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Joseph Califano

Title(s)Physician in Chief - Moores Cancer Center, Surgery
SchoolHealth Sciences
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    Other Positions
    Title(s)Director, Head and Neck Cancer Center

    Title(s)Professor, Surgery


    Collapse Research 
    Collapse Research Activities and Funding
    Optimizing an assay for high risk HPV DNA in body fluids
    NIH/NCI UH3CA211396May 12, 2017 - Jun 30, 2021
    Role: Principal Investigator
    Optimizing an assay for high risk HPV DNA in body fluids
    NIH/NCI UH2CA211396May 12, 2017 - Apr 30, 2019
    Role: Principal Investigator
    A novel point of care test for oral and oropharyngeal cancer risk
    NIH/NCI R01CA204264Jan 3, 2017 - Dec 31, 2021
    Role: Principal Investigator
    Howard University Summer Research Experience Program in Oral Health Disparity for Underrepresented Racial and Ethnic Students
    NIH/NIDCR R25DE025778Jan 1, 2016 - Dec 31, 2020
    Role: Principal Investigator
    (2/2) Howard University/Johns Hopkins Partnership in HPV-Related Cancer Research
    NIH P20CA192988Sep 20, 2014 - Aug 31, 2018
    Role: Co-Investigator
    Epigenetic Biomarker Discovery in HPV Related HNSCC
    NIH/NIDCR R01DE023347Apr 1, 2013 - Mar 31, 2018
    Role: Principal Investigator
    Validation of epigenetic biomarkers of head and neck cancer progression--OLD
    NIH/NIDCR RC2DE020789Sep 25, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Integrative Pathway Analysis of Epigenomic/transcriptional Alteration in HNSCC
    NIH/NIDCR RC1DE020324Sep 22, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Tadalafil Induced Modulation of Immune Response in HNSCC
    NIH/NCI R21CA135635Jan 1, 2009 - Dec 31, 2012
    Role: Principal Investigator
    Cetuximab for Treatment of High-risk Pre-malignant Upper Aerodigestive Lesions
    NIH/NCI R21CA126055Feb 1, 2008 - Jan 31, 2012
    Role: Principal Investigator
    HU/JHU Head and Neck Cancer Translational Research and *
    NIH/NCI P20CA118782Sep 30, 2005 - Aug 31, 2009
    Role: Principal Investigator
    Molecular Anatomy of Mitochondria in HNSC
    NIH/NIDCR R01DE015939Apr 1, 2004 - Feb 28, 2008
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ando M, Saito Y, Xu G, Bui NQ, Medetgul-Ernar K, Pu M, Fisch K, Ren S, Sakai A, Fukusumi T, Liu C, Haft S, Pang J, Mark A, Gaykalova DA, Guo T, Favorov AV, Yegnasubramanian S, Fertig EJ, Ha P, Tamayo P, Yamasoba T, Ideker T, Messer K, Califano JA. Publisher Correction: Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers. Nat Commun. 2019 May 29; 10(1):2415. PMID: 31142745.
      View in: PubMed
    2. Ando M, Saito Y, Xu G, Bui NQ, Medetgul-Ernar K, Pu M, Fisch K, Ren S, Sakai A, Fukusumi T, Liu C, Haft S, Pang J, Mark A, Gaykalova DA, Guo T, Favorov AV, Yegnasubramanian S, Fertig EJ, Ha P, Tamayo P, Yamasoba T, Ideker T, Messer K, Califano JA. Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers. Nat Commun. 2019 05 16; 10(1):2188. PMID: 31097695.
      View in: PubMed
    3. Haft S, Ren S, Xu G, Mark A, Fisch K, Guo TW, Khan Z, Pang J, Ando M, Liu C, Sakai A, Fukusumi T, Califano JA. Mutation of chromatin regulators and focal hotspot alterations characterize human papillomavirus-positive oropharyngeal squamous cell carcinoma. Cancer. 2019 Apr 01. PMID: 30933315.
      View in: PubMed
    4. Wang Z, Feng X, Molinolo AA, Martin D, Vitale-Cross L, Nohata N, Ando M, Wahba A, Amornphimoltham P, Wu X, Gilardi M, Allevato M, Wu V, Steffen DJ, Tofilon P, Sonenberg N, Califano J, Chen Q, Lippman SM, Gutkind JS. 4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer. Cancer Res. 2019 Apr 01; 79(7):1438-1450. PMID: 30894372.
      View in: PubMed
    5. Miyauchi S, Kim SS, Pang J, Gold KA, Gutkind JS, Califano JA, Mell LK, Cohen EEW, Sharabi AB. Immune Modulation of Head and Neck Squamous Cell Carcinoma and the Tumor Microenvironment by Conventional Therapeutics. Clin Cancer Res. 2019 Jul 15; 25(14):4211-4223. PMID: 30814108.
      View in: PubMed
    6. Pang J, Ching HH, Sobel RH, Orosco RK, Califano JA, Wang RC, Sanghvi P, Coffey CS. Implementation of submandibular gland transfer: A multi-institutional study of feasibility and time to treatment. Head Neck. 2019 Feb 05. PMID: 30723965.
      View in: PubMed
    7. Gleber-Netto FO, Rao X, Guo T, Xi Y, Gao M, Shen L, Erikson K, Kalu NN, Ren S, Xu G, Fisch KM, Akagi K, Seiwert T, Gillison M, Frederick MJ, Johnson FM, Wang J, Myers JN, Califano J, Skinner HD, Pickering CR. Variations in HPV function are associated with survival in squamous cell carcinoma. JCI Insight. 2019 Jan 10; 4(1). PMID: 30626753.
      View in: PubMed
    8. Califano JA, Khan Z, Noonan KA, Rudraraju L, Zhang Z, Wang H, Goodman S, Gourin CG, Ha PK, Fakhry C, Saunders J, Levine M, Tang M, Neuner G, Richmon JD, Blanco R, Agrawal N, Koch WM, Marur S, Weed DT, Serafini P, Borrello I. Correction: Tadalafil Augments Tumor-specific Immunity in Patients with Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2018 Dec 01; 24(23):6100. PMID: 30510089.
      View in: PubMed
    9. Bryant AK, Sojourner EJ, Vitzthum LK, Zakeri K, Shen H, Nguyen C, Murphy JD, Califano JA, Cohen EEW, Mell LK. Prognostic Role of p16 in Nonoropharyngeal Head and Neck Cancer. J Natl Cancer Inst. 2018 Dec 01; 110(12):1393-1399. PMID: 29878161.
      View in: PubMed
    10. Burton BN, Okwuegbuna O, Jafari A, Califano J, Brumund KT, Gabriel RA. Association of Preoperative Anemia With 30-Day Morbidity and Mortality Among Patients With Thyroid Cancer Who Undergo Thyroidectomy. JAMA Otolaryngol Head Neck Surg. 2018 Nov 29. PMID: 30489623.
      View in: PubMed
    11. Saba NF, Li S, Hussain ZA, Subramanian R, Califano JA, Chung CH. Locally advanced high-risk HPV related oropharyngeal squamous cell carcinoma (OPSCC); have we forgotten it is a different disease? Cancers Head Neck. 2018; 3:8. PMID: 31093361.
      View in: PubMed
    12. Ren S, Gaykalova D, Wang J, Guo T, Danilova L, Favorov A, Fertig E, Bishop J, Khan Z, Flam E, Wysocki PT, DeJong P, Ando M, Liu C, Sakai A, Fukusumi T, Haft S, Sadat S, Califano JA. Discovery and development of differentially methylated regions in human papillomavirus-related oropharyngeal squamous cell carcinoma. Int J Cancer. 2018 11 15; 143(10):2425-2436. PMID: 30070359.
      View in: PubMed
    13. Panuganti B, Qiu Y, Messing B, Lee G, Fakhry C, Blanco R, Ha P, Messer K, Califano JA. Effects of a Comprehensive Performance Improvement Strategy on Postoperative Adverse Events in Head and Neck Surgery. Otolaryngol Head Neck Surg. 2018 Aug 28; 194599818793887. PMID: 30149772.
      View in: PubMed
    14. Kelley DZ, Flam EL, Guo T, Danilova LV, Zamuner FT, Bohrson C, Considine M, Windsor EJ, Bishop JA, Zhang C, Koch WM, Sidransky D, Westra WH, Chung CH, Califano JA, Wheelan S, Favorov AV, Florea L, Fertig EJ, Gaykalova DA. Functional characterization of alternatively spliced GSN in head and neck squamous cell carcinoma. Transl Res. 2018 12; 202:109-119. PMID: 30118659.
      View in: PubMed
    15. Liu C, Guo T, Xu G, Sakai A, Ren S, Fukusumi T, Ando M, Sadat S, Saito Y, Khan Z, Fisch KM, Califano J. Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant. Clin Cancer Res. 2018 Oct 15; 24(20):5123-5132. PMID: 29945995.
      View in: PubMed
    16. Moss WJ, Finegersh A, Pang J, Califano JA, Coffey CS, Orosco RK, Brumund KT. Needle Biopsy of Routine Thyroid Nodules Should Be Performed Using a Capillary Action Technique with 24- to 27-Gauge Needles: A Systematic Review and Meta-Analysis. Thyroid. 2018 07; 28(7):857-863. PMID: 29742978.
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    17. Afsari B, Guo T, Considine M, Florea L, Kagohara LT, Stein-O'Brien GL, Kelley D, Flam E, Zambo KD, Ha PK, Geman D, Ochs MF, Califano JA, Gaykalova DA, Favorov AV, Fertig EJ. Splice Expression Variation Analysis (SEVA) for inter-tumor heterogeneity of gene isoform usage in cancer. Bioinformatics. 2018 06 01; 34(11):1859-1867. PMID: 29342249.
      View in: PubMed
    18. Rettig EM, Bishop JA, Agrawal N, Chung CH, Sharma R, Zamuner F, Li RJ, Koch WM, Califano JA, Guo T, Gaykalova DA, Fakhry C. HEY1 is expressed independent of NOTCH1 and is associated with poor prognosis in head and neck squamous cell carcinoma. Oral Oncol. 2018 Jul; 82:168-175. PMID: 29909892.
      View in: PubMed
    19. Rajagopalan P, Patel K, Jain AP, Nanjappa V, Datta KK, Subbannayya T, Mangalaparthi KK, Kumari A, Manoharan M, Coral K, Murugan S, Nair B, Prasad TSK, Mathur PP, Gupta R, Gupta R, Khanna-Gupta A, Califano J, Sidransky D, Gowda H, Chatterjee A. Molecular alterations associated with chronic exposure to cigarette smoke and chewing tobacco in normal oral keratinocytes. Cancer Biol Ther. 2018; 19(9):773-785. PMID: 29723088.
      View in: PubMed
    20. Babu N, Mohan S, Nanjappa V, Chavan S, Advani J, Khan AA, Renuse S, Radhakrishnan A, Prasad TSK, Kumar RV, Ray JG, Biswas M, Thiyagarajan S, Califano JA, Sidransky D, Gowda H, Chatterjee A. Identification of potential biomarkers of head and neck squamous cell carcinoma using iTRAQ based quantitative proteomic approach. Data Brief. 2018 Aug; 19:1124-1130. PMID: 30225281.
      View in: PubMed
    21. Stein-O'Brien G, Kagohara LT, Li S, Thakar M, Ranaweera R, Ozawa H, Cheng H, Considine M, Schmitz S, Favorov AV, Danilova LV, Califano JA, Izumchenko E, Gaykalova DA, Chung CH, Fertig EJ. Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance. Genome Med. 2018 05 23; 10(1):37. PMID: 29792227.
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    22. Pang J, Tringale KR, Tapia VJ, Panuganti BA, Qualliotine JR, Jafari A, Haft SJ, Friedman LS, Furnish T, Brumund KT, Califano JA, Coffey CS. Opioid prescribing practices in patients undergoing surgery for oral cavity cancer. Laryngoscope. 2018 10; 128(10):2361-2366. PMID: 29756393.
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    23. Bhat MY, Advani J, Rajagopalan P, Patel K, Nanjappa V, Solanki HS, Patil AH, Bhat FA, Mathur PP, Nair B, Prasad TSK, Califano JA, Sidransky D, Gowda H, Chatterjee A. Cigarette smoke and chewing tobacco alter expression of different sets of miRNAs in oral keratinocytes. Sci Rep. 2018 May 04; 8(1):7040. PMID: 29728663.
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    24. Orosco RK, Califano JA. HPV status, like politics, is local-evaluating p16 staining and a new staging system in a Dutch cohort of oropharynx cancer. Ann Oncol. 2018 May 01; 29(5):1089-1090. PMID: 29788169.
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    25. Orosco RK, Tapia VJ, Califano JA, Clary B, Cohen EEW, Kane C, Lippman SM, Messer K, Molinolo A, Murphy JD, Pang J, Sacco A, Tringale KR, Wallace A, Nguyen QT. Positive Surgical Margins in the 10 Most Common Solid Cancers. Sci Rep. 2018 Apr 09; 8(1):5686. PMID: 29632347.
      View in: PubMed
    26. Fukusumi T, Califano JA. The NOTCH Pathway in Head and Neck Squamous Cell Carcinoma. J Dent Res. 2018 06; 97(6):645-653. PMID: 29489439.
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    27. Rajagopalan P, Nanjappa V, Patel K, Jain AP, Mangalaparthi KK, Patil AH, Nair B, Mathur PP, Keshava Prasad TS, Califano JA, Sidransky D, Gowda H, Chatterjee A. Role of protein kinase N2 (PKN2) in cigarette smoke-mediated oncogenic transformation of oral cells. J Cell Commun Signal. 2018 Dec; 12(4):709-721. PMID: 29480433.
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    28. Karia PS, Morgan FC, Califano JA, Schmults CD. Comparison of Tumor Classifications for Cutaneous Squamous Cell Carcinoma of the Head and Neck in the 7th vs 8th Edition of the AJCC Cancer Staging Manual. JAMA Dermatol. 2018 Feb 01; 154(2):175-181. PMID: 29261835.
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    29. Krishnan AR, Qu Y, Li PX, Zou AE, Califano JA, Wang-Rodriguez J, Ongkeko WM. Computational methods reveal novel functionalities of PIWI-interacting RNAs in human papillomavirus-induced head and neck squamous cell carcinoma. Oncotarget. 2018 Jan 12; 9(4):4614-4624. PMID: 29435129.
      View in: PubMed
    30. Pang J, Tringale KR, Tapia VJ, Moss WJ, May ME, Furnish T, Barnachea L, Brumund KT, Sacco AG, Weisman RA, Nguyen QT, Harris JP, Coffey CS, Califano JA. Chronic Opioid Use Following Surgery for Oral Cavity Cancer. JAMA Otolaryngol Head Neck Surg. 2017 12 01; 143(12):1187-1194. PMID: 28445584.
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    31. Fukusumi T, Guo TW, Sakai A, Ando M, Ren S, Haft S, Liu C, Amornphimoltham P, Gutkind JS, Califano JA. The NOTCH4-HEY1 Pathway Induces Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2018 Feb 01; 24(3):619-633. PMID: 29146722.
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    32. Finegersh A, Kulich S, Guo T, Favorov AV, Fertig EJ, Danilova LV, Gaykalova DA, Califano JA, Duvvuri U. DNA methylation regulates TMEM16A/ANO1 expression through multiple CpG islands in head and neck squamous cell carcinoma. Sci Rep. 2017 Nov 09; 7(1):15173. PMID: 29123240.
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    33. Quon H, Vapiwala N, Forastiere A, Kennedy EB, Adelstein DJ, Boykin H, Califano JA, Holsinger FC, Nussenbaum B, Rosenthal DI, Siu LL, Waldron JN. Radiation Therapy for Oropharyngeal Squamous Cell Carcinoma: American Society of Clinical Oncology Endorsement of the American Society for Radiation Oncology Evidence-Based Clinical Practice Guideline. J Clin Oncol. 2017 Dec 20; 35(36):4078-4090. PMID: 29064744.
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    34. Kelley DZ, Flam EL, Izumchenko E, Danilova LV, Wulf HA, Guo T, Singman DA, Afsari B, Skaist AM, Considine M, Welch JA, Stavrovskaya E, Bishop JA, Westra WH, Khan Z, Koch WM, Sidransky D, Wheelan SJ, Califano JA, Favorov AV, Fertig EJ, Gaykalova DA. Integrated Analysis of Whole-Genome ChIP-Seq and RNA-Seq Data of Primary Head and Neck Tumor Samples Associates HPV Integration Sites with Open Chromatin Marks. Cancer Res. 2017 12 01; 77(23):6538-6550. PMID: 28947419.
      View in: PubMed
    35. Guo T, Sakai A, Afsari B, Considine M, Danilova L, Favorov AV, Yegnasubramanian S, Kelley DZ, Flam E, Ha PK, Khan Z, Wheelan SJ, Gutkind JS, Fertig EJ, Gaykalova DA, Califano J. A Novel Functional Splice Variant of AKT3 Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers. Cancer Res. 2017 10 01; 77(19):5248-5258. PMID: 28733453.
      View in: PubMed
    36. Qualliotine JR, Califano JA, Li RJ, Gold D, Messing B, Lee G, Ha P, Fakhry C. Human papillomavirus tumour status is not associated with a positive depression screen for patients with oropharyngeal cancer. J Laryngol Otol. 2017 Sep; 131(9):760-767. PMID: 28720154.
      View in: PubMed
    37. Krishnan AR, Zheng H, Kwok JG, Qu Y, Zou AE, Korrapati A, Li PX, Califano JA, Hovell MF, Wang-Rodriguez J, Ongkeko WM. A comprehensive study of smoking-specific microRNA alterations in head and neck squamous cell carcinoma. Oral Oncol. 2017 09; 72:56-64. PMID: 28797462.
      View in: PubMed
    38. Radhakrishnan A, Nanjappa V, Raja R, Sathe G, Puttamallesh VN, Jain AP, Pinto SM, Balaji SA, Chavan S, Sahasrabuddhe NA, Mathur PP, Kumar MM, Prasad TSK, Santosh V, Sukumar G, Califano JA, Rangarajan A, Sidransky D, Pandey A, Gowda H, Chatterjee A. Corrigendum: A dual specificity kinase, DYRK1A, as a potential therapeutic target for head and neck squamous cell carcinoma. Sci Rep. 2017 06 26; 7:46864. PMID: 28650432.
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    39. Messing BP, Ward EC, Lazarus CL, Kim M, Zhou X, Silinonte J, Gold D, Harrer K, Ulmer K, Merritt S, Neuner G, Levine M, Blanco R, Saunders J, Califano J. Prophylactic Swallow Therapy for Patients with Head and Neck Cancer Undergoing Chemoradiotherapy: A Randomized Trial. Dysphagia. 2017 08; 32(4):487-500. PMID: 28444488.
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    40. Zhao Y, Ling Z, Hao Y, Pang X, Han X, Califano JA, Shan L, Gu X. MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma. Oncotarget. 2017 Apr 11; 8(15):25005-25020. PMID: 28212569.
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    41. Gaykalova DA, Zizkova V, Guo T, Tiscareno I, Wei Y, Vatapalli R, Hennessey PT, Ahn J, Danilova L, Khan Z, Bishop JA, Gutkind JS, Koch WM, Westra WH, Fertig EJ, Ochs MF, Califano JA. Integrative computational analysis of transcriptional and epigenetic alterations implicates DTX1 as a putative tumor suppressor gene in HNSCC. Oncotarget. 2017 Feb 28; 8(9):15349-15363. PMID: 28146432.
      View in: PubMed
    42. Tota JE, Anderson WF, Coffey C, Califano J, Cozen W, Ferris RL, St John M, Cohen EE, Chaturvedi AK. Rising incidence of oral tongue cancer among white men and women in the United States, 1973-2012. Oral Oncol. 2017 04; 67:146-152. PMID: 28351569.
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    43. Patel MA, Eytan DF, Bishop J, Califano JA. Favorable Swallowing Outcomes following Vagus Nerve Sacrifice for Vagal Schwannoma Resection. Otolaryngol Head Neck Surg. 2017 02; 156(2):329-333. PMID: 27899468.
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    44. Rosculet N, Zhou XC, Ha P, Tang M, Levine MA, Neuner G, Califano J. Neutrophil-to-lymphocyte ratio: Prognostic indicator for head and neck squamous cell carcinoma. Head Neck. 2017 04; 39(4):662-667. PMID: 28075517.
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    45. Krishnan AR, Korrapati A, Zou AE, Qu Y, Wang XQ, Califano JA, Wang-Rodriguez J, Lippman SM, Hovell MF, Ongkeko WM. Smoking status regulates a novel panel of PIWI-interacting RNAs in head and neck squamous cell carcinoma. Oral Oncol. 2017 02; 65:68-75. PMID: 28109471.
      View in: PubMed
    46. Oweida A, Bhatia S, Hirsch K, Calame D, Griego A, Keysar S, Pitts T, Sharma J, Eckhardt G, Jimeno A, Wang XJ, Parkash G, Califano J, Karam SD. Ephrin-B2 overexpression predicts for poor prognosis and response to therapy in solid tumors. Mol Carcinog. 2017 03; 56(3):1189-1196. PMID: 27649287.
      View in: PubMed
    47. Radhakrishnan A, Nanjappa V, Raja R, Sathe G, Puttamallesh VN, Jain AP, Pinto SM, Balaji SA, Chavan S, Sahasrabuddhe NA, Mathur PP, Kumar MM, Prasad TS, Santosh V, Sukumar G, Califano JA, Rangarajan A, Sidransky D, Pandey A, Gowda H, Chatterjee A. A dual specificity kinase, DYRK1A, as a potential therapeutic target for head and neck squamous cell carcinoma. Sci Rep. 2016 10 31; 6:36132. PMID: 27796319.
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    48. Callejas-Valera JL, Iglesias-Bartolome R, Amornphimoltham P, Palacios-Garcia J, Martin D, Califano JA, Molinolo AA, Gutkind JS. mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model. Carcinogenesis. 2016 10; 37(10):1014-25. PMID: 27538837.
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    49. D'Souza G, Zhang Y, Merritt S, Gold D, Robbins HA, Buckman V, Gerber J, Eisele DW, Ha P, Califano J, Fakhry C. Patient experience and anxiety during and after treatment for an HPV-related oropharyngeal cancer. Oral Oncol. 2016 09; 60:90-5. PMID: 27531878.
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    50. Sobel RH, Blanco R, Ha PK, Califano JA, Kumar R, Richmon JD. Implementation of a comprehensive competency-based transoral robotic surgery training curriculum with ex vivo dissection models. Head Neck. 2016 10; 38(10):1553-63. PMID: 27152633.
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    51. Khan Z, Epstein JB, Marur S, Boyd Gillespie M, Feldman L, Tsai HL, Zhang Z, Wang H, Sciubba J, Ferris RL, Grandis JR, Gibson M, Koch W, Tufano R, Westra W, Tsottles N, Ozawa H, Chung CH, Califano JA. Corrigendum to "Cetuximab activity in dysplastic lesions of the upper aerodigestive tract" [Oral Oncol. 53 (2016) 60-66]. Oral Oncol. 2016 Jun; 57:e8. PMID: 27085635.
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    52. Guo T, Gaykalova DA, Considine M, Wheelan S, Pallavajjala A, Bishop JA, Westra WH, Ideker T, Koch WM, Khan Z, Fertig EJ, Califano JA. Characterization of functionally active gene fusions in human papillomavirus related oropharyngeal squamous cell carcinoma. Int J Cancer. 2016 07 15; 139(2):373-82. PMID: 26949921.
      View in: PubMed
    53. Yamaguchi K, Iglesias-Bartolomé R, Wang Z, Callejas-Valera JL, Amornphimoltham P, Molinolo AA, Cohen EE, Califano JA, Lippman SM, Luo J, Gutkind JS. A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers. Oncotarget. 2016 Mar 08; 7(10):10696-709. PMID: 26882569; PMCID: PMC4905432.
    54. Stansfield JC, Rusay M, Shan R, Kelton C, Gaykalova DA, Fertig EJ, Califano JA, Ochs MF. Toward Signaling-Driven Biomarkers Immune to Normal Tissue Contamination. Cancer Inform. 2016; 15:15-21. PMID: 26884679; PMCID: PMC4750896.
    55. Radhakrishnan A, Nanjappa V, Raja R, Sathe G, Chavan S, Nirujogi RS, Patil AH, Solanki H, Renuse S, Sahasrabuddhe NA, Mathur PP, Prasad TS, Kumar P, Califano JA, Sidransky D, Pandey A, Gowda H, Chatterjee A. Dysregulation of splicing proteins in head and neck squamous cell carcinoma. Cancer Biol Ther. 2016; 17(2):219-29. PMID: 26853621.
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    56. Fakhry C, Qualliotine JR, Zhang Z, Agrawal N, Gaykalova DA, Bishop JA, Subramaniam RM, Koch WM, Chung CH, Eisele DW, Califano J, Viscidi RP. Serum Antibodies to HPV16 Early Proteins Warrant Investigation as Potential Biomarkers for Risk Stratification and Recurrence of HPV-Associated Oropharyngeal Cancer. Cancer Prev Res (Phila). 2016 Feb; 9(2):135-41. PMID: 26701665; PMCID: PMC4811031 [Available on 02/01/17].
    57. Khan Z, Epstein JB, Marur S, Gillespie MB, Feldman L, Tsai HL, Zhang Z, Wang H, Sciubba J, Ferris R, Grandis JR, Gibson M, Koch W, Tufano R, Westra W, Tsottles N, Ozawa H, Chung C, Califano JA. Cetuximab activity in dysplastic lesions of the upper aerodigestive tract. Oral Oncol. 2016 Feb; 53:60-6. PMID: 26686755.
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    58. Joseph AW, Guo T, Hur K, Xie Y, Yin L, Califano JA, Ha PK, Quon H, Richmon JD, Eisele DW, Agrawal N, Fakhry C. Disease-free survival after salvage therapy for recurrent oropharyngeal squamous cell carcinoma. Head Neck. 2016 04; 38 Suppl 1:E1501-9. PMID: 26558328.
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    59. Gaykalova DA, Vatapalli R, Wei Y, Tsai HL, Wang H, Zhang C, Hennessey PT, Guo T, Tan M, Li R, Ahn J, Khan Z, Westra WH, Bishop JA, Zaboli D, Koch WM, Khan T, Ochs MF, Califano JA. Outlier Analysis Defines Zinc Finger Gene Family DNA Methylation in Tumors and Saliva of Head and Neck Cancer Patients. PLoS One. 2015; 10(11):e0142148. PMID: 26544568; PMCID: PMC4636259.
    60. Li RJ, Zhou XC, Fakhry C, Negrin J, Lee G, Ha P, Blanco R, Saunders J, Califano JA. Reduction of Pharyngocutaneous Fistulae in Laryngectomy Patients by a Comprehensive Performance Improvement Intervention. Otolaryngol Head Neck Surg. 2015 Dec; 153(6):927-34. PMID: 26519459.
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    61. Nanjappa V, Renuse S, Sathe GJ, Raja R, Syed N, Radhakrishnan A, Subbannayya T, Patil A, Marimuthu A, Sahasrabuddhe NA, Guerrero-Preston R, Somani BL, Nair B, Kundu GC, Prasad TK, Califano JA, Gowda H, Sidransky D, Pandey A, Chatterjee A. Chronic exposure to chewing tobacco selects for overexpression of stearoyl-CoA desaturase in normal oral keratinocytes. Cancer Biol Ther. 2015; 16(11):1593-603. PMID: 26391970; PMCID: PMC4846103 [Available on 09/21/16].
    62. Taghipour M, Marcus C, Califano J, Fakhry C, Subramaniam RM. The value of follow-up FDG-PET/CT in the management and prognosis of patients with HPV-positive oropharyngeal squamous cell carcinoma. J Med Imaging Radiat Oncol. 2015 Dec; 59(6):681-6. PMID: 26768092.
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    63. Mydlarz WK, Hennessey PT, Wang H, Carvalho AL, Califano JA. Serum biomarkers for detection of head and neck squamous cell carcinoma. Head Neck. 2016 Jan; 38(1):9-14. PMID: 24995714; PMCID: PMC4317379.
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    144. Pattani KM, Zhang Z, Demokan S, Glazer C, Loyo M, Goodman S, Sidransky D, Bermudez F, Jean-Charles G, McCaffrey T, Padhya T, Phelan J, Spivakovsky S, Bowne HY, Goldberg JD, Rolnitzky L, Robbins M, Kerr AR, Sirois D, Califano JA. Endothelin receptor type B gene promoter hypermethylation in salivary rinses is independently associated with risk of oral cavity cancer and premalignancy. Cancer Prev Res (Phila). 2010 Sep; 3(9):1093-103. PMID: 20798208; PMCID: PMC2945229.
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    147. Rosin MP, Califano JA. The epidermal growth factor receptor axis: support for a new target for oral premalignancy. Cancer Prev Res (Phila). 2010 Jul; 3(7):797-9. PMID: 20570884.
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    148. Loyo M, Guerrero-Preston R, Brait M, Hoque MO, Chuang A, Kim MS, Sharma R, Liégeois NJ, Koch WM, Califano JA, Westra WH, Sidransky D. Quantitative detection of Merkel cell virus in human tissues and possible mode of transmission. Int J Cancer. 2010 Jun 15; 126(12):2991-6. PMID: 19588496; PMCID: PMC2856748.
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    150. Zhao Y, Hao Y, Ji H, Fang Y, Guo Y, Sha W, Zhou Y, Pang X, Southerland WM, Califano JA, Gu X. Combination effects of salvianolic acid B with low-dose celecoxib on inhibition of head and neck squamous cell carcinoma growth in vitro and in vivo. Cancer Prev Res (Phila). 2010 Jun; 3(6):787-96. PMID: 20501859; PMCID: PMC2881190.
    151. Lee J, Jang SJ, Benoit N, Hoque MO, Califano JA, Trink B, Sidransky D, Mao L, Moon C. Presence of 5-methylcytosine in CpNpG trinucleotides in the human genome. Genomics. 2010 Aug; 96(2):67-72. PMID: 20382216; PMCID: PMC3164866.
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    153. Chang X, Monitto CL, Demokan S, Kim MS, Chang SS, Zhong X, Califano JA, Sidransky D. Identification of hypermethylated genes associated with cisplatin resistance in human cancers. Cancer Res. 2010 Apr 01; 70(7):2870-9. PMID: 20215521; PMCID: PMC2849007.
    154. Chuang TC, Chuang AY, Poeta L, Koch WM, Califano JA, Tufano RP. Detectable BRAF mutation in serum DNA samples from patients with papillary thyroid carcinomas. Head Neck. 2010 Feb; 32(2):229-34. PMID: 19626635.
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    155. Sun W, Liu Y, Glazer CA, Shao C, Bhan S, Demokan S, Zhao M, Rudek MA, Ha PK, Califano JA. TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization. Clin Cancer Res. 2010 Feb 01; 16(3):857-66. PMID: 20103683; PMCID: PMC2824550.
    156. Bai W, Shao C, Sun W, Ha PK, Califano JA, Cao Z. Conservative management of transnasal intracranial injury. Am J Otolaryngol. 2011 Mar-Apr; 32(2):165-7. PMID: 20060199.
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    157. Campbell CA, Della Santina CC, Meyer NC, Smith NB, Myrie OA, Stone EM, Fukushima K, Califano J, Carey JP, Hansen MR, Gantz BJ, Minor LB, Smith RJ. Polymorphisms in KCNE1 or KCNE3 are not associated with Ménière disease in the Caucasian population. Am J Med Genet A. 2010 Jan; 152A(1):67-74. PMID: 20034061.
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    161. Poeta ML, Manola J, Goldenberg D, Forastiere A, Califano JA, Ridge JA, Goodwin J, Kenady D, Saunders J, Westra W, Sidransky D, Koch WM. The Ligamp TP53 Assay for Detection of Minimal Residual Disease in Head and Neck Squamous Cell Carcinoma Surgical Margins. Clin Cancer Res. 2009 Dec 15; 15(24):7658-7665. PMID: 19996217.
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    162. Glazer CA, Smith IM, Ochs MF, Begum S, Westra W, Chang SS, Sun W, Bhan S, Khan Z, Ahrendt S, Califano JA. Integrative discovery of epigenetically derepressed cancer testis antigens in NSCLC. PLoS One. 2009 Dec 04; 4(12):e8189. PMID: 19997593; PMCID: PMC2781168.
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    164. Califano J, Nance M. Malignant melanoma. Facial Plast Surg Clin North Am. 2009 Aug; 17(3):337-48. PMID: 19698915.
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    166. Durr ML, Saunders JR, Califano JA, Tufano RP, Koch WM, Ha PK. Severe hypocalcemia complicating thyroid surgery after Roux-en-Y gastric bypass procedure. Arch Otolaryngol Head Neck Surg. 2009 May; 135(5):507-10. PMID: 19451473.
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    173. Acha-Sagredo A, Ruesga MT, Rodriguez C, Aguirregaviria JI, de Pancorbo MM, Califano JA, Aguirre JM. p53 mutation is rare in oral mucosa brushings from patients previously treated for a head and neck squamous cell carcinoma. Oral Oncol. 2009 Aug; 45(8):661-4. PMID: 19027352.
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    174. Pattani KM, Califano J. Positive sentinel lymph nodes are a negative prognostic factor for survival in T1-2 oral/oropharyngeal cancer: a long-term study on 103 patients. Ann Surg Oncol. 2009 Feb; 16(2):231-2. PMID: 19018600.
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    179. DeRubertis BG, Vouyouka A, Rhee SJ, Califano J, Karwowski J, Angle N, Faries PL, Kent KC. Percutaneous intervention for infrainguinal occlusive disease in women: equivalent outcomes despite increased severity of disease compared with men. J Vasc Surg. 2008 Jul; 48(1):150-7; discussion 157-8. PMID: 18589232.
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    182. McFate T, Mohyeldin A, Lu H, Thakar J, Henriques J, Halim ND, Wu H, Schell MJ, Tsang TM, Teahan O, Zhou S, Califano JA, Jeoung NH, Harris RA, Verma A. Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells. J Biol Chem. 2008 Aug 15; 283(33):22700-8. PMID: 18541534; PMCID: PMC2504897.
    183. Woo J, Lee J, Chae YK, Kim MS, Baek JH, Park JC, Park MJ, Smith IM, Trink B, Ratovitski E, Lee T, Park B, Jang SJ, Soria JC, Califano JA, Sidransky D, Moon C. Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation. Cancer Lett. 2008 Jun 08; 264(1):54-62. PMID: 18423983; PMCID: PMC3074481.
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    185. Prasad NB, Somervell H, Tufano RP, Dackiw AP, Marohn MR, Califano JA, Wang Y, Westra WH, Clark DP, Umbricht CB, Libutti SK, Zeiger MA. Identification of genes differentially expressed in benign versus malignant thyroid tumors. Clin Cancer Res. 2008 Jun 01; 14(11):3327-37. PMID: 18519760; PMCID: PMC3086681.
    186. Mithani SK, Smith IM, Topalian SL, Califano JA. Nonsynonymous somatic mitochondrial mutations occur in the majority of cutaneous melanomas. Melanoma Res. 2008 Jun; 18(3):214-9. PMID: 18477896.
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    188. Robbins KT, Shaha AR, Medina JE, Califano JA, Wolf GT, Ferlito A, Som PM, Day TA. Consensus statement on the classification and terminology of neck dissection. Arch Otolaryngol Head Neck Surg. 2008 May; 134(5):536-8. PMID: 18490577.
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    190. Kim MS, Lebron C, Nagpal JK, Chae YK, Chang X, Huang Y, Chuang T, Yamashita K, Trink B, Ratovitski EA, Califano JA, Sidransky D. Methylation of the DFNA5 increases risk of lymph node metastasis in human breast cancer. Biochem Biophys Res Commun. 2008 May 23; 370(1):38-43. PMID: 18346456; PMCID: PMC3094717.
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    194. Chatterjee A, Chang X, Nagpal JK, Chang S, Upadhyay S, Califano J, Trink B, Sidransky D. Targeting human 8-oxoguanine DNA glycosylase to mitochondria protects cells from 2-methoxyestradiol-induced-mitochondria-dependent apoptosis. Oncogene. 2008 Jun 12; 27(26):3710-20. PMID: 18246124.
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    196. Zhao M, Begum S, Ha PK, Westra W, Califano J. Downregulation of RAD17 in head and neck cancer. Head Neck. 2008 Jan; 30(1):35-42. PMID: 17657792.
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    197. Shan L, Hao Y, Wang S, Korotcov A, Zhang R, Wang T, Califano J, Gu X, Sridhar R, Bhujwalla ZM, Wang PC. Visualizing head and neck tumors in vivo using near-infrared fluorescent transferrin conjugate. Mol Imaging. 2008 Jan-Feb; 7(1):42-9. PMID: 18384723.
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    214. Hu S, Liu D, Tufano RP, Carson KA, Rosenbaum E, Cohen Y, Holt EH, Kiseljak-Vassiliades K, Rhoden KJ, Tolaney S, Condouris S, Tallini G, Westra WH, Umbricht CB, Zeiger MA, Califano JA, Vasko V, Xing M. Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer. Int J Cancer. 2006 Nov 15; 119(10):2322-9. PMID: 16858683.
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    215. Serafini P, Meckel K, Kelso M, Noonan K, Califano J, Koch W, Dolcetti L, Bronte V, Borrello I. Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. J Exp Med. 2006 Nov 27; 203(12):2691-702. PMID: 17101732; PMCID: PMC2118163.
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    218. Farrag TY, Lin FR, Cummings CW, Koch WM, Flint PW, Califano JA, Broussard J, Bajaj G, Tufano RP. Neck management in patients undergoing postradiotherapy salvage laryngeal surgery for recurrent/persistent laryngeal cancer. Laryngoscope. 2006 Oct; 116(10):1864-6. PMID: 17003711.
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    221. Seng TJ, Low JS, Li H, Cui Y, Goh HK, Wong ML, Srivastava G, Sidransky D, Califano J, Steenbergen RD, Rha SY, Tan J, Hsieh WS, Ambinder RF, Lin X, Chan AT, Tao Q. The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation. Oncogene. 2007 Feb 08; 26(6):934-44. PMID: 16862168.
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    222. Foster SE, Vaughan RD, Foster WH, Califano JA. Estimate of the commercial value of underage drinking and adult abusive and dependent drinking to the alcohol industry. Arch Pediatr Adolesc Med. 2006 May; 160(5):473-8. PMID: 16651488.
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    223. Jiang WW, Rosenbaum E, Mambo E, Zahurak M, Masayesva B, Carvalho AL, Zhou S, Westra WH, Alberg AJ, Sidransky D, Koch W, Califano JA. Decreased mitochondrial DNA content in posttreatment salivary rinses from head and neck cancer patients. Clin Cancer Res. 2006 Mar 01; 12(5):1564-9. PMID: 16533782.
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    224. Lee DJ, Maseyesva B, Westra W, Long D, Niparko JK, Califano J. Microsatellite analysis of recurrent vestibular schwannoma (acoustic neuroma) following stereotactic radiosurgery. Otol Neurotol. 2006 Feb; 27(2):213-9. PMID: 16436992.
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    225. Ha PK, Hdeib A, Goldenberg D, Jacene H, Patel P, Koch W, Califano J, Cummings CW, Flint PW, Wahl R, Tufano RP. The role of positron emission tomography and computed tomography fusion in the management of early-stage and advanced-stage primary head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2006 Jan; 132(1):12-6. PMID: 16415423.
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    226. Masayesva BG, Mambo E, Taylor RJ, Goloubeva OG, Zhou S, Cohen Y, Minhas K, Koch W, Sciubba J, Alberg AJ, Sidransky D, Califano J. Mitochondrial DNA content increase in response to cigarette smoking. Cancer Epidemiol Biomarkers Prev. 2006 Jan; 15(1):19-24. PMID: 16434581.
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    227. Ha PK, Califano JA. Promoter methylation and inactivation of tumour-suppressor genes in oral squamous-cell carcinoma. Lancet Oncol. 2006 Jan; 7(1):77-82. PMID: 16389187.
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    228. Zhao M, Rosenbaum E, Carvalho AL, Koch W, Jiang W, Sidransky D, Califano J. Feasibility of quantitative PCR-based saliva rinse screening of HPV for head and neck cancer. Int J Cancer. 2005 Nov 20; 117(4):605-10. PMID: 15929076.
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    229. Kim MM, Glazer CA, Mambo E, Chatterjee A, Zhao M, Sidransky D, Califano JA. Head and neck cancer cell lines exhibit differential mitochondrial repair deficiency in response to 4NQO. Oral Oncol. 2006 Feb; 42(2):201-7. PMID: 16266817.
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    230. Ha PK, Couch ME, Tufano RP, Koch WM, Califano JA. Short hospital stay after neck dissection. Otolaryngol Head Neck Surg. 2005 Nov; 133(5):677-80. PMID: 16274791.
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    231. Xing M, Westra WH, Tufano RP, Cohen Y, Rosenbaum E, Rhoden KJ, Carson KA, Vasko V, Larin A, Tallini G, Tolaney S, Holt EH, Hui P, Umbricht CB, Basaria S, Ewertz M, Tufaro AP, Califano JA, Ringel MD, Zeiger MA, Sidransky D, Ladenson PW. BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer. J Clin Endocrinol Metab. 2005 Dec; 90(12):6373-9. PMID: 16174717.
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    232. Reddy AN, Eisele DW, Forastiere AA, Lee DJ, Westra WH, Califano JA. Neck dissection followed by radiotherapy or chemoradiotherapy for small primary oropharynx carcinoma with cervical metastasis. Laryngoscope. 2005 Jul; 115(7):1196-200. PMID: 15995506.
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    233. Carvalho AL, Nishimoto IN, Califano JA, Kowalski LP. Trends in incidence and prognosis for head and neck cancer in the United States: a site-specific analysis of the SEER database. Int J Cancer. 2005 May 01; 114(5):806-16. PMID: 15609302.
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    234. Russo AL, Thiagalingam A, Pan H, Califano J, Cheng KH, Ponte JF, Chinnappan D, Nemani P, Sidransky D, Thiagalingam S. Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression of lung cancer. Clin Cancer Res. 2005 Apr 01; 11(7):2466-70. PMID: 15814621.
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    235. Benoit NE, Goldenberg D, Deng SX, Rosenbaum E, Cohen Y, Califano JA, Shackelford WH, Wang XB, Sidransky D. Colorimetric approach to high-throughput mutation analysis. Biotechniques. 2005 Apr; 38(4):635-9. PMID: 15884682.
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    236. Jiang WW, Masayesva B, Zahurak M, Carvalho AL, Rosenbaum E, Mambo E, Zhou S, Minhas K, Benoit N, Westra WH, Alberg A, Sidransky D, Koch W, Califano J. Increased mitochondrial DNA content in saliva associated with head and neck cancer. Clin Cancer Res. 2005 Apr 01; 11(7):2486-91. PMID: 15814624.
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    237. Masasyesva BG, Tong BC, Brock MV, Pilkington T, Goldenberg D, Sidransky D, Harden S, Westra WH, Califano J. Molecular margin analysis predicts local recurrence after sublobar resection of lung cancer. Int J Cancer. 2005 Mar 01; 113(6):1022-5. PMID: 15515012.
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    238. Pan H, Califano J, Ponte JF, Russo AL, Cheng KH, Thiagalingam A, Nemani P, Sidransky D, Thiagalingam S. Loss of heterozygosity patterns provide fingerprints for genetic heterogeneity in multistep cancer progression of tobacco smoke-induced non-small cell lung cancer. Cancer Res. 2005 Mar 01; 65(5):1664-9. PMID: 15753360.
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    239. Pilkington TM, Zinreich J, Califano JA. Radiology quiz case 1. Benign parotid cyst with associated facial paralysis. Arch Otolaryngol Head Neck Surg. 2005 Feb; 131(2):178, 182-3. PMID: 15723956.
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    240. Wu G, Osada M, Guo Z, Fomenkov A, Begum S, Zhao M, Upadhyay S, Xing M, Wu F, Moon C, Westra WH, Koch WM, Mantovani R, Califano JA, Ratovitski E, Sidransky D, Trink B. DeltaNp63alpha up-regulates the Hsp70 gene in human cancer. Cancer Res. 2005 Feb 01; 65(3):758-66. PMID: 15705872.
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    241. Westra WH, Califano J. Toward early oral cancer detection using gene expression profiling of saliva: a thoroughfare or dead end? Clin Cancer Res. 2004 Dec 15; 10(24):8130-1. PMID: 15623585.
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    242. Kim MM, Clinger JD, Masayesva BG, Ha PK, Zahurak ML, Westra WH, Califano JA. Mitochondrial DNA quantity increases with histopathologic grade in premalignant and malignant head and neck lesions. Clin Cancer Res. 2004 Dec 15; 10(24):8512-5. PMID: 15623632.
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    243. Jiang WW, Califano J. Mitochondrial mutations and nasopharyngeal carcinoma. Cancer Biol Ther. 2004 Dec; 3(12):1275-6. PMID: 15662125.
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    244. Kim MM, Califano JA. Molecular pathology of head-and-neck cancer. Int J Cancer. 2004 Nov 20; 112(4):545-53. PMID: 15382034.
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    245. Goldenberg D, Rosenbaum E, Argani P, Wistuba II, Sidransky D, Thuluvath PJ, Hidalgo M, Califano J, Maitra A. The V599E BRAF mutation is uncommon in biliary tract cancers. Mod Pathol. 2004 Nov; 17(11):1386-91. PMID: 15181454.
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    246. Sirianni N, Ha PK, Oelke M, Califano J, Gooding W, Westra W, Whiteside TL, Koch WM, Schneck JP, DeLeo A, Ferris RL. Effect of human papillomavirus-16 infection on CD8+ T-cell recognition of a wild-type sequence p53264-272 peptide in patients with squamous cell carcinoma of the head and neck. Clin Cancer Res. 2004 Oct 15; 10(20):6929-37. PMID: 15501971.
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    247. Tokumaru Y, Yamashita K, Osada M, Nomoto S, Sun DI, Xiao Y, Hoque MO, Westra WH, Califano JA, Sidransky D. Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing. Cancer Res. 2004 Sep 01; 64(17):5982-7. PMID: 15342377.
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    248. Hoque MO, Begum S, Topaloglu O, Jeronimo C, Mambo E, Westra WH, Califano JA, Sidransky D. Quantitative detection of promoter hypermethylation of multiple genes in the tumor, urine, and serum DNA of patients with renal cancer. Cancer Res. 2004 Aug 01; 64(15):5511-7. PMID: 15289362.
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    249. Ha PK, Califano JA. The role of human papillomavirus in oral carcinogenesis. Crit Rev Oral Biol Med. 2004 Jul 01; 15(4):188-96. PMID: 15284184.
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    250. Goldenberg D, Benoit NE, Begum S, Westra WH, Cohen Y, Koch WM, Sidransky D, Califano JA. Epstein-Barr virus in head and neck cancer assessed by quantitative polymerase chain reaction. Laryngoscope. 2004 Jun; 114(6):1027-31. PMID: 15179207.
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    251. Masayesva BG, Ha P, Garrett-Mayer E, Pilkington T, Mao R, Pevsner J, Speed T, Benoit N, Moon CS, Sidransky D, Westra WH, Califano J. Gene expression alterations over large chromosomal regions in cancers include multiple genes unrelated to malignant progression. Proc Natl Acad Sci U S A. 2004 Jun 08; 101(23):8715-20. PMID: 15155901; PMCID: PMC423261.
    252. Maitra A, Cohen Y, Gillespie SE, Mambo E, Fukushima N, Hoque MO, Shah N, Goggins M, Califano J, Sidransky D, Chakravarti A. The Human MitoChip: a high-throughput sequencing microarray for mitochondrial mutation detection. Genome Res. 2004 May; 14(5):812-9. PMID: 15123581; PMCID: PMC479107.
    253. Tong BC, Dhir K, Ha PK, Westra WH, Alter BP, Sidransky D, Koch WM, Califano JA. Use of single nucleotide polymorphism arrays to identify a novel region of loss on chromosome 6q in squamous cell carcinomas of the oral cavity. Head Neck. 2004 Apr; 26(4):345-52. PMID: 15054738.
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    254. Harden SV, Thomas DC, Benoit N, Minhas K, Westra WH, Califano JA, Koch W, Sidransky D. Real-time gap ligase chain reaction: a rapid semiquantitative assay for detecting p53 mutation at low levels in surgical margins and lymph nodes from resected lung and head and neck tumors. Clin Cancer Res. 2004 Apr 01; 10(7):2379-85. PMID: 15073114.
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    255. Goldenberg D, Harden S, Masayesva BG, Ha P, Benoit N, Westra WH, Koch WM, Sidransky D, Califano JA. Intraoperative molecular margin analysis in head and neck cancer. Arch Otolaryngol Head Neck Surg. 2004 Jan; 130(1):39-44. PMID: 14732766.
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    256. Sidransky D, Irizarry R, Califano JA, Li X, Ren H, Benoit N, Mao L. Serum protein MALDI profiling to distinguish upper aerodigestive tract cancer patients from control subjects. J Natl Cancer Inst. 2003 Nov 19; 95(22):1711-7. PMID: 14625262.
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    257. Reddy AN, Jiang WW, Kim M, Benoit N, Taylor R, Clinger J, Sidransky D, Califano JA. Death-associated protein kinase promoter hypermethylation in normal human lymphocytes. Cancer Res. 2003 Nov 15; 63(22):7694-8. PMID: 14633692.
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    258. Minhas KM, Singh B, Jiang WW, Sidransky D, Califano JA. Spindle assembly checkpoint defects and chromosomal instability in head and neck squamous cell carcinoma. Int J Cancer. 2003 Oct 20; 107(1):46-52. PMID: 12925955.
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    259. Ha PK, Benoit NE, Yochem R, Sciubba J, Zahurak M, Sidransky D, Pevsner J, Westra WH, Califano J. A transcriptional progression model for head and neck cancer. Clin Cancer Res. 2003 Aug 01; 9(8):3058-64. PMID: 12912957.
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    260. Wu G, Nomoto S, Hoque MO, Dracheva T, Osada M, Lee CC, Dong SM, Guo Z, Benoit N, Cohen Y, Rechthand P, Califano J, Moon CS, Ratovitski E, Jen J, Sidransky D, Trink B. DeltaNp63alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and development. Cancer Res. 2003 May 15; 63(10):2351-7. PMID: 12750249.
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    261. Xing M, Usadel H, Cohen Y, Tokumaru Y, Guo Z, Westra WB, Tong BC, Tallini G, Udelsman R, Califano JA, Ladenson PW, Sidransky D. Methylation of the thyroid-stimulating hormone receptor gene in epithelial thyroid tumors: a marker of malignancy and a cause of gene silencing. Cancer Res. 2003 May 01; 63(9):2316-21. PMID: 12727856.
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    262. Tong BC, Ha PK, Dhir K, Xing M, Westra WH, Sidransky D, Califano JA. Mitochondrial DNA alterations in thyroid cancer. J Surg Oncol. 2003 Mar; 82(3):170-3. PMID: 12619060.
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    263. Foster SE, Vaughan RD, Foster WH, Califano JA. Alcohol consumption and expenditures for underage drinking and adult excessive drinking. JAMA. 2003 Feb 26; 289(8):989-95. PMID: 12597750.
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    264. Califano J, Cordeiro PG, Disa JJ, Hidalgo DA, DuMornay W, Bilsky MH, Gutin PH, Shah JP, Kraus DH. Anterior cranial base reconstruction using free tissue transfer: changing trends. Head Neck. 2003 Feb; 25(2):89-96. PMID: 12509790.
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    265. Ha PK, Califano JA. The molecular biology of mucosal field cancerization of the head and neck. Crit Rev Oral Biol Med. 2003; 14(5):363-9. PMID: 14530304.
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    266. Earnest L, Byrne P, Califano J. Massive facial angiofibroma in a patient with tuberous sclerosis. Otolaryngol Head Neck Surg. 2003 Jan; 128(1):151-3. PMID: 12574776.
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    267. Ha PK, Pilkington TA, Westra WH, Sciubba J, Sidransky D, Califano JA. Progression of microsatellite instability from premalignant lesions to tumors of the head and neck. Int J Cancer. 2002 Dec 20; 102(6):615-7. PMID: 12448003.
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    268. Goldstein B, Westra WH, Califano J. Multifocal papillary thyroid carcinoma arising in a lingual thyroid: a case report. Arch Otolaryngol Head Neck Surg. 2002 Oct; 128(10):1198-200. PMID: 12365894.
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    269. Ha PK, Califano JA. The molecular biology of laryngeal cancer. Otolaryngol Clin North Am. 2002 Oct; 35(5):993-1012. PMID: 12587244.
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    270. Ansari-Lari MA, Hoque MO, Califano J, Westra WH. Immunohistochemical p53 expression patterns in sarcomatoid carcinomas of the upper respiratory tract. Am J Surg Pathol. 2002 Aug; 26(8):1024-31. PMID: 12170089.
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    271. Ha PK, Tong BC, Westra WH, Sanchez-Cespedes M, Parrella P, Zahurak M, Sidransky D, Califano JA. Mitochondrial C-tract alteration in premalignant lesions of the head and neck: a marker for progression and clonal proliferation. Clin Cancer Res. 2002 Jul; 8(7):2260-5. PMID: 12114429.
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    272. Patturajan M, Nomoto S, Sommer M, Fomenkov A, Hibi K, Zangen R, Poliak N, Califano J, Trink B, Ratovitski E, Sidransky D. DeltaNp63 induces beta-catenin nuclear accumulation and signaling. Cancer Cell. 2002 May; 1(4):369-79. PMID: 12086851.
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    273. Ha PK, Pai SI, Westra WH, Gillison ML, Tong BC, Sidransky D, Califano JA. Real-time quantitative PCR demonstrates low prevalence of human papillomavirus type 16 in premalignant and malignant lesions of the oral cavity. Clin Cancer Res. 2002 May; 8(5):1203-9. PMID: 12006539.
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    274. Spafford MF, Koch WM, Reed AL, Califano JA, Xu LH, Eisenberger CF, Yip L, Leong PL, Wu L, Liu SX, Jerónimo C, Westra WH, Sidransky D. Detection of head and neck squamous cell carcinoma among exfoliated oral mucosal cells by microsatellite analysis. Clin Cancer Res. 2001 Mar; 7(3):607-12. PMID: 11297256.
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    275. Rosas SL, Koch W, da Costa Carvalho MG, Wu L, Califano J, Westra W, Jen J, Sidransky D. Promoter hypermethylation patterns of p16, O6-methylguanine-DNA-methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients. Cancer Res. 2001 Feb 01; 61(3):939-42. PMID: 11221887.
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    276. Shah SI, Yip L, Greenberg B, Califano JA, Chow J, Eisenberger CF, Lee DJ, Sewell DA, Reed AL, Lango M, Jen J, Koch WM, Sidransky D. Two distinct regions of loss on chromosome arm 4q in primary head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2000 Sep; 126(9):1073-6. PMID: 10979119.
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    277. Califano J, Westra WH, Meininger G, Corio R, Koch WM, Sidransky D. Genetic progression and clonal relationship of recurrent premalignant head and neck lesions. Clin Cancer Res. 2000 Feb; 6(2):347-52. PMID: 10690509.
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    278. Califano J, Koch W, Sidransky D, Westra WH. Inverted sinonasal papilloma : a molecular genetic appraisal of its putative status as a Precursor to squamous cell carcinoma. Am J Pathol. 2000 Jan; 156(1):333-7. PMID: 10623682.
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    279. Califano J, Eisele DW. Benign salivary gland neoplasms. Otolaryngol Clin North Am. 1999 Oct; 32(5):861-73. PMID: 10477792.
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    280. Califano J, Miller S, Frodel J. Treatment of occipital acne keloidalis by excision followed by secondary intention healing. Arch Facial Plast Surg. 1999 Oct-Dec; 1(4):308-11. PMID: 10937121.
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    281. Califano J, Leong PL, Koch WM, Eisenberger CF, Sidransky D, Westra WH. Second esophageal tumors in patients with head and neck squamous cell carcinoma: an assessment of clonal relationships. Clin Cancer Res. 1999 Jul; 5(7):1862-7. PMID: 10430093.
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    282. Califano J, Westra WH, Koch W, Meininger G, Reed A, Yip L, Boyle JO, Lonardo F, Sidransky D. Unknown primary head and neck squamous cell carcinoma: molecular identification of the site of origin. J Natl Cancer Inst. 1999 Apr 07; 91(7):599-604. PMID: 10203278.
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    283. Califano JA. Physician-assisted living. America (NY). 1998 Nov 14; 179(15):10-2. PMID: 11660567.
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    284. Califano J, Bhatti NI, Niparko JK. Imaging quiz case 2. Jugular bulb dehiscence. Arch Otolaryngol Head Neck Surg. 1998 Sep; 124(9):1047, 1049-50. PMID: 9738823.
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    285. Westra WH, McMurray JS, Califano J, Flint PW, Corio RL. Squamous cell carcinoma of the tongue associated with cinnamon gum use: a case report. Head Neck. 1998 Aug; 20(5):430-3. PMID: 9663672.
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    286. Califano JA. Substance abuse and addiction--the need to know. Am J Public Health. 1998 Jan; 88(1):9-11. PMID: 9583902.
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    287. Califano JA. PAL--the counterweight to physician assisted suicide. Conn Med. 1997 Dec; 61(12):783-4. PMID: 9465461.
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    288. Ahrendt SA, Yang SC, Wu L, Westra WH, Jen J, Califano JA, Sidransky D. Comparison of oncogene mutation detection and telomerase activity for the molecular staging of non-small cell lung cancer. Clin Cancer Res. 1997 Jul; 3(7):1207-14. PMID: 9815801.
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    289. Lee DJ, Koch WM, Yoo G, Lango M, Reed A, Califano J, Brennan JA, Westra WH, Zahurak M, Sidransky D. Impact of chromosome 14q loss on survival in primary head and neck squamous cell carcinoma. Clin Cancer Res. 1997 Apr; 3(4):501-5. PMID: 9815712.
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    290. Califano JA, Johns MM, Westra WH, Lango MN, Eisele D, Saji M, Zeiger MA, Udelsman R, Koch WM, Sidransky D. An allelotype of papillary thyroid cancer. Int J Cancer. 1996 Dec 20; 69(6):442-4. PMID: 8980243.
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    291. Califano J, Ahrendt SA, Meininger G, Westra WH, Koch WM, Sidransky D. Detection of telomerase activity in oral rinses from head and neck squamous cell carcinoma patients. Cancer Res. 1996 Dec 15; 56(24):5720-2. PMID: 8971181.
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    292. Reed AL, Califano J, Cairns P, Westra WH, Jones RM, Koch W, Ahrendt S, Eby Y, Sewell D, Nawroz H, Bartek J, Sidransky D. High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma. Cancer Res. 1996 Aug 15; 56(16):3630-3. PMID: 8705996.
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    293. Califano J, van der Riet P, Westra W, Nawroz H, Clayman G, Piantadosi S, Corio R, Lee D, Greenberg B, Koch W, Sidransky D. Genetic progression model for head and neck cancer: implications for field cancerization. Cancer Res. 1996 Jun 01; 56(11):2488-92. PMID: 8653682.
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    294. Johns MM, Westra WH, Califano JA, Eisele D, Koch WM, Sidransky D. Allelotype of salivary gland tumors. Cancer Res. 1996 Mar 01; 56(5):1151-4. PMID: 8640776.
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    295. Califano JA. The wrong way to stay slim. N Engl J Med. 1995 Nov 02; 333(18):1214-6. PMID: 7565980.
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    296. Cairns P, Polascik TJ, Eby Y, Tokino K, Califano J, Merlo A, Mao L, Herath J, Jenkins R, Westra W, Rutter JL, Buckler A, Gabrielson E, Tockman M, Cho KR, Hedrick L, Bova GS, Isaacs W, Koch W, Schwab D, Sidransky D. Frequency of homozygous deletion at p16/CDKN2 in primary human tumours. Nat Genet. 1995 Oct; 11(2):210-2. PMID: 7550353.
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    297. Califano JA. Busting the physicians' monopoly. As I see it. Am Nurse. 1995 Jun; 27(4):5, 7. PMID: 7668453.
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    298. Califano JA. The dangers of discovery. America (NY). 1995 Jan 14; 172(1):8-11. PMID: 11660146.
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    299. Fox K, Merrill JC, Chang HH, Califano JA. Estimating the costs of substance abuse to the Medicaid hospital care program. Am J Public Health. 1995 Jan; 85(1):48-54. PMID: 7832261.
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    300. Califano JA. Revealing the link between campaign financing and deaths caused by tobacco. JAMA. 1994 Oct 19; 272(15):1217-8. PMID: 7933353.
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    301. Califano JA. Joseph A. Califano Jr. A former HEW secretary looks at health care reform. Interview by Terese Hudson. Hosp Health Netw. 1993 Sep 05; 67(17):56. PMID: 8353567.
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    302. Califano JA. The nurse as a revolutionary. Chart. 1992 Nov; 89(9):3-5. PMID: 1477908.
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    303. Califano JA. Rationing health care: the unnecessary solution. Univ PA Law Rev. 1992 May; 140(5):1525-38. PMID: 11651590.
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    304. Wellstein A, Zugmaier G, Califano JA, Kern F, Paik S, Lippman ME. Tumor growth dependent on Kaposi's sarcoma-derived fibroblast growth factor inhibited by pentosan polysulfate. J Natl Cancer Inst. 1991 May 15; 83(10):716-20. PMID: 1708834.
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    305. Califano JA. The best hope. While Congress may see its best hope in standards of care, employers and providers would do well to take the initiative. Health Manage Q. 1991; 13(2):24-6. PMID: 10111734.
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    306. Califano JA. The Chrysler experience, and forecasts. Consultant. 1989 Jan; 29(1):58-60, 63, 66. PMID: 10291549.
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    307. Califano JA. Where is America's health care revolution going?. Interview by C. Burns Roehrig. Internist. 1988 Sep; 29(8):16-8, 19, 22. PMID: 10290352.
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    308. Califano JA. Guiding the forces of the health care revolution. Nurs Health Care. 1987 Sep; 8(7):401-4. PMID: 3696513.
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    309. Califano JA. America's health care revolution: health promotion and disease prevention. J Am Diet Assoc. 1987 Apr; 87(4):437-40. PMID: 3559002.
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    310. Califano JA. Who lives? Who dies? Who pays? America's health care revolution. Vital Speeches Day. 1986 Jun 01; 52(16):485-9. PMID: 10277259.
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    311. Califano JA. Who will lead the revolution in American health care? Second Opin. 1986; (2):92-105. PMID: 10281526.
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    312. Califano JA. Luther Terry, MD, 1911-1985. A caring, courageous man. N Y State J Med. 1985 Jul; 85(7):293. PMID: 3900826.
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    313. Califano JA. Obstacles to the prevention of teenage smoking. Interview by Alan Blum. N Y State J Med. 1985 Jul; 85(7):360-2. PMID: 3862995.
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    314. Califano JA. The health cost of doing business. Health Matrix. 1985; 3(3):32-6. PMID: 10280936.
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    315. Califano JA. Moral leadership and partisanship. America (NY). 1984 Sep 29; 151(8):164-5. PMID: 11658534.
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    316. Califano J. The great American shell game: controlling healthcare costs. Hosp Health Serv Adm. 1984 Sep-Oct; 29(5):61-73. PMID: 10310862.
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    317. Califano JA. Chrysler perspective. Group Pract J. 1984 May-Jun; 33(3):6, 8, 10. PMID: 10270099.
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    318. Califano JA. The Chrysler story: how an ailing American firm is tackling health care cost problem. Rev Fed Am Hosp. 1983 Jul-Aug; 16(4):12, 16-9. PMID: 10260803.
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    319. Califano JA. The infighting over abortion: an administration divided. Washington Post. 1981 May 19; A1, A6. PMID: 11647323.
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    320. Califano JA. Califano and abortion: questions of conscience. Washington Post. 1981 May 18; A1, A12. PMID: 11647322.
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    321. Califano JA. Presentation by Joseph A. Califano, former Secretary, Department of Health, Education, and Welfare, before the National Council on Alcoholism. Alcohol Clin Exp Res. 1979 Oct; 3(4):368-73. PMID: 391090.
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    322. Califano JA. Preview of Carter's national health plan. US News World Rep. 1979 Jun 11; 86(23):28-9. PMID: 10242405.
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    323. Califano JA. Califano answers back. Interview by Mary Hager. Newsweek. 1979 May 28; 93(22):37. PMID: 10241573.
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    324. Califano JA. Social security and the changing roles of men and women. J Tenn Med Assoc. 1979 Apr; 72(4):291-4. PMID: 470369.
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    325. Califano JA. Managing the world's largest bureaucracy. OH. 1979 Jan; 23(1):12-3. PMID: 10239884.
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    326. Califano JA. The government-medical education partnership. J Med Educ. 1979 Jan; 54(1):19-24. PMID: 762677.
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    327. Califano JA. Standards to judge productivity slated. US Med. 1978 Nov 15; 14(22):1, 26. PMID: 10239596.
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    328. Califano JA. A positive health strategy: a new commitment to wellness. Am Lung Assoc Bull. 1978 Nov; 64(9):5-10. PMID: 10238960.
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    329. Califano JA. Prevention in health care: an agenda for the next 100 years. Public Health Rep. 1978 Nov-Dec; 93(6):600-1. PMID: 715159.
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    330. Califano J. Secretary Califano pledges upport for hospice movement. Aging. 1978 Nov-Dec; (289-290):20-1. PMID: 10240344.
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    331. Califano JA. Califano and Kennedy take sides on national health plan. Health Care Week. 1978 Oct 02; 2(13):8. PMID: 10238781.
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    332. Califano JA. A strategy for future federal support of biomedical research. Clin Res. 1978 Oct; 26(5):317-21. PMID: 10238682.
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    333. Califano JA. Development of a multi-year strategy for support of health research. Ala J Med Sci. 1978 Oct; 15(4):332-7. PMID: 747205.
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    334. Califano JA. Remarks of Joseph A. Califano, Jr. Secretary of Health, Education, and Welfare at the National HMO conference. J Dent Educ. 1978 Oct; 42(10):556-9. PMID: 102672.
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    335. Califano JA. U.S. policy for the aging--a commitment to ourselves. Natl J (Wash). 1978 Sep 30; 10(39):1575-81. PMID: 10238421.
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    336. Califano JA. The aging of America: questions for the four-generation society. Long Term Care Health Serv Adm Q. 1978 Sep; 2(3):250-60. PMID: 10238839.
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    337. Califano J. Califano proposes progressive policies for nation's elderly. Aging. 1978 Jul-Aug; (285-286):1-4. PMID: 10238391.
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    338. Califano JA. Statement of Secretary Joseph A. Califano, Jr. Department of Health, Education, and Welfare. J Environ Pathol Toxicol. 1978 May-Jun; 1(5):727-9. PMID: 722212.
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    339. Califano JA. HEW's Califano urges debate on moral issues. Hosp Prog. 1978 Mar; 59(3):71-2, 84. PMID: 631814.
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    340. Califano JA. The big medical questions: not for experts alone. Med World News. 1978 Feb 06; 19(3):111. PMID: 10306397.
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    341. Califano JA. Sterilization. Forum (Wash). 1978; 2(2):7-13. PMID: 11643514.
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    342. Califano JA. National health care planning: the health maintenance organization. Vital Speeches Day. 1977 Dec 01; 44(3):112-4. PMID: 10305848.
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    343. Califano JA. Remarks of Joseph A. Califano, Jr. Secretary of Health, Education, and Welfare before the NRA National Conference Washington, D.C. September 10, 1977. J Rehabil. 1977 Nov-Dec; 43(5):31-3. PMID: 144186.
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    344. Califano JA. What's wrong with U.S. health care. J Am Health Care Assoc. 1977 Sep; 3(5):50-2. PMID: 10247289.
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    345. Califano JA. School health message. J Sch Health. 1977 Sep; 47(7):395-6. PMID: 587812.
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    346. Califano JA. School health message. J Sch Health. 1977 Jun; 47(6):334-5. PMID: 586410.
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