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Rick Friedman

Title(s)Professor In Residence, Surgery
SchoolHealth Sciences
Phone858-657-5379
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    Collapse Research 
    Collapse Research Activities and Funding
    High-Resolution Mapping of Susceptibility Genes for NIHL
    NIH/NIDCD R01DC010856Feb 1, 2011 - Jul 17, 2013
    Role: Principal Investigator
    Genetic Analysis of Age Related Hearing Impairment
    NIH/NIDCD R01DC010215Sep 3, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Study of a genetic network involved in ear development
    NIH/NIDCD R01DC004796Sep 28, 2001 - Aug 31, 2007
    Role: Principal Investigator
    MOLECULAR GENETICS OF INNER EAR DEVELOPMENT
    NIH/NIDCD K08DC000119Jan 1, 1997 - Mar 31, 1998
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Aaron KA, Manojlovic Z, Tu N, Xu Y, Jin Y, Chang S, Kwok E, Webb M, Hurth K, Friedman RA. What Genes Can Tell: A Closer Look at Vestibular Schwannoma. Otol Neurotol. 2020 Apr; 41(4):522-529. PMID: 32176142.
      View in: PubMed
    2. Saliba J, Mohammadzadeh A, Tawfik KO, Carriere JS, Schwartz MS, Nguyen QT, Friedman RA. The Direct Costs of Microsurgical Resection of Vestibular Schwannomas. Otol Neurotol. 2020 Mar; 41(3):397-402. PMID: 31868780.
      View in: PubMed
    3. Kari E, Llaci L, Go JL, Naymik M, Knowles JA, Leal SM, Rangasamy S, Huentelman MJ, Liang W, Friedman RA, Schrauwen I. Genes Implicated in Rare Congenital Inner Ear and Cochleovestibular Nerve Malformations. Ear Hear. 2020 Jan 24. PMID: 31985533.
      View in: PubMed
    4. Kari E, Llaci L, Go JL, Naymik M, Knowles JA, Leal SM, Rangasamy S, Huentelman MJ, Friedman RA, Schrauwen I. A de novo SIX1 variant in a patient with a rare nonsyndromic cochleovestibular nerve abnormality, cochlear hypoplasia, and bilateral sensorineural hearing loss. Mol Genet Genomic Med. 2019 12; 7(12):e995. PMID: 31595699.
      View in: PubMed
    5. Saliba J, Sakano H, Friedman RA, Harris JP. Tophaceous Gout of the Middle Ear: Case Reports and Review of the Literature. Audiol Neurootol. 2019; 24(2):51-55. PMID: 31167187.
      View in: PubMed
    6. Tawfik KO, Klepper K, Saliba J, Friedman RA. Advances in understanding of presbycusis. J Neurosci Res. 2019 Apr 04. PMID: 30950547.
      View in: PubMed
    7. Tu NC, Bobarnac Dogaru G, Huang P, Kim J, Diegnan B, Go JL, Friedman RA. Cochlear FLAIR Signal Changes in Hearing Preservation Vestibular Schwannoma Surgery. Otol Neurotol. 2019 03; 40(3):375-383. PMID: 30664035.
      View in: PubMed
    8. Strickland BA, Ravina K, Rennert RC, Jackanich A, Aaron K, Bakhsheshian J, Russin JJ, Friedman RA, Giannotta SL. Intentional Subtotal Resection of Vestibular Schwannoma: A Reexamination. J Neurol Surg B Skull Base. 2020 Apr; 81(2):136-141. PMID: 32206531.
      View in: PubMed
    9. Saliba J, Friedman RA, Cueva RA. Hearing Preservation in Vestibular Schwannoma Surgery. J Neurol Surg B Skull Base. 2019 Apr; 80(2):149-155. PMID: 30931222.
      View in: PubMed
    10. Schrauwen I, Kari E, Mattox J, Llaci L, Smeeton J, Naymik M, Raible DW, Knowles JA, Crump JG, Huentelman MJ, Friedman RA. De novo variants in GREB1L are associated with non-syndromic inner ear malformations and deafness. Hum Genet. 2018 Jul; 137(6-7):459-470. PMID: 29955957.
      View in: PubMed
    11. Tu NC, Friedman RA. Age-related hearing loss: Unraveling the pieces. Laryngoscope Investig Otolaryngol. 2018 Apr; 3(2):68-72. PMID: 29721536.
      View in: PubMed
    12. Choi JS, Kari E, Friedman RA, Fisher LM. Prevalence of Hearing Loss and Hearing Care Use Among Asian Americans: A Nationally Representative Sample. Otol Neurotol. 2018 02; 39(2):158-167. PMID: 29315179.
      View in: PubMed
    13. Salehi P, Ge MX, Gundimeda U, Michelle Baum L, Lael Cantu H, Lavinsky J, Tao L, Myint A, Cruz C, Wang J, Nikolakopoulou AM, Abdala C, Kelley MW, Ohyama T, Coate TM, Friedman RA. Role of Neuropilin-1/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea. PLoS Genet. 2017 Oct; 13(10):e1007048. PMID: 29059194.
      View in: PubMed
    14. Kari E, Schrauwen I, Llaci L, Fisher LM, Go JL, Naymik M, Knowles JA, Huentelman MJ, Friedman RA. Compound heterozygous mutations in MASP1 in a deaf child with absent cochlear nerves. Neurol Genet. 2017 Jun; 3(3):e153. PMID: 28534045.
      View in: PubMed
    15. Lavinsky J, Aaron KA, Christian E, Go JL, Hurth K, Giannotta SL, Friedman RA. Solitary Plasmacytoma in the Internal Auditory Canal and Cerebellopontine Angle Mimicking Meningioma. Otol Neurotol. 2016 Dec; 37(10):e400-e401. PMID: 26457817.
      View in: PubMed
    16. Salehi P, Myint A, Kim YJ, Ge MX, Lavinsky J, Ho MK, Crow AL, Cruz C, Monges-Hernadez M, Wang J, Hartiala J, Zhang LI, Allayee H, Lusis AJ, Ohyama T, Friedman RA. Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice. J Assoc Res Otolaryngol. 2016 Oct; 17(5):417-31. PMID: 27539716.
      View in: PubMed
    17. Hoa M, Friedman RA, Fisher LM, Derebery MJ. Prognostic implications of and audiometric evidence for hearing fluctuation in Meniere's disease. Laryngoscope. 2015 Dec; 125 Suppl 12:S1-12. PMID: 26343803.
      View in: PubMed
    18. Schrauwen I, Hasin-Brumshtein Y, Corneveaux JJ, Ohmen J, White C, Allen AN, Lusis AJ, Van Camp G, Huentelman MJ, Friedman RA. A comprehensive catalogue of the coding and non-coding transcripts of the human inner ear. Hear Res. 2016 Mar; 333:266-274. PMID: 26341477.
      View in: PubMed
    19. Lavinsky J, Crow AL, Pan C, Wang J, Aaron KA, Ho MK, Li Q, Salehide P, Myint A, Monges-Hernadez M, Eskin E, Allayee H, Lusis AJ, Friedman RA. Genome-wide association study identifies nox3 as a critical gene for susceptibility to noise-induced hearing loss. PLoS Genet. 2015 Apr; 11(4):e1005094. PMID: 25880434.
      View in: PubMed
    20. Aaron KA, Lavinsky J, Tuchman A, Go JL, Giannotta SL, Friedman RA. A case report of two different skull base pathologies causing hearing loss in the same ear: vestibular schwannoma and superior semicircular canal dehiscence. Am J Otolaryngol. 2015 May-Jun; 36(3):488-91. PMID: 25720919.
      View in: PubMed
    21. Fransen E, Bonneux S, Corneveaux JJ, Schrauwen I, Di Berardino F, White CH, Ohmen JD, Van de Heyning P, Ambrosetti U, Huentelman MJ, Van Camp G, Friedman RA. Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment. Eur J Hum Genet. 2015 Jan; 23(1):110-5. PMID: 24939585.
      View in: PubMed
    22. Fayad JN, Ursick J, Brackmann DE, Friedman RA. Total ossiculoplasty: short- and long-term results using a titanium prosthesis with footplate shoe. Otol Neurotol. 2014 Jan; 35(1):108-13. PMID: 24270724.
      View in: PubMed
    23. Schwartz MS, Kari E, Strickland BM, Berliner K, Brackmann DE, House JW, Friedman RA. Evaluation of the increased use of partial resection of large vestibular schwanommas: facial nerve outcomes and recurrence/regrowth rates. Otol Neurotol. 2013 Oct; 34(8):1456-64. PMID: 23928516.
      View in: PubMed
    24. Ohmen JD, White CH, Li X, Wang J, Fisher LM, Zhang H, Derebery MJ, Friedman RA. Genetic evidence for an ethnic diversity in the susceptibility to Ménière's disease. Otol Neurotol. 2013 Sep; 34(7):1336-41. PMID: 23598705.
      View in: PubMed
    25. Rizk HG, Lorenz MB, Friedman R. Neuroglial heterotopia of the internal auditory canal. Otol Neurotol. 2013 Apr; 34(3):e22-3. PMID: 23449443.
      View in: PubMed
    26. Goddard JC, Go JL, Friedman RA. Imaging case of the month: Fibrous dysplasia causing superior canal dehiscence. Otol Neurotol. 2013 Jan; 34(1):e1-2. PMID: 23187924.
      View in: PubMed
    27. Fisher LM, Derebery MJ, Friedman RA. Oral steroid treatment for hearing improvement in Ménière's disease and endolymphatic hydrops. Otol Neurotol. 2012 Dec; 33(9):1685-91. PMID: 23047260.
      View in: PubMed
    28. Friedman RA, Hoa M, Brackmann DE. Surgical management of endolymphatic sac tumors. J Neurol Surg B Skull Base. 2013 Feb; 74(1):12-9. PMID: 24436884.
      View in: PubMed
    29. Kari E, Friedman RA. Hearing preservation: microsurgery. Curr Opin Otolaryngol Head Neck Surg. 2012 Oct; 20(5):358-66. PMID: 22929113.
      View in: PubMed
    30. Friedman RA, Goddard JC, Wilkinson EP, Schwartz MS, Slattery WH, Fayad JN, Brackmann DE. Hearing preservation with the middle cranial fossa approach for neurofibromatosis type 2. Otol Neurotol. 2011 Dec; 32(9):1530-7. PMID: 21986931.
      View in: PubMed
    31. Friedman RA, Berliner KI, Bassim M, Ursick J, Slattery WH, Schwartz MS, Brackmann DE. A paradigm shift in salvage surgery for radiated vestibular schwannoma. Otol Neurotol. 2011 Oct; 32(8):1322-8. PMID: 21897324.
      View in: PubMed
    32. Wilkinson EP, Hoa M, Slattery WH, Fayad JN, Friedman RA, Schwartz MS, Brackmann DE. Evolution in the management of facial nerve schwannoma. Laryngoscope. 2011 Oct; 121(10):2065-74. PMID: 21898431.
      View in: PubMed
    33. Slattery WH, Hoa M, Bonne N, Friedman RA, Schwartz MS, Fisher LM, Brackmann DE. Middle fossa decompression for hearing preservation: a review of institutional results and indications. Otol Neurotol. 2011 Aug; 32(6):1017-24. PMID: 21725256.
      View in: PubMed
    34. Goddard JC, Schwartz MS, Friedman RA. Fundal fluid as a predictor of hearing preservation in the middle cranial fossa approach for vestibular schwannoma. Otol Neurotol. 2010 Sep; 31(7):1128-34. PMID: 20657334.
      View in: PubMed
    35. Bassim MK, Berliner KI, Fisher LM, Brackmann DE, Friedman RA. Radiation therapy for the treatment of vestibular schwannoma: a critical evaluation of the state of the literature. Otol Neurotol. 2010 Jun; 31(4):567-73. PMID: 20300044.
      View in: PubMed
    36. Friedman RA, Van Laer L, Huentelman MJ, Sheth SS, Van Eyken E, Corneveaux JJ, Tembe WD, Halperin RF, Thorburn AQ, Thys S, Bonneux S, Fransen E, Huyghe J, Pyykkö I, Cremers CW, Kremer H, Dhooge I, Stephens D, Orzan E, Pfister M, Bille M, Parving A, Sorri M, Van de Heyning PH, Makmura L, Ohmen JD, Linthicum FH, Fayad JN, Pearson JV, Craig DW, Stephan DA, Van Camp G. GRM7 variants confer susceptibility to age-related hearing impairment. Hum Mol Genet. 2009 Feb 15; 18(4):785-96. PMID: 19047183.
      View in: PubMed
    37. Niu H, Li X, Makmura L, Friedman RA. Mapping of genetic modifiers of Eya1 ( bor/bor ) in CAST/EiJ and BALB/cJ that suppress cochlear aplasia and associated deafness. Mamm Genome. 2008 Sep; 19(9):634-9. PMID: 18836772.
      View in: PubMed
    38. Slattery WH, Fisher LM, Hitselberger W, Friedman RA, Brackmann DE. Hearing preservation surgery for neurofibromatosis Type 2-related vestibular schwannoma in pediatric patients. J Neurosurg. 2007 Apr; 106(4 Suppl):255-60. PMID: 17465357.
      View in: PubMed
    39. Niu H, Makmura L, Shen T, Sheth SS, Blair K, Friedman RA. Identification of two major loci that suppress hearing loss and cochlear dysmorphogenesis in Eya1bor/bor mice. Genomics. 2006 Sep; 88(3):302-8. PMID: 16488112.
      View in: PubMed
    40. Friedman RA, Brackmann DE, Hitselberger WE, Schwartz MS, Iqbal Z, Berliner KI. Surgical salvage after failed irradiation for vestibular schwannoma. Laryngoscope. 2005 Oct; 115(10):1827-32. PMID: 16222204.
      View in: PubMed
    41. Cunningham CD, Friedman RA, Brackmann DE, Hitselberger WE, Lin HW. Neurotologic skull base surgery in pediatric patients. Otol Neurotol. 2005 Mar; 26(2):231-6. PMID: 15793410.
      View in: PubMed
    42. Friedman RA, Makmura L, Biesiada E, Wang X, Keithley EM. Eya1 acts upstream of Tbx1, Neurogenin 1, NeuroD and the neurotrophins BDNF and NT-3 during inner ear development. Mech Dev. 2005 May; 122(5):625-34. PMID: 15817220.
      View in: PubMed
    43. Shen T, Friedman RA, Brackmann DE, Slattery WH, Hitselberger WE, Schwartz MS, Fisher L. The evolution of surgical approaches for posterior fossa meningiomas. Otol Neurotol. 2004 May; 25(3):394-7. PMID: 15129123.
      View in: PubMed
    44. Friedman RA, Kesser B, Brackmann DE, Fisher LM, Slattery WH, Hitselberger WE. Long-term hearing preservation after middle fossa removal of vestibular schwannoma. Otolaryngol Head Neck Surg. 2003 Dec; 129(6):660-5. PMID: 14663432.
      View in: PubMed
    45. Floyd JA, Gold DA, Concepcion D, Poon TH, Wang X, Keithley E, Chen D, Ward EJ, Chinn SB, Friedman RA, Yu HT, Moriwaki K, Shiroishi T, Hamilton BA. A natural allele of Nxf1 suppresses retrovirus insertional mutations. Nat Genet. 2003 Nov; 35(3):221-8. PMID: 14517553.
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    46. Li XC, Friedman RA. Nonsyndromic hereditary hearing loss. Otolaryngol Clin North Am. 2002 Apr; 35(2):275-85. PMID: 12391618.
      View in: PubMed
    47. Brackmann DE, Owens RM, Friedman RA, Hitselberger WE, De la Cruz A, House JW, Nelson RA, Luxford WM, Slattery WH, Fayad JN. Prognostic factors for hearing preservation in vestibular schwannoma surgery. Am J Otol. 2000 May; 21(3):417-24. PMID: 10821558.
      View in: PubMed
    48. Scott DA, Greinwald JH, Marietta JR, Drury S, Swiderski RE, Viñas A, DeAngelis MM, Carmi R, Ramesh A, Kraft ML, Elbedour K, Skworak AB, Friedman RA, Srikumari Srisailapathy CR, Verhoeven K, Van Gamp G, Lovett M, Deininger PL, Batzer MA, Morton CC, Keats BJ, Smith RJ, Sheffield VC. Identification and mutation analysis of a cochlear-expressed, zinc finger protein gene at the DFNB7/11 and dn hearing-loss loci on human chromosome 9q and mouse chromosome 19. Gene. 1998 Jul 30; 215(2):461-9. PMID: 9758550.
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    49. Pensak ML, Friedman RA. The role of endolymphatic mastoid shunt surgery in the managed care era. Am J Otol. 1998 May; 19(3):337-40. PMID: 9596185.
      View in: PubMed
    50. Pensak ML, Friedman RA. Fallopian bridge technique in surgery for chronic ear disease. Laryngoscope. 1997 Nov; 107(11 Pt 1):1451-6. PMID: 9369389.
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    51. Friedman RA, Pensak ML, Tauber M, Tew JM, van Loveren HR. Anterior petrosectomy approach to infraclinoidal basilar artery aneurysms: the emerging role of the neuro-otologist in multidisciplinary management of basilar artery aneurysms. Laryngoscope. 1997 Jul; 107(7):977-83. PMID: 9217142.
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    52. Friedman RA, Nelson RA, Harris JP. Posterior fossa meningiomas intimately involved with the endolymphatic sac. Am J Otol. 1996 Jul; 17(4):612-6. PMID: 8841708.
      View in: PubMed
    53. Friedman RA, Wood E, Pransky SM, Seid AB, Kearns DB. Nager acrofacial dysostosis: management of a difficult airway. Int J Pediatr Otorhinolaryngol. 1996 Mar; 35(1):69-72. PMID: 8882111.
      View in: PubMed
    54. Friedman RA. Transgenic insertional mutagenesis. Applications to inner-ear genetics. Arch Otolaryngol Head Neck Surg. 1996 Mar; 122(3):252-7. PMID: 8607951.
      View in: PubMed
    55. Friedman RA, Ryan AF. Transgenic mice. Current applications to the study of the auditory and vestibular systems. Otolaryngol Clin North Am. 1992 Oct; 25(5):1017-26. PMID: 1408190.
      View in: PubMed
    56. Friedman RA, Harris JP. Sinusitis. Annu Rev Med. 1991; 42:471-89. PMID: 2035989.
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