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Simon Schenk

Title(s)Associate Professor, Orthopedic Surgery
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    University of Michigan, Ann ArborPh.D.04/2006Kinesiology
    University of Texas, AustinM.A.8/2002Exercise Physiology
    University of Queensland, Brisbane, AustraliaB. Applied Science11/1999Human Movement Studies

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    p300/CBP, acetylation and muscle force generation
    NIH/NIAMS R21AR072882May 15, 2018 - Feb 29, 2020
    Role: Principal Investigator
    SIRTI and Adaptive Muscle Growth
    NIH/NIAMS R21AR069775Mar 1, 2016 - Feb 28, 2019
    Role: Principal Investigator
    SIRT1 and muscle insulin sensitivity
    NIH/NIA R01AG043120Aug 1, 2012 - May 31, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Metabolic Syndrome Is Associated With Higher Risk of Wound Complications After Total Hip Arthroplasty. Arthroplast Today. 2020 Sep; 6(3):571-577. Cheng KY, Ball ST, Gonzales FB, Schenk S, Hughes-Austin JM. PMID: 32802927.
      View in: PubMed   Mentions:
    2. p300 and cAMP response element-binding protein-binding protein in skeletal muscle homeostasis, contractile function, and survival. J Cachexia Sarcopenia Muscle. 2020 04; 11(2):464-477. Svensson K, LaBarge SA, Sathe A, Martins VF, Tahvilian S, Cunliffe JM, Sasik R, Mahata SK, Meyer GA, Philp A, David LL, Ward SR, McCurdy CE, Aslan JE, Schenk S. PMID: 31898871.
      View in: PubMed   Mentions:    Fields:    
    3. Combined overexpression of SIRT1 and knockout of GCN5 in adult skeletal muscle does not affect glucose homeostasis or exercise performance in mice. Am J Physiol Endocrinol Metab. 2020 02 01; 318(2):E145-E151. Svensson K, Tahvilian S, Martins VF, Dent JR, Lemanek A, Barooni N, Greyslak K, McCurdy CE, Schenk S. PMID: 31794263.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Skeletal muscle mitochondrial function and exercise capacity are not impaired in mice with knockout of STAT3. J Appl Physiol (1985). 2019 10 01; 127(4):1117-1127. Dent JR, Hetrick B, Tahvilian S, Sathe A, Greyslak K, LaBarge SA, Svensson K, McCurdy CE, Schenk S. PMID: 31513449.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Acute inhibition of protein deacetylases does not impact skeletal muscle insulin action. Am J Physiol Cell Physiol. 2019 11 01; 317(5):C964-C968. Martins VF, Begur M, Lakkaraju S, Svensson K, Park J, Hetrick B, McCurdy CE, Schenk S. PMID: 31461343.
      View in: PubMed   Mentions:
    6. Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity. Am J Physiol Endocrinol Metab. 2019 06 01; 316(6):E1024-E1035. Martins VF, Dent JR, Svensson K, Tahvilian S, Begur M, Lakkaraju S, Buckner EH, LaBarge SA, Hetrick B, McCurdy CE, Schenk S. PMID: 30888860.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    7. Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution. Proc Biol Sci. 2018 09 12; 285(1886). Okerblom J, Fletes W, Patel HH, Schenk S, Varki A, Breen EC. PMID: 30209232.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    8. Defining the contribution of skeletal muscle pyruvate dehydrogenase a1 to exercise performance and insulin action. Am J Physiol Endocrinol Metab. 2018 11 01; 315(5):E1034-E1045. Svensson K, Dent JR, Tahvilian S, Martins VF, Sathe A, Ochala J, Patel MS, Schenk S. PMID: 30153068.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    9. Calorie Restriction-Induced Increase in Skeletal Muscle Insulin Sensitivity Is Not Prevented by Overexpression of the p55a Subunit of Phosphoinositide 3-Kinase. Front Physiol. 2018; 9:789. Martins VF, Tahvilian S, Kang JH, Svensson K, Hetrick B, Chick WS, Schenk S, McCurdy CE. PMID: 29997524.
      View in: PubMed   Mentions:
    10. Cysteine- and glycine-rich protein 3 regulates glucose homeostasis in skeletal muscle. Am J Physiol Endocrinol Metab. 2018 08 01; 315(2):E267-E278. Hernandez-Carretero A, Weber N, LaBarge SA, Peterka V, Doan NYT, Schenk S, Osborn O. PMID: 29634311.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    11. Heterogeneous muscle gene expression patterns in patients with massive rotator cuff tears. PLoS One. 2018; 13(1):e0190439. Gibbons MC, Fisch KM, Pichika R, Cheng T, Engler AJ, Schenk S, Lane JG, Singh A, Ward SR. PMID: 29293645.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. Temporal overexpression of SIRT1 in skeletal muscle of adult mice does not improve insulin sensitivity or markers of mitochondrial biogenesis. Acta Physiol (Oxf). 2017 Nov; 221(3):193-203. Svensson K, LaBarge SA, Martins VF, Schenk S. PMID: 28544355.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    13. Histological Evidence of Muscle Degeneration in Advanced Human Rotator Cuff Disease. J Bone Joint Surg Am. 2017 Feb 01; 99(3):190-199. Gibbons MC, Singh A, Anakwenze O, Cheng T, Pomerantz M, Schenk S, Engler AJ, Ward SR. PMID: 28145949.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    14. Are the increasing amounts of gadolinium in surface and tap water dangerous? Acta Radiol. 2017 Mar; 58(3):259-263. Thomsen HS. PMID: 27609906.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Skeletal muscle fiber-type specific succinate dehydrogenase activity in cerebral palsy. Muscle Nerve. 2017 01; 55(1):122-124. Zogby AM, Dayanidhi S, Chambers HG, Schenk S, Lieber RL. PMID: 27515237.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    16. Muscle architectural changes after massive human rotator cuff tear. J Orthop Res. 2016 12; 34(12):2089-2095. Gibbons MC, Sato EJ, Bachasson D, Cheng T, Azimi H, Schenk S, Engler AJ, Singh A, Ward SR. PMID: 27061583.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    17. p300 is not required for metabolic adaptation to endurance exercise training. FASEB J. 2016 Apr; 30(4):1623-33. LaBarge SA, Migdal CW, Buckner EH, Okuno H, Gertsman I, Stocks B, Barshop BA, Nalbandian SR, Philp A, McCurdy CE, Schenk S. PMID: 26712218.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    18. Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle. FASEB J. 2016 Feb; 30(2):674-87. Cho Y, Hazen BC, Gandra PG, Ward SR, Schenk S, Russell AP, Kralli A. PMID: 26481306.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    19. Knockout of STAT3 in skeletal muscle does not prevent high-fat diet-induced insulin resistance. Mol Metab. 2015 Aug; 4(8):569-75. White AT, LaBarge SA, McCurdy CE, Schenk S. PMID: 26266089.
      View in: PubMed   Mentions: 12     Fields:    
    20. Is acetylation a metabolic rheostat that regulates skeletal muscle insulin action? Mol Cells. 2015 Apr; 38(4):297-303. LaBarge S, Migdal C, Schenk S. PMID: 25824547.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    21. Knock-down of IL-1Ra in obese mice decreases liver inflammation and improves insulin sensitivity. PLoS One. 2014; 9(9):e107487. Franck N, Maris M, Nalbandian S, Talukdar S, Schenk S, Hofmann HP, Bullough D, Osborn O. PMID: 25244011.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    22. Muscle gene expression patterns in human rotator cuff pathology. J Bone Joint Surg Am. 2014 Sep 17; 96(18):1558-65. Choo A, McCarthy M, Pichika R, Sato EJ, Lieber RL, Schenk S, Lane JG, Ward SR. PMID: 25232080.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    23. High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression. Am J Physiol Endocrinol Metab. 2014 Nov 01; 307(9):E764-72. White AT, Philp A, Fridolfsson HN, Schilling JM, Murphy AN, Hamilton DL, McCurdy CE, Patel HH, Schenk S. PMID: 25159328.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    24. Increased adipocyte O2 consumption triggers HIF-1a, causing inflammation and insulin resistance in obesity. Cell. 2014 Jun 05; 157(6):1339-1352. Lee YS, Kim JW, Osborne O, Oh DY, Sasik R, Schenk S, Chen A, Chung H, Murphy A, Watkins SM, Quehenberger O, Johnson RS, Olefsky JM. PMID: 24906151.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    25. Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice. Diabetologia. 2013 Jul; 56(7):1629-37. White AT, McCurdy CE, Philp A, Hamilton DL, Johnson CD, Schenk S. PMID: 23604553.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    26. Role of the cytoskeleton in muscle transcriptional responses to altered use. Physiol Genomics. 2013 Apr 16; 45(8):321-31. Meyer GA, Schenk S, Lieber RL. PMID: 23444318.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    27. G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice. J Clin Invest. 2012 Jul; 122(7):2444-53. Osborn O, Oh DY, McNelis J, Sanchez-Alavez M, Talukdar S, Lu M, Li P, Thiede L, Morinaga H, Kim JJ, Heinrichsdorff J, Nalbandian S, Ofrecio JM, Scadeng M, Schenk S, Hadcock J, Bartfai T, Olefsky JM. PMID: 22653059.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    28. NAD(+)/NADH and skeletal muscle mitochondrial adaptations to exercise. Am J Physiol Endocrinol Metab. 2012 Aug 01; 303(3):E308-21. White AT, Schenk S. PMID: 22436696.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    29. New opportunities and novel paradigms to support neuromuscular research. Phys Med Rehabil Clin N Am. 2012 Feb; 23(1):95-105, xi. Lieber R, Ward S, Frank L, Schenk S. PMID: 22239877.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. J Clin Invest. 2011 Nov; 121(11):4281-8. Schenk S, McCurdy CE, Philp A, Chen MZ, Holliday MJ, Bandyopadhyay GK, Osborn O, Baar K, Olefsky JM. PMID: 21985785.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    31. Inducible nitric oxide synthase deficiency in myeloid cells does not prevent diet-induced insulin resistance. Mol Endocrinol. 2010 Jul; 24(7):1413-22. Lu M, Li P, Pferdekamper J, Fan W, Saberi M, Schenk S, Olefsky JM. PMID: 20444886.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    32. A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats. Am J Physiol Endocrinol Metab. 2010 May; 298(5):E1036-48. Lu M, Patsouris D, Li P, Flores-Riveros J, Frincke JM, Watkins S, Schenk S, Olefsky JM. PMID: 20159859.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    33. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab. 2010 Mar; 298(3):E419-28. Yoshizaki T, Schenk S, Imamura T, Babendure JL, Sonoda N, Bae EJ, Oh DY, Lu M, Milne JC, Westphal C, Bandyopadhyay G, Olefsky JM. PMID: 19996381.
      View in: PubMed   Mentions: 129     Fields:    Translation:AnimalsCells
    34. Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab. 2009 Nov; 10(5):419-29. Saberi M, Woods NB, de Luca C, Schenk S, Lu JC, Bandyopadhyay G, Verma IM, Olefsky JM. PMID: 19883619.
      View in: PubMed   Mentions: 166     Fields:    Translation:AnimalsCells
    35. Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes. Am J Physiol Endocrinol Metab. 2009 Nov; 297(5):E1137-46. Saberi M, Bjelica D, Schenk S, Imamura T, Bandyopadhyay G, Li P, Jadhar V, Vargeese C, Wang W, Bowman K, Zhang Y, Polisky B, Olefsky JM. PMID: 19706791.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    36. A novel pathway of insulin sensitivity in chromogranin A null mice: a crucial role for pancreastatin in glucose homeostasis. J Biol Chem. 2009 Oct 16; 284(42):28498-509. Gayen JR, Saberi M, Schenk S, Biswas N, Vaingankar SM, Cheung WW, Najjar SM, O'Connor DT, Bandyopadhyay G, Mahata SK. PMID: 19706599.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    37. SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Mol Cell Biol. 2009 Mar; 29(5):1363-74. Yoshizaki T, Milne JC, Imamura T, Schenk S, Sonoda N, Babendure JL, Lu JC, Smith JJ, Jirousek MR, Olefsky JM. PMID: 19103747.
      View in: PubMed   Mentions: 146     Fields:    Translation:AnimalsCells
    38. Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest. 2008 Sep; 118(9):2992-3002. Schenk S, Saberi M, Olefsky JM. PMID: 18769626.
      View in: PubMed   Mentions: 385     Fields:    Translation:HumansAnimalsCells
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