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Michael Mccarthy

Title(s)Associate Adjunct Professor, Psychiatry
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Biography

    Dr. McCarthy earned a B.S. in Biochemistry and Psychology from the University of New Mexico, before completing his doctoral training in medicine and neuroscience at Ohio State University. Dr. McCarthy developed an interest in Bipolar Disorder during his psychiatry residency at UCSD (2005-2009), and subsequently completed a post-doctoral research fellowship in the molecular biology of mood disorders and chronobiology at UCSD. Dr McCarthy joined the UCSD faculty in 2011. He is presently sees patients in the VA San Diego mood-sleep clinic, is the principle investigator on funded basic and clinical research projects in Bipolar Disorder. He is the field editor for neurobiology for Acta Psychiatrica Scandinavica, and a member of the UCSD Clinical Translation Research Institute (CTRI), and Center for Circadian Biology (CCB).

    Research Interests

    Due to regular intervals of light and dark caused by the Earth’s rotation around the sun, circadian clock genes have been selected through evolution to assist living organisms (including humans) in dealing with changes in temperature, food availability and social interaction. These genes have been shown to govern not only sleep wake behaviors, but also the brain’s reward and motivation systems. For these reasons, clock genes have been implicated in mood disorders such as bipolar disorder and major depression, and also substances abuse disorders like alcoholism. Clinically, the potential for clock gene influence is reinforced by features of these illnesses in which the commonly encountered alterations in sleep wake cycles, appetite, and other rhythmic behaviors are responsive to light availability and/or season. Similarly, lithium, a medication for treating mood disorders, has effects on rhythmic daily behaviors and affects the expression of several clock genes.

    In the laboratory, we are using cell lines and DNA from psychiatric patients to examine circadian clock genes. We measure clock gene expression using bioluminescent reporter assays to determine if their rhythms are disturbed relative to cells from unaffected subjects, or if the expression rhythms respond differentially to conditions like lithium treatment or stress. We also examine genetic variants in candidate clock genes to determine if these are associated with clinical features of mood disorders such as lithium response. Where possible, we link associated genetic variants to functional differences in gene regulation.

    Clinical Focus

    I treat veterans suffering from disturbances in mood where bipolar disorder is considered as likely in the differential diagnosis. Therefore, many of my patients have bipolar disorder, but others may be diagnosed with major depression, personality disorders or psychotic disorders like schizophrenia. Many patients have multiple diagnoses, including post-traumatic stress disorder and substance use disorders. In some cases, I use pharmacogenetic tools or collect genetic samples in hopes of establishing biological predictors of medication response in the future.

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    Circadian rhythms and cell survival in lithium responsive bipolar disorder.
    VA I01BX003431Apr 1, 2017 - Mar 31, 2021
    Role: Principal Investigator
    Circadian Clock Genes in Bipolar Disorder
    VA IK2BX001275Oct 1, 2011 - Sep 30, 2016
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sleep and Circadian Rhythm Disruption Is Corrected by Lithium in a Case of Bipolar Disorder with Familial BRCA1 Mutation. Bipolar Disord. 2020 Oct 04. Federoff M, McCarthy MJ. PMID: 33012081.
      View in: PubMed   Mentions:    Fields:    
    2. Attitudes on pharmacogenetic testing in psychiatric patients with treatment-resistant depression. Depress Anxiety. 2020 Sep; 37(9):842-850. McCarthy MJ, Chen Y, Demodena A, Fisher E, Golshan S, Suppes T, Kelsoe JR. PMID: 32667102.
      View in: PubMed   Mentions:    Fields:    
    3. The association between lithium use and neurocognitive performance in patients with bipolar disorder. Neuropsychopharmacology. 2020 09; 45(10):1743-1749. Burdick KE, Millett CE, Russo M, Alda M, Alliey-Rodriguez N, Anand A, Balaraman Y, Berrettini W, Bertram H, Calabrese JR, Calkin C, Conroy C, Coryell W, DeModena A, Feeder S, Fisher C, Frazier N, Frye M, Gao K, Garnham J, Gershon ES, Glazer K, Goes FS, Goto T, Harrington GJ, Jakobsen P, Kamali M, Kelly M, Leckband S, Løberg EM, Lohoff FW, Maihofer AX, McCarthy MJ, McInnis M, Morken G, Nievergelt CM, Nurnberger J, Oedegaard KJ, Ortiz A, Ritchey M, Ryan K, Schinagle M, Schwebel C, Shaw M, Shilling P, Slaney C, Stapp E, Tarwater B, Zandi P, Kelsoe JR. PMID: 32349118.
      View in: PubMed   Mentions:    Fields:    
    4. Association of polygenic score for major depression with response to lithium in patients with bipolar disorder. Mol Psychiatry. 2020 Mar 16. Amare AT, Schubert KO, Hou L, Clark SR, Papiol S, Cearns M, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hsu YH, Shekhtman T, Adli M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, Bengesser S, Biernacka JM, Birner A, Brichant-Petitjean C, Cervantes P, Chen HC, Chillotti C, Cichon S, Cruceanu C, Czerski PM, Dalkner N, Dayer A, Del Zompo M, DePaulo JR, Étain B, Jamain S, Falkai P, Forstner AJ, Frisen L, Frye MA, Fullerton JM, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jiménez E, Kahn JP, Kassem L, Kuo PH, Kato T, Kelsoe JR, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Tortorella A, Manchia M, Martinsson L, McCarthy MJ, McElroy SL, Colom F, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Novák T, O'Donovan C, Ozaki N, Ösby U, Pfennig A, Potash JB, Reif A, Reininghaus E, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schweizer BW, Severino G, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Maj M, Turecki G, Vieta E, Veeh J, Witt SH, Wright A, Zandi PP, Mitchell PB, Bauer M, Alda M, Rietschel M, McMahon FJ, Schulze TG, Baune BT. PMID: 32203155.
      View in: PubMed   Mentions:    Fields:    
    5. Using Chronobiological Phenotypes to Address Heterogeneity in Bipolar Disorder. Mol Neuropsychiatry. 2020 Apr; 5(Suppl 1):72-84. Gonzalez R, Gonzalez SD, McCarthy MJ. PMID: 32399471.
      View in: PubMed   Mentions:
    6. Identification and characterization of self-association domains on small ankyrin 1 isoforms. J Mol Cell Cardiol. 2020 02; 139:225-237. Subramaniam J, Yang P, McCarthy MJ, Cunha SR. PMID: 32035138.
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    7. Dopamine D2 receptor signaling modulates pancreatic beta cell circadian rhythms. Psychoneuroendocrinology. 2020 03; 113:104551. Wei H, Zapata RC, Lopez-Valencia M, Aslanoglou D, Farino ZJ, Benner V, Osborn O, Freyberg Z, McCarthy MJ. PMID: 31884319.
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    8. Pharmacological Manipulation of the Circadian Clock: A Possible Approach to the Management of Bipolar Disorder. CNS Drugs. 2019 10; 33(10):981-999. Porcu A, Gonzalez R, McCarthy MJ. PMID: 31625128.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. SCN11A mRNA levels in female bipolar disorder PBMCs as tentative biomarker for distinct patient sub-phenotypes. Drug Dev Res. 2019 12; 80(8):1128-1135. Voinsky I, McCarthy MJ, Shekhtman T, Kelsoe JR, Gurwitz D. PMID: 31498915.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. Entrainment of Circadian Rhythms to Temperature Reveals Amplitude Deficits in Fibroblasts from Patients with Bipolar Disorder and Possible Links to Calcium Channels. Mol Neuropsychiatry. 2019 Apr; 5(2):115-124. Nudell V, Wei H, Nievergelt C, Maihofer AX, Shilling P, Alda M, Berrettini WH, Brennand KJ, Calabrese JR, Coryell WH, Covault JM, Frye MA, Gage F, Gershon E, McInnis MG, Nurnberger JI, Oedegaard KJ, Shekhtman T, Zandi PP, Kelsoe JR, McCarthy MJ. PMID: 31192224.
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    11. Missing a beat: assessment of circadian rhythm abnormalities in bipolar disorder in the genomic era. Psychiatr Genet. 2019 04; 29(2):29-36. McCarthy MJ. PMID: 30516584.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    12. A functional variant in the serotonin receptor 7 gene (HTR7), rs7905446, is associated with good response to SSRIs in bipolar and unipolar depression. Mol Psychiatry. 2020 06; 25(6):1312-1322. Wei YB, McCarthy M, Ren H, Carrillo-Roa T, Shekhtman T, DeModena A, Liu JJ, Leckband SG, Mors O, Rietschel M, Henigsberg N, Cattaneo A, Binder EB, Aitchison KJ, Kelsoe JR. PMID: 30874608.
      View in: PubMed   Mentions: 3     Fields:    
    13. Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector Binding. ACS Omega. 2019 Feb 28; 4(2):2921-2930. McCarthy MJ, Pagba CV, Prakash P, Naji AK, van der Hoeven D, Liang H, Gupta AK, Zhou Y, Cho KJ, Hancock JF, Gorfe AA. PMID: 30842983.
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    14. Study of 45 candidate genes suggests CACNG2 may be associated with lithium response in bipolar disorder. J Affect Disord. 2019 04 01; 248:175-179. Miranda A, Shekhtman T, McCarthy M, DeModena A, Leckband SG, Kelsoe JR. PMID: 30738251.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder. Neuropsychopharmacology. 2019 02; 44(3):620-628. McCarthy MJ, Wei H, Nievergelt CM, Stautland A, Maihofer AX, Welsh DK, Shilling P, Alda M, Alliey-Rodriguez N, Anand A, Andreasson OA, Balaraman Y, Berrettini WH, Bertram H, Brennand KJ, Calabrese JR, Calkin CV, Claasen A, Conroy C, Coryell WH, Craig DW, D'Arcangelo N, Demodena A, Djurovic S, Feeder S, Fisher C, Frazier N, Frye MA, Gage FH, Gao K, Garnham J, Gershon ES, Glazer K, Goes F, Goto T, Harrington G, Jakobsen P, Kamali M, Karberg E, Kelly M, Leckband SG, Lohoff F, McInnis MG, Mondimore F, Morken G, Nurnberger JI, Obral S, Oedegaard KJ, Ortiz A, Ritchey M, Ryan K, Schinagle M, Schoeyen H, Schwebel C, Shaw M, Shekhtman T, Slaney C, Stapp E, Szelinger S, Tarwater B, Zandi PP, Kelsoe JR. PMID: 30487653.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    16. Does the Time of Drug Administration Alter the Metabolic Risk of Aripiprazole? Front Psychiatry. 2018; 9:494. Chipchura DA, Freyberg Z, Edwards C, Leckband SG, McCarthy MJ. PMID: 30364286.
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    17. Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study. Bipolar Disord. 2019 02; 21(1):68-75. Kalman JL, Papiol S, Forstner AJ, Heilbronner U, Degenhardt F, Strohmaier J, Adli M, Adorjan K, Akula N, Alda M, Anderson-Schmidt H, Andlauer TF, Anghelescu IG, Ardau R, Arias B, Arolt V, Aubry JM, Backlund L, Bartholdi K, Bauer M, Baune BT, Becker T, Bellivier F, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Brichant-Petitjean C, Budde M, Cervantes P, Chillotti C, Cichon S, Clark SR, Colom F, Comes AL, Cruceanu C, Czerski PM, Dannlowski U, Dayer A, Del Zompo M, DePaulo JR, Dietrich DE, Étain B, Ethofer T, Falkai P, Fallgatter A, Figge C, Flatau L, Folkerts H, Frisen L, Frye MA, Fullerton JM, Gade K, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Gryaznova A, Hake M, Hauser J, Herms S, Hoffmann P, Hou L, Jäger M, Jamain S, Jiménez E, Juckel G, Kahn JP, Kassem L, Kelsoe J, Kittel-Schneider S, Kliwicki S, Klohn-Sagatholislam F, Koller M, König B, Konrad C, Lackner N, Laje G, Landén M, Lang FU, Lavebratt C, Leboyer M, Leckband SG, Maj M, Manchia M, Martinsson L, McCarthy MJ, McElroy SL, McMahon FJ, Mitchell PB, Mitjans M, Mondimore FM, Monteleone P, Nieratschker V, Nievergelt CM, Novák T, Ösby U, Pfennig A, Potash JB, Reich-Erkelenz D, Reif A, Reimer J, Reininghaus E, Reitt M, Ripke S, Rouleau GA, Rybakowski JK, Schalling M, Scherk H, Schmauß M, Schofield PR, Schubert KO, Schulte EC, Schulz S, Senner F, Severino G, Shekhtman T, Shilling PD, Simhandl C, Slaney CM, Spitzer C, Squassina A, Stamm T, Stegmaier S, Stierl S, Stopkova P, Thiel A, Tighe SK, Tortorella A, Turecki G, Vieta E, Veeh J, von Hagen M, Wigand ME, Wiltfang J, Witt S, Wright A, Zandi PP, Zimmermann J, Nöthen M, Rietschel M, Schulze TG. PMID: 29956436.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    18. Recent Advancements in Treating Sleep Disorders in Co-Occurring PTSD. Curr Psychiatry Rep. 2018 06 21; 20(7):48. Colvonen PJ, Straus LD, Stepnowsky C, McCarthy MJ, Goldstein LA, Norman SB. PMID: 29931537.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    19. Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder. Front Psychiatry. 2018; 9:207. Reinbold CS, Forstner AJ, Hecker J, Fullerton JM, Hoffmann P, Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Marie-Claire C, Cervantes P, Chen GB, Chen HC, Chillotti C, Clark SR, Colom F, Cousins DA, Cruceanu C, Czerski PM, Dayer A, Étain B, Falkai P, Frisén L, Gard S, Garnham JS, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Herms S, Jamain S, Jiménez E, Kahn JP, Kassem L, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Lackner N, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, López Jaramillo CA, MacQueen G, Manchia M, Martinsson L, Mattheisen M, McCarthy MJ, McElroy SL, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Ösby U, Ozaki N, Perlis RH, Pfennig A, Reich-Erkelenz D, Rouleau GA, Schofield PR, Schubert KO, Schweizer BW, Seemüller F, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Smoller JW, Squassina A, Stamm TJ, Stopkova P, Tighe SK, Tortorella A, Turecki G, Volkert J, Witt SH, Wright AJ, Young LT, Zandi PP, Potash JB, DePaulo JR, Bauer M, Reininghaus E, Novák T, Aubry JM, Maj M, Baune BT, Mitchell PB, Vieta E, Frye MA, Rybakowski JK, Kuo PH, Kato T, Grigoroiu-Serbanescu M, Reif A, Del Zompo M, Bellivier F, Schalling M, Wray NR, Kelsoe JR, Alda M, McMahon FJ, Schulze TG, Rietschel M, Nöthen MM, Cichon S. PMID: 29904359.
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    20. Genome-wide analysis of insomnia disorder. Mol Psychiatry. 2018 11; 23(11):2238-2250. Stein MB, McCarthy MJ, Chen CY, Jain S, Gelernter J, He F, Heeringa SG, Kessler RC, Nock MK, Ripke S, Sun X, Wynn GH, Smoller JW, Ursano RJ. PMID: 29520036.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    21. A common genetic variant in CACNA1C predicts heart rate in patients with bipolar disorder. Psychiatry Res. 2018 05; 263:294-295. McCarthy MJ, Korelova O, Demodena A, Kelsoe JR. PMID: 29395250.
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    22. Inositol polyphosphates contribute to cellular circadian rhythms: Implications for understanding lithium's molecular mechanism. Cell Signal. 2018 04; 44:82-91. Wei H, Landgraf D, Wang G, McCarthy MJ. PMID: 29331582.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    23. Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study. JAMA Psychiatry. 2018 01 01; 75(1):65-74. Amare AT, Schubert KO, Hou L, Clark SR, Papiol S, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hsu YH, Shekhtman T, Adli M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, Bengesser S, Biernacka JM, Birner A, Brichant-Petitjean C, Cervantes P, Chen HC, Chillotti C, Cichon S, Cruceanu C, Czerski PM, Dalkner N, Dayer A, Del Zompo M, DePaulo JR, Étain B, Falkai P, Forstner AJ, Frisen L, Frye MA, Fullerton JM, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jiménez E, Kahn JP, Kassem L, Kuo PH, Kato T, Kelsoe J, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Tortorella A, Manchia M, Martinsson L, McCarthy MJ, McElroy S, Colom F, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Novák T, O'Donovan C, Ozaki N, Ösby U, Pfennig A, Potash JB, Reif A, Reininghaus E, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schweizer BW, Severino G, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Maj M, Turecki G, Vieta E, Volkert J, Witt S, Wright A, Zandi PP, Mitchell PB, Bauer M, Alda M, Rietschel M, McMahon FJ, Schulze TG, Baune BT. PMID: 29121268.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    24. Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis. Proc Natl Acad Sci U S A. 2017 05 30; 114(22):E4462-E4471. Tobe BTD, Crain AM, Winquist AM, Calabrese B, Makihara H, Zhao WN, Lalonde J, Nakamura H, Konopaske G, Sidor M, Pernia CD, Yamashita N, Wada M, Inoue Y, Nakamura F, Sheridan SD, Logan RW, Brandel M, Wu D, Hunsberger J, Dorsett L, Duerr C, Basa RCB, McCarthy MJ, Udeshi ND, Mertins P, Carr SA, Rouleau GA, Mastrangelo L, Li J, Gutierrez GJ, Brill LM, Venizelos N, Chen G, Nye JS, Manji H, Price JH, McClung CA, Akiskal HS, Alda M, Chuang DM, Coyle JT, Liu Y, Teng YD, Ohshima T, Mikoshiba K, Sidman RL, Halpain S, Haggarty SJ, Goshima Y, Snyder EY. PMID: 28500272.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    25. Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1. Alzheimers Dement. 2017 Jun; 13(6):689-700. Cronin P, McCarthy MJ, Lim ASP, Salmon DP, Galasko D, Masliah E, De Jager PL, Bennett DA, Desplats P. PMID: 27883893.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    26. Caregiving for youth with co-occurring developmental disabilities and behavioral health issues when caregivers face additional health-related stressors: Analysis of risk and protective factors from a national sample. Res Dev Disabil. 2016 Dec; 59:399-409. McCarthy MJ, Behimer G, Anderson JA, Riddle I. PMID: 27721195.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder. Hum Mol Genet. 2016 08 01; 25(15):3383-3394. Hou L, Bergen SE, Akula N, Song J, Hultman CM, Landén M, Adli M, Alda M, Ardau R, Arias B, Aubry JM, Backlund L, Badner JA, Barrett TB, Bauer M, Baune BT, Bellivier F, Benabarre A, Bengesser S, Berrettini WH, Bhattacharjee AK, Biernacka JM, Birner A, Bloss CS, Brichant-Petitjean C, Bui ET, Byerley W, Cervantes P, Chillotti C, Cichon S, Colom F, Coryell W, Craig DW, Cruceanu C, Czerski PM, Davis T, Dayer A, Degenhardt F, Del Zompo M, DePaulo JR, Edenberg HJ, Étain B, Falkai P, Foroud T, Forstner AJ, Frisén L, Frye MA, Fullerton JM, Gard S, Garnham JS, Gershon ES, Goes FS, Greenwood TA, Grigoroiu-Serbanescu M, Hauser J, Heilbronner U, Heilmann-Heimbach S, Herms S, Hipolito M, Hitturlingappa S, Hoffmann P, Hofmann A, Jamain S, Jiménez E, Kahn JP, Kassem L, Kelsoe JR, Kittel-Schneider S, Kliwicki S, Koller DL, König B, Lackner N, Laje G, Lang M, Lavebratt C, Lawson WB, Leboyer M, Leckband SG, Liu C, Maaser A, Mahon PB, Maier W, Maj M, Manchia M, Martinsson L, McCarthy MJ, McElroy SL, McInnis MG, McKinney R, Mitchell PB, Mitjans M, Mondimore FM, Monteleone P, Mühleisen TW, Nievergelt CM, Nöthen MM, Novák T, Nurnberger JI, Nwulia EA, Ösby U, Pfennig A, Potash JB, Propping P, Reif A, Reininghaus E, Rice J, Rietschel M, Rouleau GA, Rybakowski JK, Schalling M, Scheftner WA, Schofield PR, Schork NJ, Schulze TG, Schumacher J, Schweizer BW, Severino G, Shekhtman T, Shilling PD, Simhandl C, Slaney CM, Smith EN, Squassina A, Stamm T, Stopkova P, Streit F, Strohmaier J, Szelinger S, Tighe SK, Tortorella A, Turecki G, Vieta E, Volkert J, Witt SH, Wright A, Zandi PP, Zhang P, Zollner S, McMahon FJ. PMID: 27329760.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    28. Disinhibition of the extracellular-signal-regulated kinase restores the amplification of circadian rhythms by lithium in cells from bipolar disorder patients. Eur Neuropsychopharmacol. 2016 08; 26(8):1310-9. McCarthy MJ, Wei H, Landgraf D, Le Roux MJ, Welsh DK. PMID: 27216486.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    29. The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample. BMC Psychiatry. 2016 May 05; 16:129. Oedegaard KJ, Alda M, Anand A, Andreassen OA, Balaraman Y, Berrettini WH, Bhattacharjee A, Brennand KJ, Burdick KE, Calabrese JR, Calkin CV, Claasen A, Coryell WH, Craig D, DeModena A, Frye M, Gage FH, Gao K, Garnham J, Gershon E, Jakobsen P, Leckband SG, McCarthy MJ, McInnis MG, Maihofer AX, Mertens J, Morken G, Nievergelt CM, Nurnberger J, Pham S, Schoeyen H, Shekhtman T, Shilling PD, Szelinger S, Tarwater B, Yao J, Zandi PP, Kelsoe JR. PMID: 27150464.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    30. Suicide rates rise sharply in the US, figures show. BMJ. 2016 04 25; 353:i2355. McCarthy M. PMID: 27112501.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    31. The mood stabilizer valproic acid opposes the effects of dopamine on circadian rhythms. Neuropharmacology. 2016 08; 107:262-270. Landgraf D, Joiner WJ, McCarthy MJ, Kiessling S, Barandas R, Young JW, Cermakian N, Welsh DK. PMID: 27033596.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    32. Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study. Lancet. 2016 Mar 12; 387(10023):1085-1093. Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Banzato CEM, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Brichant-Petitjean C, Bui ET, Cervantes P, Chen GB, Chen HC, Chillotti C, Cichon S, Clark SR, Colom F, Cousins DA, Cruceanu C, Czerski PM, Dantas CR, Dayer A, Étain B, Falkai P, Forstner AJ, Frisén L, Fullerton JM, Gard S, Garnham JS, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jiménez E, Kahn JP, Kassem L, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Lackner N, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Jaramillo CAL, MacQueen G, Manchia M, Martinsson L, Mattheisen M, McCarthy MJ, McElroy SL, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Ösby U, Ozaki N, Perlis RH, Pfennig A, Reich-Erkelenz D, Rouleau GA, Schofield PR, Schubert KO, Schweizer BW, Seemüller F, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Smoller JW, Squassina A, Stamm T, Stopkova P, Tighe SK, Tortorella A, Turecki G, Volkert J, Witt S, Wright A, Young LT, Zandi PP, Potash JB, DePaulo JR, Bauer M, Reininghaus EZ, Novák T, Aubry JM, Maj M, Baune BT, Mitchell PB, Vieta E, Frye MA, Rybakowski JK, Kuo PH, Kato T, Grigoroiu-Serbanescu M, Reif A, Del Zompo M, Bellivier F, Schalling M, Wray NR, Kelsoe JR, Alda M, Rietschel M, McMahon FJ, Schulze TG. PMID: 26806518.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCTClinical Trials
    33. Circadian Clocks as Modulators of Metabolic Comorbidity in Psychiatric Disorders. Curr Psychiatry Rep. 2015 Dec; 17(12):98. Barandas R, Landgraf D, McCarthy MJ, Welsh DK. PMID: 26483181.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    34. Erratum: Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature. 2016 Feb 11; 530(7589):242. Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames T, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, Calabrese JR, Oedegaard KJ, McCarthy MJ, Zandi PP, Alda M, Nievergelt CM, Mi S, Brennand KJ, Kelsoe JR, Gage FH, Yao J. PMID: 26605530.
      View in: PubMed   Mentions: 3     Fields:    
    35. Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature. 2015 Nov 05; 527(7576):95-9. Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames T, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, Calabrese JR, Ødegaard KJ, McCarthy MJ, Zandi PP, Alda M, Alba M, Nievergelt CM, Mi S, Brennand KJ, Kelsoe JR, Gage FH, Yao J. PMID: 26524527.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansCells
    36. Calcium channel genes associated with bipolar disorder modulate lithium's amplification of circadian rhythms. Neuropharmacology. 2016 Feb; 101:439-48. McCarthy MJ, Le Roux MJ, Wei H, Beesley S, Kelsoe JR, Welsh DK. PMID: 26476274.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    37. Only 30% of Americans with HIV have virus in check, finds report. BMJ. 2014 Nov 27; 349:g7329. McCarthy M. PMID: 25429969.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    38. Circadian clock and stress interactions in the molecular biology of psychiatric disorders. Curr Psychiatry Rep. 2014 Oct; 16(10):483. Landgraf D, McCarthy MJ, Welsh DK. PMID: 25135782.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    39. Whole brain expression of bipolar disorder associated genes: structural and genetic analyses. PLoS One. 2014; 9(6):e100204. McCarthy MJ, Liang S, Spadoni AD, Kelsoe JR, Simmons AN. PMID: 24941232.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    40. Towards the clinical implementation of pharmacogenetics in bipolar disorder. BMC Med. 2014 May 30; 12:90. Salloum NC, McCarthy MJ, Leckband SG, Kelsoe JR. PMID: 24885933.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    41. The role of the circadian clock in animal models of mood disorders. Behav Neurosci. 2014 Jun; 128(3):344-59. Landgraf D, McCarthy MJ, Welsh DK. PMID: 24660657.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    42. Oxidative stress: a link between cardiovascular disease and psychiatric illness? Acta Psychiatr Scand. 2014 Sep; 130(3):161-2. McCarthy MJ. PMID: 24660876.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    43. Circadian clocks, brain function, and development. Ann N Y Acad Sci. 2013 Dec; 1306:43-67. Frank E, Sidor MM, Gamble KL, Cirelli C, Sharkey KM, Hoyle N, Tikotzky L, Talbot LS, McCarthy MJ, Hasler BP. PMID: 24329517.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    44. Genetic and clinical factors predict lithium's effects on PER2 gene expression rhythms in cells from bipolar disorder patients. Transl Psychiatry. 2013 Oct 22; 3:e318. McCarthy MJ, Wei H, Marnoy Z, Darvish RM, McPhie DL, Cohen BM, Welsh DK. PMID: 24150227.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    45. Circadian clock period inversely correlates with illness severity in cells from patients with alcohol use disorders. Alcohol Clin Exp Res. 2013 Aug; 37(8):1304-10. McCarthy MJ, Fernandes M, Kranzler HR, Covault JM, Welsh DK. PMID: 23550834.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    46. Adjunctive agomelatine therapy in the treatment of acute bipolar II depression: a preliminary open label study. Neuropsychiatr Dis Treat. 2013; 9:243-51. Fornaro M, McCarthy MJ, De Berardis D, De Pasquale C, Tabaton M, Martino M, Colicchio S, Cattaneo CI, D'Angelo E, Fornaro P. PMID: 23430979.
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    47. Cellular circadian clocks in mood disorders. J Biol Rhythms. 2012 Oct; 27(5):339-52. McCarthy MJ, Welsh DK. PMID: 23010657.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimals
    48. A survey of genomic studies supports association of circadian clock genes with bipolar disorder spectrum illnesses and lithium response. PLoS One. 2012; 7(2):e32091. McCarthy MJ, Nievergelt CM, Kelsoe JR, Welsh DK. PMID: 22384149.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    49. CREB involvement in the regulation of striatal prodynorphin by nicotine. Psychopharmacology (Berl). 2012 May; 221(1):143-53. McCarthy MJ, Duchemin AM, Neff NH, Hadjiconstantinou M. PMID: 22086359.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    50. Polymorphisms in melatonin synthesis pathways: possible influences on depression. J Circadian Rhythms. 2011 Aug 09; 9:8. Kripke DF, Nievergelt CM, Tranah GJ, Murray SS, McCarthy MJ, Rex KM, Parimi N, Kelsoe JR. PMID: 21827647.
      View in: PubMed   Mentions:
    51. The eyes are the window to the brain: reviewing oculomotor abnormalities in obsessive-compulsive disorder. Acta Psychiatr Scand. 2011 Aug; 124(2):85-6. McCarthy MJ. PMID: 21740402.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    52. Desensitization of d-opioid receptors in nucleus accumbens during nicotine withdrawal. Psychopharmacology (Berl). 2011 Feb; 213(4):735-44. McCarthy MJ, Zhang H, Neff NH, Hadjiconstantinou M. PMID: 20941594.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    53. Pharmacogenetics of lithium response in bipolar disorder. Pharmacogenomics. 2010 Oct; 11(10):1439-65. McCarthy MJ, Leckband SG, Kelsoe JR. PMID: 21047205.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    54. Nicotine withdrawal and kappa-opioid receptors. Psychopharmacology (Berl). 2010 Jun; 210(2):221-9. McCarthy MJ, Zhang H, Neff NH, Hadjiconstantinou M. PMID: 19806344.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    55. Allele specific analysis of the ADRBK2 gene in lymphoblastoid cells from bipolar disorder patients. J Psychiatr Res. 2010 Mar; 44(4):201-8. McCarthy MJ, Barrett TB, Nissen S, Kelsoe JR, Turner EE. PMID: 19766236.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    56. Internet monitoring of suicide risk in the population. J Affect Disord. 2010 May; 122(3):277-9. McCarthy MJ. PMID: 19748681.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
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