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Karl Wahlin

TitleAssistant Professor In Residence
InstitutionUniversity of California San Diego
DepartmentOphthalmology
Address9500 Gilman Drive #0946
La Jolla CA 92093
Phone858-822-7701
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    Collapse Biography 
    Collapse Education and Training
    Johns Hopkins School of Medicine, Baltimorepost-doc2015Ophthalmology
    Johns Hopkins School of Medicine, BaltimorePh.D.2009Neuroscience

    Collapse Overview 
    Collapse Overview
    My lab leverages stem cells and genetic engineering to uncover the basic biology of eye development. It is hoped that a better understanding of how the eye forms will give us new tools to combat debilitating eye diseases like glaucoma, retinitis pigments and age-related macular degeneration.


    Collapse Research 
    Collapse Research Activities and Funding
    Modeling Photoreceptor Development and Disease Using Human Pluripotent Stem Cells
    NIH/NEI R00EY024648Aug 1, 2016 - Jul 31, 2019
    Role: Principal Investigator
    Modeling Photoreceptor Development and Disease Using Human Pluripotent Stem Cells
    NIH/NEI K99EY024648Aug 1, 2014 - Jul 31, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Kauppila JH, Wahlin K, Lagergren P, Lagergren J. University hospital status and surgeon volume and risk of reoperation following surgery for esophageal cancer. Eur J Surg Oncol. 2018 May; 44(5):632-637. PMID: 29548804.
      View in: PubMed
    2. Tao W, Artama M, von Euler-Chelpin M, Konings P, Ljung R, Lynge E, Ólafsdóttir GH, Pukkala E, Romundstad P, Tryggvadottir L, Wahlin K, Lagergren J. Data Resource Profile: The Nordic Obesity Surgery Cohort (NordOSCo). Int J Epidemiol. 2018 Feb 01; 47(1):357. PMID: 29190345.
      View in: PubMed
    3. Kauppila JH, Wahlin K, Lagergren P, Lagergren J. Neoadjuvant therapy in relation to lymphadenectomy and resection margins during surgery for oesophageal cancer. Sci Rep. 2018 Jan 11; 8(1):446. PMID: 29323261.
      View in: PubMed
    4. Kauppila JH, Wahlin K, Lagergren J. Gastrectomy compared to oesophagectomy for Siewert II and III gastro-oesophageal junctional cancer in relation to resection margins, lymphadenectomy and survival. Sci Rep. 2017 Dec 19; 7(1):17783. PMID: 29259274.
      View in: PubMed
    5. Sverdén E, Brusselaers N, Wahlin K, Lagergren J. Time latencies of Helicobacter pylori eradication after peptic ulcer and risk of recurrent ulcer, ulcer adverse events, and gastric cancer: a population-based cohort study. Gastrointest Endosc. 2017 Dec 09. PMID: 29233672.
      View in: PubMed
    6. Brusselaers N, Wahlin K, Engstrand L, Lagergren J. Maintenance therapy with proton pump inhibitors and risk of gastric cancer: a nationwide population-based cohort study in Sweden. BMJ Open. 2017 Oct 30; 7(10):e017739. PMID: 29084798.
      View in: PubMed
    7. Remez LA, Onishi A, Menuchin-Lasowski Y, Biran A, Blackshaw S, Wahlin K, Zack DJ, Ashery-Padan R. Pax6 is essential for the generation of late-born retinal neurons and for inhibition of photoreceptor-fate during late stages of retinogenesis. Dev Biol. 2017 12 01; 432(1):140-150. PMID: 28993200.
      View in: PubMed
    8. Tao W, Artama M, von Euler-Chelpin M, Konings P, Ljung R, Lynge E, Ólafsdóttir GH, Pukkala E, Romundstad P, Tryggvadottir L, Wahlin K, Lagergren J. Data Resource Profile: The Nordic Obesity Surgery Cohort (NordOSCo). Int J Epidemiol. 2017 Oct 01; 46(5):1367-1367g. PMID: 29040667.
      View in: PubMed
    9. Maret-Ouda J, Wahlin K, El-Serag HB, Lagergren J. Association Between Laparoscopic Antireflux Surgery and Recurrence of Gastroesophageal Reflux. JAMA. 2017 09 12; 318(10):939-946. PMID: 28898377.
      View in: PubMed
    10. Vergara MN, Flores-Bellver M, Aparicio-Domingo S, McNally M, Wahlin K, Saxena MT, Mumm JS, Canto-Soler MV. Three-dimensional automated reporter quantification (3D-ARQ) technology enables quantitative screening in retinal organoids. Development. 2017 10 15; 144(20):3698-3705. PMID: 28870990.
      View in: PubMed
    11. Maret-Ouda J, Tao W, Wahlin K, Lagergren J. Nordic registry-based cohort studies: Possibilities and pitfalls when combining Nordic registry data. Scand J Public Health. 2017 Jul; 45(17_suppl):14-19. PMID: 28683665.
      View in: PubMed
    12. Maret-Ouda J, Wahlin K, Artama M, Brusselaers N, Färkkilä M, Lynge E, Mattsson F, Pukkala E, Romundstad P, Tryggvadóttir L, Euler-Chelpin MV, Lagergren J. Cohort profile: the Nordic Antireflux Surgery Cohort (NordASCo). BMJ Open. 2017 06 08; 7(6):e016505. PMID: 28600380.
      View in: PubMed
    13. Wilson DR, Routkevitch D, Rui Y, Mosenia A, Wahlin K, Quinones-Hinojosa A, Zack DJ, Green JJ. A Triple-Fluorophore-Labeled Nucleic Acid pH Nanosensor to Investigate Non-viral Gene Delivery. Mol Ther. 2017 Jul 05; 25(7):1697-1709. PMID: 28479046.
      View in: PubMed
    14. Wahlin K, Maruotti JA, Sripathi SR, Ball J, Angueyra JM, Kim C, Grebe R, Li W, Jones BW, Zack DJ. Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells. Sci Rep. 2017 04 10; 7(1):766. PMID: 28396597.
      View in: PubMed
    15. Xie SH, Wahlin K, Lagergren J. Cause of death in patients diagnosed with esophageal cancer in Sweden: a population-based study. Oncotarget. 2017 Aug 01; 8(31):51800-51809. PMID: 28881689.
      View in: PubMed
    16. Foster JW, Wahlin K, Adams SM, Birk DE, Zack DJ, Chakravarti S. Cornea organoids from human induced pluripotent stem cells. Sci Rep. 2017 Jan 27; 7:41286. PMID: 28128337.
      View in: PubMed
    17. Maruotti J, Sripathi SR, Bharti K, Fuller J, Wahlin K, Ranganathan V, Sluch VM, Berlinicke CA, Davis J, Kim C, Zhao L, Wan J, Qian J, Corneo B, Temple S, Dubey R, Olenyuk BZ, Bhutto I, Lutty GA, Zack DJ. Small-molecule-directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells. Proc Natl Acad Sci U S A. 2015 Sep 01; 112(35):10950-5. PMID: 26269569; PMCID: PMC4568212.
    18. Masuda T, Wahlin K, Wan J, Hu J, Maruotti J, Yang X, Iacovelli J, Wolkow N, Kist R, Dunaief JL, Qian J, Zack DJ, Esumi N. Transcription factor SOX9 plays a key role in the regulation of visual cycle gene expression in the retinal pigment epithelium. J Biol Chem. 2014 May 02; 289(18):12908-21. PMID: 24634209; PMCID: PMC4007478.
    19. Wahlin K, Maruotti J, Zack DJ. Modeling retinal dystrophies using patient-derived induced pluripotent stem cells. Adv Exp Med Biol. 2014; 801:157-64. PMID: 24664693; PMCID: PMC4117190.
    20. Bhise NS, Wahlin K, Zack DJ, Green JJ. Evaluating the potential of poly(beta-amino ester) nanoparticles for reprogramming human fibroblasts to become induced pluripotent stem cells. Int J Nanomedicine. 2013; 8:4641-58. PMID: 24348039; PMCID: PMC3857166.
    21. Wahlin K, Enke RA, Fuller JA, Kalesnykas G, Zack DJ, Merbs SL. Epigenetics and cell death: DNA hypermethylation in programmed retinal cell death. PLoS One. 2013; 8(11):e79140. PMID: 24244436; PMCID: PMC3823652.
    22. Zhang L, Wahlin K, Li Y, Masuda T, Yang Z, Zack DJ, Esumi N. RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors. Mol Vis. 2013; 19:1371-86. PMID: 23805044; PMCID: PMC3692409.
    23. Maruotti J, Wahlin K, Gorrell D, Bhutto I, Lutty G, Zack DJ. A simple and scalable process for the differentiation of retinal pigment epithelium from human pluripotent stem cells. Stem Cells Transl Med. 2013 May; 2(5):341-54. PMID: 23585288; PMCID: PMC3667560.
    24. Lumayag S, Haldin CE, Corbett NJ, Wahlin K, Cowan C, Turturro S, Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA, Xu S. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):E507-16. PMID: 23341629; PMCID: PMC3568372.
    25. Wahlin K, Hackler L, Adler R, Zack DJ. Alternative splicing of neuroligin and its protein distribution in the outer plexiform layer of the chicken retina. J Comp Neurol. 2010 Dec 15; 518(24):4938-62. PMID: 21031560; PMCID: PMC4065168.
    26. McNally MM, Wahlin K, Canto-Soler MV. Endogenous expression of ASLV viral proteins in specific pathogen free chicken embryos: relevance for the developmental biology research field. BMC Dev Biol. 2010 Oct 18; 10:106. PMID: 20955591; PMCID: PMC2973938.
    27. Engler C, Kelliher C, Wahlin K, Speck CL, Jun AS. Comparison of non-viral methods to genetically modify and enrich populations of primary human corneal endothelial cells. Mol Vis. 2009; 15:629-37. PMID: 19347048; PMCID: PMC2664841.
    28. Wahlin K, Moreira EF, Huang H, Yu N, Adler R. Molecular dynamics of photoreceptor synapse formation in the developing chick retina. J Comp Neurol. 2008 Feb 10; 506(5):822-37. PMID: 18076030.
      View in: PubMed
    29. Huang H, Wahlin K, McNally M, Irving ND, Adler R. Developmental regulation of muscleblind-like (MBNL) gene expression in the chicken embryo retina. Dev Dyn. 2008 Jan; 237(1):286-96. PMID: 18095352.
      View in: PubMed
    30. Pasterkamp RJ, Dai HN, Terman JR, Wahlin K, Kim B, Bregman BS, Popovich PG, Kolodkin AL. MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat. Mol Cell Neurosci. 2006 Jan; 31(1):52-69. PMID: 16230022.
      View in: PubMed
    31. Wahlin K, Lim L, Grice EA, Campochiaro PA, Zack DJ, Adler R. A method for analysis of gene expression in isolated mouse photoreceptor and Müller cells. Mol Vis. 2004 Jun 03; 10:366-75. PMID: 15205663.
      View in: PubMed
    32. Mori K, Gehlbach P, Ando A, Wahlin K, Gunther V, McVey D, Wei L, Campochiaro PA. Intraocular adenoviral vector-mediated gene transfer in proliferative retinopathies. Invest Ophthalmol Vis Sci. 2002 May; 43(5):1610-5. PMID: 11980881.
      View in: PubMed
    33. Wahlin K, Adler R, Zack DJ, Campochiaro PA. Neurotrophic signaling in normal and degenerating rodent retinas. Exp Eye Res. 2001 Nov; 73(5):693-701. PMID: 11747369.
      View in: PubMed
    34. Hackett SF, Ozaki H, Strauss RW, Wahlin K, Suri C, Maisonpierre P, Yancopoulos G, Campochiaro PA. Angiopoietin 2 expression in the retina: upregulation during physiologic and pathologic neovascularization. J Cell Physiol. 2000 Sep; 184(3):275-84. PMID: 10911358.
      View in: PubMed
    35. Wahlin K, Campochiaro PA, Zack DJ, Adler R. Neurotrophic factors cause activation of intracellular signaling pathways in Müller cells and other cells of the inner retina, but not photoreceptors. Invest Ophthalmol Vis Sci. 2000 Mar; 41(3):927-36. PMID: 10711715.
      View in: PubMed
    36. Mathura JR, Jafari N, Chang JT, Hackett SF, Wahlin K, Della NG, Okamoto N, Zack DJ, Campochiaro PA. Bone morphogenetic proteins-2 and -4: negative growth regulators in adult retinal pigmented epithelium. Invest Ophthalmol Vis Sci. 2000 Feb; 41(2):592-600. PMID: 10670493.
      View in: PubMed