Jehad Almaliti

Title(s)	Visiting Associate Researcher, Center for Marine Biotechnology and Biomedecine
School	Vc-marine Sciences
Address	9500 Gilman Drive # La Jolla CA 92093
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Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Orthogonal Deprotection Strategy of Fmoc Provides Improved Synthesis of Sensitive Peptides: Application to Z-Arg-Lys-AOMK. ACS Omega. 2024 Jan 23; 9(3):3997-4003. Almaliti J, Alhindy M, Yoon MC, Hook V, Molinski TF, O'Donoghue AJ, Gerwick WH. PMID: 38284081; PMCID: PMC10809369.

View in: PubMed Mentions:
Covalent Macrocyclic Proteasome Inhibitors Mitigate Resistance in Plasmodium falciparum. ACS Infect Dis. 2023 Oct 13; 9(10):2036-2047. Bennett JM, Ward KE, Muir RK, Kabeche S, Yoo E, Yeo T, Lam G, Zhang H, Almaliti J, Berger G, Faucher FF, Lin G, Gerwick WH, Yeh E, Fidock DA, Bogyo M. PMID: 37712594; PMCID: PMC10591878.

View in: PubMed Mentions: Fields:
Ant Anti-Infective Agents Dru Drug Therapy Mic Microbiology
Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors. bioRxiv. 2023 Aug 17. Silhan J, Fajtova P, Bartosova J, Hurysz BM, Almaliti J, Miyamoto Y, Eckmann L, Gerwick WH, O'Donoghue AJ, Boura E. PMID: 37645851; PMCID: PMC10462138.

View in: PubMed Mentions:
Metabolomics Approaches for the Diagnosis, Treatment, and Better Disease Management of Viral Infections. Metabolites. 2023 Aug 15; 13(8). Al-Sulaiti H, Almaliti J, Naman CB, Al Thani AA, Yassine HM. PMID: 37623891; PMCID: PMC10456346.

View in: PubMed Mentions: 2
Methods in marine natural product drug discovery: what's new? Expert Opin Drug Discov. 2023 07; 18(7):687-691. Almaliti J, Gerwick WH. PMID: 37194298.

View in: PubMed Mentions: 1 Fields:
Che Chemistry Techniques Pha Pharmacology
Translation:Humans
Secondary Metabolites Profiling, Antimicrobial and Cytotoxic Properties of Commiphora gileadensis L. Leaves, Seeds, Callus, and Cell Suspension Extracts. Metabolites. 2023 Apr 10; 13(4). Al-Abdallat AM, Adayileh BK, Sawwan JS, Shibli R, Al-Qudah TS, Abu-Irmaileh B, Albdaiwi RN, Almaliti J, Bustanji Y. PMID: 37110196; PMCID: PMC10146941.

View in: PubMed Mentions: 1
Development of subunit selective substrates for Trichomonas vaginalis proteasome. bioRxiv. 2023 Apr 06. Fajtova P, Hurysz BM, Miyamoto Y, Serafim M, Jiang Z, Trujillo DF, Liu L, Somani U, Almaliti J, Myers SA, Caffrey CR, Gerwick WH, Kirk CJ, Boura E, Eckmann L, O'Donoghue AJ. PMID: 37066163; PMCID: PMC10104049.

View in: PubMed Mentions:
Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome. Cell Chem Biol. 2023 05 18; 30(5):470-485.e6. Deni I, Stokes BH, Ward KE, Fairhurst KJ, Pasaje CFA, Yeo T, Akbar S, Park H, Muir R, Bick DS, Zhan W, Zhang H, Liu YJ, Ng CL, Kirkman LA, Almaliti J, Gould AE, Duffey M, O'Donoghue AJ, Uhlemann AC, Niles JC, da Fonseca PCA, Gerwick WH, Lin G, Bogyo M, Fidock DA. PMID: 36963402; PMCID: PMC10198959.

View in: PubMed Mentions: 5 Fields:
Bio Biochemistry Bio Biology Che Chemistry
Translation:Humans Animals
Development of Potent and Highly Selective Epoxyketone-Based Plasmodium Proteasome Inhibitors. Chemistry. 2023 Apr 06; 29(20):e202203958. Almaliti J, Fajtová P, Calla J, LaMonte GM, Feng M, Rocamora F, Ottilie S, Glukhov E, Boura E, Suhandynata RT, Momper JD, Gilson MK, Winzeler EA, Gerwick WH, O'Donoghue AJ. PMID: 36617500; PMCID: PMC10894724.

View in: PubMed Mentions: 2 Fields:
Che Chemistry
Translation:Humans Animals
Discovery of Novel Epoxyketone Peptides as Lipase Inhibitors. Molecules. 2022 Mar 31; 27(7). Almaliti J, Alzweiri M, Alhindy M, Al-Helo T, Daoud I, Deknash R, Naman CB, Abu-Irmaileh B, Bustanji Y, Hamad I. PMID: 35408660; PMCID: PMC9000415.

View in: PubMed Mentions: 1 Fields:
Bio Biology
Translation:Humans
Portobelamides A and B and Caciqueamide, Cytotoxic Peptidic Natural Products from a Caldora sp. Marine Cyanobacterium. J Nat Prod. 2021 08 27; 84(8):2081-2093. Demirkiran O, Almaliti J, Leão T, Navarro G, Byrum T, Valeriote FA, Gerwick L, Gerwick WH. PMID: 34269583.

View in: PubMed Mentions: 1 Fields:
Pha Pharmacology
Translation:Humans Cells
Applying a Chemogeographic Strategy for Natural Product Discovery from the Marine Cyanobacterium Moorena bouillonii. Mar Drugs. 2020 Oct 14; 18(10). Leber CA, Naman CB, Keller L, Almaliti J, Caro-Diaz EJE, Glukhov E, Joseph V, Sajeevan TP, Reyes AJ, Biggs JS, Li T, Yuan Y, He S, Yan X, Gerwick WH. PMID: 33066480; PMCID: PMC7602127.

View in: PubMed Mentions: 4 Fields:
Bio Biology Pha Pharmacology
Translation:Humans Animals Cells
Tutuilamides A-C: Vinyl-Chloride-Containing Cyclodepsipeptides from Marine Cyanobacteria with Potent Elastase Inhibitory Properties. ACS Chem Biol. 2020 03 20; 15(3):751-757. Keller L, Canuto KM, Liu C, Suzuki BM, Almaliti J, Sikandar A, Naman CB, Glukhov E, Luo D, Duggan BM, Luesch H, Koehnke J, O'Donoghue AJ, Gerwick WH. PMID: 31935054; PMCID: PMC7480958.

View in: PubMed Mentions: 20 Fields:
Bio Biochemistry Bio Biology
Translation:Humans Cells
Design and Synthesis of New Sulfonamides-Based Flt3 Inhibitors. Med Chem. 2020; 16(3):403-412. Abutayeh RF, Almaliti J, Taha MO. PMID: 30931863.

View in: PubMed Mentions: Fields:
Che Chemistry
Translation:Humans Cells
20S Proteasome as a Drug Target in Trichomonas vaginalis. Antimicrob Agents Chemother. 2019 11; 63(11). O'Donoghue AJ, Bibo-Verdugo B, Miyamoto Y, Wang SC, Yang JZ, Zuill DE, Matsuka S, Jiang Z, Almaliti J, Caffrey CR, Gerwick WH, Eckmann L. PMID: 31451503; PMCID: PMC6811414.

View in: PubMed Mentions: 11 Fields:
Ant Anti-Infective Agents
Translation:Humans Animals Cells
Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain. J Med Chem. 2019 10 24; 62(20):9026-9044. Boudreau PD, Miller BW, McCall LI, Almaliti J, Reher R, Hirata K, Le T, Siqueira-Neto JL, Hook V, Gerwick WH. PMID: 31539239; PMCID: PMC7240701.

View in: PubMed Mentions: 17 Fields:
Che Chemistry
Translation:Humans Animals
The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni. ACS Infect Dis. 2019 10 11; 5(10):1802-1812. Bibo-Verdugo B, Wang SC, Almaliti J, Ta AP, Jiang Z, Wong DA, Lietz CB, Suzuki BM, El-Sakkary N, Hook V, Salvesen GS, Gerwick WH, Caffrey CR, O'Donoghue AJ. PMID: 31355632; PMCID: PMC7283364.

View in: PubMed Mentions: 14 Fields:
Ant Anti-Infective Agents Dru Drug Therapy Mic Microbiology
Translation:Humans Animals Cells
Untargeted mass spectrometry-based metabolomics approach unveils molecular changes in raw and processed foods and beverages. Food Chem. 2020 Jan 01; 302:125290. Gauglitz JM, Aceves CM, Aksenov AA, Aleti G, Almaliti J, Bouslimani A, Brown EA, Campeau A, Caraballo-Rodríguez AM, Chaar R, da Silva RR, Demko AM, Di Ottavio F, Elijah E, Ernst M, Ferguson LP, Holmes X, Jarmusch AK, Jiang L, Kang KB, Koester I, Kwan B, Li J, Li Y, Melnik AV, Molina-Santiago C, Ni B, Oom AL, Panitchpakdi MW, Petras D, Quinn R, Sikora N, Spengler K, Teke B, Tripathi A, Ul-Hasan S, van der Hooft JJJ, Vargas F, Vrbanac A, Vu AQ, Wang SC, Weldon K, Wilson K, Wozniak JM, Yoon M, Bandeira N, Dorrestein PC. PMID: 31404873.

View in: PubMed Mentions: 17 Fields:
Che Chemistry Nut Nutritional Sciences
Translation:Cells
Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents. Eur J Med Chem. 2019 Jan 01; 161:416-432. Almaliti J, Miller B, Pietraszkiewicz H, Glukhov E, Naman CB, Kline T, Hanson J, Li X, Zhou S, Valeriote FA, Gerwick WH. PMID: 30384045; PMCID: PMC6248884.

View in: PubMed Mentions: 13 Fields:
Che Chemistry
Translation:Humans Cells
Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species. J Nat Prod. 2017 08 25; 80(8):2328-2334. Naman CB, Almaliti J, Armstrong L, Caro-Díaz EJ, Pierce ML, Glukhov E, Fenner A, Spadafora C, Debonsi HM, Dorrestein PC, Murray TF, Gerwick WH. PMID: 28783331.

View in: PubMed Mentions: 7 Fields:
Pha Pharmacology
Translation:Humans Cells
Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity. J Med Chem. 2017 08 10; 60(15):6721-6732. LaMonte GM, Almaliti J, Bibo-Verdugo B, Keller L, Zou BY, Yang J, Antonova-Koch Y, Orjuela-Sanchez P, Boyle CA, Vigil E, Wang L, Goldgof GM, Gerwick L, O'Donoghue AJ, Winzeler EA, Gerwick WH, Ottilie S. PMID: 28696697; PMCID: PMC5554889.

View in: PubMed Mentions: 42 Fields:
Che Chemistry
Translation:Humans Animals Cells
Dudawalamides A-D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens. J Nat Prod. 2017 06 23; 80(6):1827-1836. Almaliti J, Malloy KL, Glukhov E, Spadafora C, Gutiérrez M, Gerwick WH. PMID: 28535042.

View in: PubMed Mentions: 11 Fields:
Pha Pharmacology
Translation:Animals Cells
Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue. J Med Chem. 2016 12 08; 59(23):10642-10660. Almaliti J, Al-Hamashi AA, Negmeldin AT, Hanigan CL, Perera L, Pflum MK, Casero RA, Tillekeratne LM. PMID: 27809521; PMCID: PMC5574184.

View in: PubMed Mentions: 7 Fields:
Che Chemistry
Translation:Humans Cells
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nat Biotechnol. 2016 08 09; 34(8):828-837. Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, P CAB, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJN, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AMC, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BO, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein PC, Bandeira N. PMID: 27504778; PMCID: PMC5321674.

View in: PubMed Mentions: 1343 Fields:
Bio Biotechnology
Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel. Cell Chem Biol. 2016 05 19; 23(5):561-566. Paatero AO, Kellosalo J, Dunyak BM, Almaliti J, Gestwicki JE, Gerwick WH, Taunton J, Paavilainen VO. PMID: 27203376.

View in: PubMed Mentions: 49 Fields:
Bio Biochemistry Bio Biology Che Chemistry
Translation:Humans Cells
Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria. J Nat Prod. 2015 Jul 24; 78(7):1671-82. Kleigrewe K, Almaliti J, Tian IY, Kinnel RB, Korobeynikov A, Monroe EA, Duggan BM, Di Marzo V, Sherman DH, Dorrestein PC, Gerwick L, Gerwick WH. PMID: 26149623; PMCID: PMC4681511.

View in: PubMed Mentions: 65 Fields:
Pha Pharmacology
Translation:Cells
Natural products inspired synthesis of neuroprotective agents against H₂O₂-induced cell death. Bioorg Med Chem Lett. 2013 Mar 01; 23(5):1232-7. Almaliti J, Nada SE, Carter B, Shah ZA, Tillekeratne LM. PMID: 23380377.

View in: PubMed Mentions: 5 Fields:
Bio Biochemistry Che Chemistry
Translation:Cells