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Rick Friedman

TitleClinical Professor
InstitutionUniversity of California San Diego
DepartmentSurgery
Address9300 Campus Point Drive #7895
La Jolla CA 92037
Phone858-657-5379
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    Collapse Research 
    Collapse Research Activities and Funding
    High-Resolution Mapping of Susceptibility Genes for NIHL
    NIH/NIDCD R01DC010856Feb 1, 2011 - Jan 31, 2016
    Role: Principal Investigator
    Genetic Analysis of Age Related Hearing Impairment
    NIH/NIDCD R01DC010215Sep 3, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Study of a genetic network involved in ear development
    NIH/NIDCD R01DC004796Sep 28, 2001 - Aug 31, 2007
    Role: Principal Investigator
    MOLECULAR GENETICS OF INNER EAR DEVELOPMENT
    NIH/NIDCD K08DC000119Jan 1, 1997 - Dec 31, 2001
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Schrauwen I, Kari E, Mattox J, Llaci L, Smeeton J, Naymik M, Raible DW, Knowles JA, Crump JG, Huentelman MJ, Friedman R. De novo variants in GREB1L are associated with non-syndromic inner ear malformations and deafness. Hum Genet. 2018 Jun 28. PMID: 29955957.
      View in: PubMed
    2. Babadjouni R, Wen T, Donoho DA, Buchanan IA, Cen SY, Friedman R, Amar A, Russin JJ, Giannotta SL, Mack WJ, Attenello FJ. Increased Hospital Surgical Volume Reduces Rate of 30- and 90-Day Readmission After Acoustic Neuroma Surgery. Neurosurgery. 2018 Jun 08. PMID: 29889284.
      View in: PubMed
    3. Tu NC, Friedman R. Age-related hearing loss: Unraveling the pieces. Laryngoscope Investig Otolaryngol. 2018 Apr; 3(2):68-72. PMID: 29721536.
      View in: PubMed
    4. Choi JS, Kari E, Friedman R, Fisher LM. Prevalence of Hearing Loss and Hearing Care Use Among Asian Americans: A Nationally Representative Sample. Otol Neurotol. 2018 Feb; 39(2):158-167. PMID: 29315179.
      View in: PubMed
    5. Salehi P, Ge MX, Gundimeda U, Michelle Baum L, Lael Cantu H, Lavinsky J, Tao L, Myint A, Cruz C, Wang J, Nikolakopoulou AM, Abdala C, Kelley MW, Ohyama T, Coate TM, Friedman R. Role of Neuropilin-1/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea. PLoS Genet. 2017 Oct; 13(10):e1007048. PMID: 29059194.
      View in: PubMed
    6. Kari E, Schrauwen I, Llaci L, Fisher LM, Go JL, Naymik M, Knowles JA, Huentelman MJ, Friedman R. Compound heterozygous mutations in MASP1 in a deaf child with absent cochlear nerves. Neurol Genet. 2017 Jun; 3(3):e153. PMID: 28534045.
      View in: PubMed
    7. Lavinsky J, Aaron KA, Christian E, Go JL, Hurth K, Giannotta SL, Friedman R. Solitary Plasmacytoma in the Internal Auditory Canal and Cerebellopontine Angle Mimicking Meningioma. Otol Neurotol. 2016 Dec; 37(10):e400-e401. PMID: 26457817.
      View in: PubMed
    8. Lavinsky J, Ge M, Crow AL, Pan C, Wang J, Salehi P, Myint A, Eskin E, Allayee H, Lusis AJ, Friedman R. The Genetic Architecture of Noise-Induced Hearing Loss: Evidence for a Gene-by-Environment Interaction. G3 (Bethesda). 2016 10 13; 6(10):3219-3228. PMID: 27520957.
      View in: PubMed
    9. Salehi P, Myint A, Kim YJ, Ge MX, Lavinsky J, Ho MK, Crow AL, Cruz C, Monges-Hernadez M, Wang J, Hartiala J, Zhang LI, Allayee H, Lusis AJ, Ohyama T, Friedman R. Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice. J Assoc Res Otolaryngol. 2016 Oct; 17(5):417-31. PMID: 27539716; PMCID: PMC5023540 [Available on 10/01/17].
      View in: PubMed, PubMed Central
    10. Myint A, White CH, Ohmen JD, Li X, Wang J, Lavinsky J, Salehi P, Crow AL, Ohyama T, Friedman R. Large-scale phenotyping of noise-induced hearing loss in 100 strains of mice. Hear Res. 2016 Feb; 332:113-120. PMID: 26706709; PMCID: PMC4769955 [Available on 02/01/17].
      View in: PubMed, PubMed Central
    11. Hoa M, Friedman R, Fisher LM, Derebery MJ. Prognostic implications of and audiometric evidence for hearing fluctuation in Meniere's disease. Laryngoscope. 2015 Dec; 125 Suppl 12:S1-12. PMID: 26343803.
      View in: PubMed
    12. Crow AL, Ohmen J, Wang J, Lavinsky J, Hartiala J, Li Q, Li X, Salehide P, Eskin E, Pan C, Lusis AJ, Allayee H, Friedman R. The Genetic Architecture of Hearing Impairment in Mice: Evidence for Frequency-Specific Genetic Determinants. G3 (Bethesda). 2015 Sep 04; 5(11):2329-39. PMID: 26342000; PMCID: PMC4632053.
      View in: PubMed, PubMed Central
    13. Schrauwen I, Hasin-Brumshtein Y, Corneveaux JJ, Ohmen J, White C, Allen AN, Lusis AJ, Van Camp G, Huentelman MJ, Friedman R. A comprehensive catalogue of the coding and non-coding transcripts of the human inner ear. Hear Res. 2016 Mar; 333:266-274. PMID: 26341477.
      View in: PubMed
    14. Lavinsky J, Crow AL, Pan C, Wang J, Aaron KA, Ho MK, Li Q, Salehide P, Myint A, Monges-Hernadez M, Eskin E, Allayee H, Lusis AJ, Friedman R. Correction: Genome-Wide Association Study Identifies Nox3 as a Critical Gene for Susceptibility to Noise-Induced Hearing Loss. PLoS Genet. 2015 Jun; 11(6):e1005293. PMID: 26068505; PMCID: PMC4465750.
      View in: PubMed, PubMed Central
    15. Lavinsky J, Crow AL, Pan C, Wang J, Aaron KA, Ho MK, Li Q, Salehide P, Myint A, Monges-Hernadez M, Eskin E, Allayee H, Lusis AJ, Friedman R. Genome-wide association study identifies nox3 as a critical gene for susceptibility to noise-induced hearing loss. PLoS Genet. 2015 Apr; 11(4):e1005094. PMID: 25880434; PMCID: PMC4399881.
      View in: PubMed, PubMed Central
    16. Aaron KA, Lavinsky J, Tuchman A, Go JL, Giannotta SL, Friedman R. A case report of two different skull base pathologies causing hearing loss in the same ear: vestibular schwannoma and superior semicircular canal dehiscence. Am J Otolaryngol. 2015 May-Jun; 36(3):488-91. PMID: 25720919.
      View in: PubMed
    17. Fransen E, Bonneux S, Corneveaux JJ, Schrauwen I, Di Berardino F, White CH, Ohmen JD, Van de Heyning P, Ambrosetti U, Huentelman MJ, Van Camp G, Friedman R. Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment. Eur J Hum Genet. 2015 Jan; 23(1):110-5. PMID: 24939585; PMCID: PMC4266741.
      View in: PubMed, PubMed Central
    18. Ohmen J, Kang EY, Li X, Joo JW, Hormozdiari F, Zheng QY, Davis RC, Lusis AJ, Eskin E, Friedman R. Genome-wide association study for age-related hearing loss (AHL) in the mouse: a meta-analysis. J Assoc Res Otolaryngol. 2014 Jun; 15(3):335-52. PMID: 24570207; PMCID: PMC4010595.
      View in: PubMed, PubMed Central
    19. Ho MK, Li X, Wang J, Ohmen JD, Friedman R. FVB/NJ mice demonstrate a youthful sensitivity to noise-induced hearing loss and provide a useful genetic model for the study of neural hearing loss. Audiol Neurotol Extra. 2014 Jan 01; 4(1):1-11. PMID: 24707282.
      View in: PubMed
    20. Fayad JN, Ursick J, Brackmann DE, Friedman R. Total ossiculoplasty: short- and long-term results using a titanium prosthesis with footplate shoe. Otol Neurotol. 2014 Jan; 35(1):108-13. PMID: 24270724.
      View in: PubMed
    21. Schwartz MS, Kari E, Strickland BM, Berliner K, Brackmann DE, House JW, Friedman R. Evaluation of the increased use of partial resection of large vestibular schwanommas: facial nerve outcomes and recurrence/regrowth rates. Otol Neurotol. 2013 Oct; 34(8):1456-64. PMID: 23928516.
      View in: PubMed
    22. Ohmen JD, White CH, Li X, Wang J, Fisher LM, Zhang H, Derebery MJ, Friedman R. Genetic evidence for an ethnic diversity in the susceptibility to Ménière's disease. Otol Neurotol. 2013 Sep; 34(7):1336-41. PMID: 23598705.
      View in: PubMed
    23. Rizk HG, Lorenz MB, Friedman R. Neuroglial heterotopia of the internal auditory canal. Otol Neurotol. 2013 Apr; 34(3):e22-3. PMID: 23449443.
      View in: PubMed
    24. Goddard JC, Go JL, Friedman R. Imaging case of the month: Fibrous dysplasia causing superior canal dehiscence. Otol Neurotol. 2013 Jan; 34(1):e1-2. PMID: 23187924.
      View in: PubMed
    25. Fisher LM, Derebery MJ, Friedman R. Oral steroid treatment for hearing improvement in Ménière's disease and endolymphatic hydrops. Otol Neurotol. 2012 Dec; 33(9):1685-91. PMID: 23047260.
      View in: PubMed
    26. Gázquez I, Moreno A, Requena T, Ohmen J, Santos-Perez S, Aran I, Soto-Varela A, Pérez-Garrigues H, López-Nevot A, Batuecas A, Friedman R, López-Nevot MA, López-Escamez JA. Functional variants of MIF, INFG and TFNA genes are not associated with disease susceptibility or hearing loss progression in patients with Ménière's disease. Eur Arch Otorhinolaryngol. 2013 Mar; 270(4):1521-9. PMID: 23179933.
      View in: PubMed
    27. Friedman R, Hoa M, Brackmann DE. Surgical management of endolymphatic sac tumors. J Neurol Surg B Skull Base. 2013 Feb; 74(1):12-9. PMID: 24436884; PMCID: PMC3699165.
      View in: PubMed, PubMed Central
    28. Newman DL, Fisher LM, Ohmen J, Parody R, Fong CT, Frisina ST, Mapes F, Eddins DA, Robert Frisina D, Frisina RD, Friedman R. GRM7 variants associated with age-related hearing loss based on auditory perception. Hear Res. 2012 Dec; 294(1-2):125-32. PMID: 23102807; PMCID: PMC3705704.
      View in: PubMed, PubMed Central
    29. Kari E, Friedman R. Hearing preservation: microsurgery. Curr Opin Otolaryngol Head Neck Surg. 2012 Oct; 20(5):358-66. PMID: 22929113.
      View in: PubMed
    30. Ghazalpour A, Rau CD, Farber CR, Bennett BJ, Orozco LD, van Nas A, Pan C, Allayee H, Beaven SW, Civelek M, Davis RC, Drake TA, Friedman R, Furlotte N, Hui ST, Jentsch JD, Kostem E, Kang HM, Kang EY, Joo JW, Korshunov VA, Laughlin RE, Martin LJ, Ohmen JD, Parks BW, Pellegrini M, Reue K, Smith DJ, Tetradis S, Wang J, Wang Y, Weiss JN, Kirchgessner T, Gargalovic PS, Eskin E, Lusis AJ, LeBoeuf RC. Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm Genome. 2012 Oct; 23(9-10):680-92. PMID: 22892838; PMCID: PMC3586763.
      View in: PubMed, PubMed Central
    31. Friedman R, Goddard JC, Wilkinson EP, Schwartz MS, Slattery WH, Fayad JN, Brackmann DE. Hearing preservation with the middle cranial fossa approach for neurofibromatosis type 2. Otol Neurotol. 2011 Dec; 32(9):1530-7. PMID: 21986931.
      View in: PubMed
    32. Friedman R, Berliner KI, Bassim M, Ursick J, Slattery WH, Schwartz MS, Brackmann DE. A paradigm shift in salvage surgery for radiated vestibular schwannoma. Otol Neurotol. 2011 Oct; 32(8):1322-8. PMID: 21897324.
      View in: PubMed
    33. Wilkinson EP, Hoa M, Slattery WH, Fayad JN, Friedman R, Schwartz MS, Brackmann DE. Evolution in the management of facial nerve schwannoma. Laryngoscope. 2011 Oct; 121(10):2065-74. PMID: 21898431.
      View in: PubMed
    34. Slattery WH, Hoa M, Bonne N, Friedman R, Schwartz MS, Fisher LM, Brackmann DE. Middle fossa decompression for hearing preservation: a review of institutional results and indications. Otol Neurotol. 2011 Aug; 32(6):1017-24. PMID: 21725256.
      View in: PubMed
    35. Goddard JC, Schwartz MS, Friedman R. Fundal fluid as a predictor of hearing preservation in the middle cranial fossa approach for vestibular schwannoma. Otol Neurotol. 2010 Sep; 31(7):1128-34. PMID: 20657334.
      View in: PubMed
    36. Bassim MK, Berliner KI, Fisher LM, Brackmann DE, Friedman R. Radiation therapy for the treatment of vestibular schwannoma: a critical evaluation of the state of the literature. Otol Neurotol. 2010 Jun; 31(4):567-73. PMID: 20300044.
      View in: PubMed
    37. White CH, Ohmen JD, Sheth S, Zebboudj AF, McHugh RK, Hoffman LF, Lusis AJ, Davis RC, Friedman R. Genome-wide screening for genetic loci associated with noise-induced hearing loss. Mamm Genome. 2009 Apr; 20(4):207-13. PMID: 19337678; PMCID: PMC2823581.
      View in: PubMed, PubMed Central
    38. Hilgert N, Monahan K, Kurima K, Li C, Friedman R, Griffith AJ, Van Camp G. Amino acid 572 in TMC1: hot spot or critical functional residue for dominant mutations causing hearing impairment. J Hum Genet. 2009 Mar; 54(3):188-90. PMID: 19180119.
      View in: PubMed
    39. Friedman R, Van Laer L, Huentelman MJ, Sheth SS, Van Eyken E, Corneveaux JJ, Tembe WD, Halperin RF, Thorburn AQ, Thys S, Bonneux S, Fransen E, Huyghe J, Pyykkö I, Cremers CW, Kremer H, Dhooge I, Stephens D, Orzan E, Pfister M, Bille M, Parving A, Sorri M, Van de Heyning PH, Makmura L, Ohmen JD, Linthicum FH, Fayad JN, Pearson JV, Craig DW, Stephan DA, Van Camp G. GRM7 variants confer susceptibility to age-related hearing impairment. Hum Mol Genet. 2009 Feb 15; 18(4):785-96. PMID: 19047183; PMCID: PMC2638831.
      View in: PubMed, PubMed Central
    40. Niu H, Li X, Makmura L, Friedman R. Mapping of genetic modifiers of Eya1 ( bor/bor ) in CAST/EiJ and BALB/cJ that suppress cochlear aplasia and associated deafness. Mamm Genome. 2008 Sep; 19(9):634-9. PMID: 18836772.
      View in: PubMed
    41. Wilkinson EP, Friedman R. Acute suppurative otitis media. Ear Nose Throat J. 2008 May; 87(5):250. PMID: 18572776.
      View in: PubMed
    42. Wilkinson EP, Liu GC, Friedman R. Correction of progressive hearing loss in superior canal dehiscence syndrome. Laryngoscope. 2008 Jan; 118(1):10-3. PMID: 18090259.
      View in: PubMed
    43. Kutz JW, Friedman R. Congenital middle ear cholesteatoma. Ear Nose Throat J. 2007 Nov; 86(11):654. PMID: 18225618.
      View in: PubMed
    44. Friedman R, Cullen RD, Ulis J, Brackmann DE. Management of cerebrospinal fluid leaks after acoustic tumor removal. Neurosurgery. 2007 Sep; 61(3 Suppl):35-9; discussion 39-40. PMID: 17876231.
      View in: PubMed
    45. Kutz JW, Verma S, Tan HT, Lo WW, Slattery WH, Friedman R. Surgical management of skull base chondroblastoma. Laryngoscope. 2007 May; 117(5):848-53. PMID: 17473681.
      View in: PubMed
    46. Slattery WH, Fisher LM, Hitselberger W, Friedman R, Brackmann DE. Hearing preservation surgery for neurofibromatosis Type 2-related vestibular schwannoma in pediatric patients. J Neurosurg. 2007 Apr; 106(4 Suppl):255-60. PMID: 17465357.
      View in: PubMed
    47. Starkweather A, Friedman R. Effect of ciprodex on graft healing in tympanoplasty. Adv Ther. 2007 Mar-Apr; 24(2):427-35. PMID: 17565934.
      View in: PubMed
    48. Doherty JK, Friedman R. Controversies in building a management algorithm for vestibular schwannomas. Curr Opin Otolaryngol Head Neck Surg. 2006 Oct; 14(5):305-13. PMID: 16974142.
      View in: PubMed
    49. McHugh RK, Friedman R. Genetics of hearing loss: Allelism and modifier genes produce a phenotypic continuum. Anat Rec A Discov Mol Cell Evol Biol. 2006 Apr; 288(4):370-81. PMID: 16550584.
      View in: PubMed
    50. Niu H, Makmura L, Shen T, Sheth SS, Blair K, Friedman R. Identification of two major loci that suppress hearing loss and cochlear dysmorphogenesis in Eya1bor/bor mice. Genomics. 2006 Sep; 88(3):302-8. PMID: 16488112.
      View in: PubMed
    51. Friedman R, Brackmann DE, Hitselberger WE, Schwartz MS, Iqbal Z, Berliner KI. Surgical salvage after failed irradiation for vestibular schwannoma. Laryngoscope. 2005 Oct; 115(10):1827-32. PMID: 16222204.
      View in: PubMed
    52. Slattery WH, Fisher LM, Iqbal Z, Friedman R, Liu N. Intratympanic steroid injection for treatment of idiopathic sudden hearing loss. Otolaryngol Head Neck Surg. 2005 Aug; 133(2):251-9. PMID: 16087024.
      View in: PubMed
    53. Cunningham CD, Friedman R, Brackmann DE, Hitselberger WE, Lin HW. Neurotologic skull base surgery in pediatric patients. Otol Neurotol. 2005 Mar; 26(2):231-6. PMID: 15793410.
      View in: PubMed
    54. Friedman R, Makmura L, Biesiada E, Wang X, Keithley EM. Eya1 acts upstream of Tbx1, Neurogenin 1, NeuroD and the neurotrophins BDNF and NT-3 during inner ear development. Mech Dev. 2005 May; 122(5):625-34. PMID: 15817220.
      View in: PubMed
    55. Zhang Y, Knosp BM, Maconochie M, Friedman R, Smith RJ. A comparative study of Eya1 and Eya4 protein function and its implication in branchio-oto-renal syndrome and DFNA10. J Assoc Res Otolaryngol. 2004 Sep; 5(3):295-304. PMID: 15492887; PMCID: PMC2504552.
      View in: PubMed, PubMed Central
    56. Shen T, Friedman R, Brackmann DE, Slattery WH, Hitselberger WE, Schwartz MS, Fisher L. The evolution of surgical approaches for posterior fossa meningiomas. Otol Neurotol. 2004 May; 25(3):394-7. PMID: 15129123.
      View in: PubMed
    57. Matz G, Rybak L, Roland PS, Hannley M, Friedman R, Manolidis S, Stewart MG, Weber P, Owens F. Ototoxicity of ototopical antibiotic drops in humans. Otolaryngol Head Neck Surg. 2004 Mar; 130(3 Suppl):S79-82. PMID: 15054365.
      View in: PubMed
    58. Roland PS, Stewart MG, Hannley M, Friedman R, Manolidis S, Matz G, Rybak L, Weber P, Owens F. Consensus panel on role of potentially ototoxic antibiotics for topical middle ear use: Introduction, methodology, and recommendations. Otolaryngol Head Neck Surg. 2004 Mar; 130(3 Suppl):S51-6. PMID: 15054363.
      View in: PubMed
    59. Roland PS, Rybak L, Hannley M, Matz G, Stewart MG, Manolidis S, Friedman R, Weber P, Owens F. Animal ototoxicity of topical antibiotics and the relevance to clinical treatment of human subjects. Otolaryngol Head Neck Surg. 2004 Mar; 130(3 Suppl):S57-78. PMID: 15054364.
      View in: PubMed
    60. Manolidis S, Friedman R, Hannley M, Roland PS, Matz G, Rybak L, Stewart MG, Weber P, Owens F. Comparative efficacy of aminoglycoside versus fluoroquinolone topical antibiotic drops. Otolaryngol Head Neck Surg. 2004 Mar; 130(3 Suppl):S83-8. PMID: 15054366.
      View in: PubMed
    61. Li X, Fischel-Ghodsian N, Schwartz F, Yan Q, Friedman R, Guan MX. Biochemical characterization of the mitochondrial tRNASer(UCN) T7511C mutation associated with nonsyndromic deafness. Nucleic Acids Res. 2004; 32(3):867-77. PMID: 14960712; PMCID: PMC373379.
      View in: PubMed, PubMed Central
    62. Friedman R, Kesser B, Brackmann DE, Fisher LM, Slattery WH, Hitselberger WE. Long-term hearing preservation after middle fossa removal of vestibular schwannoma. Otolaryngol Head Neck Surg. 2003 Dec; 129(6):660-5. PMID: 14663432.
      View in: PubMed
    63. Floyd JA, Gold DA, Concepcion D, Poon TH, Wang X, Keithley E, Chen D, Ward EJ, Chinn SB, Friedman R, Yu HT, Moriwaki K, Shiroishi T, Hamilton BA. A natural allele of Nxf1 suppresses retrovirus insertional mutations. Nat Genet. 2003 Nov; 35(3):221-8. PMID: 14517553; PMCID: PMC2756099.
      View in: PubMed, PubMed Central
    64. Li XC, Friedman R. Nonsyndromic hereditary hearing loss. Otolaryngol Clin North Am. 2002 Apr; 35(2):275-85. PMID: 12391618.
      View in: PubMed
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