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Andrew Lowy

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentSurgery
Address9500 Gilman Drive #0987
La Jolla CA 92093
Phone858-822-2124
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    Collapse Overview 
    Collapse Overview
    Dr. Andrew M. Lowy is a surgical oncologist with a primary interest in cancers of the pancreas, liver and GI tract. He has a specialty interest in the management of patients with metastatic disease to the liver and peritoneum.

    Dr. Lowy is recognized worldwide for his expertise in the surgical treatment of pancreatic cancer and for investigating novel cancer treatments which incorporate surgery and chemotherapy to treat patients with advanced cancer that has spread to the abdomen. He has furthered the development of a promising treatment known as the “chemo bath” or heated intraperitoneal chemotherapy (HIPEC), to treat advanced abdominal cancers. During surgery, all visible signs of tumor are removed, and a heated chemotherapy solution is circulated throughout the abdomen for up to 90 minutes. The solution is then removed and the incision closed.

    Dr. Lowy serves on the editorial boards of the Journal of Clinical Oncology and the Annals of Surgical Oncology . He also serves as surgical liaison to the Pancreas and Hepatobiliary Committee of the Southwest Oncology Group (SWOG), which is one of the largest National Cancer Institute cooperative groups. Recently, Dr. Lowy was selected to co-chair the National Cancer Institute’s Pancreatic Cancer Task Force which is charged with setting the direction of clinical research in pancreatic cancer in the United States. He has conducted extensive research in gastrointestinal and pancreatic cancer with funding from the National Cancer Institute.

    Research Overview
    Our work is focused on the study of pancreatic carcinogenesis and therapy. More specifically, we focus on the study of the RON receptor tyrosine kinase and its role in disease pathogenesis and as a potential therapeutic target. We are also extensively involved in model development and testing of novel therapeutics.

    Research Topics
    - Cancer
    - Molecular Biology
    - Translational Research

    Current Project Titles
    - The RON Receptor in Pancreatic Cancer Biology and Therapy
    - The iRGD peptide to enhance drug delivery and efficacy in pancreatic cancer


    Collapse Research 
    Collapse Research Activities and Funding
    Musashi-mediated control of pancreatic cancer growth and progression
    NIH/NCI R01CA186043Feb 1, 2015 - Jan 31, 2020
    Role: Principal Investigator
    GPCRs: novel targets in cancer-associated fibroblasts
    NIH/NCI R21CA189477Jul 1, 2014 - Jun 30, 2016
    Role: Principal Investigator
    RON Receptor in Pancreatic Cancer Biology and Therapy
    NIH/NCI R01CA155620Sep 22, 2011 - May 31, 2022
    Role: Principal Investigator
    Targeting RON Receptor Signaling in Pancreatic Cancer
    NIH/NCI R21CA137692Jul 1, 2009 - Jun 30, 2011
    Role: Principal Investigator
    Gene Targets of Wnt Signaling in Pancreatic Cancer
    NIH/NCI K08CA089403Jul 1, 2001 - Jun 30, 2006
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Baumgartner JM, Raymond VM, Lanman RB, Tran L, Kelly KJ, Lowy A, Kurzrock R. Preoperative Circulating Tumor DNA in Patients with Peritoneal Carcinomatosis is an Independent Predictor of Progression-Free Survival. Ann Surg Oncol. 2018 Jun 14. PMID: 29948422.
      View in: PubMed
    2. Insel PA, Sriram K, Wiley SZ, Wilderman A, Katakia T, McCann T, Yokouchi H, Zhang L, Corriden R, Liu D, Feigin ME, French RP, Lowy A, Murray F. GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic Targets. Front Pharmacol. 2018; 9:431. PMID: 29872392.
      View in: PubMed
    3. Scully KM, Lahmy R, Signaevskaia L, Sasik R, Medal R, Kim H, French R, James B, Wu Y, Lowy A, Itkin-Ansari P. E47 Governs the MYC-CDKN1B/p27KIP1-RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16INK4A and Wild-Type p53. Cell Mol Gastroenterol Hepatol. 2018; 6(2):181-198. PMID: 30003124.
      View in: PubMed
    4. Weiss A, Ward EP, Baumgartner JM, Lowy A, Kelly KJ. Cirrhosis is not a contraindication to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in highly selected patients. World J Surg Oncol. 2018 Apr 26; 16(1):87. PMID: 29699564.
      View in: PubMed
    5. Wiley SZ, Sriram K, Liang W, Chang SE, French R, McCann T, Sicklick J, Nishihara H, Lowy A, Insel PA. GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells. FASEB J. 2018 Mar; 32(3):1170-1183. PMID: 29092903.
      View in: PubMed
    6. Reghunathan M, Kelly KJ, Valasek MA, Lowy A, Baumgartner JM. Histologic Predictors of Recurrence in Mucinous Appendiceal Tumors with Peritoneal Dissemination after HIPEC. Ann Surg Oncol. 2018 Mar; 25(3):702-708. PMID: 29282599.
      View in: PubMed
    7. Saison-Ridinger M, DelGiorno KE, Zhang T, Kraus A, French R, Jaquish D, Tsui C, Erikson G, Spike BT, Shokhirev MN, Liddle C, Yu RT, Downes M, Evans RM, Saghatelian A, Lowy A, Wahl GM. Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy. PLoS One. 2017; 12(12):e0189051. PMID: 29211796.
      View in: PubMed
    8. White RR, Lowy A. Clinical Management: Resectable Disease. Cancer J. 2017 Nov/Dec; 23(6):343-349. PMID: 29189330.
      View in: PubMed
    9. Kelly KJ, Cajas L, Baumgartner JM, Lowy A. Factors Associated with 60-Day Readmission Following Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy. Ann Surg Oncol. 2018 Jan; 25(1):91-97. PMID: 29090402.
      View in: PubMed
    10. Berlin JD, Feng Y, Catalano P, Abbruzzese JL, Philip PA, McWilliams RR, Lowy A, Benson AB, Blackstock AW. An Intergroup Randomized Phase II Study of Bevacizumab or Cetuximab in Combination with Gemcitabine and in Combination with Chemoradiation in Patients with Resected Pancreatic Carcinoma: A Trial of the ECOG-ACRIN Cancer Research Group (E2204). Oncology. 2018; 94(1):39-46. PMID: 29040974.
      View in: PubMed
    11. Baumgartner JM, McKenzie S, Block S, Costantini TW, Lowy A. Prophylactic enoxaparin doses may be inadequate in patients undergoing abdominal cancer surgery. J Surg Res. 2018 Jan; 221:183-189. PMID: 29229126.
      View in: PubMed
    12. Tempero MA, Malafa MP, Al-Hawary M, Asbun H, Bain A, Behrman SW, Benson AB, Binder E, Cardin DB, Cha C, Chiorean EG, Chung V, Czito B, Dillhoff M, Dotan E, Ferrone CR, Hardacre J, Hawkins WG, Herman J, Ko AH, Komanduri S, Koong A, LoConte N, Lowy A, Moravek C, Nakakura EK, O'Reilly EM, Obando J, Reddy S, Scaife C, Thayer S, Weekes CD, Wolff RA, Wolpin BM, Burns J, Darlow S. Pancreatic Adenocarcinoma, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2017 Aug; 15(8):1028-1061. PMID: 28784865.
      View in: PubMed
    13. Villarino N, Signaevskaia L, van Niekerk J, Medal R, Kim H, Lahmy R, Scully K, Pinkerton A, Kim S, Lowy A, Itkin-Ansari P. A screen for inducers of bHLH activity identifies pitavastatin as a regulator of p21, Rb phosphorylation and E2F target gene expression in pancreatic cancer. Oncotarget. 2017 Aug 08; 8(32):53154-53167. PMID: 28881801.
      View in: PubMed
    14. Milette S, Sicklick JK, Lowy A, Brodt P. Molecular Pathways: Targeting the Microenvironment of Liver Metastases. Clin Cancer Res. 2017 Nov 01; 23(21):6390-6399. PMID: 28615370.
      View in: PubMed
    15. Valasek MA, Thung I, Gollapalle E, Hodkoff AA, Kelly KJ, Baumgartner JM, Vavinskaya V, Lin GY, Tipps AP, Hosseini MV, Lowy A. Overinterpretation is common in pathological diagnosis of appendix cancer during patient referral for oncologic care. PLoS One. 2017; 12(6):e0179216. PMID: 28591173.
      View in: PubMed
    16. Ikemoto H, Lingasamy P, Anton Willmore AM, Hunt H, Kurm K, Tammik O, Scodeller P, Simón-Gracia L, Kotamraju VR, Lowy A, Sugahara KN, Teesalu T. Hyaluronan-binding peptide for targeting peritoneal carcinomatosis. Tumour Biol. 2017 May; 39(5):1010428317701628. PMID: 28468593.
      View in: PubMed
    17. Chung V, McDonough S, Philip PA, Cardin D, Wang-Gillam A, Hui L, Tejani MA, Seery TE, Dy IA, Al Baghdadi T, Hendifar AE, Doyle LA, Lowy A, Guthrie KA, Blanke CD, Hochster HS. Effect of Selumetinib and MK-2206 vs Oxaliplatin and Fluorouracil in Patients With Metastatic Pancreatic Cancer After Prior Therapy: SWOG S1115 Study Randomized Clinical Trial. JAMA Oncol. 2017 Apr 01; 3(4):516-522. PMID: 27978579.
      View in: PubMed
    18. Meredith RF, Torgue JJ, Rozgaja TA, Banaga EP, Bunch PW, Alvarez RD, Straughn JM, Dobelbower MC, Lowy A. Safety and Outcome Measures of First-in-Human Intraperitoneal a Radioimmunotherapy With 212Pb-TCMC-Trastuzumab. Am J Clin Oncol. 2016 Nov 30. PMID: 27906723.
      View in: PubMed
    19. Katz MH, Shi Q, Ahmad SA, Herman JM, Marsh Rde W, Collisson E, Schwartz L, Frankel W, Martin R, Conway W, Truty M, Kindler H, Lowy A, Bekaii-Saab T, Philip P, Talamonti M, Cardin D, LoConte N, Shen P, Hoffman JP, Venook AP. Preoperative Modified FOLFIRINOX Treatment Followed by Capecitabine-Based Chemoradiation for Borderline Resectable Pancreatic Cancer: Alliance for Clinical Trials in Oncology Trial A021101. JAMA Surg. 2016 08 17; 151(8):e161137. PMID: 27275632.
      View in: PubMed
    20. Chakedis J, French R, Babicky M, Jaquish D, Mose E, Cheng P, Holman P, Howard H, Miyamoto J, Porras P, Walterscheid Z, Schultz-Fademrecht C, Esdar C, Schadt O, Eickhoff J, Lowy A. Characterization of RON protein isoforms in pancreatic cancer: implications for biology and therapeutics. Oncotarget. 2016 Jul 19; 7(29):45959-45975. PMID: 27323855.
      View in: PubMed
    21. Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp J, Kritzik M, Sicklick J, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek M, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy A, Reya T. Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Nature. 2016 06 16; 534(7607):407-411. PMID: 27281208; PMCID: PMC4998062 [Available on 12/16/16].
    22. Kaneda MM, Cappello P, Nguyen AV, Ralainirina N, Hardamon CR, Foubert P, Schmid MC, Sun P, Mose E, Bouvet M, Lowy A, Valasek MA, Sasik R, Novelli F, Hirsch E, Varner JA. Macrophage PI3K? Drives Pancreatic Ductal Adenocarcinoma Progression. Cancer Discov. 2016 08; 6(8):870-85. PMID: 27179037.
      View in: PubMed
    23. Principe DR, DeCant B, Diaz AM, Mangan RJ, Hwang R, Lowy A, Shetuni BB, Sreekumar BK, Chung C, Bentrem DJ, Munshi HG, Jung B, Grippo PJ, Bishehsari F. PEDF inhibits pancreatic tumorigenesis by attenuating the fibro-inflammatory reaction. Oncotarget. 2016 May 10; 7(19):28218-34. PMID: 27058416.
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    24. Braun GB, Sugahara KN, Yu OM, Kotamraju VR, Mölder T, Lowy A, Ruoslahti E, Teesalu T. Urokinase-controlled tumor penetrating peptide. J Control Release. 2016 06 28; 232:188-95. PMID: 27106816.
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    25. Yeo D, He H, Patel O, Lowy A, Baldwin GS, Nikfarjam M. FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine. BMC Cancer. 2016 Jan 16; 16:24. PMID: 26774265; PMCID: PMC4715347.
    26. Baumgartner JM, Kwong TG, Ma GL, Messer K, Kelly KJ, Lowy A. A Novel Tool for Predicting Major Complications After Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy. Ann Surg Oncol. 2016 May; 23(5):1609-17. PMID: 26678406.
      View in: PubMed
    27. Marmor RA, Kelly KJ, Lowy A, Baumgartner JM. Laparoscopy is Safe and Accurate to Evaluate Peritoneal Surface Metastasis Prior to Cytoreductive Surgery. Ann Surg Oncol. 2016 May; 23(5):1461-7. PMID: 26542584.
      View in: PubMed
    28. Sugahara KN, Scodeller P, Braun GB, de Mendoza TH, Yamazaki CM, Kluger MD, Kitayama J, Alvarez E, Howell SB, Teesalu T, Ruoslahti E, Lowy A. A tumor-penetrating peptide enhances circulation-independent targeting of peritoneal carcinomatosis. J Control Release. 2015 Aug 28; 212:59-69. PMID: 26071630; PMCID: PMC4508207.
    29. Ben-Josef E, Guthrie KA, El-Khoueiry AB, Corless CL, Zalupski MM, Lowy A, Thomas CR, Alberts SR, Dawson LA, Micetich KC, Thomas MB, Siegel AB, Blanke CD. SWOG S0809: A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma. J Clin Oncol. 2015 Aug 20; 33(24):2617-22. PMID: 25964250; PMCID: PMC4534524.
    30. Heestand GM, Murphy JD, Lowy A. Approach to patients with pancreatic cancer without detectable metastases. J Clin Oncol. 2015 Jun 01; 33(16):1770-8. PMID: 25918279.
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    31. Alakus H, Yost SE, Woo B, French R, Lin GY, Jepsen K, Frazer KA, Lowy A, Harismendy O. BAP1 mutation is a frequent somatic event in peritoneal malignant mesothelioma. J Transl Med. 2015 Apr 16; 13:122. PMID: 25889843; PMCID: PMC4422481.
    32. Buckel L, Savariar EN, Crisp JL, Jones KA, Hicks AM, Scanderbeg DJ, Nguyen QT, Sicklick JK, Lowy A, Tsien RY, Advani SJ. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 01; 75(7):1376-1387. PMID: 25681274; PMCID: PMC4458508.
    33. Lopez NE, Peterson CY, Ramamoorthy SL, McLemore EC, Sedrak MF, Lowy A, Horgan S, Talamini MA, Sicklick JK. Single-incision laparoscopic surgery through an ostomy site: a natural approach by an unnatural orifice. Surg Laparosc Endosc Percutan Tech. 2015 Feb; 25(1):74-8. PMID: 24743670.
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    34. Kelly KJ, Baumgartner JM, Lowy A. Laparoscopic evacuation of mucinous ascites for palliation of pseudomyxoma peritonei. Ann Surg Oncol. 2015 May; 22(5):1722-5. PMID: 25395145.
      View in: PubMed
    35. Sugahara KN, Braun GB, de Mendoza TH, Kotamraju VR, French RP, Lowy A, Teesalu T, Ruoslahti E. Tumor-penetrating iRGD peptide inhibits metastasis. Mol Cancer Ther. 2015 Jan; 14(1):120-8. PMID: 25392370.
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    36. Schönhuber N, Seidler B, Schuck K, Veltkamp C, Schachtler C, Zukowska M, Eser S, Feyerabend TB, Paul MC, Eser P, Klein S, Lowy A, Banerjee R, Yang F, Lee CL, Moding EJ, Kirsch DG, Scheideler A, Alessi DR, Varela I, Bradley A, Kind A, Schnieke AE, Rodewald HR, Rad R, Schmid RM, Schneider G, Saur D. A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. Nat Med. 2014 Nov; 20(11):1340-1347. PMID: 25326799; PMCID: PMC4270133.
    37. Wilson GC, Sutton JM, Abbott DE, Smith MT, Lowy A, Matthews JB, Rilo HL, Schmulewitz N, Salehi M, Choe K, Brunner J, Hanseman DJ, Sussman JJ, Edwards MJ, Ahmad SA. Long-term outcomes after total pancreatectomy and islet cell autotransplantation: is it a durable operation? Ann Surg. 2014 Oct; 260(4):659-65; discussion 665-7. PMID: 25203883.
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    38. Fujimura K, Wright T, Strnadel J, Kaushal S, Metildi C, Lowy A, Bouvet M, Kelber JA, Klemke RL. A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer. Cancer Res. 2014 Nov 15; 74(22):6671-81. PMID: 25261239; PMCID: PMC4233190.
    39. Baumgartner JM, Tobin L, Heavey SF, Kelly KJ, Roeland EJ, Lowy A. Predictors of progression in high-grade appendiceal or colorectal peritoneal carcinomatosis after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Ann Surg Oncol. 2015 May; 22(5):1716-21. PMID: 25145504.
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    40. Lopez NE, Prendergast C, Lowy A. Borderline resectable pancreatic cancer: definitions and management. World J Gastroenterol. 2014 Aug 21; 20(31):10740-51. PMID: 25152577; PMCID: PMC4138454.
    41. Prada-Villaverde A, Esquivel J, Lowy A, Markman M, Chua T, Pelz J, Baratti D, Baumgartner JM, Berri R, Bretcha-Boix P, Deraco M, Flores-Ayala G, Glehen O, Gomez-Portilla A, González-Moreno S, Goodman M, Halkia E, Kusamura S, Moller M, Passot G, Pocard M, Salti G, Sardi A, Senthil M, Spiliotis J, Torres-Melero J, Turaga K, Trout R. The American Society of Peritoneal Surface Malignancies evaluation of HIPEC with Mitomycin C versus Oxaliplatin in 539 patients with colon cancer undergoing a complete cytoreductive surgery. J Surg Oncol. 2014 Dec; 110(7):779-85. PMID: 25088304.
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    42. Tempero MA, Malafa MP, Behrman SW, Benson AB, Casper ES, Chiorean EG, Chung V, Cohen SJ, Czito B, Engebretson A, Feng M, Hawkins WG, Herman J, Hoffman JP, Ko A, Komanduri S, Koong A, Lowy A, Ma WW, Merchant NB, Mulvihill SJ, Muscarella P, Nakakura EK, Obando J, Pitman MB, Reddy S, Sasson AR, Thayer SP, Weekes CD, Wolff RA, Wolpin BM, Burns JL, Freedman-Cass DA. Pancreatic adenocarcinoma, version 2.2014: featured updates to the NCCN guidelines. J Natl Compr Canc Netw. 2014 Aug; 12(8):1083-93. PMID: 25099441.
      View in: PubMed
    43. Alakus H, Babicky ML, Ghosh P, Yost S, Jepsen K, Dai Y, Arias A, Samuels ML, Mose ES, Schwab RB, Peterson MR, Lowy A, Frazer KA, Harismendy O. Correction: Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin. Genome Med. 2014; 6(7):53. PMID: 25228923; PMCID: PMC4165363.
    44. Philip PA, Goldman B, Ramanathan RK, Lenz HJ, Lowy A, Whitehead RP, Wakatsuki T, Iqbal S, Gaur R, Benedetti JK, Blanke CD. Dual blockade of epidermal growth factor receptor and insulin-like growth factor receptor-1 signaling in metastatic pancreatic cancer: phase Ib and randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib (SWOG S0727). Cancer. 2014 Oct 01; 120(19):2980-5. PMID: 25041791; PMCID: PMC4284963.
    45. Alakus H, Bollschweiler E, Hölscher AH, Warnecke-Eberz U, Frazer KA, Harismendy O, Lowy A, Mönig SP, Eberz PM, Maus M, Drebber U, Siffert W, Metzger R. Homozygous GNAS 393C-allele carriers with locally advanced esophageal cancer fail to benefit from platinum-based preoperative chemoradiotherapy. Ann Surg Oncol. 2014 Dec; 21(13):4375-82. PMID: 24986238.
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    46. Alakus H, Babicky ML, Ghosh P, Yost S, Jepsen K, Dai Y, Arias A, Samuels ML, Mose ES, Schwab RB, Peterson MR, Lowy A, Frazer KA, Harismendy O. Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin. Genome Med. 2014; 6(5):43. PMID: 24944587; PMCID: PMC4062050.
    47. Esquivel J, Lowy A, Markman M, Chua T, Pelz J, Baratti D, Baumgartner JM, Berri R, Bretcha-Boix P, Deraco M, Flores-Ayala G, Glehen O, Gomez-Portilla A, González-Moreno S, Goodman M, Halkia E, Kusamura S, Moller M, Passot G, Pocard M, Salti G, Sardi A, Senthil M, Spilioitis J, Torres-Melero J, Turaga K, Trout R. The American Society of Peritoneal Surface Malignancies (ASPSM) Multiinstitution Evaluation of the Peritoneal Surface Disease Severity Score (PSDSS) in 1,013 Patients with Colorectal Cancer with Peritoneal Carcinomatosis. Ann Surg Oncol. 2014 Dec; 21(13):4195-201. PMID: 24854493.
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    48. Seguin L, Kato S, Franovic A, Camargo MF, Lesperance J, Elliott KC, Yebra M, Mielgo A, Lowy A, Husain H, Cascone T, Diao L, Wang J, Wistuba II, Heymach JV, Lippman SM, Desgrosellier JS, Anand S, Weis SM, Cheresh DA. An integrin ß3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition. Nat Cell Biol. 2014 May; 16(5):457-68. PMID: 24747441.
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    49. Tran Cao HS, Lopez N, Chang DC, Lowy A, Bouvet M, Baumgartner JM, Talamini MA, Sicklick JK. Improved perioperative outcomes with minimally invasive distal pancreatectomy: results from a population-based analysis. JAMA Surg. 2014 Mar; 149(3):237-43. PMID: 24402232; PMCID: PMC4383084.
    50. Kang CM, Babicky ML, Lowy A. The RON receptor tyrosine kinase in pancreatic cancer pathogenesis and its potential implications for future targeted therapies. Pancreas. 2014 Mar; 43(2):183-9. PMID: 24518495; PMCID: PMC4009395.
    51. Sicklick JK, Leonard SY, Babicky ML, Tang CM, Mose ES, French RP, Jaquish DV, Hoh CK, Peterson M, Schwab R, Lowy A. Generation of orthotopic patient-derived xenografts from gastrointestinal stromal tumor. J Transl Med. 2014 Feb 10; 12:41. PMID: 24507750; PMCID: PMC3930355.
    52. Kwong WT, Fehmi SM, Lowy A, Savides TJ. Enteral stenting for gastric outlet obstruction and afferent limb syndrome following pancreaticoduodenectomy. Ann Gastroenterol. 2014; 27(4):413-417. PMID: 25332208.
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    53. Snyder CS, Harrington AR, Kaushal S, Mose E, Lowy A, Hoffman RM, Bouvet M. A dual-color genetically engineered mouse model for multispectral imaging of the pancreatic microenvironment. Pancreas. 2013 Aug; 42(6):952-8. PMID: 23648841.
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    54. Paulson AS, Tran Cao HS, Tempero MA, Lowy A. Therapeutic advances in pancreatic cancer. Gastroenterology. 2013 Jun; 144(6):1316-26. PMID: 23622141.
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    55. Garmy-Susini B, Avraamides CJ, Desgrosellier JS, Schmid MC, Foubert P, Ellies LG, Lowy A, Blair SL, Vandenberg SR, Datnow B, Wang HY, Cheresh DA, Varner J. PI3Ka activates integrin a4ß1 to establish a metastatic niche in lymph nodes. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9042-7. PMID: 23671068.
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    56. Katz MH, Marsh R, Herman JM, Shi Q, Collison E, Venook AP, Kindler HL, Alberts SR, Philip P, Lowy A, Pisters PW, Posner MC, Berlin JD, Ahmad SA. Borderline resectable pancreatic cancer: need for standardization and methods for optimal clinical trial design. Ann Surg Oncol. 2013 Aug; 20(8):2787-95. PMID: 23435609.
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    57. Tempero MA, Klimstra D, Berlin J, Hollingsworth T, Kim P, Merchant N, Moore M, Pleskow D, Wang-Gillam A, Lowy A. Changing the way we do business: recommendations to accelerate biomarker development in pancreatic cancer. Clin Cancer Res. 2013 Feb 01; 19(3):538-40. PMID: 23344262.
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    58. Yip-Schneider MT, Wu H, Hruban RH, Lowy A, Crooks PA, Schmidt CM. Efficacy of dimethylaminoparthenolide and sulindac in combination with gemcitabine in a genetically engineered mouse model of pancreatic cancer. Pancreas. 2013 Jan; 42(1):160-7. PMID: 22699205.
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    59. Kelber JA, Reno T, Kaushal S, Metildi C, Wright T, Stoletov K, Weems JM, Park FD, Mose E, Wang Y, Hoffman RM, Lowy A, Bouvet M, Klemke RL. KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer. Cancer Res. 2012 May 15; 72(10):2554-64. PMID: 22589274; PMCID: PMC3366503.
    60. Heinrich EL, Lee W, Lu J, Lowy A, Kim J. Chemokine CXCL12 activates dual CXCR4 and CXCR7-mediated signaling pathways in pancreatic cancer cells. J Transl Med. 2012 Apr 02; 10:68. PMID: 22472349; PMCID: PMC3342892.
    61. Yu PT, Babicky M, Jaquish D, French R, Marayuma K, Mose E, Niessen S, Hoover H, Shields D, Cheresh D, Cravatt BF, Lowy A. The RON-receptor regulates pancreatic cancer cell migration through phosphorylation-dependent breakdown of the hemidesmosome. Int J Cancer. 2012 Oct 15; 131(8):1744-54. PMID: 22275185; PMCID: PMC3424378.
    62. Qiu W, Sahin F, Iacobuzio-Donahue CA, Garcia-Carracedo D, Wang WM, Kuo CY, Chen D, Arking DE, Lowy A, Hruban RH, Remotti HE, Su GH. Disruption of p16 and activation of Kras in pancreas increase ductal adenocarcinoma formation and metastasis in vivo. Oncotarget. 2011 Nov; 2(11):862-73. PMID: 22113502.
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    63. Jaquish DV, Yu PT, Shields DJ, French RP, Maruyama KP, Niessen S, Hoover H, A Cheresh D, Cravatt B, Lowy A. IGF1-R signals through the RON receptor to mediate pancreatic cancer cell migration. Carcinogenesis. 2011 Aug; 32(8):1151-6. PMID: 21565828; PMCID: PMC3149203.
    64. Lee SH, Hao E, Kiselyuk A, Shapiro J, Shields DJ, Lowy A, Levine F, Itkin-Ansari P. The Id3/E47 axis mediates cell-cycle control in human pancreatic ducts and adenocarcinoma. Mol Cancer Res. 2011 Jun; 9(6):782-90. PMID: 21498546; PMCID: PMC3954712.
    65. Tseng WW, Winer D, Kenkel JA, Choi O, Shain AH, Pollack JR, French R, Lowy A, Engleman EG. Development of an orthotopic model of invasive pancreatic cancer in an immunocompetent murine host. Clin Cancer Res. 2010 Jul 15; 16(14):3684-95. PMID: 20534740; PMCID: PMC3085509.
    66. Garmy-Susini B, Avraamides CJ, Schmid MC, Foubert P, Ellies LG, Barnes L, Feral C, Papayannopoulou T, Lowy A, Blair SL, Cheresh D, Ginsberg M, Varner JA. Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis. Cancer Res. 2010 Apr 15; 70(8):3042-51. PMID: 20388801; PMCID: PMC2856096.
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    68. Thomas RM, Jaquish DV, French RP, Lowy A. The RON tyrosine kinase receptor regulates vascular endothelial growth factor production in pancreatic cancer cells. Pancreas. 2010 Apr; 39(3):301-7. PMID: 20358644; PMCID: PMC2849173.
    69. Tran Cao HS, Kellogg B, Lowy A, Bouvet M. Cystic neoplasms of the pancreas. Surg Oncol Clin N Am. 2010 Apr; 19(2):267-95. PMID: 20159515; PMCID: PMC4383087.
    70. McClaine RJ, Lowy A, Sussman JJ, Schmulewitz N, Grisell DL, Ahmad SA. Neoadjuvant therapy may lead to successful surgical resection and improved survival in patients with borderline resectable pancreatic cancer. HPB (Oxford). 2010 Feb; 12(1):73-9. PMID: 20495649; PMCID: PMC2814408.
    71. Logan-Collins J, Thomas RM, Yu P, Jaquish D, Mose E, French R, Stuart W, McClaine R, Aronow B, Hoffman RM, Waltz SE, Lowy A. Silencing of RON receptor signaling promotes apoptosis and gemcitabine sensitivity in pancreatic cancers. Cancer Res. 2010 Feb 01; 70(3):1130-40. PMID: 20103639; PMCID: PMC2943733.
    72. Shen X, Artinyan A, Jackson D, Thomas RM, Lowy A, Kim J. Chemokine receptor CXCR4 enhances proliferation in pancreatic cancer cells through AKT and ERK dependent pathways. Pancreas. 2010 Jan; 39(1):81-7. PMID: 19820417.
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    73. Morton JP, Timpson P, Karim SA, Ridgway RA, Athineos D, Doyle B, Jamieson NB, Oien KA, Lowy A, Brunton VG, Frame MC, Evans TR, Sansom OJ. Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proc Natl Acad Sci U S A. 2010 Jan 05; 107(1):246-51. PMID: 20018721; PMCID: PMC2806749.
    74. McElroy MK, Lowy A, Weidner N. Case report: focal nesidioblastosis ("nesidioblastoma") in an adult. Hum Pathol. 2010 Mar; 41(3):447-51. PMID: 20004945.
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    75. McClaine RJ, Lowy A, Matthews JB, Schmulewitz N, Sussman JJ, Ingraham AM, Ahmad SA. A comparison of pancreaticoduodenectomy and duodenum-preserving head resection for the treatment of chronic pancreatitis. HPB (Oxford). 2009 Dec; 11(8):677-83. PMID: 20495636; PMCID: PMC2799621.
    76. Philip PA, Mooney M, Jaffe D, Eckhardt G, Moore M, Meropol N, Emens L, O'Reilly E, Korc M, Ellis L, Benedetti J, Rothenberg M, Willett C, Tempero M, Lowy A, Abbruzzese J, Simeone D, Hingorani S, Berlin J, Tepper J. Consensus report of the national cancer institute clinical trials planning meeting on pancreas cancer treatment. J Clin Oncol. 2009 Nov 20; 27(33):5660-9. PMID: 19858397.
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    77. Shen X, Mailey B, Ellenhorn JD, Chu PG, Lowy A, Kim J. CC chemokine receptor 9 enhances proliferation in pancreatic intraepithelial neoplasia and pancreatic cancer cells. J Gastrointest Surg. 2009 Nov; 13(11):1955-62; discussion 1962. PMID: 19756884.
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    78. Spence JR, Lange AW, Lin SC, Kaestner KH, Lowy A, Kim I, Whitsett JA, Wells JM. Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell. 2009 Jul; 17(1):62-74. PMID: 19619492; PMCID: PMC2734336.
    79. Abrams RA, Lowy A, O'Reilly EM, Wolff RA, Picozzi VJ, Pisters PW. Combined modality treatment of resectable and borderline resectable pancreas cancer: expert consensus statement. Ann Surg Oncol. 2009 Jul; 16(7):1751-6. PMID: 19390900.
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    80. Dai M, Fong Y, Lowy A. Treatment of T3 gallbladder cancer. J Gastrointest Surg. 2009 Nov; 13(11):2040-2. PMID: 19194769.
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    81. Kooby DA, Gillespie T, Bentrem D, Nakeeb A, Schmidt MC, Merchant NB, Parikh AA, Martin RC, Scoggins CR, Ahmad S, Kim HJ, Park J, Johnston F, Strouch MJ, Menze A, Rymer J, McClaine R, Strasberg SM, Talamonti MS, Staley CA, McMasters KM, Lowy A, Byrd-Sellers J, Wood WC, Hawkins WG. Left-sided pancreatectomy: a multicenter comparison of laparoscopic and open approaches. Ann Surg. 2008 Sep; 248(3):438-46. PMID: 18791364.
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    82. Lowy A. Beyond the ivory tower: outcomes following surgery for ampullary cancer. Ann Surg Oncol. 2008 Jul; 15(7):1813-4. PMID: 18425553; PMCID: PMC2467499.
    83. Qian J, Sarnaik AA, Bonney TM, Keirsey J, Combs KA, Steigerwald K, Acharya S, Behbehani GK, Barton MC, Lowy A, Groden J. The APC tumor suppressor inhibits DNA replication by directly binding to DNA via its carboxyl terminus. Gastroenterology. 2008 Jul; 135(1):152-62. PMID: 18474248; PMCID: PMC2832605.
    84. Lowy A. Neoadjuvant therapy for pancreatic cancer. J Gastrointest Surg. 2008 Sep; 12(9):1600-8. PMID: 18259825.
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    85. Reed VK, Krishnan S, Mansfield PF, Bhosale PR, Kim M, Das P, Janjan NA, Delclos ME, Lowy A, Feig BW, Pisters PW, Ajani JA, Crane CH. Incidence, natural history, and patterns of locoregional recurrence in gastric cancer patients treated with preoperative chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2008 Jul 01; 71(3):741-7. PMID: 18164837; PMCID: PMC4741525.
    86. O'Toole T, Lowy A, Rabkin E, Chauhan S. Large pancreatic serous cystadenoma presenting with biliary obstruction. Gastrointest Endosc. 2007 Dec; 66(6):1229-30; discussion 1230. PMID: 18061724.
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    87. Logan-Collins JM, Lowy A, Robinson-Smith TM, Kumar S, Sussman JJ, James LE, Ahmad SA. VEGF expression predicts survival in patients with peritoneal surface metastases from mucinous adenocarcinoma of the appendix and colon. Ann Surg Oncol. 2008 Mar; 15(3):738-44. PMID: 18043973.
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    88. Mierzwa ML, McCluskey CM, Barrett WL, Lowy A, Sussman J, Sorger J. Interstitial brachytherapy for soft tissue sarcoma: A single institution experience. Brachytherapy. 2007 Oct-Dec; 6(4):298-303. PMID: 17959424.
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    89. Nair RR, Lowy A, McIntyre B, Sussman JJ, Matthews JB, Ahmad SA. Fistulojejunostomy for the management of refractory pancreatic fistula. Surgery. 2007 Oct; 142(4):636-42; discussion 642.e1. PMID: 17950358.
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    90. Thomas RM, Toney K, Fenoglio-Preiser C, Revelo-Penafiel MP, Hingorani SR, Tuveson DA, Waltz SE, Lowy A. The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression. Cancer Res. 2007 Jul 01; 67(13):6075-82. PMID: 17616662.
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    91. Wray CJ, Lowy A, Matthews JB, James LE, Mammen JM, Choe KA, Hanto DW, Ahmad SA. Intraoperative margin re-resection for colorectal liver metastases. J Surg Educ. 2007 May-Jun; 64(3):150-7. PMID: 17574176.
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    92. Wells JM, Esni F, Boivin GP, Aronow BJ, Stuart W, Combs C, Sklenka A, Leach SD, Lowy A. Wnt/beta-catenin signaling is required for development of the exocrine pancreas. BMC Dev Biol. 2007 Jan 12; 7:4. PMID: 17222338; PMCID: PMC1783845.
    93. Sarnaik AA, Sussman JJ, Ahmad SA, McIntyre BC, Lowy A. Technology for the delivery of hyperthermic intraoperative intraperitoneal chemotherapy: a survey of techniques. Recent Results Cancer Res. 2007; 169:75-82. PMID: 17506250.
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    94. Lowy A, Firdaus I, Roychowdhury D, Redmond K, Howington JA, Sussman JJ, Safa M, Ahmad SA, Reed MF, Rose P, James L, Jazieh AR. A phase II study of sequential neoadjuvant gemcitabine and paclitaxel, radiation therapy with cisplatin and 5-fluorouracil and surgery in locally advanced esophageal carcinoma. Am J Clin Oncol. 2006 Dec; 29(6):555-61. PMID: 17148991.
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    95. Nair RL, Tobias J, Stemmerman G, Lowy A. Cerebral edema in a patient following cytoreductive surgery and hyperthermic intraoperative intraperitoneal chemoperfusion. World J Surg Oncol. 2006 Nov 30; 4:85. PMID: 17137499; PMCID: PMC1697813.
    96. Lowy A, Clements WM, Bishop J, Kong L, Bonney T, Sisco K, Aronow B, Fenoglio-Preiser C, Groden J. beta-Catenin/Wnt signaling regulates expression of the membrane type 3 matrix metalloproteinase in gastric cancer. Cancer Res. 2006 May 01; 66(9):4734-41. PMID: 16651426.
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    97. Hershko DD, Robb BW, Lowy A, Ahmad SA, Ramadas GH, Soldano DA, Sussman JJ. Sentinel lymph node biopsy in thin melanoma patients. J Surg Oncol. 2006 Mar 15; 93(4):279-85. PMID: 16496355.
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    98. Ahmed SA, Wray C, Rilo HL, Choe KA, Gelrud A, Howington JA, Lowy A, Matthews JB. Chronic pancreatitis: recent advances and ongoing challenges. Curr Probl Surg. 2006 Mar; 43(3):127-238. PMID: 16530053.
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    99. Lowy A. Putting the chemo in chemoradiation for pancreatic cancer. Ann Surg Oncol. 2006 Feb; 13(2):135-6. PMID: 16411142.
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    100. Goodman MD, McIntyre B, Shaughnessy EA, Lowy A, Ahmad SA. Forequarter amputation for recurrent breast cancer: a case report and review of the literature. J Surg Oncol. 2005 Nov 01; 92(2):134-41. PMID: 16231376.
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    101. Ahmad SA, Lowy A, Wray CJ, D'Alessio D, Choe KA, James LE, Gelrud A, Matthews JB, Rilo HL. Factors associated with insulin and narcotic independence after islet autotransplantation in patients with severe chronic pancreatitis. J Am Coll Surg. 2005 Nov; 201(5):680-7. PMID: 16256909.
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    102. Wray CJ, Ahmad SA, Lowy A, D'Alessio DA, Gelrud A, Choe KA, Soldano DA, Matthews JB, Rodriguez-Rilo HL. Clinical significance of bacterial cultures from 28 autologous islet cell transplant solutions. Pancreatology. 2005; 5(6):562-9. PMID: 16110254.
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    103. Wray CJ, Ahmad SA, Matthews JB, Lowy A. Surgery for pancreatic cancer: recent controversies and current practice. Gastroenterology. 2005 May; 128(6):1626-41. PMID: 15887155.
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    104. Lowy A. Does size matter most? Reassessing clinical staging for pancreatic cancer. Ann Surg Oncol. 2005 Feb; 12(2):100-1. PMID: 15827787.
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    105. Ahmad SA, Lowy A, McIntyre BC, Matthews JB. Pancreaticoduodenectomy. J Gastrointest Surg. 2005 Jan; 9(1):138-43. PMID: 15623455.
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    106. Kim J, Nikiforov YE, Moulton JS, Lowy A. Multiple focal nodular hyperplasia of the liver in a 21-year-old woman. J Gastrointest Surg. 2004 Jul-Aug; 8(5):591-5. PMID: 15239996.
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    107. Ahmad SA, Kim J, Sussman JJ, Soldano DA, Pennington LJ, James LE, Lowy A. Reduced morbidity following cytoreductive surgery and intraperitoneal hyperthermic chemoperfusion. Ann Surg Oncol. 2004 Apr; 11(4):387-92. PMID: 15070598.
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    108. Billingsley KG, Stern LE, Lowy A, Kahlenberg MS, Thomas CR. Uncommon anal neoplasms. Surg Oncol Clin N Am. 2004 Apr; 13(2):375-88. PMID: 15137963.
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    109. Lowy A. From bad to worse: prognostic factors in pancreatic cancer. Ann Surg Oncol. 2004 Feb; 11(2):117-8. PMID: 14761910.
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    110. Kim J, Ahmad SA, Lowy A, Buell JF, Pennington LJ, Moulton JS, Matthews JB, Hanto DW. An algorithm for the accurate identification of benign liver lesions. Am J Surg. 2004 Feb; 187(2):274-9. PMID: 14769319.
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    111. Hingorani SR, Petricoin EF, Maitra A, Rajapakse V, King C, Jacobetz MA, Ross S, Conrads TP, Veenstra TD, Hitt BA, Kawaguchi Y, Johann D, Liotta LA, Crawford HC, Putt ME, Jacks T, Wright CV, Hruban RH, Lowy A, Tuveson DA. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell. 2003 Dec; 4(6):437-50. PMID: 14706336.
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    112. Rodriguez Rilo HL, Ahmad SA, D'Alessio D, Iwanaga Y, Kim J, Choe KA, Moulton JS, Martin J, Pennington LJ, Soldano DA, Biliter J, Martin SP, Ulrich CD, Somogyi L, Welge J, Matthews JB, Lowy A. Total pancreatectomy and autologous islet cell transplantation as a means to treat severe chronic pancreatitis. J Gastrointest Surg. 2003 Dec; 7(8):978-89. PMID: 14675707.
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    113. Kim J, Ahmad SA, Lowy A, Buell JF, Pennington LJ, Soldano DA, James LE, Matthews JB, Hanto DW. Increased biliary fistulas after liver resection with the harmonic scalpel. Am Surg. 2003 Sep; 69(9):815-9. PMID: 14509335.
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    114. Clements WM, Martin SP, Stemmerman G, Lowy A. Ampullary carcinoid tumors: rationale for an aggressive surgical approach. J Gastrointest Surg. 2003 Sep-Oct; 7(6):773-6. PMID: 13129555.
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    115. Clements WM, Lowy A, Groden J. Adenomatous polyposis coli/beta-catenin interaction and downstream targets: altered gene expression in gastrointestinal tumors. Clin Colorectal Cancer. 2003 Aug; 3(2):113-20. PMID: 12952568.
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    116. Sarnaik AA, Sussman JJ, Ahmad SA, Lowy A. Technology of intraperitoneal chemotherapy administration: a survey of techniques with a review of morbidity and mortality. Surg Oncol Clin N Am. 2003 Jul; 12(3):849-63. PMID: 14567036.
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    117. Sarnaik AA, Saad AG, Mutema GK, Martin SP, Attar A, Lowy A. Osteoclast-like giant cell tumor of the pancreas associated with a mucinous cystadenocarcinoma. Surgery. 2003 Jun; 133(6):700-1. PMID: 12796742.
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    118. Lowy A, Fenoglio-Preiser C, Kim OJ, Kordich J, Gomez A, Knight J, James L, Groden J. Dysregulation of beta-catenin expression correlates with tumor differentiation in pancreatic duct adenocarcinoma. Ann Surg Oncol. 2003 Apr; 10(3):284-90. PMID: 12679314.
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    119. Sundararajan V, Robinson-Smith TM, Lowy A. Duodenal gangliocytic paraganglioma with lymph node metastasis: a case report and review of the literature. Arch Pathol Lab Med. 2003 Mar; 127(3):e139-41. PMID: 12653602.
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    120. Gebrail F, Lowy A, Cualing H. Pathologic quiz case: A 43-year-old woman with a subcutaneous mass in the upper arm. Arch Pathol Lab Med. 2003 Jan; 127(1):113-4. PMID: 12562278.
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    121. Lowy A. Transgenic models of pancreatic cancer. Int J Gastrointest Cancer. 2003; 33(1):71-8. PMID: 12909739.
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    122. Lowy A, Knight J, Groden J. Restoration of E-cadherin/beta-catenin expression in pancreatic cancer cells inhibits growth by induction of apoptosis. Surgery. 2002 Aug; 132(2):141-8. PMID: 12219004.
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    123. Clements WM, Wang J, Sarnaik A, Kim OJ, MacDonald J, Fenoglio-Preiser C, Groden J, Lowy A. beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer. Cancer Res. 2002 Jun 15; 62(12):3503-6. PMID: 12067995.
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