Karl Wahlin

Title(s)Assistant Professor, Ophthalmology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Johns Hopkins School of Medicine, Baltimorepost-doc2015Ophthalmology
    Johns Hopkins School of Medicine, BaltimorePh.D.2009Neuroscience
    Collapse Awards and Honors
    Bright focus Foundation2018Carolyn K. McGillvray Award for Macular Degeneration
    National Institute of Health (NIH)2015  - 2019NIH Pathway to Independence Award (K99/R00)

    Collapse Overview 
    Collapse Overview
    My lab leverages stem cells and genetic engineering to uncover the basic biology of eye development. It is hoped that a better understanding of how the eye forms will give us new tools to combat debilitating eye diseases like glaucoma, retinitis pigments and age-related macular degeneration.

    Collapse Research 
    Collapse Research Activities and Funding
    Pluripotent Stem Cell Derived 3D Retinas for Studies of Early Onset Retinal Degeneration
    NIH R01EY031318Apr 1, 2020 - Mar 31, 2025
    Role: Principal Investigator
    A stem cell based optic nerve model for studies of axon guidance and regeneration
    NIH R21EY031122Aug 1, 2019 - Jul 31, 2020
    Role: Principal Investigator
    Modeling Photoreceptor Development and Disease Using Human Pluripotent Stem Cells
    NIH R00EY024648Aug 1, 2016 - Jul 31, 2020
    Role: Principal Investigator
    Modeling Photoreceptor Development and Disease Using Human Pluripotent Stem Cells
    NIH K99EY024648Aug 1, 2014 - Jul 31, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Temporal and Isoform-Specific Expression of CTBP2 Is Evolutionarily Conserved Between the Developing Chick and Human Retina. Front Mol Neurosci. 2021; 14:773356. Gage E, Agarwal D, Chenault C, Washington-Brown K, Szvetecz S, Jahan N, Wang Z, Jones MK, Zack DJ, Enke RA, Wahlin KJ. PMID: 35095414; PMCID: PMC8793361.
      View in: PubMed   Mentions:
    2. Esophageal Adenocarcinoma After Antireflux Surgery in a Cohort Study From the 5 Nordic Countries. Ann Surg. 2021 12 01; 274(6):e535-e540. Maret-Ouda J, Santoni G, Wahlin K, Artama M, Brusselaers N, Färkkilä M, Lynge E, Mattsson F, Pukkala E, Romundstad P, Tryggvadóttir L, von Euler-Chelpin M, Lagergren J. PMID: 31800492.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. CRISPR Generated SIX6 and POU4F2 Reporters Allow Identification of Brain and Optic Transcriptional Differences in Human PSC-Derived Organoids. Front Cell Dev Biol. 2021; 9:764725. Wahlin KJ, Cheng J, Jurlina SL, Jones MK, Dash NR, Ogata A, Kibria N, Ray S, Eldred KC, Kim C, Heng JS, Phillips J, Johnston RJ, Gamm DM, Berlinicke C, Zack DJ. PMID: 34869356; PMCID: PMC8635054.
      View in: PubMed   Mentions: 2  
    4. Proteome Landscape of Epithelial-to-Mesenchymal Transition (EMT) of Retinal Pigment Epithelium Shares Commonalities With Malignancy-Associated EMT. Mol Cell Proteomics. 2021; 20:100131. Sripathi SR, Hu MW, Turaga RC, Mertz J, Liu MM, Wan J, Maruotti J, Wahlin KJ, Berlinicke CA, Qian J, Zack DJ. PMID: 34455105; PMCID: PMC8482521.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    5. Transcriptome Landscape of Epithelial to Mesenchymal Transition of Human Stem Cell-Derived RPE. Invest Ophthalmol Vis Sci. 2021 04 01; 62(4):1. Sripathi SR, Hu MW, Liu MM, Wan J, Cheng J, Duan Y, Mertz JL, Wahlin KJ, Maruotti J, Berlinicke CA, Qian J, Zack DJ. PMID: 33792620; PMCID: PMC8024778.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Inhibition of GCK-IV kinases dissociates cell death and axon regeneration in CNS neurons. Proc Natl Acad Sci U S A. 2020 12 29; 117(52):33597-33607. Patel AK, Broyer RM, Lee CD, Lu T, Louie MJ, La Torre A, Al-Ali H, Vu MT, Mitchell KL, Wahlin KJ, Berlinicke CA, Jaskula-Ranga V, Hu Y, Duan X, Vilar S, Bixby JL, Weinreb RN, Lemmon VP, Zack DJ, Welsbie DS. PMID: 33318207; PMCID: PMC7777023.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    7. Detection and validation of novel mutations in MERTK in a simplex case of retinal degeneration using WGS and hiPSC-RPEs model. Hum Mutat. 2021 02; 42(2):189-199. Biswas P, Borooah S, Matsui H, Voronchikhina M, Zhou J, Zawaydeh Q, Raghavendra PB, Ferreyra H, Riazuddin SA, Wahlin K, Frazer KA, Ayyagari R. PMID: 33252167; PMCID: PMC7878419.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. Potential of Ocular Transmission of SARS-CoV-2: A Review. Vision (Basel). 2020 Sep 01; 4(3). Barnett BP, Wahlin K, Krawczyk M, Spencer D, Welsbie D, Afshari N, Chao D. PMID: 32883010; PMCID: PMC7559808.
      View in: PubMed   Mentions: 17  
    9. A Guide to the Development of Human CorneaOrganoids from Induced Pluripotent Stem Cells in Culture. Methods Mol Biol. 2020; 2145:51-58. Foster JW, Wahlin KJ, Chakravarti S. PMID: 32542600; PMCID: PMC7565088.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. Morphological and Molecular Defects in Human Three-Dimensional Retinal Organoid Model of X-Linked Juvenile Retinoschisis. Stem Cell Reports. 2019 11 12; 13(5):906-923. Huang KC, Wang ML, Chen SJ, Kuo JC, Wang WJ, Nhi Nguyen PN, Wahlin KJ, Lu JF, Tran AA, Shi M, Chien Y, Yarmishyn AA, Tsai PH, Yang TC, Jane WN, Chang CC, Peng CH, Schlaeger TM, Chiou SH. PMID: 31668851; PMCID: PMC6895767.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    11. A combinatorial library of biodegradable polyesters enables non-viral gene delivery to post-mitotic human stem cell-derived polarized RPE monolayers. Regen Eng Transl Med. 2019 Sep; 6(3):273-285. Mishra B, Wilson DR, Sripathi SR, Suprenant MP, Rui Y, Wahlin KJ, Berlinicke CA, Green JJ, Zack DJ. PMID: 33732871; PMCID: PMC7962803.
      View in: PubMed   Mentions: 3  
    12. Thyroid hormone signaling specifies cone subtypes in human retinal organoids. Science. 2018 10 12; 362(6411). Eldred KC, Hadyniak SE, Hussey KA, Brenerman B, Zhang PW, Chamling X, Sluch VM, Welsbie DS, Hattar S, Taylor J, Wahlin K, Zack DJ, Johnston RJ. PMID: 30309916; PMCID: PMC6249681.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    13. Pax6 is essential for the generation of late-born retinal neurons and for inhibition of photoreceptor-fate during late stages of retinogenesis. Dev Biol. 2017 12 01; 432(1):140-150. Remez LA, Onishi A, Menuchin-Lasowski Y, Biran A, Blackshaw S, Wahlin KJ, Zack DJ, Ashery-Padan R. PMID: 28993200; PMCID: PMC5882491.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    14. Three-dimensional automated reporter quantification (3D-ARQ) technology enables quantitative screening in retinal organoids. Development. 2017 10 15; 144(20):3698-3705. Vergara MN, Flores-Bellver M, Aparicio-Domingo S, McNally M, Wahlin KJ, Saxena MT, Mumm JS, Canto-Soler MV. PMID: 28870990; PMCID: PMC5675442.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    15. A Triple-Fluorophore-Labeled Nucleic Acid pH Nanosensor to Investigate Non-viral Gene Delivery. Mol Ther. 2017 07 05; 25(7):1697-1709. Wilson DR, Routkevitch D, Rui Y, Mosenia A, Wahlin KJ, Quinones-Hinojosa A, Zack DJ, Green JJ. PMID: 28479046; PMCID: PMC5498830.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    16. Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells. Sci Rep. 2017 04 10; 7(1):766. Wahlin KJ, Maruotti JA, Sripathi SR, Ball J, Angueyra JM, Kim C, Grebe R, Li W, Jones BW, Zack DJ. PMID: 28396597; PMCID: PMC5429674.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells
    17. Cornea organoids from human induced pluripotent stem cells. Sci Rep. 2017 01 27; 7:41286. Foster JW, Wahlin K, Adams SM, Birk DE, Zack DJ, Chakravarti S. PMID: 28128337; PMCID: PMC5269590.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    18. Small-molecule-directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells. Proc Natl Acad Sci U S A. 2015 Sep 01; 112(35):10950-5. Maruotti J, Sripathi SR, Bharti K, Fuller J, Wahlin KJ, Ranganathan V, Sluch VM, Berlinicke CA, Davis J, Kim C, Zhao L, Wan J, Qian J, Corneo B, Temple S, Dubey R, Olenyuk BZ, Bhutto I, Lutty GA, Zack DJ. PMID: 26269569; PMCID: PMC4568212.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    19. Transcription factor SOX9 plays a key role in the regulation of visual cycle gene expression in the retinal pigment epithelium. J Biol Chem. 2014 May 02; 289(18):12908-21. Masuda T, Wahlin K, Wan J, Hu J, Maruotti J, Yang X, Iacovelli J, Wolkow N, Kist R, Dunaief JL, Qian J, Zack DJ, Esumi N. PMID: 24634209; PMCID: PMC4007478.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    20. Modeling retinal dystrophies using patient-derived induced pluripotent stem cells. Adv Exp Med Biol. 2014; 801:157-64. Wahlin KJ, Maruotti J, Zack DJ. PMID: 24664693; PMCID: PMC4117190.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    21. Evaluating the potential of poly(beta-amino ester) nanoparticles for reprogramming human fibroblasts to become induced pluripotent stem cells. Int J Nanomedicine. 2013; 8:4641-58. Bhise NS, Wahlin KJ, Zack DJ, Green JJ. PMID: 24348039; PMCID: PMC3857166.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    22. Epigenetics and cell death: DNA hypermethylation in programmed retinal cell death. PLoS One. 2013; 8(11):e79140. Wahlin KJ, Enke RA, Fuller JA, Kalesnykas G, Zack DJ, Merbs SL. PMID: 24244436; PMCID: PMC3823652.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    23. RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors. Mol Vis. 2013; 19:1371-86. Zhang L, Wahlin K, Li Y, Masuda T, Yang Z, Zack DJ, Esumi N. PMID: 23805044; PMCID: PMC3692409.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    24. A simple and scalable process for the differentiation of retinal pigment epithelium from human pluripotent stem cells. Stem Cells Transl Med. 2013 May; 2(5):341-54. Maruotti J, Wahlin K, Gorrell D, Bhutto I, Lutty G, Zack DJ. PMID: 23585288; PMCID: PMC3667560.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    25. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):E507-16. Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S, Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA, Xu S. PMID: 23341629; PMCID: PMC3568372.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    26. Alternative splicing of neuroligin and its protein distribution in the outer plexiform layer of the chicken retina. J Comp Neurol. 2010 Dec 15; 518(24):4938-62. Wahlin KJ, Hackler L, Adler R, Zack DJ. PMID: 21031560; PMCID: PMC4065168.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    27. Endogenous expression of ASLV viral proteins in specific pathogen free chicken embryos: relevance for the developmental biology research field. BMC Dev Biol. 2010 Oct 18; 10:106. McNally MM, Wahlin KJ, Canto-Soler MV. PMID: 20955591; PMCID: PMC2973938.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    28. Comparison of non-viral methods to genetically modify and enrich populations of primary human corneal endothelial cells. Mol Vis. 2009; 15:629-37. Engler C, Kelliher C, Wahlin KJ, Speck CL, Jun AS. PMID: 19347048; PMCID: PMC2664841.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    29. Molecular dynamics of photoreceptor synapse formation in the developing chick retina. J Comp Neurol. 2008 Feb 10; 506(5):822-37. Wahlin KJ, Moreira EF, Huang H, Yu N, Adler R. PMID: 18076030.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    30. Developmental regulation of muscleblind-like (MBNL) gene expression in the chicken embryo retina. Dev Dyn. 2008 Jan; 237(1):286-96. Huang H, Wahlin KJ, McNally M, Irving ND, Adler R. PMID: 18095352.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    31. MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat. Mol Cell Neurosci. 2006 Jan; 31(1):52-69. Pasterkamp RJ, Dai HN, Terman JR, Wahlin KJ, Kim B, Bregman BS, Popovich PG, Kolodkin AL. PMID: 16230022.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    32. A method for analysis of gene expression in isolated mouse photoreceptor and Müller cells. Mol Vis. 2004 Jun 03; 10:366-75. Wahlin KJ, Lim L, Grice EA, Campochiaro PA, Zack DJ, Adler R. PMID: 15205663.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    33. Intraocular adenoviral vector-mediated gene transfer in proliferative retinopathies. Invest Ophthalmol Vis Sci. 2002 May; 43(5):1610-5. Mori K, Gehlbach P, Ando A, Wahlin K, Gunther V, McVey D, Wei L, Campochiaro PA. PMID: 11980881.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    34. Neurotrophic signaling in normal and degenerating rodent retinas. Exp Eye Res. 2001 Nov; 73(5):693-701. Wahlin KJ, Adler R, Zack DJ, Campochiaro PA. PMID: 11747369.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    35. Angiopoietin 2 expression in the retina: upregulation during physiologic and pathologic neovascularization. J Cell Physiol. 2000 Sep; 184(3):275-84. Hackett SF, Ozaki H, Strauss RW, Wahlin K, Suri C, Maisonpierre P, Yancopoulos G, Campochiaro PA. PMID: 10911358.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    36. Neurotrophic factors cause activation of intracellular signaling pathways in Müller cells and other cells of the inner retina, but not photoreceptors. Invest Ophthalmol Vis Sci. 2000 Mar; 41(3):927-36. Wahlin KJ, Campochiaro PA, Zack DJ, Adler R. PMID: 10711715.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    37. Bone morphogenetic proteins-2 and -4: negative growth regulators in adult retinal pigmented epithelium. Invest Ophthalmol Vis Sci. 2000 Feb; 41(2):592-600. Mathura JR, Jafari N, Chang JT, Hackett SF, Wahlin KJ, Della NG, Okamoto N, Zack DJ, Campochiaro PA. PMID: 10670493.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
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