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Joseph Califano

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentRadiation Medicine and Applied Science
Address9500 Gilman Drive #0803
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Optimizing an assay for high risk HPV DNA in body fluids
    NIH/NCI UH2CA211396May 12, 2017 - Apr 30, 2019
    Role: Principal Investigator
    A novel point of care test for oral and oropharyngeal cancer risk
    NIH/NCI R01CA204264Jan 3, 2017 - Dec 31, 2021
    Role: Principal Investigator
    Howard University Summer Research Experience Program in Oral Health Disparity for Underrepresented Racial and Ethnic Students
    NIH/NIDCR R25DE025778Jan 1, 2016 - Dec 31, 2020
    Role: Principal Investigator
    (2/2) Howard University/Johns Hopkins Partnership in HPV-Related Cancer Research
    NIH P20CA192988Sep 20, 2014 - Aug 31, 2018
    Role: Co-Investigator
    Epigenetic Biomarker Discovery in HPV Related HNSCC
    NIH/NIDCR R01DE023347Apr 1, 2013 - Mar 31, 2018
    Role: Principal Investigator
    Validation of epigenetic biomarkers of head and neck cancer progression--OLD
    NIH/NIDCR RC2DE020789Sep 25, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Integrative Pathway Analysis of Epigenomic/transcriptional Alteration in HNSCC
    NIH/NIDCR RC1DE020324Sep 22, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Tadalafil Induced Modulation of Immune Response in HNSCC
    NIH/NCI R21CA135635Jan 1, 2009 - Dec 31, 2012
    Role: Principal Investigator
    Cetuximab for Treatment of High-risk Pre-malignant Upper Aerodigestive Lesions
    NIH/NCI R21CA126055Feb 1, 2008 - Jan 31, 2012
    Role: Principal Investigator
    HU/JHU Head and Neck Cancer Translational Research and *
    NIH/NCI P20CA118782Sep 30, 2005 - Aug 31, 2009
    Role: Principal Investigator
    Molecular Anatomy of Mitochondria in HNSC
    NIH/NIDCR R01DE015939Apr 1, 2004 - Feb 28, 2008
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bryant AK, Sojourner EJ, Vitzthum LK, Zakeri K, Shen H, Nguyen C, Murphy JD, Califano J, Cohen EEW, Mell LK. Prognostic Role of p16 in Nonoropharyngeal Head and Neck Cancer. J Natl Cancer Inst. 2018 Jun 05. PMID: 29878161.
      View in: PubMed
    2. Stein-O'Brien G, Kagohara LT, Li S, Thakar M, Ranaweera R, Ozawa H, Cheng H, Considine M, Schmitz S, Favorov AV, Danilova LV, Califano J, Izumchenko E, Gaykalova DA, Chung CH, Fertig EJ. Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance. Genome Med. 2018 May 23; 10(1):37. PMID: 29792227.
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    3. Pang J, Tringale KR, Tapia VJ, Panuganti BA, Qualliotine JR, Jafari A, Haft SJ, Friedman LS, Furnish T, Brumund KT, Califano J, Coffey CS. Opioid prescribing practices in patients undergoing surgery for oral cavity cancer. Laryngoscope. 2018 May 14. PMID: 29756393.
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    4. Moss W, Finegersh A, Pang J, Califano J, Coffey CS, Orosco R, Brumund KT. Needle biopsy of routine thyroid nodules should be performed using a capillary action technique with 24-27 gauge needles: a systematic review and meta-analysis. Thyroid. 2018 May 10. PMID: 29742978.
      View in: PubMed
    5. Bhat MY, Advani J, Rajagopalan P, Patel K, Nanjappa V, Solanki HS, Patil AH, Bhat FA, Mathur PP, Nair B, Prasad TSK, Califano J, Sidransky D, Gowda H, Chatterjee A. Cigarette smoke and chewing tobacco alter expression of different sets of miRNAs in oral keratinocytes. Sci Rep. 2018 May 04; 8(1):7040. PMID: 29728663.
      View in: PubMed
    6. Rajagopalan P, Patel K, Jain AP, Nanjappa V, Datta KK, Subbannayya T, Mangalaparthi KK, Kumari A, Manoharan M, Karunakaran C, Murugan S, Nair B, Prasad TSK, Mathur PP, Gupta R, Gupta R, Khanna-Gupta A, Califano J, Sidransky D, Gowda H, Chatterjee A. Molecular alterations associated with chronic exposure to cigarette smoke and chewing tobacco in normal oral keratinocytes. Cancer Biol Ther. 2018 May 03; 1-36. PMID: 29723088.
      View in: PubMed
    7. Orosco RK, Tapia VJ, Califano J, Clary B, Cohen EEW, Kane C, Lippman SM, Messer K, Molinolo A, Murphy JD, Pang J, Sacco A, Tringale KR, Wallace A, Nguyen QT. Positive Surgical Margins in the 10 Most Common Solid Cancers. Sci Rep. 2018 Apr 09; 8(1):5686. PMID: 29632347.
      View in: PubMed
    8. Rajagopalan P, Nanjappa V, Patel K, Jain AP, Mangalaparthi KK, Patil AH, Nair B, Mathur PP, Keshava Prasad TS, Califano J, Sidransky D, Gowda H, Chatterjee A. Role of protein kinase N2 (PKN2) in cigarette smoke-mediated oncogenic transformation of oral cells. J Cell Commun Signal. 2018 Feb 26. PMID: 29480433.
      View in: PubMed
    9. Karia PS, Morgan FC, Califano J, Schmults CD. Comparison of Tumor Classifications for Cutaneous Squamous Cell Carcinoma of the Head and Neck in the 7th vs 8th Edition of the AJCC Cancer Staging Manual. JAMA Dermatol. 2018 Feb 01; 154(2):175-181. PMID: 29261835.
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    10. Afsari B, Guo T, Considine M, Florea L, Kagohara LT, Stein-O'Brien GL, Kelley D, Flam E, Zambo KD, Ha PK, Geman D, Ochs MF, Califano J, Gaykalova DA, Favorov AV, Fertig EJ. Splice Expression Variation Analysis (SEVA) for Inter-tumor Heterogeneity of Gene Isoform Usage in Cancer. Bioinformatics. 2018 Jan 12. PMID: 29342249.
      View in: PubMed
    11. Krishnan AR, Qu Y, Li PX, Zou AE, Califano J, Wang-Rodriguez J, Ongkeko WM. Computational methods reveal novel functionalities of PIWI-interacting RNAs in human papillomavirus-induced head and neck squamous cell carcinoma. Oncotarget. 2018 Jan 12; 9(4):4614-4624. PMID: 29435129.
      View in: PubMed
    12. Pang J, Tringale KR, Tapia VJ, Moss WJ, May ME, Furnish T, Barnachea L, Brumund KT, Sacco AG, Weisman RA, Nguyen QT, Harris JP, Coffey CS, Califano J. Chronic Opioid Use Following Surgery for Oral Cavity Cancer. JAMA Otolaryngol Head Neck Surg. 2017 Dec 01; 143(12):1187-1194. PMID: 28445584.
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    13. Fukusumi T, Guo TW, Sakai A, Ando M, Ren S, Haft S, Liu C, Amornphimoltham P, Gutkind JS, Califano J. The NOTCH4-HEY1 Pathway Induces Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2018 Feb 01; 24(3):619-633. PMID: 29146722.
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    14. Finegersh A, Kulich S, Guo T, Favorov AV, Fertig EJ, Danilova LV, Gaykalova DA, Califano J, Duvvuri U. DNA methylation regulates TMEM16A/ANO1 expression through multiple CpG islands in head and neck squamous cell carcinoma. Sci Rep. 2017 Nov 09; 7(1):15173. PMID: 29123240.
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    15. Quon H, Vapiwala N, Forastiere A, Kennedy EB, Adelstein DJ, Boykin H, Califano J, Holsinger FC, Nussenbaum B, Rosenthal DI, Siu LL, Waldron JN. Radiation Therapy for Oropharyngeal Squamous Cell Carcinoma: American Society of Clinical Oncology Endorsement of the American Society for Radiation Oncology Evidence-Based Clinical Practice Guideline. J Clin Oncol. 2017 Dec 20; 35(36):4078-4090. PMID: 29064744.
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    16. Kelley DZ, Flam EL, Izumchenko E, Danilova LV, Wulf HA, Guo T, Singman DA, Afsari B, Skaist AM, Considine M, Welch JA, Stavrovskaya E, Bishop JA, Westra WH, Khan Z, Koch WM, Sidransky D, Wheelan SJ, Califano J, Favorov AV, Fertig EJ, Gaykalova DA. Integrated Analysis of Whole-Genome ChIP-Seq and RNA-Seq Data of Primary Head and Neck Tumor Samples Associates HPV Integration Sites with Open Chromatin Marks. Cancer Res. 2017 12 01; 77(23):6538-6550. PMID: 28947419.
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    17. Guo T, Sakai A, Afsari B, Considine M, Danilova L, Favorov AV, Yegnasubramanian S, Kelley DZ, Flam E, Ha PK, Khan Z, Wheelan SJ, Gutkind JS, Fertig EJ, Gaykalova DA, Califano J. A Novel Functional Splice Variant of AKT3 Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers. Cancer Res. 2017 10 01; 77(19):5248-5258. PMID: 28733453.
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    18. Krishnan AR, Zheng H, Kwok JG, Qu Y, Zou AE, Korrapati A, Li PX, Califano J, Hovell MF, Wang-Rodriguez J, Ongkeko WM. A comprehensive study of smoking-specific microRNA alterations in head and neck squamous cell carcinoma. Oral Oncol. 2017 Sep; 72:56-64. PMID: 28797462.
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    19. Radhakrishnan A, Nanjappa V, Raja R, Sathe G, Puttamallesh VN, Jain AP, Pinto SM, Balaji SA, Chavan S, Sahasrabuddhe NA, Mathur PP, Kumar MM, Prasad TSK, Santosh V, Sukumar G, Califano J, Rangarajan A, Sidransky D, Pandey A, Gowda H, Chatterjee A. Corrigendum: A dual specificity kinase, DYRK1A, as a potential therapeutic target for head and neck squamous cell carcinoma. Sci Rep. 2017 06 26; 7:46864. PMID: 28650432.
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    20. Messing BP, Ward EC, Lazarus CL, Kim M, Zhou X, Silinonte J, Gold D, Harrer K, Ulmer K, Merritt S, Neuner G, Levine M, Blanco R, Saunders J, Califano J. Prophylactic Swallow Therapy for Patients with Head and Neck Cancer Undergoing Chemoradiotherapy: A Randomized Trial. Dysphagia. 2017 Aug; 32(4):487-500. PMID: 28444488.
      View in: PubMed
    21. Zhao Y, Ling Z, Hao Y, Pang X, Han X, Califano J, Shan L, Gu X. MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma. Oncotarget. 2017 Apr 11; 8(15):25005-25020. PMID: 28212569.
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    22. Gaykalova DA, Zizkova V, Guo T, Tiscareno I, Wei Y, Vatapalli R, Hennessey PT, Ahn J, Danilova L, Khan Z, Bishop JA, Gutkind JS, Koch WM, Westra WH, Fertig EJ, Ochs MF, Califano J. Integrative computational analysis of transcriptional and epigenetic alterations implicates DTX1 as a putative tumor suppressor gene in HNSCC. Oncotarget. 2017 Feb 28; 8(9):15349-15363. PMID: 28146432.
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    23. Tota JE, Anderson WF, Coffey C, Califano J, Cozen W, Ferris RL, St John M, Cohen EE, Chaturvedi AK. Rising incidence of oral tongue cancer among white men and women in the United States, 1973-2012. Oral Oncol. 2017 Apr; 67:146-152. PMID: 28351569.
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    24. Patel MA, Eytan DF, Bishop J, Califano J. Favorable Swallowing Outcomes following Vagus Nerve Sacrifice for Vagal Schwannoma Resection. Otolaryngol Head Neck Surg. 2017 02; 156(2):329-333. PMID: 27899468.
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    25. Rosculet N, Zhou XC, Ha P, Tang M, Levine MA, Neuner G, Califano J. Neutrophil-to-lymphocyte ratio: Prognostic indicator for head and neck squamous cell carcinoma. Head Neck. 2017 04; 39(4):662-667. PMID: 28075517.
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    26. Krishnan AR, Korrapati A, Zou AE, Qu Y, Wang XQ, Califano J, Wang-Rodriguez J, Lippman SM, Hovell MF, Ongkeko WM. Smoking status regulates a novel panel of PIWI-interacting RNAs in head and neck squamous cell carcinoma. Oral Oncol. 2017 Feb; 65:68-75. PMID: 28109471.
      View in: PubMed
    27. Oweida A, Bhatia S, Hirsch K, Calame D, Griego A, Keysar S, Pitts T, Sharma J, Eckhardt G, Jimeno A, Wang XJ, Parkash G, Califano J, Karam SD. Ephrin-B2 overexpression predicts for poor prognosis and response to therapy in solid tumors. Mol Carcinog. 2017 03; 56(3):1189-1196. PMID: 27649287.
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    28. Radhakrishnan A, Nanjappa V, Raja R, Sathe G, Puttamallesh VN, Jain AP, Pinto SM, Balaji SA, Chavan S, Sahasrabuddhe NA, Mathur PP, Kumar MM, Prasad TS, Santosh V, Sukumar G, Califano J, Rangarajan A, Sidransky D, Pandey A, Gowda H, Chatterjee A. A dual specificity kinase, DYRK1A, as a potential therapeutic target for head and neck squamous cell carcinoma. Sci Rep. 2016 10 31; 6:36132. PMID: 27796319.
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    29. Callejas-Valera JL, Iglesias-Bartolome R, Amornphimoltham P, Palacios-Garcia J, Martin D, Califano J, Molinolo AA, Gutkind JS. mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model. Carcinogenesis. 2016 10; 37(10):1014-25. PMID: 27538837.
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    30. D'Souza G, Zhang Y, Merritt S, Gold D, Robbins HA, Buckman V, Gerber J, Eisele DW, Ha P, Califano J, Fakhry C. Patient experience and anxiety during and after treatment for an HPV-related oropharyngeal cancer. Oral Oncol. 2016 09; 60:90-5. PMID: 27531878.
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    31. Sobel RH, Blanco R, Ha PK, Califano J, Kumar R, Richmon JD. Implementation of a comprehensive competency-based transoral robotic surgery training curriculum with ex vivo dissection models. Head Neck. 2016 10; 38(10):1553-63. PMID: 27152633.
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    32. Khan Z, Epstein JB, Marur S, Boyd Gillespie M, Feldman L, Tsai HL, Zhang Z, Wang H, Sciubba J, Ferris RL, Grandis JR, Gibson M, Koch W, Tufano R, Westra W, Tsottles N, Ozawa H, Chung CH, Califano J. Corrigendum to "Cetuximab activity in dysplastic lesions of the upper aerodigestive tract" [Oral Oncol. 53 (2016) 60-66]. Oral Oncol. 2016 Jun; 57:e8. PMID: 27085635.
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    33. Guo T, Gaykalova DA, Considine M, Wheelan S, Pallavajjala A, Bishop JA, Westra WH, Ideker T, Koch WM, Khan Z, Fertig EJ, Califano J. Characterization of functionally active gene fusions in human papillomavirus related oropharyngeal squamous cell carcinoma. Int J Cancer. 2016 07 15; 139(2):373-82. PMID: 26949921.
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    34. Yamaguchi K, Iglesias-Bartolomé R, Wang Z, Callejas-Valera JL, Amornphimoltham P, Molinolo AA, Cohen EE, Califano J, Lippman SM, Luo J, Gutkind JS. A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers. Oncotarget. 2016 Mar 08; 7(10):10696-709. PMID: 26882569; PMCID: PMC4905432.
    35. Stansfield JC, Rusay M, Shan R, Kelton C, Gaykalova DA, Fertig EJ, Califano J, Ochs MF. Toward Signaling-Driven Biomarkers Immune to Normal Tissue Contamination. Cancer Inform. 2016; 15:15-21. PMID: 26884679; PMCID: PMC4750896.
    36. Radhakrishnan A, Nanjappa V, Raja R, Sathe G, Chavan S, Nirujogi RS, Patil AH, Solanki H, Renuse S, Sahasrabuddhe NA, Mathur PP, Prasad TS, Kumar P, Califano J, Sidransky D, Pandey A, Gowda H, Chatterjee A. Dysregulation of splicing proteins in head and neck squamous cell carcinoma. Cancer Biol Ther. 2016; 17(2):219-29. PMID: 26853621; PMCID: PMC4848015 [Available on 02/06/17].
    37. Fakhry C, Qualliotine JR, Zhang Z, Agrawal N, Gaykalova DA, Bishop JA, Subramaniam RM, Koch WM, Chung CH, Eisele DW, Califano J, Viscidi RP. Serum Antibodies to HPV16 Early Proteins Warrant Investigation as Potential Biomarkers for Risk Stratification and Recurrence of HPV-Associated Oropharyngeal Cancer. Cancer Prev Res (Phila). 2016 Feb; 9(2):135-41. PMID: 26701665; PMCID: PMC4811031 [Available on 02/01/17].
    38. Khan Z, Epstein JB, Marur S, Gillespie MB, Feldman L, Tsai HL, Zhang Z, Wang H, Sciubba J, Ferris R, Grandis JR, Gibson M, Koch W, Tufano R, Westra W, Tsottles N, Ozawa H, Chung C, Califano J. Cetuximab activity in dysplastic lesions of the upper aerodigestive tract. Oral Oncol. 2016 Feb; 53:60-6. PMID: 26686755.
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    39. Joseph AW, Guo T, Hur K, Xie Y, Yin L, Califano J, Ha PK, Quon H, Richmon JD, Eisele DW, Agrawal N, Fakhry C. Disease-free survival after salvage therapy for recurrent oropharyngeal squamous cell carcinoma. Head Neck. 2016 04; 38 Suppl 1:E1501-9. PMID: 26558328.
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    40. Gaykalova DA, Vatapalli R, Wei Y, Tsai HL, Wang H, Zhang C, Hennessey PT, Guo T, Tan M, Li R, Ahn J, Khan Z, Westra WH, Bishop JA, Zaboli D, Koch WM, Khan T, Ochs MF, Califano J. Outlier Analysis Defines Zinc Finger Gene Family DNA Methylation in Tumors and Saliva of Head and Neck Cancer Patients. PLoS One. 2015; 10(11):e0142148. PMID: 26544568; PMCID: PMC4636259.
    41. Li RJ, Zhou XC, Fakhry C, Negrin J, Lee G, Ha P, Blanco R, Saunders J, Califano J. Reduction of Pharyngocutaneous Fistulae in Laryngectomy Patients by a Comprehensive Performance Improvement Intervention. Otolaryngol Head Neck Surg. 2015 Dec; 153(6):927-34. PMID: 26519459.
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    42. Nanjappa V, Renuse S, Sathe GJ, Raja R, Syed N, Radhakrishnan A, Subbannayya T, Patil A, Marimuthu A, Sahasrabuddhe NA, Guerrero-Preston R, Somani BL, Nair B, Kundu GC, Prasad TK, Califano J, Gowda H, Sidransky D, Pandey A, Chatterjee A. Chronic exposure to chewing tobacco selects for overexpression of stearoyl-CoA desaturase in normal oral keratinocytes. Cancer Biol Ther. 2015; 16(11):1593-603. PMID: 26391970; PMCID: PMC4846103 [Available on 09/21/16].
    43. Taghipour M, Marcus C, Califano J, Fakhry C, Subramaniam RM. The value of follow-up FDG-PET/CT in the management and prognosis of patients with HPV-positive oropharyngeal squamous cell carcinoma. J Med Imaging Radiat Oncol. 2015 Dec; 59(6):681-6. PMID: 26768092.
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    44. Mydlarz WK, Hennessey PT, Wang H, Carvalho AL, Califano J. Serum biomarkers for detection of head and neck squamous cell carcinoma. Head Neck. 2016 Jan; 38(1):9-14. PMID: 24995714; PMCID: PMC4317379.
    45. Wang Y, Springer S, Mulvey CL, Silliman N, Schaefer J, Sausen M, James N, Rettig EM, Guo T, Pickering CR, Bishop JA, Chung CH, Califano J, Eisele DW, Fakhry C, Gourin CG, Ha PK, Kang H, Kiess A, Koch WM, Myers JN, Quon H, Richmon JD, Sidransky D, Tufano RP, Westra WH, Bettegowda C, Diaz LA, Papadopoulos N, Kinzler KW, Vogelstein B, Agrawal N. Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas. Sci Transl Med. 2015 Jun 24; 7(293):293ra104. PMID: 26109104; PMCID: PMC4587492.
    46. Gaykalova DA, Manola JB, Ozawa H, Zizkova V, Morton K, Bishop JA, Sharma R, Zhang C, Michailidi C, Considine M, Tan M, Fertig EJ, Hennessey PT, Ahn J, Koch WM, Westra WH, Khan Z, Chung CH, Ochs MF, Califano J. NF-?B and stat3 transcription factor signatures differentiate HPV-positive and HPV-negative head and neck squamous cell carcinoma. Int J Cancer. 2015 Oct 15; 137(8):1879-89. PMID: 25857630; PMCID: PMC4629062 [Available on 10/15/16].
    47. Guo T, Califano J. Molecular biology and immunology of head and neck cancer. Surg Oncol Clin N Am. 2015 Jul; 24(3):397-407. PMID: 25979390; PMCID: PMC4435820.
    48. Guo T, Qualliotine JR, Ha PK, Califano J, Kim Y, Saunders JR, Blanco RG, D'Souza G, Zhang Z, Chung CH, Kiess A, Gourin CG, Koch W, Richmon JD, Agrawal N, Eisele DW, Fakhry C. Surgical salvage improves overall survival for patients with HPV-positive and HPV-negative recurrent locoregional and distant metastatic oropharyngeal cancer. Cancer. 2015 Jun 15; 121(12):1977-84. PMID: 25782027; PMCID: PMC4457566.
    49. Lee J, Wysocki PT, Topaloglu O, Maldonado L, Brait M, Begum S, Moon D, Kim MS, Califano J, Sidransky D, Hoque MO, Moon C. Epigenetic silencing of S100A2 in bladder and head and neck cancers. Oncoscience. 2015; 2(4):410-8. PMID: 26097874; PMCID: PMC4468326.
    50. Hauser B, Zhao Y, Pang X, Ling Z, Myers E, Wang P, Califano J, Gu X. Functions of MiRNA-128 on the regulation of head and neck squamous cell carcinoma growth and apoptosis. PLoS One. 2015; 10(3):e0116321. PMID: 25764126; PMCID: PMC4357443.
    51. Rettig EM, Chung CH, Bishop JA, Howard JD, Sharma R, Li RJ, Douville C, Karchin R, Izumchenko E, Sidransky D, Koch W, Califano J, Agrawal N, Fakhry C. Cleaved NOTCH1 Expression Pattern in Head and Neck Squamous Cell Carcinoma Is Associated with NOTCH1 Mutation, HPV Status, and High-Risk Features. Cancer Prev Res (Phila). 2015 Apr; 8(4):287-95. PMID: 25633867; PMCID: PMC4383699.
    52. Califano J, Khan Z, Noonan KA, Rudraraju L, Zhang Z, Wang H, Goodman S, Gourin CG, Ha PK, Fakhry C, Saunders J, Levine M, Tang M, Neuner G, Richmon JD, Blanco R, Agrawal N, Koch WM, Marur S, Weed DT, Serafini P, Borrello I. Tadalafil augments tumor specific immunity in patients with head and neck squamous cell carcinoma. Clin Cancer Res. 2015 Jan 01; 21(1):30-8. PMID: 25564570; PMCID: PMC4329916.
    53. Syed N, Chavan S, Sahasrabuddhe NA, Renuse S, Sathe G, Nanjappa V, Radhakrishnan A, Raja R, Pinto SM, Srinivasan A, Prasad TS, Srikumar K, Gowda H, Santosh V, Sidransky D, Califano J, Pandey A, Chatterjee A. Silencing of high-mobility group box 2 (HMGB2) modulates cisplatin and 5-fluorouracil sensitivity in head and neck squamous cell carcinoma. Proteomics. 2015 Jan; 15(2-3):383-93. PMID: 25327479; PMCID: PMC4528963.
    54. Sun W, Califano J. Sequencing the head and neck cancer genome: implications for therapy. Ann N Y Acad Sci. 2014 Dec; 1333:33-42. PMID: 25440877; PMCID: PMC4329919.
    55. Messing BP, Kim M, Hirata R, Thompson CB, Gebhart S, Sugar EA, Saunders JM, Sciubba J, Califano J. Evaluation of prophylaxis treatment of Candida in alaryngeal patients with tracheoesophageal voice prostheses. Laryngoscope. 2015 May; 125(5):1118-23. PMID: 25418079.
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    56. Choudhary A, Mambo E, Sanford T, Boedigheimer M, Twomey B, Califano J, Hadd A, Oliner KS, Beaudenon S, Latham GJ, Adai AT. Evaluation of an integrated clinical workflow for targeted next-generation sequencing of low-quality tumor DNA using a 51-gene enrichment panel. BMC Med Genomics. 2014 Nov 14; 7:62. PMID: 25395014; PMCID: PMC4241214.
    57. Weed DT, Vella JL, Reis IM, De la Fuente AC, Gomez C, Sargi Z, Nazarian R, Califano J, Borrello I, Serafini P. Tadalafil reduces myeloid-derived suppressor cells and regulatory T cells and promotes tumor immunity in patients with head and neck squamous cell carcinoma. Clin Cancer Res. 2015 Jan 01; 21(1):39-48. PMID: 25320361; PMCID: PMC4322895.
    58. Benson EM, Hirata RM, Thompson CB, Ha PK, Fakhry C, Saunders JR, Califano J, Arnaoutakis D, Levine M, Tang M, Neuner G, Messing BP, Blanco RG. Pharyngocutaneous fistula after total laryngectomy: a single-institution experience, 2001-2012. Am J Otolaryngol. 2015 Jan-Feb; 36(1):24-31. PMID: 25245411; PMCID: PMC4385716.
    59. Ahn SM, Chan JY, Zhang Z, Wang H, Khan Z, Bishop JA, Westra W, Koch WM, Califano J. Saliva and plasma quantitative polymerase chain reaction-based detection and surveillance of human papillomavirus-related head and neck cancer. JAMA Otolaryngol Head Neck Surg. 2014 Sep; 140(9):846-54. PMID: 25078109; PMCID: PMC4313904.
    60. Rathi KS, Gaykalova DA, Hennessey P, Califano J, Ochs MF. Correcting transcription factor gene sets for copy number and promoter methylation variations. Drug Dev Res. 2014 Sep; 75(6):343-7. PMID: 25195578; PMCID: PMC4160810.
    61. Li R, Faden DL, Fakhry C, Langelier C, Jiao Y, Wang Y, Wilkerson MD, Pedamallu CS, Old M, Lang J, Loyo M, Ahn SM, Tan M, Gooi Z, Chan J, Richmon J, Wood LD, Hruban RH, Bishop J, Westra WH, Chung CH, Califano J, Gourin CG, Bettegowda C, Meyerson M, Papadopoulos N, Kinzler KW, Vogelstein B, DeRisi JL, Koch WM, Agrawal N. Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke. Head Neck. 2015 Nov; 37(11):1642-9. PMID: 24954188; PMCID: PMC4272912 [Available on 11/01/16].
    62. Fakhry C, Agrawal N, Califano J, Messing B, Liu J, Saunders J, Ha P, Coquia S, Hamper U, Gillison M, Blanco R. The use of ultrasound in the search for the primary site of unknown primary head and neck squamous cell cancers. Oral Oncol. 2014 Jul; 50(7):640-5. PMID: 24819862; PMCID: PMC4696034.
    63. Guerrero-Preston R, Michailidi C, Marchionni L, Pickering CR, Frederick MJ, Myers JN, Yegnasubramanian S, Hadar T, Noordhuis MG, Zizkova V, Fertig E, Agrawal N, Westra W, Koch W, Califano J, Velculescu VE, Sidransky D. Key tumor suppressor genes inactivated by "greater promoter" methylation and somatic mutations in head and neck cancer. Epigenetics. 2014 Jul; 9(7):1031-46. PMID: 24786473; PMCID: PMC4143405.
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    160. Woo J, Lee J, Chae YK, Kim MS, Baek JH, Park JC, Park MJ, Smith IM, Trink B, Ratovitski E, Lee T, Park B, Jang SJ, Soria JC, Califano J, Sidransky D, Moon C. Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation. Cancer Lett. 2008 Jun 08; 264(1):54-62. PMID: 18423983; PMCID: PMC3074481.
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    164. Zhao M, Mydlarz WK, Zhou S, Califano J. Head and neck cancer cell lines are resistant to mitochondrial-depolarization-induced apoptosis. ORL J Otorhinolaryngol Relat Spec. 2008; 70(4):257-63. PMID: 18483464.
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    167. Kim MS, Lebron C, Nagpal JK, Chae YK, Chang X, Huang Y, Chuang T, Yamashita K, Trink B, Ratovitski EA, Califano J, Sidransky D. Methylation of the DFNA5 increases risk of lymph node metastasis in human breast cancer. Biochem Biophys Res Commun. 2008 May 23; 370(1):38-43. PMID: 18346456; PMCID: PMC3094717.
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    201. Ha PK, Califano J. Promoter methylation and inactivation of tumour-suppressor genes in oral squamous-cell carcinoma. Lancet Oncol. 2006 Jan; 7(1):77-82. PMID: 16389187.
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    228. Goldenberg D, Harden S, Masayesva BG, Ha P, Benoit N, Westra WH, Koch WM, Sidransky D, Califano J. Intraoperative molecular margin analysis in head and neck cancer. Arch Otolaryngol Head Neck Surg. 2004 Jan; 130(1):39-44. PMID: 14732766.
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    229. Sidransky D, Irizarry R, Califano J, Li X, Ren H, Benoit N, Mao L. Serum protein MALDI profiling to distinguish upper aerodigestive tract cancer patients from control subjects. J Natl Cancer Inst. 2003 Nov 19; 95(22):1711-7. PMID: 14625262.
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    230. Reddy AN, Jiang WW, Kim M, Benoit N, Taylor R, Clinger J, Sidransky D, Califano J. Death-associated protein kinase promoter hypermethylation in normal human lymphocytes. Cancer Res. 2003 Nov 15; 63(22):7694-8. PMID: 14633692.
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    231. Minhas KM, Singh B, Jiang WW, Sidransky D, Califano J. Spindle assembly checkpoint defects and chromosomal instability in head and neck squamous cell carcinoma. Int J Cancer. 2003 Oct 20; 107(1):46-52. PMID: 12925955.
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    232. Ha PK, Benoit NE, Yochem R, Sciubba J, Zahurak M, Sidransky D, Pevsner J, Westra WH, Califano J. A transcriptional progression model for head and neck cancer. Clin Cancer Res. 2003 Aug 01; 9(8):3058-64. PMID: 12912957.
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    233. Wu G, Nomoto S, Hoque MO, Dracheva T, Osada M, Lee CC, Dong SM, Guo Z, Benoit N, Cohen Y, Rechthand P, Califano J, Moon CS, Ratovitski E, Jen J, Sidransky D, Trink B. DeltaNp63alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and development. Cancer Res. 2003 May 15; 63(10):2351-7. PMID: 12750249.
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    234. Xing M, Usadel H, Cohen Y, Tokumaru Y, Guo Z, Westra WB, Tong BC, Tallini G, Udelsman R, Califano J, Ladenson PW, Sidransky D. Methylation of the thyroid-stimulating hormone receptor gene in epithelial thyroid tumors: a marker of malignancy and a cause of gene silencing. Cancer Res. 2003 May 01; 63(9):2316-21. PMID: 12727856.
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    235. Tong BC, Ha PK, Dhir K, Xing M, Westra WH, Sidransky D, Califano J. Mitochondrial DNA alterations in thyroid cancer. J Surg Oncol. 2003 Mar; 82(3):170-3. PMID: 12619060.
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    236. Foster SE, Vaughan RD, Foster WH, Califano J. Alcohol consumption and expenditures for underage drinking and adult excessive drinking. JAMA. 2003 Feb 26; 289(8):989-95. PMID: 12597750.
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    237. Califano J, Cordeiro PG, Disa JJ, Hidalgo DA, DuMornay W, Bilsky MH, Gutin PH, Shah JP, Kraus DH. Anterior cranial base reconstruction using free tissue transfer: changing trends. Head Neck. 2003 Feb; 25(2):89-96. PMID: 12509790.
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    238. Ha PK, Califano J. The molecular biology of mucosal field cancerization of the head and neck. Crit Rev Oral Biol Med. 2003; 14(5):363-9. PMID: 14530304.
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    239. Earnest L, Byrne P, Califano J. Massive facial angiofibroma in a patient with tuberous sclerosis. Otolaryngol Head Neck Surg. 2003 Jan; 128(1):151-3. PMID: 12574776.
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    240. Ha PK, Pilkington TA, Westra WH, Sciubba J, Sidransky D, Califano J. Progression of microsatellite instability from premalignant lesions to tumors of the head and neck. Int J Cancer. 2002 Dec 20; 102(6):615-7. PMID: 12448003.
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    241. Ha PK, Califano J. The molecular biology of laryngeal cancer. Otolaryngol Clin North Am. 2002 Oct; 35(5):993-1012. PMID: 12587244.
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    242. Goldstein B, Westra WH, Califano J. Multifocal papillary thyroid carcinoma arising in a lingual thyroid: a case report. Arch Otolaryngol Head Neck Surg. 2002 Oct; 128(10):1198-200. PMID: 12365894.
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    243. Ansari-Lari MA, Hoque MO, Califano J, Westra WH. Immunohistochemical p53 expression patterns in sarcomatoid carcinomas of the upper respiratory tract. Am J Surg Pathol. 2002 Aug; 26(8):1024-31. PMID: 12170089.
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    244. Ha PK, Tong BC, Westra WH, Sanchez-Cespedes M, Parrella P, Zahurak M, Sidransky D, Califano J. Mitochondrial C-tract alteration in premalignant lesions of the head and neck: a marker for progression and clonal proliferation. Clin Cancer Res. 2002 Jul; 8(7):2260-5. PMID: 12114429.
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    245. Patturajan M, Nomoto S, Sommer M, Fomenkov A, Hibi K, Zangen R, Poliak N, Califano J, Trink B, Ratovitski E, Sidransky D. DeltaNp63 induces beta-catenin nuclear accumulation and signaling. Cancer Cell. 2002 May; 1(4):369-79. PMID: 12086851.
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    246. Ha PK, Pai SI, Westra WH, Gillison ML, Tong BC, Sidransky D, Califano J. Real-time quantitative PCR demonstrates low prevalence of human papillomavirus type 16 in premalignant and malignant lesions of the oral cavity. Clin Cancer Res. 2002 May; 8(5):1203-9. PMID: 12006539.
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    247. Califano J. Physician-assisted living. America (NY). 1998 Nov 14; 179(15):10-2. PMID: 11660567.
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    248. Califano J. The dangers of discovery. America (NY). 1995 Jan 14; 172(1):8-11. PMID: 11660146.
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    249. Califano J. Rationing health care: the unnecessary solution. Univ PA Law Rev. 1992 May; 140(5):1525-38. PMID: 11651590.
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    250. Califano J. Moral leadership and partisanship. America (NY). 1984 Sep 29; 151(8):164-5. PMID: 11658534.
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    251. Califano J. The infighting over abortion: an administration divided. Washington Post. 1981 May 19; A1, A6. PMID: 11647323.
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    252. Califano J. Califano and abortion: questions of conscience. Washington Post. 1981 May 18; A1, A12. PMID: 11647322.
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    253. Califano J. Sterilization. Forum (Wash). 1978; 2(2):7-13. PMID: 11643514.
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