-
Sexually Distinct Multi-Omic Responses to Progressive Endurance Exercise Training in the Rat Lung - Findings from MoTrPAC. Am J Respir Cell Mol Biol. 2025 Oct 24.
Many GM, Sagendorf TJ, Mitchell H, Sanford JA, Cohen S, Misra R, Estevao I, Díaz Ludovico I, Gaul DA, Lindholm ME, Ushakumary MG, Pino J, Musi N, Nie J, Fernández FM, Ortlund EA, Esser KA, Bodine SC, Schenk S, Clair G, Adkins JN, MoTrPAC Study Group. PMID: 41134976.
View in:
PubMed Mentions:
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Markers of mitochondrial function and oxidative metabolism in skeletal muscle do not display intrinsic circadian regulation in female mice. Am J Physiol Endocrinol Metab. 2025 Dec 01; 329(6):E828-E838.
Fitzgerald LS, Reynoso Spurrier CS, Lau NJ, Melamed MD, Burnett LA, Meyer GA, Gui C, Hevener AL, Sanford JA, Schenk S. PMID: 41060722; PMCID: PMC12677914.
View in:
PubMed Mentions:
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Impacts of Reducing Sitting Time or Increasing Sit-to-Stand Transitions on Blood Pressure and Glucose Regulation in Postmenopausal Women: Three-Arm Randomized Controlled Trial. Circulation. 2025 Aug 26; 152(8):492-504.
Hartman SJ, LaCroix AZ, Sears DD, Natarajan L, Zablocki RW, Chen R, Patterson JS, Dillon L, Sallis JF, Schenk S, Dunstan DW, Owen N, Rosenberg DE. PMID: 40709462; PMCID: PMC12342652.
View in:
PubMed Mentions: Fields:
Translation:
Humans
-
Intrinsic Skeletal Muscle Function and Contraction-Stimulated Glucose Uptake Do Not Vary by Time-of-Day in Mice. Function (Oxf). 2024 Nov 20; 5(6).
Fitzgerald LS, Bremner SN, Ward SR, Cho Y, Schenk S. PMID: 39134511; PMCID: PMC11873798.
View in:
PubMed Mentions:
2 Fields:
Translation:
Animals
-
Murine nuclear tyrosyl-tRNA synthetase deficiency leads to fat storage deficiency and hearing loss. J Biol Chem. 2024 Oct; 300(10):107756.
Jones JA, Zhou J, Dong J, Huitron-Resendiz S, Boussaty E, Chavez E, Wei N, Dumitru CD, Morodomi Y, Kanaji T, Ryan AF, Friedman R, Zhou T, Kanaji S, Wortham M, Schenk S, Roberts AJ, Yang XL. PMID: 39260699; PMCID: PMC11470617.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
-
Physiological Adaptations to Progressive Endurance Exercise Training in Adult and Aged Rats: Insights from the Molecular Transducers of Physical Activity Consortium (MoTrPAC). Function (Oxf). 2024 Jul 11; 5(4).
Schenk S, Sagendorf TJ, Many GM, Lira AK, de Sousa LGO, Bae D, Cicha M, Kramer KS, Muehlbauer M, Hevener AL, Rector RS, Thyfault JP, Williams JP, Goodyear LJ, Esser KA, Newgard CB, Bodine SC, MoTrPAC Study Group
. PMID: 38984994; PMCID: PMC11245678.
View in:
PubMed Mentions:
12 Fields:
Translation:
Animals
-
Insights into posttranslational regulation of skeletal muscle contractile function by the acetyltransferases, p300 and CBP. J Appl Physiol (1985). 2024 Jun 01; 136(6):1559-1567.
Meyer GA, Ferey JLA, Sanford JA, Fitzgerald LS, Greenberg AE, Svensson K, Greenberg MJ, Schenk S. PMID: 38722753; PMCID: PMC11365544.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
-
The mitochondrial multi-omic response to exercise training across rat tissues. Cell Metab. 2024 Jun 04; 36(6):1411-1429.e10.
Amar D, Gay NR, Jimenez-Morales D, Jean Beltran PM, Ramaker ME, Raja AN, Zhao B, Sun Y, Marwaha S, Gaul DA, Hershman SG, Ferrasse A, Xia A, Lanza I, Fernández FM, Montgomery SB, Hevener AL, Ashley EA, Walsh MJ, Sparks LM, Burant CF, Rector RS, Thyfault J, Wheeler MT, Goodpaster BH, Coen PM, Schenk S, Bodine SC, Lindholm ME, MoTrPAC Study Group. PMID: 38701776; PMCID: PMC11152996.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue. Nat Metab. 2024 May; 6(5):963-979.
Many GM, Sanford JA, Sagendorf TJ, Hou Z, Nigro P, Whytock KL, Amar D, Caputo T, Gay NR, Gaul DA, Hirshman MF, Jimenez-Morales D, Lindholm ME, Muehlbauer MJ, Vamvini M, Bergman BC, Fernández FM, Goodyear LJ, Hevener AL, Ortlund EA, Sparks LM, Xia A, Adkins JN, Bodine SC, Newgard CB, Schenk S, MoTrPAC Study Group. PMID: 38693320; PMCID: PMC11132991.
View in:
PubMed Mentions:
18 Fields:
Translation:
Animals
-
Network model of skeletal muscle cell signalling predicts differential responses to endurance and resistance exercise training. Exp Physiol. 2024 Jun; 109(6):939-955.
Fowler A, Knaus KR, Khuu S, Khalilimeybodi A, Schenk S, Ward SR, Fry AC, Rangamani P, McCulloch AD. PMID: 38643471; PMCID: PMC11140181.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Insights into post-translational regulation of skeletal muscle contractile function by the acetyltransferases, p300 and CBP. bioRxiv. 2024 Feb 29.
Meyer GA, Ferey JLA, Sanford JA, Fitzgerald LS, Greenberg AE, Svensson K, Greenberg MJ, Schenk S. PMID: 38463996; PMCID: PMC10925228.
View in:
PubMed Mentions:
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The effect of tenotomy, neurotomy, and dual injury on mouse rotator cuff muscles: Consequences for the mouse as a preclinical model. J Orthop Res. 2024 06; 42(6):1170-1179.
Gibbons MC, Silldorff M, Okuno H, Esparza MC, Migdal C, Johnson S, Schenk S, Ward SR. PMID: 38245849.
View in:
PubMed Mentions: Fields:
Translation:
Animals
-
A Maternal Western-Style Diet Impairs Skeletal Muscle Lipid Metabolism in Adolescent Japanese Macaques. Diabetes. 2023 12 01; 72(12):1766-1780.
Greyslak KT, Hetrick B, Bergman BC, Dean TA, Wesolowski SR, Gannon M, Schenk S, Sullivan EL, Aagaard KM, Kievit P, Chicco AJ, Friedman JE, McCurdy CE. PMID: 37725952; PMCID: PMC10658061.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
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Paraspinal muscles in individuals undergoing surgery for lumbar spine pathology lack a myogenic response to an acute bout of resistance exercise. JOR Spine. 2024 Mar; 7(1):e1291.
Shahidi B, Anderson B, Ordaz A, Berry DB, Ruoss S, Zlomislic V, Allen RT, Garfin SR, Farshad M, Schenk S, Ward SR. PMID: 38222805; PMCID: PMC10782077.
View in:
PubMed Mentions:
3
-
Cancer-cell-secreted extracellular vesicles target p53 to impair mitochondrial function in muscle. EMBO Rep. 2023 09 06; 24(9):e56464.
Ruan X, Cao M, Yan W, Jones YZ, Gustafsson ÅB, Patel HH, Schenk S, Wang SE. PMID: 37439436; PMCID: PMC10481655.
View in:
PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
-
Paraspinal muscle gene expression across different aetiologies in individuals undergoing surgery for lumbar spine pathology. Eur Spine J. 2023 04; 32(4):1123-1131.
Ordaz A, Anderson B, Zlomislic V, Allen RT, Garfin SR, Schuepbach R, Farshad M, Schenk S, Ward SR, Shahidi B. PMID: 36740606; PMCID: PMC10448537.
View in:
PubMed Mentions:
1 Fields:
Translation:
Humans
-
Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue. bioRxiv. 2023 Feb 04.
Many GM, Sanford JA, Sagendorf TJ, Hou Z, Nigro P, Whytock K, Amar D, Caputo T, Gay NR, Gaul DA, Hirshman M, Jimenez-Morales D, Lindholm ME, Muehlbauer MJ, Vamvini M, Bergman B, Fern Ndez FM, Goodyear LJ, Ortlund EA, Sparks LM, Xia A, Adkins JN, Bodine SC, Newgard CB, Schenk S, MoTrPAC Study Group. PMID: 36778330; PMCID: PMC9915732.
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PubMed Mentions:
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The Association of Metabolic Syndrome and Obesity With Clinical Hip Osteoarthritis in the Study of Osteoporotic Fractures and the Osteoporotic Fractures in Men Study Cohorts. ACR Open Rheumatol. 2023 Mar; 5(3):115-123.
Cheng KY, Strotmeyer ES, Kado DM, Schousboe JT, Schenk S, Nevitt M, Lane NE, Hughes-Austin JM. PMID: 36694301; PMCID: PMC10010487.
View in:
PubMed Mentions:
4
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The mitochondrial multi-omic response to exercise training across tissues. bioRxiv. 2023 Jan 13.
Amar D, Gay NR, Jimenez-Morales D, Beltran PMJ, Ramaker ME, Raja AN, Zhao B, Sun Y, Marwaha S, Gaul D, Hershman SG, Xia A, Lanza I, Fernandez FM, Montgomery SB, Hevener AL, Ashley EA, Walsh MJ, Sparks LM, Burant CF, Rector RS, Thyfault J, Wheeler MT, Goodpaster BH, Coen PM, Schenk S, Bodine SC, Lindholm ME, MoTrPAC Study Group. PMID: 36711881; PMCID: PMC9882193.
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PubMed Mentions:
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Paraspinal Muscle Health is Related to Fibrogenic, Adipogenic, and Myogenic Gene Expression in Patients with Lumbar Spine Pathology. BMC Musculoskelet Disord. 2022 Jun 24; 23(1):608.
Anderson B, Ordaz A, Zlomislic V, Allen RT, Garfin SR, Schuepbach R, Farshad M, Schenk S, Ward SR, Shahidi B. PMID: 35739523; PMCID: PMC9229083.
View in:
PubMed Mentions:
6 Fields:
Translation:
Humans
-
Skeletal muscle gene expression in older adults with type 2 diabetes mellitus undergoing calorie-restricted diet and recreational sports training - a randomized clinical trial. Exp Gerontol. 2022 07; 164:111831.
da Silva Soares DB, Shinjo SK, Santos AS, de Cassia Rosa de Jesus J, Schenk S, de Castro GS, Zanoteli E, Krustrup P, da Silva MER, de Sousa MV. PMID: 35525396.
View in:
PubMed Mentions:
7 Fields:
Translation:
Humans
-
Cancer-cell-secreted miR-122 suppresses O-GlcNAcylation to promote skeletal muscle proteolysis. Nat Cell Biol. 2022 05; 24(5):793-804.
Yan W, Cao M, Ruan X, Jiang L, Lee S, Lemanek A, Ghassemian M, Pizzo DP, Wan Y, Qiao Y, Chin AR, Duggan E, Wang D, Nolan JP, Esko JD, Schenk S, Wang SE. PMID: 35469018; PMCID: PMC9107513.
View in:
PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes. JCI Insight. 2022 01 11; 7(1).
Martins VF, LaBarge SA, Stanley A, Svensson K, Hung CW, Keinan O, Ciaraldi TP, Banoian D, Park JE, Ha C, Hetrick B, Meyer GA, Philp A, David LL, Henry RR, Aslan JE, Saltiel AR, McCurdy CE, Schenk S. PMID: 34813504; PMCID: PMC8765050.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
-
Interrupting Sitting Time in Postmenopausal Women: Protocol for the Rise for Health Randomized Controlled Trial. JMIR Res Protoc. 2021 May 13; 10(5):e28684.
Hartman SJ, Dillon LW, LaCroix AZ, Natarajan L, Sears DD, Owen N, Dunstan DW, Sallis JF, Schenk S, Allison M, Takemoto M, Herweck AM, Nguyen B, Rosenberg DE. PMID: 33983131; PMCID: PMC8160808.
View in:
PubMed Mentions:
2 Fields:
-
Sirtuin 1 is not required for contraction-stimulated glucose uptake in mouse skeletal muscle. J Appl Physiol (1985). 2021 06 01; 130(6):1893-1902.
Kang JH, Park JE, Dagoon J, Masson SWC, Merry TL, Bremner SN, Dent JR, Schenk S. PMID: 33886385; PMCID: PMC8285607.
View in:
PubMed Mentions:
5 Fields:
Translation:
Animals
-
Quantifying the Effects of Aging on Morphological and Cellular Properties of Human Female Pelvic Floor Muscles. Ann Biomed Eng. 2021 Aug; 49(8):1836-1847.
Rieger M, Duran P, Cook M, Schenk S, Shah M, Jacobs M, Christman K, Kado DM, Alperin M. PMID: 33683527; PMCID: PMC8376748.
View in:
PubMed Mentions:
6 Fields:
Translation:
Humans
-
Analgesic Medication Use During Exercise-Based Rehabilitation in Individuals With Low Back Pain: A Call to Action. Phys Ther. 2021 03 03; 101(3).
Shahidi B, Schenk S, Raiszadeh K. PMID: 33454784; PMCID: PMC8005293.
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PubMed Mentions: Fields:
Translation:
Humans
-
Surgical site peptidylarginine deaminase 4 (PAD4), a biomarker of NETosis, correlates with insulin resistance in total joint arthroplasty patients: A preliminary report. PLoS One. 2021; 16(1):e0245594.
Martins VF, Dobson CR, Begur M, Parekh J, Ball ST, Gonzalez F, Hughes-Austin JM, Schenk S. PMID: 33481860; PMCID: PMC7822240.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
-
Skeletal muscle maximal mitochondrial activity in ambulatory children with cerebral palsy. Dev Med Child Neurol. 2021 10; 63(10):1194-1203.
Dayanidhi S, Buckner EH, Redmond RS, Chambers HG, Schenk S, Lieber RL. PMID: 33393083.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
-
View in:
PubMed Mentions:
6
-
Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise. Cell. 2020 06 25; 181(7):1464-1474.
Sanford JA, Nogiec CD, Lindholm ME, Adkins JN, Amar D, Dasari S, Drugan JK, Fernández FM, Radom-Aizik S, Schenk S, Snyder MP, Tracy RP, Vanderboom P, Trappe S, Walsh MJ, Molecular Transducers of Physical Activity Consortium. PMID: 32589957; PMCID: PMC8800485.
View in:
PubMed Mentions:
141 Fields:
Translation:
HumansAnimals
-
Maternal Obesity and Western-Style Diet Impair Fetal and Juvenile Offspring Skeletal Muscle Insulin-Stimulated Glucose Transport in Nonhuman Primates. Diabetes. 2020 07; 69(7):1389-1400.
Campodonico-Burnett W, Hetrick B, Wesolowski SR, Schenk S, Takahashi DL, Dean TA, Sullivan EL, Kievit P, Gannon M, Aagaard K, Friedman JE, McCurdy CE. PMID: 32354857; PMCID: PMC7306120.
View in:
PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
-
p300 and cAMP response element-binding protein-binding protein in skeletal muscle homeostasis, contractile function, and survival. J Cachexia Sarcopenia Muscle. 2020 04; 11(2):464-477.
Svensson K, LaBarge SA, Sathe A, Martins VF, Tahvilian S, Cunliffe JM, Sasik R, Mahata SK, Meyer GA, Philp A, David LL, Ward SR, McCurdy CE, Aslan JE, Schenk S. PMID: 31898871; PMCID: PMC7113519.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansAnimals
-
Combined overexpression of SIRT1 and knockout of GCN5 in adult skeletal muscle does not affect glucose homeostasis or exercise performance in mice. Am J Physiol Endocrinol Metab. 2020 02 01; 318(2):E145-E151.
Svensson K, Tahvilian S, Martins VF, Dent JR, Lemanek A, Barooni N, Greyslak K, McCurdy CE, Schenk S. PMID: 31794263; PMCID: PMC7052578.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
-
Skeletal muscle mitochondrial function and exercise capacity are not impaired in mice with knockout of STAT3. J Appl Physiol (1985). 2019 10 01; 127(4):1117-1127.
Dent JR, Hetrick B, Tahvilian S, Sathe A, Greyslak K, LaBarge SA, Svensson K, McCurdy CE, Schenk S. PMID: 31513449; PMCID: PMC6850983.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
Acute inhibition of protein deacetylases does not impact skeletal muscle insulin action. Am J Physiol Cell Physiol. 2019 11 01; 317(5):C964-C968.
Martins VF, Begur M, Lakkaraju S, Svensson K, Park J, Hetrick B, McCurdy CE, Schenk S. PMID: 31461343; PMCID: PMC6879879.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity. Am J Physiol Endocrinol Metab. 2019 06 01; 316(6):E1024-E1035.
Martins VF, Dent JR, Svensson K, Tahvilian S, Begur M, Lakkaraju S, Buckner EH, LaBarge SA, Hetrick B, McCurdy CE, Schenk S. PMID: 30888860; PMCID: PMC6620570.
View in:
PubMed Mentions:
7 Fields:
Translation:
Animals
-
Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution. Proc Biol Sci. 2018 09 12; 285(1886).
Okerblom J, Fletes W, Patel HH, Schenk S, Varki A, Breen EC. PMID: 30209232; PMCID: PMC6158528.
View in:
PubMed Mentions:
14 Fields:
Translation:
Animals
-
Defining the contribution of skeletal muscle pyruvate dehydrogenase α1 to exercise performance and insulin action. Am J Physiol Endocrinol Metab. 2018 11 01; 315(5):E1034-E1045.
Svensson K, Dent JR, Tahvilian S, Martins VF, Sathe A, Ochala J, Patel MS, Schenk S. PMID: 30153068; PMCID: PMC6293170.
View in:
PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
-
Calorie Restriction-Induced Increase in Skeletal Muscle Insulin Sensitivity Is Not Prevented by Overexpression of the p55α Subunit of Phosphoinositide 3-Kinase. Front Physiol. 2018; 9:789.
Martins VF, Tahvilian S, Kang JH, Svensson K, Hetrick B, Chick WS, Schenk S, McCurdy CE. PMID: 29997524; PMCID: PMC6030672.
View in:
PubMed Mentions:
8
-
Cysteine- and glycine-rich protein 3 regulates glucose homeostasis in skeletal muscle. Am J Physiol Endocrinol Metab. 2018 08 01; 315(2):E267-E278.
Hernandez-Carretero A, Weber N, LaBarge SA, Peterka V, Doan NYT, Schenk S, Osborn O. PMID: 29634311; PMCID: PMC6139493.
View in:
PubMed Mentions:
4 Fields:
Translation:
Animals
-
SIRT1 regulates nuclear number and domain size in skeletal muscle fibers. J Cell Physiol. 2018 09; 233(9):7157-7163.
Ross JA, Levy Y, Svensson K, Philp A, Schenk S, Ochala J. PMID: 29574748; PMCID: PMC5993587.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
-
Heterogeneous muscle gene expression patterns in patients with massive rotator cuff tears. PLoS One. 2018; 13(1):e0190439.
Gibbons MC, Fisch KM, Pichika R, Cheng T, Engler AJ, Schenk S, Lane JG, Singh A, Ward SR. PMID: 29293645; PMCID: PMC5749784.
View in:
PubMed Mentions:
6 Fields:
Translation:
Humans
-
Acute glucoregulatory and vascular outcomes of three strategies for interrupting prolonged sitting time in postmenopausal women: A pilot, laboratory-based, randomized, controlled, 4-condition, 4-period crossover trial. PLoS One. 2017; 12(11):e0188544.
Kerr J, Crist K, Vital DG, Dillon L, Aden SA, Trivedi M, Castellanos LR, Godbole S, Li H, Allison MA, Khemlina GL, Takemoto ML, Schenk S, Sallis JF, Grace M, Dunstan DW, Natarajan L, LaCroix AZ, Sears DD. PMID: 29190761; PMCID: PMC5708739.
View in:
PubMed Mentions:
21 Fields:
Translation:
Humans
-
Exercise and high-fat feeding remodel transcript-metabolite interactive networks in mouse skeletal muscle. Sci Rep. 2017 10 18; 7(1):13485.
Pérez-Schindler J, Kanhere A, Edwards L, Allwood JW, Dunn WB, Schenk S, Philp A. PMID: 29044196; PMCID: PMC5647435.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
-
Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation. Mol Metab. 2017 12; 6(12):1574-1584.
Dent JR, Martins VF, Svensson K, LaBarge SA, Schlenk NC, Esparza MC, Buckner EH, Meyer GA, Hamilton DL, Schenk S, Philp A. PMID: 29111103; PMCID: PMC5699915.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
-
Overload-mediated skeletal muscle hypertrophy is not impaired by loss of myofiber STAT3. Am J Physiol Cell Physiol. 2017 Sep 01; 313(3):C257-C261.
Pérez-Schindler J, Esparza MC, McKendry J, Breen L, Philp A, Schenk S. PMID: 28659288; PMCID: PMC5625092.
View in:
PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
-
Temporal overexpression of SIRT1 in skeletal muscle of adult mice does not improve insulin sensitivity or markers of mitochondrial biogenesis. Acta Physiol (Oxf). 2017 Nov; 221(3):193-203.
Svensson K, LaBarge SA, Martins VF, Schenk S. PMID: 28544355; PMCID: PMC5641221.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
-
Dried Plum Ingestion Increases the Osteoblastogenic Capacity of Human Serum. J Med Food. 2017 Jul; 20(7):653-658.
Delgado Cuenca P, Almaiman L, Schenk S, Kern M, Hooshmand S. PMID: 28445075.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat Chem Biol. 2017 06; 13(6):624-632.
Stanford SM, Aleshin AE, Zhang V, Ardecky RJ, Hedrick MP, Zou J, Ganji SR, Bliss MR, Yamamoto F, Bobkov AA, Kiselar J, Liu Y, Cadwell GW, Khare S, Yu J, Barquilla A, Chung TDY, Mustelin T, Schenk S, Bankston LA, Liddington RC, Pinkerton AB, Bottini N. PMID: 28346406; PMCID: PMC5435566.
View in:
PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
-
Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK. EBioMedicine. 2017 Apr; 18:128-138.
Park SJ, Ahmad F, Um JH, Brown AL, Xu X, Kang H, Ke H, Feng X, Ryall J, Philp A, Schenk S, Kim MK, Sartorelli V, Chung JH. PMID: 28396013; PMCID: PMC5405165.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
-
mTOR regulates peripheral nerve response to tensile strain. J Neurophysiol. 2017 05 01; 117(5):2075-2084.
Love JM, Bober BG, Orozco E, White AT, Bremner SN, Lovering RM, Schenk S, Shah SB. PMID: 28250148; PMCID: PMC5434482.
View in:
PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
-
Histological Evidence of Muscle Degeneration in Advanced Human Rotator Cuff Disease. J Bone Joint Surg Am. 2017 Feb 01; 99(3):190-199.
Gibbons MC, Singh A, Anakwenze O, Cheng T, Pomerantz M, Schenk S, Engler AJ, Ward SR. PMID: 28145949; PMCID: PMC5395080.
View in:
PubMed Mentions:
52 Fields:
Translation:
Humans
-
Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques. JCI Insight. 2016 Oct 06; 1(16):e86612.
McCurdy CE, Schenk S, Hetrick B, Houck J, Drew BG, Kaye S, Lashbrook M, Bergman BC, Takahashi DL, Dean TA, Nemkov T, Gertsman I, Hansen KC, Philp A, Hevener AL, Chicco AJ, Aagaard KM, Grove KL, Friedman JE. PMID: 27734025; PMCID: PMC5053156.
View in:
PubMed Mentions:
53 Fields:
Translation:
AnimalsCells
-
Skeletal muscle fiber-type specific succinate dehydrogenase activity in cerebral palsy. Muscle Nerve. 2017 01; 55(1):122-124.
Zogby AM, Dayanidhi S, Chambers HG, Schenk S, Lieber RL. PMID: 27515237; PMCID: PMC5173443.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCells
-
One-time injection of AAV8 encoding urocortin 2 provides long-term resolution of insulin resistance. JCI Insight. 2016 09 22; 1(15):e88322.
Gao MH, Giamouridis D, Lai NC, Walenta E, Paschoal VA, Kim YC, Miyanohara A, Guo T, Liao M, Liu L, Tan Z, Ciaraldi TP, Schenk S, Bhargava A, Oh DY, Hammond HK. PMID: 27699250; PMCID: PMC5033760.
View in:
PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
-
Muscle architectural changes after massive human rotator cuff tear. J Orthop Res. 2016 12; 34(12):2089-2095.
Gibbons MC, Sato EJ, Bachasson D, Cheng T, Azimi H, Schenk S, Engler AJ, Singh A, Ward SR. PMID: 27061583; PMCID: PMC5423410.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
-
Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Sci Transl Med. 2016 Apr 13; 8(334):334ra54.
Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL. PMID: 27075628; PMCID: PMC4934679.
View in:
PubMed Mentions:
144 Fields:
Translation:
HumansAnimalsCells
-
p300 is not required for metabolic adaptation to endurance exercise training. FASEB J. 2016 Apr; 30(4):1623-33.
LaBarge SA, Migdal CW, Buckner EH, Okuno H, Gertsman I, Stocks B, Barshop BA, Nalbandian SR, Philp A, McCurdy CE, Schenk S. PMID: 26712218; PMCID: PMC4799503.
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PubMed Mentions:
19 Fields:
Translation:
Animals
-
Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle. FASEB J. 2016 Feb; 30(2):674-87.
Cho Y, Hazen BC, Gandra PG, Ward SR, Schenk S, Russell AP, Kralli A. PMID: 26481306; PMCID: PMC4714556.
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PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
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Rapamycin does not prevent increases in myofibrillar or mitochondrial protein synthesis following endurance exercise. J Physiol. 2015 Sep 15; 593(18):4275-84.
Philp A, Schenk S, Perez-Schindler J, Hamilton DL, Breen L, Laverone E, Jeromson S, Phillips SM, Baar K. PMID: 26227152; PMCID: PMC4594297.
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PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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Knockout of STAT3 in skeletal muscle does not prevent high-fat diet-induced insulin resistance. Mol Metab. 2015 Aug; 4(8):569-75.
White AT, LaBarge SA, McCurdy CE, Schenk S. PMID: 26266089; PMCID: PMC4529495.
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PubMed Mentions:
21 Fields:
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Is acetylation a metabolic rheostat that regulates skeletal muscle insulin action? Mol Cells. 2015 Apr; 38(4):297-303.
LaBarge S, Migdal C, Schenk S. PMID: 25824547; PMCID: PMC4400303.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Knock-down of IL-1Ra in obese mice decreases liver inflammation and improves insulin sensitivity. PLoS One. 2014; 9(9):e107487.
Franck N, Maris M, Nalbandian S, Talukdar S, Schenk S, Hofmann HP, Bullough D, Osborn O. PMID: 25244011; PMCID: PMC4171490.
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PubMed Mentions:
9 Fields:
Translation:
Animals
-
Muscle gene expression patterns in human rotator cuff pathology. J Bone Joint Surg Am. 2014 Sep 17; 96(18):1558-65.
Choo A, McCarthy M, Pichika R, Sato EJ, Lieber RL, Schenk S, Lane JG, Ward SR. PMID: 25232080; PMCID: PMC4159966.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Interaction between lipid availability,endurance exercise and insulin sensitivity. Med Sport Sci. 2014; 60:62-70.
Newsom SA, Schenk S. PMID: 25226801.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Understanding the acetylome: translating targeted proteomics into meaningful physiology. Am J Physiol Cell Physiol. 2014 Nov 01; 307(9):C763-73.
Philp A, Rowland T, Perez-Schindler J, Schenk S. PMID: 25186010; PMCID: PMC4216940.
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PubMed Mentions:
25 Fields:
Translation:
HumansCells
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High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression. Am J Physiol Endocrinol Metab. 2014 Nov 01; 307(9):E764-72.
White AT, Philp A, Fridolfsson HN, Schilling JM, Murphy AN, Hamilton DL, McCurdy CE, Patel HH, Schenk S. PMID: 25159328; PMCID: PMC4216952.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity. Cell. 2014 Jun 05; 157(6):1339-1352.
Lee YS, Kim JW, Osborne O, Oh DY, Sasik R, Schenk S, Chen A, Chung H, Murphy A, Watkins SM, Quehenberger O, Johnson RS, Olefsky JM. PMID: 24906151; PMCID: PMC4114226.
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PubMed Mentions:
316 Fields:
Translation:
AnimalsCells
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Application of the [γ-32P] ATP kinase assay to study anabolic signaling in human skeletal muscle. J Appl Physiol (1985). 2014 Mar 01; 116(5):504-13.
McGlory C, White A, Treins C, Drust B, Close GL, Maclaren DP, Campbell IT, Philp A, Schenk S, Morton JP, Hamilton DL. PMID: 24436296; PMCID: PMC4116398.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Unraveling the complexities of SIRT1-mediated mitochondrial regulation in skeletal muscle. Exerc Sport Sci Rev. 2013 Jul; 41(3):174-81.
Philp A, Schenk S. PMID: 23792490; PMCID: PMC3707796.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice. Diabetologia. 2013 Jul; 56(7):1629-37.
White AT, McCurdy CE, Philp A, Hamilton DL, Johnson CD, Schenk S. PMID: 23604553; PMCID: PMC3703320.
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PubMed Mentions:
29 Fields:
Translation:
Animals
-
Role of the cytoskeleton in muscle transcriptional responses to altered use. Physiol Genomics. 2013 Apr 16; 45(8):321-31.
Meyer GA, Schenk S, Lieber RL. PMID: 23444318; PMCID: PMC3633430.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance. Diabetes. 2013 Feb; 62(2):401-10.
Boon J, Hoy AJ, Stark R, Brown RD, Meex RC, Henstridge DC, Schenk S, Meikle PJ, Horowitz JF, Kingwell BA, Bruce CR, Watt MJ. PMID: 23139352; PMCID: PMC3554351.
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PubMed Mentions:
157 Fields:
Translation:
HumansAnimalsCells
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Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization. J Lipid Res. 2012 Dec; 53(12):2610-9.
Chao LC, Wroblewski K, Ilkayeva OR, Stevens RD, Bain J, Meyer GA, Schenk S, Martinez L, Vergnes L, Narkar VA, Drew BG, Hong C, Boyadjian R, Hevener AL, Evans RM, Reue K, Spencer MJ, Newgard CB, Tontonoz P. PMID: 23028113; PMCID: PMC3494265.
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PubMed Mentions:
47 Fields:
Translation:
AnimalsCells
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Attenuated Pik3r1 expression prevents insulin resistance and adipose tissue macrophage accumulation in diet-induced obese mice. Diabetes. 2012 Oct; 61(10):2495-505.
McCurdy CE, Schenk S, Holliday MJ, Philp A, Houck JA, Patsouris D, MacLean PS, Majka SM, Klemm DJ, Friedman JE. PMID: 22698915; PMCID: PMC3447911.
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PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice. J Clin Invest. 2012 Jul; 122(7):2444-53.
Osborn O, Oh DY, McNelis J, Sanchez-Alavez M, Talukdar S, Lu M, Li P, Thiede L, Morinaga H, Kim JJ, Heinrichsdorff J, Nalbandian S, Ofrecio JM, Scadeng M, Schenk S, Hadcock J, Bartfai T, Olefsky JM. PMID: 22653059; PMCID: PMC3386820.
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PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
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NAD(+)/NADH and skeletal muscle mitochondrial adaptations to exercise. Am J Physiol Endocrinol Metab. 2012 Aug 01; 303(3):E308-21.
White AT, Schenk S. PMID: 22436696; PMCID: PMC3423123.
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PubMed Mentions:
104 Fields:
Translation:
HumansAnimalsCells
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Commentaries on viewpoint: does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments? J Appl Physiol (1985). 2012 Mar; 112(5):929-30.
Menzies KJ, Chabi B, Hood DA, Schenk S, Philp A, Philip A, Braga VA, Guimaraes DD. PMID: 22383496.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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New opportunities and novel paradigms to support neuromuscular research. Phys Med Rehabil Clin N Am. 2012 Feb; 23(1):95-105, xi.
Lieber R, Ward S, Frank L, Schenk S. PMID: 22239877.
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PubMed Mentions: Fields:
Translation:
Humans
-
Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. J Clin Invest. 2011 Nov; 121(11):4281-8.
Schenk S, McCurdy CE, Philp A, Chen MZ, Holliday MJ, Bandyopadhyay GK, Osborn O, Baar K, Olefsky JM. PMID: 21985785; PMCID: PMC3204844.
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PubMed Mentions:
116 Fields:
Translation:
AnimalsCells
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The PGC-1α-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes. Am J Physiol Regul Integr Comp Physiol. 2011 Oct; 301(4):R864-72.
Philp A, Belew MY, Evans A, Pham D, Sivia I, Chen A, Schenk S, Baar K. PMID: 21795630; PMCID: PMC3197342.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise. J Biol Chem. 2011 Sep 02; 286(35):30561-30570.
Philp A, Chen A, Lan D, Meyer GA, Murphy AN, Knapp AE, Olfert IM, McCurdy CE, Marcotte GR, Hogan MC, Baar K, Schenk S. PMID: 21757760; PMCID: PMC3162416.
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PubMed Mentions:
101 Fields:
Translation:
AnimalsCells
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High fatty acid availability after exercise alters the regulation of muscle lipid metabolism. Metabolism. 2011 Jun; 60(6):852-9.
Newsom SA, Schenk S, Li M, Everett AC, Horowitz JF. PMID: 20870251; PMCID: PMC3011035.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Inducible nitric oxide synthase deficiency in myeloid cells does not prevent diet-induced insulin resistance. Mol Endocrinol. 2010 Jul; 24(7):1413-22.
Lu M, Li P, Pferdekamper J, Fan W, Saberi M, Schenk S, Olefsky JM. PMID: 20444886; PMCID: PMC2903908.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats. Am J Physiol Endocrinol Metab. 2010 May; 298(5):E1036-48.
Lu M, Patsouris D, Li P, Flores-Riveros J, Frincke JM, Watkins S, Schenk S, Olefsky JM. PMID: 20159859; PMCID: PMC2867370.
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Energy deficit after exercise augments lipid mobilization but does not contribute to the exercise-induced increase in insulin sensitivity. J Appl Physiol (1985). 2010 Mar; 108(3):554-60.
Newsom SA, Schenk S, Thomas KM, Harber MP, Knuth ND, Goldenberg N, Horowitz JF. PMID: 20044472; PMCID: PMC2838634.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
-
SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab. 2010 Mar; 298(3):E419-28.
Yoshizaki T, Schenk S, Imamura T, Babendure JL, Sonoda N, Bae EJ, Oh DY, Lu M, Milne JC, Westphal C, Bandyopadhyay G, Olefsky JM. PMID: 19996381; PMCID: PMC2838524.
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PubMed Mentions:
218 Fields:
Translation:
AnimalsCells
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Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab. 2009 Nov; 10(5):419-29.
Saberi M, Woods NB, de Luca C, Schenk S, Lu JC, Bandyopadhyay G, Verma IM, Olefsky JM. PMID: 19883619; PMCID: PMC2790319.
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PubMed Mentions:
239 Fields:
Translation:
AnimalsCells
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Improved insulin sensitivity after weight loss and exercise training is mediated by a reduction in plasma fatty acid mobilization, not enhanced oxidative capacity. J Physiol. 2009 Oct 15; 587(Pt 20):4949-61.
Schenk S, Harber MP, Shrivastava CR, Burant CF, Horowitz JF. PMID: 19723783; PMCID: PMC2770158.
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PubMed Mentions:
55 Fields:
Translation:
HumansCells
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A novel pathway of insulin sensitivity in chromogranin A null mice: a crucial role for pancreastatin in glucose homeostasis. J Biol Chem. 2009 Oct 16; 284(42):28498-509.
Gayen JR, Saberi M, Schenk S, Biswas N, Vaingankar SM, Cheung WW, Najjar SM, O'Connor DT, Bandyopadhyay G, Mahata SK. PMID: 19706599; PMCID: PMC2781393.
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PubMed Mentions:
49 Fields:
Translation:
AnimalsCells
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Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes. Am J Physiol Endocrinol Metab. 2009 Nov; 297(5):E1137-46.
Saberi M, Bjelica D, Schenk S, Imamura T, Bandyopadhyay G, Li P, Jadhar V, Vargeese C, Wang W, Bowman K, Zhang Y, Polisky B, Olefsky JM. PMID: 19706791; PMCID: PMC2781351.
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PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
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Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators. J Med Chem. 2009 Mar 12; 52(5):1275-83.
Vu CB, Bemis JE, Disch JS, Ng PY, Nunes JJ, Milne JC, Carney DP, Lynch AV, Smith JJ, Lavu S, Lambert PD, Gagne DJ, Jirousek MR, Schenk S, Olefsky JM, Perni RB. PMID: 19199480.
View in:
PubMed Mentions:
26 Fields:
Translation:
Animals
-
SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Mol Cell Biol. 2009 Mar; 29(5):1363-74.
Yoshizaki T, Milne JC, Imamura T, Schenk S, Sonoda N, Babendure JL, Lu JC, Smith JJ, Jirousek MR, Olefsky JM. PMID: 19103747; PMCID: PMC2643824.
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PubMed Mentions:
208 Fields:
Translation:
AnimalsCells
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A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature. 2008 Nov 13; 456(7219):269-73.
Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates J, Olefsky J, Guarente L, Montminy M. PMID: 18849969; PMCID: PMC2597669.
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PubMed Mentions:
307 Fields:
Translation:
HumansAnimalsCells
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Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest. 2008 Sep; 118(9):2992-3002.
Schenk S, Saberi M, Olefsky JM. PMID: 18769626; PMCID: PMC2522344.
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PubMed Mentions:
497 Fields:
Translation:
HumansAnimalsCells
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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29; 450(7170):712-6.
Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH. PMID: 18046409; PMCID: PMC2753457.
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PubMed Mentions:
781 Fields:
Translation:
HumansAnimalsCells
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Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance. J Clin Invest. 2007 Jun; 117(6):1690-8.
Schenk S, Horowitz JF. PMID: 17510709; PMCID: PMC1866251.
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PubMed Mentions:
180 Fields:
Translation:
HumansCells
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Coimmunoprecipitation of FAT/CD36 and CPT I in skeletal muscle increases proportionally with fat oxidation after endurance exercise training. Am J Physiol Endocrinol Metab. 2006 Aug; 291(2):E254-60.
Schenk S, Horowitz JF. PMID: 16670153.
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PubMed Mentions:
46 Fields:
Translation:
HumansCells
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Effects of dietary carbohydrate restriction with high protein intake on protein metabolism and the somatotropic axis. J Clin Endocrinol Metab. 2005 Sep; 90(9):5175-81.
Harber MP, Schenk S, Barkan AL, Horowitz JF. PMID: 15972575.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Alterations in carbohydrate metabolism in response to short-term dietary carbohydrate restriction. Am J Physiol Endocrinol Metab. 2005 Aug; 289(2):E306-12.
Harber MP, Schenk S, Barkan AL, Horowitz JF. PMID: 15797987.
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PubMed Mentions:
18 Fields:
Translation:
HumansCellsCTClinical Trials
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Postexercise insulin sensitivity is not impaired after an overnight lipid infusion. Am J Physiol Endocrinol Metab. 2005 Mar; 288(3):E519-25.
Schenk S, Cook JN, Kaufman AE, Horowitz JF. PMID: 15522993.
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PubMed Mentions:
21 Fields:
Translation:
HumansCTClinical Trials
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Manipulation of dietary carbohydrate and muscle glycogen affects glucose uptake during exercise when fat oxidation is impaired by beta-adrenergic blockade. Am J Physiol Endocrinol Metab. 2004 Dec; 287(6):E1195-201.
Zderic TW, Schenk S, Davidson CJ, Byerley LO, Coyle EF. PMID: 15315908.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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High-fat diet elevates resting intramuscular triglyceride concentration and whole body lipolysis during exercise. Am J Physiol Endocrinol Metab. 2004 Feb; 286(2):E217-25.
Zderic TW, Davidson CJ, Schenk S, Byerley LO, Coyle EF. PMID: 14559721.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
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Different glycemic indexes of breakfast cereals are not due to glucose entry into blood but to glucose removal by tissue. Am J Clin Nutr. 2003 Oct; 78(4):742-8.
Schenk S, Davidson CJ, Zderic TW, Byerley LO, Coyle EF. PMID: 14522732.