David Schlaepfer

Title(s)Professor, Ob/Gyn & Reproductive sciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0003-4814-9210 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Princeton, New JerseyAB06/1985Biology
    UC Irvine, IrvinePhD08/1992Biological Sciences
    The Salk Institute for Biological Studies, La Jollapostdoc06/1996Molecular Biology and Virology
    Collapse Awards and Honors
    American Heart Association2005  - 2010Established Investigator Award
    American Cancer Society1994Postdoctoral Fellowship
    National Research Service Award (NRSA) Individual Fellowship1992Postdoctoral Fellowship
    University of California Regents’ Fellowship1987Graduate Fellowship

    Collapse Overview 
    Collapse Overview
    David Schlaepfer was born and raised in southern California, active in sports, and served as high school student body president. He graduated cum laude from Princeton University with an A.B. in biology (1985). As a graduate student in biological chemistry mentored by Dr. Harry Haigler PhD at UC Irvine, David was the first to purify, clone, and characterize annexin V. As a postdoctoral researcher with Dr. Tony Hunter PhD at The Salk Institute for Biological Studies, David showed that integrin receptor binding to fibronectin was linked to Ras-MAP kinase by Grb2 binding to tyrosine phosphorylated focal adhesion kinase (FAK). In 1996, David joined the Department of Immunology at the Scripps Research Institute as an Assistant Professor where his group led the field in the molecular analyses of FAK protein function in promoting cell movement, invasion, and tumor cell survival. In 2005, David was awarded an American Heart Association Established Investigator Award for his pioneering work demonstrating differential roles for FAK expression or activity in developmental blood vessel morphogenesis using conditional knockout and knockin transgenic mouse models.

    In 2007, David joined the UC San Diego Health Moores Cancer Center, Division of Gynecologic Oncology as a Professor in the Department of Obstetrics, Gynecology, and Reproductive Sciences. The FAK gene (PTK2) is localized to a genetic locus (8q24) linked to ovarian cancer and elevated FAK expression occurs as a function of tumor progression. Using multiple cutting edge research tools and newly-derived ovarian syngeneic mouse tumor models, Schlaepfer lab studies have provided insights into tumor chemotherapy resistance and new checkpoint immunotherapy combinations with small molecule FAK inhibitors that are being tested in human clinical trials. David has trained more than thirty graduate students, postdoctoral, or MD fellows who have achieved productive careers in academia or in the bio-pharmaceutical industry. He has been continuously funded by the NIH since 1996 and strives to make translational gynecologic oncology research advances.

    Collapse Research 
    Collapse Research Activities and Funding
    Reprogramming the Tumor Microenvironment in Ovarian Cancer
    NIH R01CA254342Jul 3, 2020 - Jun 30, 2025
    Role: Principal Investigator
    Dissecting FAK-regulated oncogenic signaling programs in ovarian cancer
    NIH R01CA247562May 1, 2020 - Apr 30, 2025
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. FAK, vinculin, and talin control mechanosensitive YAP nuclear localization. Biomaterials. 2024 Mar 20; 308:122542. Holland EN, Fernández-Yagüe MA, Zhou DW, O'Neill EB, Woodfolk AU, Mora-Boza A, Fu J, Schlaepfer DD, García AJ. PMID: 38547833.
      View in: PubMed   Mentions:    Fields:    
    2. Author Correction: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med. 2024 Mar; 30(3):908. Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM. PMID: 38017076.
      View in: PubMed   Mentions:    Fields:    
    3. TGFBI remodels adipose metabolism by regulating the Notch-1 signaling pathway. Exp Mol Med. 2023 03; 55(3):520-531. Lee SG, Chae J, Woo SM, Seo SU, Kim HJ, Kim SY, Schlaepfer DD, Kim IS, Park HS, Kwon TK, Nam JO. PMID: 36854775; PMCID: PMC10073093.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    4. Tumor FAK orchestrates immunosuppression in ovarian cancer via the CD155/TIGIT axis. Proc Natl Acad Sci U S A. 2022 04 26; 119(17):e2117065119. Ozmadenci D, Shankara Narayanan JS, Andrew J, Ojalill M, Barrie AM, Jiang S, Iyer S, Chen XL, Rose M, Estrada V, Molinolo A, Bertotto T, Mikulski Z, McHale MC, White RR, Connolly DC, Pachter JA, Kuchroo VK, Stupack DG, Schlaepfer DD. PMID: 35467979; PMCID: PMC9169934.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    5. FAK Activation Promotes SMC Dedifferentiation via Increased DNA Methylation in Contractile Genes. Circ Res. 2021 12 03; 129(12):e215-e233. Jeong K, Murphy JM, Kim JH, Campbell PM, Park H, Rodriguez YAR, Choi CS, Kim JS, Park S, Kim HJ, Scammell JG, Weber DS, Honkanen RE, Schlaepfer DD, Ahn EE, Lim SS. PMID: 34702049; PMCID: PMC8639767.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    6. Endothelial angiogenic activity and adipose angiogenesis is controlled by extracellular matrix protein TGFBI. Sci Rep. 2021 05 06; 11(1):9644. Lee SG, Kim JS, Kim HJ, Schlaepfer DD, Kim IS, Nam JO. PMID: 33958649; PMCID: PMC8102489.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    7. Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair. Nat Commun. 2021 04 21; 12(1):2359. Zhou DW, Fernández-Yagüe MA, Holland EN, García AF, Castro NS, O'Neill EB, Eyckmans J, Chen CS, Fu J, Schlaepfer DD, García AJ. PMID: 33883558; PMCID: PMC8060400.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    8. Targeting FAK in anticancer combination therapies. Nat Rev Cancer. 2021 05; 21(5):313-324. Dawson JC, Serrels A, Stupack DG, Schlaepfer DD, Frame MC. PMID: 33731845; PMCID: PMC8276817.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimals
    9. FAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer. EMBO Mol Med. 2020 11 06; 12(11):e12010. Zaghdoudi S, Decaup E, Belhabib I, Samain R, Cassant-Sourdy S, Rochotte J, Brunel A, Schlaepfer D, Cros J, Neuzillet C, Strehaiano M, Alard A, Tomasini R, Rajeeve V, Perraud A, Mathonnet M, Pearce OM, Martineau Y, Pyronnet S, Bousquet C, Jean C. PMID: 33025708; PMCID: PMC7645544.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    10. Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors. PLoS Genet. 2020 01; 16(1):e1008558. Delaney JR, Patel CB, Bapat J, Jones CM, Ramos-Zapatero M, Ortell KK, Tanios R, Haghighiabyaneh M, Axelrod J, DeStefano JW, Tancioni I, Schlaepfer DD, Harismendy O, La Spada AR, Stupack DG. PMID: 31923184; PMCID: PMC6953790.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    11. FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy. Elife. 2019 09 03; 8. Diaz Osterman CJ, Ozmadenci D, Kleinschmidt EG, Taylor KN, Barrie AM, Jiang S, Bean LM, Sulzmaier FJ, Jean C, Tancioni I, Anderson K, Uryu S, Cordasco EA, Li J, Chen XL, Fu G, Ojalill M, Rappu P, Heino J, Mark AM, Xu G, Fisch KM, Kolev VN, Weaver DT, Pachter JA, Gyorffy B, McHale MT, Connolly DC, Molinolo A, Stupack DG, Schlaepfer DD. PMID: 31478830; PMCID: PMC6721800.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    12. Rgnef promotes ovarian tumor progression and confers protection from oxidative stress. Oncogene. 2019 09; 38(36):6323-6337. Kleinschmidt EG, Miller NLG, Ozmadenci D, Tancioni I, Osterman CD, Barrie AM, Taylor KN, Ye A, Jiang S, Connolly DC, Stupack DG, Schlaepfer DD. PMID: 31308489; PMCID: PMC7252434.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    13. Nuclear Focal Adhesion Kinase Controls Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia Through GATA4-Mediated Cyclin D1 Transcription. Circ Res. 2019 07 05; 125(2):152-166. Jeong K, Kim JH, Murphy JM, Park H, Kim SJ, Rodriguez YAR, Kong H, Choi C, Guan JL, Taylor JM, Lincoln TM, Gerthoffer WT, Kim JS, Ahn EE, Schlaepfer DD, Lim SS. PMID: 31096851; PMCID: PMC6702425.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    14. A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK. Cancer Cell. 2019 03 18; 35(3):457-472.e5. Feng X, Arang N, Rigiracciolo DC, Lee JS, Yeerna H, Wang Z, Lubrano S, Kishore A, Pachter JA, König GM, Maggiolini M, Kostenis E, Schlaepfer DD, Tamayo P, Chen Q, Ruppin E, Gutkind JS. PMID: 30773340; PMCID: PMC6737937.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    15. Adaptive Resistance to Chemotherapy, A Multi-FAK-torial Linkage. Mol Cancer Ther. 2018 04; 17(4):719-723. Taylor KN, Schlaepfer DD. PMID: 29610281; PMCID: PMC6538033.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    16. Focal adhesion kinase signaling in unexpected places. Curr Opin Cell Biol. 2017 04; 45:24-30. Kleinschmidt EG, Schlaepfer DD. PMID: 28213315; PMCID: PMC5482783.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    17. Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer. Nat Commun. 2017 02 15; 8:14423. Delaney JR, Patel CB, Willis KM, Haghighiabyaneh M, Axelrod J, Tancioni I, Lu D, Bapat J, Young S, Cadassou O, Bartakova A, Sheth P, Haft C, Hui S, Saenz C, Schlaepfer DD, Harismendy O, Stupack DG. PMID: 28198375; PMCID: PMC5316854.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    18. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med. 2016 05; 22(5):497-505. Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM. PMID: 27089513; PMCID: PMC4860133.
      View in: PubMed   Mentions: 285     Fields:    Translation:HumansAnimalsCells
    19. Oxidized LDL induces FAK-dependent RSK signaling to drive NF-κB activation and VCAM-1 expression. J Cell Sci. 2016 Apr 15; 129(8):1580-91. Yurdagul A, Sulzmaier FJ, Chen XL, Pattillo CB, Schlaepfer DD, Orr AW. PMID: 26906414; PMCID: PMC4852771.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    20. A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer. Oncotarget. 2015 Oct 13; 6(31):31104-18. Delaney JR, Patel C, McCabe KE, Lu D, Davis MA, Tancioni I, von Schalscha T, Bartakova A, Haft C, Schlaepfer DD, Stupack DG. PMID: 26418751; PMCID: PMC4741591.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    21. FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β. Elife. 2015 Sep 03; 4. Gao C, Chen G, Kuan SF, Zhang DH, Schlaepfer DD, Hu J. PMID: 26274564; PMCID: PMC4558782.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    22. Integrin α4 Enhances Metastasis and May Be Associated with Poor Prognosis in MYCN-low Neuroblastoma. PLoS One. 2015; 10(5):e0120815. Young SA, McCabe KE, Bartakova A, Delaney J, Pizzo DP, Newbury RO, Varner JA, Schlaepfer DD, Stupack DG. PMID: 25973900; PMCID: PMC4431816.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    23. Gastrin-stimulated Gα13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells. J Biol Chem. 2015 Jun 12; 290(24):15197-209. Masià-Balagué M, Izquierdo I, Garrido G, Cordomí A, Pérez-Benito L, Miller NL, Schlaepfer DD, Gigoux V, Aragay AM. PMID: 25922072; PMCID: PMC4463461.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    24. FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth. Breast Cancer Res. 2015 Mar 28; 17:47. Tancioni I, Miller NL, Uryu S, Lawson C, Jean C, Chen XL, Kleinschmidt EG, Schlaepfer DD. PMID: 25880415; PMCID: PMC4407832.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    25. FAK in cancer: mechanistic findings and clinical applications. Nat Rev Cancer. 2014 Sep; 14(9):598-610. Sulzmaier FJ, Jean C, Schlaepfer DD. PMID: 25098269; PMCID: PMC4365862.
      View in: PubMed   Mentions: 628     Fields:    Translation:HumansAnimalsCells
    26. FAK Inhibition disrupts a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth. Mol Cancer Ther. 2014 Aug; 13(8):2050-61. Tancioni I, Uryu S, Sulzmaier FJ, Shah NR, Lawson C, Miller NL, Jean C, Chen XL, Ward KK, Schlaepfer DD. PMID: 24899686; PMCID: PMC4126870.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    27. Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer. Gynecol Oncol. 2014 Jul; 134(1):104-11. Shah NR, Tancioni I, Ward KK, Lawson C, Chen XL, Jean C, Sulzmaier FJ, Uryu S, Miller NL, Connolly DC, Schlaepfer DD. PMID: 24786638; PMCID: PMC4065804.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    28. RhoGEFs in cell motility: novel links between Rgnef and focal adhesion kinase. Curr Mol Med. 2014 Feb; 14(2):221-34. Miller NL, Kleinschmidt EG, Schlaepfer DD. PMID: 24467206; PMCID: PMC4075329.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    29. Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function. J Cell Biol. 2014 Jan 20; 204(2):247-63. Jean C, Chen XL, Nam JO, Tancioni I, Uryu S, Lawson C, Ward KK, Walsh CT, Miller NL, Ghassemian M, Turowski P, Dejana E, Weis S, Cheresh DA, Schlaepfer DD. PMID: 24446483; PMCID: PMC3897185.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    30. Grb2 promotes integrin-induced focal adhesion kinase (FAK) autophosphorylation and directs the phosphorylation of protein tyrosine phosphatase α by the Src-FAK kinase complex. Mol Cell Biol. 2014 Feb; 34(3):348-61. Cheng SY, Sun G, Schlaepfer DD, Pallen CJ. PMID: 24248601; PMCID: PMC3911518.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    31. pHocal adhesion kinase regulation is on a FERM foundation. J Cell Biol. 2013 Sep 16; 202(6):833-6. Lawson C, Schlaepfer DD. PMID: 24043698; PMCID: PMC3776349.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    32. A non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation. J Cell Sci. 2013 Nov 01; 126(Pt 21):5074-85. Miller NL, Lawson C, Kleinschmidt EG, Tancioni I, Uryu S, Schlaepfer DD. PMID: 24006257; PMCID: PMC3820247.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    33. Src-inducible association of CrkL with procaspase-8 promotes cell migration. Cell Adh Migr. 2013 Jul-Aug; 7(4):362-9. Graf R, Barbero S, Keller N, Chen L, Uryu S, Schlaepfer D, Stupack D. PMID: 23751956; PMCID: PMC3739813.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    34. Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression. Clin Exp Metastasis. 2013 Jun; 30(5):579-94. Ward KK, Tancioni I, Lawson C, Miller NL, Jean C, Chen XL, Uryu S, Kim J, Tarin D, Stupack DG, Plaxe SC, Schlaepfer DD. PMID: 23275034; PMCID: PMC3622195.
      View in: PubMed   Mentions: 65     Fields:    Translation:Humans
    35. Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells. J Cell Sci. 2012 Dec 15; 125(Pt 24):5960-73. Jung O, Choi S, Jang SB, Lee SA, Lim ST, Choi YJ, Kim HJ, Kim DH, Kwak TK, Kim H, Kang M, Lee MS, Park SY, Ryu J, Jeong D, Cheong HK, Kim HJ, Park KH, Lee BJ, Schlaepfer DD, Lee JW. PMID: 23077174; PMCID: PMC4074290.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    36. Cortactin as a target for FAK in the regulation of focal adhesion dynamics. PLoS One. 2012; 7(8):e44041. Tomar A, Lawson C, Ghassemian M, Schlaepfer DD. PMID: 22952866; PMCID: PMC3430618.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    37. Integrin adhesions: who's on first? What's on second? Connections between FAK and talin. Cell Adh Migr. 2012 Jul-Aug; 6(4):302-6. Lawson C, Schlaepfer DD. PMID: 22983197; PMCID: PMC3478250.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    38. Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression. J Cell Biol. 2012 Jun 25; 197(7):907-19. Lim ST, Miller NL, Chen XL, Tancioni I, Walsh CT, Lawson C, Uryu S, Weis SM, Cheresh DA, Schlaepfer DD. PMID: 22734001; PMCID: PMC3384409.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    39. Rgnef (p190RhoGEF) knockout inhibits RhoA activity, focal adhesion establishment, and cell motility downstream of integrins. PLoS One. 2012; 7(5):e37830. Miller NL, Lawson C, Chen XL, Lim ST, Schlaepfer DD. PMID: 22649559; PMCID: PMC3359313.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    40. EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1. PLoS One. 2012; 7(5):e36753. Lau SK, Shields DJ, Murphy EA, Desgrosellier JS, Anand S, Huang M, Kato S, Lim ST, Weis SM, Stupack DG, Schlaepfer DD, Cheresh DA. PMID: 22586492; PMCID: PMC3346745.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    41. FAK promotes recruitment of talin to nascent adhesions to control cell motility. J Cell Biol. 2012 Jan 23; 196(2):223-32. Lawson C, Lim ST, Uryu S, Chen XL, Calderwood DA, Schlaepfer DD. PMID: 22270917; PMCID: PMC3265949.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    42. VEGF-induced vascular permeability is mediated by FAK. Dev Cell. 2012 Jan 17; 22(1):146-57. Chen XL, Nam JO, Jean C, Lawson C, Walsh CT, Goka E, Lim ST, Tomar A, Tancioni I, Uryu S, Guan JL, Acevedo LM, Weis SM, Cheresh DA, Schlaepfer DD. PMID: 22264731; PMCID: PMC3266538.
      View in: PubMed   Mentions: 179     Fields:    Translation:AnimalsCells
    43. Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells. J Cell Biol. 2011 Nov 28; 195(5):729-38. Li XY, Zhou X, Rowe RG, Hu Y, Schlaepfer DD, Ilic D, Dressler G, Park A, Guan JL, Weiss SJ. PMID: 22105351; PMCID: PMC3257570.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    44. EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation. Oncogene. 2012 May 31; 31(22):2783-93. Huang M, Anand S, Murphy EA, Desgrosellier JS, Stupack DG, Shattil SJ, Schlaepfer DD, Cheresh DA. PMID: 21963850; PMCID: PMC3711644.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    45. Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer. Nat Commun. 2011 Jul 26; 2:406. Seong J, Ouyang M, Kim T, Sun J, Wen PC, Lu S, Zhuo Y, Llewellyn NM, Schlaepfer DD, Guan JL, Chien S, Wang Y. PMID: 21792185; PMCID: PMC3373894.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    46. p190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinase. Cancer Res. 2011 Jan 15; 71(2):360-70. Yu HG, Nam JO, Miller NL, Tanjoni I, Walsh C, Shi L, Kim L, Chen XL, Tomar A, Lim ST, Schlaepfer DD. PMID: 21224360; PMCID: PMC3064514.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    47. PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol Ther. 2010 May 15; 9(10):764-77. Tanjoni I, Walsh C, Uryu S, Tomar A, Nam JO, Mielgo A, Lim ST, Liang C, Koenig M, Sun C, Patel N, Kwok C, McMahon G, Stupack DG, Schlaepfer DD. PMID: 20234191; PMCID: PMC2933317.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    48. Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models. Cancer Biol Ther. 2010 May 15; 9(10):778-90. Walsh C, Tanjoni I, Uryu S, Tomar A, Nam JO, Luo H, Phillips A, Patel N, Kwok C, McMahon G, Stupack DG, Schlaepfer DD. PMID: 20234193; PMCID: PMC2933309.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    49. Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation. J Biol Chem. 2010 Jul 09; 285(28):21526-36. Lim ST, Chen XL, Tomar A, Miller NL, Yoo J, Schlaepfer DD. PMID: 20442405; PMCID: PMC2898428.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    50. Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation. J Cell Biol. 2010 Mar 22; 188(6):877-90. Pasapera AM, Schneider IC, Rericha E, Schlaepfer DD, Waterman CM. PMID: 20308429; PMCID: PMC2845065.
      View in: PubMed   Mentions: 291     Fields:    Translation:AnimalsCells
    51. A PAK-activated linker for EGFR and FAK. Dev Cell. 2010 Feb 16; 18(2):170-2. Tomar A, Schlaepfer DD. PMID: 20159588; PMCID: PMC3081666.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    52. Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival. J Biol Chem. 2010 Jan 15; 285(3):1743-53. Lim ST, Miller NL, Nam JO, Chen XL, Lim Y, Schlaepfer DD. PMID: 19880522; PMCID: PMC2804332.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    53. Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility. Curr Opin Cell Biol. 2009 Oct; 21(5):676-83. Tomar A, Schlaepfer DD. PMID: 19525103; PMCID: PMC2754589.
      View in: PubMed   Mentions: 120     Fields:    Translation:AnimalsCells
    54. A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells. J Cell Sci. 2009 Jun 01; 122(Pt 11):1852-62. Tomar A, Lim ST, Lim Y, Schlaepfer DD. PMID: 19435801; PMCID: PMC2684836.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    55. Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis. Cancer Res. 2009 May 01; 69(9):3755-63. Barbero S, Mielgo A, Torres V, Teitz T, Shields DJ, Mikolon D, Bogyo M, Barilà D, Lahti JM, Schlaepfer D, Stupack DG. PMID: 19383910; PMCID: PMC2684981.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    56. Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motility. PLoS Pathog. 2009 Feb; 5(2):e1000304. Vomaske J, Melnychuk RM, Smith PP, Powell J, Hall L, DeFilippis V, Früh K, Smit M, Schlaepfer DD, Nelson JA, Streblow DN. PMID: 19229316; PMCID: PMC2637432.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    57. Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis. Cancer Res. 2009 Feb 15; 69(4):1383-91. Ricono JM, Huang M, Barnes LA, Lau SK, Weis SM, Schlaepfer DD, Hanks SK, Cheresh DA. PMID: 19208836; PMCID: PMC2741736.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    58. Establishment of cell lines from mouse embryos with early embryonic lethality. Cell Commun Adhes. 2008 Nov; 15(4):379-83. Howerton K, Schlaepfer DD, Ilic D. PMID: 18979299; PMCID: PMC3057554.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    59. FAK nuclear export signal sequences. FEBS Lett. 2008 Jul 09; 582(16):2402-6. Ossovskaya V, Lim ST, Ota N, Schlaepfer DD, Ilic D. PMID: 18549812; PMCID: PMC2547126.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    60. FERM control of FAK function: implications for cancer therapy. Cell Cycle. 2008 Aug; 7(15):2306-14. Lim ST, Mikolon D, Stupack DG, Schlaepfer DD. PMID: 18677107; PMCID: PMC2574722.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    61. Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK. J Cell Biol. 2008 Apr 07; 181(1):43-50. Weis SM, Lim ST, Lutu-Fuga KM, Barnes LA, Chen XL, Göthert JR, Shen TL, Guan JL, Schlaepfer DD, Cheresh DA. PMID: 18391070; PMCID: PMC2287283.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    62. Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol Cell. 2008 Jan 18; 29(1):9-22. Lim ST, Chen XL, Lim Y, Hanson DA, Vo TT, Howerton K, Larocque N, Fisher SJ, Schlaepfer DD, Ilic D. PMID: 18206965; PMCID: PMC2234035.
      View in: PubMed   Mentions: 261     Fields:    Translation:AnimalsCells
    63. PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility. J Cell Biol. 2008 Jan 14; 180(1):187-203. Lim Y, Lim ST, Tomar A, Gardel M, Bernard-Trifilo JA, Chen XL, Uryu SA, Canete-Soler R, Zhai J, Lin H, Schlaepfer WW, Nalbant P, Bokoch G, Ilic D, Waterman-Storer C, Schlaepfer DD. PMID: 18195107; PMCID: PMC2213606.
      View in: PubMed   Mentions: 129     Fields:    Translation:AnimalsCells
    64. Distinct FAK-Src activation events promote alpha5beta1 and alpha4beta1 integrin-stimulated neuroblastoma cell motility. Oncogene. 2008 Feb 28; 27(10):1439-48. Wu L, Bernard-Trifilo JA, Lim Y, Lim ST, Mitra SK, Uryu S, Chen M, Pallen CJ, Cheung NK, Mikolon D, Mielgo A, Stupack DG, Schlaepfer DD. PMID: 17828307; PMCID: PMC2593630.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    65. Focal adhesion kinase controls pH-dependent epidermal barrier homeostasis by regulating actin-directed Na+/H+ exchanger 1 plasma membrane localization. Am J Pathol. 2007 Jun; 170(6):2055-67. Ilic D, Mao-Qiang M, Crumrine D, Dolganov G, Larocque N, Xu P, Demerjian M, Brown BE, Lim ST, Ossovskaya V, Schlaepfer DD, Fisher SJ, Feingold KR, Elias PM, Mauro TM. PMID: 17525272; PMCID: PMC1899430.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    66. Tumor necrosis factor-alpha stimulates focal adhesion kinase activity required for mitogen-activated kinase-associated interleukin 6 expression. J Biol Chem. 2007 Jun 15; 282(24):17450-9. Schlaepfer DD, Hou S, Lim ST, Tomar A, Yu H, Lim Y, Hanson DA, Uryu SA, Molina J, Mitra SK. PMID: 17438336.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    67. Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol. 2006 Oct; 18(5):516-23. Mitra SK, Schlaepfer DD. PMID: 16919435.
      View in: PubMed   Mentions: 770     Fields:    Translation:AnimalsCells
    68. Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumors. Oncogene. 2006 Sep 28; 25(44):5969-84. Mitra SK, Mikolon D, Molina JE, Hsia DA, Hanson DA, Chi A, Lim ST, Bernard-Trifilo JA, Ilic D, Stupack DG, Cheresh DA, Schlaepfer DD. PMID: 16682956.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    69. Analyzing FAK and Pyk2 in early integrin signaling events. Curr Protoc Cell Biol. 2006 Apr; Chapter 14:Unit 14.7. Bernard-Trifilo JA, Lim ST, Hou S, Schlaepfer DD, Ilic D. PMID: 18228476.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    70. Intrinsic focal adhesion kinase activity controls orthotopic breast carcinoma metastasis via the regulation of urokinase plasminogen activator expression in a syngeneic tumor model. Oncogene. 2006 Jul 27; 25(32):4429-40. Mitra SK, Lim ST, Chi A, Schlaepfer DD. PMID: 16547501.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    71. Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signaling pathway. Cancer Res. 2006 Jan 15; 66(2):775-83. Hu B, Jarzynka MJ, Guo P, Imanishi Y, Schlaepfer DD, Cheng SY. PMID: 16424009; PMCID: PMC2868063.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    72. FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion. J Cell Biol. 2005 Nov 07; 171(3):505-16. Benlimame N, He Q, Jie S, Xiao D, Xu YJ, Loignon M, Schlaepfer DD, Alaoui-Jamali MA. PMID: 16275754; PMCID: PMC2171271.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    73. Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src. Mol Cell Biol. 2005 Nov; 25(21):9700-12. Hsia DA, Lim ST, Bernard-Trifilo JA, Mitra SK, Tanaka S, den Hertog J, Streblow DN, Ilic D, Ginsberg MH, Schlaepfer DD. PMID: 16227616; PMCID: PMC1265817.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    74. alpha(v)beta3-integrin-dependent activation of focal adhesion kinase mediates NF-kappaB activation and motogenic activity by HIV-1 Tat in endothelial cells. J Cell Sci. 2005 Sep 01; 118(Pt 17):3949-58. Urbinati C, Bugatti A, Giacca M, Schlaepfer D, Presta M, Rusnati M. PMID: 16105876.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    75. Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol. 2005 Jan; 6(1):56-68. Mitra SK, Hanson DA, Schlaepfer DD. PMID: 15688067.
      View in: PubMed   Mentions: 1127     Fields:    Translation:HumansAnimalsCells
    76. Control of motile and invasive cell phenotypes by focal adhesion kinase. Biochim Biophys Acta. 2004 Jul 05; 1692(2-3):77-102. Schlaepfer DD, Mitra SK, Ilic D. PMID: 15246681.
      View in: PubMed   Mentions: 192     Fields:    Translation:HumansAnimalsCells
    77. The cytoplasmic tyrosine kinase Pyk2 as a novel effector of fibroblast growth factor receptor 3 activation. J Biol Chem. 2004 Jul 02; 279(27):28450-7. Meyer AN, Gastwirt RF, Schlaepfer DD, Donoghue DJ. PMID: 15105428.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    78. Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling. Science. 2004 Feb 06; 303(5659):836-9. Palazzo AF, Eng CH, Schlaepfer DD, Marcantonio EE, Gundersen GG. PMID: 14764879.
      View in: PubMed   Mentions: 181     Fields:    Translation:AnimalsCells
    79. Multiple connections link FAK to cell motility and invasion. Curr Opin Genet Dev. 2004 Feb; 14(1):92-101. Schlaepfer DD, Mitra SK. PMID: 15108811.
      View in: PubMed   Mentions: 175     Fields:    Translation:Cells
    80. FAK promotes organization of fibronectin matrix and fibrillar adhesions. J Cell Sci. 2004 Jan 15; 117(Pt 2):177-87. Ilic D, Kovacic B, Johkura K, Schlaepfer DD, Tomasevic N, Han Q, Kim JB, Howerton K, Baumbusch C, Ogiwara N, Streblow DN, Nelson JA, Dazin P, Shino Y, Sasaki K, Damsky CH. PMID: 14657279.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    81. Human cytomegalovirus chemokine receptor US28-induced smooth muscle cell migration is mediated by focal adhesion kinase and Src. J Biol Chem. 2003 Dec 12; 278(50):50456-65. Streblow DN, Vomaske J, Smith P, Melnychuk R, Hall L, Pancheva D, Smit M, Casarosa P, Schlaepfer DD, Nelson JA. PMID: 14506272.
      View in: PubMed   Mentions: 48     Fields:    Translation:Cells
    82. Paxillin binding to the alpha 4 integrin subunit stimulates LFA-1 (integrin alpha L beta 2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2. J Immunol. 2003 Jun 15; 170(12):5912-8. Rose DM, Liu S, Woodside DG, Han J, Schlaepfer DD, Ginsberg MH. PMID: 12794117.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    83. Direct interaction of focal adhesion kinase with p190RhoGEF. J Biol Chem. 2003 Jul 04; 278(27):24865-73. Zhai J, Lin H, Nie Z, Wu J, Cañete-Soler R, Schlaepfer WW, Schlaepfer DD. PMID: 12702722.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    84. Differential regulation of cell motility and invasion by FAK. J Cell Biol. 2003 Mar 03; 160(5):753-67. Hsia DA, Mitra SK, Hauck CR, Streblow DN, Nelson JA, Ilic D, Huang S, Li E, Nemerow GR, Leng J, Spencer KS, Cheresh DA, Schlaepfer DD. PMID: 12615911; PMCID: PMC2173366.
      View in: PubMed   Mentions: 206     Fields:    Translation:AnimalsCells
    85. Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. J Cell Biol. 2002 Apr 01; 157(1):149-60. Eliceiri BP, Puente XS, Hood JD, Stupack DG, Schlaepfer DD, Huang XZ, Sheppard D, Cheresh DA. PMID: 11927607; PMCID: PMC2173263.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansAnimalsCells
    86. The cytoskeletal/non-muscle isoform of alpha-actinin is phosphorylated on its actin-binding domain by the focal adhesion kinase. J Biol Chem. 2001 Aug 03; 276(31):28676-85. Izaguirre G, Aguirre L, Hu YP, Lee HY, Schlaepfer DD, Aneskievich BJ, Haimovich B. PMID: 11369769.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    87. The v-Src SH3 domain facilitates a cell adhesion-independent association with focal adhesion kinase. J Biol Chem. 2001 May 25; 276(21):17653-62. Hauck CR, Hunter T, Schlaepfer DD. PMID: 11278488.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    88. Targeting Pyk2 to beta 1-integrin-containing focal contacts rescues fibronectin-stimulated signaling and haptotactic motility defects of focal adhesion kinase-null cells. J Cell Biol. 2001 Jan 08; 152(1):97-110. Klingbeil CK, Hauck CR, Hsia DA, Jones KC, Reider SR, Schlaepfer DD. PMID: 11149924; PMCID: PMC2193658.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    89. Focal adhesion kinase facilitates platelet-derived growth factor-BB-stimulated ERK2 activation required for chemotaxis migration of vascular smooth muscle cells. J Biol Chem. 2000 Dec 29; 275(52):41092-9. Hauck CR, Hsia DA, Schlaepfer DD. PMID: 10998418.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    90. Cell adhesion and focal adhesion kinase regulate insulin receptor substrate-1 expression. J Biol Chem. 2000 Dec 08; 275(49):38371-7. Lebrun P, Baron V, Hauck CR, Schlaepfer DD, Van Obberghen E. PMID: 10967115.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    91. Involvement of focal adhesion kinase in Escherichia coli invasion of human brain microvascular endothelial cells. Infect Immun. 2000 Nov; 68(11):6423-30. Reddy MA, Wass CA, Kim KS, Schlaepfer DD, Prasadarao NV. PMID: 11035755; PMCID: PMC97729.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    92. Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover. J Cell Sci. 2000 Oct; 113 ( Pt 20):3673-8. Ren XD, Kiosses WB, Sieg DJ, Otey CA, Schlaepfer DD, Schwartz MA. PMID: 11017882.
      View in: PubMed   Mentions: 163     Fields:    Translation:AnimalsCells
    93. Association of p130CAS with phosphatidylinositol-3-OH kinase mediates adenovirus cell entry. J Biol Chem. 2000 May 12; 275(19):14729-35. Li E, Stupack DG, Brown SL, Klemke R, Schlaepfer DD, Nemerow GR. PMID: 10799562.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    94. FAK integrates growth-factor and integrin signals to promote cell migration. Nat Cell Biol. 2000 May; 2(5):249-56. Sieg DJ, Hauck CR, Ilic D, Klingbeil CK, Schaefer E, Damsky CH, Schlaepfer DD. PMID: 10806474.
      View in: PubMed   Mentions: 451     Fields:    Translation:HumansCells
    95. Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase. J Cell Biol. 2000 May 01; 149(3):741-54. Almeida EA, Ilic D, Han Q, Hauck CR, Jin F, Kawakatsu H, Schlaepfer DD, Damsky CH. PMID: 10791986; PMCID: PMC2174844.
      View in: PubMed   Mentions: 108     Fields:    Translation:AnimalsCells
    96. Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration. Immunol Res. 2000; 21(2-3):293-303. Hauck CR, Klingbeil CK, Schlaepfer DD. PMID: 10852130.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    97. Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration. J Cell Sci. 1999 Aug; 112 ( Pt 16):2677-91. Sieg DJ, Hauck CR, Schlaepfer DD. PMID: 10413676.
      View in: PubMed   Mentions: 230     Fields:    Translation:AnimalsCells
    98. Signaling through focal adhesion kinase. Prog Biophys Mol Biol. 1999; 71(3-4):435-78. Schlaepfer DD, Hauck CR, Sieg DJ. PMID: 10354709.
      View in: PubMed   Mentions: 357     Fields:    Translation:HumansAnimalsCells
    99. Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis. J Cell Biol. 1998 Oct 19; 143(2):547-60. Ilic D, Almeida EA, Schlaepfer DD, Dazin P, Aizawa S, Damsky CH. PMID: 9786962; PMCID: PMC2132850.
      View in: PubMed   Mentions: 146     Fields:    Translation:AnimalsCells
    100. Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration. EMBO J. 1998 Oct 15; 17(20):5933-47. Sieg DJ, Ilic D, Jones KC, Damsky CH, Hunter T, Schlaepfer DD. PMID: 9774338; PMCID: PMC1170921.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    101. Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events. Mol Cell Biol. 1998 May; 18(5):2571-85. Schlaepfer DD, Jones KC, Hunter T. PMID: 9566877; PMCID: PMC110637.
      View in: PubMed   Mentions: 121     Fields:    Translation:AnimalsCells
    102. Integrin signalling and tyrosine phosphorylation: just the FAKs? Trends Cell Biol. 1998 Apr; 8(4):151-7. Schlaepfer DD, Hunter T. PMID: 9695829.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    103. Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases. J Biol Chem. 1997 Nov 28; 272(48):30455-62. Li S, Kim M, Hu YL, Jalali S, Schlaepfer DD, Hunter T, Chien S, Shyy JY. PMID: 9374537.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
    104. Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src. J Biol Chem. 1997 May 16; 272(20):13189-95. Schlaepfer DD, Hunter T. PMID: 9148935.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    105. Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins. Mol Cell Biol. 1997 Mar; 17(3):1702-13. Schlaepfer DD, Broome MA, Hunter T. PMID: 9032297; PMCID: PMC231895.
      View in: PubMed   Mentions: 129     Fields:    Translation:AnimalsCells
    106. Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases. Mol Cell Biol. 1996 Oct; 16(10):5623-33. Schlaepfer DD, Hunter T. PMID: 8816475; PMCID: PMC231562.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansAnimalsCells
    107. Signal transduction from the extracellular matrix--a role for the focal adhesion protein-tyrosine kinase FAK. Cell Struct Funct. 1996 Oct; 21(5):445-50. Schlaepfer DD, Hunter T. PMID: 9118254.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    108. Calcium-dependent binding of S100C to the N-terminal domain of annexin I. J Biol Chem. 1996 Jan 12; 271(2):719-25. Mailliard WS, Haigler HT, Schlaepfer DD. PMID: 8557678.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    109. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature. 1994 Dec 22-29; 372(6508):786-91. Schlaepfer DD, Hanks SK, Hunter T, van der Geer P. PMID: 7997267.
      View in: PubMed   Mentions: 441     Fields:    Translation:HumansAnimalsCells
    110. Distinct cellular expression pattern of annexins in Hydra vulgaris. J Cell Biol. 1992 Aug; 118(4):911-28. Schlaepfer DD, Bode HR, Haigler HT. PMID: 1500430; PMCID: PMC2289573.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    111. Identification of a novel annexin in Hydra vulgaris. Characterization, cDNA cloning, and protein kinase C phosphorylation of annexin XII. J Biol Chem. 1992 May 15; 267(14):9529-39. Schlaepfer DD, Fisher DA, Brandt ME, Bode HR, Jones JM, Haigler HT. PMID: 1339458.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    112. Expression of annexins as a function of cellular growth state. J Cell Biol. 1990 Jul; 111(1):229-38. Schlaepfer DD, Haigler HT. PMID: 2142163; PMCID: PMC2116158.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    113. Purification and biochemical assay of synexin and of the homologous calcium-dependent membrane-binding proteins, endonexin II and lipocortin I. Methods Cell Biol. 1989; 31:207-27. Pollard HB, Burns AL, Rojas E, Schlaepfer DD, Haigler H, Brocklehurst K. PMID: 2528669.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    114. In vitro protein kinase C phosphorylation sites of placental lipocortin. Biochemistry. 1988 Jun 14; 27(12):4253-8. Schlaepfer DD, Haigler HT. PMID: 2971390.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    115. Characterization of lipocortin I and an immunologically unrelated 33-kDa protein as epidermal growth factor receptor/kinase substrates and phospholipase A2 inhibitors. J Biol Chem. 1987 May 15; 262(14):6921-30. Haigler HT, Schlaepfer DD, Burgess WH. PMID: 3032981.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    116. Epidermal growth factor dependent phosphorylation of a 35-kilodalton protein in placental membranes. Biochemistry. 1987 Feb 24; 26(4):1164-72. Sheets EE, Giugni TD, Coates GG, Schlaepfer DD, Haigler HT. PMID: 3105577.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
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