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Rick Friedman

Title(s)Professor In Residence, Surgery
SchoolHealth Sciences
Address9300 Campus Point Drive #7895
La Jolla CA 92037
Phone858-657-5379
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    High-Resolution Mapping of Susceptibility Genes for NIHL
    NIH/NIDCD R01DC010856Feb 1, 2011 - Jul 17, 2013
    Role: Principal Investigator
    Genetic Analysis of Age Related Hearing Impairment
    NIH/NIDCD R01DC010215Sep 3, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Study of a genetic network involved in ear development
    NIH/NIDCD R01DC004796Sep 28, 2001 - Aug 31, 2007
    Role: Principal Investigator
    MOLECULAR GENETICS OF INNER EAR DEVELOPMENT
    NIH/NIDCD K08DC000119Jan 1, 1997 - Mar 31, 1998
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Genes Implicated in Rare Congenital Inner Ear and Cochleovestibular Nerve Malformations. Ear Hear. 2020 Jul/Aug; 41(4):983-989. Kari E, Llaci L, Go JL, Naymik M, Knowles JA, Leal SM, Rangasamy S, Huentelman MJ, Liang W, Friedman RA, Schrauwen I. PMID: 31985533.
      View in: PubMed   Mentions: 1     Fields:    
    2. What Genes Can Tell: A Closer Look at Vestibular Schwannoma. Otol Neurotol. 2020 Apr; 41(4):522-529. Aaron KA, Manojlovic Z, Tu N, Xu Y, Jin Y, Chang S, Kwok E, Webb M, Hurth K, Friedman RA. PMID: 32176142.
      View in: PubMed   Mentions:    Fields:    
    3. The Direct Costs of Microsurgical Resection of Vestibular Schwannomas. Otol Neurotol. 2020 Mar; 41(3):397-402. Saliba J, Mohammadzadeh A, Tawfik KO, Carriere JS, Schwartz MS, Nguyen QT, Friedman RA. PMID: 31868780.
      View in: PubMed   Mentions:    Fields:    
    4. A de novo SIX1 variant in a patient with a rare nonsyndromic cochleovestibular nerve abnormality, cochlear hypoplasia, and bilateral sensorineural hearing loss. Mol Genet Genomic Med. 2019 12; 7(12):e995. Kari E, Llaci L, Go JL, Naymik M, Knowles JA, Leal SM, Rangasamy S, Huentelman MJ, Friedman RA, Schrauwen I. PMID: 31595699.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Tophaceous Gout of the Middle Ear: Case Reports and Review of the Literature. Audiol Neurootol. 2019; 24(2):51-55. Saliba J, Sakano H, Friedman RA, Harris JP. PMID: 31167187.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Advances in understanding of presbycusis. J Neurosci Res. 2019 Apr 04. Tawfik KO, Klepper K, Saliba J, Friedman RA. PMID: 30950547.
      View in: PubMed   Mentions:    Fields:    
    7. Cochlear FLAIR Signal Changes in Hearing Preservation Vestibular Schwannoma Surgery. Otol Neurotol. 2019 03; 40(3):375-383. Tu NC, Bobarnac Dogaru G, Huang P, Kim J, Diegnan B, Go JL, Friedman RA. PMID: 30664035.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Intentional Subtotal Resection of Vestibular Schwannoma: A Reexamination. J Neurol Surg B Skull Base. 2020 Apr; 81(2):136-141. Strickland BA, Ravina K, Rennert RC, Jackanich A, Aaron K, Bakhsheshian J, Russin JJ, Friedman RA, Giannotta SL. PMID: 32206531.
      View in: PubMed   Mentions:
    9. Hearing Preservation in Vestibular Schwannoma Surgery. J Neurol Surg B Skull Base. 2019 Apr; 80(2):149-155. Saliba J, Friedman RA, Cueva RA. PMID: 30931222.
      View in: PubMed   Mentions:
    10. De novo variants in GREB1L are associated with non-syndromic inner ear malformations and deafness. Hum Genet. 2018 Jul; 137(6-7):459-470. Schrauwen I, Kari E, Mattox J, Llaci L, Smeeton J, Naymik M, Raible DW, Knowles JA, Crump JG, Huentelman MJ, Friedman RA. PMID: 29955957.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    11. Age-related hearing loss: Unraveling the pieces. Laryngoscope Investig Otolaryngol. 2018 Apr; 3(2):68-72. Tu NC, Friedman RA. PMID: 29721536.
      View in: PubMed   Mentions:
    12. Prevalence of Hearing Loss and Hearing Care Use Among Asian Americans: A Nationally Representative Sample. Otol Neurotol. 2018 02; 39(2):158-167. Choi JS, Kari E, Friedman RA, Fisher LM. PMID: 29315179.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Role of Neuropilin-1/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea. PLoS Genet. 2017 Oct; 13(10):e1007048. Salehi P, Ge MX, Gundimeda U, Michelle Baum L, Lael Cantu H, Lavinsky J, Tao L, Myint A, Cruz C, Wang J, Nikolakopoulou AM, Abdala C, Kelley MW, Ohyama T, Coate TM, Friedman RA. PMID: 29059194.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    14. Compound heterozygous mutations in MASP1 in a deaf child with absent cochlear nerves. Neurol Genet. 2017 Jun; 3(3):e153. Kari E, Schrauwen I, Llaci L, Fisher LM, Go JL, Naymik M, Knowles JA, Huentelman MJ, Friedman RA. PMID: 28534045.
      View in: PubMed   Mentions:
    15. Solitary Plasmacytoma in the Internal Auditory Canal and Cerebellopontine Angle Mimicking Meningioma. Otol Neurotol. 2016 Dec; 37(10):e400-e401. Lavinsky J, Aaron KA, Christian E, Go JL, Hurth K, Giannotta SL, Friedman RA. PMID: 26457817.
      View in: PubMed   Mentions: 1     Fields:    
    16. Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice. J Assoc Res Otolaryngol. 2016 Oct; 17(5):417-31. Salehi P, Myint A, Kim YJ, Ge MX, Lavinsky J, Ho MK, Crow AL, Cruz C, Monges-Hernadez M, Wang J, Hartiala J, Zhang LI, Allayee H, Lusis AJ, Ohyama T, Friedman RA. PMID: 27539716.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    17. Prognostic implications of and audiometric evidence for hearing fluctuation in Meniere's disease. Laryngoscope. 2015 Dec; 125 Suppl 12:S1-12. Hoa M, Friedman RA, Fisher LM, Derebery MJ. PMID: 26343803.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    18. A comprehensive catalogue of the coding and non-coding transcripts of the human inner ear. Hear Res. 2016 Mar; 333:266-274. Schrauwen I, Hasin-Brumshtein Y, Corneveaux JJ, Ohmen J, White C, Allen AN, Lusis AJ, Van Camp G, Huentelman MJ, Friedman RA. PMID: 26341477.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    19. Genome-wide association study identifies nox3 as a critical gene for susceptibility to noise-induced hearing loss. PLoS Genet. 2015 Apr; 11(4):e1005094. Lavinsky J, Crow AL, Pan C, Wang J, Aaron KA, Ho MK, Li Q, Salehide P, Myint A, Monges-Hernadez M, Eskin E, Allayee H, Lusis AJ, Friedman RA. PMID: 25880434.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    20. A case report of two different skull base pathologies causing hearing loss in the same ear: vestibular schwannoma and superior semicircular canal dehiscence. Am J Otolaryngol. 2015 May-Jun; 36(3):488-91. Aaron KA, Lavinsky J, Tuchman A, Go JL, Giannotta SL, Friedman RA. PMID: 25720919.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment. Eur J Hum Genet. 2015 Jan; 23(1):110-5. Fransen E, Bonneux S, Corneveaux JJ, Schrauwen I, Di Berardino F, White CH, Ohmen JD, Van de Heyning P, Ambrosetti U, Huentelman MJ, Van Camp G, Friedman RA. PMID: 24939585.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    22. Total ossiculoplasty: short- and long-term results using a titanium prosthesis with footplate shoe. Otol Neurotol. 2014 Jan; 35(1):108-13. Fayad JN, Ursick J, Brackmann DE, Friedman RA. PMID: 24270724.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Evaluation of the increased use of partial resection of large vestibular schwanommas: facial nerve outcomes and recurrence/regrowth rates. Otol Neurotol. 2013 Oct; 34(8):1456-64. Schwartz MS, Kari E, Strickland BM, Berliner K, Brackmann DE, House JW, Friedman RA. PMID: 23928516.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    24. Genetic evidence for an ethnic diversity in the susceptibility to Ménière's disease. Otol Neurotol. 2013 Sep; 34(7):1336-41. Ohmen JD, White CH, Li X, Wang J, Fisher LM, Zhang H, Derebery MJ, Friedman RA. PMID: 23598705.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    25. Neuroglial heterotopia of the internal auditory canal. Otol Neurotol. 2013 Apr; 34(3):e22-3. Rizk HG, Lorenz MB, Friedman R. PMID: 23449443.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    26. Imaging case of the month: Fibrous dysplasia causing superior canal dehiscence. Otol Neurotol. 2013 Jan; 34(1):e1-2. Goddard JC, Go JL, Friedman RA. PMID: 23187924.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. Oral steroid treatment for hearing improvement in Ménière's disease and endolymphatic hydrops. Otol Neurotol. 2012 Dec; 33(9):1685-91. Fisher LM, Derebery MJ, Friedman RA. PMID: 23047260.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    28. Surgical management of endolymphatic sac tumors. J Neurol Surg B Skull Base. 2013 Feb; 74(1):12-9. Friedman RA, Hoa M, Brackmann DE. PMID: 24436884.
      View in: PubMed   Mentions:
    29. Hearing preservation: microsurgery. Curr Opin Otolaryngol Head Neck Surg. 2012 Oct; 20(5):358-66. Kari E, Friedman RA. PMID: 22929113.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    30. Hearing preservation with the middle cranial fossa approach for neurofibromatosis type 2. Otol Neurotol. 2011 Dec; 32(9):1530-7. Friedman RA, Goddard JC, Wilkinson EP, Schwartz MS, Slattery WH, Fayad JN, Brackmann DE. PMID: 21986931.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    31. A paradigm shift in salvage surgery for radiated vestibular schwannoma. Otol Neurotol. 2011 Oct; 32(8):1322-8. Friedman RA, Berliner KI, Bassim M, Ursick J, Slattery WH, Schwartz MS, Brackmann DE. PMID: 21897324.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    32. Evolution in the management of facial nerve schwannoma. Laryngoscope. 2011 Oct; 121(10):2065-74. Wilkinson EP, Hoa M, Slattery WH, Fayad JN, Friedman RA, Schwartz MS, Brackmann DE. PMID: 21898431.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    33. Middle fossa decompression for hearing preservation: a review of institutional results and indications. Otol Neurotol. 2011 Aug; 32(6):1017-24. Slattery WH, Hoa M, Bonne N, Friedman RA, Schwartz MS, Fisher LM, Brackmann DE. PMID: 21725256.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    34. Fundal fluid as a predictor of hearing preservation in the middle cranial fossa approach for vestibular schwannoma. Otol Neurotol. 2010 Sep; 31(7):1128-34. Goddard JC, Schwartz MS, Friedman RA. PMID: 20657334.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    35. Radiation therapy for the treatment of vestibular schwannoma: a critical evaluation of the state of the literature. Otol Neurotol. 2010 Jun; 31(4):567-73. Bassim MK, Berliner KI, Fisher LM, Brackmann DE, Friedman RA. PMID: 20300044.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    36. GRM7 variants confer susceptibility to age-related hearing impairment. Hum Mol Genet. 2009 Feb 15; 18(4):785-96. Friedman RA, Van Laer L, Huentelman MJ, Sheth SS, Van Eyken E, Corneveaux JJ, Tembe WD, Halperin RF, Thorburn AQ, Thys S, Bonneux S, Fransen E, Huyghe J, Pyykkö I, Cremers CW, Kremer H, Dhooge I, Stephens D, Orzan E, Pfister M, Bille M, Parving A, Sorri M, Van de Heyning PH, Makmura L, Ohmen JD, Linthicum FH, Fayad JN, Pearson JV, Craig DW, Stephan DA, Van Camp G. PMID: 19047183.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimals
    37. Mapping of genetic modifiers of Eya1 ( bor/bor ) in CAST/EiJ and BALB/cJ that suppress cochlear aplasia and associated deafness. Mamm Genome. 2008 Sep; 19(9):634-9. Niu H, Li X, Makmura L, Friedman RA. PMID: 18836772.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    38. Hearing preservation surgery for neurofibromatosis Type 2-related vestibular schwannoma in pediatric patients. J Neurosurg. 2007 Apr; 106(4 Suppl):255-60. Slattery WH, Fisher LM, Hitselberger W, Friedman RA, Brackmann DE. PMID: 17465357.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    39. Identification of two major loci that suppress hearing loss and cochlear dysmorphogenesis in Eya1bor/bor mice. Genomics. 2006 Sep; 88(3):302-8. Niu H, Makmura L, Shen T, Sheth SS, Blair K, Friedman RA. PMID: 16488112.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    40. Surgical salvage after failed irradiation for vestibular schwannoma. Laryngoscope. 2005 Oct; 115(10):1827-32. Friedman RA, Brackmann DE, Hitselberger WE, Schwartz MS, Iqbal Z, Berliner KI. PMID: 16222204.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    41. Neurotologic skull base surgery in pediatric patients. Otol Neurotol. 2005 Mar; 26(2):231-6. Cunningham CD, Friedman RA, Brackmann DE, Hitselberger WE, Lin HW. PMID: 15793410.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    42. Eya1 acts upstream of Tbx1, Neurogenin 1, NeuroD and the neurotrophins BDNF and NT-3 during inner ear development. Mech Dev. 2005 May; 122(5):625-34. Friedman RA, Makmura L, Biesiada E, Wang X, Keithley EM. PMID: 15817220.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    43. The evolution of surgical approaches for posterior fossa meningiomas. Otol Neurotol. 2004 May; 25(3):394-7. Shen T, Friedman RA, Brackmann DE, Slattery WH, Hitselberger WE, Schwartz MS, Fisher L. PMID: 15129123.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    44. Biochemical characterization of the mitochondrial tRNASer(UCN) T7511C mutation associated with nonsyndromic deafness. Nucleic Acids Res. 2004; 32(3):867-77. Li X, Fischel-Ghodsian N, Schwartz F, Yan Q, Friedman RA, Guan MX. PMID: 14960712.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    45. Long-term hearing preservation after middle fossa removal of vestibular schwannoma. Otolaryngol Head Neck Surg. 2003 Dec; 129(6):660-5. Friedman RA, Kesser B, Brackmann DE, Fisher LM, Slattery WH, Hitselberger WE. PMID: 14663432.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    46. A natural allele of Nxf1 suppresses retrovirus insertional mutations. Nat Genet. 2003 Nov; 35(3):221-8. Floyd JA, Gold DA, Concepcion D, Poon TH, Wang X, Keithley E, Chen D, Ward EJ, Chinn SB, Friedman RA, Yu HT, Moriwaki K, Shiroishi T, Hamilton BA. PMID: 14517553.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    47. Nonsyndromic hereditary hearing loss. Otolaryngol Clin North Am. 2002 Apr; 35(2):275-85. Li XC, Friedman RA. PMID: 12391618.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    48. Prognostic factors for hearing preservation in vestibular schwannoma surgery. Am J Otol. 2000 May; 21(3):417-24. Brackmann DE, Owens RM, Friedman RA, Hitselberger WE, De la Cruz A, House JW, Nelson RA, Luxford WM, Slattery WH, Fayad JN. PMID: 10821558.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    49. Identification and mutation analysis of a cochlear-expressed, zinc finger protein gene at the DFNB7/11 and dn hearing-loss loci on human chromosome 9q and mouse chromosome 19. Gene. 1998 Jul 30; 215(2):461-9. Scott DA, Greinwald JH, Marietta JR, Drury S, Swiderski RE, Viñas A, DeAngelis MM, Carmi R, Ramesh A, Kraft ML, Elbedour K, Skworak AB, Friedman RA, Srikumari Srisailapathy CR, Verhoeven K, Van Gamp G, Lovett M, Deininger PL, Batzer MA, Morton CC, Keats BJ, Smith RJ, Sheffield VC. PMID: 9758550.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    50. The role of endolymphatic mastoid shunt surgery in the managed care era. Am J Otol. 1998 May; 19(3):337-40. Pensak ML, Friedman RA. PMID: 9596185.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    51. Fallopian bridge technique in surgery for chronic ear disease. Laryngoscope. 1997 Nov; 107(11 Pt 1):1451-6. Pensak ML, Friedman RA. PMID: 9369389.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    52. Anterior petrosectomy approach to infraclinoidal basilar artery aneurysms: the emerging role of the neuro-otologist in multidisciplinary management of basilar artery aneurysms. Laryngoscope. 1997 Jul; 107(7):977-83. Friedman RA, Pensak ML, Tauber M, Tew JM, van Loveren HR. PMID: 9217142.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    53. Posterior fossa meningiomas intimately involved with the endolymphatic sac. Am J Otol. 1996 Jul; 17(4):612-6. Friedman RA, Nelson RA, Harris JP. PMID: 8841708.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    54. Nager acrofacial dysostosis: management of a difficult airway. Int J Pediatr Otorhinolaryngol. 1996 Mar; 35(1):69-72. Friedman RA, Wood E, Pransky SM, Seid AB, Kearns DB. PMID: 8882111.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    55. Transgenic insertional mutagenesis. Applications to inner-ear genetics. Arch Otolaryngol Head Neck Surg. 1996 Mar; 122(3):252-7. Friedman RA. PMID: 8607951.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    56. Transgenic mice. Current applications to the study of the auditory and vestibular systems. Otolaryngol Clin North Am. 1992 Oct; 25(5):1017-26. Friedman RA, Ryan AF. PMID: 1408190.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    57. Sinusitis. Annu Rev Med. 1991; 42:471-89. Friedman RA, Harris JP. PMID: 2035989.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
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