penz-Österreicher M, Grivennikov SI, Guma M, Koltsova EK, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA. PMID: 21173249; PMCID: PMC3017162.
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    185. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. FASEB J. 2011 Apr; 25(4):1133-44. Osawa Y, Seki E, Kodama Y, Suetsugu A, Miura K, Adachi M, Ito H, Shiratori Y, Banno Y, Olefsky JM, Nagaki M, Moriwaki H, Brenner DA, Seishima M. PMID: 21163859; PMCID: PMC3058702.
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    186. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Hepatology. 2011 Jan; 53(1):96-105. Yan AW, Fouts DE, Brandl J, Stärkel P, Torralba M, Schott E, Tsukamoto H, Nelson KE, Brenner DA, Schnabl B. PMID: 21254165; PMCID: PMC3059122.
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    187. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Hepatology. 2010 Oct; 52(4):1420-30. De Minicis S, Seki E, Paik YH, Osterreicher CH, Kodama Y, Kluwe J, Torozzi L, Miyai K, Benedetti A, Schwabe RF, Brenner DA. PMID: 20690191; PMCID: PMC2947612.
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    188. CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. Hepatology. 2010 Oct; 52(4):1390-400. Aoyama T, Inokuchi S, Brenner DA, Seki E. PMID: 20683935; PMCID: PMC2947579.
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    189. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med. 2010 Oct; 16(10):1152-6. Zhang EE, Liu Y, Dentin R, Pongsawakul PY, Liu AC, Hirota T, Nusinow DA, Sun X, Landais S, Kodama Y, Brenner DA, Montminy M, Kay SA. PMID: 20852621; PMCID: PMC2952072.
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    190. Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. Clin Gastroenterol Hepatol. 2010 Oct; 8(10):891-8, 898.e1-2. Loomba R, Yang HI, Su J, Brenner D, Iloeje U, Chen CJ. PMID: 20621202.
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    191. Recent advances in liver stem cell therapy. Curr Opin Gastroenterol. 2010 Jul; 26(4):395-402. Kisseleva T, Gigante E, Brenner DA. PMID: 20495456.
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    192. Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Gastroenterology. 2010 Sep; 139(3):987-98. Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G, Brenner DA, Kisseleva T. PMID: 20546735; PMCID: PMC2930026.
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    193. Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins. Gastroenterology. 2010 Sep; 139(3):836-45, 845.e1. Loomba R, Rao F, Zhang L, Khandrika S, Ziegler MG, Brenner DA, O'Connor DT. PMID: 20537997; PMCID: PMC3038676.
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    194. Awareness, treatment, and control of vascular risk factors among stroke survivors. J Stroke Cerebrovasc Dis. 2010 Jul-Aug; 19(4):311-20. Brenner DA, Zweifler RM, Gomez CR, Kissela BM, Levine D, Howard G, Coull B, Howard VJ. PMID: 20472464; PMCID: PMC3606552.
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    195. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology. 2010 Jul; 139(1):323-34.e7. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H, Olefsky JM, Brenner DA, Seki E. PMID: 20347818; PMCID: PMC4631262.
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    196. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology. 2010 Mar; 51(3):1027-36. Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M, Brenner DA. PMID: 20052656; PMCID: PMC2906231.
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    197. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. Hepatology. 2010 Mar; 51(3):942-52. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K, Brenner DA, Ginès P, Bataller R. PMID: 20044807.
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    198. Hepatic progenitors for liver disease: current position. Stem Cells Cloning. 2010 Feb 25; 3:39-47. Conigliaro A, Brenner DA, Kisseleva T. PMID: 24198509; PMCID: PMC3781731.
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    199. Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. Liver Transpl. 2010 Feb; 16(2):181-90. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA, Brenner DA, Lemasters JJ. PMID: 20104486; PMCID: PMC2834418.
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    200. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):844-9. Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S, Brenner DA, Seki E. PMID: 20080763; PMCID: PMC2818947.
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    201. Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells. Liver Int. 2010 Jan; 30(1):31-41. Sancho-Bru P, Juez E, Moreno M, Khurdayan V, Morales-Ruiz M, Colmenero J, Arroyo V, Brenner DA, Ginès P, Bataller R. PMID: 19929904.
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    202. Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology. 2009 Sep; 50(3):929-38. Osterreicher CH, Taura K, De Minicis S, Seki E, Penz-Osterreicher M, Kodama Y, Kluwe J, Schuster M, Oudit GY, Penninger JM, Brenner DA. PMID: 19650157; PMCID: PMC4734904.
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    203. Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Integr Biol (Camb). 2009 Sep; 1(8-9):513-24. Brafman DA, de Minicis S, Seki E, Shah KD, Teng D, Brenner D, Willert K, Chien S. PMID: 20023766.
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    204. Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Am J Physiol Gastrointest Liver Physiol. 2009 Oct; 297(4):G726-34. Colmenero J, Bataller R, Sancho-Bru P, Domínguez M, Moreno M, Forns X, Bruguera M, Arroyo V, Brenner DA, Ginès P. PMID: 19628656; PMCID: PMC2763804.
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    205. CCR2 promotes hepatic fibrosis in mice. Hepatology. 2009 Jul; 50(1):185-97. Seki E, de Minicis S, Inokuchi S, Taura K, Miyai K, van Rooijen N, Schwabe RF, Brenner DA. PMID: 19441102; PMCID: PMC2705470.
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    206. CCR1 and CCR5 promote hepatic fibrosis in mice. J Clin Invest. 2009 Jul; 119(7):1858-70. Seki E, De Minicis S, Gwak GY, Kluwe J, Inokuchi S, Bursill CA, Llovet JM, Brenner DA, Schwabe RF. PMID: 19603542; PMCID: PMC2701864.
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    207. c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. Gastroenterology. 2009 Oct; 137(4):1467-1477.e5. Kodama Y, Kisseleva T, Iwaisako K, Miura K, Taura K, De Minicis S, Osterreicher CH, Schnabl B, Seki E, Brenner DA. PMID: 19549522; PMCID: PMC2757473.
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    208. Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease. Stroke. 2009 May; 40(5):1721-8. Lavallée PC, Labreuche J, Gongora-Rivera F, Jaramillo A, Brenner D, Klein IF, Touboul PJ, Vicaut E, Amarenco P, Lacunar-BICHAT Investigators. PMID: 19286582.
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    209. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Proc Natl Acad Sci U S A. 2009 Mar 03; 106(9):3300-5. Brandl K, Rutschmann S, Li X, Du X, Xiao N, Schnabl B, Brenner DA, Beutler B. PMID: 19202076; PMCID: PMC2651297.
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    210. Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats. Gut. 2009 Nov; 58(11):1517-27. Paik YH, Kim JK, Lee JI, Kang SH, Kim DY, An SH, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Lee KS, Brenner DA. PMID: 19201774.
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    211. The enteropathy of prostaglandin deficiency. J Gastroenterol. 2009; 44 Suppl 19:1-7. Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA, Brenner DA, Milne GL, Morrow JD, Boutaud O, Oates JA. PMID: 19148786; PMCID: PMC2799331.
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    212. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. Gastroenterology. 2009 Apr; 136(4):1423-34. Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y, Brenner DA. PMID: 19249395.
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    213. Molecular pathogenesis of liver fibrosis. Trans Am Clin Climatol Assoc. 2009; 120:361-8. Brenner DA. PMID: 19768189; PMCID: PMC2744540.
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    214. c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps. Hepatology. 2009 Jan; 49(1):6-8. Kodama Y, Brenner DA. PMID: 19111006.
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    215. Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. Hepatology. 2008 Dec; 48(6):2016-26. De Minicis S, Seki E, Oesterreicher C, Schnabl B, Schwabe RF, Brenner DA. PMID: 19025999.
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    216. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol. 2008 Dec; 173(6):1617-27. Lin SL, Kisseleva T, Brenner DA, Duffield JS. PMID: 19008372; PMCID: PMC2626374.
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    217. TNFalpha is required for cholestasis-induced liver fibrosis in the mouse. Biochem Biophys Res Commun. 2009 Jan 16; 378(3):348-53. Gäbele E, Froh M, Arteel GE, Uesugi T, Hellerbrand C, Schölmerich J, Brenner DA, Thurman RG, Rippe RA. PMID: 18996089; PMCID: PMC5052129.
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    218. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Hepatology. 2008 Nov; 48(5):1420-9. Miura K, Taura K, Kodama Y, Schnabl B, Brenner DA. PMID: 18671304.
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    219. NK and NKT cells in liver injury and fibrosis. Clin Immunol. 2009 Jan; 130(1):16-26. Notas G, Kisseleva T, Brenner D. PMID: 18823822.
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    220. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Gastroenterology. 2008 Nov; 135(5):1729-38. Taura K, De Minicis S, Seki E, Hatano E, Iwaisako K, Osterreicher CH, Kodama Y, Miura K, Ikai I, Uemoto S, Brenner DA. PMID: 18823985.
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    221. What is the potential role of antifibrotic agents for the treatment of liver disease? Nat Clin Pract Gastroenterol Hepatol. 2008 Sep; 5(9):496-7. Schnabl B, Scholten D, Brenner DA. PMID: 18628735.
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    222. Toll-like receptors and adaptor molecules in liver disease: update. Hepatology. 2008 Jul; 48(1):322-35. Seki E, Brenner DA. PMID: 18506843.
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    223. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. J Clin Invest. 2008 Jun; 118(6):2121-31. Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA, Brenner DA, Morrow JD, Boutaud O, Oates JA. PMID: 18451993; PMCID: PMC2350426.
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    224. Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. Alcohol. 2008 Aug; 42(5):349-61. Purohit V, Bode JC, Bode C, Brenner DA, Choudhry MA, Hamilton F, Kang YJ, Keshavarzian A, Rao R, Sartor RB, Swanson C, Turner JR. PMID: 18504085; PMCID: PMC2614138.
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    225. The renin-angiotensin-aldosterone system in cerebral small vessel disease. J Neurol. 2008 Jul; 255(7):993-1000. Brenner D, Labreuche J, Pico F, Scheltens P, Poirier O, Cambien F, Amarenco P, GENIC Investigators. PMID: 18446309.
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    226. Fibrogenesis of parenchymal organs. Proc Am Thorac Soc. 2008 Apr 15; 5(3):338-42. Kisseleva T, Brenner DA. PMID: 18403330; PMCID: PMC2645245.
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    227. Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. J Gastroenterol Hepatol. 2008 Mar; 23 Suppl 1:S98-103. De Minicis S, Brenner DA. PMID: 18336675.
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    228. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. Hepatology. 2008 Feb; 47(2):677-85. Adachi M, Brenner DA. PMID: 18220291.
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    229. Mechanisms of fibrogenesis. Exp Biol Med (Maywood). 2008 Feb; 233(2):109-22. Kisseleva T, Brenner DA. PMID: 18222966.
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    230. Alzheimer's disease: the vascular connection. Int J Stroke. 2007 Nov; 2(4):243-4. Brenner DA, Alexandrov AV. PMID: 18705924.
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    231. Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. Hepatology. 2007 Nov; 46(5):1443-52. Mencin A, Seki E, Osawa Y, Kodama Y, De Minicis S, Knowles M, Brenner DA. PMID: 17668872.
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    232. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med. 2007 Nov; 13(11):1324-32. Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, Schwabe RF. PMID: 17952090.
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    233. Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. Gastroenterology. 2007 Dec; 133(6):2019-28. Sancho-Bru P, Bataller R, Fernandez-Varo G, Moreno M, Ramalho LN, Colmenero J, Marí M, Clària J, Jiménez W, Arroyo V, Brenner DA, Ginès P. PMID: 18054572.
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    234. Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB. J Hepatol. 2007 Dec; 47(6):834-43. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y, Brenner DA, Watanabe S. PMID: 17935821.
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    235. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. J Theor Biol. 2007 Dec 07; 249(3):518-31. Sachs RK, Shuryak I, Brenner D, Fakir H, Hlatky L, Hahnfeldt P. PMID: 17897680; PMCID: PMC2169295.
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    236. Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course. J Gastroenterol Hepatol. 2007 Aug; 22(8):1256-64. Tacke F, Trautwein C, Yagmur E, Hellerbrand C, Wiest R, Brenner DA, Schnabl B. PMID: 17688666.
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    237. Matrix metalloproteinase gene delivery for liver fibrosis. Pharm Res. 2008 Feb; 25(2):249-58. Iimuro Y, Brenner DA. PMID: 17577645; PMCID: PMC2245995.
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    238. Nuclear factor-kappaB in the liver: friend or foe? Gastroenterology. 2007 Jun; 132(7):2601-4. Schwabe RF, Brenner DA. PMID: 17570232.
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    239. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. J Gastroenterol Hepatol. 2007 Jun; 22 Suppl 1:S73-8. Kisseleva T, Brenner DA. PMID: 17567473.
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    240. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? J Hepatol. 2007 Aug; 47(2):307-9. Seki E, Brenner DA. PMID: 17566588; PMCID: PMC2739234.
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    241. NOX in liver fibrosis. Arch Biochem Biophys. 2007 Jun 15; 462(2):266-72. De Minicis S, Brenner DA. PMID: 17531188; PMCID: PMC2727549.
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    242. Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force. Gastroenterology. 2007 May; 132(6):2272-5. Kaplan LM, Klein S, Boden G, Brenner DA, Gostout CJ, Lavine JE, Popkin BM, Schirmer BD, Seeley RJ, Yanovski SZ, Cominelli F. PMID: 17498517.
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    243. Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. Dig Dis Sci. 2007 Dec; 52(12):3404-15. Tacke F, Gäbele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C, Brenner DA, Schölmerich J, Schnabl B. PMID: 17415633.
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    244. The genetics of nonalcoholic fatty liver disease. Ann Hepatol. 2007 Apr-Jun; 6(2):83-8. Osterreicher CH, Brenner DA. PMID: 17519829.
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    245. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology. 2007 May; 132(5):1937-46. De Minicis S, Seki E, Uchinami H, Kluwe J, Zhang Y, Brenner DA, Schwabe RF. PMID: 17484886.
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    246. Genomics of liver fibrosis and cirrhosis. Semin Liver Dis. 2007 Feb; 27(1):28-43. Osterreicher CH, Stickel F, Brenner DA. PMID: 17295175.
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    247. The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. Gastroenterology. 2007 Apr; 132(4):1434-46. Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D, Brenner DA. PMID: 17408630.
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    248. Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. Liver Int. 2006 Nov; 26(9):1138-47. Osawa Y, Seki E, Adachi M, Taura K, Kodama Y, Siegmund SV, Schwabe RF, Brenner DA. PMID: 17032415.
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    249. Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation. Cell Death Differ. 2007 Mar; 14(3):568-75. Arnold R, Frey CR, Müller W, Brenner D, Krammer PH, Kiefer F. PMID: 17024227.
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    250. Hepatic stellate cells and the reversal of fibrosis. J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S84-7. Kisseleva T, Brenner DA. PMID: 16958681.
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    251. Immunosuppression, hepatitis B virus variants: Synergistic role in hepatic fibrogenesis. Gastroenterology. 2006 Sep; 131(3):957-60. Paik YH, Brenner DA. PMID: 16952565.
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    252. The Clinical Research Forum and Association of American Physicians disagree with criticism of the NIH Roadmap. J Clin Invest. 2006 Aug; 116(8):2058-9. Crowley W, Courtney J, Jameson L, Pardes H, Moskowitz J, Orringer E, Rubenstein A, Wood A, Rettig R, Ausiello D, Brenner D, Collins F, Elias J, Greene W, Horowitz R, Jameson L, Kieff E, Thompson C, Swain JL. PMID: 16886049; PMCID: PMC1523419.
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    253. Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis. Hepatology. 2006 Aug; 44(2):420-9. Uchinami H, Seki E, Brenner DA, D'Armiento J. PMID: 16871591.
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    254. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. Transplantation. 2006 Jul 27; 82(2):241-50. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H, Brenner DA, Lemasters JJ. PMID: 16858288.
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    255. NADPH oxidase in the liver: defensive, offensive, or fibrogenic? Gastroenterology. 2006 Jul; 131(1):272-5. De Minicis S, Bataller R, Brenner DA. PMID: 16831609.
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    256. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2006 Nov; 291(5):G877-84. Sancho-Bru P, Bataller R, Colmenero J, Gasull X, Moreno M, Arroyo V, Brenner DA, Ginès P. PMID: 16782692.
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    257. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. J Hepatol. 2006 Sep; 45(3):429-38. Kisseleva T, Uchinami H, Feirt N, Quintana-Bustamante O, Segovia JC, Schwabe RF, Brenner DA. PMID: 16846660.
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    258. Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients. Stroke. 2006 Jul; 37(7):1691-6. Brenner D, Labreuche J, Touboul PJ, Schmidt-Petersen K, Poirier O, Perret C, Schönfelder J, Combadière C, Lathrop M, Cambien F, Brand-Herrmann SM, Amarenco P, GENIC Investigators. PMID: 16741188.
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    259. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Gastroenterology. 2006 May; 130(6):1564-72. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N, Seki E, Brenner D, Korenblat K, McCrea J. PMID: 16697719.
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    260. Toll-like receptor signaling in the liver. Gastroenterology. 2006 May; 130(6):1886-900. Schwabe RF, Seki E, Brenner DA. PMID: 16697751.
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    261. The future of gastroenterology and gastroenterology. Gastroenterology. 2006 May; 130(6):1562. Brenner DA. PMID: 16697718.
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    262. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. Lab Invest. 2006 Jul; 86(7):676-86. Paik YH, Lee KS, Lee HJ, Yang KM, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Moon YM, Brenner DA. PMID: 16619004.
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    263. Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation. Am J Physiol Gastrointest Liver Physiol. 2006 Sep; 291(3):G456-63. Lehnert M, Uehara T, Bradford BU, Lind H, Zhong Z, Brenner DA, Marzi I, Lemasters JJ. PMID: 16614372.
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    264. Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol. 2006 Apr; 290(4):G583-9. Schwabe RF, Brenner DA. PMID: 16537970.
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    265. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. Liver Transpl. 2006 Apr; 12(4):550-9. Lehmann TG, Luedde T, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ, Brenner DA. PMID: 16555330.
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    266. Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium. Hepatology. 2006 Apr; 43(4):872-8. Purohit V, Brenner DA. PMID: 16502397.
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    267. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Hepatology. 2005 Dec; 42(6):1320-8. Osawa Y, Hannun YA, Proia RL, Brenner DA. PMID: 16317686.
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    268. Molecular pathogenesis of alcohol-induced hepatic fibrosis. Alcohol Clin Exp Res. 2005 Nov; 29(11 Suppl):102S-109S. Siegmund SV, Brenner DA. PMID: 16344593.
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    269. Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. Biochem Biophys Res Commun. 2005 Sep 16; 335(1):87-96. Schnabl B, Hu K, Mühlbauer M, Hellerbrand C, Stefanovic B, Brenner DA, Schölmerich J. PMID: 16054593.
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    270. Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. Exp Biol Med (Maywood). 2005 Sep; 230(8):573-86. Stefanovic L, Brenner DA, Stefanovic B. PMID: 16118408.
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    271. Liver fibrogenesis: a new role for the renin-angiotensin system. Antioxid Redox Signal. 2005 Sep-Oct; 7(9-10):1346-55. Bataller R, Sancho-Bru P, Ginès P, Brenner DA. PMID: 16115040.
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    272. Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. J Hepatol. 2005 Aug; 43(2):317-23. Yang L, Bataller R, Dulyx J, Coffman TM, Ginès P, Rippe RA, Brenner DA. PMID: 15964094.
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    273. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem. 2005 Jul 29; 280(30):27879-87. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA, Brenner DA. PMID: 15946935.
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    274. NF-kappaB activation in Kupffer cells after partial hepatectomy. Am J Physiol Gastrointest Liver Physiol. 2005 Sep; 289(3):G530-8. Yang L, Magness ST, Bataller R, Rippe RA, Brenner DA. PMID: 15905413.
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    275. Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats. Hepatology. 2005 May; 41(5):1046-55. Bataller R, Gäbele E, Parsons CJ, Morris T, Yang L, Schoonhoven R, Brenner DA, Rippe RA. PMID: 15841463.
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    276. Anandamide induces necrosis in primary hepatic stellate cells. Hepatology. 2005 May; 41(5):1085-95. Siegmund SV, Uchinami H, Osawa Y, Brenner DA, Schwabe RF. PMID: 15841466.
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    277. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. J Biol Chem. 2005 Jun 10; 280(23):21763-72. Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R, Brenner DA, Tabas I. PMID: 15826936.
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    278. JNK mediates hepatic ischemia reperfusion injury. J Hepatol. 2005 Jun; 42(6):850-9. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK, Brenner DA. PMID: 15885356.
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    279. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J Clin Invest. 2005 Apr; 115(4):849-59. Luedde T, Assmus U, Wüstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K, Brenner DA, Manns MP, Pasparakis M, Trautwein C. PMID: 15776110; PMCID: PMC1064982.
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    280. Information assimilation and distribution challenges and goals for real and virtual journals. J Clin Gastroenterol. 2005 Mar; 39(3):181-8. Modlin IM, Adler G, Alexander K, Arnold R, Brenner DA, Corazziari E, Floch MH, LaPorte RE, Peterson WL, Quigley EM, Shapiro MD, Spechler SJ, Spiller RC, Tytgat GN, Wiegers W. PMID: 15718859.
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    281. Liver fibrosis. J Clin Invest. 2005 Feb; 115(2):209-18. Bataller R, Brenner DA. PMID: 15690074; PMCID: PMC546435.
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    282. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. J Biol Chem. 2005 Apr 08; 280(14):13374-82. Gäbele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW, Brenner DA, Rippe RA. PMID: 15677443.
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    283. Clinical syndromes of alcoholic liver disease. Dig Dis. 2005; 23(3-4):255-63. Adachi M, Brenner DA. PMID: 16508290.
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    284. Molecular mechanisms of alcohol-induced hepatic fibrosis. Dig Dis. 2005; 23(3-4):264-74. Siegmund SV, Dooley S, Brenner DA. PMID: 16508291.
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    285. Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. Gut. 2005 Jan; 54(1):134-41. Sanz S, Pucilowska JB, Liu S, Rodríguez-Ortigosa CM, Lund PK, Brenner DA, Fuller CR, Simmons JG, Pardo A, Martínez-Chantar ML, Fagin JA, Prieto J. PMID: 15591519; PMCID: PMC1774353.
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    286. Data from arrays: an embarrassment of riches. Gastroenterology. 2004 Dec; 127(6):1659. Brenner DA. PMID: 15578500.
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    287. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Hepatology. 2004 Nov; 40(5):1151-9. Magness ST, Bataller R, Yang L, Brenner DA. PMID: 15389867.
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    288. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Hepatology. 2004 Nov; 40(5):1106-15. Parsons CJ, Bradford BU, Pan CQ, Cheung E, Schauer M, Knorr A, Krebs B, Kraft S, Zahn S, Brocks B, Feirt N, Mei B, Cho MS, Ramamoorthi R, Roldan G, Ng P, Lum P, Hirth-Dietrich C, Tomkinson A, Brenner DA. PMID: 15389776.
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    289. From quiescence to activation: Gene regulation in hepatic stellate cells. Gastroenterology. 2004 Oct; 127(4):1260-2. Rippe RA, Brenner DA. PMID: 15481004.
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    290. Akt activation protects rat liver from ischemia/reperfusion injury. J Surg Res. 2004 Oct; 121(2):159-70. Harada N, Hatano E, Koizumi N, Nitta T, Yoshida M, Yamamoto N, Brenner DA, Yamaoka Y. PMID: 15501455.
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    291. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Transplantation. 2004 Aug 15; 78(3):324-32. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R, Brenner DA, Lemasters J. PMID: 15316358.
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    292. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. J Immunol. 2004 Aug 01; 173(3):1561-70. Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE, Brenner DA, Jobin C. PMID: 15265883.
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    293. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. J Hepatol. 2004 Jun; 40(6):942-51. Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ, Brenner DA, Rippe RA, Behrns KE. PMID: 15158334.
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    294. TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein. Surgery. 2004 Jun; 135(6):619-28. Black D, Bird MA, Hayden M, Schrum LW, Lange P, Samson C, Hatano E, Rippe RA, Brenner DA, Behrns KE. PMID: 15179368.
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    295. Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region. J Biol Chem. 2004 May 28; 279(22):23822-9. Lindquist JN, Parsons CJ, Stefanovic B, Brenner DA. PMID: 14973140.
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    296. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. FASEB J. 2004 Apr; 18(6):720-2. Schwabe RF, Uchinami H, Qian T, Bennett BL, Lemasters JJ, Brenner DA. PMID: 14766793.
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    297. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology. 2004 Feb; 126(2):529-40. Bataller R, Paik YH, Lindquist JN, Lemasters JJ, Brenner DA. PMID: 14762790.
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    298. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Mol Cell Biol. 2004 Feb; 24(4):1758-68. Stefanovic B, Stefanovic L, Schnabl B, Bataller R, Brenner DA. PMID: 14749390; PMCID: PMC344171.
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    299. Gastrointestinal basic science 2002-2003: the year in review. Clin Gastroenterol Hepatol. 2004 Jan; 2(1):9-13. Brenner DA. PMID: 15017626.
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    300. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest. 2003 Nov; 112(9):1383-94. Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ, Brenner DA. PMID: 14597764; PMCID: PMC228420.
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    301. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. Liver Int. 2003 Oct; 23(5):386-96. Imose M, Nagaki M, Naiki T, Osawa Y, Brenner DA, Asano T, Hayashi H, Kato T, Moriwaki H. PMID: 14708901.
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    302. MELD and the practicing gastroenterologist. Gastroenterology. 2003 Oct; 125(4):1009. Brown RS, Brenner DA. PMID: 14517781.
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    303. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. Transplantation. 2003 Jul 15; 76(1):28-37. Lehmann TG, Wheeler MD, Froh M, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ, Brenner DA, Thurman RG. PMID: 12865782.
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    304. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. J Hepatol. 2003 Jul; 39(1):38-46. Kweon YO, Paik YH, Schnabl B, Qian T, Lemasters JJ, Brenner DA. PMID: 12821042.
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    305. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. Am J Physiol Gastrointest Liver Physiol. 2003 Nov; 285(5):G949-58. Schwabe RF, Bataller R, Brenner DA. PMID: 12829440.
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    306. Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver. Am J Physiol Gastrointest Liver Physiol. 2003 Sep; 285(3):G642-51. Bataller R, Gäbele E, Schoonhoven R, Morris T, Lehnert M, Yang L, Brenner DA, Rippe RA. PMID: 12773299.
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    307. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology. 2003 May; 37(5):1043-55. Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C, Brenner DA. PMID: 12717385.
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    308. Expression of the NF-kappa B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activation. J Immunol. 2003 Apr 15; 170(8):4053-60. Osawa Y, Nagaki M, Banno Y, Brenner DA, Nozawa Y, Moriwaki H, Nakashima S. PMID: 12682234.
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    309. Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition. Toxicol Sci. 2003 May; 73(1):44-52. Oh KW, Qian T, Brenner DA, Lemasters JJ. PMID: 12700412.
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    310. Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. J Hepatol. 2003 Apr; 38(4):468-75. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T, Brenner DA, Yamaoka Y. PMID: 12663239.
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    311. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology. 2003 Apr; 37(4):824-32. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R, Brenner DA. PMID: 12668975.
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    312. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Hepatology. 2003 Apr; 37(4):833-41. Luedde T, Rodriguez ME, Tacke F, Xiong Y, Brenner DA, Trautwein C. PMID: 12668976.
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    313. Hepatitis C and alcohol: fundamental and translational research directions. Alcohol Clin Exp Res. 2003 Apr; 27(4):726-31. Morgan TR, Brenner D, Everhart J, French SW, Fried MW, Gretch DR, Koziel MJ, McClain CJ, Peters MG, Weinman SA, Lucas DL. PMID: 12711937.
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    314. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. Hepatology. 2003 Mar; 37(3):653-64. Schnabl B, Purbeck CA, Choi YH, Hagedorn CH, Brenner D. PMID: 12601363.
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    315. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. Hepatology. 2003 Mar; 37(3):493-503. Bataller R, North KE, Brenner DA. PMID: 12601343.
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    316. Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat. Gastroenterology. 2003 Feb; 124(2):445-58. Iimuro Y, Nishio T, Morimoto T, Nitta T, Stefanovic B, Choi SK, Brenner DA, Yamaoka Y. PMID: 12557150.
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    317. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Hepatology. 2003 Feb; 37(2):267-76. Yata Y, Scanga A, Gillan A, Yang L, Reif S, Breindl M, Brenner DA, Rippe RA. PMID: 12540776.
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    318. The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression. J Biol Chem. 2003 Mar 07; 278(10):8083-90. Reif S, Lang A, Lindquist JN, Yata Y, Gabele E, Scanga A, Brenner DA, Rippe RA. PMID: 12502711.
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    319. Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. Antioxid Redox Signal. 2002 Oct; 4(5):769-81. Lemasters JJ, Qian T, He L, Kim JS, Elmore SP, Cascio WE, Brenner DA. PMID: 12470504.
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    320. An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. Blood. 2002 Aug 15; 100(4):1470-7. Magness ST, Maeda N, Brenner DA. PMID: 12149233.
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    321. Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. Hepatology. 2002 Aug; 36(2):315-25. Liedtke C, Plümpe J, Kubicka S, Bradham CA, Manns MP, Brenner DA, Trautwein C. PMID: 12143039.
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    322. Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy. J Biol Chem. 2002 May 17; 277(20):18229-37. Stefanovic B, Schnabl B, Brenner DA. PMID: 11889120.
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    323. Immortal activated human hepatic stellate cells generated by ectopic telomerase expression. Lab Invest. 2002 Mar; 82(3):323-33. Schnabl B, Choi YH, Olsen JC, Hagedorn CH, Brenner DA. PMID: 11896211.
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    324. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. Am J Physiol Gastrointest Liver Physiol. 2001 Dec; 281(6):G1357-68. Hatano E, Brenner DA. PMID: 11705740.
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    325. Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B. J Hepatol. 2001 Dec; 35(6):749-55. Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, Schoonhoven R, Brenner DA, Fried MW, Burkhardt E. PMID: 11738102.
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    326. Exercise training attenuates age-associated diastolic dysfunction in rats. Circulation. 2001 Jul 10; 104(2):221-6. Brenner DA, Apstein CS, Saupe KW. PMID: 11447090.
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    327. TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. J Immunol. 2001 Jul 01; 167(1):173-80. Osawa Y, Banno Y, Nagaki M, Brenner DA, Naiki T, Nozawa Y, Nakashima S, Moriwaki H. PMID: 11418646.
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    328. The role of Smad3 in mediating mouse hepatic stellate cell activation. Hepatology. 2001 Jul; 34(1):89-100. Schnabl B, Kweon YO, Frederick JP, Wang XF, Rippe RA, Brenner DA. PMID: 11431738.
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    329. CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. J Immunol. 2001 Jun 01; 166(11):6812-9. Schwabe RF, Schnabl B, Kweon YO, Brenner DA. PMID: 11359840.
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    330. Development of an animal model of chronic alcohol-induced pancreatitis in the rat. Am J Physiol Gastrointest Liver Physiol. 2001 Jun; 280(6):G1178-86. Kono H, Nakagami M, Rusyn I, Connor HD, Stefanovic B, Brenner DA, Mason RP, Arteel GE, Thurman RG. PMID: 11352811.
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    331. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. Circulation. 2001 Apr 10; 103(14):1920-7. Jain M, DerSimonian H, Brenner DA, Ngoy S, Teller P, Edge AS, Zawadzka A, Wetzel K, Sawyer DB, Colucci WS, Apstein CS, Liao R. PMID: 11294813.
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    332. NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis. Gastroenterology. 2001 Apr; 120(5):1251-62. Hatano E, Bennett BL, Manning AM, Qian T, Lemasters JJ, Brenner DA. PMID: 11266388.
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    333. Techniques to measure nucleic acid-protein binding and specificity. Nuclear extract preparations, DNase I footprinting, and mobility shift assays. Methods Mol Biol. 2001; 160:459-79. Rippe RA, Brenner DA, Tugores A. PMID: 11265303.
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    334. Autocrine expression of activated transforming growth factor-beta(1) induces apoptosis in normal rat liver. Am J Physiol Gastrointest Liver Physiol. 2001 Jan; 280(1):G139-48. Schrum LW, Bird MA, Salcher O, Burchardt ER, Grisham JW, Brenner DA, Rippe RA, Behrns KE. PMID: 11123207.
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    335. Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes. Hepatology. 2001 Jan; 33(1):81-90. Schwabe RF, Bennett BL, Manning AM, Brenner DA. PMID: 11124824.
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    336. Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat. Hepatology. 2000 Dec; 32(6):1255-64. Lehmann TG, Wheeler MD, Schwabe RF, Connor HD, Schoonhoven R, Bunzendahl H, Brenner DA, Jude Samulski R, Zhong Z, Thurman RG. PMID: 11093732.
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    337. Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB. Hepatology. 2000 Dec; 32(6):1272-9. Nagaki M, Naiki T, Brenner DA, Osawa Y, Imose M, Hayashi H, Banno Y, Nakashima S, Moriwaki H. PMID: 11093734.
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    338. Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation. Am J Physiol Gastrointest Liver Physiol. 2000 Dec; 279(6):G1333-42. Lang A, Schrum LW, Schoonhoven R, Tuvia S, Solís-Herruzo JA, Tsukamoto H, Brenner DA, Rippe RA. PMID: 11093957.
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    339. Moderate alcohol drinking: effects on the heart and liver. Gastroenterology. 2000 Nov; 119(5):1399-401. Brenner DA. PMID: 11054400.
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    340. Characterization of the interaction between alphaCP(2) and the 3'-untranslated region of collagen alpha1(I) mRNA. Nucleic Acids Res. 2000 Nov 01; 28(21):4306-16. Lindquist JN, Kauschke SG, Stefanovic B, Burchardt ER, Brenner DA. PMID: 11058131; PMCID: PMC113122.
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    341. The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways. J Biol Chem. 2000 Sep 29; 275(39):30597-604. Xu LH, Yang X, Bradham CA, Brenner DA, Baldwin AS, Craven RJ, Cance WG. PMID: 10899173.
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    342. Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. Gastroenterology. 2000 Aug; 119(2):446-60. Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U, Brenner D, Manns M, Trautwein C. PMID: 10930380.
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    343. Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. J Hepatol. 2000 Jul; 33(1):49-58. Lang A, Schoonhoven R, Tuvia S, Brenner DA, Rippe RA. PMID: 10905586.
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    344. Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver. Am J Physiol Gastrointest Liver Physiol. 2000 Jul; 279(1):G100-6. Enomoto N, Ikejima K, Yamashina S, Enomoto A, Nishiura T, Nishimura T, Brenner DA, Schemmer P, Bradford BU, Rivera CA, Zhong Z, Thurman RG. PMID: 10898751.
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    345. Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells. Blood. 2000 Jun 01; 95(11):3568-77. Magness ST, Tugores A, Brenner DA. PMID: 10828045.
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    346. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes. J Biol Chem. 2000 Apr 21; 275(16):11814-23. Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ, Brenner DA. PMID: 10766806.
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    347. Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells. J Biol Chem. 2000 Apr 21; 275(16):12207-13. Böcker U, Schottelius A, Watson JM, Holt L, Licato LL, Brenner DA, Sartor RB, Jobin C. PMID: 10766857.
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    348. Gene expression and cytokine and enzyme activation in the liver after a burn injury. J Burn Care Rehabil. 2000 Mar-Apr; 21(2):135-41. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T, Brenner DA, Meyer AA. PMID: 10752746.
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    349. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. J Gastroenterol Hepatol. 2000 Mar; 15 Suppl:D20-5. Enomoto N, Ikejima K, Bradford BU, Rivera CA, Kono H, Goto M, Yamashina S, Schemmer P, Kitamura T, Oide H, Takei Y, Hirose M, Shimizu H, Miyazaki A, Brenner DA, Sato N, Thurman RG. PMID: 10759216.
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    350. c-Jun does not mediate hepatocyte apoptosis following NFkappaB inhibition and partial hepatectomy. J Surg Res. 2000 Feb; 88(2):142-9. Schrum LW, Black D, Iimuro Y, Rippe RA, Brenner DA, Behrns KE. PMID: 10644480.
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    351. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. Hepatology. 2000 Feb; 31(2):391-8. Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W, Forman D, Brenner D, Thurman RG. PMID: 10655262.
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    352. The 5' stem-loop regulates expression of collagen alpha1(I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix. Nucleic Acids Res. 2000 Jan 15; 28(2):641-7. Stefanovic B, Lindquist J, Brenner DA. PMID: 10606666; PMCID: PMC102518.
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    353. Impact of burn injury on hepatic TGF-beta1 expression and plasma TGF-beta1 levels. J Trauma. 2000 Jan; 48(1):39-44. Nishimura T, Nishiura T, deSerres S, Nakagawa T, Brenner DA, Meyer AA. PMID: 10647563.
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    354. Regulation of collagen alpha1(I) expression in hepatic stellate cells. J Gastroenterol. 2000; 35 Suppl 12:80-3. Lindquist JN, Stefanovic B, Brenner DA. PMID: 10779224.
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    355. New aspects of hepatic fibrosis. J Hepatol. 2000; 32(1 Suppl):32-8. Brenner DA, Waterboer T, Choi SK, Lindquist JN, Stefanovic B, Burchardt E, Yamauchi M, Gillan A, Rippe RA. PMID: 10728792.
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    356. Glutamine metabolism stimulates intestinal cell MAPKs by a cAMP-inhibitable, Raf-independent mechanism. Gastroenterology. 2000 Jan; 118(1):90-100. Rhoads JM, Argenzio RA, Chen W, Graves LM, Licato LL, Blikslager AT, Smith J, Gatzy J, Brenner DA. PMID: 10611157.
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    357. Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms. Carcinogenesis. 1999 Nov; 20(11):2095-100. Rusyn I, Bradham CA, Cohn L, Schoonhoven R, Swenberg JA, Brenner DA, Thurman RG. PMID: 10545411.
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    358. Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. J Biol Chem. 1999 Oct 22; 274(43):30919-26. Solís-Herruzo JA, Rippe RA, Schrum LW, de La Torre P, García I, Jeffrey JJ, Muñoz-Yagüe T, Brenner DA. PMID: 10521486.
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    359. NF-kappaB inhibits expression of the alpha1(I) collagen gene. DNA Cell Biol. 1999 Oct; 18(10):751-61. Rippe RA, Schrum LW, Stefanovic B, Solís-Herruzo JA, Brenner DA. PMID: 10541434.
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    360. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. J Immunol. 1999 Sep 15; 163(6):3474-83. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS, Brenner DA, Sartor RB. PMID: 10477620.
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    361. Estriol sensitizes rat Kupffer cells via gut-derived endotoxin. Am J Physiol. 1999 09; 277(3):G671-7. Enomoto N, Yamashina S, Schemmer P, Rivera CA, Bradford BU, Enomoto A, Brenner DA, Thurman RG. PMID: 10484393.
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    362. IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. Am J Respir Cell Mol Biol. 1999 Aug; 21(2):238-45. Batra RK, Guttridge DC, Brenner DA, Dubinett SM, Baldwin AS, Boucher RC. PMID: 10423407.
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    363. Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro. J Bone Miner Res. 1999 Aug; 14(8):1272-80. Uzawa K, Grzesik WJ, Nishiura T, Kuznetsov SA, Robey PG, Brenner DA, Yamauchi M. PMID: 10457259.
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    364. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. J Bioenerg Biomembr. 1999 Aug; 31(4):305-19. Lemasters JJ, Qian T, Bradham CA, Brenner DA, Cascio WE, Trost LC, Nishimura Y, Nieminen AL, Herman B. PMID: 10665521.
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    365. Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells. Liver Transpl Surg. 1999 Jul; 5(4):282-93. Bradham CA, Schemmer P, Stachlewitz RF, Thurman RG, Brenner DA. PMID: 10388501.
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    366. Regulatory role of the conserved stem-loop structure at the 5' end of collagen alpha1(I) mRNA. Mol Cell Biol. 1999 Jun; 19(6):4334-42. Stefanovic B, Hellerbrand C, Brenner DA. PMID: 10330174; PMCID: PMC104393.
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    367. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. Hepatology. 1999 Jun; 29(6):1680-9. Enomoto N, Yamashina S, Kono H, Schemmer P, Rivera CA, Enomoto A, Nishiura T, Nishimura T, Brenner DA, Thurman RG. PMID: 10347108.
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    368. TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells. J Immunol. 1999 Apr 15; 162(8):4447-54. Jobin C, Holt L, Bradham CA, Streetz K, Brenner DA, Sartor RB. PMID: 10201981.
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    369. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. Am J Physiol. 1999 03; 276(3):G591-8. Ikejima K, Enomoto N, Seabra V, Ikejima A, Brenner DA, Thurman RG. PMID: 10070034.
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    370. Gene regulation in hepatic stellate cell. Ital J Gastroenterol Hepatol. 1999 Mar; 31(2):173-9. Lang A, Brenner DA. PMID: 10363203.
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    371. Molecular and cellular biology of the small intestine. Curr Opin Gastroenterol. 1999 Mar; 15(2):103-7. Jobin C, Behrns KE, Brenner DA. PMID: 17023928.
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    372. Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion. Biochim Biophys Acta. 1999 Jan 06; 1453(1):161-74. Magness ST, Brenner DA. PMID: 9989256.
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    373. Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice. Gene Expr. 1999; 8(3):151-63. Krempen K, Grotkopp D, Hall K, Bache A, Gillan A, Rippe RA, Brenner DA, Breindl M. PMID: 10634317; PMCID: PMC6157370.
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    374. Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death. Biochem Soc Symp. 1999; 66:205-22. Lemasters JJ, Qian T, Trost LC, Herman B, Cascio WE, Bradham CA, Brenner DA, Nieminen AL. PMID: 10989668.
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    375. The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo. J Hepatol. 1999 Jan; 30(1):77-87. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER, Brenner DA. PMID: 9927153.
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    376. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release. Mol Cell Biol. 1998 Nov; 18(11):6353-64. Bradham CA, Qian T, Streetz K, Trautwein C, Brenner DA, Lemasters JJ. PMID: 9774651; PMCID: PMC109221.
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    377. NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis. Am J Physiol. 1998 10; 275(4):C1058-66. Xu Y, Bialik S, Jones BE, Iimuro Y, Kitsis RN, Srinivasan A, Brenner DA, Czaja MJ. PMID: 9755059.
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    378. Porphyrias. J Clin Gastroenterol. 1998 Oct; 27(3):192-8. Scarlett YV, Brenner DA. PMID: 9802444.
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    379. Mechanisms of hepatic toxicity. I. TNF-induced liver injury. Am J Physiol. 1998 09; 275(3):G387-92. Bradham CA, Plümpe J, Manns MP, Brenner DA, Trautwein C. PMID: 9724248.
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    380. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. J Gastroenterol Hepatol. 1998 Sep; 13 Suppl:S39-50. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, Connor HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT, Brenner D, Kadiiska M, Mason RP. PMID: 9792033.
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    381. Signal transduction during liver regeneration. J Gastroenterol Hepatol. 1998 Sep; 13 Suppl:S93-5. Brenner DA. PMID: 9792040.
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    382. Signal transduction during liver regeneration. J Gastroenterol Hepatol. 1998 Sep; 13(S1):S93-S95. Brenner DA. PMID: 28976689.
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    383. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. J Gastroenterol Hepatol. 1998 Sep; 13(S1):S39-S50. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, Connor HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT, Brenner D, Kadiiska M, Mason RP. PMID: 28976690.
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    384. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta. 1998 Aug 10; 1366(1-2):177-96. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA, Brenner DA, Herman B. PMID: 9714796.
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    385. Cytokines induce NF-kappaB in activated but not in quiescent rat hepatic stellate cells. Am J Physiol. 1998 08; 275(2):G269-78. Hellerbrand C, Jobin C, Licato LL, Sartor RB, Brenner DA. PMID: 9688654.
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    386. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. Gastroenterology. 1998 Aug; 115(2):443-51. Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H, Brenner DA, Thurman RG. PMID: 9679050.
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    387. Analysis of signaling protein kinases in human colon or colorectal carcinomas. Dig Dis Sci. 1998 Jul; 43(7):1454-64. Licato LL, Brenner DA. PMID: 9690379.
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    388. Analysis of the human ferrochelatase promoter in transgenic mice. Blood. 1998 Jul 01; 92(1):320-8. Magness ST, Tugores A, Diala ES, Brenner DA. PMID: 9639532.
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    389. Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation. J Clin Invest. 1998 Jul 01; 102(1):107-14. Bloomer J, Bruzzone C, Zhu L, Scarlett Y, Magness S, Brenner D. PMID: 9649563; PMCID: PMC509071.
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    390. Mediation by NF-kappa B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors. Gut. 1998 Jun; 42(6):779-87. Jobin C, Hellerbrand C, Licato LL, Brenner DA, Sartor RB. PMID: 9691914; PMCID: PMC1727151.
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    391. Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. Gastroenterology. 1998 May; 114(5):1035-45. Trautwein C, Rakemann T, Brenner DA, Streetz K, Licato L, Manns MP, Tiegs G. PMID: 9558294.
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    392. Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor. Hepatology. 1998 May; 27(5):1285-95. Hellerbrand C, Jobin C, Iimuro Y, Licato L, Sartor RB, Brenner DA. PMID: 9581682.
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    393. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. Am J Physiol. 1998 04; 274(4):G669-76. Ikejima K, Enomoto N, Iimuro Y, Ikejima A, Fang D, Xu J, Forman DT, Brenner DA, Thurman RG. PMID: 9575848.
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    394. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. J Clin Invest. 1998 Feb 15; 101(4):802-11. Iimuro Y, Nishiura T, Hellerbrand C, Behrns KE, Schoonhoven R, Grisham JW, Brenner DA. PMID: 9466975; PMCID: PMC508628.
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    395. Hepatic porphyrias. Clin Liver Dis. 1998 Feb; 2(1):77-102, vi. Scarlett YV, Brenner DA, Bloomer JR. PMID: 15560047.
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    396. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells. J Immunol. 1998 Jan 01; 160(1):410-8. Jobin C, Panja A, Hellerbrand C, Iimuro Y, Didonato J, Brenner DA, Sartor RB. PMID: 9551998.
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    397. Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy. Biofactors. 1998; 8(3-4):283-5. Lemasters JJ, Qian T, Elmore SP, Trost LC, Nishimura Y, Herman B, Bradham CA, Brenner DA, Nieminen AL. PMID: 9914830.
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    398. In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia. Gastroenterology. 1997 Nov; 113(5):1589-98. Licato LL, Keku TO, Wurzelmann JI, Murray SC, Woosley JT, Sandler RS, Brenner DA. PMID: 9352861.
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    399. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. Am J Physiol. 1997 10; 273(4):G795-803. Xu Y, Bradham C, Brenner DA, Czaja MJ. PMID: 9357820.
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    400. Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cells. Mol Cell Biol. 1997 Sep; 17(9):5201-9. Stefanovic B, Hellerbrand C, Holcik M, Briendl M, Aliebhaber S, Brenner DA. PMID: 9271398; PMCID: PMC232371.
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    401. L-glutamine stimulates intestinal cell proliferation and activates mitogen-activated protein kinases. Am J Physiol. 1997 May; 272(5 Pt 1):G943-53. Rhoads JM, Argenzio RA, Chen W, Rippe RA, Westwick JK, Cox AD, Berschneider HM, Brenner DA. PMID: 9176200.
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    402. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Hepatology. 1997 May; 25(5):1128-35. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG, Brenner DA. PMID: 9141429.
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    403. Binding of upstream stimulatory factor to an E-box in the 3'-flanking region stimulates alpha1(I) collagen gene transcription. J Biol Chem. 1997 Jan 17; 272(3):1753-60. Rippe RA, Umezawa A, Kimball JP, Breindl M, Brenner DA. PMID: 8999857.
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    404. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. J Clin Invest. 1996 Dec 15; 98(12):2771-8. Mallat A, Préaux AM, Serradeil-Le Gal C, Raufaste D, Gallois C, Brenner DA, Bradham C, Maclouf J, Iourgenko V, Fouassier L, Dhumeaux D, Mavier P, Lotersztajn S. PMID: 8981923; PMCID: PMC507742.
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    405. Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo. Am J Physiol. 1996 Nov; 271(5 Pt 1):G780-90. Westwick JK, Fleckenstein J, Yin M, Yang SQ, Bradham CA, Brenner DA, Diehl AM. PMID: 8944691.
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    406. Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. Hepatology. 1996 Sep; 24(3):670-6. Wang SC, Tsukamoto H, Brenner DA, Rippe RA. PMID: 8781341.
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    407. Detection of alpha-hydroxyethyl free radical adducts in the pancreas after chronic exposure to alcohol in the rat. Mol Pharmacol. 1996 Sep; 50(3):656-61. Iimuro Y, Bradford BU, Gao W, Kadiiska M, Mason RP, Stefanovic B, Brenner DA, Thurman RG. PMID: 8794907.
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    408. New functions for the aryl hydrocarbon receptor. Hepatology. 1996 Feb; 23(2):379-80. Brenner DA. PMID: 8591868.
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    409. Ferrochelatase cDNA delivered by adenoviral vector corrects biochemical defect in protoporphyric cells. Hum Gene Ther. 1995 Oct; 6(10):1285-90. Magness ST, Brenner DA. PMID: 8590732.
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    410. L-glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line. Am J Physiol. 1995 Oct; 269(4 Pt 1):G591-9. Kandil HM, Argenzio RA, Chen W, Berschneider HM, Stiles AD, Westwick JK, Rippe RA, Brenner DA, Rhoads JM. PMID: 7485512.
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    411. Ceramide activates the stress-activated protein kinases. J Biol Chem. 1995 Sep 29; 270(39):22689-92. Westwick JK, Bielawska AE, Dbaibo G, Hannun YA, Brenner DA. PMID: 7559390.
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    412. Insulin-like growth factor-I and epidermal growth factor interact to regulate growth and gene expression in IEC-6 intestinal epithelial cells. Mol Endocrinol. 1995 Sep; 9(9):1157-65. Simmons JG, Hoyt EC, Westwick JK, Brenner DA, Pucilowska JB, Lund PK. PMID: 7491108.
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    413. Sp1 binding activity increases in activated Ito cells. Hepatology. 1995 Jul; 22(1):241-51. Rippe RA, Almounajed G, Brenner DA. PMID: 7601417.
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    414. Current and prospective therapies for hepatic fibrosis. Compr Ther. 1995 Jun; 21(6):303-7. Trotter JF, Brenner DA. PMID: 7664542.
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    415. Activation of Jun kinase is an early event in hepatic regeneration. J Clin Invest. 1995 Feb; 95(2):803-10. Westwick JK, Weitzel C, Leffert HL, Brenner DA. PMID: 7860764; PMCID: PMC295558.
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    416. Methods for analyzing c-Jun kinase. Methods Enzymol. 1995; 255:342-59. Westwick JK, Brenner DA. PMID: 8524120.
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    417. Post-transcriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells. Nucleic Acids Symp Ser. 1995; (33):212-4. Stefanovic B, Hellerbrand C, Brenner DA. PMID: 8643373.
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    418. A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene. J Biol Chem. 1994 Dec 09; 269(49):30789-97. Tugores A, Magness ST, Brenner DA. PMID: 7983009.
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    419. Fibrogenesis and type I collagen gene regulation. J Lab Clin Med. 1994 Dec; 124(6):755-60. Brenner DA, Rippe RA, Rhodes K, Trotter JF, Breindl M. PMID: 7798786.
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    420. Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. J Biol Chem. 1994 Oct 21; 269(42):26396-401. Westwick JK, Weitzel C, Minden A, Karin M, Brenner DA. PMID: 7929360.
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    421. Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. Am J Physiol. 1994 Oct; 267(4 Pt 1):G552-61. Diehl AM, Yin M, Fleckenstein J, Yang SQ, Lin HZ, Brenner DA, Westwick J, Bagby G, Nelson S. PMID: 7943321.
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    422. A method for in vitro DNase I footprinting analysis on supercoiled templates. Biotechniques. 1994 Sep; 17(3):410-2. Tugores A, Brenner DA. PMID: 7818885.
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    423. DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism. Mol Cell Biol. 1994 Sep; 14(9):5950-60. Rhodes K, Rippe RA, Umezawa A, Nehls M, Brenner DA, Breindl M. PMID: 8065328; PMCID: PMC359121.
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    424. Deletion of the ferrochelatase gene in a patient with protoporphyria. Hum Mol Genet. 1994 Sep; 3(9):1695-7. Magness ST, Tugores A, Christensen SR, Wagner-Mcpherson C, Evans GA, Naylor EW, Brenner DA. PMID: 7833934.
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    425. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. J Biol Chem. 1994 Jul 29; 269(30):19203-6. Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD, Brenner DA, Der CJ. PMID: 8034681.
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    426. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. Proc Natl Acad Sci U S A. 1994 Jun 21; 91(13):6030-4. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M, Karin M, Brenner DA. PMID: 8016110; PMCID: PMC44131.
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    427. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. J Clin Invest. 1993 Dec; 92(6):2916-21. Nehls MC, Brenner DA, Gruss HJ, Dierbach H, Mertelsmann R, Herrmann F. PMID: 7504695; PMCID: PMC288495.
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    428. Identification of c-fos-responsive elements downstream of TAR in the long terminal repeat of human immunodeficiency virus type-1. J Clin Invest. 1993 Sep; 92(3):1336-48. Roebuck KA, Brenner DA, Kagnoff MF. PMID: 8376588; PMCID: PMC288275.
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    429. Inactivation of plasmid reporter gene expression by one benzo(a)pyrene diol-epoxide DNA adduct in adult rat hepatocytes. Cancer Res. 1993 May 15; 53(10 Suppl):2279-86. Koch KS, Fletcher RG, Grond MP, Inyang AI, Lu XP, Brenner DA, Leffert HL. PMID: 8485714.
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    430. Type I collagen gene regulation and the molecular pathogenesis of cirrhosis. Am J Physiol. 1993 Apr; 264(4 Pt 1):G589-95. Brenner DA, Westwick J, Breindl M. PMID: 8476045.
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    431. Stimulation of the collagen alpha 1 (I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis. Hepatology. 1993 Feb; 17(2):287-92. Brenner DA, Veloz L, Jaenisch R, Alcorn JM. PMID: 8428727.
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    432. Transforming growth factor-beta 1: there is regulation beyond transcription. Hepatology. 1993 Jan; 17(1):164-6. Brenner DA. PMID: 8423038.
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    433. Activation of activating protein 1 during hepatic acute phase response. Am J Physiol. 1993 Jan; 264(1 Pt 1):G95-103. Hattori M, Tugores A, Westwick JK, Veloz L, Leffert HL, Karin M, Brenner DA. PMID: 8430810.
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    434. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Cell. 1992 Sep 04; 70(5):777-89. Lin A, Frost J, Deng T, Smeal T, al-Alawi N, Kikkawa U, Hunter T, Brenner D, Karin M. PMID: 1516134.
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    435. NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene expression. DNA Cell Biol. 1992 Jul-Aug; 11(6):443-52. Nehls MC, Grapilon ML, Brenner DA. PMID: 1524678.
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    436. A molecular defect in human protoporphyria. Am J Hum Genet. 1992 Jun; 50(6):1203-10. Brenner DA, Didier JM, Frasier F, Christensen SR, Evans GA, Dailey HA. PMID: 1376018; PMCID: PMC1682545.
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    437. A logical approach to the patient with jaundice. Contemp Intern Med. 1992 May; 4(5):43-58. Lyche KD, Brenner DA. PMID: 10171614.
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    438. Differential expression of the transfected liver-specific alpha 1-inhibitor III gene in normal hepatocytes and hepatoma cells in culture. Biochem Biophys Res Commun. 1992 Feb 28; 183(1):184-92. Koch KS, Lu XP, Brenner DA, Leffert HL. PMID: 1543489.
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    439. Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation. Am J Clin Nutr. 1991 12; 54(6 Suppl):1141S-1143S. Houglum KP, Brenner DA, Chojkier M. PMID: 1962560.
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    440. Transforming growth factor B and hepatic fibrosis: cause or effect? Hepatology. 1991 Oct; 14(4 Pt 1):740-2. Brenner DA. PMID: 1916680.
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    441. Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter. Mol Cell Biol. 1991 Aug; 11(8):4065-73. Nehls MC, Rippe RA, Veloz L, Brenner DA. PMID: 2072909; PMCID: PMC361214.
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    442. d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. Modulation of constitutive collagen gene expression by lipid peroxidation. J Clin Invest. 1991 Jun; 87(6):2230-5. Houglum K, Brenner DA, Chojkier M. PMID: 2040703; PMCID: PMC296984.
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    443. HIV-1 infection and expression in human colonic cells: infection and expression in CD4+ and CD4- cell lines. AIDS. 1991 Mar; 5(3):275-81. Omary MB, Brenner DA, de Grandpre LY, Roebuck KA, Richman DD, Kagnoff MF. PMID: 2059367.
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    444. Cloning of murine ferrochelatase. Proc Natl Acad Sci U S A. 1991 Feb 01; 88(3):849-53. Brenner DA, Frasier F. PMID: 1704134; PMCID: PMC50911.
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    445. Expression of human immunodeficiency virus-1 in human colonic cells. Immunol Res. 1991; 10(3-4):452-5. Kagnoff MF, Omary MB, de Grandpre LY, Roebuck KA, Richman DD, Brenner DA. PMID: 1955772.
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    446. A simplified method for the preparation of transcriptionally active liver nuclear extracts. DNA Cell Biol. 1990 Dec; 9(10):777-81. Hattori M, Tugores A, Veloz L, Karin M, Brenner DA. PMID: 2264931.
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    447. Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels. Arch Biochem Biophys. 1990 Dec; 283(2):447-57. Stearns NA, Dong JM, Pan JX, Brenner DA, Sahagian GG. PMID: 2275556.
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    448. Mitogens and hepatocyte growth control in vivo and in vitro. In Vitro Cell Dev Biol. 1990 Nov; 26(11):1011-23. Koch KS, Lu XP, Brenner DA, Fey GH, Martinez-Conde A, Leffert HL. PMID: 2276991.
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