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Combinatorial protection of cochlear hair cells: not too little but not too much. Front Cell Neurosci. 2024; 18:1458720.
Kurabi A, Pak K, Lee EJ, Ryan AF. PMID: 39355176; PMCID: PMC11442228.
View in:
PubMed Mentions:
-
Murine nuclear tyrosyl-tRNA synthetase deficiency leads to fat storage deficiency and hearing loss. J Biol Chem. 2024 Sep 12; 300(10):107756.
Jones JA, Zhou J, Dong J, Huitron-Resendiz S, Boussaty E, Chavez E, Wei N, Dumitru CD, Morodomi Y, Kanaji T, Ryan AF, Friedman R, Zhou T, Kanaji S, Wortham M, Schenk S, Roberts AJ, Yang XL. PMID: 39260699; PMCID: PMC11470617.
View in:
PubMed Mentions: Fields:
-
Anti-inflammatory response to 1,8-Cineol and associated microbial communities in Otitis media patients. Sci Rep. 2024 07 16; 14(1):16362.
Leichtle A, Lupatsii M, Graspeuntner S, Jeschke S, Penxová Z, Kurabi A, Ryan AF, Rupp J, Pries R, Bruchhage KL. PMID: 39014066; PMCID: PMC11252366.
View in:
PubMed Mentions: Fields:
Translation:
HumansCells
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Genetic architecture distinguishes tinnitus from hearing loss. Nat Commun. 2024 Jan 19; 15(1):614.
Clifford RE, Maihofer AX, Chatzinakos C, Coleman JRI, Daskalakis NP, Gasperi M, Hogan K, Mikita EA, Stein MB, Tcheandjieu C, Telese F, Zuo Y, Ryan AF, Nievergelt CM. PMID: 38242899; PMCID: PMC10799010.
View in:
PubMed Mentions:
3 Fields:
Translation:
Humans
-
Immunomodulatory Response of the Middle Ear Epithelial Cells in Otitis Media. Otol Neurotol. 2024 Mar 01; 45(3):e248-e255.
Leffers D, Penxova Z, Kempin T, Därr M, Fleckner J, Hollfelder D, Ryan AF, Bruchhage KL, Kurabi A, Leichtle A. PMID: 38238924; PMCID: PMC10922874.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
-
Otitis media: Interactions between host and environment, immune and inflammatory responses. Int J Pediatr Otorhinolaryngol. 2024 Jan; 176:111798.
Nokso-Koivisto J, Ehrlich GD, Enoksson F, Komatsu K, Mason K, Melhus Å, Patel JA, Vijayasekaran S, Ryan A. PMID: 38041988.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
-
Pro-inflammatory markers associated with COVID-19-related persistent olfactory dysfunction. Int Forum Allergy Rhinol. 2024 Apr; 14(4):786-793.
Jang SS, Pak KS, Strom A, Gomez L, Kim K, Doherty TA, DeConde AS, Ryan AF, Yan CH. PMID: 37676246; PMCID: PMC10918027.
View in:
PubMed Mentions: Fields:
Translation:
Humans
-
Ensuring the future of otitis media research: Interest in and feasibility of a mentoring network program within the otitis media research community. Int J Pediatr Otorhinolaryngol. 2023 Sep; 172:111693.
Ziniel SI, Preciado D, Lee R, Kerschner JE, Ryan AF, Santos-Cortez RLP. PMID: 37579520; PMCID: PMC10523683.
View in:
PubMed Mentions: Fields:
Translation:
Humans
-
Noise-induced hearing loss vulnerability in type III intermediate filament peripherin gene knockout mice. Front Neurol. 2022; 13:962227.
Cederholm JME, Parley KE, Perera CJ, von Jonquieres G, Pinyon JL, Julien JP, Ryugo DK, Ryan AF, Housley GD. PMID: 36226085; PMCID: PMC9549866.
View in:
PubMed Mentions:
1
-
The ECRG4 cleavage product augurin binds the endotoxin receptor and influences the innate immune response during otitis media. Front Genet. 2022; 13:932555.
Kurabi A, Hur DG, Pak K, Gibson M, Webster NJG, Baird A, Eliceiri BP, Ryan AF. PMID: 36092940; PMCID: PMC9461705.
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PubMed Mentions:
-
Essential Role of the Innate Immune Adaptor RIP2 in the Response to Otitis Media. Front Genet. 2022; 13:893085.
Kurabi A, Lee J, Pak K, Leichtle A, Ryan AF. PMID: 35903351; PMCID: PMC9315102.
View in:
PubMed Mentions:
2
-
The Interrelationship of Tinnitus and Hearing Loss Secondary to Age, Noise Exposure, and Traumatic Brain Injury. Ear Hear. 2022 Jul-Aug 01; 43(4):1114-1124.
Clifford RE, Ryan AF,
on behalf of VA Million Veteran Program
. PMID: 35612496; PMCID: PMC11193335.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansPHPublic Health
-
Immunomodulation as a Protective Strategy in Chronic Otitis Media. Front Cell Infect Microbiol. 2022; 12:826192.
Leichtle A, Kurabi A, Leffers D, Därr M, Draf CS, Ryan AF, Bruchhage KL. PMID: 35433505; PMCID: PMC9005906.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
-
HB-EGF Plays a Pivotal Role in Mucosal Hyperplasia During Otitis Media Induced by a Viral Analog. Front Cell Infect Microbiol. 2022; 12:823714.
Sakamoto T, Pak K, Chavez E, Ryan AF, Kurabi A. PMID: 35281434; PMCID: PMC8904902.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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A transcytotic transport mechanism across the tympanic membrane. Sci Rep. 2022 01 19; 12(1):984.
Kurabi A, Pak K, Chavez E, Doan J, Ryan AF. PMID: 35046419; PMCID: PMC8770641.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
-
The FUT2 Variant c.461G>A (p.Trp154*) Is Associated With Differentially Expressed Genes and Nasopharyngeal Microbiota Shifts in Patients With Otitis Media. Front Cell Infect Microbiol. 2021; 11:798246.
Elling CL, Scholes MA, Streubel SO, Larson ED, Wine TM, Bootpetch TC, Yoon PJ, Kofonow JM, Gubbels SP, Cass SP, Robertson CE, Jenkins HA, Prager JD, Frank DN, Chan KH, Friedman NR, Ryan AF, Santos-Cortez RLP. PMID: 35096646; PMCID: PMC8798324.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
-
Leukotriene B4 Is a Major Determinant of Leukocyte Recruitment During Otitis Media. Front Cell Infect Microbiol. 2021; 11:768815.
Heo KW, Pak K, Kurabi A, Ryan AF. PMID: 35004347; PMCID: PMC8727869.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
A Screen of Autophagy Compounds Implicates the Proteasome in Mammalian Aminoglycoside-Induced Hair Cell Damage. Front Cell Dev Biol. 2021; 9:762751.
Draf C, Wyrick T, Chavez E, Pak K, Kurabi A, Leichtle A, Dazert S, Ryan AF. PMID: 34765606; PMCID: PMC8576371.
View in:
PubMed Mentions:
5
-
Editorial: Otitis Media Genomics and the Middle Ear Microbiome. Front Genet. 2021; 12:763688.
Santos-Cortez RLP, Ehrlich GD, Ryan AF. PMID: 34712274; PMCID: PMC8546293.
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PubMed Mentions:
-
Immunohistochemical and qPCR Detection of SARS-CoV-2 in the Human Middle Ear Versus the Nasal Cavity: Case Series. Head Neck Pathol. 2022 Jun; 16(2):607-611.
Kurabi A, Pak K, DeConde AS, Ryan AF, Yan CH. PMID: 34455569; PMCID: PMC8401349.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansCells
-
The role of CDHR3 in susceptibility to otitis media. J Mol Med (Berl). 2021 11; 99(11):1571-1583.
Hirsch SD, Elling CL, Bootpetch TC, Scholes MA, Hafrén L, Streubel SO, Pine HS, Wine TM, Szeremeta W, Prager JD, Einarsdottir E, Yousaf A, Baschal EE, Rehman S, Bamshad MJ, Nickerson DA, Riazuddin S, Leal SM, Ahmed ZM, Yoon PJ, Kere J, Chan KH, Mattila PS, Friedman NR, Chonmaitree T, Frank DN, Ryan AF, Santos-Cortez RLP. PMID: 34322716; PMCID: PMC8541908.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
-
[Immunomodulation in Cholesteatoma]. Laryngorhinootologie. 2022 Apr; 101(4):310-319.
Leichtle A, Leffers D, Daerr MG, Draf C, Kurabi A, Ryan AF, Rupp J, Bruchhage KL. PMID: 34233375.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
-
Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease. BMC Med Genomics. 2021 05 24; 14(1):138.
Bickler SW, Cauvi DM, Fisch KM, Prieto JM, Sykes AG, Thangarajah H, Lazar DA, Ignacio RC, Gerstmann DR, Ryan AF, Bickler PE, De Maio A. PMID: 34030677; PMCID: PMC8142073.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells
-
Macrophage Depletion in CCR2-/- Mice Delays Bacterial Clearance and Enhances Neutrophil Infiltration in an Acute Otitis Media Model. J Infect Dis. 2021 02 03; 223(2):333-341.
Hur DG, Kurabi A, Lim HW, Spriggs M, Pak K, Ryan AF. PMID: 32572481; PMCID: PMC7857354.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
-
Molecular Screening Strategy to Identify a Non-invasive Delivery Mechanism for the Treatment of Middle Ear Disorders. Front Med (Lausanne). 2020; 7:503819.
Kurabi A, Cooper M, Spriggs M, Xu Y, Schaerer D, Ryan AF. PMID: 33392211; PMCID: PMC7775502.
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PubMed Mentions:
-
Noise Exposures Causing Hearing Loss Generate Proteotoxic Stress and Activate the Proteostasis Network. Cell Rep. 2020 11 24; 33(8):108431.
Jongkamonwiwat N, Ramirez MA, Edassery S, Wong ACY, Yu J, Abbott T, Pak K, Ryan AF, Savas JN. PMID: 33238128; PMCID: PMC7722268.
View in:
PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
-
Novel Risk Loci in Tinnitus and Causal Inference With Neuropsychiatric Disorders Among Adults of European Ancestry. JAMA Otolaryngol Head Neck Surg. 2020 11 01; 146(11):1015-1025.
Clifford RE, Maihofer AX, Stein MB, Ryan AF, Nievergelt CM. PMID: 32970095; PMCID: PMC7516809.
View in:
PubMed Mentions:
28 Fields:
Translation:
Humans
-
Multi-omic studies on missense PLG variants in families with otitis media. Sci Rep. 2020 09 14; 10(1):15035.
Bootpetch TC, Hafrén L, Elling CL, Baschal EE, Manichaikul AW, Pine HS, Szeremeta W, Scholes MA, Cass SP, Larson ED, Chan KH, Ishaq R, Prager JD, Shaikh RS, Gubbels SP, Yousaf A, University of Washington Center for Mendelian Genomics (UW-CMG), Wine TM, Bamshad MJ, Yoon PJ, Jenkins HA, Nickerson DA, Streubel SO, Friedman NR, Frank DN, Einarsdottir E, Kere J, Riazuddin S, Daly KA, Leal SM, Ryan AF, Mattila PS, Ahmed ZM, Sale MM, Chonmaitree T, Santos-Cortez RLP. PMID: 32929111; PMCID: PMC7490366.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
-
A kinase inhibitor screen identifies signaling pathways regulating mucosal growth during otitis media. PLoS One. 2020; 15(8):e0235634.
Noel J, Suzukawa K, Chavez E, Pak K, Wasserman SI, Kurabi A, Ryan AF. PMID: 32760078; PMCID: PMC7410257.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
-
Otitis media susceptibility and shifts in the head and neck microbiome due to SPINK5 variants. J Med Genet. 2021 07; 58(7):442-452.
Frank DN, Giese APJ, Hafren L, Bootpetch TC, Yarza TKL, Steritz MJ, Pedro M, Labra PJ, Daly KA, Tantoco MLC, Szeremeta W, Reyes-Quintos MRT, Ahankoob N, Llanes EGDV, Pine HS, Yousaf S, Ir D, Einarsdottir E, de la Cruz RAR, Lee NR, Nonato RMA, Robertson CE, Ong KMC, Magno JPM, Chiong ANE, Espiritu-Chiong MC, San Agustin ML, Cruz TLG, Abes GT, Bamshad MJ, Cutiongco-de la Paz EM, Kere J, Nickerson DA, Mohlke KL, Riazuddin S, Chan A, Mattila PS, Leal SM, Ryan AF, Ahmed ZM, Chonmaitree T, Sale MM, Chiong CM, Santos-Cortez RLP. PMID: 32709676; PMCID: PMC8218788.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
-
Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection. Front Genet. 2020; 11:358.
Ryan AF, Nasamran CA, Pak K, Draf C, Fisch KM, Webster N, Kurabi A. PMID: 32351546; PMCID: PMC7174727.
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PubMed Mentions:
16
-
Panel 1: Biotechnology, biomedical engineering and new models of otitis media. Int J Pediatr Otorhinolaryngol. 2020 Mar; 130 Suppl 1:109833.
Gisselsson-Solén M, Tähtinen PA, Ryan AF, Mulay A, Kariya S, Schilder AGM, Valdez TA, Brown S, Nolan RM, Hermansson A, van Ingen G, Marom T. PMID: 31901291; PMCID: PMC7176743.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
-
Panel 3: Genomics, precision medicine and targeted therapies. Int J Pediatr Otorhinolaryngol. 2020 Mar; 130 Suppl 1:109835.
Santos-Cortez RLP, Bhutta MF, Earl JP, Hafrén L, Jennings M, Mell JC, Pichichero ME, Ryan AF, Tateossian H, Ehrlich GD. PMID: 32007292; PMCID: PMC7155947.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
-
Role of the PI3K/AKT pathway and PTEN in otitis media. Exp Cell Res. 2020 02 01; 387(1):111758.
Lee HH, Chin A, Pak K, Wasserman SI, Kurabi A, Ryan AF. PMID: 31837294; PMCID: PMC7824983.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Inflammation associated with noise-induced hearing loss. J Acoust Soc Am. 2019 11; 146(5):4020.
Frye MD, Ryan AF, Kurabi A. PMID: 31795714; PMCID: PMC7480080.
View in:
PubMed Mentions:
54 Fields:
Translation:
HumansAnimalsCells
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Onset kinetics of noise-induced purinergic adaptation of the 'cochlear amplifier'. Purinergic Signal. 2019 09; 15(3):343-355.
Cederholm JME, Ryan AF, Housley GD. PMID: 31377959; PMCID: PMC6737159.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCellsPHPublic Health
-
Lack of the hyaluronan receptor CD44 affects the course of bacterial otitis media and reduces leukocyte recruitment to the middle ear. BMC Immunol. 2019 06 21; 20(1):20.
Lim HW, Pak K, Kurabi A, Ryan AF. PMID: 31226944; PMCID: PMC6588864.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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FUT2 Variants Confer Susceptibility to Familial Otitis Media. Am J Hum Genet. 2018 11 01; 103(5):679-690.
Santos-Cortez RLP, Chiong CM, Frank DN, Ryan AF, Giese APJ, Bootpetch Roberts T, Daly KA, Steritz MJ, Szeremeta W, Pedro M, Pine H, Yarza TKL, Scholes MA, Llanes EGDV, Yousaf S, Friedman N, Tantoco MLC, Wine TM, Labra PJ, Benoit J, Ruiz AG, de la Cruz RAR, Greenlee C, Yousaf A, Cardwell J, Nonato RMA, Ray D, Ong KMC, So E, Robertson CE, Dinwiddie J, Lagrana-Villagracia SM, University of Washington Center for Mendelian Genomics (UWCMG), Gubbels SP, Shaikh RS, Cass SP, Einarsdottir E, Lee NR, Schwartz DA, Gloria-Cruz TLI, Bamshad MJ, Yang IV, Kere J, Abes GT, Prager JD, Riazuddin S, Chan AL, Yoon PJ, Nickerson DA, Cutiongco-de la Paz EM, Streubel SO, Reyes-Quintos MRT, Jenkins HA, Mattila P, Chan KH, Mohlke KL, Leal SM, Hafrén L, Chonmaitree T, Sale MM, Ahmed ZM. PMID: 30401457; PMCID: PMC6217759.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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Active Transport of Peptides Across the Intact Human Tympanic Membrane. Sci Rep. 2018 08 07; 8(1):11815.
Kurabi A, Schaerer D, Noack V, Bernhardt M, Pak K, Alexander T, Husseman J, Nguyen Q, Harris JP, Ryan AF. PMID: 30087425; PMCID: PMC6081404.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimals
-
Screening Mammalian Cochlear Hair Cells to Identify Critical Processes in Aminoglycoside-Mediated Damage. Front Cell Neurosci. 2018; 12:179.
Lim HW, Pak K, Ryan AF, Kurabi A. PMID: 30013464; PMCID: PMC6036173.
View in:
PubMed Mentions:
6
-
Screening antioxidants for the protection of cochlear sensory cells. Neural Regen Res. 2018 Jan; 13(1):62-64.
Hur DG, Kurabi A, Ryan AF. PMID: 29451206; PMCID: PMC5840991.
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PubMed Mentions:
5
-
A kinase inhibitor library screen identifies novel enzymes involved in ototoxic damage to the murine organ of Corti. PLoS One. 2017; 12(10):e0186001.
Ryals M, Pak K, Jalota R, Kurabi A, Ryan AF. PMID: 29049311; PMCID: PMC5648133.
View in:
PubMed Mentions:
6 Fields:
Translation:
Animals
-
Otitis Media and Nasopharyngeal Colonization in ccl3-/- Mice. Infect Immun. 2017 11; 85(11).
Deniffel D, Nuyen B, Pak K, Suzukawa K, Hung J, Kurabi A, Wasserman SI, Ryan AF. PMID: 28847849; PMCID: PMC5649018.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
-
An Antioxidant Screen Identifies Candidates for Protection of Cochlear Hair Cells from Gentamicin Toxicity. Front Cell Neurosci. 2017; 11:242.
Noack V, Pak K, Jalota R, Kurabi A, Ryan AF. PMID: 28867994; PMCID: PMC5563352.
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PubMed Mentions:
23
-
Optimisation of peptides that actively cross the tympanic membrane by random amino acid extension: a phage display study. J Drug Target. 2018 02; 26(2):127-134.
Kurabi A, Schaerer D, Chang L, Pak K, Ryan AF. PMID: 28658990; PMCID: PMC6223256.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
Panel 5: Immunology. Otolaryngol Head Neck Surg. 2017 04; 156(4_suppl):S63-S75.
Kyd JM, Hotomi M, Kono M, Kurabi A, Pichichero M, Ryan A, Swords WE, Thornton R. PMID: 28372530.
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PubMed Mentions:
2 Fields:
Translation:
Humans
-
Peptides actively transported across the tympanic membrane: Functional and structural properties. PLoS One. 2017; 12(2):e0172158.
Kurabi A, Beasley KA, Chang L, McCann J, Pak K, Ryan AF. PMID: 28234923; PMCID: PMC5325213.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
-
Global Analysis of Protein Expression of Inner Ear Hair Cells. J Neurosci. 2017 02 01; 37(5):1320-1339.
Hickox AE, Wong AC, Pak K, Strojny C, Ramirez M, Yates JR, Ryan AF, Savas JN. PMID: 28039372; PMCID: PMC5296798.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Cellular mechanisms of noise-induced hearing loss. Hear Res. 2017 06; 349:129-137.
Kurabi A, Keithley EM, Housley GD, Ryan AF, Wong AC. PMID: 27916698; PMCID: PMC6750278.
-
Both canonical and non-canonical NF-κB activation contribute to the proliferative response of the middle ear mucosa during bacterial infection. Innate Immun. 2016 11; 22(8):626-634.
Cho CG, Pak K, Webster N, Kurabi A, Ryan AF. PMID: 27655045; PMCID: PMC5333768.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
-
The Promoter and Multiple Enhancers of the pou4f3 Gene Regulate Expression in Inner Ear Hair Cells. Mol Neurobiol. 2017 09; 54(7):5414-5426.
Masuda M, Li Y, Pak K, Chavez E, Mullen L, Ryan AF. PMID: 27592349; PMCID: PMC5336531.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
-
Temporary and Permanent Noise-induced Threshold Shifts: A Review of Basic and Clinical Observations. Otol Neurotol. 2016 09; 37(8):e271-5.
Ryan AF, Kujawa SG, Hammill T, Le Prell C, Kil J. PMID: 27518135; PMCID: PMC4988324.
View in:
PubMed Mentions:
64 Fields:
Translation:
HumansAnimalsPHPublic Health
-
Impulse Noise Injury Model. Mil Med. 2016 05; 181(5 Suppl):59-69.
Chan P, Ho K, Ryan AF. PMID: 27168554.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimals
-
Discovery of a Biological Mechanism of Active Transport through the Tympanic Membrane to the Middle Ear. Sci Rep. 2016 Mar 07; 6:22663.
Kurabi A, Pak KK, Bernhardt M, Baird A, Ryan AF. PMID: 26946957; PMCID: PMC4780071.
View in:
PubMed Mentions:
14 Fields:
Translation:
Animals
-
Innate Immunity: Orchestrating Inflammation and Resolution of Otitis Media. Curr Allergy Asthma Rep. 2016 Jan; 16(1):6.
Kurabi A, Pak K, Ryan AF, Wasserman SI. PMID: 26732809; PMCID: PMC6752202.
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PubMed Mentions:
21 Fields:
Translation:
Humans
-
Tinnitus: Research supported by the Tinnitus Research Consortium. Hear Res. 2016 04; 334:1.
Ryan AF, Dobie RA, Dubno JR, Lonsbury-Martin BL. PMID: 26739791; PMCID: PMC6743484.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
-
The Sustained-Exposure Dexamethasone Formulation OTO-104 Offers Effective Protection against Noise-Induced Hearing Loss. Audiol Neurootol. 2016; 21(1):12-21.
Harrop-Jones A, Wang X, Fernandez R, Dellamary L, Ryan AF, LeBel C, Piu F. PMID: 26655654.
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PubMed Mentions:
17 Fields:
Translation:
Animals
-
Properties of ATP-gated ion channels assembled from P2X2 subunits in mouse cochlear Reissner's membrane epithelial cells. Purinergic Signal. 2015 Dec; 11(4):551-60.
Morton-Jones RT, Vlajkovic SM, Thorne PR, Cockayne DA, Ryan AF, Housley GD. PMID: 26424615; PMCID: PMC4648790.
View in:
PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
-
Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier. Nat Commun. 2015 May 12; 6:7115.
Froud KE, Wong AC, Cederholm JM, Klugmann M, Sandow SL, Julien JP, Ryan AF, Housley GD. PMID: 25965946; PMCID: PMC4432632.
View in:
PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
-
Mechanisms of sensorineural cell damage, death and survival in the cochlea. Front Aging Neurosci. 2015; 7:58.
Wong AC, Ryan AF. PMID: 25954196; PMCID: PMC4404918.
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PubMed Mentions:
129
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The transcriptome of a complete episode of acute otitis media. BMC Genomics. 2015 Apr 03; 16:259.
Hernandez M, Leichtle A, Pak K, Webster NJ, Wasserman SI, Ryan AF. PMID: 25888408; PMCID: PMC4394589.
View in:
PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
-
NOD-Like Receptor Signaling in Cholesteatoma. Biomed Res Int. 2015; 2015:408169.
Leichtle A, Klenke C, Ebmeyer J, Daerr M, Bruchhage KL, Hoffmann AS, Ryan AF, Wollenberg B, Sudhoff H. PMID: 25922834; PMCID: PMC4398947.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells
-
Transcription factors with conserved binding sites near ATOH1 on the POU4F3 gene enhance the induction of cochlear hair cells. Mol Neurobiol. 2015 Apr; 51(2):672-84.
Ikeda R, Pak K, Chavez E, Ryan AF. PMID: 25015561; PMCID: PMC4291311.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
-
All Akt isoforms (Akt1, Akt2, Akt3) are involved in normal hearing, but only Akt2 and Akt3 are involved in auditory hair cell survival in the mammalian inner ear. PLoS One. 2015; 10(3):e0121599.
Brand Y, Levano S, Radojevic V, Naldi AM, Setz C, Ryan AF, Pak K, Hemmings BA, Bodmer D. PMID: 25811375; PMCID: PMC4374771.
View in:
PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
-
The regulation of gene expression in hair cells. Hear Res. 2015 Nov; 329:33-40.
Ryan AF, Ikeda R, Masuda M. PMID: 25616095; PMCID: PMC4510037.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Skeletal muscle intermediate filaments form a stress-transmitting and stress-signaling network. J Cell Sci. 2015 Jan 15; 128(2):219-24.
Palmisano MG, Bremner SN, Hornberger TA, Meyer GA, Domenighetti AA, Shah SB, Kiss B, Kellermayer M, Ryan AF, Lieber RL. PMID: 25413344; PMCID: PMC4294770.
View in:
PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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Neural cell adhesion molecule NrCAM is expressed in the mammalian inner ear and modulates spiral ganglion neurite outgrowth in an in vitro alternate choice assay. J Mol Neurosci. 2015 Apr; 55(4):836-44.
Brand Y, Sung M, Pak K, Chavez E, Wei E, Radojevic V, Bodmer D, Ryan AF. PMID: 25407819; PMCID: PMC4355056.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
-
C-Jun N-terminal kinase (JNK) isoforms play differing roles in otitis media. BMC Immunol. 2014 Oct 14; 15:46.
Yao W, Frie M, Pan J, Pak K, Webster N, Wasserman SI, Ryan AF. PMID: 25311344; PMCID: PMC4200133.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
-
A mouse model of otitis media identifies HB-EGF as a mediator of inflammation-induced mucosal proliferation. PLoS One. 2014; 9(7):e102739.
Suzukawa K, Tomlin J, Pak K, Chavez E, Kurabi A, Baird A, Wasserman SI, Ryan AF. PMID: 25033458; PMCID: PMC4102546.
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PubMed Mentions:
13 Fields:
Translation:
Animals
-
Inhibition of MMP-2 but not MMP-9 influences inner ear spiral ganglion neurons in vitro. Cell Mol Neurobiol. 2014 Oct; 34(7):1011-21.
Sung M, Wei E, Chavez E, Jain N, Levano S, Binkert L, Ramseier A, Setz C, Bodmer D, Ryan AF, Brand Y. PMID: 24935409; PMCID: PMC4386629.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
The inflammasome adaptor ASC contributes to multiple innate immune processes in the resolution of otitis media. Innate Immun. 2015 Feb; 21(2):203-14.
Kurabi A, Lee J, Wong C, Pak K, Hoffman HM, Ryan AF, Wasserman SI. PMID: 24652041; PMCID: PMC4379507.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
-
Neural cell adhesion molecule L1 modulates type I but not type II inner ear spiral ganglion neurite outgrowth in an in vitro alternate choice assay. J Mol Neurosci. 2013 Nov; 51(3):663-70.
Brand Y, Sung M, Chavez E, Wei E, Pak KK, Housley GD, Bodmer D, Ryan AF. PMID: 23760987; PMCID: PMC3825176.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
-
Ecrg4 attenuates the inflammatory proliferative response of mucosal epithelial cells to infection. PLoS One. 2013; 8(4):e61394.
Kurabi A, Pak K, Dang X, Coimbra R, Eliceiri BP, Ryan AF, Baird A. PMID: 23626679; PMCID: PMC3634077.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
-
ATP-gated ion channels mediate adaptation to elevated sound levels. Proc Natl Acad Sci U S A. 2013 Apr 30; 110(18):7494-9.
Housley GD, Morton-Jones R, Vlajkovic SM, Telang RS, Paramananthasivam V, Tadros SF, Wong AC, Froud KE, Cederholm JM, Sivakumaran Y, Snguanwongchai P, Khakh BS, Cockayne DA, Thorne PR, Ryan AF. PMID: 23592720; PMCID: PMC3645545.
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PubMed Mentions:
52 Fields:
Translation:
AnimalsCellsPHPublic Health
-
Panel 4: Recent advances in otitis media in molecular biology, biochemistry, genetics, and animal models. Otolaryngol Head Neck Surg. 2013 Apr; 148(4 Suppl):E52-63.
Li JD, Hermansson A, Ryan AF, Bakaletz LO, Brown SD, Cheeseman MT, Juhn SK, Jung TT, Lim DJ, Lim JH, Lin J, Moon SK, Post JC. PMID: 23536532; PMCID: PMC4006668.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimals
-
Changes in responsiveness of rat spiral ganglion neurons to neurotrophins across age: differential regulation of survival and neuritogenesis. Int J Neurosci. 2013 Jul; 123(7):465-75.
Kondo K, Pak K, Chavez E, Mullen L, Euteneuer S, Ryan AF. PMID: 23301942; PMCID: PMC3897193.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
-
Mutation of the ATP-gated P2X(2) receptor leads to progressive hearing loss and increased susceptibility to noise. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2228-33.
Yan D, Zhu Y, Walsh T, Xie D, Yuan H, Sirmaci A, Fujikawa T, Wong AC, Loh TL, Du L, Grati M, Vlajkovic SM, Blanton S, Ryan AF, Chen ZY, Thorne PR, Kachar B, Tekin M, Zhao HB, Housley GD, King MC, Liu XZ. PMID: 23345450; PMCID: PMC3568371.
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PubMed Mentions:
69 Fields:
Translation:
HumansAnimalsCells
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Neurotrophins differentially stimulate the growth of cochlear neurites on collagen surfaces and in gels. Neural Regen Res. 2013; 8(17):1541-1550.
Xie J, Pak K, Evans A, Kamgar-Parsi A, Fausti S, Mullen L, Ryan AF. PMID: 24459465; PMCID: PMC3897172.
View in:
PubMed Mentions:
5
-
Glial cell line-derived neurotrophic factor (GDNF) induces neuritogenesis in the cochlear spiral ganglion via neural cell adhesion molecule (NCAM). Mol Cell Neurosci. 2013 May; 54:30-43.
Euteneuer S, Yang KH, Chavez E, Leichtle A, Loers G, Olshansky A, Pak K, Schachner M, Ryan AF. PMID: 23262364; PMCID: PMC3857543.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
-
Developmental changes in the responsiveness of rat spiral ganglion neurons to neurotrophic factors in dissociated culture: differential responses for survival, neuritogenesis and neuronal morphology. Cell Tissue Res. 2013 Jan; 351(1):15-27.
Jin Y, Kondo K, Ushio M, Kaga K, Ryan AF, Yamasoba T. PMID: 23149719; PMCID: PMC3577061.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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TFE2 and GATA3 enhance induction of POU4F3 and myosin VIIa positive cells in nonsensory cochlear epithelium by ATOH1. Dev Biol. 2012 Dec 01; 372(1):68-80.
Masuda M, Pak K, Chavez E, Ryan AF. PMID: 22985730; PMCID: PMC3483650.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
-
Differential actions of isoflurane and ketamine-based anaesthetics on cochlear function in the mouse. Hear Res. 2012 Oct; 292(1-2):71-9.
Cederholm JM, Froud KE, Wong AC, Ko M, Ryan AF, Housley GD. PMID: 22960466; PMCID: PMC3582347.
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PubMed Mentions:
29 Fields:
Translation:
Animals
-
Systemic immunity influences hearing preservation in cochlear implantation. Otol Neurotol. 2012 Jun; 33(4):532-8.
Souter M, Eastwood H, Marovic P, Kel G, Wongprasartsuk S, Ryan AF, O'Leary SJ. PMID: 22470051; PMCID: PMC3897157.
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PubMed Mentions:
6 Fields:
Translation:
Animals
-
The role of vascular endothelial growth factors and fibroblast growth factors in angiogenesis during otitis media. Audiol Neurootol. 2012; 17(3):148-54.
Husseman J, Palacios SD, Rivkin AZ, Oehl H, Ryan AF. PMID: 22104377; PMCID: PMC3238030.
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PubMed Mentions:
8 Fields:
Translation:
Animals
-
Simvastatin protects auditory hair cells from gentamicin-induced toxicity and activates Akt signaling in vitro. BMC Neurosci. 2011 Nov 14; 12:114.
Brand Y, Setz C, Levano S, Listyo A, Chavez E, Pak K, Sung M, Radojevic V, Ryan AF, Bodmer D. PMID: 22082490; PMCID: PMC3250952.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
-
Ras/p38 and PI3K/Akt but not Mek/Erk signaling mediate BDNF-induced neurite formation on neonatal cochlear spiral ganglion explants. Brain Res. 2012 Jan 09; 1430:25-34.
Mullen LM, Pak KK, Chavez E, Kondo K, Brand Y, Ryan AF. PMID: 22119396; PMCID: PMC3242932.
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PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
-
Type I vs type II spiral ganglion neurons exhibit differential survival and neuritogenesis during cochlear development. Neural Dev. 2011 Oct 11; 6:33.
Barclay M, Ryan AF, Housley GD. PMID: 21989106; PMCID: PMC3207869.
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PubMed Mentions:
58 Fields:
Translation:
AnimalsCells
-
ErbB expression, activation, and inhibition with lapatinib and tyrphostin (AG825) in human vestibular schwannomas. Otol Neurotol. 2011 Jul; 32(5):841-7.
Ahmad ZK, Brown CM, Cueva RA, Ryan AF, Doherty JK. PMID: 21659924; PMCID: PMC3584631.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
-
Innate signaling in otitis media: pathogenesis and recovery. Curr Allergy Asthma Rep. 2011 Feb; 11(1):78-84.
Leichtle A, Lai Y, Wollenberg B, Wasserman SI, Ryan AF. PMID: 21049294; PMCID: PMC3020300.
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PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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TNFA deletion alters apoptosis as well as caspase 3 and 4 expression during otitis media. BMC Immunol. 2011 Jan 26; 12:12.
Ebmeyer J, Leichtle A, Hernandez M, Ebmeyer U, Husseman J, Pak K, Sudhoff H, Broide D, Wasserman SI, Ryan AF. PMID: 21269505; PMCID: PMC3040143.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimals
-
The role of DNA sensing and innate immune receptor TLR9 in otitis media. Innate Immun. 2012 Feb; 18(1):3-13.
Leichtle A, Hernandez M, Lee J, Pak K, Webster NJ, Wollenberg B, Wasserman SI, Ryan AF. PMID: 21239460; PMCID: PMC4041324.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
-
Estrogen receptor expression in sporadic vestibular schwannomas. Otol Neurotol. 2011 Jan; 32(1):158-62.
Brown CM, Ahmad ZK, Ryan AF, Doherty JK. PMID: 21099731; PMCID: PMC3073320.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
-
Activation of TLR2 by a small molecule produced by Staphylococcus epidermidis increases antimicrobial defense against bacterial skin infections. J Invest Dermatol. 2010 Sep; 130(9):2211-21.
Lai Y, Cogen AL, Radek KA, Park HJ, Macleod DT, Leichtle A, Ryan AF, Di Nardo A, Gallo RL. PMID: 20463690; PMCID: PMC2922455.
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PubMed Mentions:
177 Fields:
Translation:
HumansAnimalsCells
-
Merlin knockdown in human Schwann cells: clues to vestibular schwannoma tumorigenesis. Otol Neurotol. 2010 Apr; 31(3):460-6.
Ahmad Z, Brown CM, Patel AK, Ryan AF, Ongkeko R, Doherty JK. PMID: 20195187; PMCID: PMC2873969.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
-
CC chemokine ligand 3 overcomes the bacteriocidal and phagocytic defect of macrophages and hastens recovery from experimental otitis media in TNF-/- mice. J Immunol. 2010 Mar 15; 184(6):3087-97.
Leichtle A, Hernandez M, Ebmeyer J, Yamasaki K, Lai Y, Radek K, Choung YH, Euteneuer S, Pak K, Gallo R, Wasserman SI, Ryan AF. PMID: 20164426; PMCID: PMC2929161.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
-
Type III intermediate filament peripherin inhibits neuritogenesis in type II spiral ganglion neurons in vitro. Neurosci Lett. 2010 Jul 05; 478(2):51-5.
Barclay M, Julien JP, Ryan AF, Housley GD. PMID: 20132868; PMCID: PMC2902986.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
-
Reconstitution of the mast cell population in W/Wv mice. Otol Neurotol. 2010 Jan; 31(1):42-7.
Ebmeyer J, Ebmeyer U, Pak K, Sudhoff H, Broide D, Ryan AF, Wasserman S. PMID: 19752767; PMCID: PMC2796298.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury. Nat Med. 2009 Dec; 15(12):1377-82.
Lai Y, Di Nardo A, Nakatsuji T, Leichtle A, Yang Y, Cogen AL, Wu ZR, Hooper LV, Schmidt RR, von Aulock S, Radek KA, Huang CM, Ryan AF, Gallo RL. PMID: 19966777; PMCID: PMC2880863.
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PubMed Mentions:
329 Fields:
Translation:
Humans
-
The toll-Like receptor adaptor TRIF contributes to otitis media pathogenesis and recovery. BMC Immunol. 2009 Aug 05; 10:45.
Leichtle A, Hernandez M, Pak K, Webster NJ, Wasserman SI, Ryan AF. PMID: 19656404; PMCID: PMC2736931.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
-
TLR4-mediated induction of TLR2 signaling is critical in the pathogenesis and resolution of otitis media. Innate Immun. 2009 Aug; 15(4):205-15.
Leichtle A, Hernandez M, Pak K, Yamasaki K, Cheng CF, Webster NJ, Ryan AF, Wasserman SI. PMID: 19586996; PMCID: PMC3565845.
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PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
-
Cellular targeting for cochlear gene therapy. Adv Otorhinolaryngol. 2009; 66:99-115.
Ryan AF, Mullen LM, Doherty JK. PMID: 19494575; PMCID: PMC4379510.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
-
Gene therapy for the inner ear: challenges and promises. Adv Otorhinolaryngol. 2009; 66:1-12.
Ryan AF, Dazert S. PMID: 19494569; PMCID: PMC4332585.
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PubMed Mentions:
1 Fields:
Translation:
Humans
-
Myeloid differentiation primary response gene 88 is required for the resolution of otitis media. J Infect Dis. 2008 Dec 15; 198(12):1862-9.
Hernandez M, Leichtle A, Pak K, Ebmeyer J, Euteneuer S, Obonyo M, Guiney DG, Webster NJ, Broide DH, Ryan AF, Wasserman SI. PMID: 18986247; PMCID: PMC3584630.
View in:
PubMed Mentions:
46 Fields:
Translation:
AnimalsCells
-
A catechol-O-methyltransferase that is essential for auditory function in mice and humans. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14609-14.
Du X, Schwander M, Moresco EM, Viviani P, Haller C, Hildebrand MS, Pak K, Tarantino L, Roberts A, Richardson H, Koob G, Najmabadi H, Ryan AF, Smith RJ, Müller U, Beutler B. PMID: 18794526; PMCID: PMC2567147.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
-
Vestibular schwannoma quantitative polymerase chain reaction expression of estrogen and progesterone receptors. Laryngoscope. 2008 Aug; 118(8):1458-63.
Patel AK, Alexander TH, Andalibi A, Ryan AF, Doherty JK. PMID: 18670322; PMCID: PMC3570025.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
-
Spiral ganglion outgrowth and hearing development in p75-deficient mice. Audiol Neurootol. 2008; 13(6):388-95.
Brors D, Hansen S, Mlynski R, Volkenstein S, Aletsee C, Sendtner M, Ryan AF, Dazert S. PMID: 18663291.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
-
ErbB and Nrg: potential molecular targets for vestibular schwannoma pharmacotherapy. Otol Neurotol. 2008 Jan; 29(1):50-7.
Doherty JK, Ongkeko W, Crawley B, Andalibi A, Ryan AF. PMID: 18199957.
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PubMed Mentions:
31 Fields:
Translation:
HumansCells
-
Laminin and fibronectin modulate inner ear spiral ganglion neurite outgrowth in an in vitro alternate choice assay. Dev Neurobiol. 2007 Nov; 67(13):1721-30.
Evans AR, Euteneuer S, Chavez E, Mullen LM, Hui EE, Bhatia SN, Ryan AF. PMID: 17600813.
View in:
PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
-
Neuronal expression of peripherin, a type III intermediate filament protein, in the mouse hindbrain. Histochem Cell Biol. 2007 Dec; 128(6):541-50.
Barclay M, Noakes PG, Ryan AF, Julien JP, Housley GD. PMID: 17899157.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
-
Hearing development and spiral ganglion neurite growth in VASP deficient mice. Brain Res. 2007 Oct 31; 1178:73-82.
Dazert S, Schick B, Hartensuer R, Volkenstein S, Aletsee C, Hansen S, Shehata-Dieler WE, Eigenthaler M, Walter U, Ryan AF, Brors D. PMID: 17920567.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
-
N-glycolylneuraminic acid deficiency in mice: implications for human biology and evolution. Mol Cell Biol. 2007 Jun; 27(12):4340-6.
Hedlund M, Tangvoranuntakul P, Takematsu H, Long JM, Housley GD, Kozutsumi Y, Suzuki A, Wynshaw-Boris A, Ryan AF, Gallo RL, Varki N, Varki A. PMID: 17420276; PMCID: PMC1900035.
View in:
PubMed Mentions:
115 Fields:
Translation:
HumansAnimalsCells
-
A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. J Neurosci. 2007 Feb 28; 27(9):2163-75.
Schwander M, Sczaniecka A, Grillet N, Bailey JS, Avenarius M, Najmabadi H, Steffy BM, Federe GC, Lagler EA, Banan R, Hice R, Grabowski-Boase L, Keithley EM, Ryan AF, Housley GD, Wiltshire T, Smith RJ, Tarantino LM, Müller U. PMID: 17329413; PMCID: PMC6673480.
View in:
PubMed Mentions:
101 Fields:
Translation:
HumansAnimalsCells
-
P2X receptor signaling inhibits BDNF-mediated spiral ganglion neuron development in the neonatal rat cochlea. Development. 2007 Apr; 134(7):1407-17.
Greenwood D, Jagger DJ, Huang LC, Hoya N, Thorne PR, Wildman SS, King BF, Pak K, Ryan AF, Housley GD. PMID: 17329369.
View in:
PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
-
Jun N-terminal protein kinase enhances middle ear mucosal proliferation during bacterial otitis media. Infect Immun. 2007 May; 75(5):2562-71.
Furukawa M, Ebmeyer J, Pak K, Austin DA, Melhus A, Webster NJ, Ryan AF. PMID: 17325051; PMCID: PMC1865762.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
-
A PI3K pathway mediates hair cell survival and opposes gentamicin toxicity in neonatal rat organ of Corti. J Assoc Res Otolaryngol. 2006 Dec; 7(4):373-82.
Chung WH, Pak K, Lin B, Webster N, Ryan AF. PMID: 17053865; PMCID: PMC2504631.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
-
Mouse models of induced otitis media. Brain Res. 2006 May 26; 1091(1):3-8.
Ryan AF, Ebmeyer J, Furukawa M, Pak K, Melhus A, Wasserman SI, Chung WH. PMID: 16764829.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimals
-
Environmental micro-patterning for the study of spiral ganglion neurite guidance. Audiol Neurootol. 2006; 11(2):134-43.
Ryan AF, Wittig J, Evans A, Dazert S, Mullen L. PMID: 16439836.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
-
Developmentally regulated expression of the P2X3 receptor in the mouse cochlea. Histochem Cell Biol. 2006 Jun; 125(6):681-92.
Huang LC, Ryan AF, Cockayne DA, Housley GD. PMID: 16341871.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
-
Role of mast cells in otitis media. J Allergy Clin Immunol. 2005 Nov; 116(5):1129-35.
Ebmeyer J, Furukawa M, Pak K, Ebmeyer U, Sudhoff H, Broide D, Ryan AF, Wasserman S. PMID: 16275387.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
-
The role of Fas-mediated apoptosis in otitis media: observations in the lpr/lpr mouse. Hear Res. 2005 Sep; 207(1-2):110-6.
Rivkin AZ, Palacios SD, Pak K, Bennett T, Ryan AF. PMID: 15978756.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
-
Recent advances in otitis media. 4B. Biochemistry. Ann Otol Rhinol Laryngol Suppl. 2005 Jan; 194:50-5.
Ryan AF, Jung TT, Juhn SK, Li JD, Andalibi A, Lin J, Bakaletz LO, Post CJ, Ehrlich GD. PMID: 15700935.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
-
Recent advances in otitis media. 4C. Interaction between middle ear and inner ear in otitis media. Ann Otol Rhinol Laryngol Suppl. 2005 Jan; 194:56-9.
Ryan AF, Jung TT, Juhn SK, Li JD, Andalibi A, Lin J, Bakaletz LO, Post CJ, Ehrlich GD. PMID: 15700936.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
-
Recent advances in otitis media. 4A. Molecular biology. Ann Otol Rhinol Laryngol Suppl. 2005 Jan; 194:42-9.
Ryan AF, Jung TT, Juhn SK, Li JD, Andalibi A, Lin J, Bakaletz LO, Post CJ, Ehrlich GD. PMID: 15700934.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
-
A reusable microfluidic plate with alternate-choice architecture for assessing growth preference in tissue culture. J Neurosci Methods. 2005 May 15; 144(1):79-89.
Wittig JH, Ryan AF, Asbeck PM. PMID: 15848242.
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PubMed Mentions:
14 Fields:
Translation:
Animals
-
Role of p38 mitogen-activated protein kinase in middle ear mucosa hyperplasia during bacterial otitis media. Infect Immun. 2004 Aug; 72(8):4662-7.
Palacios SD, Pak K, Rivkin AZ, Kayali AG, Austen D, Aletsee C, Melhus A, Webster NJ, Ryan AF. PMID: 15271927; PMCID: PMC470656.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
-
Effects of amoxicillin on cytokine and osteocalcin expression in bone tissue during experimental acute otitis media. Cytokine. 2004 Mar 21; 25(6):254-9.
Melhus A, Ryan AF. PMID: 15036240.
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PubMed Mentions:
1 Translation:
AnimalsCells
-
Rapid muscle-specific gene expression changes after a single bout of eccentric contractions in the mouse. Am J Physiol Cell Physiol. 2004 Feb; 286(2):C355-64.
Barash IA, Mathew L, Ryan AF, Chen J, Lieber RL. PMID: 14561590.
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PubMed Mentions:
64 Fields:
Translation:
AnimalsCells
-
A mouse model for acute otitis media. APMIS. 2003 Oct; 111(10):989-94.
Melhus A, Ryan AF. PMID: 14616553.
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PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
-
Fas ligand expression in the organ of Corti. Audiol Neurootol. 2003 Sep-Oct; 8(5):243-9.
Bodmer D, Brors D, Bodmer M, Pak K, Ryan AF. PMID: 12904679.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
EphA4 provides repulsive signals to developing cochlear ganglion neurites mediated through ephrin-B2 and -B3. J Comp Neurol. 2003 Jul 14; 462(1):90-100.
Brors D, Bodmer D, Pak K, Aletsee C, Schäfers M, Dazert S, Ryan AF. PMID: 12761826.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
-
Noise induces up-regulation of P2X2 receptor subunit of ATP-gated ion channels in the rat cochlea. Neuroreport. 2003 May 06; 14(6):817-23.
Wang JC, Raybould NP, Luo L, Ryan AF, Cannell MB, Thorne PR, Housley GD. PMID: 12858039.
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PubMed Mentions:
35 Fields:
Translation:
AnimalsCellsPHPublic Health
-
Branching of spiral ganglion neurites is induced by focal application of fibroblast growth factor-1. Laryngoscope. 2003 May; 113(5):791-6.
Aletsee C, Brors D, Mlynski R, Ryan AF, Dazert S. PMID: 12792312.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
Gentamicin-induced hair cell death is not dependent on the apoptosis receptor Fas. Laryngoscope. 2003 Mar; 113(3):452-5.
Bodmer D, Brors D, Pak K, Bodmer M, Ryan AF. PMID: 12616196.
View in:
PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
-
Contribution of BK Ca2+-activated K+ channels to auditory neurotransmission in the Guinea pig cochlea. J Neurophysiol. 2003 Jul; 90(1):320-32.
Skinner LJ, Enée V, Beurg M, Jung HH, Ryan AF, Hafidi A, Aran JM, Dulon D. PMID: 12611976.
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PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
-
Clostridium difficile toxin B, an inhibitor of the small GTPases Rho, Rac and Cdc42, influences spiral ganglion neurite outgrowth. Acta Otolaryngol. 2003 Jan; 123(1):20-5.
Brors D, Aletsee C, Dazert S, Huverstuhl J, Ryan AF, Bodmer D. PMID: 12625568.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
The cell cycle and the development and regeneration of hair cells. Curr Top Dev Biol. 2003; 57:449-66.
Ryan AF. PMID: 14674489.
View in:
PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
-
Participation of Ras and extracellular regulated kinase in the hyperplastic response of middle-ear mucosa during bacterial otitis media. J Infect Dis. 2002 Dec 15; 186(12):1761-9.
Palacios SD, Pak K, Kayali AG, Rivkin AZ, Aletsee C, Melhus A, Webster NJ, Ryan AF. PMID: 12447762.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
-
Induction of MHC class II antigens on cells of the inner ear. Audiol Neurootol. 2002 Nov-Dec; 7(6):317-23.
Gloddek B, Bodmer D, Brors D, Keithley EM, Ryan AF. PMID: 12463193.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Inhibition of the c-Jun N-terminal kinase signaling pathway influences neurite outgrowth of spiral ganglion neurons in vitro. Laryngoscope. 2002 Nov; 112(11):2057-61.
Bodmer D, Gloddek B, Ryan AF, Huverstuhl J, Brors D. PMID: 12439181.
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PubMed Mentions:
14 Fields:
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AnimalsCells
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Rescue of auditory hair cells from aminoglycoside toxicity by Clostridium difficile toxin B, an inhibitor of the small GTPases Rho/Rac/Cdc42. Hear Res. 2002 Oct; 172(1-2):81-6.
Bodmer D, Brors D, Pak K, Gloddek B, Ryan A. PMID: 12361869.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Inflammatory signals increase Fas ligand expression by inner ear cells. J Neuroimmunol. 2002 Aug; 129(1-2):10-7.
Bodmer D, Brors D, Pak K, Keithley EM, Mullen L, Ryan AF, Gloddek B. PMID: 12161015.
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PubMed Mentions:
7 Fields:
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AnimalsCells
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Molecular studies of hair cell development and survival. Audiol Neurootol. 2002 May-Jun; 7(3):138-40.
Ryan AF. PMID: 12053133.
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PubMed Mentions:
1 Fields:
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AnimalsCells
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Interaction of spiral ganglion neuron processes with alloplastic materials in vitro(1). Hear Res. 2002 May; 167(1-2):110-21.
Brors D, Aletsee C, Schwager K, Mlynski R, Hansen S, Schäfers M, Ryan AF, Dazert S. PMID: 12117535.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Growth factors and their receptors in the middle ear mucosa during otitis media. Laryngoscope. 2002 Mar; 112(3):420-3.
Palacios SD, Pak K, Rivkin AZ, Bennett T, Ryan AF. PMID: 12148846.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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The effects of laminin-1 on spiral ganglion neurons are dependent on the MEK/ERK signaling pathway and are partially independent of Ras. Hear Res. 2002 Feb; 164(1-2):1-11.
Aletsee C, Brors D, Palacios S, Pak K, Mullen L, Dazert S, Ryan AF. PMID: 11950519.
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PubMed Mentions:
7 Fields:
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AnimalsCells
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Immunological damage to the inner ear: current and future therapeutic strategies. Adv Otorhinolaryngol. 2002; 59:66-74.
Ryan AF, Pak K, Low W, Battaglia A, Mullen L, Harris JP, Keithley EM. PMID: 11885663.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Immune-mediated hearing loss: basic mechanisms and options for therapy. Acta Otolaryngol Suppl. 2002; (548):38-43.
Ryan AF, Harris JP, Keithley EM. PMID: 12211356.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Nitric oxide contributes to control of effusion in experimental otitis media. Laryngoscope. 2001 Feb; 111(2):301-5.
Ryan AF, Bennett T. PMID: 11210879.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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Lymphocyte trafficking to the inner ear. Ann N Y Acad Sci. 1997 Dec 29; 830:236-42.
Ryan AF, Gloddek B, Harris JP. PMID: 9616682.
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HumansAnimalsCells
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Summary: progress in inner-ear immunology. Ann N Y Acad Sci. 1997 Dec 29; 830:326-9.
Ryan AF. PMID: 9616693.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals