Karl Wahlin
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Title(s) | Assistant Professor, Ophthalmology |
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School | Vc-health Sciences-schools |
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Address | 9500 Gilman Drive # La Jolla CA 92093
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vCard | Download vCard |
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Biography Johns Hopkins School of Medicine, Baltimore | post-doc | 2015 | Ophthalmology | Johns Hopkins School of Medicine, Baltimore | Ph.D. | 2009 | Neuroscience |
Bright focus Foundation | 2018 | | Carolyn K. McGillvray Award for Macular Degeneration | National Institute of Health (NIH) | 2015
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| 2019 | NIH Pathway to Independence Award (K99/R00) |
Overview My lab leverages stem cells and genetic engineering to uncover the basic biology of eye development. It is hoped that a better understanding of how the eye forms will give us new tools to combat debilitating eye diseases like glaucoma, retinitis pigments and age-related macular degeneration.
Research ORNG Applications Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
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Inhibition of GCK-IV kinases dissociates cell death and axon regeneration in CNS neurons. Proc Natl Acad Sci U S A. 2020 Dec 14.
Patel AK, Broyer RM, Lee CD, Lu T, Louie MJ, La Torre A, Al-Ali H, Vu MT, Mitchell KL, Wahlin KJ, Berlinicke CA, Jaskula-Ranga V, Hu Y, Duan X, Vilar S, Bixby JL, Weinreb RN, Lemmon VP, Zack DJ, Welsbie DS. PMID: 33318207.
View in: PubMed Mentions: Fields:
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Detection and validation of novel mutations in MERTK in a simplex case of retinal degeneration using WGS and hiPSC-RPEs model. Hum Mutat. 2020 Nov 30.
Biswas P, Borooah S, Matsui H, Voronchikhina M, Zhou J, Raghavendra PB, Riazuddin SA, Wahlin K, Frazer KA, Ayyagari R. PMID: 33252167.
View in: PubMed Mentions: Fields:
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Potential of Ocular Transmission of SARS-CoV-2: A Review. Vision (Basel). 2020 Sep 01; 4(3).
Barnett BP, Wahlin K, Krawczyk M, Spencer D, Welsbie D, Afshari N, Chao D. PMID: 32883010.
View in: PubMed Mentions:
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A Guide to the Development of Human CorneaOrganoids from Induced Pluripotent Stem Cells in Culture. Methods Mol Biol. 2020; 2145:51-58.
Foster JW, Wahlin KJ, Chakravarti S. PMID: 32542600.
View in: PubMed Mentions: Fields:
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Esophageal Adenocarcinoma After Antireflux Surgery in a Cohort Study From the 5 Nordic Countries. Ann Surg. 2019 Nov 27.
Maret-Ouda J, Santoni G, Wahlin K, Artama M, Brusselaers N, Färkkilä M, Lynge E, Mattsson F, Pukkala E, Romundstad P, Tryggvadóttir L, von Euler-Chelpin M, Lagergren J. PMID: 31800492.
View in: PubMed Mentions: Fields:
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Morphological and Molecular Defects in Human Three-Dimensional Retinal Organoid Model of X-Linked Juvenile Retinoschisis. Stem Cell Reports. 2019 11 12; 13(5):906-923.
Huang KC, Wang ML, Chen SJ, Kuo JC, Wang WJ, Nhi Nguyen PN, Wahlin KJ, Lu JF, Tran AA, Shi M, Chien Y, Yarmishyn AA, Tsai PH, Yang TC, Jane WN, Chang CC, Peng CH, Schlaeger TM, Chiou SH. PMID: 31668851.
View in: PubMed Mentions: 6 Fields: Translation: HumansCells
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Thyroid hormone signaling specifies cone subtypes in human retinal organoids. Science. 2018 10 12; 362(6411).
Eldred KC, Hadyniak SE, Hussey KA, Brenerman B, Zhang PW, Chamling X, Sluch VM, Welsbie DS, Hattar S, Taylor J, Wahlin K, Zack DJ, Johnston RJ. PMID: 30309916.
View in: PubMed Mentions: 28 Fields: Translation: HumansCells
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Pax6 is essential for the generation of late-born retinal neurons and for inhibition of photoreceptor-fate during late stages of retinogenesis. Dev Biol. 2017 12 01; 432(1):140-150.
Remez LA, Onishi A, Menuchin-Lasowski Y, Biran A, Blackshaw S, Wahlin KJ, Zack DJ, Ashery-Padan R. PMID: 28993200.
View in: PubMed Mentions: 9 Fields: Translation: AnimalsCells
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Three-dimensional automated reporter quantification (3D-ARQ) technology enables quantitative screening in retinal organoids. Development. 2017 10 15; 144(20):3698-3705.
Vergara MN, Flores-Bellver M, Aparicio-Domingo S, McNally M, Wahlin KJ, Saxena MT, Mumm JS, Canto-Soler MV. PMID: 28870990.
View in: PubMed Mentions: 12 Fields: Translation: HumansCells
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A Triple-Fluorophore-Labeled Nucleic Acid pH Nanosensor to Investigate Non-viral Gene Delivery. Mol Ther. 2017 07 05; 25(7):1697-1709.
Wilson DR, Routkevitch D, Rui Y, Mosenia A, Wahlin KJ, Quinones-Hinojosa A, Zack DJ, Green JJ. PMID: 28479046.
View in: PubMed Mentions: 7 Fields: Translation: HumansAnimals
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Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells. Sci Rep. 2017 04 10; 7(1):766.
Wahlin KJ, Maruotti JA, Sripathi SR, Ball J, Angueyra JM, Kim C, Grebe R, Li W, Jones BW, Zack DJ. PMID: 28396597.
View in: PubMed Mentions: 37 Fields: Translation: HumansCells
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Cornea organoids from human induced pluripotent stem cells. Sci Rep. 2017 01 27; 7:41286.
Foster JW, Wahlin K, Adams SM, Birk DE, Zack DJ, Chakravarti S. PMID: 28128337.
View in: PubMed Mentions: 15 Fields: Translation: HumansCells
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Small-molecule-directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells. Proc Natl Acad Sci U S A. 2015 Sep 01; 112(35):10950-5.
Maruotti J, Sripathi SR, Bharti K, Fuller J, Wahlin KJ, Ranganathan V, Sluch VM, Berlinicke CA, Davis J, Kim C, Zhao L, Wan J, Qian J, Corneo B, Temple S, Dubey R, Olenyuk BZ, Bhutto I, Lutty GA, Zack DJ. PMID: 26269569.
View in: PubMed Mentions: 27 Fields: Translation: HumansCells
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Transcription factor SOX9 plays a key role in the regulation of visual cycle gene expression in the retinal pigment epithelium. J Biol Chem. 2014 May 02; 289(18):12908-21.
Masuda T, Wahlin K, Wan J, Hu J, Maruotti J, Yang X, Iacovelli J, Wolkow N, Kist R, Dunaief JL, Qian J, Zack DJ, Esumi N. PMID: 24634209.
View in: PubMed Mentions: 16 Fields: Translation: HumansAnimalsCells
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Modeling retinal dystrophies using patient-derived induced pluripotent stem cells. Adv Exp Med Biol. 2014; 801:157-64.
Wahlin KJ, Maruotti J, Zack DJ. PMID: 24664693.
View in: PubMed Mentions: 9 Fields: Translation: HumansCells
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Evaluating the potential of poly(beta-amino ester) nanoparticles for reprogramming human fibroblasts to become induced pluripotent stem cells. Int J Nanomedicine. 2013; 8:4641-58.
Bhise NS, Wahlin KJ, Zack DJ, Green JJ. PMID: 24348039.
View in: PubMed Mentions: 9 Fields: Translation: HumansCells
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Epigenetics and cell death: DNA hypermethylation in programmed retinal cell death. PLoS One. 2013; 8(11):e79140.
Wahlin KJ, Enke RA, Fuller JA, Kalesnykas G, Zack DJ, Merbs SL. PMID: 24244436.
View in: PubMed Mentions: 7 Fields: Translation: HumansAnimalsCells
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RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors. Mol Vis. 2013; 19:1371-86.
Zhang L, Wahlin K, Li Y, Masuda T, Yang Z, Zack DJ, Esumi N. PMID: 23805044.
View in: PubMed Mentions: 8 Fields: Translation: HumansAnimalsCells
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A simple and scalable process for the differentiation of retinal pigment epithelium from human pluripotent stem cells. Stem Cells Transl Med. 2013 May; 2(5):341-54.
Maruotti J, Wahlin K, Gorrell D, Bhutto I, Lutty G, Zack DJ. PMID: 23585288.
View in: PubMed Mentions: 37 Fields: Translation: HumansAnimalsCells
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Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):E507-16.
Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S, Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA, Xu S. PMID: 23341629.
View in: PubMed Mentions: 74 Fields: Translation: AnimalsCells
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Alternative splicing of neuroligin and its protein distribution in the outer plexiform layer of the chicken retina. J Comp Neurol. 2010 Dec 15; 518(24):4938-62.
Wahlin KJ, Hackler L, Adler R, Zack DJ. PMID: 21031560.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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Endogenous expression of ASLV viral proteins in specific pathogen free chicken embryos: relevance for the developmental biology research field. BMC Dev Biol. 2010 Oct 18; 10:106.
McNally MM, Wahlin KJ, Canto-Soler MV. PMID: 20955591.
View in: PubMed Mentions: 7 Fields: Translation: AnimalsCells
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Comparison of non-viral methods to genetically modify and enrich populations of primary human corneal endothelial cells. Mol Vis. 2009; 15:629-37.
Engler C, Kelliher C, Wahlin KJ, Speck CL, Jun AS. PMID: 19347048.
View in: PubMed Mentions: 7 Fields: Translation: HumansCells
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Molecular dynamics of photoreceptor synapse formation in the developing chick retina. J Comp Neurol. 2008 Feb 10; 506(5):822-37.
Wahlin KJ, Moreira EF, Huang H, Yu N, Adler R. PMID: 18076030.
View in: PubMed Mentions: 18 Fields: Translation: AnimalsCells
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Developmental regulation of muscleblind-like (MBNL) gene expression in the chicken embryo retina. Dev Dyn. 2008 Jan; 237(1):286-96.
Huang H, Wahlin KJ, McNally M, Irving ND, Adler R. PMID: 18095352.
View in: PubMed Mentions: 7 Fields: Translation: AnimalsCells
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MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat. Mol Cell Neurosci. 2006 Jan; 31(1):52-69.
Pasterkamp RJ, Dai HN, Terman JR, Wahlin KJ, Kim B, Bregman BS, Popovich PG, Kolodkin AL. PMID: 16230022.
View in: PubMed Mentions: 24 Fields: Translation: HumansAnimals
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A method for analysis of gene expression in isolated mouse photoreceptor and Müller cells. Mol Vis. 2004 Jun 03; 10:366-75.
Wahlin KJ, Lim L, Grice EA, Campochiaro PA, Zack DJ, Adler R. PMID: 15205663.
View in: PubMed Mentions: 16 Fields: Translation: AnimalsCells
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Intraocular adenoviral vector-mediated gene transfer in proliferative retinopathies. Invest Ophthalmol Vis Sci. 2002 May; 43(5):1610-5.
Mori K, Gehlbach P, Ando A, Wahlin K, Gunther V, McVey D, Wei L, Campochiaro PA. PMID: 11980881.
View in: PubMed Mentions: 10 Fields: Translation: AnimalsCells
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Neurotrophic signaling in normal and degenerating rodent retinas. Exp Eye Res. 2001 Nov; 73(5):693-701.
Wahlin KJ, Adler R, Zack DJ, Campochiaro PA. PMID: 11747369.
View in: PubMed Mentions: 17 Fields: Translation: Animals
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Angiopoietin 2 expression in the retina: upregulation during physiologic and pathologic neovascularization. J Cell Physiol. 2000 Sep; 184(3):275-84.
Hackett SF, Ozaki H, Strauss RW, Wahlin K, Suri C, Maisonpierre P, Yancopoulos G, Campochiaro PA. PMID: 10911358.
View in: PubMed Mentions: 37 Fields: Translation: HumansAnimalsCells
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Neurotrophic factors cause activation of intracellular signaling pathways in Müller cells and other cells of the inner retina, but not photoreceptors. Invest Ophthalmol Vis Sci. 2000 Mar; 41(3):927-36.
Wahlin KJ, Campochiaro PA, Zack DJ, Adler R. PMID: 10711715.
View in: PubMed Mentions: 62 Fields: Translation: AnimalsCells
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Bone morphogenetic proteins-2 and -4: negative growth regulators in adult retinal pigmented epithelium. Invest Ophthalmol Vis Sci. 2000 Feb; 41(2):592-600.
Mathura JR, Jafari N, Chang JT, Hackett SF, Wahlin KJ, Della NG, Okamoto N, Zack DJ, Campochiaro PA. PMID: 10670493.
View in: PubMed Mentions: 26 Fields: Translation: HumansAnimalsCells
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Year | Publications |
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2000 | 3 | 2001 | 1 | 2002 | 1 | 2004 | 1 | 2005 | 1 | 2008 | 2 | 2009 | 1 | 2010 | 2 | 2013 | 5 | 2014 | 2 | 2015 | 1 | 2017 | 5 | 2018 | 1 | 2019 | 2 | 2020 | 4 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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