Karen Mestan

Title(s)Associate Physician Diplomate, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
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    Cord Blood Adductomics in Bronchopulmonary Dysplasia
    NIH R21HD100831Dec 10, 2019 - Nov 30, 2021
    Role: Principal Investigator
    The Role of Placental Maternal Vascular Underperfusion in Neonatal Pulmonary Hypertension
    NIH R01HL139798Feb 15, 2018 - Jan 31, 2023
    Role: Principal Investigator
    Oxidant Stress and Gene Polymorphisms in Bronchopulmonary Dysplasia
    NIH K23HL093302Apr 1, 2010 - Jan 31, 2015
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Umbilical cord miRNAs to predict neonatal early onset sepsis. PLoS One. 2021; 16(5):e0249548. Ernst LM, Mithal LB, Mestan K, Wang V, Mangold KA, Freedman A, Das S. PMID: 33961620.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Understanding Racial Disparities of Preterm Birth Through the Placenta. Clin Ther. 2021 02; 43(2):287-296. Matoba N, Mestan KK, Collins JW. PMID: 33483135.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Placental vascular maldevelopment, intrauterine growth restriction, and pulmonary hypertension. Pulm Circ. 2020 Oct-Dec; 10(4):2045894020970056. Mathias M, Bitar M, Aldulescu M, Birkett R, Perez M, Mestan K. PMID: 33282199.
      View in: PubMed   Mentions:
    4. Moving the dial on prenatal stress mechanisms of neurodevelopmental vulnerability to mental health problems: A personalized prevention proof of concept. Dev Psychobiol. 2021 May; 63(4):622-640. Wakschlag LS, Tandon D, Krogh-Jespersen S, Petitclerc A, Nielsen A, Ghaffari R, Mithal L, Bass M, Ward E, Berken J, Fareedi E, Cummings P, Mestan K, Norton ES, Grobman W, Rogers J, Moskowitz J, Alshurafa N. PMID: 33225463.
      View in: PubMed   Mentions: 1     Fields:    
    5. Soluble Klotho, a biomarker and therapeutic strategy to reduce bronchopulmonary dysplasia and pulmonary hypertension in preterm infants. Sci Rep. 2020 07 23; 10(1):12368. Batlahally S, Franklin A, Damianos A, Huang J, Chen P, Sharma M, Duara J, Keerthy D, Zambrano R, Shehadeh LA, Martinez EC, DeFreitas MJ, Kulandavelu S, Abitbol CL, Freundlich M, Kanashiro-Takeuchi RM, Schmidt A, Benny M, Wu S, Mestan KK, Young KC. PMID: 32704023.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    6. The impact of placental pathology discordance in multiple gestation pregnancies on bronchopulmonary dysplasia-associated pulmonary hypertension. Pulm Circ. 2020 Jan-Mar; 10(1):2045894020910674. Franklin A, Yallapragada S, Birkett R, Grobman W, Ernst LM, Mestan K. PMID: 32215199.
      View in: PubMed   Mentions:
    7. Variations in Umbilical Cord Hematopoietic and Mesenchymal Stem Cells With Bronchopulmonary Dysplasia. Front Pediatr. 2019; 7:475. Chaudhury S, Saqibuddin J, Birkett R, Falcon-Girard K, Kraus M, Ernst LM, Grobman W, Mestan KK. PMID: 31799226.
      View in: PubMed   Mentions:
    8. Cord blood alpha klotho is decreased in small for gestational age preterm infants with placental lesions of accelerated aging. Placenta. 2019 11; 87:1-7. Franklin AD, Saqibuddin J, Stephens K, Birkett R, Marsden L, Ernst LM, Mestan KK. PMID: 31499336.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    9. Racial differences in placental pathology among very preterm births. Placenta. 2019 08; 83:37-42. Matoba N, Yallapragada S, Davis MM, Ernst LM, Collins JW, Mestan KK. PMID: 31477205.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Fetal cord blood and tissue immune responses to chronic placental inflammation and chorioamnionitis. Allergy Asthma Clin Immunol. 2018; 14:66. Singh AM, Sherenian MG, Kim KY, Erickson KA, Yang A, Mestan K, Ernst LM, Kumar R. PMID: 30473713.
      View in: PubMed   Mentions:
    11. An update on the diagnosis and management of bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension. Semin Perinatol. 2018 11; 42(7):432-443. Berkelhamer SK, Mestan KK, Steinhorn R. PMID: 30384985.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansPHPublic Health
    12. Umbilical cord blood metabolomics reveal distinct signatures of dyslipidemia prior to bronchopulmonary dysplasia and pulmonary hypertension. . 2018 11 01; 315(5):L870-L881. La Frano MR, Fahrmann JF, Grapov D, Pedersen TL, Newman JW, Fiehn O, Underwood MA, Mestan K, Steinhorn RH, Wedgwood S. PMID: 30113229.
      View in: PubMed   Mentions:
    13. Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy. Medicine (Baltimore). 2018 Mar; 97(9):e0043. Liu X, Hong X, Tsai HJ, Mestan KK, Shi M, Kefi A, Hao K, Chen Q, Wang G, Caruso D, Geng H, Gao Y, He J, Kumar R, Wang H, Yu Y, Bartell T, Tan XD, Schleimer RP, Weeks DE, Pongracic JA, Wang X. PMID: 29489655.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    14. Vital signs analysis algorithm detects inflammatory response in premature infants with late onset sepsis and necrotizing enterocolitis. Early Hum Dev. 2018 02; 117:83-89. Mithal LB, Yogev R, Palac HL, Kaminsky D, Gur I, Mestan KK. PMID: 29351876.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    15. Cord Blood Biomarkers of Placental Maternal Vascular Underperfusion Predict Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension. J Pediatr. 2017 06; 185:33-41. Mestan KK, Gotteiner N, Porta N, Grobman W, Su EJ, Ernst LM. PMID: 28162769.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    16. Cord Blood Acute Phase Reactants Predict Early Onset Neonatal Sepsis in Preterm Infants. PLoS One. 2017; 12(1):e0168677. Mithal LB, Palac HL, Yogev R, Ernst LM, Mestan KK. PMID: 28045978.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    17. Computerized vital signs analysis and late onset infections in extremely low gestational age infants. J Perinat Med. 2016 Jul 01; 44(5):491-7. Mithal LB, Yogev R, Palac H, Gur I, Mestan KK. PMID: 26845716.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    18. Cord Blood Ferritin and Fibroblast Growth Factor-23 Levels in Neonates. J Clin Endocrinol Metab. 2016 04; 101(4):1673-9. Ali FN, Josefson J, Mendez AJ, Mestan K, Wolf M. PMID: 26859104.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    19. Flow Cytometry Reveals Similarities Between Lung Macrophages in Humans and Mice. Am J Respir Cell Mol Biol. 2016 Jan; 54(1):147-9. Bharat A, Bhorade SM, Morales-Nebreda L, McQuattie-Pimentel AC, Soberanes S, Ridge K, DeCamp MM, Mestan KK, Perlman H, Budinger GR, Misharin AV. PMID: 26274047.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    20. Placental Villous Vascularity Is Decreased in Premature Infants with Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension. Pediatr Dev Pathol. 2016 Mar-Apr; 19(2):101-7. Yallapragada SG, Mestan KK, Palac H, Porta N, Gotteiner N, Hamvas A, Grobman W, Ernst LM. PMID: 26366786.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    21. Impaired fetoplacental angiogenesis in growth-restricted fetuses with abnormal umbilical artery doppler velocimetry is mediated by aryl hydrocarbon receptor nuclear translocator (ARNT). J Clin Endocrinol Metab. 2015 Jan; 100(1):E30-40. Su EJ, Xin H, Yin P, Dyson M, Coon J, Farrow KN, Mestan KK, Ernst LM. PMID: 25343232.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    22. Response to "Letter to the editor: Angiogenesis factors in cord blood and post-natal growth failure: a biochemical evaluation". Early Hum Dev. 2014 Sep; 90(9):543. Baehl Voller S, Mestan KK. PMID: 24954697.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Cord blood biomarkers of vascular endothelial growth (VEGF and sFlt-1) and postnatal growth: a preterm birth cohort study. Early Hum Dev. 2014 Apr; 90(4):195-200. Voller SB, Chock S, Ernst LM, Su E, Liu X, Farrow KN, Mestan KK. PMID: 24480606.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    24. Maternal preconception body mass index and offspring cord blood DNA methylation: exploration of early life origins of disease. Environ Mol Mutagen. 2014 Apr; 55(3):223-30. Liu X, Chen Q, Tsai HJ, Wang G, Hong X, Zhou Y, Zhang C, Liu C, Liu R, Wang H, Zhang S, Yu Y, Mestan KK, Pearson C, Otlans P, Zuckerman B, Wang X. PMID: 24243566.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    25. Pulmonary hypertension in bronchopulmonary dysplasia. Semin Perinatol. 2013 Apr; 37(2):124-31. Berkelhamer SK, Mestan KK, Steinhorn RH. PMID: 23582967.
      View in: PubMed   Mentions: 54     Fields:    Translation:Humans
    26. Cord blood 8-isoprostane in the preterm infant. Early Hum Dev. 2012 Aug; 88(8):683-9. Mestan K, Matoba N, Arguelles L, Harvey C, Ernst LM, Farrow K, Wang X. PMID: 22425039.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    27. Genomic sequencing in clinical trials. J Transl Med. 2011 Dec 30; 9:222. Mestan KK, Ilkhanoff L, Mouli S, Lin S. PMID: 22206293.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    28. Fetal origins of neonatal lung disease: understanding the pathogenesis of bronchopulmonary dysplasia. . 2011 Dec; 301(6):L858-9. Mestan KK, Steinhorn RH. PMID: 21964401.
      View in: PubMed   Mentions:
    29. Placental inflammatory response is associated with poor neonatal growth: preterm birth cohort study. Pediatrics. 2010 Apr; 125(4):e891-8. Mestan K, Yu Y, Matoba N, Cerda S, Demmin B, Pearson C, Ortiz K, Wang X. PMID: 20308216.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    30. Maternal obesity, diabetes mellitus and cord blood biomarkers in large-for-gestational age infants. J Pediatr Biochem. 2010 Jan 01; 1(3):217-224. Mestan K, Ouyang F, Matoba N, Pearson C, Ortiz K, Wang X. PMID: 21814537.
      View in: PubMed   Mentions:
    31. Cord blood biomarkers of the fetal inflammatory response. J Matern Fetal Neonatal Med. 2009 May; 22(5):379-87. Mestan K, Yu Y, Thorsen P, Skogstrand K, Matoba N, Liu X, Kumar R, Hougaard DM, Gupta M, Pearson C, Ortiz K, Bauchner H, Wang X. PMID: 19529994.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    32. Differential patterns of 27 cord blood immune biomarkers across gestational age. Pediatrics. 2009 May; 123(5):1320-8. Matoba N, Yu Y, Mestan K, Pearson C, Ortiz K, Porta N, Thorsen P, Skogstrand K, Hougaard DM, Zuckerman B, Wang X. PMID: 19403498.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    33. The joint association between F5 gene polymorphisms and maternal smoking during pregnancy on preterm delivery. Hum Genet. 2009 Jan; 124(6):659-68. Yu Y, Tsai HJ, Liu X, Mestan K, Zhang S, Pearson C, Ortiz K, Xu X, Zuckerman B, Wang X. PMID: 19020903.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    34. Maternal cigarette smoking, metabolic gene polymorphisms, and preterm delivery: new insights on GxE interactions and pathogenic pathways. Hum Genet. 2008 May; 123(4):359-69. Tsai HJ, Liu X, Mestan K, Yu Y, Zhang S, Fang Y, Pearson C, Ortiz K, Zuckerman B, Bauchner H, Cerda S, Stubblefield PG, Xu X, Wang X. PMID: 18320229.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    35. Impact of clinical and histologic correlates of maternal and fetal inflammatory response on gestational age in preterm births. J Matern Fetal Neonatal Med. 2007 Jan; 20(1):39-46. Gupta M, Mestan KK, Martin CR, Pearson C, Ortiz K, Fu L, Stubblefield P, Cerda S, Kasznica JM, Wang X. PMID: 17437198.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    36. Neurodevelopmental outcomes of premature infants treated with inhaled nitric oxide. N Engl J Med. 2005 Jul 07; 353(1):23-32. Mestan KK, Marks JD, Hecox K, Huo D, Schreiber MD. PMID: 16000353.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCTClinical Trials
    37. Cardiopulmonary effects of nebulized sodium nitroprusside in term infants with hypoxic respiratory failure. J Pediatr. 2003 Nov; 143(5):640-3. Mestan KK, Carlson AD, White M, Powers JA, Morgan S, Meadow W, Schreiber MD. PMID: 14615737.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
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