David Brenner

Title(s)Vice Chancellor - Health Sciences, School of Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0602
La Jolla CA 92093
Phone858-534-1501
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    Other Positions
    Title(s)Dean - School of Medicine


    Collapse Biography 
    Collapse Education and Training
    UC San DiegoFellowship1988Gastroenterology
    NIH/NIDDK, Bethesda, MDFellowship1986Genetics & Biochemistry
    Yale UniversityIntern & Residency1985Internal Medicine
    Yale UniversityMD1979Medicine
    Yale UniversityBS1975Biology

    Collapse Research 
    Collapse Research Activities and Funding
    Microbiome as Therapeutic Target in Alcoholic Hepatitis
    NIH U01AA021856Jun 1, 2013 - May 31, 2019
    Role: Principal Investigator
    The Role of Inflammation and Stroma in Digestive Cancer
    NIH U54CA126513Sep 30, 2006 - Sep 21, 2011
    Role: Co-Investigator
    Angiotensin II and NADPH Oxidase in Hepatic Fibrosis
    NIH R01DK072237Sep 15, 2005 - Jun 30, 2011
    Role: Principal Investigator
    Hepatic Stellate Cell Activation induced by Hepatitis C Virus
    NIH R01AA015055Sep 30, 2003 - Aug 31, 2009
    Role: Principal Investigator
    Cond. Acceptance Post-Bac. Prog. Scholarship Fund
    NIH S22MD000227Sep 30, 2002 - Sep 29, 2005
    Role: Principal Investigator
    Molecular Pathogenesis of Apoptosis in Liver Cells
    NIH P01DK059340Sep 21, 2001 - May 31, 2006
    Role: Co-Investigator
    ONCOGENIC K-RAS INDUCTION OF GASTRIN GENE TRANSCRIPTION
    NIH R01DK055686Aug 15, 2000 - Jul 31, 2006
    Role: Principal Investigator
    GENE TECHNOLOGY THERAPY AND ALCOHOL-INDUCED FIBROSIS
    NIH R01AA012586Sep 23, 1999 - Jun 30, 2003
    Role: Principal Investigator
    The Southern California Research Center for ALPD and Cirrhosis
    NIH P50AA011999Jan 1, 1999 - Dec 31, 2023
    Role: Co-Investigator
    Molecular and Cellular Pathogenesis in Alcoholism
    NIH P60AA011605Dec 1, 1997 - Nov 30, 2017
    Role: Co-Investigator
    MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM
    NIH P50AA011605Dec 1, 1997 - Nov 30, 2002
    Role: Co-Investigator
    RAT MODEL OF ALCOHOLIC PANCREATITIS
    NIH R03AA011226Apr 1, 1997 - Mar 31, 1999
    Role: Principal Investigator
    Gastroenterology Research Training
    NIH T32DK007737Aug 1, 1996 - Jun 30, 2026
    Role: Principal Investigator
    GENE THERAPY FOR LIVER DISEASES
    NIH R13DK047627Jan 20, 1994 - Oct 31, 1994
    Role: Principal Investigator
    MOLECULAR DEFECTS IN PROTOPORPHYRIA
    NIH R01DK047361May 1, 1993 - May 31, 2004
    Role: Principal Investigator
    Integrated Center for InVivo Microscopy
    NIH P41RR005959Sep 1, 1990 - Jun 30, 2013
    Role: Co-Investigator
    FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS
    NIH P01CA050528Sep 8, 1989 - Jan 31, 1998
    Role: Co-Investigator
    Molecular Mechanisms by which TNFalpha Modulates Fibrosis
    NIH R01GM041804Apr 1, 1989 - Dec 31, 2014
    Role: Principal Investigator
    MOLECULAR DEFECT IN PROTOPORPHYRIA
    NIH R29DK039996Apr 1, 1988 - Mar 31, 1993
    Role: Principal Investigator
    General Clinical Research Center
    NIH M01RR000827Mar 1, 1974 - Nov 30, 2010
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH. Cell Metab. 2022 Jun 04. Gao H, Jin Z, Bandyopadhyay G, Cunha E Rocha K, Liu X, Zhao H, Zhang D, Jouihan H, Pourshahian S, Kisseleva T, Brenner DA, Ying W, Olefsky JM. PMID: 35700738.
      View in: PubMed   Mentions:
    2. Quadruple genetic variants in a sporadic ALS patient. Mol Genet Genomic Med. 2022 Apr 14; e1953. Yilmaz R, Weishaupt K, Valkadinov I, Knehr A, Brenner D, Weishaupt JH. PMID: 35426263.
      View in: PubMed   Mentions:
    3. Wastewater sequencing uncovers early, cryptic SARS-CoV-2 variant transmission. medRxiv. 2022 Apr 04. Karthikeyan S, Levy JI, De Hoff P, Humphrey G, Birmingham A, Jepsen K, Farmer S, Tubb HM, Valles T, Tribelhorn CE, Tsai R, Aigner S, Sathe S, Moshiri N, Henson B, Mark AM, Hakim A, Baer NA, Barber T, Belda-Ferre P, Chacón M, Cheung W, Cresini ES, Eisner ER, Lastrella AL, Lawrence ES, Marotz CA, Ngo TT, Ostrander T, Plascencia A, Salido RA, Seaver P, Smoot EW, McDonald D, Neuhard RM, Scioscia AL, Satterlund AM, Simmons EH, Abelman DB, Brenner D, Bruner JC, Buckley A, Ellison M, Gattas J, Gonias SL, Hale M, Hawkins F, Ikeda L, Jhaveri H, Johnson T, Kellen V, Kremer B, Matthews G, McLawhon RW, Ouillet P, Park D, Pradenas A, Reed S, Riggs L, Sanders A, Sollenberger B, Song A, White B, Winbush T, Aceves CM, Anderson C, Gangavarapu K, Hufbauer E, Kurzban E, Lee J, Matteson NL, Parker E, Perkins SA, Ramesh KS, Robles-Sikisaka R, Schwab MA, Spencer E, Wohl S, Nicholson L, Mchardy IH, Dimmock DP, Hobbs CA, Bakhtar O, Harding A, Mendoza A, Bolze A, Becker D, Cirulli ET, Isaksson M, Schiabor Barrett KM, Washington NL, Malone JD, Schafer AM, Gurfield N, Stous S, Fielding-Miller R, Garfein RS, Gaines T, Anderson C, Martin NK, Schooley R, Austin B, MacCannell DR, Kingsmore SF, Lee W, Shah S, McDonald E, Yu AT, Zeller M, Fisch KM, Longhurst C, Maysent P, Pride D, Khosla PK, Laurent LC, Yeo GW, Andersen KG, Knight R. PMID: 35411350; PMCID: PMC8996633.
      View in: PubMed   Mentions:
    4. The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis. Front Mol Biosci. 2021; 8:790032. Fuji H, Miller G, Nishio T, Koyama Y, Lam K, Zhang V, Loomba R, Brenner D, Kisseleva T. PMID: 34966784; PMCID: PMC8710774.
      View in: PubMed   Mentions:
    5. CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease. Nat Commun. 2021 12 09; 12(1):7172. Duan Y, Chu H, Brandl K, Jiang L, Zeng S, Meshgin N, Papachristoforou E, Argemi J, Mendes BG, Wang Y, Su H, Sun W, Llorente C, Hendrikx T, Liu X, Hosseini M, Kisseleva T, Brenner DA, Bataller R, Ramachandran P, Karin M, Fu W, Schnabl B. PMID: 34887405; PMCID: PMC8660815.
      View in: PubMed   Mentions:
    6. PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells. PLoS One. 2021; 16(12):e0260721. Rady B, Nishio T, Dhar D, Liu X, Erion M, Kisseleva T, Brenner DA, Pocai A. PMID: 34879108; PMCID: PMC8654208.
      View in: PubMed   Mentions:
    7. Heterogeneity of HSCs in a Mouse Model of NASH. Hepatology. 2021 08; 74(2):667-685. Rosenthal SB, Liu X, Ganguly S, Dhar D, Pasillas MP, Ricciardelli E, Li RZ, Troutman TD, Kisseleva T, Glass CK, Brenner DA. PMID: 33550587; PMCID: PMC8346581.
      View in: PubMed   Mentions: 1     Fields:    
    8. Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis. Proc Natl Acad Sci U S A. 2021 07 20; 118(29). Nishio T, Koyama Y, Liu X, Rosenthal SB, Yamamoto G, Fuji H, Baglieri J, Li N, Brenner LN, Iwaisako K, Taura K, Hagood JS, LaRusso NF, Bera TK, Pastan I, Brenner DA, Kisseleva T. PMID: 34253615; PMCID: PMC8307749.
      View in: PubMed   Mentions: 1     Fields:    
    9. Mutation of the 5'-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice. Am J Physiol Heart Circ Physiol. 2021 08 01; 321(2):H435-H445. Ramirez-Perez FI, Woodford ML, Morales-Quinones M, Grunewald ZI, Cabral-Amador FJ, Yoshida T, Brenner DA, Manrique-Acevedo C, Martinez-Lemus LA, Chandrasekar B, Padilla J. PMID: 34242094; PMCID: PMC8526337.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice. Am J Pathol. 2021 09; 191(9):1564-1579. Baglieri J, Zhang C, Liang S, Liu X, Nishio T, Rosenthal SB, Dhar D, Su H, Cong M, Jia J, Hosseini M, Karin M, Kisseleva T, Brenner DA. PMID: 34119473; PMCID: PMC8406794.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. Cell Mol Gastroenterol Hepatol. 2021; 12(3):891-920. Ganguly S, Muench GA, Shang L, Rosenthal SB, Rahman G, Wang R, Wang Y, Kwon HC, Diomino AM, Kisseleva T, Soorosh P, Hosseini M, Knight R, Schnabl B, Brenner DA, Dhar D. PMID: 34062281; PMCID: PMC8342972.
      View in: PubMed   Mentions: 1     Fields:    
    12. Intestinal α1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice. Cell Mol Gastroenterol Hepatol. 2021; 12(1):293-320. Zhou R, Llorente C, Cao J, Zaramela LS, Zeng S, Gao B, Li SZ, Welch RD, Huang FQ, Qi LW, Pan C, Huang Y, Zhou P, Beussen I, Zhang Y, Bryam G, Fiehn O, Wang L, Liu EH, Yu RT, Downes M, Evans RM, Goglin K, Fouts DE, Brenner DA, Bode L, Fan X, Zengler K, Schnabl B. PMID: 33631374; PMCID: PMC8166943.
      View in: PubMed   Mentions: 1     Fields:    
    13. Previous liver regeneration induces fibro-protective mechanisms during thioacetamide-induced chronic liver injury. Int J Biochem Cell Biol. 2021 05; 134:105933. Gratte FD, Pasic S, Abu Bakar NDB, Gogoi-Tiwari J, Liu X, Carlessi R, Kisseleva T, Brenner DA, Ramm GA, Olynyk JK, Tirnitz-Parker JEE. PMID: 33540107.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    14. The genetic landscape of axonal neuropathies in the middle-aged and elderly: Focus on MME. Neurology. 2020 12 15; 95(24):e3163-e3179. Senderek J, Lassuthova P, Kabzinska D, Abreu L, Baets J, Beetz C, Braathen GJ, Brenner D, Dalton J, Dankwa L, Deconinck T, De Jonghe P, Dräger B, Eggermann K, Ellis M, Fischer C, Stojkovic T, Herrmann DN, Horvath R, Høyer H, Iglseder S, Kennerson M, Kinslechner K, Kohler JN, Kurth I, Laing NG, Lamont PJ, Wolfgang N L, Ludolph A, Marques W, Nicholson G, Ong R, Petri S, Ravenscroft G, Rebelo A, Ricci G, Rudnik-Schöneborn S, Schirmacher A, Schlotter-Weigel B, Schoels L, Schüle R, Synofzik M, Francou B, Strom TM, Wagner J, Walk D, Wanschitz J, Weinmann D, Weishaupt J, Wiessner M, Windhager R, Young P, Züchner S, Toegel S, Seeman P, Kochanski A, Auer-Grumbach M. PMID: 33144514; PMCID: PMC7836667.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Cell Metab. 2020 Nov 03; 32(5):901. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T, Brenner DA, Sirlin CB, Downes M, Evans RM, Loomba R. PMID: 33147487; PMCID: PMC7891106.
      View in: PubMed   Mentions: 8     Fields:    
    16. Molecular and cellular mechanisms of liver fibrosis and its regression. Nat Rev Gastroenterol Hepatol. 2021 03; 18(3):151-166. Kisseleva T, Brenner D. PMID: 33128017.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    17. Traditional Chinese Medicine Fuzheng Huayu Prevents Development of Liver Fibrosis in Mice. Arch Clin Biomed Res. 2020; 4(5):561-580. Jiang C, Iwaisako K, Cong M, Diggle K, Hassanein T, Brenner DA, Kisseleva T. PMID: 33210080; PMCID: PMC7671588.
      View in: PubMed   Mentions: 1  
    18. Intestinal Virome in Patients With Alcoholic Hepatitis. Hepatology. 2020 12; 72(6):2182-2196. Jiang L, Lang S, Duan Y, Zhang X, Gao B, Chopyk J, Schwanemann LK, Ventura-Cots M, Bataller R, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS, Vargas V, Altamirano J, Caballería J, Shawcross DL, Ho SB, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Kisseleva T, Brenner DA, Tu XM, Stärkel P, Pride D, Fouts DE, Schnabl B. PMID: 32654263; PMCID: PMC8159727.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    19. Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice. Exp Neurol. 2021 01; 335:113496. Sieverding K, Ulmer J, Bruno C, Satoh T, Tsao W, Freischmidt A, Akira S, Wong PC, Ludolph AC, Danzer KM, Lobsiger CS, Brenner D, Weishaupt JH. PMID: 33038415.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    20. Study of loneliness and wisdom in 482 middle-aged and oldest-old adults: a comparison between people in Cilento, Italy and San Diego, USA. Aging Ment Health. 2021 11; 25(11):2149-2159. Jeste DV, Di Somma S, Lee EE, Nguyen TT, Scalcione M, Biaggi A, Daly R, Liu J, Tu X, Ziedonis D, Glorioso D, Antonini P, Brenner D. PMID: 33000647; PMCID: PMC8012404.
      View in: PubMed   Mentions: 5     Fields:    
    21. Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. Brain Commun. 2020; 2(2):fcaa133. Bruno C, Sieverding K, Freischmidt A, Satoh T, Walther P, Mayer B, Ludolph AC, Akira S, Yilmazer-Hanke D, Danzer KM, Lobsiger CS, Brenner D, Weishaupt JH. PMID: 33005894; PMCID: PMC7519725.
      View in: PubMed   Mentions: 3  
    22. Western Diet Promotes Renal Injury, Inflammation, and Fibrosis in a Murine Model of Alström Syndrome. Nephron. 2020; 144(8):400-412. Kim YC, Ganguly S, Nespoux J, Freeman B, Zhang H, Brenner D, Dhar D, Vallon V. PMID: 32629454; PMCID: PMC8011852.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    23. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Cell Metab. 2020 11 03; 32(5):878-888.e6. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T, Brenner DA, Sirlin CB, Downes M, Evans RM, Loomba R. PMID: 32610095; PMCID: PMC7822714.
      View in: PubMed   Mentions: 18     Fields:    
    24. Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2α-dependent mechanism. Mol Metab. 2020 11; 41:101039. Riopel M, Moon JS, Bandyopadhyay GK, You S, Lam K, Liu X, Kisseleva T, Brenner D, Lee YS. PMID: 32534258; PMCID: PMC7393408.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    25. Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis. PLoS One. 2020; 15(6):e0234038. Baeza-Raja B, Goodyear A, Liu X, Lam K, Yamamoto L, Li Y, Dodson GS, Takeuchi T, Kisseleva T, Brenner DA, Dabbagh K. PMID: 32492075; PMCID: PMC7269334.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    26. Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). Medicina (Kaunas). 2020 May 05; 56(5). Pizza V, Antonini P, Marino R, D'Arena G, Lucibello SG, Rizzo M, Brenner DA, Jeste DV, Somma SD. PMID: 32380778; PMCID: PMC7279440.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. Front Physiol. 2020; 11:370. Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L, Loomba R, Brenner DA, Stärkel P, Schnabl B. PMID: 32390870; PMCID: PMC7193112.
      View in: PubMed   Mentions: 3  
    28. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. PLoS One. 2020; 15(3):e0229445. Zhang M, Haughey M, Wang NY, Blease K, Kapoun AM, Couto S, Belka I, Hoey T, Groza M, Hartke J, Bennett B, Cain J, Gurney A, Benish B, Castiglioni P, Drew C, Lachowicz J, Carayannopoulos L, Nathan SD, Distler J, Brenner DA, Hariharan K, Cho H, Xie W. PMID: 32160239; PMCID: PMC7065809.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    29. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. JCI Insight. 2020 02 13; 5(3). Xu J, Ma HY, Liu X, Rosenthal S, Baglieri J, McCubbin R, Sun M, Koyama Y, Geoffroy CG, Saijo K, Shang L, Nishio T, Maricic I, Kreifeldt M, Kusumanchi P, Roberts A, Zheng B, Kumar V, Zengler K, Pizzo DP, Hosseini M, Contet C, Glass CK, Liangpunsakul S, Tsukamoto H, Gao B, Karin M, Brenner DA, Koob GF, Kisseleva T. PMID: 32051339; PMCID: PMC7098802.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    30. Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. Hepatol Commun. 2020 Apr; 4(4):606-626. Liu X, Rosenthal SB, Meshgin N, Baglieri J, Musallam SG, Diggle K, Lam K, Wu R, Pan SQ, Chen Y, Dorko K, Presnell S, Benner C, Hosseini M, Tsukamoto H, Brenner D, Kisseleva T. PMID: 32258954; PMCID: PMC7109347.
      View in: PubMed   Mentions: 5  
    31. Cardiovascular health of nonagenarians in southern Italy: a cross-sectional, home-based pilot study of longevity. J Cardiovasc Med (Hagerstown). 2020 Feb; 21(2):89-98. Daniels LB, Antonini P, Marino R, Rizzo M, Navarin S, Lucibello SG, Maisel AS, Pizza V, Brenner DA, Jeste DV, Di Somma S. PMID: 31789688.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    32. Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution. Gastroenterology. 2020 05; 158(6):1728-1744.e14. Liu X, Xu J, Rosenthal S, Zhang LJ, McCubbin R, Meshgin N, Shang L, Koyama Y, Ma HY, Sharma S, Heinz S, Glass CK, Benner C, Brenner DA, Kisseleva T. PMID: 31982409; PMCID: PMC7252905.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    33. Mechanisms of liver fibrosis and its role in liver cancer. Exp Biol Med (Maywood). 2020 01; 245(2):96-108. Dhar D, Baglieri J, Kisseleva T, Brenner DA. PMID: 31924111; PMCID: PMC7016420.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    34. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol. 2020 05; 72(5):946-959. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. PMID: 31899206; PMCID: PMC7167339.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    35. Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Cell Metab. 2020 01 07; 31(1):189-206.e8. Sun X, Seidman JS, Zhao P, Troutman TD, Spann NJ, Que X, Zhou F, Liao Z, Pasillas M, Yang X, Magida JA, Kisseleva T, Brenner DA, Downes M, Evans RM, Saltiel AR, Tsimikas S, Glass CK, Witztum JL. PMID: 31761566; PMCID: PMC7028360.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    36. The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease. Cell Metab. 2019 11 05; 30(5):850-852. Kisseleva T, Brenner DA. PMID: 31693880.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    37. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Cell Metab. 2019 Sep 03; 30(3):607. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C, Bettencourt R, Highlander SK, Jones MB, Sirlin CB, Schnabl B, Brinkac L, Schork N, Chen CH, Brenner DA, Biggs W, Yooseph S, Venter JC, Nelson KE. PMID: 31484056; PMCID: PMC8025688.
      View in: PubMed   Mentions: 14     Fields:    
    38. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Proc Natl Acad Sci U S A. 2019 07 23; 116(30):15184-15193. Wang L, Mazagova M, Pan C, Yang S, Brandl K, Liu J, Reilly SM, Wang Y, Miao Z, Loomba R, Lu N, Guo Q, Liu J, Yu RT, Downes M, Evans RM, Brenner DA, Saltiel AR, Beutler B, Schnabl B. PMID: 31289229; PMCID: PMC6660779.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    39. Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice. J Hepatol. 2019 09; 71(3):573-585. Nishio T, Hu R, Koyama Y, Liang S, Rosenthal SB, Yamamoto G, Karin D, Baglieri J, Ma HY, Xu J, Liu X, Dhar D, Iwaisako K, Taura K, Brenner DA, Kisseleva T. PMID: 31071368.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    40. Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography. Hepatology. 2019 07; 70(1):127-141. Caussy C, Bhargava M, Villesen IF, Gudmann NS, Leeming DJ, Karsdal MA, Faulkner C, Bao D, Liu A, Lo MT, Bettencourt R, Bassirian S, Richards L, Brenner DA, Chen CH, Sirlin CB, Loomba R. PMID: 30859582; PMCID: PMC6984974.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    41. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. Int J Mol Sci. 2019 Apr 07; 20(7). Baglieri J, Brenner DA, Kisseleva T. PMID: 30959975; PMCID: PMC6479943.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    42. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Nat Commun. 2019 03 29; 10(1):1406. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R, Rizo E, Richards L, Xu ZZ, Downes MR, Evans RM, Brenner DA, Sirlin CB, Knight R, Loomba R. PMID: 30926798; PMCID: PMC6440960.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    43. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. J Exp Med. 2019 02 04; 216(2):267-278. Brenner D, Sieverding K, Bruno C, Lüningschrör P, Buck E, Mungwa S, Fischer L, Brockmann SJ, Ulmer J, Bliederhäuser C, Philibert CE, Satoh T, Akira S, Boillée S, Mayer B, Sendtner M, Ludolph AC, Danzer KM, Lobsiger CS, Freischmidt A, Weishaupt JH. PMID: 30635357; PMCID: PMC6363427.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    44. Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease. Gut. 2019 10; 68(10):1884-1892. Caussy C, Ajmera VH, Puri P, Hsu CL, Bassirian S, Mgdsyan M, Singh S, Faulkner C, Valasek MA, Rizo E, Richards L, Brenner DA, Sirlin CB, Sanyal AJ, Loomba R. PMID: 30567742; PMCID: PMC8328048.
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    45. Combatting Fibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis. Hepatol Commun. 2019 Feb; 3(2):180-192. Chen L, Brenner DA, Kisseleva T. PMID: 30766956; PMCID: PMC6357832.
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    46. Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD. Aliment Pharmacol Ther. 2019 01; 49(2):183-193. Caussy C, Hsu C, Singh S, Bassirian S, Kolar J, Faulkner C, Sinha N, Bettencourt R, Gara N, Valasek MA, Schnabl B, Richards L, Brenner DA, Hofmann AF, Loomba R. PMID: 30506692; PMCID: PMC6319963.
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    47. Publisher Correction: The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol. 2018 12; 15(12):785. Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R. PMID: 29785003; PMCID: PMC7133393.
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    48. Of Mice and Men and Nonalcoholic Steatohepatitis. Hepatology. 2018 12; 68(6):2059-2061. Brenner DA. PMID: 30033687; PMCID: PMC6398944.
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    49. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Gastroenterology. 2019 03; 156(4):1156-1172.e6. Liang S, Ma HY, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T, Brenner DA. PMID: 30445007; PMCID: PMC6409207.
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    50. Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians. Clin Gastroenterol Hepatol. 2019 01; 17(2):218-230. Allaband C, McDonald D, Vázquez-Baeza Y, Minich JJ, Tripathi A, Brenner DA, Loomba R, Smarr L, Sandborn WJ, Schnabl B, Dorrestein P, Zarrinpar A, Knight R. PMID: 30240894; PMCID: PMC6391518.
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    51. The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol. 2018 07; 15(7):397-411. Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R. PMID: 29748586; PMCID: PMC6319369.
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    52. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. Hepatology. 2018 09; 68(3):918-932. Caussy C, Hsu C, Lo MT, Liu A, Bettencourt R, Ajmera VH, Bassirian S, Hooker J, Sy E, Richards L, Schork N, Schnabl B, Brenner DA, Sirlin CB, Chen CH, Loomba R, Genetics of NAFLD in Twins Consortium. PMID: 29572891; PMCID: PMC6151296.
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    53. Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2. Hepatology. 2018 09; 68(3):1070-1086. Lan T, Li C, Yang G, Sun Y, Zhuang L, Ou Y, Li H, Wang G, Kisseleva T, Brenner D, Guo J. PMID: 29572892; PMCID: PMC6174945.
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    54. Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. Hepatology. 2018 06; 67(6):2150-2166. Hartmann P, Hochrath K, Horvath A, Chen P, Seebauer CT, Llorente C, Wang L, Alnouti Y, Fouts DE, Stärkel P, Loomba R, Coulter S, Liddle C, Yu RT, Ling L, Rossi SJ, DePaoli AM, Downes M, Evans RM, Brenner DA, Schnabl B. PMID: 29159825; PMCID: PMC5962369.
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    55. Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patients With Nonalcoholic Liver Disease. Clin Gastroenterol Hepatol. 2018 12; 16(12):1974-1982.e7. Caussy C, Chen J, Alquiraish MH, Cepin S, Nguyen P, Hernandez C, Yin M, Bettencourt R, Cachay ER, Jayakumar S, Fortney L, Hooker J, Sy E, Valasek MA, Rizo E, Richards L, Brenner DA, Sirlin CB, Ehman RL, Loomba R. PMID: 29104128; PMCID: PMC6050151.
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    56. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. JCI Insight. 2017 12 21; 2(24). Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D, Kisseleva T, Brenner DA, Urrutia R, Lomberk G, Gao Y, Ligresti G, Tschumperlin DJ, Revzin A, Cao S, Shah VH. PMID: 29263300; PMCID: PMC5752303.
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    57. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. Int Psychogeriatr. 2018 01; 30(1):31-38. Scelzo A, Di Somma S, Antonini P, Montross LP, Schork N, Brenner D, Jeste DV. PMID: 29229012.
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    58. Publisher Correction: Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Nat Commun. 2017 12 12; 8(1):2137. Llorente C, Jepsen P, Inamine T, Wang L, Bluemel S, Wang HJ, Loomba R, Bajaj JS, Schubert ML, Sikaroodi M, Gillevet PM, Xu J, Kisseleva T, Ho SB, DePew J, Du X, Sørensen HT, Vilstrup H, Nelson KE, Brenner DA, Fouts DE, Schnabl B. PMID: 29233961; PMCID: PMC5727102.
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    59. Human hepatic stellate cell isolation and characterization. J Gastroenterol. 2018 01; 53(1):6-17. Shang L, Hosseini M, Liu X, Kisseleva T, Brenner DA. PMID: 29094206.
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    60. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. Hepatol Commun. 2017 12; 1(10):1043-1057. Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R, Quehenberger O, Davidson NO, Dennis EA, Kisseleva T, Brenner DA. PMID: 29404441; PMCID: PMC5721400.
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    61. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Nat Commun. 2017 10 16; 8(1):837. Llorente C, Jepsen P, Inamine T, Wang L, Bluemel S, Wang HJ, Loomba R, Bajaj JS, Schubert ML, Sikaroodi M, Gillevet PM, Xu J, Kisseleva T, Ho SB, DePew J, Du X, Sørensen HT, Vilstrup H, Nelson KE, Brenner DA, Fouts DE, Schnabl B. PMID: 29038503; PMCID: PMC5643518.
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    62. The fecal microbiome of ALS patients. Neurobiol Aging. 2018 01; 61:132-137. Brenner D, Hiergeist A, Adis C, Mayer B, Gessner A, Ludolph AC, Weishaupt JH. PMID: 29065369.
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    63. Thomas E. Starzl: Transplantation pioneer. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):10808-10809. Brenner DA. PMID: 28893997; PMCID: PMC5642726.
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    64. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. J Clin Invest. 2017 Jun 30; 127(7):2697-2704. Caussy C, Soni M, Cui J, Bettencourt R, Schork N, Chen CH, Ikhwan MA, Bassirian S, Cepin S, Gonzalez MP, Mendler M, Kono Y, Vodkin I, Mekeel K, Haldorson J, Hemming A, Andrews B, Salotti J, Richards L, Brenner DA, Sirlin CB, Loomba R, Familial NAFLD Cirrhosis Research Consortium. PMID: 28628033; PMCID: PMC5490764.
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    65. Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. Int J Mol Med. 2017 Aug; 40(2):454-464. Cong M, Zhao W, Liu T, Wang P, Fan X, Zhai Q, Bao X, Zhang D, You H, Kisseleva T, Brenner DA, Jia J, Zhuang H. PMID: 28627620; PMCID: PMC5504991.
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    66. Radiation exposure from depleted uranium: The radiation bystander effect. Toxicol Appl Pharmacol. 2017 09 15; 331:135-141. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P, Brenner D. PMID: 28602947.
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    67. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. Clin Gastroenterol Hepatol. 2017 11; 15(11):1808-1810. Reinders ME, Wardi G, Bettencourt R, Bouland D, Bazick J, Mendler M, Vodkin I, Kalmaz D, Savides T, Brenner D, Sell RE, Loomba R. PMID: 28602970; PMCID: PMC5723019.
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    68. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Cell Metab. 2017 May 02; 25(5):1054-1062.e5. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C, Bettencourt R, Highlander SK, Jones MB, Sirlin CB, Schnabl B, Brinkac L, Schork N, Chen CH, Brenner DA, Biggs W, Yooseph S, Venter JC, Nelson KE. PMID: 28467925; PMCID: PMC5502730.
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    69. Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing. Mol Ther Nucleic Acids. 2017 Jun 16; 7:314-323. Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V, Kisseleva T, Brenner D, Duffield J, Burkly LC. PMID: 28624207; PMCID: PMC5424569.
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    70. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Invest. 2017 Apr 03; 127(4):1254-1270. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K, Benner C, Heinz S, Bera T, Brenner DA, Kisseleva T. PMID: 28287406; PMCID: PMC5373891.
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    71. Liver inflammation and fibrosis. J Clin Invest. 2017 01 03; 127(1):55-64. Koyama Y, Brenner DA. PMID: 28045404; PMCID: PMC5199698.
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    72. Three distinct cell populations express extracellular matrix proteins and increase in number during skeletal muscle fibrosis. Am J Physiol Cell Physiol. 2017 Feb 01; 312(2):C131-C143. Chapman MA, Mukund K, Subramaniam S, Brenner D, Lieber RL. PMID: 27881411; PMCID: PMC5336596.
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    73. Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood. Hepatology. 2017 01; 65(1):78-88. Decaris ML, Li KW, Emson CL, Gatmaitan M, Liu S, Wang Y, Nyangau E, Colangelo M, Angel TE, Beysen C, Cui J, Hernandez C, Lazaro L, Brenner DA, Turner SM, Hellerstein MK, Loomba R. PMID: 27706836; PMCID: PMC5516243.
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    74. Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. Gastroenterology. 2017 02; 152(3):598-607.e2. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA, Rizo E, Richards L, Brenner D, Sirlin CB, Loomba R. PMID: 27911262; PMCID: PMC5285304.
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    75. Weight Loss Decreases Magnetic Resonance Elastography Estimated Liver Stiffness in Nonalcoholic Fatty Liver Disease. Clin Gastroenterol Hepatol. 2017 03; 15(3):463-464. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K, Richards L, Rizo E, Hernandez C, Kisseleva T, Schnabl B, Brenner D, Sirlin CB, Loomba R. PMID: 27712981; PMCID: PMC5476292.
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    76. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. Differentiation. 2016 Sep; 92(3):84-92. Karin D, Koyama Y, Brenner D, Kisseleva T. PMID: 27591095; PMCID: PMC5079826.
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    77. Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. Age (Dordr). 2016 Aug; 38(4):291-302. Kim IH, Xu J, Liu X, Koyama Y, Ma HY, Diggle K, You YH, Schilling JM, Jeste D, Sharma K, Brenner DA, Kisseleva T. PMID: 27578257; PMCID: PMC5061686.
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    78. Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study. Hepatology. 2016 11; 64(5):1547-1558. Cui J, Chen CH, Lo MT, Schork N, Bettencourt R, Gonzalez MP, Bhatt A, Hooker J, Shaffer K, Nelson KE, Long MT, Brenner DA, Sirlin CB, Loomba R. PMID: 27315352; PMCID: PMC5090982.
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    79. New Developments on the Treatment of Liver Fibrosis. Dig Dis. 2016; 34(5):589-96. Koyama Y, Xu J, Liu X, Brenner DA. PMID: 27332862; PMCID: PMC4961096.
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    80. Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial. J Hepatol. 2016 08; 65(2):369-76. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R, Richards L, Salotti J, Bhatt A, Hooker J, Haufe W, Hooker C, Brenner DA, Sirlin CB, Loomba R. PMID: 27151177; PMCID: PMC5081213.
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    81. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. Am J Gastroenterol. 2016 07; 111(7):986-94. Loomba R, Cui J, Wolfson T, Haufe W, Hooker J, Szeverenyi N, Ang B, Bhatt A, Wang K, Aryafar H, Behling C, Valasek MA, Lin GY, Gamst A, Brenner DA, Yin M, Glaser KJ, Ehman RL, Sirlin CB. PMID: 27002798; PMCID: PMC5001170.
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    82. NEK1 mutations in familial amyotrophic lateral sclerosis. Brain. 2016 05; 139(Pt 5):e28. Brenner D, Müller K, Wieland T, Weydt P, Böhm S, Lulé D, Hübers A, Neuwirth C, Weber M, Borck G, Wahlqvist M, Danzer KM, Volk AE, Meitinger T, Strom TM, Otto M, Kassubek J, Ludolph AC, Andersen PM, Weishaupt JH. PMID: 26945885.
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    83. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. Ma HY, Xu J, Liu X, Zhu Y, Gao B, Karin M, Tsukamoto H, Jeste DV, Grant I, Roberts AJ, Contet C, Geoffroy C, Zheng B, Brenner D, Kisseleva T. PMID: 27239399; PMCID: PMC4878828.
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    84. Promising Therapy Candidates for Liver Fibrosis. Front Physiol. 2016; 7:47. Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH, Brenner DA, Kisseleva T. PMID: 26909046; PMCID: PMC4754444.
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    85. Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. Cell Host Microbe. 2016 Feb 10; 19(2):227-39. Wang L, Fouts DE, Stärkel P, Hartmann P, Chen P, Llorente C, DePew J, Moncera K, Ho SB, Brenner DA, Hooper LV, Schnabl B. PMID: 26867181; PMCID: PMC4786170.
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    86. Liver: DNA methylation controls liver fibrogenesis. Nat Rev Gastroenterol Hepatol. 2016 Mar; 13(3):126-8. Liu X, Brenner DA. PMID: 26860269.
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    87. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Front Physiol. 2016; 7:17. Liang S, Kisseleva T, Brenner DA. PMID: 26869935; PMCID: PMC4735448.
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    89. Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion. J Clin Gastroenterol. 2015 Nov-Dec; 49 Suppl 1:S69-73. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS, Brenner DA, Qamar AA, Miloh TA, Guarino A, Guslandi M, Dieleman LA, Ringel Y, Quigley EM, Brandt LJ. PMID: 26447969.
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    90. Role of Gut Microbiota in Liver Disease. J Clin Gastroenterol. 2015 Nov-Dec; 49 Suppl 1:S25-7. Brenner DA, Paik YH, Schnabl B. PMID: 26447960; PMCID: PMC4602394.
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    91. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Gastroenterology. 2015 Dec; 149(7):1784-93. Loomba R, Schork N, Chen CH, Bettencourt R, Bhatt A, Ang B, Nguyen P, Hernandez C, Richards L, Salotti J, Lin S, Seki E, Nelson KE, Sirlin CB, Brenner D, Genetics of NAFLD in Twins Consortium. PMID: 26299412; PMCID: PMC4663110.
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    92. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. PLoS One. 2015; 10(7):e0129743. Lan T, Kisseleva T, Brenner DA. PMID: 26222337; PMCID: PMC4519306.
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    93. New therapies for hepatic fibrosis. Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S75-9. Koyama Y, Brenner DA. PMID: 26206573; PMCID: PMC4734896.
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    94. Aging and liver disease. Curr Opin Gastroenterol. 2015 May; 31(3):184-91. Kim IH, Kisseleva T, Brenner DA. PMID: 25850346; PMCID: PMC4736713.
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    95. Recent advancement of molecular mechanisms of liver fibrosis. J Hepatobiliary Pancreat Sci. 2015 Jul; 22(7):512-8. Seki E, Brenner DA. PMID: 25869468; PMCID: PMC4668270.
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    96. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. J Exp Med. 2015 Apr 06; 212(4):469-80. Gao L, Brenner D, Llorens-Bobadilla E, Saiz-Castro G, Frank T, Wieghofer P, Hill O, Thiemann M, Karray S, Prinz M, Weishaupt JH, Martin-Villalba A. PMID: 25779632; PMCID: PMC4387281.
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    97. Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). Hepatology. 2015 Apr; 61(4):1239-50. Loomba R, Sirlin CB, Ang B, Bettencourt R, Jain R, Salotti J, Soaft L, Hooker J, Kono Y, Bhatt A, Hernandez L, Nguyen P, Noureddin M, Haufe W, Hooker C, Yin M, Ehman R, Lin GY, Valasek MA, Brenner DA, Richards L, San Diego Integrated NAFLD Research Consortium (SINC). PMID: 25482832; PMCID: PMC4407930.
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    98. Contribution of bone marrow-derived fibrocytes to liver fibrosis. Hepatobiliary Surg Nutr. 2015 Feb; 4(1):34-47. Xu J, Cong M, Park TJ, Scholten D, Brenner DA, Kisseleva T. PMID: 25713803; PMCID: PMC4318956.
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    99. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb; 21(2):159-65. Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M, Evans RM. PMID: 25559344; PMCID: PMC4320010.
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    100. Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice. FASEB J. 2015 Mar; 29(3):1043-55. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA, Miyamoto Y, Eckmann L, Dhungana S, Pathmasiri W, Sumner S, Westwater C, Brenner DA, Schnabl B. PMID: 25466902; PMCID: PMC4422368.
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    101. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. Hepatology. 2014 Dec; 60(6):1920-8. Loomba R, Wolfson T, Ang B, Hooker J, Behling C, Peterson M, Valasek M, Lin G, Brenner D, Gamst A, Ehman R, Sirlin C. PMID: 25103310; PMCID: PMC4245360.
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    102. Agreement between TOAST and CCS ischemic stroke classification: the NINDS SiGN study. Neurology. 2014 Oct 28; 83(18):1653-60. McArdle PF, Kittner SJ, Ay H, Brown RD, Meschia JF, Rundek T, Wassertheil-Smoller S, Woo D, Andsberg G, Biffi A, Brenner DA, Cole JW, Corriveau R, de Bakker PI, Delavaran H, Dichgans M, Grewal RP, Gwinn K, Huq M, Jern C, Jimenez-Conde J, Jood K, Kaplan RC, Katschnig P, Katsnelson M, Labovitz DL, Lemmens R, Li L, Lindgren A, Markus HS, Peddareddygari LR, Pedersén A, Pera J, Redfors P, Roquer J, Rosand J, Rost NS, Rothwell PM, Sacco RL, Sharma P, Slowik A, Sudlow C, Thijs V, Tiedt S, Valenti R, Worrall BB, NINDS SiGN Study. PMID: 25261504; PMCID: PMC4223086.
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    103. New Approaches for Studying Alcoholic Liver Disease. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. Xu J, Liu X, Gao B, Karin M, Tsukamoto H, Brenner D, Kisseleva T. PMID: 26594598; PMCID: PMC4648354.
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    104. Origin of myofibroblasts in the fibrotic liver in mice. Proc Natl Acad Sci U S A. 2014 Aug 12; 111(32):E3297-305. Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA, Hofmann AF, Iida T, Glass CK, Brenner DA, Kisseleva T. PMID: 25074909; PMCID: PMC4136601.
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    105. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. Nat Commun. 2014 Jul 21; 5:4451. Lopez-Sanchez I, Dunkel Y, Roh YS, Mittal Y, De Minicis S, Muranyi A, Singh S, Shanmugam K, Aroonsakool N, Murray F, Ho SB, Seki E, Brenner DA, Ghosh P. PMID: 25043713; PMCID: PMC4107319.
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    106. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014 Aug; 124(8):3566-78. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner DA, Seki E. PMID: 24983318; PMCID: PMC4109552.
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    107. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. J Clin Invest. 2014 Jul; 124(7):2921-34. Moore-Morris T, Guimarães-Camboa N, Banerjee I, Zambon AC, Kisseleva T, Velayoudon A, Stallcup WB, Gu Y, Dalton ND, Cedenilla M, Gomez-Amaro R, Zhou B, Brenner DA, Peterson KL, Chen J, Evans SM. PMID: 24937432; PMCID: PMC4071409.
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    108. Achievement of optimal medical therapy goals for U.S. adults with coronary artery disease: results from the REGARDS Study (REasons for Geographic And Racial Differences in Stroke). J Am Coll Cardiol. 2014 Apr 29; 63(16):1626-33. Brown TM, Voeks JH, Bittner V, Brenner DA, Cushman M, Goff DC, Glasser S, Muntner P, Tabereaux PB, Safford MM. PMID: 24534599; PMCID: PMC4201851.
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    109. Role of NADPH oxidases in liver fibrosis. Antioxid Redox Signal. 2014 Jun 10; 20(17):2854-72. Paik YH, Kim J, Aoyama T, De Minicis S, Bataller R, Brenner DA. PMID: 24040957; PMCID: PMC4026397.
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    110. Transcriptional repression of the transforming growth factor β (TGF-β) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor κB (NF-κB) p50 enhances TGF-β signaling in hepatic stellate cells. J Biol Chem. 2014 Mar 07; 289(10):7082-7091. Liu C, Chen X, Yang L, Kisseleva T, Brenner DA, Seki E. PMID: 24448807; PMCID: PMC3945368.
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    111. Interactions between the intestinal microbiome and liver diseases. Gastroenterology. 2014 May; 146(6):1513-24. Schnabl B, Brenner DA. PMID: 24440671; PMCID: PMC3996054.
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    112. Fra, Fra away: the complex role of activator protein 1 in liver injury. Hepatology. 2014 Jan; 59(1):19-20. Brenner DA. PMID: 23904356.
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    113. Reversibility of liver fibrosis. Gastroenterol Hepatol (N Y). 2013 Nov; 9(11):737-9. Brenner DA. PMID: 24764791; PMCID: PMC3995196.
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    114. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Hepatology. 2013 Dec; 58(6):1930-40. Noureddin M, Lam J, Peterson MR, Middleton M, Hamilton G, Le TA, Bettencourt R, Changchien C, Brenner DA, Sirlin C, Loomba R. PMID: 23696515; PMCID: PMC4819962.
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    115. M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. J Cell Biol. 2013 Sep 16; 202(6):951-66. Madsen DH, Leonard D, Masedunskas A, Moyer A, Jürgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS, Brenner DA, Burgdorf S, Engelholm LH, Behrendt N, Holmbeck K, Weigert R, Bugge TH. PMID: 24019537; PMCID: PMC3776354.
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    116. Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. Curr Pathobiol Rep. 2013 Sep; 1(3):209-214. Liu X, Xu J, Brenner DA, Kisseleva T. PMID: 24000319; PMCID: PMC3757252.
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    117. Semaphorin 7A contributes to TGF-β-mediated liver fibrogenesis. Am J Pathol. 2013 Sep; 183(3):820-30. De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Millán C, Brenner DA, Vivarelli M, Mocchegiani F, Marzioni M, Benedetti A, Svegliati-Baroni G. PMID: 23850082; PMCID: PMC5819760.
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    118. Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships. Gastroenterology. 2013 Jul; 145(1):16-31. Fordtran JS, Goyal RK, Feldman M, Soll AH, Trier JS, Ockner RK, LaRusso NF, Podolsky DK, Brenner DA, Rustgi AK, Omary MB. PMID: 23806784.
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    119. Synergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma. Clin Gastroenterol Hepatol. 2013 Dec; 11(12):1636-45.e1-3. Loomba R, Liu J, Yang HI, Lee MH, Lu SN, Wang LY, Iloeje UH, You SL, Brenner D, Chen CJ, REVEAL–HBV Study Group. PMID: 23669307; PMCID: PMC4100777.
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    120. Serum γ-glutamyltranspeptidase predicts all-cause, cardiovascular and liver mortality in older adults. J Clin Exp Hepatol. 2013 Mar 01; 3(1):4-11. Loomba R, Doycheva I, Bettencourt R, Cohen B, Wassel CL, Brenner D, Barrett-Connor E. PMID: 23997501; PMCID: PMC3940213.
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    121. Kenji Fujiwara, MD, PhD. Gastroenterology. 2013 Apr; 144(4):661-3. Sugano K, Podolsky DK, Brenner DA, Michalopoulos G, Tsukamoto H. PMID: 23499284.
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    122. Overexpression of endoglin modulates TGF-β1-signalling pathways in a novel immortalized mouse hepatic stellate cell line. PLoS One. 2013; 8(2):e56116. Meurer SK, Alsamman M, Sahin H, Wasmuth HE, Kisseleva T, Brenner DA, Trautwein C, Weiskirchen R, Scholten D. PMID: 23437087; PMCID: PMC3577806.
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    123. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Hepatology. 2013 Feb; 57(2):577-89. Miura K, Yang L, van Rooijen N, Brenner DA, Ohnishi H, Seki E. PMID: 22987396; PMCID: PMC3566276.
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    124. Synergism between obesity and alcohol in increasing the risk of hepatocellular carcinoma: a prospective cohort study. Am J Epidemiol. 2013 02 15; 177(4):333-42. Loomba R, Yang HI, Su J, Brenner D, Barrett-Connor E, Iloeje U, Chen CJ. PMID: 23355498; PMCID: PMC3626057.
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    125. Inactivation of myofibroblasts during regression of liver fibrosis. Cell Cycle. 2013 Feb 01; 12(3):381-2. Kisseleva T, Brenner DA. PMID: 23324345; PMCID: PMC3587431.
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    126. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology. 2012 Dec; 56(6):2316-27. Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C, Page P, Brenner DA. PMID: 22806357; PMCID: PMC3493679.
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    127. Liver carcinogenesis: rodent models of hepatocarcinoma and cholangiocarcinoma. Dig Liver Dis. 2013 Jun; 45(6):450-9. De Minicis S, Kisseleva T, Francis H, Baroni GS, Benedetti A, Brenner D, Alvaro D, Alpini G, Marzioni M. PMID: 23177172; PMCID: PMC3716909.
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    128. Next-generation academic medicine. J Clin Invest. 2012 Nov; 122(11):4280-2. Brenner DA. PMID: 23114607; PMCID: PMC3484473.
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    129. Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. Nat Immunol. 2012 Nov; 13(11):1072-82. Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E, Brenner DA, Apte RN, Jung S, Lapidot T. PMID: 22983360.
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    130. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. Gastroenterology. 2012 Nov; 143(5):1330-1340.e1. Hartmann P, Haimerl M, Mazagova M, Brenner DA, Schnabl B. PMID: 22841787; PMCID: PMC3482543.
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    131. Identification of small molecule activators of cryptochrome. Science. 2012 Aug 31; 337(6098):1094-7. Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T, Welsh DK, Brenner DA, Doyle FJ, Schultz PG, Kay SA. PMID: 22798407; PMCID: PMC3589997.
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    132. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Hepatology. 2012 Sep; 56(3):922-32. Le TA, Chen J, Changchien C, Peterson MR, Kono Y, Patton H, Cohen BL, Brenner D, Sirlin C, Loomba R, San Diego Integrated NAFLD Research Consortium (SINC). PMID: 22431131; PMCID: PMC3400720.
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    133. Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis. Gut. 2013 Mar; 62(3):335-6. Schnabl B, Brenner DA. PMID: 22717452; PMCID: PMC4077319.
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    134. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology. 2012 Aug; 143(2):307-20. Seki E, Brenner DA, Karin M. PMID: 22705006; PMCID: PMC3523093.
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    135. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Gastroenterology. 2012 Sep; 143(3):765-776.e3. Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, Österreicher CH, Stickel F, Ley K, Brenner DA, Kisseleva T. PMID: 22687286; PMCID: PMC3635475.
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    136. Origin of myofibroblasts in liver fibrosis. Fibrogenesis Tissue Repair. 2012; 5(Suppl 1):S17. Brenner DA, Kisseleva T, Scholten D, Paik YH, Iwaisako K, Inokuchi S, Schnabl B, Seki E, De Minicis S, Oesterreicher C, Taura K. PMID: 23259769; PMCID: PMC3368775.
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    137. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):9448-53. Kisseleva T, Cong M, Paik Y, Scholten D, Jiang C, Benner C, Iwaisako K, Moore-Morris T, Scott B, Tsukamoto H, Evans SM, Dillmann W, Glass CK, Brenner DA. PMID: 22566629; PMCID: PMC3386114.
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    138. Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist. Proc Natl Acad Sci U S A. 2012 May 22; 109(21):E1369-76. Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y, Sirlin C, Yu E, Yu RT, Downes M, Evans RM, Brenner DA, Schnabl B. PMID: 22538808; PMCID: PMC3361396.
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    139. Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study. PLoS One. 2012; 7(4):e34218. Lee JK, Bettencourt R, Brenner D, Le TA, Barrett-Connor E, Loomba R. PMID: 22514624; PMCID: PMC3325993.
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    140. What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:65-8. Iwaisako K, Brenner DA, Kisseleva T. PMID: 22320919; PMCID: PMC4841268.
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    141. Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease. J Hepatol. 2012 Jun; 56(6):1283-92. Fouts DE, Torralba M, Nelson KE, Brenner DA, Schnabl B. PMID: 22326468; PMCID: PMC3357486.
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    142. Diagnosis and management of patients with α1-antitrypsin (A1AT) deficiency. Clin Gastroenterol Hepatol. 2012 Jun; 10(6):575-80. Nelson DR, Teckman J, Di Bisceglie AM, Brenner DA. PMID: 22200689; PMCID: PMC3360829.
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    143. The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis. J Hepatol. 2012 Apr; 56(4):965-72. Kisseleva T, Brenner DA. PMID: 22173163; PMCID: PMC3307836.
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    144. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. Korean J Hepatol. 2011 Dec; 17(4):251-7. Paik YH, Brenner DA. PMID: 22310788; PMCID: PMC3304665.
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    145. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. Clin Gastroenterol Hepatol. 2012 Mar; 10(3):285-90.e1. Dong MH, Bettencourt R, Brenner DA, Barrett-Connor E, Loomba R. PMID: 22020064; PMCID: PMC3288181.
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    146. Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. Hepatol Res. 2011 Jul; 41(7):683-6. Brenner DA, Seki E, Taura K, Kisseleva T, Deminicis S, Iwaisako K, Inokuchi S, Schnabl B, Oesterreicher CH, Paik YH, Miura K, Kodama Y. PMID: 21711427; PMCID: PMC3341613.
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    147. Migration of fibrocytes in fibrogenic liver injury. Am J Pathol. 2011 Jul; 179(1):189-98. Scholten D, Reichart D, Paik YH, Lindert J, Bhattacharya J, Glass CK, Brenner DA, Kisseleva T. PMID: 21703401; PMCID: PMC3123781.
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    148. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Hepatology. 2011 May; 53(5):1730-41. Paik YH, Iwaisako K, Seki E, Inokuchi S, Schnabl B, Osterreicher CH, Kisseleva T, Brenner DA. PMID: 21384410; PMCID: PMC3082608.
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    149. Is it the end of the line for the EMT? Hepatology. 2011 May; 53(5):1433-5. Kisseleva T, Brenner DA. PMID: 21433040.
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    150. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Liver Int. 2011 Jul; 31(6):762-72. DeLeve LD, Jaeschke H, Kalra VK, Asahina K, Brenner DA, Tsukamoto H. PMID: 21645207; PMCID: PMC4388239.
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    151. Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection. J Mol Med (Berl). 2011 Oct; 89(10):997-1013. Kisseleva T, von Köckritz-Blickwede M, Reichart D, McGillvray SM, Wingender G, Kronenberg M, Glass CK, Nizet V, Brenner DA. PMID: 21499735; PMCID: PMC3171633.
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    152. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol Clin Exp Res. 2011 Aug; 35(8):1509-18. Inokuchi S, Tsukamoto H, Park E, Liu ZX, Brenner DA, Seki E. PMID: 21463341; PMCID: PMC3131439.
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    153. Anti-fibrogenic strategies and the regression of fibrosis. Best Pract Res Clin Gastroenterol. 2011 Apr; 25(2):305-17. Kisseleva T, Brenner DA. PMID: 21497747; PMCID: PMC3086317.
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    154. Alteration of interferon-α/β receptors in chronic hepatitis B patients. J Clin Immunol. 2011 Jun; 31(3):521-32. Meng F, Wang J, Ge J, Fan X, Wang B, Han L, Kisseleva T, Paik Y, Brenner DA, Wang K. PMID: 21445562; PMCID: PMC4795458.
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    155. Innate immunity in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol. 2011 Apr; 300(4):G516-25. Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, Nagy L, Szabo G, Zakhari S. PMID: 21252049; PMCID: PMC3774265.
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    156. Role of toll-like receptors and their downstream molecules in the development of nonalcoholic Fatty liver disease. Gastroenterol Res Pract. 2010; 2010:362847. Miura K, Seki E, Ohnishi H, Brenner DA. PMID: 21274430; PMCID: PMC3026974.
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    157. What goes up must come down: the emerging role of microRNA in fibrosis. Hepatology. 2011 Jan; 53(1):4-6. Chau BN, Brenner DA. PMID: 21254156.
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    158. Mutation of the 5'-untranslated region stem-loop structure inhibits α1(I) collagen expression in vivo. J Biol Chem. 2011 Mar 11; 286(10):8609-8619. Parsons CJ, Stefanovic B, Seki E, Aoyama T, Latour AM, Marzluff WF, Rippe RA, Brenner DA. PMID: 21193410; PMCID: PMC3048743.
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    159. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):308-13. Österreicher CH, Penz-Österreicher M, Grivennikov SI, Guma M, Koltsova EK, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA. PMID: 21173249; PMCID: PMC3017162.
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    160. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. FASEB J. 2011 Apr; 25(4):1133-44. Osawa Y, Seki E, Kodama Y, Suetsugu A, Miura K, Adachi M, Ito H, Shiratori Y, Banno Y, Olefsky JM, Nagaki M, Moriwaki H, Brenner DA, Seishima M. PMID: 21163859; PMCID: PMC3058702.
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    161. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Hepatology. 2011 Jan; 53(1):96-105. Yan AW, Fouts DE, Brandl J, Stärkel P, Torralba M, Schott E, Tsukamoto H, Nelson KE, Brenner DA, Schnabl B. PMID: 21254165; PMCID: PMC3059122.
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    162. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Hepatology. 2010 Oct; 52(4):1420-30. De Minicis S, Seki E, Paik YH, Osterreicher CH, Kodama Y, Kluwe J, Torozzi L, Miyai K, Benedetti A, Schwabe RF, Brenner DA. PMID: 20690191; PMCID: PMC2947612.
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    163. CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. Hepatology. 2010 Oct; 52(4):1390-400. Aoyama T, Inokuchi S, Brenner DA, Seki E. PMID: 20683935; PMCID: PMC2947579.
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    164. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med. 2010 Oct; 16(10):1152-6. Zhang EE, Liu Y, Dentin R, Pongsawakul PY, Liu AC, Hirota T, Nusinow DA, Sun X, Landais S, Kodama Y, Brenner DA, Montminy M, Kay SA. PMID: 20852621; PMCID: PMC2952072.
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    165. Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. Clin Gastroenterol Hepatol. 2010 Oct; 8(10):891-8, 898.e1-2. Loomba R, Yang HI, Su J, Brenner D, Iloeje U, Chen CJ. PMID: 20621202.
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    166. Recent advances in liver stem cell therapy. Curr Opin Gastroenterol. 2010 Jul; 26(4):395-402. Kisseleva T, Gigante E, Brenner DA. PMID: 20495456.
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    167. Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Gastroenterology. 2010 Sep; 139(3):987-98. Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G, Brenner DA, Kisseleva T. PMID: 20546735; PMCID: PMC2930026.
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    168. Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins. Gastroenterology. 2010 Sep; 139(3):836-45, 845.e1. Loomba R, Rao F, Zhang L, Khandrika S, Ziegler MG, Brenner DA, O'Connor DT. PMID: 20537997; PMCID: PMC3038676.
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    169. Awareness, treatment, and control of vascular risk factors among stroke survivors. J Stroke Cerebrovasc Dis. 2010 Jul-Aug; 19(4):311-20. Brenner DA, Zweifler RM, Gomez CR, Kissela BM, Levine D, Howard G, Coull B, Howard VJ. PMID: 20472464; PMCID: PMC3606552.
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    170. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology. 2010 Jul; 139(1):323-34.e7. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H, Olefsky JM, Brenner DA, Seki E. PMID: 20347818; PMCID: PMC4631262.
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    171. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. Hepatology. 2010 Mar; 51(3):942-52. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K, Brenner DA, Ginès P, Bataller R. PMID: 20044807.
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    172. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology. 2010 Mar; 51(3):1027-36. Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M, Brenner DA. PMID: 20052656; PMCID: PMC2906231.
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    173. Hepatic progenitors for liver disease: current position. Stem Cells Cloning. 2010 Feb 25; 3:39-47. Conigliaro A, Brenner DA, Kisseleva T. PMID: 24198509; PMCID: PMC3781731.
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    174. Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. Liver Transpl. 2010 Feb; 16(2):181-90. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA, Brenner DA, Lemasters JJ. PMID: 20104486; PMCID: PMC2834418.
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    175. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):844-9. Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S, Brenner DA, Seki E. PMID: 20080763; PMCID: PMC2818947.
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    176. Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells. Liver Int. 2010 Jan; 30(1):31-41. Sancho-Bru P, Juez E, Moreno M, Khurdayan V, Morales-Ruiz M, Colmenero J, Arroyo V, Brenner DA, Ginès P, Bataller R. PMID: 19929904.
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    177. Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology. 2009 Sep; 50(3):929-38. Osterreicher CH, Taura K, De Minicis S, Seki E, Penz-Osterreicher M, Kodama Y, Kluwe J, Schuster M, Oudit GY, Penninger JM, Brenner DA. PMID: 19650157; PMCID: PMC4734904.
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    178. Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Integr Biol (Camb). 2009 Sep; 1(8-9):513-24. Brafman DA, de Minicis S, Seki E, Shah KD, Teng D, Brenner D, Willert K, Chien S. PMID: 20023766.
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    179. Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Am J Physiol Gastrointest Liver Physiol. 2009 Oct; 297(4):G726-34. Colmenero J, Bataller R, Sancho-Bru P, Domínguez M, Moreno M, Forns X, Bruguera M, Arroyo V, Brenner DA, Ginès P. PMID: 19628656; PMCID: PMC2763804.
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    180. CCR1 and CCR5 promote hepatic fibrosis in mice. J Clin Invest. 2009 Jul; 119(7):1858-70. Seki E, De Minicis S, Gwak GY, Kluwe J, Inokuchi S, Bursill CA, Llovet JM, Brenner DA, Schwabe RF. PMID: 19603542; PMCID: PMC2701864.
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    181. CCR2 promotes hepatic fibrosis in mice. Hepatology. 2009 Jul; 50(1):185-97. Seki E, de Minicis S, Inokuchi S, Taura K, Miyai K, van Rooijen N, Schwabe RF, Brenner DA. PMID: 19441102; PMCID: PMC2705470.
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    182. c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. Gastroenterology. 2009 Oct; 137(4):1467-1477.e5. Kodama Y, Kisseleva T, Iwaisako K, Miura K, Taura K, De Minicis S, Osterreicher CH, Schnabl B, Seki E, Brenner DA. PMID: 19549522; PMCID: PMC2757473.
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    183. Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease. Stroke. 2009 May; 40(5):1721-8. Lavallée PC, Labreuche J, Gongora-Rivera F, Jaramillo A, Brenner D, Klein IF, Touboul PJ, Vicaut E, Amarenco P, Lacunar-BICHAT Investigators. PMID: 19286582.
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    184. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Proc Natl Acad Sci U S A. 2009 Mar 03; 106(9):3300-5. Brandl K, Rutschmann S, Li X, Du X, Xiao N, Schnabl B, Brenner DA, Beutler B. PMID: 19202076; PMCID: PMC2651297.
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    185. The enteropathy of prostaglandin deficiency. J Gastroenterol. 2009; 44 Suppl 19:1-7. Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA, Brenner DA, Milne GL, Morrow JD, Boutaud O, Oates JA. PMID: 19148786; PMCID: PMC2799331.
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    186. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. Gastroenterology. 2009 Apr; 136(4):1423-34. Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y, Brenner DA. PMID: 19249395.
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    187. Molecular pathogenesis of liver fibrosis. Trans Am Clin Climatol Assoc. 2009; 120:361-8. Brenner DA. PMID: 19768189; PMCID: PMC2744540.
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    188. c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps. Hepatology. 2009 Jan; 49(1):6-8. Kodama Y, Brenner DA. PMID: 19111006.
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    189. Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. Hepatology. 2008 Dec; 48(6):2016-26. De Minicis S, Seki E, Oesterreicher C, Schnabl B, Schwabe RF, Brenner DA. PMID: 19025999.
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    190. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol. 2008 Dec; 173(6):1617-27. Lin SL, Kisseleva T, Brenner DA, Duffield JS. PMID: 19008372; PMCID: PMC2626374.
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    191. TNFalpha is required for cholestasis-induced liver fibrosis in the mouse. Biochem Biophys Res Commun. 2009 Jan 16; 378(3):348-53. Gäbele E, Froh M, Arteel GE, Uesugi T, Hellerbrand C, Schölmerich J, Brenner DA, Thurman RG, Rippe RA. PMID: 18996089; PMCID: PMC5052129.
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    192. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Hepatology. 2008 Nov; 48(5):1420-9. Miura K, Taura K, Kodama Y, Schnabl B, Brenner DA. PMID: 18671304.
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    193. NK and NKT cells in liver injury and fibrosis. Clin Immunol. 2009 Jan; 130(1):16-26. Notas G, Kisseleva T, Brenner D. PMID: 18823822.
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    194. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Gastroenterology. 2008 Nov; 135(5):1729-38. Taura K, De Minicis S, Seki E, Hatano E, Iwaisako K, Osterreicher CH, Kodama Y, Miura K, Ikai I, Uemoto S, Brenner DA. PMID: 18823985.
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    195. What is the potential role of antifibrotic agents for the treatment of liver disease? Nat Clin Pract Gastroenterol Hepatol. 2008 Sep; 5(9):496-7. Schnabl B, Scholten D, Brenner DA. PMID: 18628735.
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    196. Toll-like receptors and adaptor molecules in liver disease: update. Hepatology. 2008 Jul; 48(1):322-35. Seki E, Brenner DA. PMID: 18506843.
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    197. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. J Clin Invest. 2008 Jun; 118(6):2121-31. Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA, Brenner DA, Morrow JD, Boutaud O, Oates JA. PMID: 18451993; PMCID: PMC2350426.
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    198. Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. Alcohol. 2008 Aug; 42(5):349-61. Purohit V, Bode JC, Bode C, Brenner DA, Choudhry MA, Hamilton F, Kang YJ, Keshavarzian A, Rao R, Sartor RB, Swanson C, Turner JR. PMID: 18504085; PMCID: PMC2614138.
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    199. The renin-angiotensin-aldosterone system in cerebral small vessel disease. J Neurol. 2008 Jul; 255(7):993-1000. Brenner D, Labreuche J, Pico F, Scheltens P, Poirier O, Cambien F, Amarenco P, GENIC Investigators. PMID: 18446309.
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    200. Fibrogenesis of parenchymal organs. Proc Am Thorac Soc. 2008 Apr 15; 5(3):338-42. Kisseleva T, Brenner DA. PMID: 18403330; PMCID: PMC2645245.
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    201. Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. J Gastroenterol Hepatol. 2008 Mar; 23 Suppl 1:S98-103. De Minicis S, Brenner DA. PMID: 18336675.
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    202. Mechanisms of fibrogenesis. Exp Biol Med (Maywood). 2008 Feb; 233(2):109-22. Kisseleva T, Brenner DA. PMID: 18222966.
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    203. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. Hepatology. 2008 Feb; 47(2):677-85. Adachi M, Brenner DA. PMID: 18220291.
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    204. Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. Hepatology. 2007 Nov; 46(5):1443-52. Mencin A, Seki E, Osawa Y, Kodama Y, De Minicis S, Knowles M, Brenner DA. PMID: 17668872.
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    205. Alzheimer's disease: the vascular connection. Int J Stroke. 2007 Nov; 2(4):243-4. Brenner DA, Alexandrov AV. PMID: 18705924.
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    206. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med. 2007 Nov; 13(11):1324-32. Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, Schwabe RF. PMID: 17952090.
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    207. Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. Gastroenterology. 2007 Dec; 133(6):2019-28. Sancho-Bru P, Bataller R, Fernandez-Varo G, Moreno M, Ramalho LN, Colmenero J, Marí M, Clària J, Jiménez W, Arroyo V, Brenner DA, Ginès P. PMID: 18054572.
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    208. Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB. J Hepatol. 2007 Dec; 47(6):834-43. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y, Brenner DA, Watanabe S. PMID: 17935821.
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    209. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. J Theor Biol. 2007 Dec 07; 249(3):518-31. Sachs RK, Shuryak I, Brenner D, Fakir H, Hlatky L, Hahnfeldt P. PMID: 17897680; PMCID: PMC2169295.
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    210. Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course. J Gastroenterol Hepatol. 2007 Aug; 22(8):1256-64. Tacke F, Trautwein C, Yagmur E, Hellerbrand C, Wiest R, Brenner DA, Schnabl B. PMID: 17688666.
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    211. Nuclear factor-kappaB in the liver: friend or foe? Gastroenterology. 2007 Jun; 132(7):2601-4. Schwabe RF, Brenner DA. PMID: 17570232.
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    212. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. J Gastroenterol Hepatol. 2007 Jun; 22 Suppl 1:S73-8. Kisseleva T, Brenner DA. PMID: 17567473.
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    213. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? J Hepatol. 2007 Aug; 47(2):307-9. Seki E, Brenner DA. PMID: 17566588; PMCID: PMC2739234.
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    214. NOX in liver fibrosis. Arch Biochem Biophys. 2007 Jun 15; 462(2):266-72. De Minicis S, Brenner DA. PMID: 17531188; PMCID: PMC2727549.
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    215. Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force. Gastroenterology. 2007 May; 132(6):2272-5. Kaplan LM, Klein S, Boden G, Brenner DA, Gostout CJ, Lavine JE, Popkin BM, Schirmer BD, Seeley RJ, Yanovski SZ, Cominelli F. PMID: 17498517.
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    216. Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. Dig Dis Sci. 2007 Dec; 52(12):3404-15. Tacke F, Gäbele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C, Brenner DA, Schölmerich J, Schnabl B. PMID: 17415633.
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    217. The genetics of nonalcoholic fatty liver disease. Ann Hepatol. 2007 Apr-Jun; 6(2):83-8. Osterreicher CH, Brenner DA. PMID: 17519829.
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    218. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology. 2007 May; 132(5):1937-46. De Minicis S, Seki E, Uchinami H, Kluwe J, Zhang Y, Brenner DA, Schwabe RF. PMID: 17484886.
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    219. Genomics of liver fibrosis and cirrhosis. Semin Liver Dis. 2007 Feb; 27(1):28-43. Osterreicher CH, Stickel F, Brenner DA. PMID: 17295175.
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    220. The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. Gastroenterology. 2007 Apr; 132(4):1434-46. Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D, Brenner DA. PMID: 17408630.
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    221. Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. Liver Int. 2006 Nov; 26(9):1138-47. Osawa Y, Seki E, Adachi M, Taura K, Kodama Y, Siegmund SV, Schwabe RF, Brenner DA. PMID: 17032415.
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    222. Hepatic stellate cells and the reversal of fibrosis. J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S84-7. Kisseleva T, Brenner DA. PMID: 16958681.
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    223. Immunosuppression, hepatitis B virus variants: Synergistic role in hepatic fibrogenesis. Gastroenterology. 2006 Sep; 131(3):957-60. Paik YH, Brenner DA. PMID: 16952565.
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    224. Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis. Hepatology. 2006 Aug; 44(2):420-9. Uchinami H, Seki E, Brenner DA, D'Armiento J. PMID: 16871591.
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    225. The Clinical Research Forum and Association of American Physicians disagree with criticism of the NIH Roadmap. J Clin Invest. 2006 Aug; 116(8):2058-9. Crowley W, Courtney J, Jameson L, Pardes H, Moskowitz J, Orringer E, Rubenstein A, Wood A, Rettig R, Ausiello D, Brenner D, Collins F, Elias J, Greene W, Horowitz R, Jameson L, Kieff E, Thompson C, Swain JL. PMID: 16886049; PMCID: PMC1523419.
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    226. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. Transplantation. 2006 Jul 27; 82(2):241-50. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H, Brenner DA, Lemasters JJ. PMID: 16858288.
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    227. NADPH oxidase in the liver: defensive, offensive, or fibrogenic? Gastroenterology. 2006 Jul; 131(1):272-5. De Minicis S, Bataller R, Brenner DA. PMID: 16831609.
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    228. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2006 Nov; 291(5):G877-84. Sancho-Bru P, Bataller R, Colmenero J, Gasull X, Moreno M, Arroyo V, Brenner DA, Ginès P. PMID: 16782692.
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    229. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. J Hepatol. 2006 Sep; 45(3):429-38. Kisseleva T, Uchinami H, Feirt N, Quintana-Bustamante O, Segovia JC, Schwabe RF, Brenner DA. PMID: 16846660.
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    230. Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients. Stroke. 2006 Jul; 37(7):1691-6. Brenner D, Labreuche J, Touboul PJ, Schmidt-Petersen K, Poirier O, Perret C, Schönfelder J, Combadière C, Lathrop M, Cambien F, Brand-Herrmann SM, Amarenco P, GENIC Investigators. PMID: 16741188.
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    231. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Gastroenterology. 2006 May; 130(6):1564-72. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N, Seki E, Brenner D, Korenblat K, McCrea J. PMID: 16697719.
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    232. Toll-like receptor signaling in the liver. Gastroenterology. 2006 May; 130(6):1886-900. Schwabe RF, Seki E, Brenner DA. PMID: 16697751.
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    233. The future of gastroenterology and gastroenterology. Gastroenterology. 2006 May; 130(6):1562. Brenner DA. PMID: 16697718.
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    234. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. Lab Invest. 2006 Jul; 86(7):676-86. Paik YH, Lee KS, Lee HJ, Yang KM, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Moon YM, Brenner DA. PMID: 16619004.
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    235. Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation. Am J Physiol Gastrointest Liver Physiol. 2006 Sep; 291(3):G456-63. Lehnert M, Uehara T, Bradford BU, Lind H, Zhong Z, Brenner DA, Marzi I, Lemasters JJ. PMID: 16614372.
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    236. Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol. 2006 Apr; 290(4):G583-9. Schwabe RF, Brenner DA. PMID: 16537970.
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    237. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. Liver Transpl. 2006 Apr; 12(4):550-9. Lehmann TG, Luedde T, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ, Brenner DA. PMID: 16555330.
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    238. Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium. Hepatology. 2006 Apr; 43(4):872-8. Purohit V, Brenner DA. PMID: 16502397.
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    239. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Hepatology. 2005 Dec; 42(6):1320-8. Osawa Y, Hannun YA, Proia RL, Brenner DA. PMID: 16317686.
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    240. Molecular pathogenesis of alcohol-induced hepatic fibrosis. Alcohol Clin Exp Res. 2005 Nov; 29(11 Suppl):102S-109S. Siegmund SV, Brenner DA. PMID: 16344593.
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    241. Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. Biochem Biophys Res Commun. 2005 Sep 16; 335(1):87-96. Schnabl B, Hu K, Mühlbauer M, Hellerbrand C, Stefanovic B, Brenner DA, Schölmerich J. PMID: 16054593.
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    242. Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. Exp Biol Med (Maywood). 2005 Sep; 230(8):573-86. Stefanovic L, Brenner DA, Stefanovic B. PMID: 16118408.
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    243. Liver fibrogenesis: a new role for the renin-angiotensin system. Antioxid Redox Signal. 2005 Sep-Oct; 7(9-10):1346-55. Bataller R, Sancho-Bru P, Ginès P, Brenner DA. PMID: 16115040.
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    244. Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. J Hepatol. 2005 Aug; 43(2):317-23. Yang L, Bataller R, Dulyx J, Coffman TM, Ginès P, Rippe RA, Brenner DA. PMID: 15964094.
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    245. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem. 2005 Jul 29; 280(30):27879-87. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA, Brenner DA. PMID: 15946935.
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    246. NF-kappaB activation in Kupffer cells after partial hepatectomy. Am J Physiol Gastrointest Liver Physiol. 2005 Sep; 289(3):G530-8. Yang L, Magness ST, Bataller R, Rippe RA, Brenner DA. PMID: 15905413.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    247. Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats. Hepatology. 2005 May; 41(5):1046-55. Bataller R, Gäbele E, Parsons CJ, Morris T, Yang L, Schoonhoven R, Brenner DA, Rippe RA. PMID: 15841463.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    248. Anandamide induces necrosis in primary hepatic stellate cells. Hepatology. 2005 May; 41(5):1085-95. Siegmund SV, Uchinami H, Osawa Y, Brenner DA, Schwabe RF. PMID: 15841466.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    249. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. J Biol Chem. 2005 Jun 10; 280(23):21763-72. Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R, Brenner DA, Tabas I. PMID: 15826936.
      View in: PubMed   Mentions: 170     Fields:    Translation:AnimalsCells
    250. JNK mediates hepatic ischemia reperfusion injury. J Hepatol. 2005 Jun; 42(6):850-9. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK, Brenner DA. PMID: 15885356.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    251. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J Clin Invest. 2005 Apr; 115(4):849-59. Luedde T, Assmus U, Wüstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K, Brenner DA, Manns MP, Pasparakis M, Trautwein C. PMID: 15776110; PMCID: PMC1064982.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    252. Information assimilation and distribution challenges and goals for real and virtual journals. J Clin Gastroenterol. 2005 Mar; 39(3):181-8. Modlin IM, Adler G, Alexander K, Arnold R, Brenner DA, Corazziari E, Floch MH, LaPorte RE, Peterson WL, Quigley EM, Shapiro MD, Spechler SJ, Spiller RC, Tytgat GN, Wiegers W. PMID: 15718859.
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    253. Liver fibrosis. J Clin Invest. 2005 Feb; 115(2):209-18. Bataller R, Brenner DA. PMID: 15690074; PMCID: PMC546435.
      View in: PubMed   Mentions: 1499     Fields:    Translation:HumansAnimals
    254. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. J Biol Chem. 2005 Apr 08; 280(14):13374-82. Gäbele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW, Brenner DA, Rippe RA. PMID: 15677443.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    255. Clinical syndromes of alcoholic liver disease. Dig Dis. 2005; 23(3-4):255-63. Adachi M, Brenner DA. PMID: 16508290.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    256. Molecular mechanisms of alcohol-induced hepatic fibrosis. Dig Dis. 2005; 23(3-4):264-74. Siegmund SV, Dooley S, Brenner DA. PMID: 16508291.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    257. Data from arrays: an embarrassment of riches. Gastroenterology. 2004 Dec; 127(6):1659. Brenner DA. PMID: 15578500.
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    258. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Hepatology. 2004 Nov; 40(5):1106-15. Parsons CJ, Bradford BU, Pan CQ, Cheung E, Schauer M, Knorr A, Krebs B, Kraft S, Zahn S, Brocks B, Feirt N, Mei B, Cho MS, Ramamoorthi R, Roldan G, Ng P, Lum P, Hirth-Dietrich C, Tomkinson A, Brenner DA. PMID: 15389776.
      View in: PubMed   Mentions: 55     Fields:    Translation:Animals
    259. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Hepatology. 2004 Nov; 40(5):1151-9. Magness ST, Bataller R, Yang L, Brenner DA. PMID: 15389867.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    260. Akt activation protects rat liver from ischemia/reperfusion injury. J Surg Res. 2004 Oct; 121(2):159-70. Harada N, Hatano E, Koizumi N, Nitta T, Yoshida M, Yamamoto N, Brenner DA, Yamaoka Y. PMID: 15501455.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    261. From quiescence to activation: Gene regulation in hepatic stellate cells. Gastroenterology. 2004 Oct; 127(4):1260-2. Rippe RA, Brenner DA. PMID: 15481004.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    262. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Transplantation. 2004 Aug 15; 78(3):324-32. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R, Brenner DA, Lemasters J. PMID: 15316358.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    263. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. J Immunol. 2004 Aug 01; 173(3):1561-70. Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE, Brenner DA, Jobin C. PMID: 15265883.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    264. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. J Hepatol. 2004 Jun; 40(6):942-51. Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ, Brenner DA, Rippe RA, Behrns KE. PMID: 15158334.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    265. TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein. Surgery. 2004 Jun; 135(6):619-28. Black D, Bird MA, Hayden M, Schrum LW, Lange P, Samson C, Hatano E, Rippe RA, Brenner DA, Behrns KE. PMID: 15179368.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    266. Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region. J Biol Chem. 2004 May 28; 279(22):23822-9. Lindquist JN, Parsons CJ, Stefanovic B, Brenner DA. PMID: 14973140.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    267. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. FASEB J. 2004 Apr; 18(6):720-2. Schwabe RF, Uchinami H, Qian T, Bennett BL, Lemasters JJ, Brenner DA. PMID: 14766793.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    268. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology. 2004 Feb; 126(2):529-40. Bataller R, Paik YH, Lindquist JN, Lemasters JJ, Brenner DA. PMID: 14762790.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    269. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Mol Cell Biol. 2004 Feb; 24(4):1758-68. Stefanovic B, Stefanovic L, Schnabl B, Bataller R, Brenner DA. PMID: 14749390; PMCID: PMC344171.
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    270. Gastrointestinal basic science 2002-2003: the year in review. Clin Gastroenterol Hepatol. 2004 Jan; 2(1):9-13. Brenner DA. PMID: 15017626.
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    271. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest. 2003 Nov; 112(9):1383-94. Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ, Brenner DA. PMID: 14597764; PMCID: PMC228420.
      View in: PubMed   Mentions: 173     Fields:    Translation:HumansAnimalsCells
    272. MELD and the practicing gastroenterologist. Gastroenterology. 2003 Oct; 125(4):1009. Brown RS, Brenner DA. PMID: 14517781.
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    273. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. Liver Int. 2003 Oct; 23(5):386-96. Imose M, Nagaki M, Naiki T, Osawa Y, Brenner DA, Asano T, Hayashi H, Kato T, Moriwaki H. PMID: 14708901.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    274. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. Transplantation. 2003 Jul 15; 76(1):28-37. Lehmann TG, Wheeler MD, Froh M, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ, Brenner DA, Thurman RG. PMID: 12865782.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    275. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. J Hepatol. 2003 Jul; 39(1):38-46. Kweon YO, Paik YH, Schnabl B, Qian T, Lemasters JJ, Brenner DA. PMID: 12821042.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    276. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. Am J Physiol Gastrointest Liver Physiol. 2003 Nov; 285(5):G949-58. Schwabe RF, Bataller R, Brenner DA. PMID: 12829440.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansCells
    277. Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver. Am J Physiol Gastrointest Liver Physiol. 2003 Sep; 285(3):G642-51. Bataller R, Gäbele E, Schoonhoven R, Morris T, Lehnert M, Yang L, Brenner DA, Rippe RA. PMID: 12773299.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    278. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology. 2003 May; 37(5):1043-55. Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C, Brenner DA. PMID: 12717385.
      View in: PubMed   Mentions: 234     Fields:    Translation:HumansAnimalsCells
    279. Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition. Toxicol Sci. 2003 May; 73(1):44-52. Oh KW, Qian T, Brenner DA, Lemasters JJ. PMID: 12700412.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    280. Expression of the NF-kappa B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activation. J Immunol. 2003 Apr 15; 170(8):4053-60. Osawa Y, Nagaki M, Banno Y, Brenner DA, Nozawa Y, Moriwaki H, Nakashima S. PMID: 12682234.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    281. Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. J Hepatol. 2003 Apr; 38(4):468-75. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T, Brenner DA, Yamaoka Y. PMID: 12663239.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    282. Hepatitis C and alcohol: fundamental and translational research directions. Alcohol Clin Exp Res. 2003 Apr; 27(4):726-31. Morgan TR, Brenner D, Everhart J, French SW, Fried MW, Gretch DR, Koziel MJ, McClain CJ, Peters MG, Weinman SA, Lucas DL. PMID: 12711937.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    283. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Hepatology. 2003 Apr; 37(4):833-41. Luedde T, Rodriguez ME, Tacke F, Xiong Y, Brenner DA, Trautwein C. PMID: 12668976.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    284. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology. 2003 Apr; 37(4):824-32. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R, Brenner DA. PMID: 12668975.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    285. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. Hepatology. 2003 Mar; 37(3):653-64. Schnabl B, Purbeck CA, Choi YH, Hagedorn CH, Brenner D. PMID: 12601363.
      View in: PubMed   Mentions: 59     Fields:    Translation:Humans
    286. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. Hepatology. 2003 Mar; 37(3):493-503. Bataller R, North KE, Brenner DA. PMID: 12601343.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimals
    287. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Hepatology. 2003 Feb; 37(2):267-76. Yata Y, Scanga A, Gillan A, Yang L, Reif S, Breindl M, Brenner DA, Rippe RA. PMID: 12540776.
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    288. Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat. Gastroenterology. 2003 Feb; 124(2):445-58. Iimuro Y, Nishio T, Morimoto T, Nitta T, Stefanovic B, Choi SK, Brenner DA, Yamaoka Y. PMID: 12557150.
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    289. Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. Front Biosci. 2003 Jan 01; 8:d69-77. Gäbele E, Brenner DA, Rippe RA. PMID: 12456323.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    290. The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression. J Biol Chem. 2003 Mar 07; 278(10):8083-90. Reif S, Lang A, Lindquist JN, Yata Y, Gabele E, Scanga A, Brenner DA, Rippe RA. PMID: 12502711.
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    291. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. Hepatology. 2002 Dec; 36(6):1498-508. Kim YS, Schwabe RF, Qian T, Lemasters JJ, Brenner DA. PMID: 12447876.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    292. Tumor necrosis factor alpha-induced interleukin-8 production via NF-kappaB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes. Infect Immun. 2002 Nov; 70(11):6294-301. Osawa Y, Nagaki M, Banno Y, Brenner DA, Asano T, Nozawa Y, Moriwaki H, Nakashima S. PMID: 12379708; PMCID: PMC130316.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    293. Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. Antioxid Redox Signal. 2002 Oct; 4(5):769-81. Lemasters JJ, Qian T, He L, Kim JS, Elmore SP, Cascio WE, Brenner DA. PMID: 12470504.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    294. Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism. Surgery. 2002 Sep; 132(3):441-9. Samson CM, Schrum LW, Bird MA, Lange PA, Brenner DA, Rippe RA, Behrns KE. PMID: 12324757.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    295. Joint statement on missions and submissions of papers to AGA journals. Gastroenterology. 2002 Sep; 123(3):877-8. Brenner DA, Camilleri M. PMID: 12198713.
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    296. An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. Blood. 2002 Aug 15; 100(4):1470-7. Magness ST, Maeda N, Brenner DA. PMID: 12149233.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    297. Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. Hepatology. 2002 Aug; 36(2):315-25. Liedtke C, Plümpe J, Kubicka S, Bradham CA, Manns MP, Brenner DA, Trautwein C. PMID: 12143039.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    298. Differential requirement for NF-kappaB-inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas. Am J Physiol Cell Physiol. 2002 Jul; 283(1):C347-57. Russo MP, Bennett BL, Manning AM, Brenner DA, Jobin C. PMID: 12055104.
      View in: PubMed   Mentions: 6  Translation:HumansCells
    299. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2002 Jul; 283(1):G204-11. Schwabe RF, Brenner DA. PMID: 12065308.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    300. Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy. J Biol Chem. 2002 May 17; 277(20):18229-37. Stefanovic B, Schnabl B, Brenner DA. PMID: 11889120.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    301. Immortal activated human hepatic stellate cells generated by ectopic telomerase expression. Lab Invest. 2002 Mar; 82(3):323-33. Schnabl B, Choi YH, Olsen JC, Hagedorn CH, Brenner DA. PMID: 11896211.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    302. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. J Gastroenterol Hepatol. 1998 Sep; 13(S1):S39-S50. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, Connor HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT, Brenner D, Kadiiska M, Mason RP. PMID: 28976690.
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