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Steven Gonias

Title(s)Professor, Pathology
SchoolHealth Sciences
Phone858-534-0455
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    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Inflammation by the Fibrinolytic System
    NIH/NHLBI R01HL136395Apr 10, 2017 - Mar 31, 2021
    Role: Principal Investigator
    Schwann Cell NMDA Receptor in PNS Injury
    NIH/NINDS R01NS097590Feb 1, 2017 - Jan 31, 2021
    Role: Principal Investigator
    Targeting the Urokinase Receptor in Glioblastoma Multiforme
    NIH/NCI R01CA169096Mar 1, 2013 - Feb 28, 2018
    Role: Principal Investigator
    Alpha2-macroglobulin in peripheral nerve injury
    NIH/NINDS R01NS054671Jul 1, 2007 - Jun 30, 2013
    Role: Principal Investigator
    Gordon Research Conference 2006 Plasminogen Activation
    NIH/NHLBI R13HL083676Sep 30, 2005 - Aug 31, 2006
    Role: Principal Investigator
    Urokinase Receptor-initiated Cell-signaling
    NIH/NCI R01CA094900Apr 1, 2002 - Aug 31, 2012
    Role: Principal Investigator
    Regulation of Signaling Receptor Activity by LRP-1
    NIH/NHLBI R01HL060551Aug 1, 1999 - Dec 31, 2014
    Role: Principal Investigator
    Regulation of Growth Factor Activity by A2 Macroglobulin
    NIH/NCI R01CA053462Aug 1, 1992 - May 31, 2007
    Role: Principal Investigator
    ENVIRONMENTAL MODULATION OF FIBRINOLYSIS INHIBITORS
    NIH/NHLBI R01HL045786Sep 30, 1990 - Jul 31, 1994
    Role: Principal Investigator
    PROTEINASE IN FIBRINOLYSIS AND THROMBOLYTIC THERAPY
    NIH/NHLBI K04HL002272Jul 1, 1989 - Jun 30, 1994
    Role: Principal Investigator
    University of Virginia Cancer Center Support Grant
    NIH P30CA044579Jul 1, 1987 - Jan 31, 2022
    Role: Co-Investigator
    Medical Scientist Training Program
    NIH/NIGMS T32GM007267Jul 1, 1977 - Jun 30, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Gonias SL. Hepatocyte tPA: where have you been hiding? Blood. 2019 Feb 14; 133(7):631-632. PMID: 30765497.
      View in: PubMed
    2. Brifault C, Kwon H, Campana WM, Gonias SL. LRP1 deficiency in microglia blocks neuro-inflammation in the spinal dorsal horn and neuropathic pain processing. Glia. 2019 Feb 11. PMID: 30746765.
      View in: PubMed
    3. Zalfa C, Azmoon P, Mantuano E, Gonias SL. Tissue-type plasminogen activator neutralizes LPS but not protease-activated receptor-mediated inflammatory responses to plasmin. J Leukoc Biol. 2019 Jan 28. PMID: 30690783.
      View in: PubMed
    4. Gonias SL. Mechanisms by Which LRP1 (Low-Density Lipoprotein Receptor-Related Protein-1) Maintains Arterial Integrity. Arterioscler Thromb Vasc Biol. 2018 Nov; 38(11):2548-2549. PMID: 30354248.
      View in: PubMed
    5. Gonias SL, Banki MA, Gilder AS, Azmoon P, Campana WM, Mantuano E. PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology. J Cell Sci. 2018 Jul 26; 131(14). PMID: 29930084.
      View in: PubMed
    6. Poplawski G, Ishikawa T, Brifault C, Lee-Kubli C, Regestam R, Henry KW, Shiga Y, Kwon H, Ohtori S, Gonias SL, Campana WM. Schwann cells regulate sensory neuron gene expression before and after peripheral nerve injury. Glia. 2018 Mar 09. PMID: 29520865.
      View in: PubMed
    7. Gilder AS, Natali L, Van Dyk DM, Zalfa C, Banki MA, Pizzo DP, Wang H, Klemke RL, Mantuano E, Gonias SL. The Urokinase Receptor Induces a Mesenchymal Gene Expression Signature in Glioblastoma Cells and Promotes Tumor Cell Survival in Neurospheres. Sci Rep. 2018 Feb 14; 8(1):2982. PMID: 29445239.
      View in: PubMed
    8. Gonias SL, Karimi-Mostowfi N, Murray SS, Mantuano E, Gilder AS. Expression of LDL receptor-related proteins (LRPs) in common solid malignancies correlates with patient survival. PLoS One. 2017; 12(10):e0186649. PMID: 29088295.
      View in: PubMed
    9. Brifault C, Gilder AS, Laudati E, Banki M, Gonias SL. Shedding of membrane-associated LDL receptor-related protein-1 from microglia amplifies and sustains neuroinflammation. J Biol Chem. 2017 11 10; 292(45):18699-18712. PMID: 28972143.
      View in: PubMed
    10. Mantuano E, Azmoon P, Brifault C, Banki MA, Gilder AS, Campana WM, Gonias SL. Tissue-type plasminogen activator regulates macrophage activation and innate immunity. Blood. 2017 09 14; 130(11):1364-1374. PMID: 28684538.
      View in: PubMed
    11. Campana WM, Mantuano E, Azmoon P, Henry K, Banki MA, Kim JH, Pizzo DP, Gonias SL. Ionotropic glutamate receptors activate cell signaling in response to glutamate in Schwann cells. FASEB J. 2017 04; 31(4):1744-1755. PMID: 28073836.
      View in: PubMed
    12. Gilder AS, Wang L, Natali L, Karimi-Mostowfi N, Brifault C, Gonias SL. Pertussis Toxin Is a Robust and Selective Inhibitor of High Grade Glioma Cell Migration and Invasion. PLoS One. 2016; 11(12):e0168418. PMID: 27977780.
      View in: PubMed
    13. Flütsch A, Henry K, Mantuano E, Lam MS, Shibayama M, Takahashi K, Gonias SL, Campana WM. Evidence that LDL receptor-related protein 1 acts as an early injury detection receptor and activates c-Jun in Schwann cells. Neuroreport. 2016 12 14; 27(18):1305-1311. PMID: 27824728.
      View in: PubMed
    14. Hau AM, Leivo MZ, Gilder AS, Hu JJ, Gonias SL, Hansel DE. mTORC2 activation is regulated by the urokinase receptor (uPAR) in bladder cancer. Cell Signal. 2017 01; 29:96-106. PMID: 27777073.
      View in: PubMed
    15. Laudati E, Gilder AS, Lam MS, Misasi R, Sorice M, Gonias SL, Mantuano E. The activities of LDL Receptor-related Protein-1 (LRP1) compartmentalize into distinct plasma membrane microdomains. Mol Cell Neurosci. 2016 10; 76:42-51. PMID: 27565578.
      View in: PubMed
    16. Mantuano E, Brifault C, Lam MS, Azmoon P, Gilder AS, Gonias SL. LDL receptor-related protein-1 regulates NF?B and microRNA-155 in macrophages to control the inflammatory response. Proc Natl Acad Sci U S A. 2016 Feb 02; 113(5):1369-74. PMID: 26787872; PMCID: PMC4747752.
    17. Jones KA, Gilder AS, Lam MS, Du N, Banki MA, Merati A, Pizzo DP, VandenBerg SR, Gonias SL. Selective coexpression of VEGF receptor 2 in EGFRvIII-positive glioblastoma cells prevents cellular senescence and contributes to their aggressive nature. Neuro Oncol. 2016 05; 18(5):667-78. PMID: 26420897; PMCID: PMC4827039 [Available on 05/01/17].
    18. Mantuano E, Lam MS, Shibayama M, Campana WM, Gonias SL. The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration. J Cell Sci. 2015 Sep 15; 128(18):3478-88. PMID: 26272917; PMCID: PMC4594737.
    19. Gonias SL, Hu J. Urokinase receptor and resistance to targeted anticancer agents. Front Pharmacol. 2015; 6:154. PMID: 26283964; PMCID: PMC4515545.
    20. Gilder AS, Jones KA, Hu J, Wang L, Chen CC, Carter BS, Gonias SL. Soluble Urokinase Receptor Is Released Selectively by Glioblastoma Cells That Express Epidermal Growth Factor Receptor Variant III and Promotes Tumor Cell Migration and Invasion. J Biol Chem. 2015 Jun 12; 290(24):14798-809. PMID: 25837250; PMCID: PMC4463428.
    21. Wykosky J, Hu J, Gomez GG, Taylor T, Villa GR, Pizzo D, VandenBerg SR, Thorne AH, Chen CC, Mischel PS, Gonias SL, Cavenee WK, Furnari FB. A urokinase receptor-Bim signaling axis emerges during EGFR inhibitor resistance in mutant EGFR glioblastoma. Cancer Res. 2015 Jan 15; 75(2):394-404. PMID: 25432173; PMCID: PMC4297573.
    22. Hu J, Muller KA, Furnari FB, Cavenee WK, VandenBerg SR, Gonias SL. Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling. Oncogene. 2015 Jul 30; 34(31):4078-88. PMID: 25347738; PMCID: PMC4411189.
    23. Hu J, Jo M, Eastman BM, Gilder AS, Bui JD, Gonias SL. uPAR induces expression of transforming growth factor ß and interleukin-4 in cancer cells to promote tumor-permissive conditioning of macrophages. Am J Pathol. 2014 Dec; 184(12):3384-93. PMID: 25310970; PMCID: PMC4258500.
    24. Pasillas MP, Shields S, Reilly R, Strnadel J, Behl C, Park R, Yates JR, Klemke R, Gonias SL, Coppinger JA. Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation. Mol Cell Proteomics. 2015 Jan; 14(1):1-14. PMID: 24997994; PMCID: PMC4288246.
    25. Demeule M, Beaudet N, Régina A, Besserer-Offroy É, Murza A, Tétreault P, Belleville K, Ché C, Larocque A, Thiot C, Béliveau R, Longpré JM, Marsault É, Leduc R, Lachowicz JE, Gonias SL, Castaigne JP, Sarret P. Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties. J Clin Invest. 2014 Mar; 124(3):1199-213. PMID: 24531547; PMCID: PMC3934173.
    26. Gupta S, Hau AM, Beach JR, Harwalker J, Mantuano E, Gonias SL, Egelhoff TT, Hansel DE. Mammalian target of rapamycin complex 2 (mTORC2) is a critical determinant of bladder cancer invasion. PLoS One. 2013; 8(11):e81081. PMID: 24312263; PMCID: PMC3842329.
    27. Mantuano E, Lam MS, Gonias SL. LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein. J Biol Chem. 2013 Nov 22; 288(47):34009-18. PMID: 24129569; PMCID: PMC3837140.
    28. Gonias SL, Campana WM. LDL receptor-related protein-1: a regulator of inflammation in atherosclerosis, cancer, and injury to the nervous system. Am J Pathol. 2014 Jan; 184(1):18-27. PMID: 24128688; PMCID: PMC3873482.
    29. Staudt ND, Jo M, Hu J, Bristow JM, Pizzo DP, Gaultier A, VandenBerg SR, Gonias SL. Myeloid cell receptor LRP1/CD91 regulates monocyte recruitment and angiogenesis in tumors. Cancer Res. 2013 Jul 01; 73(13):3902-12. PMID: 23633492; PMCID: PMC3702673.
    30. Orita S, Henry K, Mantuano E, Yamauchi K, De Corato A, Ishikawa T, Feltri ML, Wrabetz L, Gaultier A, Pollack M, Ellisman M, Takahashi K, Gonias SL, Campana WM. Schwann cell LRP1 regulates remak bundle ultrastructure and axonal interactions to prevent neuropathic pain. J Neurosci. 2013 Mar 27; 33(13):5590-602. PMID: 23536074; PMCID: PMC3837698.
    31. Fernandez-Castaneda A, Arandjelovic S, Stiles TL, Schlobach RK, Mowen KA, Gonias SL, Gaultier A. Identification of the low density lipoprotein (LDL) receptor-related protein-1 interactome in central nervous system myelin suggests a role in the clearance of necrotic cell debris. J Biol Chem. 2013 Feb 15; 288(7):4538-48. PMID: 23264627; PMCID: PMC3576060.
    32. Stiles TL, Dickendesher TL, Gaultier A, Fernandez-Castaneda A, Mantuano E, Giger RJ, Gonias SL. LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin. J Cell Sci. 2013 Jan 01; 126(Pt 1):209-20. PMID: 23132925; PMCID: PMC3603516.
    33. Bristow JM, Reno TA, Jo M, Gonias SL, Klemke RL. Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover. J Biol Chem. 2013 Jan 04; 288(1):123-31. PMID: 23105102; PMCID: PMC3537006.
    34. Eastman BM, Jo M, Webb DL, Takimoto S, Gonias SL. A transformation in the mechanism by which the urokinase receptor signals provides a selection advantage for estrogen receptor-expressing breast cancer cells in the absence of estrogen. Cell Signal. 2012 Sep; 24(9):1847-55. PMID: 22617030; PMCID: PMC3383391.
    35. Mantuano E, Henry K, Yamauchi T, Hiramatsu N, Yamauchi K, Orita S, Takahashi K, Lin JH, Gonias SL, Campana WM. The unfolded protein response is a major mechanism by which LRP1 regulates Schwann cell survival after injury. J Neurosci. 2011 Sep 21; 31(38):13376-85. PMID: 21940431; PMCID: PMC3188465.
    36. Hu J, Jo M, Cavenee WK, Furnari F, VandenBerg SR, Gonias SL. Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15984-9. PMID: 21896743; PMCID: PMC3179096.
    37. Endsley MP, Hu Y, Deng Y, He X, Warejcka DJ, Twining SS, Gonias SL, Zhang M. Maspin, the molecular bridge between the plasminogen activator system and beta1 integrin that facilitates cell adhesion. J Biol Chem. 2011 Jul 15; 286(28):24599-607. PMID: 21606500; PMCID: PMC3137035.
    38. Shi Y, Yamauchi T, Gaultier A, Takimoto S, Campana WM, Gonias SL. Regulation of cytokine expression by Schwann cells in response to a2-macroglobulin binding to LRP1. J Neurosci Res. 2011 Apr; 89(4):544-51. PMID: 21290408; PMCID: PMC3560970.
    39. Gonias SL, Gaultier A, Jo M. Regulation of the urokinase receptor (uPAR) by LDL receptor-related protein-1 (LRP1). Curr Pharm Des. 2011; 17(19):1962-9. PMID: 21711236.
      View in: PubMed
    40. Gaultier A, Simon G, Niessen S, Dix M, Takimoto S, Cravatt BF, Gonias SL. LDL receptor-related protein 1 regulates the abundance of diverse cell-signaling proteins in the plasma membrane proteome. J Proteome Res. 2010 Dec 03; 9(12):6689-95. PMID: 20919742; PMCID: PMC2997161.
    41. Jo M, Eastman BM, Webb DL, Stoletov K, Klemke R, Gonias SL. Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells. Cancer Res. 2010 Nov 01; 70(21):8948-58. PMID: 20940399; PMCID: PMC2970644.
    42. Gorovoy M, Gaultier A, Campana WM, Firestein GS, Gonias SL. Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages. J Leukoc Biol. 2010 Oct; 88(4):769-78. PMID: 20610799; PMCID: PMC2974427.
    43. Gonias SL. Factor XII bridges coagulation and fibrinolysis again. Blood. 2010 Jun 17; 115(24):4979-80. PMID: 20558624.
      View in: PubMed
    44. Mantuano E, Jo M, Gonias SL, Campana WM. Low density lipoprotein receptor-related protein (LRP1) regulates Rac1 and RhoA reciprocally to control Schwann cell adhesion and migration. J Biol Chem. 2010 May 07; 285(19):14259-66. PMID: 20197276; PMCID: PMC2863187.
    45. Green CE, Liu T, Montel V, Hsiao G, Lester RD, Subramaniam S, Gonias SL, Klemke RL. Chemoattractant signaling between tumor cells and macrophages regulates cancer cell migration, metastasis and neovascularization. PLoS One. 2009 Aug 21; 4(8):e6713. PMID: 19696929; PMCID: PMC2725301.
    46. Gaultier A, Hollister M, Reynolds I, Hsieh EH, Gonias SL. LRP1 regulates remodeling of the extracellular matrix by fibroblasts. Matrix Biol. 2010 Jan; 29(1):22-30. PMID: 19699300; PMCID: PMC2818094.
    47. Jo M, Lester RD, Montel V, Eastman B, Takimoto S, Gonias SL. Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling. J Biol Chem. 2009 Aug 21; 284(34):22825-33. PMID: 19546228.
      View in: PubMed
    48. Jo M, Takimoto S, Montel V, Gonias SL. The urokinase receptor promotes cancer metastasis independently of urokinase-type plasminogen activator in mice. Am J Pathol. 2009 Jul; 175(1):190-200. PMID: 19497996; PMCID: PMC2708805.
    49. Shi Y, Mantuano E, Inoue G, Campana WM, Gonias SL. Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway. Sci Signal. 2009 Apr 28; 2(68):ra18. PMID: 19401592; PMCID: PMC2696635.
    50. Gaultier A, Wu X, Le Moan N, Takimoto S, Mukandala G, Akassoglou K, Campana WM, Gonias SL. Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis. J Cell Sci. 2009 Apr 15; 122(Pt 8):1155-62. PMID: 19299462; PMCID: PMC2714439.
    51. Mantuano E, Inoue G, Li X, Takahashi K, Gaultier A, Gonias SL, Campana WM. The hemopexin domain of matrix metalloproteinase-9 activates cell signaling and promotes migration of schwann cells by binding to low-density lipoprotein receptor-related protein. J Neurosci. 2008 Nov 05; 28(45):11571-82. PMID: 18987193; PMCID: PMC3837707.
    52. Galliano MF, Toulza E, Jonca N, Gonias SL, Serre G, Guerrin M. Binding of alpha2ML1 to the low density lipoprotein receptor-related protein 1 (LRP1) reveals a new role for LRP1 in the human epidermis. PLoS One. 2008 Jul 23; 3(7):e2729. PMID: 18648652; PMCID: PMC2453322.
    53. Gonias SL. Urokinase: the identity crisis continues. Blood. 2008 Jul 01; 112(1):8. PMID: 18574039.
      View in: PubMed
    54. Mantuano E, Mukandala G, Li X, Campana WM, Gonias SL. Molecular dissection of the human alpha2-macroglobulin subunit reveals domains with antagonistic activities in cell signaling. J Biol Chem. 2008 Jul 18; 283(29):19904-11. PMID: 18499670; PMCID: PMC2459272.
    55. Gaultier A, Arandjelovic S, Niessen S, Overton CD, Linton MF, Fazio S, Campana WM, Cravatt BF, Gonias SL. Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor. Blood. 2008 Jun 01; 111(11):5316-25. PMID: 18369152; PMCID: PMC2396725.
    56. Gaultier A, Arandjelovic S, Li X, Janes J, Dragojlovic N, Zhou GP, Dolkas J, Myers RR, Gonias SL, Campana WM. A shed form of LDL receptor-related protein-1 regulates peripheral nerve injury and neuropathic pain in rodents. J Clin Invest. 2008 Jan; 118(1):161-72. PMID: 18060043; PMCID: PMC2104478.
    57. Stoletov K, Montel V, Lester RD, Gonias SL, Klemke R. High-resolution imaging of the dynamic tumor cell vascular interface in transparent zebrafish. Proc Natl Acad Sci U S A. 2007 Oct 30; 104(44):17406-11. PMID: 17954920; PMCID: PMC2077269.
    58. Montel V, Gaultier A, Lester RD, Campana WM, Gonias SL. The low-density lipoprotein receptor-related protein regulates cancer cell survival and metastasis development. Cancer Res. 2007 Oct 15; 67(20):9817-24. PMID: 17942912.
      View in: PubMed
    59. Wu X, Li ZF, Brooks R, Komives EA, Torpey JW, Engvall E, Gonias SL, Shelton GD. Autoantibodies in canine masticatory muscle myositis recognize a novel myosin binding protein-C family member. J Immunol. 2007 Oct 01; 179(7):4939-44. PMID: 17878394.
      View in: PubMed
    60. Arandjelovic S, Dragojlovic N, Li X, Myers RR, Campana WM, Gonias SL. A derivative of the plasma protease inhibitor alpha(2)-macroglobulin regulates the response to peripheral nerve injury. J Neurochem. 2007 Oct; 103(2):694-705. PMID: 17725582.
      View in: PubMed
    61. Lester RD, Jo M, Montel V, Takimoto S, Gonias SL. uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells. J Cell Biol. 2007 Jul 30; 178(3):425-36. PMID: 17664334; PMCID: PMC2064849.
    62. Luo JL, Tan W, Ricono JM, Korchynskyi O, Zhang M, Gonias SL, Cheresh DA, Karin M. Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature. 2007 Apr 05; 446(7136):690-4. PMID: 17377533.
      View in: PubMed
    63. Campana WM, Li X, Dragojlovic N, Janes J, Gaultier A, Gonias SL. The low-density lipoprotein receptor-related protein is a pro-survival receptor in Schwann cells: possible implications in peripheral nerve injury. J Neurosci. 2006 Oct 25; 26(43):11197-207. PMID: 17065459.
      View in: PubMed
    64. Jo M, Thomas KS, Takimoto S, Gaultier A, Hsieh EH, Lester RD, Gonias SL. Urokinase receptor primes cells to proliferate in response to epidermal growth factor. Oncogene. 2007 Apr 19; 26(18):2585-94. PMID: 17043637.
      View in: PubMed
    65. Arandjelovic S, Van Sant CL, Gonias SL. Limited mutations in full-length tetrameric human alpha2-macroglobulin abrogate binding of platelet-derived growth factor-BB and transforming growth factor-beta1. J Biol Chem. 2006 Jun 23; 281(25):17061-8. PMID: 16641085.
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    66. Gaultier A, Salicioni AM, Arandjelovic S, Gonias SL. Regulation of the composition of the extracellular matrix by low density lipoprotein receptor-related protein-1: activities based on regulation of mRNA expression. J Biol Chem. 2006 Mar 17; 281(11):7332-40. PMID: 16407289.
      View in: PubMed
    67. Wu L, Gonias SL. The low-density lipoprotein receptor-related protein-1 associates transiently with lipid rafts. J Cell Biochem. 2005 Dec 01; 96(5):1021-33. PMID: 16149055.
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    68. Hu K, Yang J, Tanaka S, Gonias SL, Mars WM, Liu Y. Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression. J Biol Chem. 2006 Jan 27; 281(4):2120-7. PMID: 16303771.
      View in: PubMed
    69. Lester RD, Jo M, Campana WM, Gonias SL. Erythropoietin promotes MCF-7 breast cancer cell migration by an ERK/mitogen-activated protein kinase-dependent pathway and is primarily responsible for the increase in migration observed in hypoxia. J Biol Chem. 2005 Nov 25; 280(47):39273-7. PMID: 16207704.
      View in: PubMed
    70. Li X, Gonias SL, Campana WM. Schwann cells express erythropoietin receptor and represent a major target for Epo in peripheral nerve injury. Glia. 2005 Sep; 51(4):254-65. PMID: 15812815.
      View in: PubMed
    71. Mars WM, Jo M, Gonias SL. Activation of hepatocyte growth factor by urokinase-type plasminogen activator is ionic strength-dependent. Biochem J. 2005 Aug 15; 390(Pt 1):311-5. PMID: 15869463; PMCID: PMC1184584.
    72. Arandjelovic S, Hall BD, Gonias SL. Mutation of lysine 1370 in full-length human alpha2-macroglobulin blocks binding to the low density lipoprotein receptor-related protein-1. Arch Biochem Biophys. 2005 Jun 01; 438(1):29-35. PMID: 15910735.
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    73. Mettenburg JM, Arandjelovic S, Gonias SL. A chemically modified preparation of alpha2-macroglobulin binds beta-amyloid peptide with increased affinity and inhibits Abeta cytotoxicity. J Neurochem. 2005 Apr; 93(1):53-62. PMID: 15773905.
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    74. Jo M, Thomas KS, Marozkina N, Amin TJ, Silva CM, Parsons SJ, Gonias SL. Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator. J Biol Chem. 2005 Apr 29; 280(17):17449-57. PMID: 15728176.
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    75. Mettenburg JM, Gonias SL. Beta-amyloid peptide binds equivalently to binary and ternary alpha2-macroglobulin-protease complexes. Protein J. 2005 Feb; 24(2):89-93. PMID: 16003950.
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    76. Wu L, Arandjelovic S, Gonias SL. Effects of low density lipoprotein receptor-related protein-1 on the expression of platelet-derived growth factor beta-receptor in vitro. J Cell Biochem. 2004 Dec 15; 93(6):1169-77. PMID: 15486970.
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    77. Gonias SL, Wu L, Salicioni AM. Low density lipoprotein receptor-related protein: regulation of the plasma membrane proteome. Thromb Haemost. 2004 Jun; 91(6):1056-64. PMID: 15175790.
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    78. Salicioni AM, Gaultier A, Brownlee C, Cheezum MK, Gonias SL. Low density lipoprotein receptor-related protein-1 promotes beta1 integrin maturation and transport to the cell surface. J Biol Chem. 2004 Mar 12; 279(11):10005-12. PMID: 14699139.
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    79. Hope C, Mettenburg J, Gonias SL, DeKosky ST, Kamboh MI, Chu CT. Functional analysis of plasma alpha(2)-macroglobulin from Alzheimer's disease patients with the A2M intronic deletion. Neurobiol Dis. 2003 Dec; 14(3):504-12. PMID: 14678766.
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    80. Jo M, Thomas KS, Wu L, Gonias SL. Soluble urokinase-type plasminogen activator receptor inhibits cancer cell growth and invasion by direct urokinase-independent effects on cell signaling. J Biol Chem. 2003 Nov 21; 278(47):46692-8. PMID: 12963722.
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    81. Schrecengost JE, LeGallo RD, Boyd JC, Moons KG, Gonias SL, Rose CE, Bruns DE. Comparison of diagnostic accuracies in outpatients and hospitalized patients of D-dimer testing for the evaluation of suspected pulmonary embolism. Clin Chem. 2003 Sep; 49(9):1483-90. PMID: 12928229.
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    82. Mathew S, Arandjelovic S, Beyer WF, Gonias SL, Pizzo SV. Characterization of the interaction between alpha2-macroglobulin and fibroblast growth factor-2: the role of hydrophobic interactions. Biochem J. 2003 Aug 15; 374(Pt 1):123-9. PMID: 12755687; PMCID: PMC1223577.
    83. Arandjelovic S, Freed TA, Gonias SL. Growth factor-binding sequence in human alpha2-macroglobulin targets the receptor-binding site in transforming growth factor-beta. Biochemistry. 2003 May 27; 42(20):6121-7. PMID: 12755614.
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    84. Ma Z, Thomas KS, Webb DJ, Moravec R, Salicioni AM, Mars WM, Gonias SL. Regulation of Rac1 activation by the low density lipoprotein receptor-related protein. J Cell Biol. 2002 Dec 23; 159(6):1061-70. PMID: 12499359; PMCID: PMC2173989.
    85. Jo M, Thomas KS, O'Donnell DM, Gonias SL. Epidermal growth factor receptor-dependent and -independent cell-signaling pathways originating from the urokinase receptor. J Biol Chem. 2003 Jan 17; 278(3):1642-6. PMID: 12426305.
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    86. Strickland DK, Gonias SL, Argraves WS. Diverse roles for the LDL receptor family. Trends Endocrinol Metab. 2002 Mar; 13(2):66-74. PMID: 11854021.
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    87. Salicioni AM, Mizelle KS, Loukinova E, Mikhailenko I, Strickland DK, Gonias SL. The low density lipoprotein receptor-related protein mediates fibronectin catabolism and inhibits fibronectin accumulation on cell surfaces. J Biol Chem. 2002 May 03; 277(18):16160-6. PMID: 11867643.
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    88. Mettenburg JM, Webb DJ, Gonias SL. Distinct binding sites in the structure of alpha 2-macroglobulin mediate the interaction with beta-amyloid peptide and growth factors. J Biol Chem. 2002 Apr 12; 277(15):13338-45. PMID: 11823454.
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    89. Jo M, Thomas KS, Somlyo AV, Somlyo AP, Gonias SL. Cooperativity between the Ras-ERK and Rho-Rho kinase pathways in urokinase-type plasminogen activator-stimulated cell migration. J Biol Chem. 2002 Apr 05; 277(14):12479-85. PMID: 11805108.
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    90. Gonias SL, Hembrough TA, Sankovic M. Cytokeratin 8 functions as a major plasminogen receptor in select epithelial and carcinoma cells. Front Biosci. 2001 Nov 01; 6:D1403-11. PMID: 11689350.
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    91. Ma Z, Webb DJ, Jo M, Gonias SL. Endogenously produced urokinase-type plasminogen activator is a major determinant of the basal level of activated ERK/MAP kinase and prevents apoptosis in MDA-MB-231 breast cancer cells. J Cell Sci. 2001 Sep; 114(Pt 18):3387-96. PMID: 11591826.
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    92. Webb DJ, Thomas KS, Gonias SL. Plasminogen activator inhibitor 1 functions as a urokinase response modifier at the level of cell signaling and thereby promotes MCF-7 cell growth. J Cell Biol. 2001 Feb 19; 152(4):741-52. PMID: 11266465; PMCID: PMC2195772.
    93. Webb DJ, Roadcap DW, Dhakephalkar A, Gonias SL. A 16-amino acid peptide from human alpha2-macroglobulin binds transforming growth factor-beta and platelet-derived growth factor-BB. Protein Sci. 2000 Oct; 9(10):1986-92. PMID: 11106172; PMCID: PMC2144455.
    94. Nguyen DH, Webb DJ, Catling AD, Song Q, Dhakephalkar A, Weber MJ, Ravichandran KS, Gonias SL. Urokinase-type plasminogen activator stimulates the Ras/Extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of GRB2/Sps-Shc complex is associated with the transient phosphorylation of ERK in urokinase-treated cells. J Biol Chem. 2000 Jun 23; 275(25):19382-8. PMID: 10777511.
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    95. Gonias SL, Carmichael A, Mettenburg JM, Roadcap DW, Irvin WP, Webb DJ. Identical or overlapping sequences in the primary structure of human alpha(2)-macroglobulin are responsible for the binding of nerve growth factor-beta, platelet-derived growth factor-BB, and transforming growth factor-beta. J Biol Chem. 2000 Feb 25; 275(8):5826-31. PMID: 10681572.
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    96. Garber TR, Gonias SL, Webb DJ. Interleukin-4 and IL-10 bind covalently to activated human alpha2-macroglobulin by a mechanism that requires Cys949. J Interferon Cytokine Res. 2000 Feb; 20(2):125-31. PMID: 10714547.
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    97. Webb DJ, Nguyen DH, Gonias SL. Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration and matrigel invasion. J Cell Sci. 2000 Jan; 113 ( Pt 1):123-34. PMID: 10591631.
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    98. Nguyen DH, Catling AD, Webb DJ, Sankovic M, Walker LA, Somlyo AV, Weber MJ, Gonias SL. Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner. J Cell Biol. 1999 Jul 12; 146(1):149-64. PMID: 10402467.
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    99. Hussaini IM, Brown MD, Weaver AM, Carpenter J, Karns LR, Vandenberg SR, Gonias SL. Stable antisense RNA expression neutralizes the activity of low-density lipoprotein receptor-related protein and promotes urokinase accumulation in the medium of an astrocytic tumor cell line. Antisense Nucleic Acid Drug Dev. 1999 Apr; 9(2):183-90. PMID: 10355824.
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    100. Webb DJ, Nguyen DH, Sankovic M, Gonias SL. The very low density lipoprotein receptor regulates urokinase receptor catabolism and breast cancer cell motility in vitro. J Biol Chem. 1999 Mar 12; 274(11):7412-20. PMID: 10066806.
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    101. Hussaini IM, Brown MD, Karns LR, Carpenter J, Redpath GT, Gonias SL, Vandenberg SR. Epidermal growth factor differentially regulates low density lipoprotein receptor-related protein gene expression in neoplastic and fetal human astrocytes. Glia. 1999 Jan; 25(1):71-84. PMID: 9888299.
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    102. Kralovich KR, Li L, Hembrough TA, Webb DJ, Karns LR, Gonias SL. Characterization of the binding sites for plasminogen and tissue-type plasminogen activator in cytokeratin 8 and cytokeratin 18. J Protein Chem. 1998 Nov; 17(8):845-54. PMID: 9988531.
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    103. Webb DJ, Gonias SL. A modified human alpha 2-macroglobulin derivative that binds tumor necrosis factor-alpha and interleukin-1 beta with high affinity in vitro and reverses lipopolysaccharide toxicity in vivo in mice. Lab Invest. 1998 Aug; 78(8):939-48. PMID: 9714181.
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    104. Webb DJ, Wen J, Karns LR, Kurilla MG, Gonias SL. Localization of the binding site for transforming growth factor-beta in human alpha2-macroglobulin to a 20-kDa peptide that also contains the bait region. J Biol Chem. 1998 May 22; 273(21):13339-46. PMID: 9582381.
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    105. Nguyen DH, Hussaini IM, Gonias SL. Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility. J Biol Chem. 1998 Apr 03; 273(14):8502-7. PMID: 9525964.
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    106. Harthun NL, Weaver AM, Brinckerhoff LH, Deacon DH, Gonias SL, Slingluff CL. Activated alpha 2-macroglobulin reverses the immunosuppressive activity in human breast cancer cell-conditioned medium by selectively neutralizing transforming growth factor-beta in the presence of interleukin-2. J Immunother. 1998 Mar; 21(2):85-94. PMID: 9551359.
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    107. Lysiak JJ, Hussaini IM, Gonias SL. alpha 2-Macroglobulin synthesis by the human monocytic cell line THP-1 is differentiation state-dependent. J Cell Biochem. 1997 Dec 15; 67(4):492-7. PMID: 9383708.
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    108. Weaver AM, Lysiak JJ, Gonias SL. LDL receptor family-dependent and -independent pathways for the internalization and digestion of lipoprotein lipase-associated beta-VLDL by rat vascular smooth muscle cells. J Lipid Res. 1997 Sep; 38(9):1841-50. PMID: 9323593.
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    109. Webb DJ, Gonias SL. Chemical modification of alpha2-macroglobulin to generate derivatives that bind transforming growth factor-beta with increased affinity. FEBS Lett. 1997 Jun 30; 410(2-3):249-53. PMID: 9237639.
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    110. Weaver AM, Hussaini IM, Mazar A, Henkin J, Gonias SL. Embryonic fibroblasts that are genetically deficient in low density lipoprotein receptor-related protein demonstrate increased activity of the urokinase receptor system and accelerated migration on vitronectin. J Biol Chem. 1997 May 30; 272(22):14372-9. PMID: 9162074.
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    111. Brown MD, Banker GA, Hussaini IM, Gonias SL, VandenBerg SR. Low density lipoprotein receptor-related protein is expressed early and becomes restricted to a somatodendritic domain during neuronal differentiation in culture. Brain Res. 1997 Feb 07; 747(2):313-7. PMID: 9046007.
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    112. Webb DJ, Weaver AM, Atkins-Brady TL, Gonias SL. Proteinases are isoform-specific regulators of the binding of transforming growth factor beta to alpha 2-macroglobulin. Biochem J. 1996 Dec 01; 320 ( Pt 2):551-5. PMID: 8973565; PMCID: PMC1217964.
    113. Hembrough TA, Li L, Gonias SL. Cell-surface cytokeratin 8 is the major plasminogen receptor on breast cancer cells and is required for the accelerated activation of cell-associated plasminogen by tissue-type plasminogen activator. J Biol Chem. 1996 Oct 11; 271(41):25684-91. PMID: 8810346.
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    114. Webb DJ, Wen J, Lysiak JJ, Umans L, Van Leuven F, Gonias SL. Murine alpha-macroglobulins demonstrate divergent activities as neutralizers of transforming growth factor-beta and as inducers of nitric oxide synthesis. A possible mechanism for the endotoxin insensitivity of the alpha2-macroglobulin gene knock-out mouse. J Biol Chem. 1996 Oct 04; 271(40):24982-8. PMID: 8798779.
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    115. Weaver AM, McCabe M, Kim I, Allietta MM, Gonias SL. Epidermal growth factor and platelet-derived growth factor-BB induce a stable increase in the activity of low density lipoprotein receptor-related protein in vascular smooth muscle cells by altering receptor distribution and recycling. J Biol Chem. 1996 Oct 04; 271(40):24894-900. PMID: 8798766.
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    116. Hembrough TA, Kralovich KR, Li L, Gonias SL. Cytokeratin 8 released by breast carcinoma cells in vitro binds plasminogen and tissue-type plasminogen activator and promotes plasminogen activation. Biochem J. 1996 Aug 01; 317 ( Pt 3):763-9. PMID: 8760360; PMCID: PMC1217550.
    117. Hussaini IM, LaMarre J, Lysiak JJ, Karns LR, VandenBerg SR, Gonias SL. Transcriptional regulation of LDL receptor-related protein by IFN-gamma and the antagonistic activity of TGF-beta(1) in the RAW 264.7 macrophage-like cell line. J Leukoc Biol. 1996 May; 59(5):733-9. PMID: 8656060.
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    118. Weaver AM, Owens GK, Gonias SL. Native and activated forms of alpha 2-macroglobulin increase expression of platelet-derived growth factor alpha-receptor in vascular smooth muscle cells. Evidence for autocrine transforming growth factor-beta activity. J Biol Chem. 1995 Dec 22; 270(51):30741-8. PMID: 8530514.
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    119. Webb DJ, Hussaini IM, Weaver AM, Atkins TL, Chu CT, Pizzo SV, Owens GK, Gonias SL. Activated alpha 2-macroglobulin promotes mitogenesis in rat vascular smooth muscle cells by a mechanism that is independent of growth-factor-carrier activity. Eur J Biochem. 1995 Dec 15; 234(3):714-22. PMID: 8575427.
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    120. Niemuller CA, Randall KJ, Webb DJ, Gonias SL, LaMarre J. Alpha 2-macroglobulin conformation determines binding affinity for activin A and plasma clearance of activin A/alpha 2-macroglobulin complex. Endocrinology. 1995 Dec; 136(12):5343-9. PMID: 7588280.
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    121. Webb DJ, Crookston KP, Figler NL, Lamarre J, Gonias SL. Differences in the binding of transforming growth factor beta 1 to the acute-phase reactant and constitutively synthesized alpha-macroglobulins of rat. Biochem J. 1995 Dec 01; 312 ( Pt 2):579-86. PMID: 8526873; PMCID: PMC1136301.
    122. Lysiak JJ, Hussaini IM, Webb DJ, Glass WF, Allietta M, Gonias SL. Alpha 2-macroglobulin functions as a cytokine carrier to induce nitric oxide synthesis and cause nitric oxide-dependent cytotoxicity in the RAW 264.7 macrophage cell line. J Biol Chem. 1995 Sep 15; 270(37):21919-27. PMID: 7545171.
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    123. Hembrough TA, Vasudevan J, Allietta MM, Glass WF, Gonias SL. A cytokeratin 8-like protein with plasminogen-binding activity is present on the external surfaces of hepatocytes, HepG2 cells and breast carcinoma cell lines. J Cell Sci. 1995 Mar; 108 ( Pt 3):1071-82. PMID: 7542667.
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    124. Wolf BB, Gibson CA, Kapur V, Hussaini IM, Musser JM, Gonias SL. Proteolytically active streptococcal pyrogenic exotoxin B cleaves monocytic cell urokinase receptor and releases an active fragment of the receptor from the cell surface. J Biol Chem. 1994 Dec 02; 269(48):30682-7. PMID: 7982988.
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    125. Webb DJ, Atkins TL, Crookston KP, Burmester JK, Qian SW, Gonias SL. Transforming growth factor beta isoform 2-specific high affinity binding to native alpha 2-macroglobulin. Chimeras identify a sequence that determines affinity for native but not activated alpha 2-macroglobulin. J Biol Chem. 1994 Dec 02; 269(48):30402-6. PMID: 7527030.
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    126. Humphries JE, Gonias SL, Pizzo SV, Williams ME. Life-long bleeding diathesis: effect of orthotopic liver transplantation. Am J Clin Pathol. 1994 Dec; 102(6):816-20. PMID: 7801898.
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    127. Wolf BB, Gonias SL. Neurotrophin binding to human alpha 2-macroglobulin under apparent equilibrium conditions. Biochemistry. 1994 Sep 20; 33(37):11270-7. PMID: 7537086.
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    128. Gonias SL, LaMarre J, Crookston KP, Webb DJ, Wolf BB, Lopes MB, Moses HL, Hayes MA. Alpha 2-macroglobulin and the alpha 2-macroglobulin receptor/LRP. A growth regulatory axis. Ann N Y Acad Sci. 1994 Sep 10; 737:273-90. PMID: 7524402.
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    129. Lamarre J, Vasudevan J, Gonias SL. Plasmin cleaves betaglycan and releases a 60 kDa transforming growth factor-beta complex from the cell surface. Biochem J. 1994 Aug 15; 302 ( Pt 1):199-205. PMID: 8068006; PMCID: PMC1137210.
    130. Crookston KP, Gonias SL. The role of cysteine-949 in the binding of transforming growth factor-beta 1 and transforming growth factor-beta 2 to alpha 2-macroglobulin. Biochem Biophys Res Commun. 1994 May 16; 200(3):1578-85. PMID: 7514405.
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    131. Wang MH, Gonias SL, Skeel A, Wolf BB, Yoshimura T, Leonard EJ. Proteolytic activation of single-chain precursor macrophage-stimulating protein by nerve growth factor-gamma and epidermal growth factor-binding protein, members of the kallikrein family. J Biol Chem. 1994 May 13; 269(19):13806-10. PMID: 8188657.
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    132. Sutton R, Keohane ME, VanderBerg SR, Gonias SL. Plasminogen activator inhibitor-1 in the cerebrospinal fluid as an index of neurological disease. Blood Coagul Fibrinolysis. 1994 Apr; 5(2):167-71. PMID: 8054448.
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    133. Reddy VY, Desorchers PE, Pizzo SV, Gonias SL, Sahakian JA, Levine RL, Weiss SJ. Oxidative dissociation of human alpha 2-macroglobulin tetramers into dysfunctional dimers. J Biol Chem. 1994 Feb 11; 269(6):4683-91. PMID: 7508448.
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    134. Lopes MB, Bogaev CA, Gonias SL, VandenBerg SR. Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein is increased in reactive and neoplastic glial cells. FEBS Lett. 1994 Feb 07; 338(3):301-5. PMID: 8307199.
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    135. Crookston KP, Webb DJ, Wolf BB, Gonias SL. Classification of alpha 2-macroglobulin-cytokine interactions based on affinity of noncovalent association in solution under apparent equilibrium conditions. J Biol Chem. 1994 Jan 14; 269(2):1533-40. PMID: 7507109.
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    136. Turner JS, Redpath GT, Humphries JE, Gonias SL, Vandenberg SR. Plasmin modulates the thrombin-evoked calcium response in C6 glioma cells. Biochem J. 1994 Jan 01; 297 ( Pt 1):175-9. PMID: 8280096; PMCID: PMC1137807.
    137. Gasperetti CM, Gonias SL, Gimple LW, Powers ER. Platelet activation during coronary angioplasty in humans. Circulation. 1993 Dec; 88(6):2728-34. PMID: 8252685.
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    138. Stouffer GA, LaMarre J, Gonias SL, Owens GK. Activated alpha 2-macroglobulin and transforming growth factor-beta 1 induce a synergistic smooth muscle cell proliferative response. J Biol Chem. 1993 Aug 25; 268(24):18340-4. PMID: 7688745.
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    139. Wolf BB, Vasudevan J, Henkin J, Gonias SL. Nerve growth factor-gamma activates soluble and receptor-bound single chain urokinase-type plasminogen activator. J Biol Chem. 1993 Aug 05; 268(22):16327-31. PMID: 8393859.
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    140. Crookston KP, Webb DJ, Lamarre J, Gonias SL. Binding of platelet-derived growth factor-BB and transforming growth factor-beta 1 to alpha 2-macroglobulin in vitro and in vivo: comparison of receptor-recognized and non-recognized alpha 2-macroglobulin conformations. Biochem J. 1993 Jul 15; 293 ( Pt 2):443-50. PMID: 7688216; PMCID: PMC1134380.
    141. Vasudevan J, Humphries JE, Gonias SL. Binding of anisoylated Lys-plasminogen streptokinase activator complex to cells in culture. Thromb Haemost. 1993 Apr 01; 69(4):370-4. PMID: 8388580.
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    142. Gonias SL, Marshall LB, Figler NL, Hussaini IM, Moncino MD, Pizzo SV. Electron microscopy studies of alpha 2-macroglobulin subunit association after limited reduction with dithiothreitol. Arch Biochem Biophys. 1993 Apr; 302(1):42-8. PMID: 7682394.
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    143. LaMarre J, Wolf BB, Kittler EL, Quesenberry PJ, Gonias SL. Regulation of macrophage alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein by lipopolysaccharide and interferon-gamma. J Clin Invest. 1993 Mar; 91(3):1219-24. PMID: 7680664; PMCID: PMC288080.
    144. Wolf BB, Vasudevan J, Gonias SL. Reaction of nerve growth factor gamma and 7S nerve growth factor complex with human and murine alpha 2-macroglobulin. Biochemistry. 1993 Feb 23; 32(7):1875-82. PMID: 7679924.
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    145. Anonick PK, Yoo JK, Webb DJ, Gonias SL. Characterization of the antiplasmin activity of human thrombospondin-1 in solution. Biochem J. 1993 Feb 01; 289 ( Pt 3):903-9. PMID: 7679575; PMCID: PMC1132261.
    146. Humphries JE, Vasudevan J, Gonias SL. Fibrinogenolytic and fibrinolytic activity of cell-associated plasmin. Arterioscler Thromb. 1993 Jan; 13(1):48-55. PMID: 7678497.
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    147. Pipan CM, Glasheen WP, Matthew TL, Gonias SL, Hwang LJ, Jane JA, Spotnitz WD. Effects of antifibrinolytic agents on the life span of fibrin sealant. J Surg Res. 1992 Oct; 53(4):402-7. PMID: 1383616.
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    148. Wolf BB, Lopes MB, VandenBerg SR, Gonias SL. Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain. Am J Pathol. 1992 Jul; 141(1):37-42. PMID: 1632469; PMCID: PMC1886577.
    149. Anonick PK, Vasudevan J, Gonias SL. Antifibrinolytic activities of alpha-N-acetyl-L-lysine methyl ester, epsilon-aminocaproic acid, and tranexamic acid. Importance of kringle interactions and active site inhibition. Arterioscler Thromb. 1992 Jun; 12(6):708-16. PMID: 1375508.
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    150. Marshall LB, Figler NL, Gonias SL. Identification of alpha 2-macroglobulin conformational intermediates by electron microscopy and image analysis. Comparison of alpha 2-macroglobulin-thrombin and alpha 2-macroglobulin reacted with cis-dichlorodiammineplatinum(II) and trypsin. J Biol Chem. 1992 Mar 25; 267(9):6347-52. PMID: 1372906.
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    151. Gonias SL. Alpha 2-macroglobulin: a protein at the interface of fibrinolysis and cellular growth regulation. Exp Hematol. 1992 Mar; 20(3):302-11. PMID: 1373682.
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    152. Webb DJ, Crookston KP, Hall SW, Gonias SL. Binding of transforming growth factor-beta 1 to immobilized human alpha 2-macroglobulin. Arch Biochem Biophys. 1992 Feb 01; 292(2):487-92. PMID: 1370602.
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    153. Hall SW, LaMarre J, Marshall LB, Hayes MA, Gonias SL. Binding of transforming growth factor-beta 1 to methylamine-modified alpha 2-macroglobulin and to binary and ternary alpha 2-macroglobulin-proteinase complexes. Biochem J. 1992 Jan 15; 281 ( Pt 2):569-75. PMID: 1371050; PMCID: PMC1130723.
    154. Webb DJ, LaMarre J, Gonias SL. Effect of human alpha-thrombin on the transforming growth factor-beta 1-binding activity of human alpha 2-macroglobulin. Semin Thromb Hemost. 1992; 18(3):305-10. PMID: 1280859.
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    155. Humphries JE, Schlein AE, Sarembock IJ, Gonias SL. Myocardial infarction in a patient with factor XI deficiency and a lupus anticoagulant. Eur Heart J. 1991 Sep; 12(9):1045-7. PMID: 1936005.
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    156. Hall SW, Humphries JE, Gonias SL. Inhibition of cell surface receptor-bound plasmin by alpha 2-antiplasmin and alpha 2-macroglobulin. J Biol Chem. 1991 Jul 05; 266(19):12329-36. PMID: 1712017.
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    157. LaMarre J, Wollenberg GK, Gonias SL, Hayes MA. Cytokine binding and clearance properties of proteinase-activated alpha 2-macroglobulins. Lab Invest. 1991 Jul; 65(1):3-14. PMID: 1712874.
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    158. Figler NL, Strickland DK, Allietta M, Gonias SL. Immunoelectron microscopy studies with a monoclonal antibody directed against a receptor recognition site epitope in human alpha 2-macroglobulin. J Struct Biol. 1991 Jun; 106(3):237-42. PMID: 1725127.
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    159. Anonick PK, Gonias SL. Soluble fibrin preparations inhibit the reaction of plasmin with alpha 2-macroglobulin. Comparison with alpha 2-antiplasmin and leupeptin. Biochem J. 1991 Apr 01; 275 ( Pt 1):53-9. PMID: 1708234; PMCID: PMC1150012.
    160. Wollenberg GK, LaMarre J, Rosendal S, Gonias SL, Hayes MA. Binding of tumor necrosis factor alpha to activated forms of human plasma alpha 2 macroglobulin. Am J Pathol. 1991 Feb; 138(2):265-72. PMID: 1704186; PMCID: PMC1886187.
    161. LaMarre J, Wollenberg GK, Gonias SL, Hayes MA. Reaction of alpha 2-macroglobulin with plasmin increases binding of transforming growth factors-beta 1 and beta 2. Biochim Biophys Acta. 1991 Jan 31; 1091(2):197-204. PMID: 1704799.
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    162. LaMarre J, Hayes MA, Wollenberg GK, Hussaini I, Hall SW, Gonias SL. An alpha 2-macroglobulin receptor-dependent mechanism for the plasma clearance of transforming growth factor-beta 1 in mice. J Clin Invest. 1991 Jan; 87(1):39-44. PMID: 1702100; PMCID: PMC294986.
    163. Hussaini IM, Srikumar K, Quesenberry PJ, Gonias SL. Colony-stimulating factor-1 modulates alpha 2-macroglobulin receptor expression in murine bone marrow macrophages. J Biol Chem. 1990 Nov 15; 265(32):19441-6. PMID: 1700978.
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    164. Enghild JJ, Thøgersen IB, Salvesen G, Fey GH, Figler NL, Gonias SL, Pizzo SV. Alpha-macroglobulin from Limulus polyphemus exhibits proteinase inhibitory activity and participates in a hemolytic system. Biochemistry. 1990 Oct 30; 29(43):10070-80. PMID: 1703001.
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    165. Hussaini IM, Figler NL, Gonias SL. The structure of alpha 2-macroglobulin-methylamine after papain digestion as determined by electron microscopy. Biochem J. 1990 Sep 01; 270(2):291-5. PMID: 1698054; PMCID: PMC1131718.
    166. Keohane ME, Hall SW, VandenBerg SR, Gonias SL. Secretion of alpha 2-macroglobulin, alpha 2-antiplasmin, and plasminogen activator inhibitor-1 by glioblastoma multiforme in primary organ culture. J Neurosurg. 1990 Aug; 73(2):234-41. PMID: 1694891.
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    167. Anonick PK, Wolf B, Gonias SL. Regulation of plasmin, miniplasmin, and streptokinase-plasmin complex by alpha 2-antiplasmin, alpha 2-macroglobulin, and antithrombin III in the presence of heparin. Thromb Res. 1990 Aug 01; 59(3):449-62. PMID: 1700488.
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    168. Hall SW, VandenBerg SR, Gonias SL. Plasminogen carbohydrate side chains in receptor binding and enzyme activation: a study of C6 glioma cells and primary cultures of rat hepatocytes. J Cell Biochem. 1990 Jul; 43(3):213-27. PMID: 1696276.
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    169. Schwartzman JD, Gonias SL, Pfefferkorn ER. Murine gamma interferon fails to inhibit Toxoplasma gondii growth in murine fibroblasts. Infect Immun. 1990 Mar; 58(3):833-4. PMID: 2106497; PMCID: PMC258541.
    170. Baramova EN, Shannon JD, Bjarnason JB, Gonias SL, Fox JW. Interaction of hemorrhagic metalloproteinases with human alpha 2-macroglobulin. Biochemistry. 1990 Jan 30; 29(4):1069-74. PMID: 1692735.
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    171. Anonick PK, Vetter WH, Gonias SL. Kinetics of the reaction of streptokinase-plasmin complex with purified human and mouse alpha 2-macroglobulin. Implications for mechanism. Biochem J. 1989 Dec 15; 264(3):745-52. PMID: 2482733; PMCID: PMC1133648.
    172. VandenBerg SR, Britt SG, Redpath GT, Gonias SL. 5-Hydroxytryptamine2 (5-HT2) structure-function relationships of the nitro and amino phenylpiperazines on intact human platelets. Biochem Pharmacol. 1989 Dec 01; 38(23):4237-44. PMID: 2597195.
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    173. Hall SW, Braud LL, Gonias SL. Binding of bovine, ovine, porcine, canine, and rat plasminogen to rat hepatocytes and rat C6 glioma cells in vitro. Biochem Biophys Res Commun. 1989 Nov 15; 164(3):1288-94. PMID: 2556124.
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    174. Gonias SL, Young WW, Fox JW. Cleavage of recombinant murine interferon-gamma by plasmin and miniplasmin. J Interferon Res. 1989 Oct; 9(5):517-29. PMID: 2529320.
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    175. Hall SW, VandenBerg SR, Gonias SL. Expression of plasminogen receptors on C6 glioma cells. Brain Res. 1989 Aug 28; 495(2):373-6. PMID: 2548675.
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    176. Gonias SL, Braud LL, Geary WA, VandenBerg SR. Plasminogen binding to rat hepatocytes in primary culture and to thin slices of rat liver. Blood. 1989 Aug 01; 74(2):729-36. PMID: 2546631.
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    177. Gonias SL, Figler NL. Electron microscopy studies of alpha 2-macroglobulin conformational intermediates obtained by derivatization with cis-dichlorodiammineplatinum (II). J Biol Chem. 1989 Jun 05; 264(16):9565-70. PMID: 2470758.
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    178. Geary WA, Gonias SL. Inactivation of alpha 2-antiplasmin by limited reaction with cis-dichlorodiammineplatinum (II) Biochim Biophys Acta. 1989 Jan 19; 994(1):1-6. PMID: 2521201.
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    179. VandenBerg SR, Gonias SL. Covalent complexes of albumin with serotonin, ketanserin and lysergic acid antagonize the activity of serotonin in human platelets. Life Sci. 1989; 44(23):1777-85. PMID: 2733551.
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    180. Britt SG, Gonias SL, Sanders JM, Vandenberg SR. Agonist and antagonist activities of arylpiperazines at human platelet serotonin2 receptors. J Pharmacol Exp Ther. 1988 Dec; 247(3):965-70. PMID: 3204525.
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    181. Gonias SL, Figler NL, Braud LL. Regulation of streptokinase-human plasmin complex by the plasma proteinase inhibitors alpha 2-antiplasmin and alpha 2-macroglobulin is species specific and temperature dependent. Blood. 1988 Nov; 72(5):1658-64. PMID: 2460159.
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    182. Gonias SL, Figler NL. Alpha 2-macroglobulin is the primary inhibitor of miniplasmin in vitro and in vivo in the mouse. Comparison with alpha 2-antiplasmin in simultaneous reaction experiments. Biochem J. 1988 Oct 15; 255(2):725-30. PMID: 2462416; PMCID: PMC1135286.
    183. Gonias SL, Allietta MM, Pizzo SV, Castellino FJ, Tillack TW. Electron microscopic identification of exposed plasmin epitopes in alpha 2-macroglobulin-plasmin complex using monoclonal antibody-colloidal gold adducts. J Biol Chem. 1988 Aug 05; 263(22):10903-6. PMID: 2455719.
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    184. Pizzo SV, Swaim MW, Roche PA, Gonias SL. Selectivity and stereospecificity of the reactions of dichlorodiammineplatinum(II) with three purified plasma proteins. J Inorg Biochem. 1988 May; 33(1):67-76. PMID: 2454291.
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    185. Gonias SL, Pizzo SV, Hoffman M. Clearance and distribution of recombinant murine gamma-interferon in mice. Cancer Res. 1988 Apr 15; 48(8):2021-4. PMID: 3127042.
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    186. Gonias SL, Swaim MW, Massey MF, Pizzo SV. cis-dichlorodiammineplatinum (II) as a selective modifier of the oxidation-sensitive reactive-center methionine in alpha 1-antitrypsin. J Biol Chem. 1988 Jan 05; 263(1):393-7. PMID: 3257210.
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    187. Prpic V, Weiel JE, Somers SD, DiGuiseppi J, Gonias SL, Pizzo SV, Hamilton TA, Herman B, Adams DO. Effects of bacterial lipopolysaccharide on the hydrolysis of phosphatidylinositol-4,5-bisphosphate in murine peritoneal macrophages. J Immunol. 1987 Jul 15; 139(2):526-33. PMID: 3036944.
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    188. Huang AT, Silverstein L, Gonias SL, Rundles RW, Raab-Traub N. Transformation of hairy cell leukemia to EBV genome-containing aggressive B cell lymphoma. Leukemia. 1987 Apr; 1(4):369-72. PMID: 2823016.
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    189. Rajagopalan S, Gonias SL, Pizzo SV. The temperature-dependent reaction between alpha 2-macroglobulin and streptokinase-plasmin(ogen) complex. J Biol Chem. 1987 Mar 15; 262(8):3660-4. PMID: 2434504.
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    190. Pizzo SV, Turner AD, Porter NA, Gonias SL. Evaluation of p-amidinophenyl esters as potential antithrombotic agents. Thromb Haemost. 1986 Dec 15; 56(3):387-90. PMID: 2436336.
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    191. Pizzo SV, Rajagopalan S, Roche PA, Fuchs HE, Feldman SR, Gonias SL. Specificity of alpha 2-macroglobulin covalent cross-linking for the active domain of proteinases. Biol Chem Hoppe Seyler. 1986 Nov; 367(11):1177-82. PMID: 2434119.
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    192. Pizzo SV, Roche PA, Feldman SR, Gonias SL. Further characterization of the platinum-reactive component of the alpha 2-macroglobulin-receptor recognition site. Biochem J. 1986 Aug 15; 238(1):217-25. PMID: 3026342; PMCID: PMC1147118.
    193. Pizzo SV, Murray JC, Gonias SL. Atrophie blanche. A disorder associated with defective release of tissue plasminogen activator. Arch Pathol Lab Med. 1986 Jun; 110(6):517-9. PMID: 3085632.
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    194. Gonias SL, Roche PA, Pizzo SV. Purification and characterization of human alpha 2-macroglobulin conformational variants by non-ideal high performance size-exclusion chromatography. Biochem J. 1986 Apr 15; 235(2):559-67. PMID: 2427074; PMCID: PMC1146721.
    195. Pizzo SV, Turner AD, Gonias SL, Monroe DM, Roberts HR, Porter NA. Nontoxic irreversible inhibitors of factors IXa, Xa, and thrombin: potential therapeutic agents for the in vivo regulation of thrombin generation and activity. Ann N Y Acad Sci. 1986; 485:199-203. PMID: 3494415.
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    196. Gonias SL, Pizzo SV. The biochemistry of haemostasis. Clin Lab Haematol. 1986; 8(4):281-306. PMID: 3024901.
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    197. Feldman SR, Gonias SL, Pizzo SV. Model of alpha 2-macroglobulin structure and function. Proc Natl Acad Sci U S A. 1985 Sep; 82(17):5700-4. PMID: 2412223; PMCID: PMC390619.
    198. Gonias SL, Pasqua JJ, Greenberg C, Pizzo SV. Precipitation of fibrinogen, fibrinogen degradation products and fibrin monomer by histone H3. Thromb Res. 1985 Jul 01; 39(1):97-116. PMID: 4035652.
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    199. Balber AE, Gonias SL, Pizzo SV. Trypanosoma brucei gambiense: growth in vitro of bloodstream forms inhibited by dichlorodiammineplatinum (II) compounds and hypolipidemic drugs. Exp Parasitol. 1985 Feb; 59(1):74-80. PMID: 4038488.
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    200. Rajagopalan S, Gonias SL, Pizzo SV. A nonantigenic covalent streptokinase-polyethylene glycol complex with plasminogen activator function. J Clin Invest. 1985 Feb; 75(2):413-9. PMID: 3156148; PMCID: PMC423508.
    201. Gonias SL, Oakley AC, Walther PJ, Pizzo SV. Effects of diethyldithiocarbamate and nine other nucleophiles on the intersubunit protein cross-linking and inactivation of purified human alpha 2-macroglobulin by cis-diamminedichloroplatinum(II). Cancer Res. 1984 Dec; 44(12 Pt 1):5764-70. PMID: 6209003.
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    202. Gonias SL, Feldman SR, Pratt CW, Pizzo SV. Conformation-specific precipitation of human alpha 2-macroglobulin by divalent zinc or calf thymus histone H3. Arch Biochem Biophys. 1984 Sep; 233(2):462-8. PMID: 6207774.
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    203. Feldman SR, Gonias SL, Ney KA, Pratt CW, Pizzo SV. Identification of "embryonin" as bovine alpha 2-macroglobulin. J Biol Chem. 1984 Apr 10; 259(7):4458-62. PMID: 6200483.
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    204. Gonias SL, Pizzo SV. Conformation and protease binding activity of binary and ternary human alpha 2-macroglobulin-protease complexes. J Biol Chem. 1983 Dec 10; 258(23):14682-5. PMID: 6196365.
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    205. Gonias SL, Pizzo SV. Reaction of human alpha 2-macroglobulin half-molecules with plasmin as a probe of protease binding site structure. Biochemistry. 1983 Oct 11; 22(21):4933-40. PMID: 6196052.
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    206. Feldman SR, Ney KA, Gonias SL, Pizzo SV. In vitro binding and in vivo clearance of human alpha 2-macroglobulin after reaction with endoproteases from four different classes. Biochem Biophys Res Commun. 1983 Jul 29; 114(2):757-62. PMID: 6192823.
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    207. Gonias SL, Pizzo SV. Complexes of serum albumin and cis-dichlorodiammineplatinum (II). The role of cysteine 34 as a nucleophilic entering group and evidence for reaction between bound platinum and a second macromolecule. J Biol Chem. 1983 May 10; 258(9):5764-9. PMID: 6189837.
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    208. Beauchamp CO, Gonias SL, Menapace DP, Pizzo SV. A new procedure for the synthesis of polyethylene glycol-protein adducts; effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin, and alpha 2-macroglobulin. Anal Biochem. 1983 May; 131(1):25-33. PMID: 6193731.
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    209. Gonias SL, Pizzo SV. Characterization of functional human alpha 2-macroglobulin half-molecules isolated by limited reduction with dithiothreitol. Biochemistry. 1983 Feb 01; 22(3):536-46. PMID: 6188480.
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    210. Gonias SL, Pizzo SV. Chemical and structural modifications of alpha 2-macroglobulin: effects on receptor binding and endocytosis studied in an in vivo model. Ann N Y Acad Sci. 1983; 421:457-71. PMID: 6202219.
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    211. Gonias SL, Balber AE, Hubbard WJ, Pizzo SV. Ligand binding, conformational change and plasma elimination of human, mouse and rat alpha-macroglobulin proteinase inhibitors. Biochem J. 1983 Jan 01; 209(1):99-105. PMID: 6189480; PMCID: PMC1154060.
    212. Gonias SL, Fuchs HE, Pizzo SV. A unique pathway for the plasma elimination of alpha 2-antiplasmin-protease complexes in mice. Thromb Haemost. 1982 Oct 29; 48(2):208-10. PMID: 6758181.
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    213. Gonias SL, Reynolds JA, Pizzo SV. Physical properties of human alpha 2-macroglobulin following reaction with methylamine and trypsin. Biochim Biophys Acta. 1982 Aug 10; 705(3):306-14. PMID: 6181812.
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    214. Gonias SL, Einarsson M, Pizzo SV. Catabolic pathways for streptokinase, plasmin, and streptokinase activator complex in mice. In vivo reaction of plasminogen activator with alpha 2-macroglobulin. J Clin Invest. 1982 Aug; 70(2):412-23. PMID: 6178757; PMCID: PMC371250.
    215. Gonias SL, Pizzo SV. Inactivation of the plasma protease inhibitor alpha 2-macroglobulin by the antitumor drug cis-dichlorodiamineplatinum(II). J Biol Chem. 1981 Dec 10; 256(23):12478-84. PMID: 6170643.
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    216. Gonias SL, Pizzo SV. Altered clearance of human alpha 2-macroglobulin complexes following reaction with cis-dichlorodiamineplatinum(II). Biochim Biophys Acta. 1981 Dec 04; 678(2):268-74. PMID: 6172155.
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    217. Bauer W, Gonias SL, Kam SK, Wu KC, Lippard SJ. Binding of the antitumor drug platinum uracil blue to closed and nicked circular duplex DNAs. Biochemistry. 1978 Mar 21; 17(6):1060-8. PMID: 629945.
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