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Christina Jamieson

Address	9500 Gilman Drive #0658 CA La Jolla 92093
Phone	858-534-2921
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Overview

Dr. Jamieson's research is focused on elucidating mechanisms of therapy resistance in bone metastatic urologic cancers using patient-derived xenograft (PDX) models and 3D in vitro models. She is applying her expertise in genome-wide analyses of prostate cancer tumors and primary patient-derived tumor models to translate next generation genomics on prostate cancers into practical applications and novel therapies that will improve and, she hopes, eventually transform patient care.

Research Overview
Dr. Jamieson's research is focused on elucidating mechanisms of therapy resistance in bone metastatic urologic cancers using patient-derived xenograft (PDX) models and 3D in vitro models. She is applying her expertise in genome-wide analyses of prostate cancer tumors and primary patient-derived tumor models to translate next generation genomics on prostate cancers into practical applications and novel therapies that will improve and, she hopes, eventually transform patient care.

Research Topics
- Cancer
- Cell Biology
- Endocrinology
- Genomics
- Immunology
- Molecular Biology
- Regeneration/Stem Cells
- Translational Research

Current Project Titles
- Novel patient-derived xenograft models of bone metastatic prostate cancer.
- Genomic profiling of castration-resistant prostate cancer in the bone-niche.

ORNG Applications

Websites

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.

List All | Timeline

Shalapour S, Font-Burgada J, Di Caro G, Zhong Z, Sanchez-Lopez E, Dhar D, Willimsky G, Ammirante M, Strasner A, Hansel DE, Jamieson C, Kane CJ, Klatte T, Birner P, Kenner L, Karin M. Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy. Nature. 2015 May 7; 521(7550):94-8. PMID: 25924065.

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Godebu E, Muldong M, Strasner A, Wu C, Park S, Woo JR, Ma W, Liss MA, Hirata T, Raheem O, Cacalano NA, Kulidjian AA, Jamieson C. PCSD1, a new patient-derived model of bone metastatic prostate cancer, is castrate-resistant in the bone-niche. J Transl Med. 2014 Oct 3; 12(1):275. PMID: 25278011.

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Ammirante M, Shalapour S, Kang Y, Jamieson C, Karin M. Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14776-81. PMID: 25267627.

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Woo JR, Liss MA, Muldong MT, Palazzi K, Strasner A, Ammirante M, Varki N, Shabaik A, Howell S, Kane CJ, Karin M, Jamieson C. Tumor infiltrating B-cells are increased in prostate cancer tissue. J Transl Med. 2014; 12(1):30. PMID: 24475900.

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Goff DJ, Recart AC, Sadarangani A, Chun HJ, Barrett CL, Krajewska M, Leu H, Low-Marchelli J, Ma W, Shih AY, Wei J, Zhai D, Geron I, Pu M, Bao L, Chuang R, Balaian L, Gotlib J, Minden M, Martinelli G, Rusert J, Dao KH, Shazand K, Wentworth P, Smith KM, Jamieson CA, Morris SR, Messer K, Goldstein LS, Hudson TJ, Marra M, Frazer KA, Pellecchia M, Reed JC, Jamieson C. A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. Cell Stem Cell. 2013 Mar 7; 12(3):316-28. PMID: 23333150.

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Ma W, Gutierrez A, Goff DJ, Geron I, Sadarangani A, Jamieson CA, Court AC, Shih AY, Jiang Q, Wu CC, Li K, Smith KM, Crews LA, Gibson NW, Deichaite I, Morris SR, Wei P, Carson DA, Look AT, Jamieson C. NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. PLoS One. 2012; 7(6):e39725. PMID: 22768113.

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Raheem O, Kulidjian AA, Wu C, Jeong YB, Yamaguchi T, Smith KM, Goff D, Leu H, Morris SR, Cacalano NA, Masuda K, Jamieson CH, Kane CJ, Jamieson C. A novel patient-derived intra-femoral xenograft model of bone metastatic prostate cancer that recapitulates mixed osteolytic and osteoblastic lesions. J Transl Med. 2011; 9:185. PMID: 22035283.

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Belanto JJ, Diaz-Perez SV, Magyar CE, Maxwell MM, Yilmaz Y, Topp K, Boso G, Jamieson CH, Cacalano NA, Jamieson C. Dexamethasone induces dysferlin in myoblasts and enhances their myogenic differentiation. Neuromuscul Disord. 2010 Feb; 20(2):111-21. PMID: 20080405.

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Peng L, Wu TT, Tchieu JH, Feng J, Brown HJ, Feng J, Li X, Qi J, Deng H, Vivanco I, Mellinghoff IK, Jamieson C, Sun R. Inhibition of the phosphatidylinositol 3-kinase-Akt pathway enhances gamma-2 herpesvirus lytic replication and facilitates reactivation from latency. J Gen Virol. 2010 Feb; 91(Pt 2):463-9. PMID: 19864499.

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Sitko JC, Yeh B, Kim M, Zhou H, Takaesu G, Yoshimura A, McBride WH, Jewett A, Jamieson C, Cacalano NA. SOCS3 regulates p21 expression and cell cycle arrest in response to DNA damage. Cell Signal. 2008 Dec; 20(12):2221-30. PMID: 18793717.

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Zhou H, Miki R, Eeva M, Fike FM, Seligson D, Yang L, Yoshimura A, Teitell MA, Jamieson C, Cacalano NA. Reciprocal regulation of SOCS 1 and SOCS3 enhances resistance to ionizing radiation in glioblastoma multiforme. Clin Cancer Res. 2007 Apr 15; 13(8):2344-53. PMID: 17438093.

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Poon MM, Choi SH, Jamieson C, Geschwind DH, Martin KC. Identification of process-localized mRNAs from cultured rodent hippocampal neurons. J Neurosci. 2006 Dec 20; 26(51):13390-9. PMID: 17182790.

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Jamieson C, Yamamoto KR. Crosstalk pathway for inhibition of glucocorticoid-induced apoptosis by T cell receptor signaling. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7319-24. PMID: 10860997.

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