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Jehad Almaliti

Title(s)Visiting Associate Researcher, Center for Marine Biotechnology and Biomedecine
SchoolVc-marine Sciences
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A recombinant expression system for the Plasmodium falciparum proteasome enables structural analysis of its assembly and the design of selective inhibitors. bioRxiv. 2025 Sep 09. Fajtova P, Zhang H, Urich L, da Silva EB, da Silva CH, Almaliti J, Al-Hindy M, Boura E, Kirkman LA, Lin G, Bogyo M, Fidock DA, Gerwick WH, Zhao J, O'Donoghue AJ. PMID: 40832278; PMCID: PMC12363949.
      View in: PubMed   Mentions:
    2. Development of Macrocyclic Peptide-Based Proteasome Inhibitors with Enhanced Blood-Brain Barrier Penetration for Treating Brain Neoplasms. J Med Chem. 2025 Sep 25; 68(18):18908-18929. Almaliti J, Al-Hindy M, Fajtová P, Glukhov E, Berger T, Graf Y, Hoffmann da Silva CE, Huang C, Azizyan N, He Y, O'Donoghue AJ, Gerwick WH. PMID: 40922058.
      View in: PubMed   Mentions:    Fields:    
    3. Cyanobacteria Join the Kahalalide Conversation: Genome and Metabolite Evidence for Structurally Related Peptides. J Am Chem Soc. 2025 Sep 03; 147(35):31800-31810. Ryu B, Avalon NE, Cuau M, Almaliti J, Din MO, Brennan C, Glukhov E, Knight R, Gerwick L, Gerwick WH. PMID: 40828982; PMCID: PMC12449831.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    4. Neutral pH-Selective Inhibition of Cytosolic Cathepsin B: A Novel Drug Targeting Strategy for Traumatic Brain Injury and Alzheimer's Disease. ACS Chem Biol. 2025 Aug 15; 20(8):1841-1848. Hook V, Podvin S, Yoon MC, Phan VV, Florio J, Spencer B, Mosier C, Cheng A, Ahuett S, Almaliti J, Gerwick WH, Rissman RA, O'Donoghue AJ. PMID: 40700403; PMCID: PMC12362428.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Activation of Cytosolic Cathepsin B Activity in the Brain by Traumatic Brain Injury and Inhibition by the Neutral pH Selective Inhibitor Probe Z-Arg-Lys-AOMK. ACS Chem Neurosci. 2025 Apr 02; 16(7):1297-1308. Podvin S, Florio J, Spencer B, Mante M, Guzman E, Arias C, Mosier C, Phan VV, Yoon MC, Almaliti J, O'Donoghue AJ, Gerwick WH, Rissman RA, Hook V. PMID: 40130579; PMCID: PMC11969537.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. Exploring the Anticancer Effect of Artemisia herba-alba on Colorectal Cancer: Insights From Eight Colorectal Cancer Cell Lines. Food Sci Nutr. 2025 Jan; 13(1):e4715. Bou Malhab LJ, Harb AA, Eldohaji L, Taneera J, Al-Hroub HM, Abuhelwa A, Alzoubi KH, Abu-Irmaileh B, Hudaib M, Almaliti J, Abdel-Rahman WM, Shanableh A, Semreen MH, El-Huneidi W, Abu-Gharbieh E, Bustanji Y. PMID: 39803277; PMCID: PMC11717013.
      View in: PubMed   Mentions: 1  
    7. Distinct substrate specificities of the three catalytic subunits of the Trichomonas vaginalis proteasome. Protein Sci. 2024 Dec; 33(12):e5225. Fajtova P, Hurysz BM, Miyamoto Y, Serafim MSM, Jiang Z, Vazquez JM, Trujillo DF, Liu LJ, Somani U, Almaliti J, Myers SA, Caffrey CR, Gerwick WH, McMinn DL, Kirk CJ, Boura E, Eckmann L, O'Donoghue AJ. PMID: 39589076; PMCID: PMC11590128.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    8. Carmaphycin B-Based Proteasome Inhibitors to Treat Human African Trypanosomiasis: Structure-Activity Relationship and In Vivo Efficacy. ACS Infect Dis. 2024 Dec 13; 10(12):4182-4193. Liu LJ, Francisco KR, Sun YU, Serafim MSM, Amarasinghe DK, Teixeira TR, Lucero B, Kronenberger T, Elsayed W, Elwakeel H, Al-Hindy M, Almaliti J, Gerwick WH, O'Donoghue AJ, Caffrey CR. PMID: 39589805; PMCID: PMC11650654.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    9. Evaluating Antimalarial Proteasome Inhibitors for Efficacy in Babesia Blood Stage Cultures. ACS Omega. 2024 Nov 12; 9(45):44989-44999. Robbertse L, Fajtová P, Šnebergerová P, Jalovecká M, Levytska V, Barbosa da Silva E, Sharma V, Pachl P, Almaliti J, Al-Hindy M, Gerwick WH, Boura E, O'Donoghue AJ, Sojka D. PMID: 39554424; PMCID: PMC11561622.
      View in: PubMed   Mentions: 4  
    10. Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors. Nat Commun. 2024 10 04; 15(1):8621. Silhan J, Fajtova P, Bartosova J, Hurysz BM, Almaliti J, Miyamoto Y, Eckmann L, Gerwick WH, O'Donoghue AJ, Boura E. PMID: 39366995; PMCID: PMC11452676.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    11. Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis. ACS Infect Dis. 2024 Jun 14; 10(6):1935-1948. Spiwoková P, Horn M, Fanfrlík J, Jílková A, Fajtová P, Leontovyc A, Houštecká R, Bieliková L, Brynda J, Chanová M, Mertlíková-Kaiserová H, Caro-Diaz EJE, Almaliti J, El-Sakkary N, Gerwick WH, Caffrey CR, Mareš M. PMID: 38757505; PMCID: PMC11184554.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    12. Orthogonal Deprotection Strategy of Fmoc Provides Improved Synthesis of Sensitive Peptides: Application to Z-Arg-Lys-AOMK. ACS Omega. 2024 Jan 23; 9(3):3997-4003. Almaliti J, Alhindy M, Yoon MC, Hook V, Molinski TF, O'Donoghue AJ, Gerwick WH. PMID: 38284081; PMCID: PMC10809369.
      View in: PubMed   Mentions: 1  
    13. Covalent Macrocyclic Proteasome Inhibitors Mitigate Resistance in Plasmodium falciparum. ACS Infect Dis. 2023 10 13; 9(10):2036-2047. Bennett JM, Ward KE, Muir RK, Kabeche S, Yoo E, Yeo T, Lam G, Zhang H, Almaliti J, Berger G, Faucher FF, Lin G, Gerwick WH, Yeh E, Fidock DA, Bogyo M. PMID: 37712594; PMCID: PMC10591878.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    14. Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors. bioRxiv. 2023 Aug 17. Silhan J, Fajtova P, Bartosova J, Hurysz BM, Almaliti J, Miyamoto Y, Eckmann L, Gerwick WH, O'Donoghue AJ, Boura E. PMID: 37645851; PMCID: PMC10462138.
      View in: PubMed   Mentions:
    15. Metabolomics Approaches for the Diagnosis, Treatment, and Better Disease Management of Viral Infections. Metabolites. 2023 Aug 15; 13(8). Al-Sulaiti H, Almaliti J, Naman CB, Al Thani AA, Yassine HM. PMID: 37623891; PMCID: PMC10456346.
      View in: PubMed   Mentions: 13  
    16. Methods in marine natural product drug discovery: what's new? Expert Opin Drug Discov. 2023 07; 18(7):687-691. Almaliti J, Gerwick WH. PMID: 37194298.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Secondary Metabolites Profiling, Antimicrobial and Cytotoxic Properties of Commiphora gileadensis L. Leaves, Seeds, Callus, and Cell Suspension Extracts. Metabolites. 2023 Apr 10; 13(4). Al-Abdallat AM, Adayileh BK, Sawwan JS, Shibli R, Al-Qudah TS, Abu-Irmaileh B, Albdaiwi RN, Almaliti J, Bustanji Y. PMID: 37110196; PMCID: PMC10146941.
      View in: PubMed   Mentions: 2  
    18. Development of subunit selective substrates for Trichomonas vaginalis proteasome. bioRxiv. 2023 Apr 06. Fajtova P, Hurysz BM, Miyamoto Y, Serafim M, Jiang Z, Trujillo DF, Liu L, Somani U, Almaliti J, Myers SA, Caffrey CR, Gerwick WH, Kirk CJ, Boura E, Eckmann L, O'Donoghue AJ. PMID: 37066163; PMCID: PMC10104049.
      View in: PubMed   Mentions:
    19. Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome. Cell Chem Biol. 2023 05 18; 30(5):470-485.e6. Deni I, Stokes BH, Ward KE, Fairhurst KJ, Pasaje CFA, Yeo T, Akbar S, Park H, Muir R, Bick DS, Zhan W, Zhang H, Liu YJ, Ng CL, Kirkman LA, Almaliti J, Gould AE, Duffey M, O'Donoghue AJ, Uhlemann AC, Niles JC, da Fonseca PCA, Gerwick WH, Lin G, Bogyo M, Fidock DA. PMID: 36963402; PMCID: PMC10198959.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    20. Development of Potent and Highly Selective Epoxyketone-Based Plasmodium Proteasome Inhibitors. Chemistry. 2023 Apr 06; 29(20):e202203958. Almaliti J, Fajtová P, Calla J, LaMonte GM, Feng M, Rocamora F, Ottilie S, Glukhov E, Boura E, Suhandynata RT, Momper JD, Gilson MK, Winzeler EA, Gerwick WH, O'Donoghue AJ. PMID: 36617500; PMCID: PMC10894724.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    21. Discovery of Novel Epoxyketone Peptides as Lipase Inhibitors. Molecules. 2022 Mar 31; 27(7). Almaliti J, Alzweiri M, Alhindy M, Al-Helo T, Daoud I, Deknash R, Naman CB, Abu-Irmaileh B, Bustanji Y, Hamad I. PMID: 35408660; PMCID: PMC9000415.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    22. Portobelamides A and B and Caciqueamide, Cytotoxic Peptidic Natural Products from a Caldora sp. Marine Cyanobacterium. J Nat Prod. 2021 08 27; 84(8):2081-2093. Demirkiran O, Almaliti J, Leão T, Navarro G, Byrum T, Valeriote FA, Gerwick L, Gerwick WH. PMID: 34269583.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    23. Applying a Chemogeographic Strategy for Natural Product Discovery from the Marine Cyanobacterium Moorena bouillonii. Mar Drugs. 2020 Oct 14; 18(10). Leber CA, Naman CB, Keller L, Almaliti J, Caro-Diaz EJE, Glukhov E, Joseph V, Sajeevan TP, Reyes AJ, Biggs JS, Li T, Yuan Y, He S, Yan X, Gerwick WH. PMID: 33066480; PMCID: PMC7602127.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    24. Tutuilamides A-C: Vinyl-Chloride-Containing Cyclodepsipeptides from Marine Cyanobacteria with Potent Elastase Inhibitory Properties. ACS Chem Biol. 2020 03 20; 15(3):751-757. Keller L, Canuto KM, Liu C, Suzuki BM, Almaliti J, Sikandar A, Naman CB, Glukhov E, Luo D, Duggan BM, Luesch H, Koehnke J, O'Donoghue AJ, Gerwick WH. PMID: 31935054; PMCID: PMC7480958.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    25. Design and Synthesis of New Sulfonamides-Based Flt3 Inhibitors. Med Chem. 2020; 16(3):403-412. Abutayeh RF, Almaliti J, Taha MO. PMID: 30931863.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    26. 20S Proteasome as a Drug Target in Trichomonas vaginalis. Antimicrob Agents Chemother. 2019 11; 63(11). O'Donoghue AJ, Bibo-Verdugo B, Miyamoto Y, Wang SC, Yang JZ, Zuill DE, Matsuka S, Jiang Z, Almaliti J, Caffrey CR, Gerwick WH, Eckmann L. PMID: 31451503; PMCID: PMC6811414.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    27. Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain. J Med Chem. 2019 10 24; 62(20):9026-9044. Boudreau PD, Miller BW, McCall LI, Almaliti J, Reher R, Hirata K, Le T, Siqueira-Neto JL, Hook V, Gerwick WH. PMID: 31539239; PMCID: PMC7240701.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    28. The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni. ACS Infect Dis. 2019 10 11; 5(10):1802-1812. Bibo-Verdugo B, Wang SC, Almaliti J, Ta AP, Jiang Z, Wong DA, Lietz CB, Suzuki BM, El-Sakkary N, Hook V, Salvesen GS, Gerwick WH, Caffrey CR, O'Donoghue AJ. PMID: 31355632; PMCID: PMC7283364.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    29. Untargeted mass spectrometry-based metabolomics approach unveils molecular changes in raw and processed foods and beverages. Food Chem. 2020 Jan 01; 302:125290. Gauglitz JM, Aceves CM, Aksenov AA, Aleti G, Almaliti J, Bouslimani A, Brown EA, Campeau A, Caraballo-Rodríguez AM, Chaar R, da Silva RR, Demko AM, Di Ottavio F, Elijah E, Ernst M, Ferguson LP, Holmes X, Jarmusch AK, Jiang L, Kang KB, Koester I, Kwan B, Li J, Li Y, Melnik AV, Molina-Santiago C, Ni B, Oom AL, Panitchpakdi MW, Petras D, Quinn R, Sikora N, Spengler K, Teke B, Tripathi A, Ul-Hasan S, van der Hooft JJJ, Vargas F, Vrbanac A, Vu AQ, Wang SC, Weldon K, Wilson K, Wozniak JM, Yoon M, Bandeira N, Dorrestein PC. PMID: 31404873.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    30. Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents. Eur J Med Chem. 2019 Jan 01; 161:416-432. Almaliti J, Miller B, Pietraszkiewicz H, Glukhov E, Naman CB, Kline T, Hanson J, Li X, Zhou S, Valeriote FA, Gerwick WH. PMID: 30384045; PMCID: PMC6248884.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    31. Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species. J Nat Prod. 2017 08 25; 80(8):2328-2334. Naman CB, Almaliti J, Armstrong L, Caro-Díaz EJ, Pierce ML, Glukhov E, Fenner A, Spadafora C, Debonsi HM, Dorrestein PC, Murray TF, Gerwick WH. PMID: 28783331.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    32. Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity. J Med Chem. 2017 08 10; 60(15):6721-6732. LaMonte GM, Almaliti J, Bibo-Verdugo B, Keller L, Zou BY, Yang J, Antonova-Koch Y, Orjuela-Sanchez P, Boyle CA, Vigil E, Wang L, Goldgof GM, Gerwick L, O'Donoghue AJ, Winzeler EA, Gerwick WH, Ottilie S. PMID: 28696697; PMCID: PMC5554889.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    33. Dudawalamides A-D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens. J Nat Prod. 2017 06 23; 80(6):1827-1836. Almaliti J, Malloy KL, Glukhov E, Spadafora C, Gutiérrez M, Gerwick WH. PMID: 28535042.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    34. Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue. J Med Chem. 2016 12 08; 59(23):10642-10660. Almaliti J, Al-Hamashi AA, Negmeldin AT, Hanigan CL, Perera L, Pflum MK, Casero RA, Tillekeratne LM. PMID: 27809521; PMCID: PMC5574184.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    35. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nat Biotechnol. 2016 08 09; 34(8):828-837. Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, P CAB, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJN, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AMC, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BO, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein PC, Bandeira N. PMID: 27504778; PMCID: PMC5321674.
      View in: PubMed   Mentions: 1876     Fields:    
    36. Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel. Cell Chem Biol. 2016 05 19; 23(5):561-566. Paatero AO, Kellosalo J, Dunyak BM, Almaliti J, Gestwicki JE, Gerwick WH, Taunton J, Paavilainen VO. PMID: 27203376.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    37. Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria. J Nat Prod. 2015 Jul 24; 78(7):1671-82. Kleigrewe K, Almaliti J, Tian IY, Kinnel RB, Korobeynikov A, Monroe EA, Duggan BM, Di Marzo V, Sherman DH, Dorrestein PC, Gerwick L, Gerwick WH. PMID: 26149623; PMCID: PMC4681511.
      View in: PubMed   Mentions: 72     Fields:    Translation:Cells
    38. Natural products inspired synthesis of neuroprotective agents against H₂O₂-induced cell death. Bioorg Med Chem Lett. 2013 Mar 01; 23(5):1232-7. Almaliti J, Nada SE, Carter B, Shah ZA, Tillekeratne LM. PMID: 23380377.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
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