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Simon Schenk

Title(s)Associate Professor In Residence, Orthopedic Surgery
SchoolHealth Sciences
Address9500 Gilman Drive #0863
La Jolla CA 92093
Phone858-822-0857
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    Collapse Biography 
    Collapse Education and Training
    University of Michigan, Ann ArborPh.D.04/2006Kinesiology
    University of Texas, AustinM.A.8/2002Exercise Physiology
    University of Queensland, Brisbane, AustraliaB. Applied Science11/1999Human Movement Studies

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    p300/CBP, acetylation and muscle force generation
    NIH/NIAMS R21AR072882May 15, 2018 - Feb 29, 2020
    Role: Principal Investigator
    SIRTI and Adaptive Muscle Growth
    NIH/NIAMS R21AR069775Mar 1, 2016 - Feb 28, 2019
    Role: Principal Investigator
    SIRT1 and muscle insulin sensitivity
    NIH/NIA R01AG043120Aug 1, 2012 - May 31, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise. Cell. 2020 Jun 25; 181(7):1464-1474. Sanford JA, Nogiec CD, Lindholm ME, Adkins JN, Amar D, Dasari S, Drugan JK, Fernández FM, Radom-Aizik S, Schenk S, Snyder MP, Tracy RP, Vanderboom P, Trappe S, Walsh MJ. PMID: 32589957.
      View in: PubMed   Mentions:    Fields:    
    2. Maternal Obesity and Western-Style Diet Impair Fetal and Juvenile Offspring Skeletal Muscle Insulin-Stimulated Glucose Transport in Nonhuman Primates. Diabetes. 2020 Jul; 69(7):1389-1400. Campodonico-Burnett W, Hetrick B, Wesolowski SR, Schenk S, Takahashi DL, Dean TA, Sullivan EL, Kievit P, Gannon M, Aagaard K, Friedman JE, McCurdy CE. PMID: 32354857.
      View in: PubMed   Mentions:    Fields:    
    3. p300 and cAMP response element-binding protein-binding protein in skeletal muscle homeostasis, contractile function, and survival. J Cachexia Sarcopenia Muscle. 2020 Apr; 11(2):464-477. Svensson K, LaBarge SA, Sathe A, Martins VF, Tahvilian S, Cunliffe JM, Sasik R, Mahata SK, Meyer GA, Philp A, David LL, Ward SR, McCurdy CE, Aslan JE, Schenk S. PMID: 31898871.
      View in: PubMed   Mentions:    Fields:    
    4. Combined overexpression of SIRT1 and knockout of GCN5 in adult skeletal muscle does not affect glucose homeostasis or exercise performance in mice. Am J Physiol Endocrinol Metab. 2020 02 01; 318(2):E145-E151. Svensson K, Tahvilian S, Martins VF, Dent JR, Lemanek A, Barooni N, Greyslak K, McCurdy CE, Schenk S. PMID: 31794263.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Skeletal muscle mitochondrial function and exercise capacity are not impaired in mice with knockout of STAT3. J Appl Physiol (1985). 2019 10 01; 127(4):1117-1127. Dent JR, Hetrick B, Tahvilian S, Sathe A, Greyslak K, LaBarge SA, Svensson K, McCurdy CE, Schenk S. PMID: 31513449.
      View in: PubMed   Mentions:    Fields:    
    6. Acute inhibition of protein deacetylases does not impact skeletal muscle insulin action. Am J Physiol Cell Physiol. 2019 11 01; 317(5):C964-C968. Martins VF, Begur M, Lakkaraju S, Svensson K, Park J, Hetrick B, McCurdy CE, Schenk S. PMID: 31461343.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    7. Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity. Am J Physiol Endocrinol Metab. 2019 06 01; 316(6):E1024-E1035. Martins VF, Dent JR, Svensson K, Tahvilian S, Begur M, Lakkaraju S, Buckner EH, LaBarge SA, Hetrick B, McCurdy CE, Schenk S. PMID: 30888860.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    8. Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution. Proc Biol Sci. 2018 09 12; 285(1886). Okerblom J, Fletes W, Patel HH, Schenk S, Varki A, Breen EC. PMID: 30209232.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    9. Defining the contribution of skeletal muscle pyruvate dehydrogenase a1 to exercise performance and insulin action. Am J Physiol Endocrinol Metab. 2018 11 01; 315(5):E1034-E1045. Svensson K, Dent JR, Tahvilian S, Martins VF, Sathe A, Ochala J, Patel MS, Schenk S. PMID: 30153068.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    10. Calorie Restriction-Induced Increase in Skeletal Muscle Insulin Sensitivity Is Not Prevented by Overexpression of the p55a Subunit of Phosphoinositide 3-Kinase. Front Physiol. 2018; 9:789. Martins VF, Tahvilian S, Kang JH, Svensson K, Hetrick B, Chick WS, Schenk S, McCurdy CE. PMID: 29997524.
      View in: PubMed   Mentions:
    11. Cysteine- and glycine-rich protein 3 regulates glucose homeostasis in skeletal muscle. Am J Physiol Endocrinol Metab. 2018 08 01; 315(2):E267-E278. Hernandez-Carretero A, Weber N, LaBarge SA, Peterka V, Doan NYT, Schenk S, Osborn O. PMID: 29634311.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    12. SIRT1 regulates nuclear number and domain size in skeletal muscle fibers. J Cell Physiol. 2018 09; 233(9):7157-7163. Ross JA, Levy Y, Svensson K, Philp A, Schenk S, Ochala J. PMID: 29574748.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    13. Heterogeneous muscle gene expression patterns in patients with massive rotator cuff tears. PLoS One. 2018; 13(1):e0190439. Gibbons MC, Fisch KM, Pichika R, Cheng T, Engler AJ, Schenk S, Lane JG, Singh A, Ward SR. PMID: 29293645.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Acute glucoregulatory and vascular outcomes of three strategies for interrupting prolonged sitting time in postmenopausal women: A pilot, laboratory-based, randomized, controlled, 4-condition, 4-period crossover trial. PLoS One. 2017; 12(11):e0188544. Kerr J, Crist K, Vital DG, Dillon L, Aden SA, Trivedi M, Castellanos LR, Godbole S, Li H, Allison MA, Khemlina GL, Takemoto ML, Schenk S, Sallis JF, Grace M, Dunstan DW, Natarajan L, LaCroix AZ, Sears DD. PMID: 29190761.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Exercise and high-fat feeding remodel transcript-metabolite interactive networks in mouse skeletal muscle. Sci Rep. 2017 10 18; 7(1):13485. Pérez-Schindler J, Kanhere A, Edwards L, Allwood JW, Dunn WB, Schenk S, Philp A. PMID: 29044196.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    16. Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation. Mol Metab. 2017 12; 6(12):1574-1584. Dent JR, Martins VF, Svensson K, LaBarge SA, Schlenk NC, Esparza MC, Buckner EH, Meyer GA, Hamilton DL, Schenk S, Philp A. PMID: 29111103.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    17. Overload-mediated skeletal muscle hypertrophy is not impaired by loss of myofiber STAT3. Am J Physiol Cell Physiol. 2017 Sep 01; 313(3):C257-C261. Pérez-Schindler J, Esparza MC, McKendry J, Breen L, Philp A, Schenk S. PMID: 28659288.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    18. Temporal overexpression of SIRT1 in skeletal muscle of adult mice does not improve insulin sensitivity or markers of mitochondrial biogenesis. Acta Physiol (Oxf). 2017 Nov; 221(3):193-203. Svensson K, LaBarge SA, Martins VF, Schenk S. PMID: 28544355.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    19. Dried Plum Ingestion Increases the Osteoblastogenic Capacity of Human Serum. J Med Food. 2017 Jul; 20(7):653-658. Delgado Cuenca P, Almaiman L, Schenk S, Kern M, Hooshmand S. PMID: 28445075.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    20. Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat Chem Biol. 2017 06; 13(6):624-632. Stanford SM, Aleshin AE, Zhang V, Ardecky RJ, Hedrick MP, Zou J, Ganji SR, Bliss MR, Yamamoto F, Bobkov AA, Kiselar J, Liu Y, Cadwell GW, Khare S, Yu J, Barquilla A, Chung TDY, Mustelin T, Schenk S, Bankston LA, Liddington RC, Pinkerton AB, Bottini N. PMID: 28346406.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    21. Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK. EBioMedicine. 2017 Apr; 18:128-138. Park SJ, Ahmad F, Um JH, Brown AL, Xu X, Kang H, Ke H, Feng X, Ryall J, Philp A, Schenk S, Kim MK, Sartorelli V, Chung JH. PMID: 28396013.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    22. mTOR regulates peripheral nerve response to tensile strain. J Neurophysiol. 2017 05 01; 117(5):2075-2084. Love JM, Bober BG, Orozco E, White AT, Bremner SN, Lovering RM, Schenk S, Shah SB. PMID: 28250148.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    23. Histological Evidence of Muscle Degeneration in Advanced Human Rotator Cuff Disease. J Bone Joint Surg Am. 2017 Feb 01; 99(3):190-199. Gibbons MC, Singh A, Anakwenze O, Cheng T, Pomerantz M, Schenk S, Engler AJ, Ward SR. PMID: 28145949.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    24. Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques. JCI Insight. 2016 Oct 06; 1(16):e86612. McCurdy CE, Schenk S, Hetrick B, Houck J, Drew BG, Kaye S, Lashbrook M, Bergman BC, Takahashi DL, Dean TA, Nemkov T, Gertsman I, Hansen KC, Philp A, Hevener AL, Chicco AJ, Aagaard KM, Grove KL, Friedman JE. PMID: 27734025.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    25. Are the increasing amounts of gadolinium in surface and tap water dangerous? Acta Radiol. 2017 Mar; 58(3):259-263. Thomsen HS. PMID: 27609906.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    26. Skeletal muscle fiber-type specific succinate dehydrogenase activity in cerebral palsy. Muscle Nerve. 2017 01; 55(1):122-124. Zogby AM, Dayanidhi S, Chambers HG, Schenk S, Lieber RL. PMID: 27515237.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    27. One-time injection of AAV8 encoding urocortin 2 provides long-term resolution of insulin resistance. JCI Insight. 2016 09 22; 1(15):e88322. Gao MH, Giamouridis D, Lai NC, Walenta E, Paschoal VA, Kim YC, Miyanohara A, Guo T, Liao M, Liu L, Tan Z, Ciaraldi TP, Schenk S, Bhargava A, Oh DY, Hammond HK. PMID: 27699250.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    28. Muscle architectural changes after massive human rotator cuff tear. J Orthop Res. 2016 12; 34(12):2089-2095. Gibbons MC, Sato EJ, Bachasson D, Cheng T, Azimi H, Schenk S, Engler AJ, Singh A, Ward SR. PMID: 27061583.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    29. Skeletal muscle action of estrogen receptor a is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Sci Transl Med. 2016 Apr 13; 8(334):334ra54. Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL. PMID: 27075628.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    30. p300 is not required for metabolic adaptation to endurance exercise training. FASEB J. 2016 Apr; 30(4):1623-33. LaBarge SA, Migdal CW, Buckner EH, Okuno H, Gertsman I, Stocks B, Barshop BA, Nalbandian SR, Philp A, McCurdy CE, Schenk S. PMID: 26712218.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    31. Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle. FASEB J. 2016 Feb; 30(2):674-87. Cho Y, Hazen BC, Gandra PG, Ward SR, Schenk S, Russell AP, Kralli A. PMID: 26481306.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    32. Rapamycin does not prevent increases in myofibrillar or mitochondrial protein synthesis following endurance exercise. J Physiol. 2015 Sep 15; 593(18):4275-84. Philp A, Schenk S, Perez-Schindler J, Hamilton DL, Breen L, Laverone E, Jeromson S, Phillips SM, Baar K. PMID: 26227152.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    33. Knockout of STAT3 in skeletal muscle does not prevent high-fat diet-induced insulin resistance. Mol Metab. 2015 Aug; 4(8):569-75. White AT, LaBarge SA, McCurdy CE, Schenk S. PMID: 26266089.
      View in: PubMed   Mentions: 11     Fields:    
    34. Is acetylation a metabolic rheostat that regulates skeletal muscle insulin action? Mol Cells. 2015 Apr; 38(4):297-303. LaBarge S, Migdal C, Schenk S. PMID: 25824547.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    35. Knock-down of IL-1Ra in obese mice decreases liver inflammation and improves insulin sensitivity. PLoS One. 2014; 9(9):e107487. Franck N, Maris M, Nalbandian S, Talukdar S, Schenk S, Hofmann HP, Bullough D, Osborn O. PMID: 25244011.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    36. Muscle gene expression patterns in human rotator cuff pathology. J Bone Joint Surg Am. 2014 Sep 17; 96(18):1558-65. Choo A, McCarthy M, Pichika R, Sato EJ, Lieber RL, Schenk S, Lane JG, Ward SR. PMID: 25232080.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    37. Interaction between lipid availability,endurance exercise and insulin sensitivity. Med Sport Sci. 2014; 60:62-70. Newsom SA, Schenk S. PMID: 25226801.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    38. Understanding the acetylome: translating targeted proteomics into meaningful physiology. Am J Physiol Cell Physiol. 2014 Nov 01; 307(9):C763-73. Philp A, Rowland T, Perez-Schindler J, Schenk S. PMID: 25186010.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    39. High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression. Am J Physiol Endocrinol Metab. 2014 Nov 01; 307(9):E764-72. White AT, Philp A, Fridolfsson HN, Schilling JM, Murphy AN, Hamilton DL, McCurdy CE, Patel HH, Schenk S. PMID: 25159328.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    40. Increased adipocyte O2 consumption triggers HIF-1a, causing inflammation and insulin resistance in obesity. Cell. 2014 Jun 05; 157(6):1339-52. Lee YS, Kim JW, Osborne O, Oh DY, Sasik R, Schenk S, Chen A, Chung H, Murphy A, Watkins SM, Quehenberger O, Johnson RS, Olefsky JM. PMID: 24906151.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    41. Application of the [?-32P] ATP kinase assay to study anabolic signaling in human skeletal muscle. J Appl Physiol (1985). 2014 Mar 01; 116(5):504-13. McGlory C, White A, Treins C, Drust B, Close GL, Maclaren DP, Campbell IT, Philp A, Schenk S, Morton JP, Hamilton DL. PMID: 24436296.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    42. Unraveling the complexities of SIRT1-mediated mitochondrial regulation in skeletal muscle. Exerc Sport Sci Rev. 2013 Jul; 41(3):174-81. Philp A, Schenk S. PMID: 23792490.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    43. Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice. Diabetologia. 2013 Jul; 56(7):1629-37. White AT, McCurdy CE, Philp A, Hamilton DL, Johnson CD, Schenk S. PMID: 23604553.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    44. Role of the cytoskeleton in muscle transcriptional responses to altered use. Physiol Genomics. 2013 Apr 16; 45(8):321-31. Meyer GA, Schenk S, Lieber RL. PMID: 23444318.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    45. Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance. Diabetes. 2013 Feb; 62(2):401-10. Boon J, Hoy AJ, Stark R, Brown RD, Meex RC, Henstridge DC, Schenk S, Meikle PJ, Horowitz JF, Kingwell BA, Bruce CR, Watt MJ. PMID: 23139352.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    46. Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization. J Lipid Res. 2012 Dec; 53(12):2610-9. Chao LC, Wroblewski K, Ilkayeva OR, Stevens RD, Bain J, Meyer GA, Schenk S, Martinez L, Vergnes L, Narkar VA, Drew BG, Hong C, Boyadjian R, Hevener AL, Evans RM, Reue K, Spencer MJ, Newgard CB, Tontonoz P. PMID: 23028113.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    47. Attenuated Pik3r1 expression prevents insulin resistance and adipose tissue macrophage accumulation in diet-induced obese mice. Diabetes. 2012 Oct; 61(10):2495-505. McCurdy CE, Schenk S, Holliday MJ, Philp A, Houck JA, Patsouris D, MacLean PS, Majka SM, Klemm DJ, Friedman JE. PMID: 22698915.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    48. G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice. J Clin Invest. 2012 Jul; 122(7):2444-53. Osborn O, Oh DY, McNelis J, Sanchez-Alavez M, Talukdar S, Lu M, Li P, Thiede L, Morinaga H, Kim JJ, Heinrichsdorff J, Nalbandian S, Ofrecio JM, Scadeng M, Schenk S, Hadcock J, Bartfai T, Olefsky JM. PMID: 22653059.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    49. NAD(+)/NADH and skeletal muscle mitochondrial adaptations to exercise. Am J Physiol Endocrinol Metab. 2012 Aug 01; 303(3):E308-21. White AT, Schenk S. PMID: 22436696.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    50. Commentaries on viewpoint: does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments? J Appl Physiol (1985). 2012 Mar; 112(5):929-30. Menzies KJ, Chabi B, Hood DA, Schenk S, Philp A, Philip A, Braga VA, Guimaraes DD. PMID: 22383496.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    51. New opportunities and novel paradigms to support neuromuscular research. Phys Med Rehabil Clin N Am. 2012 Feb; 23(1):95-105, xi. Lieber R, Ward S, Frank L, Schenk S. PMID: 22239877.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    52. Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. J Clin Invest. 2011 Nov; 121(11):4281-8. Schenk S, McCurdy CE, Philp A, Chen MZ, Holliday MJ, Bandyopadhyay GK, Osborn O, Baar K, Olefsky JM. PMID: 21985785.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    53. The PGC-1a-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes. Am J Physiol Regul Integr Comp Physiol. 2011 Oct; 301(4):R864-72. Philp A, Belew MY, Evans A, Pham D, Sivia I, Chen A, Schenk S, Baar K. PMID: 21795630.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    54. Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise. J Biol Chem. 2011 Sep 02; 286(35):30561-70. Philp A, Chen A, Lan D, Meyer GA, Murphy AN, Knapp AE, Olfert IM, McCurdy CE, Marcotte GR, Hogan MC, Baar K, Schenk S. PMID: 21757760.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    55. Inducible nitric oxide synthase deficiency in myeloid cells does not prevent diet-induced insulin resistance. Mol Endocrinol. 2010 Jul; 24(7):1413-22. Lu M, Li P, Pferdekamper J, Fan W, Saberi M, Schenk S, Olefsky JM. PMID: 20444886.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    56. A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats. Am J Physiol Endocrinol Metab. 2010 May; 298(5):E1036-48. Lu M, Patsouris D, Li P, Flores-Riveros J, Frincke JM, Watkins S, Schenk S, Olefsky JM. PMID: 20159859.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    57. Energy deficit after exercise augments lipid mobilization but does not contribute to the exercise-induced increase in insulin sensitivity. J Appl Physiol (1985). 2010 Mar; 108(3):554-60. Newsom SA, Schenk S, Thomas KM, Harber MP, Knuth ND, Goldenberg N, Horowitz JF. PMID: 20044472.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    58. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab. 2010 Mar; 298(3):E419-28. Yoshizaki T, Schenk S, Imamura T, Babendure JL, Sonoda N, Bae EJ, Oh DY, Lu M, Milne JC, Westphal C, Bandyopadhyay G, Olefsky JM. PMID: 19996381.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    59. Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab. 2009 Nov; 10(5):419-29. Saberi M, Woods NB, de Luca C, Schenk S, Lu JC, Bandyopadhyay G, Verma IM, Olefsky JM. PMID: 19883619.
      View in: PubMed   Mentions: 155     Fields:    Translation:AnimalsCells
    60. Improved insulin sensitivity after weight loss and exercise training is mediated by a reduction in plasma fatty acid mobilization, not enhanced oxidative capacity. J Physiol. 2009 Oct 15; 587(Pt 20):4949-61. Schenk S, Harber MP, Shrivastava CR, Burant CF, Horowitz JF. PMID: 19723783.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    61. A novel pathway of insulin sensitivity in chromogranin A null mice: a crucial role for pancreastatin in glucose homeostasis. J Biol Chem. 2009 Oct 16; 284(42):28498-509. Gayen JR, Saberi M, Schenk S, Biswas N, Vaingankar SM, Cheung WW, Najjar SM, O'Connor DT, Bandyopadhyay G, Mahata SK. PMID: 19706599.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    62. Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes. Am J Physiol Endocrinol Metab. 2009 Nov; 297(5):E1137-46. Saberi M, Bjelica D, Schenk S, Imamura T, Bandyopadhyay G, Li P, Jadhar V, Vargeese C, Wang W, Bowman K, Zhang Y, Polisky B, Olefsky JM. PMID: 19706791.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    63. Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators. J Med Chem. 2009 Mar 12; 52(5):1275-83. Vu CB, Bemis JE, Disch JS, Ng PY, Nunes JJ, Milne JC, Carney DP, Lynch AV, Smith JJ, Lavu S, Lambert PD, Gagne DJ, Jirousek MR, Schenk S, Olefsky JM, Perni RB. PMID: 19199480.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    64. SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Mol Cell Biol. 2009 Mar; 29(5):1363-74. Yoshizaki T, Milne JC, Imamura T, Schenk S, Sonoda N, Babendure JL, Lu JC, Smith JJ, Jirousek MR, Olefsky JM. PMID: 19103747.
      View in: PubMed   Mentions: 141     Fields:    Translation:AnimalsCells
    65. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature. 2008 Nov 13; 456(7219):269-73. Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates J, Olefsky J, Guarente L, Montminy M. PMID: 18849969.
      View in: PubMed   Mentions: 223     Fields:    Translation:HumansAnimalsCells
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