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Allen Ryan

Title(s)Recall Faculty, Surgery
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0666
La Jolla CA 92093
Phone8/5-34--4594
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    Research Overview

    Biology of the inner and middle ears, including hair cell gene and fate regulation, drug and noise damage to hearing, inner ear neuronal targeting, pathogenesis and recovery mechanisms in otitis media, and drug delivery to the middle and inner ears.

    Research Topics

    • Cell Biology

    • Development

    • Drug Delivery

    • Genomics

    • Immunology

    • Infectious Disease

    • Inflammation

    • Injury

    • Innate Immunity

    • Molecular Biology

    • Neuroscience

    • Regeneration/Stem Cells

    • Structural Biology

    • Translational Research


    Current Project Titles

    • Recovery from blast-induced hearing loss (DoD)

    • A biological interface for the cochlear implant (VA)

    • Middle ear responses in otitis media (NIH)

    • Mechanisms of persistence and recovery in otitis media (NIH)

    • New methods for the treatment of hearing and balance disorders (Pending)



    Profile

    My laboratory studies the basic biology of hearing. A major focus of the group is the sensory hair cells of the cochlea. This includes studies of gene regulation in these cells, as well as fate determination by combinatorial transcription factor coding. We also study cellular mechanisms of hair cell damage and death induced by ototoxic drugs, noise trauma and excitotoxicity. A second area of interest is the two types of afferent neurons in the cochlea. In particular the type II neurons that innervate outer hair cells are poorly understood with respect to their function and the regulation of their complex pathfinding to their target hair cells. We also study pathogenesis and recovery of the middle ear mucosa during otitis media, with a focus on cell phenotype determination and innate immunity. Finally, we are interested in novel methods for drug delivery to the middle and inner ears.

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    Collapse Research Activities and Funding
    Genome-wide association study of tinnitus in the Million Veterans Program with emphasis on traumatic brain injury
    VA I01RX002744Feb 1, 2019 - Oct 31, 2020
    Role: Principal Investigator
    A Biological Interface for Auditory Rehabilitation with a Cochlear Implant
    VA I01RX000977Oct 1, 2013 - Sep 30, 2016
    Role: Principal Investigator
    Basic Mechanisms in Hearing Loss of Cochlear Origin
    VA I01BX001205Oct 1, 2012 - Sep 30, 2020
    Role: Principal Investigator
    Innovative therapy for diseases of the middle ear
    NIH/NIDCD R01DC012595Jul 1, 2012 - Jun 30, 2017
    Role: Principal Investigator
    The 8th Conference on the Molecular Biology of Hearing &Deafness
    NIH/NIDCD R13DC012023Jul 4, 2011 - Jun 30, 2014
    Role: Principal Investigator
    Conference on Molecular Biology of Hearing and Deafness
    NIH/NIDCD R13DC010087Mar 1, 2009 - Feb 28, 2010
    Role: Principal Investigator
    Conference on the Molecular Biology of Hearing/Deafness
    NIH/NIDCD R13DC007068Sep 1, 2004 - Aug 31, 2005
    Role: Principal Investigator
    CONFERENCE ON MOLECULAR BIOLOGY OF HEARING AND DEAFNESS
    NIH/NIDCD R13DC005016Sep 1, 2001 - Aug 31, 2002
    Role: Principal Investigator
    MOLECULAR BIOLOGY OF HEARING AND DEAFNESS CONFERENCE
    NIH/NIDCD R13DC003804Aug 1, 1998 - Jan 31, 1999
    Role: Principal Investigator
    CONF ON THE MOLECULAR BIOLOGY OF HEARING AND DEAFNESS
    NIH/NIDCD R13DC002735Jul 1, 1995 - Jun 30, 1996
    Role: Principal Investigator
    CONF. ON THE MOLECULAR BIOLOGY HEARING AND DEAFNESS
    NIH/NIDCD R13DC001516May 1, 1992 - Apr 30, 1993
    Role: Principal Investigator
    Middle Ear Response in Otitis Media
    NIH/NIDCD R01DC000129Apr 1, 1990 - Mar 31, 2011
    Role: Principal Investigator
    Otolaryngology Training in Immunology, Virology and Molecular Biology
    NIH/NIDCD T32DC000028Jul 10, 1989 - Jun 30, 2021
    Role: Principal Investigator
    ENVIRONMENT INFLUENCES UPON AUDITORY DEVELOPMENT
    NIH/NIDCD R01DC000139Jul 1, 1979 - Mar 31, 1996
    Role: Principal Investigator
    ENVIRONMENTAL INFLUENCES UPON AUDITORY DEVELOPMENT
    NIH/NINDS R01NS014945Jul 1, 1979 - Mar 31, 1989
    Role: Principal Investigator
    MIDDLE EAR RESPONSE IN SEROUS OTITIS MEDIA
    NIH/NINDS R01NS014389Apr 1, 1978 - Mar 31, 1990
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Multi-omic studies on missense PLG variants in families with otitis media. Sci Rep. 2020 Sep 14; 10(1):15035. Bootpetch TC, Hafrén L, Elling CL, Baschal EE, Manichaikul AW, Pine HS, Szeremeta W, Scholes MA, Cass SP, Larson ED, Chan KH, Ishaq R, Prager JD, Shaikh RS, Gubbels SP, Yousaf A, Wine TM, Bamshad MJ, Yoon PJ, Jenkins HA, Nickerson DA, Streubel SO, Friedman NR, Frank DN, Einarsdottir E, Kere J, Riazuddin S, Daly KA, Leal SM, Ryan AF, Mattila PS, Ahmed ZM, Sale MM, Chonmaitree T, Santos-Cortez RLP. PMID: 32929111.
      View in: PubMed   Mentions:
    2. A kinase inhibitor screen identifies signaling pathways regulating mucosal growth during otitis media. PLoS One. 2020; 15(8):e0235634. Noel J, Suzukawa K, Chavez E, Pak K, Wasserman SI, Kurabi A, Ryan AF. PMID: 32760078.
      View in: PubMed   Mentions:    Fields:    
    3. Otitis media susceptibility and shifts in the head and neck microbiome due to SPINK5 variants. J Med Genet. 2020 Jul 24. Frank DN, Giese APJ, Hafren L, Bootpetch TC, Yarza TKL, Steritz MJ, Pedro M, Labra PJ, Daly KA, Tantoco MLC, Szeremeta W, Reyes-Quintos MRT, Ahankoob N, Llanes EGDV, Pine HS, Yousaf S, Ir D, Einarsdottir E, de la Cruz RAR, Lee NR, Nonato RMA, Robertson CE, Ong KMC, Magno JPM, Chiong ANE, Espiritu-Chiong MC, San Agustin ML, Cruz TLG, Abes GT, Bamshad MJ, Cutiongco-de la Paz EM, Kere J, Nickerson DA, Mohlke KL, Riazuddin S, Chan A, Mattila PS, Leal SM, Ryan AF, Ahmed ZM, Chonmaitree T, Sale MM, Chiong CM, Santos-Cortez RLP. PMID: 32709676.
      View in: PubMed   Mentions:    Fields:    
    4. Macrophage depletion in CCR2-/- mice delays bacterial clearance and enhances neutrophil infiltration in an acute otitis media model. J Infect Dis. 2020 Jun 23. Hur DG, Kurabi A, Lim HW, Spriggs M, Pak K, Ryan AF. PMID: 32572481.
      View in: PubMed   Mentions:    Fields:    
    5. Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection. Front Genet. 2020; 11:358. Ryan AF, Nasamran CA, Pak K, Draf C, Fisch KM, Webster N, Kurabi A. PMID: 32351546.
      View in: PubMed   Mentions:
    6. Panel 1: Biotechnology, biomedical engineering and new models of otitis media. Int J Pediatr Otorhinolaryngol. 2020 Mar; 130 Suppl 1:109833. Gisselsson-Solén M, Tähtinen PA, Ryan AF, Mulay A, Kariya S, Schilder AGM, Valdez TA, Brown S, Nolan RM, Hermansson A, van Ingen G, Marom T. PMID: 31901291.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. Panel 3: Genomics, precision medicine and targeted therapies. Int J Pediatr Otorhinolaryngol. 2020 Mar; 130 Suppl 1:109835. Santos-Cortez RLP, Bhutta MF, Earl JP, Hafrén L, Jennings M, Mell JC, Pichichero ME, Ryan AF, Tateossian H, Ehrlich GD. PMID: 32007292.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    8. Role of the PI3K/AKT pathway and PTEN in otitis media. Exp Cell Res. 2020 Feb 01; 387(1):111758. Lee HH, Chin A, Pak K, Wasserman SI, Kurabi A, Ryan AF. PMID: 31837294.
      View in: PubMed   Mentions: 1     Fields:    
    9. Inflammation associated with noise-induced hearing loss. J Acoust Soc Am. 2019 11; 146(5):4020. Frye MD, Ryan AF, Kurabi A. PMID: 31795714.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    10. Onset kinetics of noise-induced purinergic adaptation of the 'cochlear amplifier'. Purinergic Signal. 2019 09; 15(3):343-355. Cederholm JME, Ryan AF, Housley GD. PMID: 31377959.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCellsPHPublic Health
    11. Lack of the hyaluronan receptor CD44 affects the course of bacterial otitis media and reduces leukocyte recruitment to the middle ear. BMC Immunol. 2019 06 21; 20(1):20. Lim HW, Pak K, Kurabi A, Ryan AF. PMID: 31226944.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    12. FUT2 Variants Confer Susceptibility to Familial Otitis Media. Am J Hum Genet. 2018 11 01; 103(5):679-690. Santos-Cortez RLP, Chiong CM, Frank DN, Ryan AF, Giese APJ, Bootpetch Roberts T, Daly KA, Steritz MJ, Szeremeta W, Pedro M, Pine H, Yarza TKL, Scholes MA, Llanes EGDV, Yousaf S, Friedman N, Tantoco MLC, Wine TM, Labra PJ, Benoit J, Ruiz AG, de la Cruz RAR, Greenlee C, Yousaf A, Cardwell J, Nonato RMA, Ray D, Ong KMC, So E, Robertson CE, Dinwiddie J, Lagrana-Villagracia SM, Gubbels SP, Shaikh RS, Cass SP, Einarsdottir E, Lee NR, Schwartz DA, Gloria-Cruz TLI, Bamshad MJ, Yang IV, Kere J, Abes GT, Prager JD, Riazuddin S, Chan AL, Yoon PJ, Nickerson DA, Cutiongco-de la Paz EM, Streubel SO, Reyes-Quintos MRT, Jenkins HA, Mattila P, Chan KH, Mohlke KL, Leal SM, Hafrén L, Chonmaitree T, Sale MM, Ahmed ZM. PMID: 30401457.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    13. Active Transport of Peptides Across the Intact Human Tympanic Membrane. Sci Rep. 2018 08 07; 8(1):11815. Kurabi A, Schaerer D, Noack V, Bernhardt M, Pak K, Alexander T, Husseman J, Nguyen Q, Harris JP, Ryan AF. PMID: 30087425.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    14. Screening Mammalian Cochlear Hair Cells to Identify Critical Processes in Aminoglycoside-Mediated Damage. Front Cell Neurosci. 2018; 12:179. Lim HW, Pak K, Ryan AF, Kurabi A. PMID: 30013464.
      View in: PubMed   Mentions:
    15. Screening antioxidants for the protection of cochlear sensory cells. Neural Regen Res. 2018 Jan; 13(1):62-64. Hur DG, Kurabi A, Ryan AF. PMID: 29451206.
      View in: PubMed   Mentions:
    16. A kinase inhibitor library screen identifies novel enzymes involved in ototoxic damage to the murine organ of Corti. PLoS One. 2017; 12(10):e0186001. Ryals M, Pak K, Jalota R, Kurabi A, Ryan AF. PMID: 29049311.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    17. Otitis Media and Nasopharyngeal Colonization in ccl3-/- Mice. Infect Immun. 2017 11; 85(11). Deniffel D, Nuyen B, Pak K, Suzukawa K, Hung J, Kurabi A, Wasserman SI, Ryan AF. PMID: 28847849.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    18. An Antioxidant Screen Identifies Candidates for Protection of Cochlear Hair Cells from Gentamicin Toxicity. Front Cell Neurosci. 2017; 11:242. Noack V, Pak K, Jalota R, Kurabi A, Ryan AF. PMID: 28867994.
      View in: PubMed   Mentions:
    19. Optimisation of peptides that actively cross the tympanic membrane by random amino acid extension: a phage display study. J Drug Target. 2018 02; 26(2):127-134. Kurabi A, Schaerer D, Chang L, Pak K, Ryan AF. PMID: 28658990.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    20. Panel 5: Immunology. Otolaryngol Head Neck Surg. 2017 04; 156(4_suppl):S63-S75. Kyd JM, Hotomi M, Kono M, Kurabi A, Pichichero M, Ryan A, Swords WE, Thornton R. PMID: 28372530.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Peptides actively transported across the tympanic membrane: Functional and structural properties. PLoS One. 2017; 12(2):e0172158. Kurabi A, Beasley KA, Chang L, McCann J, Pak K, Ryan AF. PMID: 28234923.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    22. Global Analysis of Protein Expression of Inner Ear Hair Cells. J Neurosci. 2017 02 01; 37(5):1320-1339. Hickox AE, Wong AC, Pak K, Strojny C, Ramirez M, Yates JR, Ryan AF, Savas JN. PMID: 28039372.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    23. Cellular mechanisms of noise-induced hearing loss. Hear Res. 2017 06; 349:129-137. Kurabi A, Keithley EM, Housley GD, Ryan AF, Wong AC. PMID: 27916698.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    24. Both canonical and non-canonical NF-?B activation contribute to the proliferative response of the middle ear mucosa during bacterial infection. Innate Immun. 2016 11; 22(8):626-634. Cho CG, Pak K, Webster N, Kurabi A, Ryan AF. PMID: 27655045.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    25. The Promoter and Multiple Enhancers of the pou4f3 Gene Regulate Expression in Inner Ear Hair Cells. Mol Neurobiol. 2017 09; 54(7):5414-5426. Masuda M, Li Y, Pak K, Chavez E, Mullen L, Ryan AF. PMID: 27592349.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    26. Temporary and Permanent Noise-induced Threshold Shifts: A Review of Basic and Clinical Observations. Otol Neurotol. 2016 09; 37(8):e271-5. Ryan AF, Kujawa SG, Hammill T, Le Prell C, Kil J. PMID: 27518135.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsPHPublic Health
    27. Impulse Noise Injury Model. Mil Med. 2016 05; 181(5 Suppl):59-69. Chan P, Ho K, Ryan AF. PMID: 27168554.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    28. Discovery of a Biological Mechanism of Active Transport through the Tympanic Membrane to the Middle Ear. Sci Rep. 2016 Mar 07; 6:22663. Kurabi A, Pak KK, Bernhardt M, Baird A, Ryan AF. PMID: 26946957.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    29. Innate Immunity: Orchestrating Inflammation and Resolution of Otitis Media. Curr Allergy Asthma Rep. 2016 Jan; 16(1):6. Kurabi A, Pak K, Ryan AF, Wasserman SI. PMID: 26732809.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    30. Tinnitus: Research supported by the Tinnitus Research Consortium. Hear Res. 2016 04; 334:1. Ryan AF, Dobie RA, Dubno JR, Lonsbury-Martin BL. PMID: 26739791.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    31. The Sustained-Exposure Dexamethasone Formulation OTO-104 Offers Effective Protection against Noise-Induced Hearing Loss. Audiol Neurootol. 2016; 21(1):12-21. Harrop-Jones A, Wang X, Fernandez R, Dellamary L, Ryan AF, LeBel C, Piu F. PMID: 26655654.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    32. Properties of ATP-gated ion channels assembled from P2X2 subunits in mouse cochlear Reissner's membrane epithelial cells. Purinergic Signal. 2015 Dec; 11(4):551-60. Morton-Jones RT, Vlajkovic SM, Thorne PR, Cockayne DA, Ryan AF, Housley GD. PMID: 26424615.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    33. Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier. Nat Commun. 2015 May 12; 6:7115. Froud KE, Wong AC, Cederholm JM, Klugmann M, Sandow SL, Julien JP, Ryan AF, Housley GD. PMID: 25965946.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    34. Mechanisms of sensorineural cell damage, death and survival in the cochlea. Front Aging Neurosci. 2015; 7:58. Wong AC, Ryan AF. PMID: 25954196.
      View in: PubMed   Mentions:
    35. The transcriptome of a complete episode of acute otitis media. BMC Genomics. 2015 Apr 03; 16:259. Hernandez M, Leichtle A, Pak K, Webster NJ, Wasserman SI, Ryan AF. PMID: 25888408.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    36. NOD-Like Receptor Signaling in Cholesteatoma. Biomed Res Int. 2015; 2015:408169. Leichtle A, Klenke C, Ebmeyer J, Daerr M, Bruchhage KL, Hoffmann AS, Ryan AF, Wollenberg B, Sudhoff H. PMID: 25922834.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    37. Transcription factors with conserved binding sites near ATOH1 on the POU4F3 gene enhance the induction of cochlear hair cells. Mol Neurobiol. 2015 Apr; 51(2):672-84. Ikeda R, Pak K, Chavez E, Ryan AF. PMID: 25015561.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    38. All Akt isoforms (Akt1, Akt2, Akt3) are involved in normal hearing, but only Akt2 and Akt3 are involved in auditory hair cell survival in the mammalian inner ear. PLoS One. 2015; 10(3):e0121599. Brand Y, Levano S, Radojevic V, Naldi AM, Setz C, Ryan AF, Pak K, Hemmings BA, Bodmer D. PMID: 25811375.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    39. The regulation of gene expression in hair cells. Hear Res. 2015 Nov; 329:33-40. Ryan AF, Ikeda R, Masuda M. PMID: 25616095.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    40. Neural cell adhesion molecule NrCAM is expressed in the mammalian inner ear and modulates spiral ganglion neurite outgrowth in an in vitro alternate choice assay. J Mol Neurosci. 2015 Apr; 55(4):836-44. Brand Y, Sung M, Pak K, Chavez E, Wei E, Radojevic V, Bodmer D, Ryan AF. PMID: 25407819.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    41. Skeletal muscle intermediate filaments form a stress-transmitting and stress-signaling network. J Cell Sci. 2015 Jan 15; 128(2):219-24. Palmisano MG, Bremner SN, Hornberger TA, Meyer GA, Domenighetti AA, Shah SB, Kiss B, Kellermayer M, Ryan AF, Lieber RL. PMID: 25413344.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    42. C-Jun N-terminal kinase (JNK) isoforms play differing roles in otitis media. BMC Immunol. 2014 Oct 14; 15:46. Yao W, Frie M, Pan J, Pak K, Webster N, Wasserman SI, Ryan AF. PMID: 25311344.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    43. A mouse model of otitis media identifies HB-EGF as a mediator of inflammation-induced mucosal proliferation. PLoS One. 2014; 9(7):e102739. Suzukawa K, Tomlin J, Pak K, Chavez E, Kurabi A, Baird A, Wasserman SI, Ryan AF. PMID: 25033458.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    44. Inhibition of MMP-2 but not MMP-9 influences inner ear spiral ganglion neurons in vitro. Cell Mol Neurobiol. 2014 Oct; 34(7):1011-21. Sung M, Wei E, Chavez E, Jain N, Levano S, Binkert L, Ramseier A, Setz C, Bodmer D, Ryan AF, Brand Y. PMID: 24935409.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    45. The inflammasome adaptor ASC contributes to multiple innate immune processes in the resolution of otitis media. Innate Immun. 2015 Feb; 21(2):203-14. Kurabi A, Lee J, Wong C, Pak K, Hoffman HM, Ryan AF, Wasserman SI. PMID: 24652041.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    46. Neural cell adhesion molecule L1 modulates type I but not type II inner ear spiral ganglion neurite outgrowth in an in vitro alternate choice assay. J Mol Neurosci. 2013 Nov; 51(3):663-70. Brand Y, Sung M, Chavez E, Wei E, Pak KK, Housley GD, Bodmer D, Ryan AF. PMID: 23760987.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    47. Ecrg4 attenuates the inflammatory proliferative response of mucosal epithelial cells to infection. PLoS One. 2013; 8(4):e61394. Kurabi A, Pak K, Dang X, Coimbra R, Eliceiri BP, Ryan AF, Baird A. PMID: 23626679.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    48. ATP-gated ion channels mediate adaptation to elevated sound levels. Proc Natl Acad Sci U S A. 2013 Apr 30; 110(18):7494-9. Housley GD, Morton-Jones R, Vlajkovic SM, Telang RS, Paramananthasivam V, Tadros SF, Wong AC, Froud KE, Cederholm JM, Sivakumaran Y, Snguanwongchai P, Khakh BS, Cockayne DA, Thorne PR, Ryan AF. PMID: 23592720.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCellsPHPublic Health
    49. Panel 4: Recent advances in otitis media in molecular biology, biochemistry, genetics, and animal models. Otolaryngol Head Neck Surg. 2013 Apr; 148(4 Suppl):E52-63. Li JD, Hermansson A, Ryan AF, Bakaletz LO, Brown SD, Cheeseman MT, Juhn SK, Jung TT, Lim DJ, Lim JH, Lin J, Moon SK, Post JC. PMID: 23536532.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    50. Changes in responsiveness of rat spiral ganglion neurons to neurotrophins across age: differential regulation of survival and neuritogenesis. Int J Neurosci. 2013 Jul; 123(7):465-75. Kondo K, Pak K, Chavez E, Mullen L, Euteneuer S, Ryan AF. PMID: 23301942.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    51. Mutation of the ATP-gated P2X(2) receptor leads to progressive hearing loss and increased susceptibility to noise. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2228-33. Yan D, Zhu Y, Walsh T, Xie D, Yuan H, Sirmaci A, Fujikawa T, Wong AC, Loh TL, Du L, Grati M, Vlajkovic SM, Blanton S, Ryan AF, Chen ZY, Thorne PR, Kachar B, Tekin M, Zhao HB, Housley GD, King MC, Liu XZ. PMID: 23345450.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    52. Neurotrophins differentially stimulate the growth of cochlear neurites on collagen surfaces and in gels. Neural Regen Res. 2013; 8(17):1541-1550. Xie J, Pak K, Evans A, Kamgar-Parsi A, Fausti S, Mullen L, Ryan AF. PMID: 24459465.
      View in: PubMed   Mentions:
    53. Glial cell line-derived neurotrophic factor (GDNF) induces neuritogenesis in the cochlear spiral ganglion via neural cell adhesion molecule (NCAM). Mol Cell Neurosci. 2013 May; 54:30-43. Euteneuer S, Yang KH, Chavez E, Leichtle A, Loers G, Olshansky A, Pak K, Schachner M, Ryan AF. PMID: 23262364.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    54. Developmental changes in the responsiveness of rat spiral ganglion neurons to neurotrophic factors in dissociated culture: differential responses for survival, neuritogenesis and neuronal morphology. Cell Tissue Res. 2013 Jan; 351(1):15-27. Jin Y, Kondo K, Ushio M, Kaga K, Ryan AF, Yamasoba T. PMID: 23149719.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    55. TFE2 and GATA3 enhance induction of POU4F3 and myosin VIIa positive cells in nonsensory cochlear epithelium by ATOH1. Dev Biol. 2012 Dec 01; 372(1):68-80. Masuda M, Pak K, Chavez E, Ryan AF. PMID: 22985730.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    56. Differential actions of isoflurane and ketamine-based anaesthetics on cochlear function in the mouse. Hear Res. 2012 Oct; 292(1-2):71-9. Cederholm JM, Froud KE, Wong AC, Ko M, Ryan AF, Housley GD. PMID: 22960466.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    57. Systemic immunity influences hearing preservation in cochlear implantation. Otol Neurotol. 2012 Jun; 33(4):532-8. Souter M, Eastwood H, Marovic P, Kel G, Wongprasartsuk S, Ryan AF, O'Leary SJ. PMID: 22470051.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    58. The role of vascular endothelial growth factors and fibroblast growth factors in angiogenesis during otitis media. Audiol Neurootol. 2012; 17(3):148-54. Husseman J, Palacios SD, Rivkin AZ, Oehl H, Ryan AF. PMID: 22104377.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    59. Simvastatin protects auditory hair cells from gentamicin-induced toxicity and activates Akt signaling in vitro. BMC Neurosci. 2011 Nov 14; 12:114. Brand Y, Setz C, Levano S, Listyo A, Chavez E, Pak K, Sung M, Radojevic V, Ryan AF, Bodmer D. PMID: 22082490.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    60. Ras/p38 and PI3K/Akt but not Mek/Erk signaling mediate BDNF-induced neurite formation on neonatal cochlear spiral ganglion explants. Brain Res. 2012 Jan 09; 1430:25-34. Mullen LM, Pak KK, Chavez E, Kondo K, Brand Y, Ryan AF. PMID: 22119396.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    61. Type I vs type II spiral ganglion neurons exhibit differential survival and neuritogenesis during cochlear development. Neural Dev. 2011 Oct 11; 6:33. Barclay M, Ryan AF, Housley GD. PMID: 21989106.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    62. ErbB expression, activation, and inhibition with lapatinib and tyrphostin (AG825) in human vestibular schwannomas. Otol Neurotol. 2011 Jul; 32(5):841-7. Ahmad ZK, Brown CM, Cueva RA, Ryan AF, Doherty JK. PMID: 21659924.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    63. Innate signaling in otitis media: pathogenesis and recovery. Curr Allergy Asthma Rep. 2011 Feb; 11(1):78-84. Leichtle A, Lai Y, Wollenberg B, Wasserman SI, Ryan AF. PMID: 21049294.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    64. TNFA deletion alters apoptosis as well as caspase 3 and 4 expression during otitis media. BMC Immunol. 2011 Jan 26; 12:12. Ebmeyer J, Leichtle A, Hernandez M, Ebmeyer U, Husseman J, Pak K, Sudhoff H, Broide D, Wasserman SI, Ryan AF. PMID: 21269505.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    65. The role of DNA sensing and innate immune receptor TLR9 in otitis media. Innate Immun. 2012 Feb; 18(1):3-13. Leichtle A, Hernandez M, Lee J, Pak K, Webster NJ, Wollenberg B, Wasserman SI, Ryan AF. PMID: 21239460.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    66. Estrogen receptor expression in sporadic vestibular schwannomas. Otol Neurotol. 2011 Jan; 32(1):158-62. Brown CM, Ahmad ZK, Ryan AF, Doherty JK. PMID: 21099731.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    67. Activation of TLR2 by a small molecule produced by Staphylococcus epidermidis increases antimicrobial defense against bacterial skin infections. J Invest Dermatol. 2010 Sep; 130(9):2211-21. Lai Y, Cogen AL, Radek KA, Park HJ, Macleod DT, Leichtle A, Ryan AF, Di Nardo A, Gallo RL. PMID: 20463690.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    68. Merlin knockdown in human Schwann cells: clues to vestibular schwannoma tumorigenesis. Otol Neurotol. 2010 Apr; 31(3):460-6. Ahmad Z, Brown CM, Patel AK, Ryan AF, Ongkeko R, Doherty JK. PMID: 20195187.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    69. CC chemokine ligand 3 overcomes the bacteriocidal and phagocytic defect of macrophages and hastens recovery from experimental otitis media in TNF-/- mice. J Immunol. 2010 Mar 15; 184(6):3087-97. Leichtle A, Hernandez M, Ebmeyer J, Yamasaki K, Lai Y, Radek K, Choung YH, Euteneuer S, Pak K, Gallo R, Wasserman SI, Ryan AF. PMID: 20164426.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    70. Type III intermediate filament peripherin inhibits neuritogenesis in type II spiral ganglion neurons in vitro. Neurosci Lett. 2010 Jul 05; 478(2):51-5. Barclay M, Julien JP, Ryan AF, Housley GD. PMID: 20132868.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    71. Reconstitution of the mast cell population in W/Wv mice. Otol Neurotol. 2010 Jan; 31(1):42-7. Ebmeyer J, Ebmeyer U, Pak K, Sudhoff H, Broide D, Ryan AF, Wasserman S. PMID: 19752767.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    72. Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury. Nat Med. 2009 Dec; 15(12):1377-82. Lai Y, Di Nardo A, Nakatsuji T, Leichtle A, Yang Y, Cogen AL, Wu ZR, Hooper LV, Schmidt RR, von Aulock S, Radek KA, Huang CM, Ryan AF, Gallo RL. PMID: 19966777.
      View in: PubMed   Mentions: 185     Fields:    Translation:Humans
    73. The toll-Like receptor adaptor TRIF contributes to otitis media pathogenesis and recovery. BMC Immunol. 2009 Aug 05; 10:45. Leichtle A, Hernandez M, Pak K, Webster NJ, Wasserman SI, Ryan AF. PMID: 19656404.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    74. TLR4-mediated induction of TLR2 signaling is critical in the pathogenesis and resolution of otitis media. Innate Immun. 2009 Aug; 15(4):205-15. Leichtle A, Hernandez M, Pak K, Yamasaki K, Cheng CF, Webster NJ, Ryan AF, Wasserman SI. PMID: 19586996.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    75. Gene therapy for the inner ear: challenges and promises. Adv Otorhinolaryngol. 2009; 66:1-12. Ryan AF, Dazert S. PMID: 19494569.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    76. Cellular targeting for cochlear gene therapy. Adv Otorhinolaryngol. 2009; 66:99-115. Ryan AF, Mullen LM, Doherty JK. PMID: 19494575.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    77. Myeloid differentiation primary response gene 88 is required for the resolution of otitis media. J Infect Dis. 2008 Dec 15; 198(12):1862-9. Hernandez M, Leichtle A, Pak K, Ebmeyer J, Euteneuer S, Obonyo M, Guiney DG, Webster NJ, Broide DH, Ryan AF, Wasserman SI. PMID: 18986247.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    78. A catechol-O-methyltransferase that is essential for auditory function in mice and humans. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14609-14. Du X, Schwander M, Moresco EM, Viviani P, Haller C, Hildebrand MS, Pak K, Tarantino L, Roberts A, Richardson H, Koob G, Najmabadi H, Ryan AF, Smith RJ, Müller U, Beutler B. PMID: 18794526.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    79. Vestibular schwannoma quantitative polymerase chain reaction expression of estrogen and progesterone receptors. Laryngoscope. 2008 Aug; 118(8):1458-63. Patel AK, Alexander TH, Andalibi A, Ryan AF, Doherty JK. PMID: 18670322.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    80. Spiral ganglion outgrowth and hearing development in p75-deficient mice. Audiol Neurootol. 2008; 13(6):388-95. Brors D, Hansen S, Mlynski R, Volkenstein S, Aletsee C, Sendtner M, Ryan AF, Dazert S. PMID: 18663291.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    81. ErbB and Nrg: potential molecular targets for vestibular schwannoma pharmacotherapy. Otol Neurotol. 2008 Jan; 29(1):50-7. Doherty JK, Ongkeko W, Crawley B, Andalibi A, Ryan AF. PMID: 18199957.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    82. Laminin and fibronectin modulate inner ear spiral ganglion neurite outgrowth in an in vitro alternate choice assay. Dev Neurobiol. 2007 Nov; 67(13):1721-30. Evans AR, Euteneuer S, Chavez E, Mullen LM, Hui EE, Bhatia SN, Ryan AF. PMID: 17600813.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    83. Neuronal expression of peripherin, a type III intermediate filament protein, in the mouse hindbrain. Histochem Cell Biol. 2007 Dec; 128(6):541-50. Barclay M, Noakes PG, Ryan AF, Julien JP, Housley GD. PMID: 17899157.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    84. Hearing development and spiral ganglion neurite growth in VASP deficient mice. Brain Res. 2007 Oct 31; 1178:73-82. Dazert S, Schick B, Hartensuer R, Volkenstein S, Aletsee C, Hansen S, Shehata-Dieler WE, Eigenthaler M, Walter U, Ryan AF, Brors D. PMID: 17920567.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    85. N-glycolylneuraminic acid deficiency in mice: implications for human biology and evolution. Mol Cell Biol. 2007 Jun; 27(12):4340-6. Hedlund M, Tangvoranuntakul P, Takematsu H, Long JM, Housley GD, Kozutsumi Y, Suzuki A, Wynshaw-Boris A, Ryan AF, Gallo RL, Varki N, Varki A. PMID: 17420276.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    86. P2X receptor signaling inhibits BDNF-mediated spiral ganglion neuron development in the neonatal rat cochlea. Development. 2007 Apr; 134(7):1407-17. Greenwood D, Jagger DJ, Huang LC, Hoya N, Thorne PR, Wildman SS, King BF, Pak K, Ryan AF, Housley GD. PMID: 17329369.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    87. A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. J Neurosci. 2007 Feb 28; 27(9):2163-75. Schwander M, Sczaniecka A, Grillet N, Bailey JS, Avenarius M, Najmabadi H, Steffy BM, Federe GC, Lagler EA, Banan R, Hice R, Grabowski-Boase L, Keithley EM, Ryan AF, Housley GD, Wiltshire T, Smith RJ, Tarantino LM, Müller U. PMID: 17329413.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    88. Jun N-terminal protein kinase enhances middle ear mucosal proliferation during bacterial otitis media. Infect Immun. 2007 May; 75(5):2562-71. Furukawa M, Ebmeyer J, Pak K, Austin DA, Melhus A, Webster NJ, Ryan AF. PMID: 17325051.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    89. A PI3K pathway mediates hair cell survival and opposes gentamicin toxicity in neonatal rat organ of Corti. J Assoc Res Otolaryngol. 2006 Dec; 7(4):373-82. Chung WH, Pak K, Lin B, Webster N, Ryan AF. PMID: 17053865.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    90. Mouse models of induced otitis media. Brain Res. 2006 May 26; 1091(1):3-8. Ryan AF, Ebmeyer J, Furukawa M, Pak K, Melhus A, Wasserman SI, Chung WH. PMID: 16764829.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    91. Environmental micro-patterning for the study of spiral ganglion neurite guidance. Audiol Neurootol. 2006; 11(2):134-43. Ryan AF, Wittig J, Evans A, Dazert S, Mullen L. PMID: 16439836.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    92. Developmentally regulated expression of the P2X3 receptor in the mouse cochlea. Histochem Cell Biol. 2006 Jun; 125(6):681-92. Huang LC, Ryan AF, Cockayne DA, Housley GD. PMID: 16341871.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    93. Role of mast cells in otitis media. J Allergy Clin Immunol. 2005 Nov; 116(5):1129-35. Ebmeyer J, Furukawa M, Pak K, Ebmeyer U, Sudhoff H, Broide D, Ryan AF, Wasserman S. PMID: 16275387.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    94. The role of Fas-mediated apoptosis in otitis media: observations in the lpr/lpr mouse. Hear Res. 2005 Sep; 207(1-2):110-6. Rivkin AZ, Palacios SD, Pak K, Bennett T, Ryan AF. PMID: 15978756.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    95. Recent advances in otitis media. 4A. Molecular biology. Ann Otol Rhinol Laryngol Suppl. 2005 Jan; 194:42-9. Ryan AF, Jung TT, Juhn SK, Li JD, Andalibi A, Lin J, Bakaletz LO, Post CJ, Ehrlich GD. PMID: 15700934.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    96. Recent advances in otitis media. 4B. Biochemistry. Ann Otol Rhinol Laryngol Suppl. 2005 Jan; 194:50-5. Ryan AF, Jung TT, Juhn SK, Li JD, Andalibi A, Lin J, Bakaletz LO, Post CJ, Ehrlich GD. PMID: 15700935.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    97. Recent advances in otitis media. 4C. Interaction between middle ear and inner ear in otitis media. Ann Otol Rhinol Laryngol Suppl. 2005 Jan; 194:56-9. Ryan AF, Jung TT, Juhn SK, Li JD, Andalibi A, Lin J, Bakaletz LO, Post CJ, Ehrlich GD. PMID: 15700936.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    98. A reusable microfluidic plate with alternate-choice architecture for assessing growth preference in tissue culture. J Neurosci Methods. 2005 May 15; 144(1):79-89. Wittig JH, Ryan AF, Asbeck PM. PMID: 15848242.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    99. Role of p38 mitogen-activated protein kinase in middle ear mucosa hyperplasia during bacterial otitis media. Infect Immun. 2004 Aug; 72(8):4662-7. Palacios SD, Pak K, Rivkin AZ, Kayali AG, Austen D, Aletsee C, Melhus A, Webster NJ, Ryan AF. PMID: 15271927.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    100. Effects of amoxicillin on cytokine and osteocalcin expression in bone tissue during experimental acute otitis media. Cytokine. 2004 Mar 21; 25(6):254-9. Melhus A, Ryan AF. PMID: 15036240.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    101. Rapid muscle-specific gene expression changes after a single bout of eccentric contractions in the mouse. Am J Physiol Cell Physiol. 2004 Feb; 286(2):C355-64. Barash IA, Mathew L, Ryan AF, Chen J, Lieber RL. PMID: 14561590.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    102. A mouse model for acute otitis media. APMIS. 2003 Oct; 111(10):989-94. Melhus A, Ryan AF. PMID: 14616553.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    103. Fas ligand expression in the organ of Corti. Audiol Neurootol. 2003 Sep-Oct; 8(5):243-9. Bodmer D, Brors D, Bodmer M, Pak K, Ryan AF. PMID: 12904679.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    104. EphA4 provides repulsive signals to developing cochlear ganglion neurites mediated through ephrin-B2 and -B3. J Comp Neurol. 2003 Jul 14; 462(1):90-100. Brors D, Bodmer D, Pak K, Aletsee C, Schäfers M, Dazert S, Ryan AF. PMID: 12761826.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    105. Noise induces up-regulation of P2X2 receptor subunit of ATP-gated ion channels in the rat cochlea. Neuroreport. 2003 May 06; 14(6):817-23. Wang JC, Raybould NP, Luo L, Ryan AF, Cannell MB, Thorne PR, Housley GD. PMID: 12858039.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCellsPHPublic Health
    106. Branching of spiral ganglion neurites is induced by focal application of fibroblast growth factor-1. Laryngoscope. 2003 May; 113(5):791-6. Aletsee C, Brors D, Mlynski R, Ryan AF, Dazert S. PMID: 12792312.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    107. Gentamicin-induced hair cell death is not dependent on the apoptosis receptor Fas. Laryngoscope. 2003 Mar; 113(3):452-5. Bodmer D, Brors D, Pak K, Bodmer M, Ryan AF. PMID: 12616196.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    108. Contribution of BK Ca2+-activated K+ channels to auditory neurotransmission in the Guinea pig cochlea. J Neurophysiol. 2003 Jul; 90(1):320-32. Skinner LJ, Enée V, Beurg M, Jung HH, Ryan AF, Hafidi A, Aran JM, Dulon D. PMID: 12611976.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    109. Clostridium difficile toxin B, an inhibitor of the small GTPases Rho, Rac and Cdc42, influences spiral ganglion neurite outgrowth. Acta Otolaryngol. 2003 Jan; 123(1):20-5. Brors D, Aletsee C, Dazert S, Huverstuhl J, Ryan AF, Bodmer D. PMID: 12625568.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    110. The cell cycle and the development and regeneration of hair cells. Curr Top Dev Biol. 2003; 57:449-66. Ryan AF. PMID: 14674489.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    111. Participation of Ras and extracellular regulated kinase in the hyperplastic response of middle-ear mucosa during bacterial otitis media. J Infect Dis. 2002 Dec 15; 186(12):1761-9. Palacios SD, Pak K, Kayali AG, Rivkin AZ, Aletsee C, Melhus A, Webster NJ, Ryan AF. PMID: 12447762.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    112. Induction of MHC class II antigens on cells of the inner ear. Audiol Neurootol. 2002 Nov-Dec; 7(6):317-23. Gloddek B, Bodmer D, Brors D, Keithley EM, Ryan AF. PMID: 12463193.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    113. Inhibition of the c-Jun N-terminal kinase signaling pathway influences neurite outgrowth of spiral ganglion neurons in vitro. Laryngoscope. 2002 Nov; 112(11):2057-61. Bodmer D, Gloddek B, Ryan AF, Huverstuhl J, Brors D. PMID: 12439181.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    114. Rescue of auditory hair cells from aminoglycoside toxicity by Clostridium difficile toxin B, an inhibitor of the small GTPases Rho/Rac/Cdc42. Hear Res. 2002 Oct; 172(1-2):81-6. Bodmer D, Brors D, Pak K, Gloddek B, Ryan A. PMID: 12361869.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    115. Inflammatory signals increase Fas ligand expression by inner ear cells. J Neuroimmunol. 2002 Aug; 129(1-2):10-7. Bodmer D, Brors D, Pak K, Keithley EM, Mullen L, Ryan AF, Gloddek B. PMID: 12161015.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    116. Interaction of spiral ganglion neuron processes with alloplastic materials in vitro(1). Hear Res. 2002 May; 167(1-2):110-21. Brors D, Aletsee C, Schwager K, Mlynski R, Hansen S, Schäfers M, Ryan AF, Dazert S. PMID: 12117535.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    117. Molecular studies of hair cell development and survival. Audiol Neurootol. 2002 May-Jun; 7(3):138-40. Ryan AF. PMID: 12053133.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    118. Growth factors and their receptors in the middle ear mucosa during otitis media. Laryngoscope. 2002 Mar; 112(3):420-3. Palacios SD, Pak K, Rivkin AZ, Bennett T, Ryan AF. PMID: 12148846.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    119. The effects of laminin-1 on spiral ganglion neurons are dependent on the MEK/ERK signaling pathway and are partially independent of Ras. Hear Res. 2002 Feb; 164(1-2):1-11. Aletsee C, Brors D, Palacios S, Pak K, Mullen L, Dazert S, Ryan AF. PMID: 11950519.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    120. Immune-mediated hearing loss: basic mechanisms and options for therapy. Acta Otolaryngol Suppl. 2002; (548):38-43. Ryan AF, Harris JP, Keithley EM. PMID: 12211356.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    121. Immunological damage to the inner ear: current and future therapeutic strategies. Adv Otorhinolaryngol. 2002; 59:66-74. Ryan AF, Pak K, Low W, Battaglia A, Mullen L, Harris JP, Keithley EM. PMID: 11885663.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    122. Nitric oxide contributes to control of effusion in experimental otitis media. Laryngoscope. 2001 Feb; 111(2):301-5. Ryan AF, Bennett T. PMID: 11210879.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    123. Summary: progress in inner-ear immunology. Ann N Y Acad Sci. 1997 Dec 29; 830:326-9. Ryan AF. PMID: 9616693.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    124. Lymphocyte trafficking to the inner ear. Ann N Y Acad Sci. 1997 Dec 29; 830:236-42. Ryan AF, Gloddek B, Harris JP. PMID: 9616682.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
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