Karl Wahlin

TitleAssistant Professor In Residence
InstitutionUniversity of California San Diego
Address9500 Gilman Drive #0946
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Johns Hopkins School of Medicine, Baltimorepost-doc2015Ophthalmology
    Johns Hopkins School of Medicine, BaltimorePh.D.2009Neuroscience
    Collapse Awards and Honors
    Bright focus Foundation2018Carolyn K. McGillvray Award for Macular Degeneration
    National Institute of Health (NIH)2015  - 2019NIH Pathway to Independence Award (K99/R00)

    Collapse Overview 
    Collapse Overview
    My lab leverages stem cells and genetic engineering to uncover the basic biology of eye development. It is hoped that a better understanding of how the eye forms will give us new tools to combat debilitating eye diseases like glaucoma, retinitis pigments and age-related macular degeneration.

    Collapse Research 
    Collapse Research Activities and Funding
    Modeling Photoreceptor Development and Disease Using Human Pluripotent Stem Cells
    NIH/NEI R00EY024648Aug 1, 2016 - Jul 31, 2019
    Role: Principal Investigator
    Modeling Photoreceptor Development and Disease Using Human Pluripotent Stem Cells
    NIH/NEI K99EY024648Aug 1, 2014 - Jul 31, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Wang QL, Xie SH, Wahlin K, Lagergren J. Global time trends in the incidence of esophageal squamous cell carcinoma. Clin Epidemiol. 2018; 10:717-728. PMID: 29950901.
      View in: PubMed
    2. Remez LA, Onishi A, Menuchin-Lasowski Y, Biran A, Blackshaw S, Wahlin K, Zack DJ, Ashery-Padan R. Pax6 is essential for the generation of late-born retinal neurons and for inhibition of photoreceptor-fate during late stages of retinogenesis. Dev Biol. 2017 12 01; 432(1):140-150. PMID: 28993200.
      View in: PubMed
    3. Vergara MN, Flores-Bellver M, Aparicio-Domingo S, McNally M, Wahlin K, Saxena MT, Mumm JS, Canto-Soler MV. Three-dimensional automated reporter quantification (3D-ARQ) technology enables quantitative screening in retinal organoids. Development. 2017 10 15; 144(20):3698-3705. PMID: 28870990.
      View in: PubMed
    4. Wilson DR, Routkevitch D, Rui Y, Mosenia A, Wahlin K, Quinones-Hinojosa A, Zack DJ, Green JJ. A Triple-Fluorophore-Labeled Nucleic Acid pH Nanosensor to Investigate Non-viral Gene Delivery. Mol Ther. 2017 Jul 05; 25(7):1697-1709. PMID: 28479046.
      View in: PubMed
    5. Wahlin K, Maruotti JA, Sripathi SR, Ball J, Angueyra JM, Kim C, Grebe R, Li W, Jones BW, Zack DJ. Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells. Sci Rep. 2017 04 10; 7(1):766. PMID: 28396597.
      View in: PubMed
    6. Foster JW, Wahlin K, Adams SM, Birk DE, Zack DJ, Chakravarti S. Cornea organoids from human induced pluripotent stem cells. Sci Rep. 2017 Jan 27; 7:41286. PMID: 28128337.
      View in: PubMed
    7. Maruotti J, Sripathi SR, Bharti K, Fuller J, Wahlin K, Ranganathan V, Sluch VM, Berlinicke CA, Davis J, Kim C, Zhao L, Wan J, Qian J, Corneo B, Temple S, Dubey R, Olenyuk BZ, Bhutto I, Lutty GA, Zack DJ. Small-molecule-directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells. Proc Natl Acad Sci U S A. 2015 Sep 01; 112(35):10950-5. PMID: 26269569; PMCID: PMC4568212.
    8. Masuda T, Wahlin K, Wan J, Hu J, Maruotti J, Yang X, Iacovelli J, Wolkow N, Kist R, Dunaief JL, Qian J, Zack DJ, Esumi N. Transcription factor SOX9 plays a key role in the regulation of visual cycle gene expression in the retinal pigment epithelium. J Biol Chem. 2014 May 02; 289(18):12908-21. PMID: 24634209; PMCID: PMC4007478.
    9. Wahlin K, Maruotti J, Zack DJ. Modeling retinal dystrophies using patient-derived induced pluripotent stem cells. Adv Exp Med Biol. 2014; 801:157-64. PMID: 24664693; PMCID: PMC4117190.
    10. Bhise NS, Wahlin K, Zack DJ, Green JJ. Evaluating the potential of poly(beta-amino ester) nanoparticles for reprogramming human fibroblasts to become induced pluripotent stem cells. Int J Nanomedicine. 2013; 8:4641-58. PMID: 24348039; PMCID: PMC3857166.
    11. Wahlin K, Enke RA, Fuller JA, Kalesnykas G, Zack DJ, Merbs SL. Epigenetics and cell death: DNA hypermethylation in programmed retinal cell death. PLoS One. 2013; 8(11):e79140. PMID: 24244436; PMCID: PMC3823652.
    12. Zhang L, Wahlin K, Li Y, Masuda T, Yang Z, Zack DJ, Esumi N. RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors. Mol Vis. 2013; 19:1371-86. PMID: 23805044; PMCID: PMC3692409.
    13. Maruotti J, Wahlin K, Gorrell D, Bhutto I, Lutty G, Zack DJ. A simple and scalable process for the differentiation of retinal pigment epithelium from human pluripotent stem cells. Stem Cells Transl Med. 2013 May; 2(5):341-54. PMID: 23585288; PMCID: PMC3667560.
    14. Lumayag S, Haldin CE, Corbett NJ, Wahlin K, Cowan C, Turturro S, Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA, Xu S. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):E507-16. PMID: 23341629; PMCID: PMC3568372.
    15. Wahlin K, Hackler L, Adler R, Zack DJ. Alternative splicing of neuroligin and its protein distribution in the outer plexiform layer of the chicken retina. J Comp Neurol. 2010 Dec 15; 518(24):4938-62. PMID: 21031560; PMCID: PMC4065168.
    16. McNally MM, Wahlin K, Canto-Soler MV. Endogenous expression of ASLV viral proteins in specific pathogen free chicken embryos: relevance for the developmental biology research field. BMC Dev Biol. 2010 Oct 18; 10:106. PMID: 20955591; PMCID: PMC2973938.
    17. Engler C, Kelliher C, Wahlin K, Speck CL, Jun AS. Comparison of non-viral methods to genetically modify and enrich populations of primary human corneal endothelial cells. Mol Vis. 2009; 15:629-37. PMID: 19347048; PMCID: PMC2664841.
    18. Wahlin K, Moreira EF, Huang H, Yu N, Adler R. Molecular dynamics of photoreceptor synapse formation in the developing chick retina. J Comp Neurol. 2008 Feb 10; 506(5):822-37. PMID: 18076030.
      View in: PubMed
    19. Huang H, Wahlin K, McNally M, Irving ND, Adler R. Developmental regulation of muscleblind-like (MBNL) gene expression in the chicken embryo retina. Dev Dyn. 2008 Jan; 237(1):286-96. PMID: 18095352.
      View in: PubMed
    20. Pasterkamp RJ, Dai HN, Terman JR, Wahlin K, Kim B, Bregman BS, Popovich PG, Kolodkin AL. MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat. Mol Cell Neurosci. 2006 Jan; 31(1):52-69. PMID: 16230022.
      View in: PubMed
    21. Wahlin K, Lim L, Grice EA, Campochiaro PA, Zack DJ, Adler R. A method for analysis of gene expression in isolated mouse photoreceptor and Müller cells. Mol Vis. 2004 Jun 03; 10:366-75. PMID: 15205663.
      View in: PubMed
    22. Mori K, Gehlbach P, Ando A, Wahlin K, Gunther V, McVey D, Wei L, Campochiaro PA. Intraocular adenoviral vector-mediated gene transfer in proliferative retinopathies. Invest Ophthalmol Vis Sci. 2002 May; 43(5):1610-5. PMID: 11980881.
      View in: PubMed
    23. Wahlin K, Adler R, Zack DJ, Campochiaro PA. Neurotrophic signaling in normal and degenerating rodent retinas. Exp Eye Res. 2001 Nov; 73(5):693-701. PMID: 11747369.
      View in: PubMed