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    David Brenner

    TitleVice Chancellor - Health Sciences
    SchoolUniversity of California, San Diego
    DepartmentSchool of Medicine
    Address9500 Gilman Drive #0602
    CA La Jolla 92093
    Phone858-534-1501
    vCardDownload vCard
      Other Positions
      TitleDean - School of Medicine


      Collapse Biography 
      Collapse Education and Training
      UC San DiegoFellowship1988Gastroenterology
      NIH/NIDDK, Bethesda, MDFellowship1986Genetics & Biochemistry
      Yale UniversityIntern & Residency1985Internal Medicine
      Yale UniversityMD1979Medicine
      Yale UniversityBS1975Biology

      Collapse Research 
      Collapse Research Activities and Funding
      Microbiome as Therapeutic Target in Alcoholic Hepatitis
      NIH/NIAAA U01AA021856Jun 1, 2013 - May 31, 2018
      Role: Principal Investigator
      The Role of Inflammation and Stroma in Digestive Cancer
      NIH U54CA126513Sep 30, 2006 - Sep 21, 2011
      Role: Co-Investigator
      Angiotensin II and NADPH Oxidase in Hepatic Fibrosis
      NIH/NIDDK R01DK072237Sep 15, 2005 - Jun 30, 2011
      Role: Principal Investigator
      Hepatic Stellate Cell Activation induced by Hepatitis C Virus
      NIH/NIAAA R01AA015055Sep 30, 2003 - Aug 31, 2009
      Role: Principal Investigator
      Cond. Acceptance Post-Bac. Prog. Scholarship Fund
      NIH/NIMHD S22MD000227Sep 30, 2002 - Sep 29, 2005
      Role: Principal Investigator
      Molecular Pathogenesis of Apoptosis in Liver Cells
      NIH P01DK059340Sep 21, 2001 - May 31, 2006
      Role: Co-Investigator
      ONCOGENIC K-RAS INDUCTION OF GASTRIN GENE TRANSCRIPTION
      NIH/NIDDK R01DK055686Aug 15, 2000 - Jul 31, 2006
      Role: Principal Investigator
      GENE TECHNOLOGY THERAPY AND ALCOHOL-INDUCED FIBROSIS
      NIH/NIAAA R01AA012586Sep 23, 1999 - Jun 30, 2003
      Role: Principal Investigator
      Southern California Research Center for ALPD and Cirrhosis
      NIH P50AA011999Jan 1, 1999 - Dec 31, 2018
      Role: Co-Investigator
      Molecular and Cellular Pathogenesis in Alcoholism
      NIH P60AA011605Dec 1, 1997 - Nov 30, 2017
      Role: Co-Investigator
      MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM
      NIH P50AA011605Dec 1, 1997 - Nov 30, 2002
      Role: Co-Investigator
      RAT MODEL OF ALCOHOLIC PANCREATITIS
      NIH/NIAAA R03AA011226Apr 1, 1997 - Mar 31, 1999
      Role: Principal Investigator
      Gastroenterology Research Training
      NIH/NIDDK T32DK007737Aug 1, 1996 - Jun 30, 2021
      Role: Principal Investigator
      GENE THERAPY FOR LIVER DISEASES
      NIH/NIDDK R13DK047627Jan 20, 1994 - Oct 31, 1994
      Role: Principal Investigator
      MOLECULAR DEFECTS IN PROTOPORPHYRIA
      NIH/NIDDK R01DK047361May 1, 1993 - May 31, 2004
      Role: Principal Investigator
      Integrated Center for InVivo Microscopy
      NIH P41RR005959Sep 1, 1990 - Jun 30, 2013
      Role: Co-Investigator
      FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS
      NIH/NCI P01CA050528Sep 8, 1989 - Jan 31, 1998
      Role: Co-Investigator
      Molecular Mechanisms by which TNFalpha Modulates Fibrosis
      NIH/NIGMS R01GM041804Apr 1, 1989 - Dec 31, 2014
      Role: Principal Investigator
      MOLECULAR DEFECT IN PROTOPORPHYRIA
      NIH/NIDDK R29DK039996Apr 1, 1988 - Mar 31, 1993
      Role: Principal Investigator
      General Clinical Research Center
      NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Brenner D. Thomas E. Starzl: Transplantation pioneer. Proc Natl Acad Sci U S A. 2017 Sep 11. PMID: 28893997.
        View in: PubMed
      2. Caussy C, Soni M, Cui J, Bettencourt R, Schork N, Chen CH, Ikhwan MA, Bassirian S, Cepin S, Gonzalez MP, Mendler M, Kono Y, Vodkin I, Mekeel K, Haldorson J, Hemming A, Andrews B, Salotti J, Richards L, Brenner D, Sirlin CB, Loomba R. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. J Clin Invest. 2017 Jun 30; 127(7):2697-2704. PMID: 28628033.
        View in: PubMed
      3. Reinders ME, Wardi G, Bettencourt R, Bouland D, Bazick J, Mendler M, Vodkin I, Kalmaz D, Savides T, Brenner D, Sell RE, Loomba R. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. Clin Gastroenterol Hepatol. 2017 Jun 07. PMID: 28602970.
        View in: PubMed
      4. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C, Bettencourt R, Highlander SK, Jones MB, Sirlin CB, Schnabl B, Brinkac L, Schork N, Chen CH, Brenner D, Biggs W, Yooseph S, Venter JC, Nelson KE. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Cell Metab. 2017 May 02; 25(5):1054-1062.e5. PMID: 28467925.
        View in: PubMed
      5. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K, Benner C, Heinz S, Bera T, Brenner D, Kisseleva T. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Invest. 2017 Apr 03; 127(4):1254-1270. PMID: 28287406.
        View in: PubMed
      6. Koyama Y, Brenner D. Liver inflammation and fibrosis. J Clin Invest. 2017 Jan 03; 127(1):55-64. PMID: 28045404.
        View in: PubMed
      7. Chapman MA, Mukund K, Subramaniam S, Brenner D, Lieber RL. Three distinct cell populations express extracellular matrix proteins and increase in number during skeletal muscle fibrosis. Am J Physiol Cell Physiol. 2017 Feb 01; 312(2):C131-C143. PMID: 27881411.
        View in: PubMed
      8. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA, Rizo E, Richards L, Brenner D, Sirlin CB, Loomba R. Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. Gastroenterology. 2017 Feb; 152(3):598-607.e2. PMID: 27911262.
        View in: PubMed
      9. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K, Richards L, Rizo E, Hernandez C, Kisseleva T, Schnabl B, Brenner D, Sirlin CB, Loomba R. Weight Loss Decreases Magnetic Resonance Elastography Estimated Liver Stiffness in Nonalcoholic Fatty Liver Disease. Clin Gastroenterol Hepatol. 2017 Mar; 15(3):463-464. PMID: 27712981.
        View in: PubMed
      10. Karin D, Koyama Y, Brenner D, Kisseleva T. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. Differentiation. 2016 Sep; 92(3):84-92. PMID: 27591095.
        View in: PubMed
      11. Kim IH, Xu J, Liu X, Koyama Y, Ma HY, Diggle K, You YH, Schilling JM, Jeste D, Sharma K, Brenner D, Kisseleva T. Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. Age (Dordr). 2016 Aug; 38(4):291-302. PMID: 27578257.
        View in: PubMed
      12. Cui J, Chen CH, Lo MT, Schork N, Bettencourt R, Gonzalez MP, Bhatt A, Hooker J, Shaffer K, Nelson KE, Long MT, Brenner D, Sirlin CB, Loomba R. Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study. Hepatology. 2016 Nov; 64(5):1547-1558. PMID: 27315352.
        View in: PubMed
      13. Koyama Y, Xu J, Liu X, Brenner D. New Developments on the Treatment of Liver Fibrosis. Dig Dis. 2016; 34(5):589-96. PMID: 27332862; PMCID: PMC4961096 [Available on 06/22/17].
      14. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R, Richards L, Salotti J, Bhatt A, Hooker J, Haufe W, Hooker C, Brenner D, Sirlin CB, Loomba R. Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial. J Hepatol. 2016 Aug; 65(2):369-76. PMID: 27151177.
        View in: PubMed
      15. Loomba R, Cui J, Wolfson T, Haufe W, Hooker J, Szeverenyi N, Ang B, Bhatt A, Wang K, Aryafar H, Behling C, Valasek MA, Lin GY, Gamst A, Brenner D, Yin M, Glaser KJ, Ehman RL, Sirlin CB. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. Am J Gastroenterol. 2016 Jul; 111(7):986-94. PMID: 27002798; PMCID: PMC5001170 [Available on 01/01/17].
      16. Ma HY, Xu J, Liu X, Zhu Y, Gao B, Karin M, Tsukamoto H, Jeste DV, Grant I, Roberts AJ, Contet C, Geoffroy C, Zheng B, Brenner D, Kisseleva T. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. PMID: 27239399.
        View in: PubMed
      17. Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH, Brenner D, Kisseleva T. Promising Therapy Candidates for Liver Fibrosis. Front Physiol. 2016; 7:47. PMID: 26909046; PMCID: PMC4754444.
      18. Liu X, Brenner D. Liver: DNA methylation controls liver fibrogenesis. Nat Rev Gastroenterol Hepatol. 2016 Mar; 13(3):126-8. PMID: 26860269.
        View in: PubMed
      19. Wang L, Fouts DE, Stärkel P, Hartmann P, Chen P, Llorente C, DePew J, Moncera K, Ho SB, Brenner D, Hooper LV, Schnabl B. Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. Cell Host Microbe. 2016 Feb 10; 19(2):227-39. PMID: 26867181; PMCID: PMC4786170 [Available on 02/10/17].
      20. Liang S, Kisseleva T, Brenner D. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Front Physiol. 2016; 7:17. PMID: 26869935; PMCID: PMC4735448.
      21. Schnabl B, Farshchi-Heydari S, Loomba R, Mattrey RF, Hoh CK, Sirlin CB, Brenner D, Behling CA, Vera DR. Staging of fibrosis in experimental non-alcoholic steatohepatitis by quantitative molecular imaging in rat models. Nucl Med Biol. 2016 Feb; 43(2):179-87. PMID: 26872443.
        View in: PubMed
      22. Brenner D, Paik YH, Schnabl B. Role of Gut Microbiota in Liver Disease. J Clin Gastroenterol. 2015 Nov-Dec; 49 Suppl 1:S25-7. PMID: 26447960; PMCID: PMC4602394 [Available on 11/01/16].
      23. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS, Brenner D, Qamar AA, Miloh TA, Guarino A, Guslandi M, Dieleman LA, Ringel Y, Quigley EM, Brandt LJ. Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion. J Clin Gastroenterol. 2015 Nov-Dec; 49 Suppl 1:S69-73. PMID: 26447969.
        View in: PubMed
      24. Loomba R, Schork N, Chen CH, Bettencourt R, Bhatt A, Ang B, Nguyen P, Hernandez C, Richards L, Salotti J, Lin S, Seki E, Nelson KE, Sirlin CB, Brenner D. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Gastroenterology. 2015 Dec; 149(7):1784-93. PMID: 26299412; PMCID: PMC4663110 [Available on 12/01/16].
      25. Lan T, Kisseleva T, Brenner D. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. PLoS One. 2015; 10(7):e0129743. PMID: 26222337; PMCID: PMC4519306.
      26. Koyama Y, Brenner D. New therapies for hepatic fibrosis. Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S75-9. PMID: 26206573; PMCID: PMC4734896.
      27. Kim IH, Kisseleva T, Brenner D. Aging and liver disease. Curr Opin Gastroenterol. 2015 May; 31(3):184-91. PMID: 25850346; PMCID: PMC4736713.
      28. Seki E, Brenner D. Recent advancement of molecular mechanisms of liver fibrosis. J Hepatobiliary Pancreat Sci. 2015 Jul; 22(7):512-8. PMID: 25869468; PMCID: PMC4668270.
      29. Loomba R, Sirlin CB, Ang B, Bettencourt R, Jain R, Salotti J, Soaft L, Hooker J, Kono Y, Bhatt A, Hernandez L, Nguyen P, Noureddin M, Haufe W, Hooker C, Yin M, Ehman R, Lin GY, Valasek MA, Brenner D, Richards L. Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). Hepatology. 2015 Apr; 61(4):1239-50. PMID: 25482832; PMCID: PMC4407930.
      30. Xu J, Cong M, Park TJ, Scholten D, Brenner D, Kisseleva T. Contribution of bone marrow-derived fibrocytes to liver fibrosis. Hepatobiliary Surg Nutr. 2015 Feb; 4(1):34-47. PMID: 25713803; PMCID: PMC4318956.
      31. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA, Miyamoto Y, Eckmann L, Dhungana S, Pathmasiri W, Sumner S, Westwater C, Brenner D, Schnabl B. Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice. FASEB J. 2015 Mar; 29(3):1043-55. PMID: 25466902; PMCID: PMC4422368.
      32. Loomba R, Wolfson T, Ang B, Hooker J, Behling C, Peterson M, Valasek M, Lin G, Brenner D, Gamst A, Ehman R, Sirlin C. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. Hepatology. 2014 Dec; 60(6):1920-8. PMID: 25103310; PMCID: PMC4245360.
      33. Xu J, Liu X, Gao B, Karin M, Tsukamoto H, Brenner D, Kisseleva T. New Approaches for Studying Alcoholic Liver Disease. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. PMID: 26594598.
        View in: PubMed
      34. Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA, Hofmann AF, Iida T, Glass CK, Brenner D, Kisseleva T. Origin of myofibroblasts in the fibrotic liver in mice. Proc Natl Acad Sci U S A. 2014 Aug 12; 111(32):E3297-305. PMID: 25074909; PMCID: PMC4136601.
      35. Lopez-Sanchez I, Dunkel Y, Roh YS, Mittal Y, De Minicis S, Muranyi A, Singh S, Shanmugam K, Aroonsakool N, Murray F, Ho SB, Seki E, Brenner D, Ghosh P. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. Nat Commun. 2014 Jul 21; 5:4451. PMID: 25043713; PMCID: PMC4107319.
      36. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner D, Seki E. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014 Aug; 124(8):3566-78. PMID: 24983318; PMCID: PMC4109552.
      37. Moore-Morris T, Guimarães-Camboa N, Banerjee I, Zambon AC, Kisseleva T, Velayoudon A, Stallcup WB, Gu Y, Dalton ND, Cedenilla M, Gomez-Amaro R, Zhou B, Brenner D, Peterson KL, Chen J, Evans SM. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. J Clin Invest. 2014 Jul; 124(7):2921-34. PMID: 24937432; PMCID: PMC4071409.
      38. Paik YH, Kim J, Aoyama T, De Minicis S, Bataller R, Brenner D. Role of NADPH oxidases in liver fibrosis. Antioxid Redox Signal. 2014 Jun 10; 20(17):2854-72. PMID: 24040957; PMCID: PMC4026397.
      39. Liu C, Chen X, Yang L, Kisseleva T, Brenner D, Seki E. Transcriptional repression of the transforming growth factor ß (TGF-ß) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor ?B (NF-?B) p50 enhances TGF-ß signaling in hepatic stellate cells. J Biol Chem. 2014 Mar 07; 289(10):7082-91. PMID: 24448807; PMCID: PMC3945368.
      40. Schnabl B, Brenner D. Interactions between the intestinal microbiome and liver diseases. Gastroenterology. 2014 May; 146(6):1513-24. PMID: 24440671; PMCID: PMC3996054.
      41. Brenner D. Fra, Fra away: the complex role of activator protein 1 in liver injury. Hepatology. 2014 Jan; 59(1):19-20. PMID: 23904356.
        View in: PubMed
      42. Brenner D. Reversibility of liver fibrosis. Gastroenterol Hepatol (N Y). 2013 Nov; 9(11):737-9. PMID: 24764791; PMCID: PMC3995196.
      43. Noureddin M, Lam J, Peterson MR, Middleton M, Hamilton G, Le TA, Bettencourt R, Changchien C, Brenner D, Sirlin C, Loomba R. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Hepatology. 2013 Dec; 58(6):1930-40. PMID: 23696515; PMCID: PMC4819962.
      44. Liu X, Xu J, Brenner D, Kisseleva T. Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. Curr Pathobiol Rep. 2013 Sep; 1(3):209-214. PMID: 24000319.
        View in: PubMed
      45. De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Millán C, Brenner D, Vivarelli M, Mocchegiani F, Marzioni M, Benedetti A, Svegliati-Baroni G. Semaphorin 7A contributes to TGF-ß-mediated liver fibrogenesis. Am J Pathol. 2013 Sep; 183(3):820-30. PMID: 23850082.
        View in: PubMed
      46. Loomba R, Liu J, Yang HI, Lee MH, Lu SN, Wang LY, Iloeje UH, You SL, Brenner D, Chen CJ. Synergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma. Clin Gastroenterol Hepatol. 2013 Dec; 11(12):1636-45.e1-3. PMID: 23669307; PMCID: PMC4100777.
      47. Loomba R, Doycheva I, Bettencourt R, Cohen B, Wassel CL, Brenner D, Barrett-Connor E. Serum ?-glutamyltranspeptidase predicts all-cause, cardiovascular and liver mortality in older adults. J Clin Exp Hepatol. 2013 Mar 01; 3(1):4-11. PMID: 23997501.
        View in: PubMed
      48. Meurer SK, Alsamman M, Sahin H, Wasmuth HE, Kisseleva T, Brenner D, Trautwein C, Weiskirchen R, Scholten D. Overexpression of endoglin modulates TGF-ß1-signalling pathways in a novel immortalized mouse hepatic stellate cell line. PLoS One. 2013; 8(2):e56116. PMID: 23437087; PMCID: PMC3577806.
      49. Miura K, Yang L, van Rooijen N, Brenner D, Ohnishi H, Seki E. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Hepatology. 2013 Feb; 57(2):577-89. PMID: 22987396; PMCID: PMC3566276.
      50. Loomba R, Yang HI, Su J, Brenner D, Barrett-Connor E, Iloeje U, Chen CJ. Synergism between obesity and alcohol in increasing the risk of hepatocellular carcinoma: a prospective cohort study. Am J Epidemiol. 2013 Feb 15; 177(4):333-42. PMID: 23355498; PMCID: PMC3626057.
      51. Kisseleva T, Brenner D. Inactivation of myofibroblasts during regression of liver fibrosis. Cell Cycle. 2013 Feb 01; 12(3):381-2. PMID: 23324345; PMCID: PMC3587431.
      52. Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C, Page P, Brenner D. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology. 2012 Dec; 56(6):2316-27. PMID: 22806357; PMCID: PMC3493679.
      53. Brenner D. Next-generation academic medicine. J Clin Invest. 2012 Nov; 122(11):4280-2. PMID: 23114607; PMCID: PMC3484473.
      54. Hartmann P, Haimerl M, Mazagova M, Brenner D, Schnabl B. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. Gastroenterology. 2012 Nov; 143(5):1330-40.e1. PMID: 22841787; PMCID: PMC3482543.
      55. Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T, Welsh DK, Brenner D, Doyle FJ, Schultz PG, Kay SA. Identification of small molecule activators of cryptochrome. Science. 2012 Aug 31; 337(6098):1094-7. PMID: 22798407; PMCID: PMC3589997.
      56. Le TA, Chen J, Changchien C, Peterson MR, Kono Y, Patton H, Cohen BL, Brenner D, Sirlin C, Loomba R. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Hepatology. 2012 Sep; 56(3):922-32. PMID: 22431131; PMCID: PMC3400720.
      57. Schnabl B, Brenner D. Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis. Gut. 2013 Mar; 62(3):335-6. PMID: 22717452; PMCID: PMC4077319.
      58. Seki E, Brenner D, Karin M. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology. 2012 Aug; 143(2):307-20. PMID: 22705006; PMCID: PMC3523093.
      59. Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, Österreicher CH, Stickel F, Ley K, Brenner D, Kisseleva T. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Gastroenterology. 2012 Sep; 143(3):765-776.e3. PMID: 22687286; PMCID: PMC3635475.
      60. Brenner D, Kisseleva T, Scholten D, Paik YH, Iwaisako K, Inokuchi S, Schnabl B, Seki E, De Minicis S, Oesterreicher C, Taura K. Origin of myofibroblasts in liver fibrosis. Fibrogenesis Tissue Repair. 2012; 5(Suppl 1):S17. PMID: 23259769; PMCID: PMC3368775.
      61. Kisseleva T, Cong M, Paik Y, Scholten D, Jiang C, Benner C, Iwaisako K, Moore-Morris T, Scott B, Tsukamoto H, Evans SM, Dillmann W, Glass CK, Brenner D. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):9448-53. PMID: 22566629; PMCID: PMC3386114.
      62. Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y, Sirlin C, Yu E, Yu RT, Downes M, Evans RM, Brenner D, Schnabl B. Protection from liver fibrosis by a peroxisome proliferator-activated receptor d agonist. Proc Natl Acad Sci U S A. 2012 May 22; 109(21):E1369-76. PMID: 22538808; PMCID: PMC3361396.
      63. Lee JK, Bettencourt R, Brenner D, Le TA, Barrett-Connor E, Loomba R. Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study. PLoS One. 2012; 7(4):e34218. PMID: 22514624; PMCID: PMC3325993.
      64. Iwaisako K, Brenner D, Kisseleva T. What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:65-8. PMID: 22320919; PMCID: PMC4841268.
      65. Kisseleva T, Brenner D. The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis. J Hepatol. 2012 Apr; 56(4):965-72. PMID: 22173163; PMCID: PMC3307836.
      66. Paik YH, Brenner D. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. Korean J Hepatol. 2011 Dec; 17(4):251-7. PMID: 22310788; PMCID: PMC3304665.
      67. Dong MH, Bettencourt R, Brenner D, Barrett-Connor E, Loomba R. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. Clin Gastroenterol Hepatol. 2012 Mar; 10(3):285-90.e1. PMID: 22020064; PMCID: PMC3288181.
      68. Brenner D, Seki E, Taura K, Kisseleva T, Deminicis S, Iwaisako K, Inokuchi S, Schnabl B, Oesterreicher CH, Paik YH, Miura K, Kodama Y. Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. Hepatol Res. 2011 Jul; 41(7):683-6. PMID: 21711427; PMCID: PMC3341613.
      69. Scholten D, Reichart D, Paik YH, Lindert J, Bhattacharya J, Glass CK, Brenner D, Kisseleva T. Migration of fibrocytes in fibrogenic liver injury. Am J Pathol. 2011 Jul; 179(1):189-98. PMID: 21703401; PMCID: PMC3123781.
      70. Paik YH, Iwaisako K, Seki E, Inokuchi S, Schnabl B, Osterreicher CH, Kisseleva T, Brenner D. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Hepatology. 2011 May; 53(5):1730-41. PMID: 21384410; PMCID: PMC3082608.
      71. DeLeve LD, Jaeschke H, Kalra VK, Asahina K, Brenner D, Tsukamoto H. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Liver Int. 2011 Jul; 31(6):762-72. PMID: 21645207; PMCID: PMC4388239.
      72. Kisseleva T, von Köckritz-Blickwede M, Reichart D, McGillvray SM, Wingender G, Kronenberg M, Glass CK, Nizet V, Brenner D. Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection. J Mol Med (Berl). 2011 Oct; 89(10):997-1013. PMID: 21499735; PMCID: PMC3171633.
      73. Inokuchi S, Tsukamoto H, Park E, Liu ZX, Brenner D, Seki E. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol Clin Exp Res. 2011 Aug; 35(8):1509-18. PMID: 21463341; PMCID: PMC3131439.
      74. Kisseleva T, Brenner D. Anti-fibrogenic strategies and the regression of fibrosis. Best Pract Res Clin Gastroenterol. 2011 Apr; 25(2):305-17. PMID: 21497747; PMCID: PMC3086317.
      75. Chau BN, Brenner D. What goes up must come down: the emerging role of microRNA in fibrosis. Hepatology. 2011 Jan; 53(1):4-6. PMID: 21254156.
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      76. Parsons CJ, Stefanovic B, Seki E, Aoyama T, Latour AM, Marzluff WF, Rippe RA, Brenner D. Mutation of the 5'-untranslated region stem-loop structure inhibits a1(I) collagen expression in vivo. J Biol Chem. 2011 Mar 11; 286(10):8609-19. PMID: 21193410; PMCID: PMC3048743.
      77. Österreicher CH, Penz-Österreicher M, Grivennikov SI, Guma M, Koltsova EK, Datz C, Sasik R, Hardiman G, Karin M, Brenner D. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):308-13. PMID: 21173249; PMCID: PMC3017162.
      78. Yan AW, Fouts DE, Brandl J, Stärkel P, Torralba M, Schott E, Tsukamoto H, Nelson KE, Brenner D, Schnabl B. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Hepatology. 2011 Jan; 53(1):96-105. PMID: 21254165; PMCID: PMC3059122.
      79. Aoyama T, Inokuchi S, Brenner D, Seki E. CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. Hepatology. 2010 Oct; 52(4):1390-400. PMID: 20683935; PMCID: PMC2947579.
      80. De Minicis S, Seki E, Paik YH, Osterreicher CH, Kodama Y, Kluwe J, Torozzi L, Miyai K, Benedetti A, Schwabe RF, Brenner D. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Hepatology. 2010 Oct; 52(4):1420-30. PMID: 20690191; PMCID: PMC2947612.
      81. Zhang EE, Liu Y, Dentin R, Pongsawakul PY, Liu AC, Hirota T, Nusinow DA, Sun X, Landais S, Kodama Y, Brenner D, Montminy M, Kay SA. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med. 2010 Oct; 16(10):1152-6. PMID: 20852621; PMCID: PMC2952072.
      82. Loomba R, Yang HI, Su J, Brenner D, Iloeje U, Chen CJ. Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. Clin Gastroenterol Hepatol. 2010 Oct; 8(10):891-8, 898.e1-2. PMID: 20621202.
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      83. Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G, Brenner D, Kisseleva T. Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Gastroenterology. 2010 Sep; 139(3):987-98. PMID: 20546735; PMCID: PMC2930026.
      84. Loomba R, Rao F, Zhang L, Khandrika S, Ziegler MG, Brenner D, O'Connor DT. Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins. Gastroenterology. 2010 Sep; 139(3):836-45, 845.e1. PMID: 20537997; PMCID: PMC3038676.
      85. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H, Olefsky JM, Brenner D, Seki E. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology. 2010 Jul; 139(1):323-34.e7. PMID: 20347818; PMCID: PMC4631262.
      86. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K, Brenner D, Ginès P, Bataller R. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. Hepatology. 2010 Mar; 51(3):942-52. PMID: 20044807.
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      87. Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M, Brenner D. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology. 2010 Mar; 51(3):1027-36. PMID: 20052656; PMCID: PMC2906231.
      88. Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S, Brenner D, Seki E. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):844-9. PMID: 20080763; PMCID: PMC2818947.
      89. Osterreicher CH, Taura K, De Minicis S, Seki E, Penz-Osterreicher M, Kodama Y, Kluwe J, Schuster M, Oudit GY, Penninger JM, Brenner D. Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology. 2009 Sep; 50(3):929-38. PMID: 19650157; PMCID: PMC4734904.
      90. Brafman DA, de Minicis S, Seki E, Shah KD, Teng D, Brenner D, Willert K, Chien S. Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Integr Biol (Camb). 2009 Sep; 1(8-9):513-24. PMID: 20023766.
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      91. Seki E, De Minicis S, Gwak GY, Kluwe J, Inokuchi S, Bursill CA, Llovet JM, Brenner D, Schwabe RF. CCR1 and CCR5 promote hepatic fibrosis in mice. J Clin Invest. 2009 Jul; 119(7):1858-70. PMID: 19603542; PMCID: PMC2701864.
      92. Seki E, de Minicis S, Inokuchi S, Taura K, Miyai K, van Rooijen N, Schwabe RF, Brenner D. CCR2 promotes hepatic fibrosis in mice. Hepatology. 2009 Jul; 50(1):185-97. PMID: 19441102; PMCID: PMC2705470.
      93. Kodama Y, Kisseleva T, Iwaisako K, Miura K, Taura K, De Minicis S, Osterreicher CH, Schnabl B, Seki E, Brenner D. c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. Gastroenterology. 2009 Oct; 137(4):1467-1477.e5. PMID: 19549522; PMCID: PMC2757473.
      94. Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y, Brenner D. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. Gastroenterology. 2009 Apr; 136(4):1423-34. PMID: 19249395.
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      95. Brenner D. Molecular pathogenesis of liver fibrosis. Trans Am Clin Climatol Assoc. 2009; 120:361-8. PMID: 19768189; PMCID: PMC2744540.
      96. De Minicis S, Seki E, Oesterreicher C, Schnabl B, Schwabe RF, Brenner D. Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. Hepatology. 2008 Dec; 48(6):2016-26. PMID: 19025999.
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      97. Miura K, Taura K, Kodama Y, Schnabl B, Brenner D. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Hepatology. 2008 Nov; 48(5):1420-9. PMID: 18671304.
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      98. Notas G, Kisseleva T, Brenner D. NK and NKT cells in liver injury and fibrosis. Clin Immunol. 2009 Jan; 130(1):16-26. PMID: 18823822.
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      99. Taura K, De Minicis S, Seki E, Hatano E, Iwaisako K, Osterreicher CH, Kodama Y, Miura K, Ikai I, Uemoto S, Brenner D. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Gastroenterology. 2008 Nov; 135(5):1729-38. PMID: 18823985.
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      100. Schnabl B, Scholten D, Brenner D. What is the potential role of antifibrotic agents for the treatment of liver disease? Nat Clin Pract Gastroenterol Hepatol. 2008 Sep; 5(9):496-7. PMID: 18628735.
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      101. Seki E, Brenner D. Toll-like receptors and adaptor molecules in liver disease: update. Hepatology. 2008 Jul; 48(1):322-35. PMID: 18506843.
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      102. Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA, Brenner D, Morrow JD, Boutaud O, Oates JA. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. J Clin Invest. 2008 Jun; 118(6):2121-31. PMID: 18451993; PMCID: PMC2350426.
      103. Kisseleva T, Brenner D. Fibrogenesis of parenchymal organs. Proc Am Thorac Soc. 2008 Apr 15; 5(3):338-42. PMID: 18403330; PMCID: PMC2645245.
      104. De Minicis S, Brenner D. Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. J Gastroenterol Hepatol. 2008 Mar; 23 Suppl 1:S98-103. PMID: 18336675.
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      105. Adachi M, Brenner D. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. Hepatology. 2008 Feb; 47(2):677-85. PMID: 18220291.
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      106. Kisseleva T, Brenner D. Mechanisms of fibrogenesis. Exp Biol Med (Maywood). 2008 Feb; 233(2):109-22. PMID: 18222966.
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      107. Kisseleva T, Brenner D. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. J Gastroenterol Hepatol. 2007 Jun; 22 Suppl 1:S73-8. PMID: 17567473.
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      108. Seki E, Brenner D. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? J Hepatol. 2007 Aug; 47(2):307-9. PMID: 17566588; PMCID: PMC2739234.
      109. De Minicis S, Brenner D. NOX in liver fibrosis. Arch Biochem Biophys. 2007 Jun 15; 462(2):266-72. PMID: 17531188; PMCID: PMC2727549.
      110. Osterreicher CH, Brenner D. The genetics of nonalcoholic fatty liver disease. Ann Hepatol. 2007 Apr-Jun; 6(2):83-8. PMID: 17519829.
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      111. Osawa Y, Seki E, Adachi M, Taura K, Kodama Y, Siegmund SV, Schwabe RF, Brenner D. Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. Liver Int. 2006 Nov; 26(9):1138-47. PMID: 17032415.
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      112. Uchinami H, Seki E, Brenner D, D'Armiento J. Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis. Hepatology. 2006 Aug; 44(2):420-9. PMID: 16871591.
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      113. Kisseleva T, Uchinami H, Feirt N, Quintana-Bustamante O, Segovia JC, Schwabe RF, Brenner D. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. J Hepatol. 2006 Sep; 45(3):429-38. PMID: 16846660.
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      114. Yang L, Bataller R, Dulyx J, Coffman TM, Ginès P, Rippe RA, Brenner D. Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. J Hepatol. 2005 Aug; 43(2):317-23. PMID: 15964094.
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      115. Luedde T, Assmus U, Wüstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K, Brenner D, Manns MP, Pasparakis M, Trautwein C. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J Clin Invest. 2005 Apr; 115(4):849-59. PMID: 15776110; PMCID: PMC1064982.
      116. Bataller R, Brenner D. Liver fibrosis. J Clin Invest. 2005 Feb; 115(2):209-18. PMID: 15690074; PMCID: PMC546435.
      117. Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ, Brenner D. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest. 2003 Nov; 112(9):1383-94. PMID: 14597764; PMCID: PMC228420.
      118. Kweon YO, Paik YH, Schnabl B, Qian T, Lemasters JJ, Brenner D. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. J Hepatol. 2003 Jul; 39(1):38-46. PMID: 12821042.
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