David Schlaepfer

Title(s)Professor, Ob/Gyn & Reproductive sciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Reprogramming the Tumor Microenvironment in Ovarian Cancer
    NIH R01CA254342Jul 3, 2020 - Jun 30, 2025
    Role: Principal Investigator
    New Mouse Model Investigating Endothelial Cell Suppression of Tumors
    NIH/NCI R21CA252417Jun 1, 2020 - May 31, 2022
    Role: Principal Investigator
    Dissecting FAK-regulated oncogenic signaling programs in ovarian cancer
    NIH R01CA247562May 1, 2020 - Apr 30, 2025
    Role: Principal Investigator
    Signaling Connections Controlling Cell Motility and Invasion
    NIH R01CA180769Jun 1, 2009 - Apr 30, 2019
    Role: Principal Investigator
    Genetic Analysis of FAK Activity
    NIH R01GM087400Jun 1, 2009 - May 31, 2013
    Role: Principal Investigator
    FAK Signals Controlling Endothelial Cell Survival and Motility
    NIH R01HL093156Sep 1, 2008 - Aug 31, 2013
    Role: Principal Investigator
    Role of FAK in Tumorigenesis
    NIH R01CA102310Jul 1, 2003 - Jun 30, 2020
    Role: Principal Investigator
    Role of FAK in Promoting Cell Motility
    NIH R01CA087038Jul 1, 2001 - Jun 30, 2007
    Role: Principal Investigator
    Tyrosine Phosphorylation in Integrin Signaling
    NIH R01CA075240Jul 1, 1997 - Sep 30, 2008
    Role: Principal Investigator
    TYROSINE PHOSPHORYLATION AND INTEGRIN SIGNALING
    NIH R29CA075240Jul 1, 1997 - Jun 30, 2002
    Role: Principal Investigator
    FUNCTIONAL ANALYSIS OF THE SH3 DOMAINS IN NCK
    NIH F32CA061721Jan 10, 1994
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Endothelial angiogenic activity and adipose angiogenesis is controlled by extracellular matrix protein TGFBI. Sci Rep. 2021 May 06; 11(1):9644. Lee SG, Kim JS, Kim HJ, Schlaepfer DD, Kim IS, Nam JO. PMID: 33958649.
      View in: PubMed   Mentions: 1     Fields:    
    2. Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair. Nat Commun. 2021 04 21; 12(1):2359. Zhou DW, Fernández-Yagüe MA, Holland EN, García AF, Castro NS, O'Neill EB, Eyckmans J, Chen CS, Fu J, Schlaepfer DD, García AJ. PMID: 33883558.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Targeting FAK in anticancer combination therapies. Nat Rev Cancer. 2021 05; 21(5):313-324. Dawson JC, Serrels A, Stupack DG, Schlaepfer DD, Frame MC. PMID: 33731845.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    4. FAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer. EMBO Mol Med. 2020 11 06; 12(11):e12010. Zaghdoudi S, Decaup E, Belhabib I, Samain R, Cassant-Sourdy S, Rochotte J, Brunel A, Schlaepfer D, Cros J, Neuzillet C, Strehaiano M, Alard A, Tomasini R, Rajeeve V, Perraud A, Mathonnet M, Pearce OM, Martineau Y, Pyronnet S, Bousquet C, Jean C. PMID: 33025708.
      View in: PubMed   Mentions: 9     Fields:    
    5. Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors. PLoS Genet. 2020 01; 16(1):e1008558. Delaney JR, Patel CB, Bapat J, Jones CM, Ramos-Zapatero M, Ortell KK, Tanios R, Haghighiabyaneh M, Axelrod J, DeStefano JW, Tancioni I, Schlaepfer DD, Harismendy O, La Spada AR, Stupack DG. PMID: 31923184.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    6. FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy. Elife. 2019 09 03; 8. Diaz Osterman CJ, Ozmadenci D, Kleinschmidt EG, Taylor KN, Barrie AM, Jiang S, Bean LM, Sulzmaier FJ, Jean C, Tancioni I, Anderson K, Uryu S, Cordasco EA, Li J, Chen XL, Fu G, Ojalill M, Rappu P, Heino J, Mark AM, Xu G, Fisch KM, Kolev VN, Weaver DT, Pachter JA, Gyorffy B, McHale MT, Connolly DC, Molinolo A, Stupack DG, Schlaepfer DD. PMID: 31478830.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    7. Rgnef promotes ovarian tumor progression and confers protection from oxidative stress. Oncogene. 2019 09; 38(36):6323-6337. Kleinschmidt EG, Miller NLG, Ozmadenci D, Tancioni I, Osterman CD, Barrie AM, Taylor KN, Ye A, Jiang S, Connolly DC, Stupack DG, Schlaepfer DD. PMID: 31308489.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    8. Nuclear Focal Adhesion Kinase Controls Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia Through GATA4-Mediated Cyclin D1 Transcription. Circ Res. 2019 07 05; 125(2):152-166. Jeong K, Kim JH, Murphy JM, Park H, Kim SJ, Rodriguez YAR, Kong H, Choi C, Guan JL, Taylor JM, Lincoln TM, Gerthoffer WT, Kim JS, Ahn EE, Schlaepfer DD, Lim SS. PMID: 31096851.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    9. A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK. Cancer Cell. 2019 03 18; 35(3):457-472.e5. Feng X, Arang N, Rigiracciolo DC, Lee JS, Yeerna H, Wang Z, Lubrano S, Kishore A, Pachter JA, König GM, Maggiolini M, Kostenis E, Schlaepfer DD, Tamayo P, Chen Q, Ruppin E, Gutkind JS. PMID: 30773340.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    10. Adaptive Resistance to Chemotherapy, A Multi-FAK-torial Linkage. . 2018 04; 17(4):719-723. Taylor KN, Schlaepfer DD. PMID: 29610281.
      View in: PubMed   Mentions:
    11. Focal adhesion kinase signaling in unexpected places. Curr Opin Cell Biol. 2017 04; 45:24-30. Kleinschmidt EG, Schlaepfer DD. PMID: 28213315.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    12. Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer. Nat Commun. 2017 02 15; 8:14423. Delaney JR, Patel CB, Willis KM, Haghighiabyaneh M, Axelrod J, Tancioni I, Lu D, Bapat J, Young S, Cadassou O, Bartakova A, Sheth P, Haft C, Hui S, Saenz C, Schlaepfer DD, Harismendy O, Stupack DG. PMID: 28198375.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    13. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med. 2016 05; 22(5):497-505. Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM. PMID: 27089513.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansAnimalsCells
    14. Oxidized LDL induces FAK-dependent RSK signaling to drive NF-?B activation and VCAM-1 expression. J Cell Sci. 2016 Apr 15; 129(8):1580-91. Yurdagul A, Sulzmaier FJ, Chen XL, Pattillo CB, Schlaepfer DD, Orr AW. PMID: 26906414.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    15. A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer. Oncotarget. 2015 Oct 13; 6(31):31104-18. Delaney JR, Patel C, McCabe KE, Lu D, Davis MA, Tancioni I, von Schalscha T, Bartakova A, Haft C, Schlaepfer DD, Stupack DG. PMID: 26418751.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    16. FAK/PYK2 promotes the Wnt/ß-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3ß. Elife. 2015 Sep 03; 4. Gao C, Chen G, Kuan SF, Zhang DH, Schlaepfer DD, Hu J. PMID: 26274564.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    17. Integrin a4 Enhances Metastasis and May Be Associated with Poor Prognosis in MYCN-low Neuroblastoma. PLoS One. 2015; 10(5):e0120815. Young SA, McCabe KE, Bartakova A, Delaney J, Pizzo DP, Newbury RO, Varner JA, Schlaepfer DD, Stupack DG. PMID: 25973900.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    18. Gastrin-stimulated Ga13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells. J Biol Chem. 2015 Jun 12; 290(24):15197-209. Masià-Balagué M, Izquierdo I, Garrido G, Cordomí A, Pérez-Benito L, Miller NL, Schlaepfer DD, Gigoux V, Aragay AM. PMID: 25922072.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    19. FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth. Breast Cancer Res. 2015 Mar 28; 17:47. Tancioni I, Miller NL, Uryu S, Lawson C, Jean C, Chen XL, Kleinschmidt EG, Schlaepfer DD. PMID: 25880415.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    20. FAK in cancer: mechanistic findings and clinical applications. Nat Rev Cancer. 2014 Sep; 14(9):598-610. Sulzmaier FJ, Jean C, Schlaepfer DD. PMID: 25098269.
      View in: PubMed   Mentions: 395     Fields:    Translation:HumansAnimalsCells
    21. FAK Inhibition disrupts a ß5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth. . 2014 Aug; 13(8):2050-61. Tancioni I, Uryu S, Sulzmaier FJ, Shah NR, Lawson C, Miller NL, Jean C, Chen XL, Ward KK, Schlaepfer DD. PMID: 24899686.
      View in: PubMed   Mentions:
    22. Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer. Gynecol Oncol. 2014 Jul; 134(1):104-11. Shah NR, Tancioni I, Ward KK, Lawson C, Chen XL, Jean C, Sulzmaier FJ, Uryu S, Miller NL, Connolly DC, Schlaepfer DD. PMID: 24786638.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    23. Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function. J Cell Biol. 2014 Jan 20; 204(2):247-63. Jean C, Chen XL, Nam JO, Tancioni I, Uryu S, Lawson C, Ward KK, Walsh CT, Miller NL, Ghassemian M, Turowski P, Dejana E, Weis S, Cheresh DA, Schlaepfer DD. PMID: 24446483.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    24. Grb2 promotes integrin-induced focal adhesion kinase (FAK) autophosphorylation and directs the phosphorylation of protein tyrosine phosphatase a by the Src-FAK kinase complex. Mol Cell Biol. 2014 Feb; 34(3):348-61. Cheng SY, Sun G, Schlaepfer DD, Pallen CJ. PMID: 24248601.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    25. pHocal adhesion kinase regulation is on a FERM foundation. J Cell Biol. 2013 Sep 16; 202(6):833-6. Lawson C, Schlaepfer DD. PMID: 24043698.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    26. A non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation. J Cell Sci. 2013 Nov 01; 126(Pt 21):5074-85. Miller NL, Lawson C, Kleinschmidt EG, Tancioni I, Uryu S, Schlaepfer DD. PMID: 24006257.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    27. Src-inducible association of CrkL with procaspase-8 promotes cell migration. Cell Adh Migr. 2013 Jul-Aug; 7(4):362-9. Graf R, Barbero S, Keller N, Chen L, Uryu S, Schlaepfer D, Stupack D. PMID: 23751956.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    28. Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression. Clin Exp Metastasis. 2013 Jun; 30(5):579-94. Ward KK, Tancioni I, Lawson C, Miller NL, Jean C, Chen XL, Uryu S, Kim J, Tarin D, Stupack DG, Plaxe SC, Schlaepfer DD. PMID: 23275034.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    29. Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells. J Cell Sci. 2012 Dec 15; 125(Pt 24):5960-73. Jung O, Choi S, Jang SB, Lee SA, Lim ST, Choi YJ, Kim HJ, Kim DH, Kwak TK, Kim H, Kang M, Lee MS, Park SY, Ryu J, Jeong D, Cheong HK, Kim HJ, Park KH, Lee BJ, Schlaepfer DD, Lee JW. PMID: 23077174.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    30. Cortactin as a target for FAK in the regulation of focal adhesion dynamics. PLoS One. 2012; 7(8):e44041. Tomar A, Lawson C, Ghassemian M, Schlaepfer DD. PMID: 22952866.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    31. Integrin adhesions: who's on first? What's on second? Connections between FAK and talin. Cell Adh Migr. 2012 Jul-Aug; 6(4):302-6. Lawson C, Schlaepfer DD. PMID: 22983197.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    32. Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression. J Cell Biol. 2012 Jun 25; 197(7):907-19. Lim ST, Miller NL, Chen XL, Tancioni I, Walsh CT, Lawson C, Uryu S, Weis SM, Cheresh DA, Schlaepfer DD. PMID: 22734001.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    33. Rgnef (p190RhoGEF) knockout inhibits RhoA activity, focal adhesion establishment, and cell motility downstream of integrins. PLoS One. 2012; 7(5):e37830. Miller NL, Lawson C, Chen XL, Lim ST, Schlaepfer DD. PMID: 22649559.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    34. EGFR-mediated carcinoma cell metastasis mediated by integrin avß5 depends on activation of c-Src and cleavage of MUC1. PLoS One. 2012; 7(5):e36753. Lau SK, Shields DJ, Murphy EA, Desgrosellier JS, Anand S, Huang M, Kato S, Lim ST, Weis SM, Stupack DG, Schlaepfer DD, Cheresh DA. PMID: 22586492.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    35. FAK promotes recruitment of talin to nascent adhesions to control cell motility. J Cell Biol. 2012 Jan 23; 196(2):223-32. Lawson C, Lim ST, Uryu S, Chen XL, Calderwood DA, Schlaepfer DD. PMID: 22270917.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    36. VEGF-induced vascular permeability is mediated by FAK. Dev Cell. 2012 Jan 17; 22(1):146-57. Chen XL, Nam JO, Jean C, Lawson C, Walsh CT, Goka E, Lim ST, Tomar A, Tancioni I, Uryu S, Guan JL, Acevedo LM, Weis SM, Cheresh DA, Schlaepfer DD. PMID: 22264731.
      View in: PubMed   Mentions: 135     Fields:    Translation:AnimalsCells
    37. Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells. J Cell Biol. 2011 Nov 28; 195(5):729-38. Li XY, Zhou X, Rowe RG, Hu Y, Schlaepfer DD, Ilic D, Dressler G, Park A, Guan JL, Weiss SJ. PMID: 22105351.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    38. Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer. Nat Commun. 2011 Jul 26; 2:406. Seong J, Ouyang M, Kim T, Sun J, Wen PC, Lu S, Zhuo Y, Llewellyn NM, Schlaepfer DD, Guan JL, Chien S, Wang Y. PMID: 21792185.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    39. p190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinase. Cancer Res. 2011 Jan 15; 71(2):360-70. Yu HG, Nam JO, Miller NL, Tanjoni I, Walsh C, Shi L, Kim L, Chen XL, Tomar A, Lim ST, Schlaepfer DD. PMID: 21224360.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    40. PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. . 2010 May 15; 9(10):764-77. Tanjoni I, Walsh C, Uryu S, Tomar A, Nam JO, Mielgo A, Lim ST, Liang C, Koenig M, Sun C, Patel N, Kwok C, McMahon G, Stupack DG, Schlaepfer DD. PMID: 20234191.
      View in: PubMed   Mentions:
    41. Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models. . 2010 May 15; 9(10):778-90. Walsh C, Tanjoni I, Uryu S, Tomar A, Nam JO, Luo H, Phillips A, Patel N, Kwok C, McMahon G, Stupack DG, Schlaepfer DD. PMID: 20234193.
      View in: PubMed   Mentions:
    42. Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation. J Biol Chem. 2010 Jul 09; 285(28):21526-36. Lim ST, Chen XL, Tomar A, Miller NL, Yoo J, Schlaepfer DD. PMID: 20442405.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    43. Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation. J Cell Biol. 2010 Mar 22; 188(6):877-90. Pasapera AM, Schneider IC, Rericha E, Schlaepfer DD, Waterman CM. PMID: 20308429.
      View in: PubMed   Mentions: 232     Fields:    Translation:AnimalsCells
    44. A PAK-activated linker for EGFR and FAK. Dev Cell. 2010 Feb 16; 18(2):170-2. Tomar A, Schlaepfer DD. PMID: 20159588.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    45. Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival. J Biol Chem. 2010 Jan 15; 285(3):1743-53. Lim ST, Miller NL, Nam JO, Chen XL, Lim Y, Schlaepfer DD. PMID: 19880522.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    46. Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility. Curr Opin Cell Biol. 2009 Oct; 21(5):676-83. Tomar A, Schlaepfer DD. PMID: 19525103.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    47. A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells. J Cell Sci. 2009 Jun 01; 122(Pt 11):1852-62. Tomar A, Lim ST, Lim Y, Schlaepfer DD. PMID: 19435801.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    48. Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis. Cancer Res. 2009 May 01; 69(9):3755-63. Barbero S, Mielgo A, Torres V, Teitz T, Shields DJ, Mikolon D, Bogyo M, Barilà D, Lahti JM, Schlaepfer D, Stupack DG. PMID: 19383910.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    49. Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motility. PLoS Pathog. 2009 Feb; 5(2):e1000304. Vomaske J, Melnychuk RM, Smith PP, Powell J, Hall L, DeFilippis V, Früh K, Smit M, Schlaepfer DD, Nelson JA, Streblow DN. PMID: 19229316.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    50. Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis. Cancer Res. 2009 Feb 15; 69(4):1383-91. Ricono JM, Huang M, Barnes LA, Lau SK, Weis SM, Schlaepfer DD, Hanks SK, Cheresh DA. PMID: 19208836.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    51. Establishment of cell lines from mouse embryos with early embryonic lethality. Cell Commun Adhes. 2008 Nov; 15(4):379-83. Howerton K, Schlaepfer DD, Ilic D. PMID: 18979299.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    52. FAK nuclear export signal sequences. FEBS Lett. 2008 Jul 09; 582(16):2402-6. Ossovskaya V, Lim ST, Ota N, Schlaepfer DD, Ilic D. PMID: 18549812.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    53. FERM control of FAK function: implications for cancer therapy. . 2008 Aug; 7(15):2306-14. Lim ST, Mikolon D, Stupack DG, Schlaepfer DD. PMID: 18677107.
      View in: PubMed   Mentions:
    54. Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK. J Cell Biol. 2008 Apr 07; 181(1):43-50. Weis SM, Lim ST, Lutu-Fuga KM, Barnes LA, Chen XL, Göthert JR, Shen TL, Guan JL, Schlaepfer DD, Cheresh DA. PMID: 18391070.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    55. Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol Cell. 2008 Jan 18; 29(1):9-22. Lim ST, Chen XL, Lim Y, Hanson DA, Vo TT, Howerton K, Larocque N, Fisher SJ, Schlaepfer DD, Ilic D. PMID: 18206965.
      View in: PubMed   Mentions: 202     Fields:    Translation:AnimalsCells
    56. PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility. J Cell Biol. 2008 Jan 14; 180(1):187-203. Lim Y, Lim ST, Tomar A, Gardel M, Bernard-Trifilo JA, Chen XL, Uryu SA, Canete-Soler R, Zhai J, Lin H, Schlaepfer WW, Nalbant P, Bokoch G, Ilic D, Waterman-Storer C, Schlaepfer DD. PMID: 18195107.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    57. Focal adhesion kinase controls pH-dependent epidermal barrier homeostasis by regulating actin-directed Na+/H+ exchanger 1 plasma membrane localization. Am J Pathol. 2007 Jun; 170(6):2055-67. Ilic D, Mao-Qiang M, Crumrine D, Dolganov G, Larocque N, Xu P, Demerjian M, Brown BE, Lim ST, Ossovskaya V, Schlaepfer DD, Fisher SJ, Feingold KR, Elias PM, Mauro TM. PMID: 17525272.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    58. Tumor necrosis factor-alpha stimulates focal adhesion kinase activity required for mitogen-activated kinase-associated interleukin 6 expression. J Biol Chem. 2007 Jun 15; 282(24):17450-9. Schlaepfer DD, Hou S, Lim ST, Tomar A, Yu H, Lim Y, Hanson DA, Uryu SA, Molina J, Mitra SK. PMID: 17438336.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    59. Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol. 2006 Oct; 18(5):516-23. Mitra SK, Schlaepfer DD. PMID: 16919435.
      View in: PubMed   Mentions: 620     Fields:    Translation:AnimalsCells
    60. Analyzing FAK and Pyk2 in early integrin signaling events. Curr Protoc Cell Biol. 2006 Apr; Chapter 14:Unit 14.7. Bernard-Trifilo JA, Lim ST, Hou S, Schlaepfer DD, Ilic D. PMID: 18228476.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    61. Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signaling pathway. Cancer Res. 2006 Jan 15; 66(2):775-83. Hu B, Jarzynka MJ, Guo P, Imanishi Y, Schlaepfer DD, Cheng SY. PMID: 16424009.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    62. FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion. J Cell Biol. 2005 Nov 07; 171(3):505-16. Benlimame N, He Q, Jie S, Xiao D, Xu YJ, Loignon M, Schlaepfer DD, Alaoui-Jamali MA. PMID: 16275754.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    63. Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src. Mol Cell Biol. 2005 Nov; 25(21):9700-12. Hsia DA, Lim ST, Bernard-Trifilo JA, Mitra SK, Tanaka S, den Hertog J, Streblow DN, Ilic D, Ginsberg MH, Schlaepfer DD. PMID: 16227616.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    64. alpha(v)beta3-integrin-dependent activation of focal adhesion kinase mediates NF-kappaB activation and motogenic activity by HIV-1 Tat in endothelial cells. J Cell Sci. 2005 Sep 01; 118(Pt 17):3949-58. Urbinati C, Bugatti A, Giacca M, Schlaepfer D, Presta M, Rusnati M. PMID: 16105876.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    65. Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol. 2005 Jan; 6(1):56-68. Mitra SK, Hanson DA, Schlaepfer DD. PMID: 15688067.
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    66. Control of motile and invasive cell phenotypes by focal adhesion kinase. Biochim Biophys Acta. 2004 Jul 05; 1692(2-3):77-102. Schlaepfer DD, Mitra SK, Ilic D. PMID: 15246681.
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    67. The cytoplasmic tyrosine kinase Pyk2 as a novel effector of fibroblast growth factor receptor 3 activation. J Biol Chem. 2004 Jul 02; 279(27):28450-7. Meyer AN, Gastwirt RF, Schlaepfer DD, Donoghue DJ. PMID: 15105428.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    68. Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling. Science. 2004 Feb 06; 303(5659):836-9. Palazzo AF, Eng CH, Schlaepfer DD, Marcantonio EE, Gundersen GG. PMID: 14764879.
      View in: PubMed   Mentions: 159     Fields:    Translation:AnimalsCells
    69. Multiple connections link FAK to cell motility and invasion. Curr Opin Genet Dev. 2004 Feb; 14(1):92-101. Schlaepfer DD, Mitra SK. PMID: 15108811.
      View in: PubMed   Mentions: 156     Fields:    Translation:Cells
    70. FAK promotes organization of fibronectin matrix and fibrillar adhesions. J Cell Sci. 2004 Jan 15; 117(Pt 2):177-87. Ilic D, Kovacic B, Johkura K, Schlaepfer DD, Tomasevic N, Han Q, Kim JB, Howerton K, Baumbusch C, Ogiwara N, Streblow DN, Nelson JA, Dazin P, Shino Y, Sasaki K, Damsky CH. PMID: 14657279.
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    71. Human cytomegalovirus chemokine receptor US28-induced smooth muscle cell migration is mediated by focal adhesion kinase and Src. J Biol Chem. 2003 Dec 12; 278(50):50456-65. Streblow DN, Vomaske J, Smith P, Melnychuk R, Hall L, Pancheva D, Smit M, Casarosa P, Schlaepfer DD, Nelson JA. PMID: 14506272.
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    72. Paxillin binding to the alpha 4 integrin subunit stimulates LFA-1 (integrin alpha L beta 2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2. J Immunol. 2003 Jun 15; 170(12):5912-8. Rose DM, Liu S, Woodside DG, Han J, Schlaepfer DD, Ginsberg MH. PMID: 12794117.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    73. Direct interaction of focal adhesion kinase with p190RhoGEF. J Biol Chem. 2003 Jul 04; 278(27):24865-73. Zhai J, Lin H, Nie Z, Wu J, Cañete-Soler R, Schlaepfer WW, Schlaepfer DD. PMID: 12702722.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    74. Differential regulation of cell motility and invasion by FAK. J Cell Biol. 2003 Mar 03; 160(5):753-67. Hsia DA, Mitra SK, Hauck CR, Streblow DN, Nelson JA, Ilic D, Huang S, Li E, Nemerow GR, Leng J, Spencer KS, Cheresh DA, Schlaepfer DD. PMID: 12615911.
      View in: PubMed   Mentions: 185     Fields:    Translation:AnimalsCells
    75. FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth. EMBO J. 2002 Dec 02; 21(23):6289-302. Hauck CR, Hsia DA, Puente XS, Cheresh DA, Schlaepfer DD. PMID: 12456636.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    76. Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. J Cell Biol. 2002 Apr 01; 157(1):149-60. Eliceiri BP, Puente XS, Hood JD, Stupack DG, Schlaepfer DD, Huang XZ, Sheppard D, Cheresh DA. PMID: 11927607.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansAnimalsCells
    77. v-Src SH3-enhanced interaction with focal adhesion kinase at beta 1 integrin-containing invadopodia promotes cell invasion. J Biol Chem. 2002 Apr 12; 277(15):12487-90. Hauck CR, Hsia DA, Ilic D, Schlaepfer DD. PMID: 11839732.
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    78. The focal adhesion kinase--a regulator of cell migration and invasion. IUBMB Life. 2002 Feb; 53(2):115-9. Hauck CR, Hsia DA, Schlaepfer DD. PMID: 12049193.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
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