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Simon Schenk

TitleAssociate Professor In Residence
InstitutionUniversity of California San Diego
DepartmentOrthopedic Surgery
Address9500 Gilman Drive #0863
La Jolla CA 92093
Phone858-822-0857
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    Collapse Research 
    Collapse Research Activities and Funding
    p300/CBP, acetylation and muscle force generation
    NIH/NIAMS R21AR072882May 15, 2018 - Feb 29, 2020
    Role: Principal Investigator
    SIRTI and Adaptive Muscle Growth
    NIH/NIAMS R21AR069775Mar 1, 2016 - Feb 28, 2019
    Role: Principal Investigator
    SIRT1 and muscle insulin sensitivity
    NIH/NIA R01AG043120Aug 1, 2012 - Jul 31, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Svensson K, Dent JR, Tahvilian S, Martins VF, Sathe A, Ochala J, Patel MS, Schenk S. Defining the contribution of skeletal muscle pyruvate dehydrogenase alpha 1 (Pdha1) to exercise performance and insulin action. Am J Physiol Endocrinol Metab. 2018 Aug 28. PMID: 30153068.
      View in: PubMed
    2. Martins VF, Tahvilian S, Kang JH, Svensson K, Hetrick B, Chick WS, Schenk S, McCurdy CE. Calorie Restriction-Induced Increase in Skeletal Muscle Insulin Sensitivity Is Not Prevented by Overexpression of the p55a Subunit of Phosphoinositide 3-Kinase. Front Physiol. 2018; 9:789. PMID: 29997524.
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    3. Hernández-Carretero A, Weber N, LaBarge SA, Peterka V, Doan NYT, Schenk S, Osborn O. Cysteine and Glycine-Rich Protein 3 Regulates Glucose Homeostasis in Skeletal Muscle. Am J Physiol Endocrinol Metab. 2018 Apr 10. PMID: 29634311.
      View in: PubMed
    4. Ross JA, Levy Y, Svensson K, Philp A, Schenk S, Ochala J. SIRT1 regulates nuclear number and domain size in skeletal muscle fibers. J Cell Physiol. 2018 Mar 25. PMID: 29574748.
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    5. Gibbons MC, Fisch KM, Pichika R, Cheng T, Engler AJ, Schenk S, Lane JG, Singh A, Ward SR. Heterogeneous muscle gene expression patterns in patients with massive rotator cuff tears. PLoS One. 2018; 13(1):e0190439. PMID: 29293645.
      View in: PubMed
    6. Kerr J, Crist K, Vital DG, Dillon L, Aden SA, Trivedi M, Castellanos LR, Godbole S, Li H, Allison MA, Khemlina GL, Takemoto ML, Schenk S, Sallis JF, Grace M, Dunstan DW, Natarajan L, LaCroix AZ, Sears DD. Acute glucoregulatory and vascular outcomes of three strategies for interrupting prolonged sitting time in postmenopausal women: A pilot, laboratory-based, randomized, controlled, 4-condition, 4-period crossover trial. PLoS One. 2017; 12(11):e0188544. PMID: 29190761.
      View in: PubMed
    7. Pérez-Schindler J, Kanhere A, Edwards L, Allwood JW, Dunn WB, Schenk S, Philp A. Exercise and high-fat feeding remodel transcript-metabolite interactive networks in mouse skeletal muscle. Sci Rep. 2017 Oct 18; 7(1):13485. PMID: 29044196.
      View in: PubMed
    8. Dent JR, Martins VF, Svensson K, LaBarge SA, Schlenk NC, Esparza MC, Buckner EH, Meyer GA, Hamilton DL, Schenk S, Philp A. Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation. Mol Metab. 2017 Dec; 6(12):1574-1584. PMID: 29111103.
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    9. Pérez-Schindler J, Esparza MC, McKendry J, Breen L, Philp A, Schenk S. Overload-mediated skeletal muscle hypertrophy is not impaired by loss of myofiber STAT3. Am J Physiol Cell Physiol. 2017 Sep 01; 313(3):C257-C261. PMID: 28659288.
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    10. Delgado Cuenca P, Almaiman L, Schenk S, Kern M, Hooshmand S. Dried Plum Ingestion Increases the Osteoblastogenic Capacity of Human Serum. J Med Food. 2017 Jul; 20(7):653-658. PMID: 28445075.
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    11. Stanford SM, Aleshin AE, Zhang V, Ardecky RJ, Hedrick MP, Zou J, Ganji SR, Bliss MR, Yamamoto F, Bobkov AA, Kiselar J, Liu Y, Cadwell GW, Khare S, Yu J, Barquilla A, Chung TDY, Mustelin T, Schenk S, Bankston LA, Liddington RC, Pinkerton AB, Bottini N. Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat Chem Biol. 2017 06; 13(6):624-632. PMID: 28346406.
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    12. Park SJ, Ahmad F, Um JH, Brown AL, Xu X, Kang H, Ke H, Feng X, Ryall J, Philp A, Schenk S, Kim MK, Sartorelli V, Chung JH. Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK. EBioMedicine. 2017 Apr; 18:128-138. PMID: 28396013.
      View in: PubMed
    13. Love JM, Bober BG, Orozco E, White AT, Bremner SN, Lovering RM, Schenk S, Shah SB. mTOR regulates peripheral nerve response to tensile strain. J Neurophysiol. 2017 May 01; 117(5):2075-2084. PMID: 28250148.
      View in: PubMed
    14. Gibbons MC, Singh A, Anakwenze O, Cheng T, Pomerantz M, Schenk S, Engler AJ, Ward SR. Histological Evidence of Muscle Degeneration in Advanced Human Rotator Cuff Disease. J Bone Joint Surg Am. 2017 Feb 01; 99(3):190-199. PMID: 28145949.
      View in: PubMed
    15. McCurdy CE, Schenk S, Hetrick B, Houck J, Drew BG, Kaye S, Lashbrook M, Bergman BC, Takahashi DL, Dean TA, Nemkov T, Gertsman I, Hansen KC, Philp A, Hevener AL, Chicco AJ, Aagaard KM, Grove KL, Friedman JE. Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques. JCI Insight. 2016 Oct 06; 1(16):e86612. PMID: 27734025.
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    16. Thomsen HS. Are the increasing amounts of gadolinium in surface and tap water dangerous? Acta Radiol. 2017 Mar; 58(3):259-263. PMID: 27609906.
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    17. Zogby AM, Dayanidhi S, Chambers HG, Schenk S, Lieber RL. Skeletal muscle fiber-type specific succinate dehydrogenase activity in cerebral palsy. Muscle Nerve. 2017 01; 55(1):122-124. PMID: 27515237.
      View in: PubMed
    18. Gao MH, Giamouridis D, Lai NC, Walenta E, Paschoal VA, Kim YC, Miyanohara A, Guo T, Liao M, Liu L, Tan Z, Ciaraldi TP, Schenk S, Bhargava A, Oh DY, Hammond HK. One-time injection of AAV8 encoding urocortin 2 provides long-term resolution of insulin resistance. JCI Insight. 2016 Sep 22; 1(15):e88322. PMID: 27699250.
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    19. Gibbons MC, Sato EJ, Bachasson D, Cheng T, Azimi H, Schenk S, Engler AJ, Singh A, Ward SR. Muscle architectural changes after massive human rotator cuff tear. J Orthop Res. 2016 12; 34(12):2089-2095. PMID: 27061583.
      View in: PubMed
    20. Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL. Skeletal muscle action of estrogen receptor a is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Sci Transl Med. 2016 Apr 13; 8(334):334ra54. PMID: 27075628.
      View in: PubMed
    21. LaBarge SA, Migdal CW, Buckner EH, Okuno H, Gertsman I, Stocks B, Barshop BA, Nalbandian SR, Philp A, McCurdy CE, Schenk S. p300 is not required for metabolic adaptation to endurance exercise training. FASEB J. 2016 Apr; 30(4):1623-33. PMID: 26712218; PMCID: PMC4799503 [Available on 04/01/17].
    22. Cho Y, Hazen BC, Gandra PG, Ward SR, Schenk S, Russell AP, Kralli A. Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle. FASEB J. 2016 Feb; 30(2):674-87. PMID: 26481306.
      View in: PubMed
    23. Philp A, Schenk S, Perez-Schindler J, Hamilton DL, Breen L, Laverone E, Jeromson S, Phillips SM, Baar K. Rapamycin does not prevent increases in myofibrillar or mitochondrial protein synthesis following endurance exercise. J Physiol. 2015 Sep 15; 593(18):4275-84. PMID: 26227152; PMCID: PMC4594297.
    24. White AT, LaBarge SA, McCurdy CE, Schenk S. Knockout of STAT3 in skeletal muscle does not prevent high-fat diet-induced insulin resistance. Mol Metab. 2015 Aug; 4(8):569-75. PMID: 26266089; PMCID: PMC4529495.
    25. LaBarge S, Migdal C, Schenk S. Is acetylation a metabolic rheostat that regulates skeletal muscle insulin action? Mol Cells. 2015 Apr; 38(4):297-303. PMID: 25824547; PMCID: PMC4400303.
    26. Franck N, Maris M, Nalbandian S, Talukdar S, Schenk S, Hofmann HP, Bullough D, Osborn O. Knock-down of IL-1Ra in obese mice decreases liver inflammation and improves insulin sensitivity. PLoS One. 2014; 9(9):e107487. PMID: 25244011; PMCID: PMC4171490.
    27. Choo A, McCarthy M, Pichika R, Sato EJ, Lieber RL, Schenk S, Lane JG, Ward SR. Muscle gene expression patterns in human rotator cuff pathology. J Bone Joint Surg Am. 2014 Sep 17; 96(18):1558-65. PMID: 25232080; PMCID: PMC4159966.
    28. Newsom SA, Schenk S. Interaction between lipid availability,endurance exercise and insulin sensitivity. Med Sport Sci. 2014; 60:62-70. PMID: 25226801.
      View in: PubMed
    29. Philp A, Rowland T, Perez-Schindler J, Schenk S. Understanding the acetylome: translating targeted proteomics into meaningful physiology. Am J Physiol Cell Physiol. 2014 Nov 01; 307(9):C763-73. PMID: 25186010; PMCID: PMC4216940.
    30. White AT, Philp A, Fridolfsson HN, Schilling JM, Murphy AN, Hamilton DL, McCurdy CE, Patel HH, Schenk S. High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression. Am J Physiol Endocrinol Metab. 2014 Nov 01; 307(9):E764-72. PMID: 25159328; PMCID: PMC4216952.
    31. Lee YS, Kim JW, Osborne O, Oh DY, Sasik R, Schenk S, Chen A, Chung H, Murphy A, Watkins SM, Quehenberger O, Johnson RS, Olefsky JM. Increased adipocyte O2 consumption triggers HIF-1a, causing inflammation and insulin resistance in obesity. Cell. 2014 Jun 05; 157(6):1339-52. PMID: 24906151.
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    32. McGlory C, White A, Treins C, Drust B, Close GL, Maclaren DP, Campbell IT, Philp A, Schenk S, Morton JP, Hamilton DL. Application of the [?-32P] ATP kinase assay to study anabolic signaling in human skeletal muscle. J Appl Physiol (1985). 2014 Mar 01; 116(5):504-13. PMID: 24436296; PMCID: PMC4116398.
    33. Philp A, Schenk S. Unraveling the complexities of SIRT1-mediated mitochondrial regulation in skeletal muscle. Exerc Sport Sci Rev. 2013 Jul; 41(3):174-81. PMID: 23792490; PMCID: PMC3707796.
    34. Meyer GA, Schenk S, Lieber RL. Role of the cytoskeleton in muscle transcriptional responses to altered use. Physiol Genomics. 2013 Apr 16; 45(8):321-31. PMID: 23444318; PMCID: PMC3633430.
    35. Boon J, Hoy AJ, Stark R, Brown RD, Meex RC, Henstridge DC, Schenk S, Meikle PJ, Horowitz JF, Kingwell BA, Bruce CR, Watt MJ. Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance. Diabetes. 2013 Feb; 62(2):401-10. PMID: 23139352; PMCID: PMC3554351.
    36. Chao LC, Wroblewski K, Ilkayeva OR, Stevens RD, Bain J, Meyer GA, Schenk S, Martinez L, Vergnes L, Narkar VA, Drew BG, Hong C, Boyadjian R, Hevener AL, Evans RM, Reue K, Spencer MJ, Newgard CB, Tontonoz P. Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization. J Lipid Res. 2012 Dec; 53(12):2610-9. PMID: 23028113; PMCID: PMC3494265.
    37. McCurdy CE, Schenk S, Holliday MJ, Philp A, Houck JA, Patsouris D, MacLean PS, Majka SM, Klemm DJ, Friedman JE. Attenuated Pik3r1 expression prevents insulin resistance and adipose tissue macrophage accumulation in diet-induced obese mice. Diabetes. 2012 Oct; 61(10):2495-505. PMID: 22698915.
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    38. Osborn O, Oh DY, McNelis J, Sanchez-Alavez M, Talukdar S, Lu M, Li P, Thiede L, Morinaga H, Kim JJ, Heinrichsdorff J, Nalbandian S, Ofrecio JM, Scadeng M, Schenk S, Hadcock J, Bartfai T, Olefsky JM. G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice. J Clin Invest. 2012 Jul; 122(7):2444-53. PMID: 22653059; PMCID: PMC3386820.
    39. White AT, Schenk S. NAD(+)/NADH and skeletal muscle mitochondrial adaptations to exercise. Am J Physiol Endocrinol Metab. 2012 Aug 01; 303(3):E308-21. PMID: 22436696; PMCID: PMC3423123.
    40. Menzies KJ, Chabi B, Hood DA, Schenk S, Philp A, Philip A, Braga VA, Guimaraes DD. Commentaries on viewpoint: does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments? J Appl Physiol (1985). 2012 Mar; 112(5):929-30. PMID: 22383496.
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    41. Lieber R, Ward S, Frank L, Schenk S. New opportunities and novel paradigms to support neuromuscular research. Phys Med Rehabil Clin N Am. 2012 Feb; 23(1):95-105, xi. PMID: 22239877.
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    42. Schenk S, McCurdy CE, Philp A, Chen MZ, Holliday MJ, Bandyopadhyay GK, Osborn O, Baar K, Olefsky JM. Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. J Clin Invest. 2011 Nov; 121(11):4281-8. PMID: 21985785; PMCID: PMC3204844.
    43. Philp A, Belew MY, Evans A, Pham D, Sivia I, Chen A, Schenk S, Baar K. The PGC-1a-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes. Am J Physiol Regul Integr Comp Physiol. 2011 Oct; 301(4):R864-72. PMID: 21795630; PMCID: PMC3197342.
    44. Philp A, Chen A, Lan D, Meyer GA, Murphy AN, Knapp AE, Olfert IM, McCurdy CE, Marcotte GR, Hogan MC, Baar K, Schenk S. Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise. J Biol Chem. 2011 Sep 02; 286(35):30561-70. PMID: 21757760; PMCID: PMC3162416.
    45. Lu M, Li P, Pferdekamper J, Fan W, Saberi M, Schenk S, Olefsky JM. Inducible nitric oxide synthase deficiency in myeloid cells does not prevent diet-induced insulin resistance. Mol Endocrinol. 2010 Jul; 24(7):1413-22. PMID: 20444886; PMCID: PMC2903908.
    46. Lu M, Patsouris D, Li P, Flores-Riveros J, Frincke JM, Watkins S, Schenk S, Olefsky JM. A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats. Am J Physiol Endocrinol Metab. 2010 May; 298(5):E1036-48. PMID: 20159859; PMCID: PMC2867370.
    47. Newsom SA, Schenk S, Thomas KM, Harber MP, Knuth ND, Goldenberg N, Horowitz JF. Energy deficit after exercise augments lipid mobilization but does not contribute to the exercise-induced increase in insulin sensitivity. J Appl Physiol (1985). 2010 Mar; 108(3):554-60. PMID: 20044472; PMCID: PMC2838634.
    48. Yoshizaki T, Schenk S, Imamura T, Babendure JL, Sonoda N, Bae EJ, Oh DY, Lu M, Milne JC, Westphal C, Bandyopadhyay G, Olefsky JM. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab. 2010 Mar; 298(3):E419-28. PMID: 19996381; PMCID: PMC2838524.
    49. Saberi M, Woods NB, de Luca C, Schenk S, Lu JC, Bandyopadhyay G, Verma IM, Olefsky JM. Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab. 2009 Nov; 10(5):419-29. PMID: 19883619; PMCID: PMC2790319.
    50. Schenk S, Harber MP, Shrivastava CR, Burant CF, Horowitz JF. Improved insulin sensitivity after weight loss and exercise training is mediated by a reduction in plasma fatty acid mobilization, not enhanced oxidative capacity. J Physiol. 2009 Oct 15; 587(Pt 20):4949-61. PMID: 19723783; PMCID: PMC2770158.
    51. Gayen JR, Saberi M, Schenk S, Biswas N, Vaingankar SM, Cheung WW, Najjar SM, O'Connor DT, Bandyopadhyay G, Mahata SK. A novel pathway of insulin sensitivity in chromogranin A null mice: a crucial role for pancreastatin in glucose homeostasis. J Biol Chem. 2009 Oct 16; 284(42):28498-509. PMID: 19706599; PMCID: PMC2781393.
    52. Saberi M, Bjelica D, Schenk S, Imamura T, Bandyopadhyay G, Li P, Jadhar V, Vargeese C, Wang W, Bowman K, Zhang Y, Polisky B, Olefsky JM. Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes. Am J Physiol Endocrinol Metab. 2009 Nov; 297(5):E1137-46. PMID: 19706791.
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    53. Vu CB, Bemis JE, Disch JS, Ng PY, Nunes JJ, Milne JC, Carney DP, Lynch AV, Smith JJ, Lavu S, Lambert PD, Gagne DJ, Jirousek MR, Schenk S, Olefsky JM, Perni RB. Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators. J Med Chem. 2009 Mar 12; 52(5):1275-83. PMID: 19199480.
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    54. Yoshizaki T, Milne JC, Imamura T, Schenk S, Sonoda N, Babendure JL, Lu JC, Smith JJ, Jirousek MR, Olefsky JM. SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Mol Cell Biol. 2009 Mar; 29(5):1363-74. PMID: 19103747; PMCID: PMC2643824.
    55. Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates J, Olefsky J, Guarente L, Montminy M. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature. 2008 Nov 13; 456(7219):269-73. PMID: 18849969; PMCID: PMC2597669.
    56. Schenk S, Saberi M, Olefsky JM. Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest. 2008 Sep; 118(9):2992-3002. PMID: 18769626; PMCID: PMC2522344.
    57. Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29; 450(7170):712-6. PMID: 18046409; PMCID: PMC2753457.
    58. Schenk S, Horowitz JF. Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance. J Clin Invest. 2007 Jun; 117(6):1690-8. PMID: 17510709; PMCID: PMC1866251.
    59. Schenk S, Horowitz JF. Coimmunoprecipitation of FAT/CD36 and CPT I in skeletal muscle increases proportionally with fat oxidation after endurance exercise training. Am J Physiol Endocrinol Metab. 2006 Aug; 291(2):E254-60. PMID: 16670153.
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    60. Harber MP, Schenk S, Barkan AL, Horowitz JF. Alterations in carbohydrate metabolism in response to short-term dietary carbohydrate restriction. Am J Physiol Endocrinol Metab. 2005 Aug; 289(2):E306-12. PMID: 15797987.
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    61. Schenk S, Cook JN, Kaufman AE, Horowitz JF. Postexercise insulin sensitivity is not impaired after an overnight lipid infusion. Am J Physiol Endocrinol Metab. 2005 Mar; 288(3):E519-25. PMID: 15522993.
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    62. Zderic TW, Schenk S, Davidson CJ, Byerley LO, Coyle EF. Manipulation of dietary carbohydrate and muscle glycogen affects glucose uptake during exercise when fat oxidation is impaired by beta-adrenergic blockade. Am J Physiol Endocrinol Metab. 2004 Dec; 287(6):E1195-201. PMID: 15315908.
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    63. Zderic TW, Davidson CJ, Schenk S, Byerley LO, Coyle EF. High-fat diet elevates resting intramuscular triglyceride concentration and whole body lipolysis during exercise. Am J Physiol Endocrinol Metab. 2004 Feb; 286(2):E217-25. PMID: 14559721.
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