Steven Gonias

Title(s)Professor, Pathology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
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    A novel role for Reelin therapeutics in inflammatory bowel disease
    NIH R41DK126520Sep 1, 2020 - Aug 31, 2021
    Role: Co-Principal Investigator
    Regulation of Inflammation by the Fibrinolytic System
    NIH R01HL136395Apr 10, 2017 - Mar 31, 2021
    Role: Principal Investigator
    Schwann Cell NMDA Receptor in PNS Injury
    NIH R01NS097590Feb 1, 2017 - Jan 31, 2021
    Role: Principal Investigator
    Targeting the Urokinase Receptor in Glioblastoma Multiforme
    NIH R01CA169096Mar 1, 2013 - Feb 28, 2019
    Role: Principal Investigator
    Alpha2-macroglobulin in peripheral nerve injury
    NIH R01NS054671Jul 1, 2007 - Jun 30, 2013
    Role: Principal Investigator
    Gordon Research Conference 2006 Plasminogen Activation
    NIH R13HL083676Sep 30, 2005 - Aug 31, 2006
    Role: Principal Investigator
    Urokinase Receptor-initiated Cell-signaling
    NIH R01CA094900Apr 1, 2002 - Aug 31, 2012
    Role: Principal Investigator
    Regulation of Signaling Receptor Activity by LRP-1
    NIH R01HL060551Aug 1, 1999 - Dec 31, 2015
    Role: Principal Investigator
    Regulation of Growth Factor Activity by A2 Macroglobulin
    NIH R01CA053462Aug 1, 1992 - May 31, 2007
    Role: Principal Investigator
    ENVIRONMENTAL MODULATION OF FIBRINOLYSIS INHIBITORS
    NIH R01HL045786Sep 30, 1990 - Jul 31, 1994
    Role: Principal Investigator
    PROTEINASE IN FIBRINOLYSIS AND THROMBOLYTIC THERAPY
    NIH K04HL002272Jul 1, 1989 - Jun 30, 1994
    Role: Principal Investigator
    University of Virginia Cancer Center Support Grant
    NIH P30CA044579Jul 1, 1987 - Jan 31, 2022
    Role: Co-Investigator
    Medical Scientist Training Program
    NIH T32GM007267Jul 1, 1977 - Jun 30, 2025
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. SARS-CoV-2 Serology Status Detected by Commercialized Platforms Distinguishes Previous Infection and Vaccination Adaptive Immune Responses. J Appl Lab Med. 2021 Jun 25. Suhandynata RT, Bevins NJ, Tran JT, Huang D, Hoffman MA, Lund K, Kelner MJ, McLawhon RW, Gonias SL, Nemazee D, Fitzgerald RL. PMID: 34170314.
      View in: PubMed   Mentions:    Fields:    
    2. SARS-CoV-2 Serology Status Detected by Commercialized Platforms Distinguishes Previous Infection and Vaccination Adaptive Immune Responses. medRxiv. 2021 Mar 12. Suhandynata RT, Bevins NJ, Tran JT, Huang D, Hoffman MA, Lund K, Kelner MJ, McLawhon RW, Gonias SL, Nemazee D, Fitzgerald RL. PMID: 33758902.
      View in: PubMed   Mentions:
    3. Enzymatically Inactive Tissue-Type Plasminogen Activator Reverses Disease Progression in the Dextran Sulfate Sodium Mouse Model of Inflammatory Bowel Disease. Am J Pathol. 2021 04; 191(4):590-601. Das L, Banki MA, Azmoon P, Pizzo D, Gonias SL. PMID: 33465348.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    4. Deletion of the Gene Encoding the NMDA Receptor GluN1 Subunit in Schwann Cells Causes Ultrastructural Changes in Remak Bundles and Hypersensitivity in Pain Processing. J Neurosci. 2020 11 18; 40(47):9121-9136. Brifault C, Romero H, Van-Enoo A, Pizzo D, Azmoon P, Kwon H, Nasamran C, Gonias SL, Campana WM. PMID: 33051351.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. A soluble derivative of PrPC activates cell-signaling and regulates cell physiology through LRP1 and the NMDA receptor. J Biol Chem. 2020 10 09; 295(41):14178-14188. Mantuano E, Azmoon P, Banki MA, Lam MS, Sigurdson CJ, Gonias SL. PMID: 32788217.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Plasminogen Receptors in Human Malignancies: Effects on Prognosis and Feasibility as Targets for Drug Development. Curr Drug Targets. 2020; 21(7):647-656. Gonias SL, Zampieri C. PMID: 31755385.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    7. Tissue-type plasminogen activator-primed human iPSC-derived neural progenitor cells promote motor recovery after severe spinal cord injury. Sci Rep. 2019 12 17; 9(1):19291. Shiga Y, Shiga A, Mesci P, Kwon H, Brifault C, Kim JH, Jeziorski JJ, Nasamran C, Ohtori S, Muotri AR, Gonias SL, Campana WM. PMID: 31848365.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines. J Neuroinflammation. 2019 Dec 06; 16(1):257. Pontecorvi P, Banki MA, Zampieri C, Zalfa C, Azmoon P, Kounnas MZ, Marchese C, Gonias SL, Mantuano E. PMID: 31810478.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    9. Tissue-type plasminogen activator selectively inhibits multiple toll-like receptors in CSF-1-differentiated macrophages. PLoS One. 2019; 14(11):e0224738. Das L, Azmoon P, Banki MA, Mantuano E, Gonias SL. PMID: 31697716.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Hepatocyte tPA: where have you been hiding? Blood. 2019 02 14; 133(7):631-632. Gonias SL. PMID: 30765497.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    11. LRP1 deficiency in microglia blocks neuro-inflammation in the spinal dorsal horn and neuropathic pain processing. Glia. 2019 06; 67(6):1210-1224. Brifault C, Kwon H, Campana WM, Gonias SL. PMID: 30746765.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    12. Tissue-type plasminogen activator neutralizes LPS but not protease-activated receptor-mediated inflammatory responses to plasmin. J Leukoc Biol. 2019 04; 105(4):729-740. Zalfa C, Azmoon P, Mantuano E, Gonias SL. PMID: 30690783.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    13. Mechanisms by Which LRP1 (Low-Density Lipoprotein Receptor-Related Protein-1) Maintains Arterial Integrity. Arterioscler Thromb Vasc Biol. 2018 11; 38(11):2548-2549. Gonias SL. PMID: 30354248.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    14. PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology. J Cell Sci. 2018 07 26; 131(14). Gonias SL, Banki MA, Gilder AS, Azmoon P, Campana WM, Mantuano E. PMID: 29930084.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    15. Schwann cells regulate sensory neuron gene expression before and after peripheral nerve injury. Glia. 2018 08; 66(8):1577-1590. Poplawski G, Ishikawa T, Brifault C, Lee-Kubli C, Regestam R, Henry KW, Shiga Y, Kwon H, Ohtori S, Gonias SL, Campana WM. PMID: 29520865.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    16. The Urokinase Receptor Induces a Mesenchymal Gene Expression Signature in Glioblastoma Cells and Promotes Tumor Cell Survival in Neurospheres. Sci Rep. 2018 02 14; 8(1):2982. Gilder AS, Natali L, Van Dyk DM, Zalfa C, Banki MA, Pizzo DP, Wang H, Klemke RL, Mantuano E, Gonias SL. PMID: 29445239.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    17. Expression of LDL receptor-related proteins (LRPs) in common solid malignancies correlates with patient survival. PLoS One. 2017; 12(10):e0186649. Gonias SL, Karimi-Mostowfi N, Murray SS, Mantuano E, Gilder AS. PMID: 29088295.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    18. Shedding of membrane-associated LDL receptor-related protein-1 from microglia amplifies and sustains neuroinflammation. J Biol Chem. 2017 11 10; 292(45):18699-18712. Brifault C, Gilder AS, Laudati E, Banki M, Gonias SL. PMID: 28972143.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    19. Tissue-type plasminogen activator regulates macrophage activation and innate immunity. Blood. 2017 09 14; 130(11):1364-1374. Mantuano E, Azmoon P, Brifault C, Banki MA, Gilder AS, Campana WM, Gonias SL. PMID: 28684538.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    20. Ionotropic glutamate receptors activate cell signaling in response to glutamate in Schwann cells. FASEB J. 2017 04; 31(4):1744-1755. Campana WM, Mantuano E, Azmoon P, Henry K, Banki MA, Kim JH, Pizzo DP, Gonias SL. PMID: 28073836.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    21. Pertussis Toxin Is a Robust and Selective Inhibitor of High Grade Glioma Cell Migration and Invasion. PLoS One. 2016; 11(12):e0168418. Gilder AS, Wang L, Natali L, Karimi-Mostowfi N, Brifault C, Gonias SL. PMID: 27977780.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    22. Evidence that LDL receptor-related protein 1 acts as an early injury detection receptor and activates c-Jun in Schwann cells. Neuroreport. 2016 12 14; 27(18):1305-1311. Flütsch A, Henry K, Mantuano E, Lam MS, Shibayama M, Takahashi K, Gonias SL, Campana WM. PMID: 27824728.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    23. mTORC2 activation is regulated by the urokinase receptor (uPAR) in bladder cancer. Cell Signal. 2017 01; 29:96-106. Hau AM, Leivo MZ, Gilder AS, Hu JJ, Gonias SL, Hansel DE. PMID: 27777073.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    24. The activities of LDL Receptor-related Protein-1 (LRP1) compartmentalize into distinct plasma membrane microdomains. Mol Cell Neurosci. 2016 10; 76:42-51. Laudati E, Gilder AS, Lam MS, Misasi R, Sorice M, Gonias SL, Mantuano E. PMID: 27565578.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    25. LDL receptor-related protein-1 regulates NF?B and microRNA-155 in macrophages to control the inflammatory response. Proc Natl Acad Sci U S A. 2016 Feb 02; 113(5):1369-74. Mantuano E, Brifault C, Lam MS, Azmoon P, Gilder AS, Gonias SL. PMID: 26787872.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    26. Selective coexpression of VEGF receptor 2 in EGFRvIII-positive glioblastoma cells prevents cellular senescence and contributes to their aggressive nature. Neuro Oncol. 2016 05; 18(5):667-78. Jones KA, Gilder AS, Lam MS, Du N, Banki MA, Merati A, Pizzo DP, VandenBerg SR, Gonias SL. PMID: 26420897.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    27. The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration. J Cell Sci. 2015 Sep 15; 128(18):3478-88. Mantuano E, Lam MS, Shibayama M, Campana WM, Gonias SL. PMID: 26272917.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    28. Urokinase receptor and resistance to targeted anticancer agents. Front Pharmacol. 2015; 6:154. Gonias SL, Hu J. PMID: 26283964.
      View in: PubMed   Mentions:
    29. Soluble Urokinase Receptor Is Released Selectively by Glioblastoma Cells That Express Epidermal Growth Factor Receptor Variant III and Promotes Tumor Cell Migration and Invasion. J Biol Chem. 2015 Jun 12; 290(24):14798-809. Gilder AS, Jones KA, Hu J, Wang L, Chen CC, Carter BS, Gonias SL. PMID: 25837250.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    30. A urokinase receptor-Bim signaling axis emerges during EGFR inhibitor resistance in mutant EGFR glioblastoma. Cancer Res. 2015 Jan 15; 75(2):394-404. Wykosky J, Hu J, Gomez GG, Taylor T, Villa GR, Pizzo D, VandenBerg SR, Thorne AH, Chen CC, Mischel PS, Gonias SL, Cavenee WK, Furnari FB. PMID: 25432173.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    31. uPAR induces expression of transforming growth factor ß and interleukin-4 in cancer cells to promote tumor-permissive conditioning of macrophages. Am J Pathol. 2014 Dec; 184(12):3384-93. Hu J, Jo M, Eastman BM, Gilder AS, Bui JD, Gonias SL. PMID: 25310970.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    32. Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation. Mol Cell Proteomics. 2015 Jan; 14(1):1-14. Pasillas MP, Shields S, Reilly R, Strnadel J, Behl C, Park R, Yates JR, Klemke R, Gonias SL, Coppinger JA. PMID: 24997994.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    33. Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties. J Clin Invest. 2014 Mar; 124(3):1199-213. Demeule M, Beaudet N, Régina A, Besserer-Offroy É, Murza A, Tétreault P, Belleville K, Ché C, Larocque A, Thiot C, Béliveau R, Longpré JM, Marsault É, Leduc R, Lachowicz JE, Gonias SL, Castaigne JP, Sarret P. PMID: 24531547.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    34. Mammalian target of rapamycin complex 2 (mTORC2) is a critical determinant of bladder cancer invasion. PLoS One. 2013; 8(11):e81081. Gupta S, Hau AM, Beach JR, Harwalker J, Mantuano E, Gonias SL, Egelhoff TT, Hansel DE. PMID: 24312263.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    35. LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein. J Biol Chem. 2013 Nov 22; 288(47):34009-34018. Mantuano E, Lam MS, Gonias SL. PMID: 24129569.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    36. LDL receptor-related protein-1: a regulator of inflammation in atherosclerosis, cancer, and injury to the nervous system. Am J Pathol. 2014 Jan; 184(1):18-27. Gonias SL, Campana WM. PMID: 24128688.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimals
    37. Myeloid cell receptor LRP1/CD91 regulates monocyte recruitment and angiogenesis in tumors. Cancer Res. 2013 Jul 01; 73(13):3902-12. Staudt ND, Jo M, Hu J, Bristow JM, Pizzo DP, Gaultier A, VandenBerg SR, Gonias SL. PMID: 23633492.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    38. Schwann cell LRP1 regulates remak bundle ultrastructure and axonal interactions to prevent neuropathic pain. J Neurosci. 2013 Mar 27; 33(13):5590-602. Orita S, Henry K, Mantuano E, Yamauchi K, De Corato A, Ishikawa T, Feltri ML, Wrabetz L, Gaultier A, Pollack M, Ellisman M, Takahashi K, Gonias SL, Campana WM. PMID: 23536074.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    39. Identification of the low density lipoprotein (LDL) receptor-related protein-1 interactome in central nervous system myelin suggests a role in the clearance of necrotic cell debris. J Biol Chem. 2013 Feb 15; 288(7):4538-48. Fernandez-Castaneda A, Arandjelovic S, Stiles TL, Schlobach RK, Mowen KA, Gonias SL, Gaultier A. PMID: 23264627.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    40. LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin. J Cell Sci. 2013 Jan 01; 126(Pt 1):209-20. Stiles TL, Dickendesher TL, Gaultier A, Fernandez-Castaneda A, Mantuano E, Giger RJ, Gonias SL. PMID: 23132925.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    41. Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover. J Biol Chem. 2013 Jan 04; 288(1):123-31. Bristow JM, Reno TA, Jo M, Gonias SL, Klemke RL. PMID: 23105102.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    42. A transformation in the mechanism by which the urokinase receptor signals provides a selection advantage for estrogen receptor-expressing breast cancer cells in the absence of estrogen. Cell Signal. 2012 Sep; 24(9):1847-55. Eastman BM, Jo M, Webb DL, Takimoto S, Gonias SL. PMID: 22617030.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    43. The unfolded protein response is a major mechanism by which LRP1 regulates Schwann cell survival after injury. J Neurosci. 2011 Sep 21; 31(38):13376-85. Mantuano E, Henry K, Yamauchi T, Hiramatsu N, Yamauchi K, Orita S, Takahashi K, Lin JH, Gonias SL, Campana WM. PMID: 21940431.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    44. Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15984-9. Hu J, Jo M, Cavenee WK, Furnari F, VandenBerg SR, Gonias SL. PMID: 21896743.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    45. Maspin, the molecular bridge between the plasminogen activator system and beta1 integrin that facilitates cell adhesion. J Biol Chem. 2011 Jul 15; 286(28):24599-607. Endsley MP, Hu Y, Deng Y, He X, Warejcka DJ, Twining SS, Gonias SL, Zhang M. PMID: 21606500.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    46. Regulation of cytokine expression by Schwann cells in response to a2-macroglobulin binding to LRP1. J Neurosci Res. 2011 Apr; 89(4):544-51. Shi Y, Yamauchi T, Gaultier A, Takimoto S, Campana WM, Gonias SL. PMID: 21290408.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    47. Regulation of the urokinase receptor (uPAR) by LDL receptor-related protein-1 (LRP1). Curr Pharm Des. 2011; 17(19):1962-9. Gonias SL, Gaultier A, Jo M. PMID: 21711236.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    48. LDL receptor-related protein 1 regulates the abundance of diverse cell-signaling proteins in the plasma membrane proteome. J Proteome Res. 2010 Dec 03; 9(12):6689-95. Gaultier A, Simon G, Niessen S, Dix M, Takimoto S, Cravatt BF, Gonias SL. PMID: 20919742.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    49. Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells. Cancer Res. 2010 Nov 01; 70(21):8948-58. Jo M, Eastman BM, Webb DL, Stoletov K, Klemke R, Gonias SL. PMID: 20940399.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    50. Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages. J Leukoc Biol. 2010 Oct; 88(4):769-78. Gorovoy M, Gaultier A, Campana WM, Firestein GS, Gonias SL. PMID: 20610799.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    51. Factor XII bridges coagulation and fibrinolysis again. Blood. 2010 Jun 17; 115(24):4979-80. Gonias SL. PMID: 20558624.
      View in: PubMed   Mentions:    Fields:    
    52. Low density lipoprotein receptor-related protein (LRP1) regulates Rac1 and RhoA reciprocally to control Schwann cell adhesion and migration. J Biol Chem. 2010 May 07; 285(19):14259-66. Mantuano E, Jo M, Gonias SL, Campana WM. PMID: 20197276.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    53. Chemoattractant signaling between tumor cells and macrophages regulates cancer cell migration, metastasis and neovascularization. PLoS One. 2009 Aug 21; 4(8):e6713. Green CE, Liu T, Montel V, Hsiao G, Lester RD, Subramaniam S, Gonias SL, Klemke RL. PMID: 19696929.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    54. LRP1 regulates remodeling of the extracellular matrix by fibroblasts. Matrix Biol. 2010 Jan; 29(1):22-30. Gaultier A, Hollister M, Reynolds I, Hsieh EH, Gonias SL. PMID: 19699300.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    55. Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling. J Biol Chem. 2009 Aug 21; 284(34):22825-33. Jo M, Lester RD, Montel V, Eastman B, Takimoto S, Gonias SL. PMID: 19546228.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    56. The urokinase receptor promotes cancer metastasis independently of urokinase-type plasminogen activator in mice. Am J Pathol. 2009 Jul; 175(1):190-200. Jo M, Takimoto S, Montel V, Gonias SL. PMID: 19497996.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    57. Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway. Sci Signal. 2009 Apr 28; 2(68):ra18. Shi Y, Mantuano E, Inoue G, Campana WM, Gonias SL. PMID: 19401592.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    58. Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis. J Cell Sci. 2009 Apr 15; 122(Pt 8):1155-62. Gaultier A, Wu X, Le Moan N, Takimoto S, Mukandala G, Akassoglou K, Campana WM, Gonias SL. PMID: 19299462.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    59. The hemopexin domain of matrix metalloproteinase-9 activates cell signaling and promotes migration of schwann cells by binding to low-density lipoprotein receptor-related protein. J Neurosci. 2008 Nov 05; 28(45):11571-82. Mantuano E, Inoue G, Li X, Takahashi K, Gaultier A, Gonias SL, Campana WM. PMID: 18987193.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    60. Binding of alpha2ML1 to the low density lipoprotein receptor-related protein 1 (LRP1) reveals a new role for LRP1 in the human epidermis. PLoS One. 2008 Jul 23; 3(7):e2729. Galliano MF, Toulza E, Jonca N, Gonias SL, Serre G, Guerrin M. PMID: 18648652.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    61. Urokinase: the identity crisis continues. Blood. 2008 Jul 01; 112(1):8. Gonias SL. PMID: 18574039.
      View in: PubMed   Mentions:    Fields:    
    62. Molecular dissection of the human alpha2-macroglobulin subunit reveals domains with antagonistic activities in cell signaling. J Biol Chem. 2008 Jul 18; 283(29):19904-11. Mantuano E, Mukandala G, Li X, Campana WM, Gonias SL. PMID: 18499670.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    63. Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor. Blood. 2008 Jun 01; 111(11):5316-25. Gaultier A, Arandjelovic S, Niessen S, Overton CD, Linton MF, Fazio S, Campana WM, Cravatt BF, Gonias SL. PMID: 18369152.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    64. A shed form of LDL receptor-related protein-1 regulates peripheral nerve injury and neuropathic pain in rodents. J Clin Invest. 2008 Jan; 118(1):161-72. Gaultier A, Arandjelovic S, Li X, Janes J, Dragojlovic N, Zhou GP, Dolkas J, Myers RR, Gonias SL, Campana WM. PMID: 18060043.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    65. High-resolution imaging of the dynamic tumor cell vascular interface in transparent zebrafish. Proc Natl Acad Sci U S A. 2007 Oct 30; 104(44):17406-11. Stoletov K, Montel V, Lester RD, Gonias SL, Klemke R. PMID: 17954920.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansAnimalsCells
    66. The low-density lipoprotein receptor-related protein regulates cancer cell survival and metastasis development. Cancer Res. 2007 Oct 15; 67(20):9817-24. Montel V, Gaultier A, Lester RD, Campana WM, Gonias SL. PMID: 17942912.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    67. Autoantibodies in canine masticatory muscle myositis recognize a novel myosin binding protein-C family member. J Immunol. 2007 Oct 01; 179(7):4939-44. Wu X, Li ZF, Brooks R, Komives EA, Torpey JW, Engvall E, Gonias SL, Shelton GD. PMID: 17878394.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
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    75. Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression. J Biol Chem. 2006 Jan 27; 281(4):2120-7. Hu K, Yang J, Tanaka S, Gonias SL, Mars WM, Liu Y. PMID: 16303771.
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    76. Erythropoietin promotes MCF-7 breast cancer cell migration by an ERK/mitogen-activated protein kinase-dependent pathway and is primarily responsible for the increase in migration observed in hypoxia. J Biol Chem. 2005 Nov 25; 280(47):39273-7. Lester RD, Jo M, Campana WM, Gonias SL. PMID: 16207704.
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    77. Schwann cells express erythropoietin receptor and represent a major target for Epo in peripheral nerve injury. Glia. 2005 Sep; 51(4):254-65. Li X, Gonias SL, Campana WM. PMID: 15812815.
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    78. Activation of hepatocyte growth factor by urokinase-type plasminogen activator is ionic strength-dependent. Biochem J. 2005 Aug 15; 390(Pt 1):311-5. Mars WM, Jo M, Gonias SL. PMID: 15869463.
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    80. A chemically modified preparation of alpha2-macroglobulin binds beta-amyloid peptide with increased affinity and inhibits Abeta cytotoxicity. J Neurochem. 2005 Apr; 93(1):53-62. Mettenburg JM, Arandjelovic S, Gonias SL. PMID: 15773905.
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    81. Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator. J Biol Chem. 2005 Apr 29; 280(17):17449-57. Jo M, Thomas KS, Marozkina N, Amin TJ, Silva CM, Parsons SJ, Gonias SL. PMID: 15728176.
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    82. Beta-amyloid peptide binds equivalently to binary and ternary alpha2-macroglobulin-protease complexes. Protein J. 2005 Feb; 24(2):89-93. Mettenburg JM, Gonias SL. PMID: 16003950.
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    86. Functional analysis of plasma alpha(2)-macroglobulin from Alzheimer's disease patients with the A2M intronic deletion. Neurobiol Dis. 2003 Dec; 14(3):504-12. Hope C, Mettenburg J, Gonias SL, DeKosky ST, Kamboh MI, Chu CT. PMID: 14678766.
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    87. Soluble urokinase-type plasminogen activator receptor inhibits cancer cell growth and invasion by direct urokinase-independent effects on cell signaling. J Biol Chem. 2003 Nov 21; 278(47):46692-8. Jo M, Thomas KS, Wu L, Gonias SL. PMID: 12963722.
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    88. Comparison of diagnostic accuracies in outpatients and hospitalized patients of D-dimer testing for the evaluation of suspected pulmonary embolism. Clin Chem. 2003 Sep; 49(9):1483-90. Schrecengost JE, LeGallo RD, Boyd JC, Moons KG, Gonias SL, Rose CE, Bruns DE. PMID: 12928229.
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    89. Characterization of the interaction between alpha2-macroglobulin and fibroblast growth factor-2: the role of hydrophobic interactions. Biochem J. 2003 Aug 15; 374(Pt 1):123-9. Mathew S, Arandjelovic S, Beyer WF, Gonias SL, Pizzo SV. PMID: 12755687.
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    90. Growth factor-binding sequence in human alpha2-macroglobulin targets the receptor-binding site in transforming growth factor-beta. Biochemistry. 2003 May 27; 42(20):6121-7. Arandjelovic S, Freed TA, Gonias SL. PMID: 12755614.
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    92. Epidermal growth factor receptor-dependent and -independent cell-signaling pathways originating from the urokinase receptor. J Biol Chem. 2003 Jan 17; 278(3):1642-6. Jo M, Thomas KS, O'Donnell DM, Gonias SL. PMID: 12426305.
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    93. Diverse roles for the LDL receptor family. Trends Endocrinol Metab. 2002 Mar; 13(2):66-74. Strickland DK, Gonias SL, Argraves WS. PMID: 11854021.
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    94. The low density lipoprotein receptor-related protein mediates fibronectin catabolism and inhibits fibronectin accumulation on cell surfaces. J Biol Chem. 2002 May 03; 277(18):16160-6. Salicioni AM, Mizelle KS, Loukinova E, Mikhailenko I, Strickland DK, Gonias SL. PMID: 11867643.
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    95. Distinct binding sites in the structure of alpha 2-macroglobulin mediate the interaction with beta-amyloid peptide and growth factors. J Biol Chem. 2002 Apr 12; 277(15):13338-45. Mettenburg JM, Webb DJ, Gonias SL. PMID: 11823454.
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    96. Cooperativity between the Ras-ERK and Rho-Rho kinase pathways in urokinase-type plasminogen activator-stimulated cell migration. J Biol Chem. 2002 Apr 05; 277(14):12479-85. Jo M, Thomas KS, Somlyo AV, Somlyo AP, Gonias SL. PMID: 11805108.
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