Wenxue Ma

Title(s)Project Scientist, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0001-9228-6162 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California-San Diego, San Diego, CAPostdoc04/2005Cancer Immunotherapy
    University of Wisconsin-Madison, Madison, WIPostdoc08/2004Molecular Immunology
    University of Nebraska Medical Center, Omaha, NEPostdoc08/2002Drug Delivery with Nanotechnology
    Zhejiang University, HangzhouPhD06/2002Immuno-Oncology
    Zhejiang Medical University, HangzhouMD07/1989Clinical Medicine
    Zhejiang Medical University, HangzhouMS07/1997Clinical Oncology
    Collapse Awards and Honors
    Frontiers in Immunology2022  - PresAssociate Editor, Cancer Immunity and Immunotherapy
    Cancers2022  - 2023Guest Editor, Cancer Immunology and Immunotherapy
    Huzhou University School of Medicine, China2013  - 2014Dean & Distinguished Professor
    Natural Science Foundation of Zhejiang, China2014  - 2017Identification & application of novel survivin antigenic peptide sequences. PI (LY14H160015)
    Geron Corporation2007  - 2008Induction of telomerase-specific cytotoxic T lymphocytes (Geron/28-1075), PI (WM001)
    American Association for Cancer Research2010  - 2010AACR Scholar-in-Training Award
    International Society for Stem Cell Research2010  - 2010ISSCR Travel Award
    Zhejiang University, China2000  - 2001Outstanding Postgraduate Scholarship
    Zhejiang University, China2000  - 2001Hisun Pharmaceutical Scholarship
    Zhejiang University, China2000  - 2001The First-class Scholarship
    Zhejiang University, China1999  - 2000Tiwu Wang Scholarship

    Collapse Overview 
    Collapse Overview
     Board Certified Surgical Oncologist, MS in Clinical Oncology, PhD in Immuno-Oncology, with specific research interests in cancer immunology and immunotherapy, nanomedicine, cancer/leukemia stem cell.

     Management experience demonstrated with serving as the Dean and a Distinguished Professor, chairing the weekly meeting at Huzhou University. In Vivo Team Lead, and the Director of Drug Discovery in managing 4-12 team members at UC San Diego.

     Scientific leadership demonstrated with the Peer Reviewers of 43 international journals, the EMB of 3 journals, Guest Editor of Cancers (IF 6.639), Associate Editor of Frontiers in Immunology (IF 8.786), Scientific & Medical Advisor at Calidi Biotherapeutics.

     Discovery of Cancer Stem Cell markers in T-cell acute lymphoblastic leukemia and treatment of cancer types driven by Notch1 oncogene (Invention Patent, WO2013044164).

     Identification of two novel HLA-A2 restricted CTL epitopes with stronger immunogenicity than natural survivin (SV95-104) peptide (PMID: 33102521).

     Drug Delivery with Nanotechnology including drugs (paclitaxel, p53 protein, etc.) & tumor antigenic peptides (Mart- 1, gp-100, survivin, telomerase etc.).

     Hands on solid surgical skills demonstrated with Mastectomy/ALN dissection, Thyroidectomy/CLN dissection in clinic; implanting Bioprinted Therapeutic Liver Tissue (BTLT) into the diseased liver in rodents for Organovo Inc.

     20 years of experience with IACUC & IRB standards,SOP, project progress report writing & reviewing on the CIRM (ET II), Pfizer and J&J projects.

     22 years of experience in establishing syngeneic, CDX, PDX models include (1) leukemia (AML, BC/CP CML, T-ALL, MF); (2) solid tumors include melanoma, prostate cancer, breast cancer, metastatic models of TNBC, and brain tumor (via ICV implant); (3) Normal stem cells. Drug delivery routes given including PO, IV, ICV, SC, IM, IP, etc.

     Leading on the CRO projects with our PDX models, which include Pfizer (gamma-secretase inhibitor & Notch 1 mAb) on T-ALL, Oncothyreon (BCL-2 inhibitor) on CML; Jessen R&D (Imetelstat, a telomerase inhibitor) on CML and MF; Celgene (CC6 compound) on AML; Rebecsinib (17S-FD-895) on leukemia & solid tumors/TNBC models.

     Preclinical imaging: Proficient in using the IVIS 200 imaging system to monitor tumor burden in vivo, and skilled in conducting routine H&E, IHC, & IF staining.

     Hobbies: Reading, writing, friend-making, and serving as a sous-chef in the kitchen. 👨‍🍳

    Collapse ORNG Applications 
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. In silico designed mRNA vaccines targeting CA-125 neoantigen in breast and ovarian cancer. Vaccine. 2023 03 17; 41(12):2073-2083. Lu L, Ma W, Johnson CH, Khan SA, Irwin ML, Pusztai L. PMID: 36813666; PMCID: PMC10064809.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Reversal of malignant ADAR1 splice isoform switching with Rebecsinib. Cell Stem Cell. 2023 03 02; 30(3):250-263.e6. Crews LA, Ma W, Ladel L, Pham J, Balaian L, Steel SK, Mondala PK, Diep RH, Wu CN, Mason CN, van der Werf I, Oliver I, Reynoso E, Pineda G, Whisenant TC, Wentworth P, La Clair JJ, Jiang Q, Burkart MD, Jamieson CHM. PMID: 36803553; PMCID: PMC10134781.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    3. Efficacy, Safety, and Challenges of CAR T-Cells in the Treatment of Solid Tumors. Cancers (Basel). 2022 Dec 03; 14(23). Chen Q, Lu L, Ma W. PMID: 36497465.
      View in: PubMed   Mentions: 3  
    4. Breast Cancer Patients: Who Would Benefit from Neoadjuvant Chemotherapies? Curr Oncol. 2022 07 12; 29(7):4902-4913. Yao L, Jia G, Lu L, Ma W. PMID: 35877249; PMCID: PMC9320700.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    5. Immunopathological changes, complications, sequelae and immunological memory in COVID-19 patients. Heliyon. 2022 Apr; 8(4):e09302. Yao L, Lu L, Ma W. PMID: 35497026; PMCID: PMC9040416.
      View in: PubMed   Mentions: 4  
    6. A PSMA-targeted bispecific antibody for prostate cancer driven by a small-molecule targeting ligand. Sci Adv. 2021 08; 7(33). Lee SC, Ma JSY, Kim MS, Laborda E, Choi SH, Hampton EN, Yun H, Nunez V, Muldong MT, Wu CN, Ma W, Kulidjian AA, Kane CJ, Klyushnichenko V, Woods AK, Joseph SB, Petrassi M, Wisler J, Li J, Jamieson CAM, Schultz PG, Kim CH, Young TS. PMID: 34380625; PMCID: PMC8357232.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    7. Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution. Cell Rep. 2021 01 26; 34(4):108670. Jiang Q, Isquith J, Ladel L, Mark A, Holm F, Mason C, He Y, Mondala P, Oliver I, Pham J, Ma W, Reynoso E, Ali S, Morris IJ, Diep R, Nasamran C, Xu G, Sasik R, Rosenthal SB, Birmingham A, Coso S, Pineda G, Crews L, Donohoe ME, Venter JC, Whisenant T, Mesa RA, Alexandrov LB, Fisch KM, Jamieson C. PMID: 33503434; PMCID: PMC8477897.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    8. Novel Survivin Peptides Screened With Computer Algorithm Induce Cytotoxic T Lymphocytes With Higher Cytotoxic Efficiency to Cancer Cells. Front Mol Biosci. 2020; 7:570003. Chen Q, Jia G, Zhao X, Bao Y, Zhang Y, Ozkan C, Minev B, Ma W. PMID: 33102521; PMCID: PMC7496070.
      View in: PubMed   Mentions: 2  
    9. Factors affecting tumor responders and predictive biomarkers of toxicities in cancer patients treated with immune checkpoint inhibitors. Int Immunopharmacol. 2020 Aug; 85:106628. Yao L, Jia G, Lu L, Bao Y, Ma W. PMID: 32474388.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    10. Tumor growth inhibition by mSTEAP peptide nanovaccine inducing augmented CD8+ T cell immune responses. Drug Deliv Transl Res. 2019 12; 9(6):1095-1105. Chen Q, Bao Y, Burner D, Kaushal S, Zhang Y, Mendoza T, Bouvet M, Ozkan C, Minev B, Ma W. PMID: 31228097.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    11. BCMA peptide-engineered nanoparticles enhance induction and function of antigen-specific CD8+ cytotoxic T lymphocytes against multiple myeloma: clinical applications. Leukemia. 2020 01; 34(1):210-223. Bae J, Parayath N, Ma W, Amiji M, Munshi N, Anderson KC. PMID: 31427721; PMCID: PMC7297141.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    12. BRCA1 mRNA expression modifies the effect of T cell activation score on patient survival in breast cancer. BMC Cancer. 2019 Apr 25; 19(1):387. Lu L, Huang H, Zhou J, Ma W, Mackay S, Wang Z. PMID: 31023256; PMCID: PMC6482542.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    13. Hyper-Editing of Cell-Cycle Regulatory and Tumor Suppressor RNA Promotes Malignant Progenitor Propagation. Cancer Cell. 2019 01 14; 35(1):81-94.e7. Jiang Q, Isquith J, Zipeto MA, Diep RH, Pham J, Delos Santos N, Reynoso E, Chau J, Leu H, Lazzari E, Melese E, Ma W, Fang R, Minden M, Morris S, Ren B, Pineda G, Holm F, Jamieson C. PMID: 30612940; PMCID: PMC6333511.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    14. Epithelial membrane protein 2: a novel biomarker for circulating tumor cell recovery in breast cancer. Clin Transl Oncol. 2019 Apr; 21(4):433-442. Chen Q, Yao L, Burner D, Minev B, Lu L, Wang M, Ma W. PMID: 30218306.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    15. Artificial human antigen-presenting cells are superior to dendritic cells at inducing cytotoxic T-cell responses. Immunology. 2017 11; 152(3):462-471. Li H, Shao S, Cai J, Burner D, Lu L, Chen Q, Minev B, Ma W. PMID: 28664991; PMCID: PMC5629434.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    16. Metastasis-Associated Protein 1 Is Involved in Angiogenesis after Transarterial Chemoembolization Treatment. Biomed Res Int. 2017; 2017:6757898. Xue T, Feng W, Yu H, Zhu M, Fei M, Bao Y, Wang X, Ma W, Lv G, Guan J, Chen S. PMID: 28589145; PMCID: PMC5447282.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    17. IFNγ enhances cytotoxic efficiency of the cytotoxic T lymphocytes against human glioma cells. Int Immunopharmacol. 2017 Jun; 47:159-165. Shao S, Risch E, Burner D, Lu L, Minev B, Ma W. PMID: 28410529.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    18. Intracellular Delivery of Molecular Cargo Using Cell-Penetrating Peptides and the Combination Strategies. Int J Mol Sci. 2015 Aug 18; 16(8):19518-36. Li H, Tsui TY, Ma W. PMID: 26295227; PMCID: PMC4581311.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    19. Circulating tumor cell clusters-associated gene plakoglobin and breast cancer survival. Breast Cancer Res Treat. 2015 Jun; 151(3):491-500. Lu L, Zeng H, Gu X, Ma W. PMID: 25957595.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    20. PCSD1, a new patient-derived model of bone metastatic prostate cancer, is castrate-resistant in the bone-niche. J Transl Med. 2014 Oct 03; 12:275. Godebu E, Muldong M, Strasner A, Wu CN, Park SC, Woo JR, Ma W, Liss MA, Hirata T, Raheem O, Cacalano NA, Kulidjian AA, Jamieson CA. PMID: 25278011; PMCID: PMC4192441.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    21. Intracellular delivery of tumor antigenic peptides in biodegradable-polymer adjuvant for enhancing cancer immunotherapy. Curr Med Chem. 2014; 21(21):2357-66. Li H, Ma W. PMID: 25030301.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    22. TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia. Cancer Discov. 2013 May; 3(5):564-77. Sanda T, Tyner JW, Gutierrez A, Ngo VN, Glover J, Chang BH, Yost A, Ma W, Fleischman AG, Zhou W, Yang Y, Kleppe M, Ahn Y, Tatarek J, Kelliher MA, Neuberg DS, Levine RL, Moriggl R, Müller M, Gray NS, Jamieson CH, Weng AP, Staudt LM, Druker BJ, Look AT. PMID: 23471820; PMCID: PMC3651770.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    23. A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. Cell Stem Cell. 2013 Mar 07; 12(3):316-28. Goff DJ, Court Recart A, Sadarangani A, Chun HJ, Barrett CL, Krajewska M, Leu H, Low-Marchelli J, Ma W, Shih AY, Wei J, Zhai D, Geron I, Pu M, Bao L, Chuang R, Balaian L, Gotlib J, Minden M, Martinelli G, Rusert J, Dao KH, Shazand K, Wentworth P, Smith KM, Jamieson CA, Morris SR, Messer K, Goldstein LS, Hudson TJ, Marra M, Frazer KA, Pellecchia M, Reed JC, Jamieson CH. PMID: 23333150; PMCID: PMC3968867.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansCells
    24. Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. Cancer Cell. 2012 Aug 14; 22(2):209-21. Sanda T, Lawton LN, Barrasa MI, Fan ZP, Kohlhammer H, Gutierrez A, Ma W, Tatarek J, Ahn Y, Kelliher MA, Jamieson CH, Staudt LM, Young RA, Look AT. PMID: 22897851; PMCID: PMC3422504.
      View in: PubMed   Mentions: 164     Fields:    Translation:HumansCells
    25. NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. PLoS One. 2012; 7(6):e39725. Ma W, Gutierrez A, Goff DJ, Geron I, Sadarangani A, Jamieson CA, Court AC, Shih AY, Jiang Q, Wu CC, Li K, Smith KM, Crews LA, Gibson NW, Deichaite I, Morris SR, Wei P, Carson DA, Look AT, Jamieson CH. PMID: 22768113; PMCID: PMC3387267.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    26. PLGA nanoparticle-mediated delivery of tumor antigenic peptides elicits effective immune responses. Int J Nanomedicine. 2012; 7:1475-87. Ma W, Chen M, Kaushal S, McElroy M, Zhang Y, Ozkan C, Bouvet M, Kruse C, Grotjahn D, Ichim T, Minev B. PMID: 22619507; PMCID: PMC3356185.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    27. Enhanced presentation of MHC class Ia, Ib and class II-restricted peptides encapsulated in biodegradable nanoparticles: a promising strategy for tumor immunotherapy. J Transl Med. 2011 Mar 31; 9:34. Ma W, Smith T, Bogin V, Zhang Y, Ozkan C, Ozkan M, Hayden M, Schroter S, Carrier E, Messmer D, Kumar V, Minev B. PMID: 21450109; PMCID: PMC3078865.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    28. Nanoparticle-mediated p53 gene therapy for tumor inhibition. Drug Deliv Transl Res. 2011 Feb; 1(1):43-52. Sharma B, Ma W, Adjei IM, Panyam J, Dimitrijevic S, Labhasetwar V. PMID: 22553503; PMCID: PMC3339849.
      View in: PubMed   Mentions: 13     Fields:    
    29. CTLA-4 blockade following relapse of malignancy after allogeneic stem cell transplantation is associated with T cell activation but not with increased levels of T regulatory cells. Biol Blood Marrow Transplant. 2011 May; 17(5):682-92. Zhou J, Bashey A, Zhong R, Corringham S, Messer K, Pu M, Ma W, Chut T, Soiffer R, Mitrovich RC, Lowy I, Ball ED. PMID: 20713164; PMCID: PMC2992836.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCellsCTClinical Trials
    30. Delivery of a peptide via poly(D,L-lactic-co-glycolic) acid nanoparticles enhances its dendritic cell-stimulatory capacity. Nanomedicine. 2010 Oct; 6(5):651-61. Clawson C, Huang CT, Futalan D, Seible DM, Saenz R, Larsson M, Ma W, Minev B, Zhang F, Ozkan M, Ozkan C, Esener S, Messmer D. PMID: 20348031; PMCID: PMC2947606.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    31. Inactivation of LEF1 in T-cell acute lymphoblastic leukemia. Blood. 2010 Apr 08; 115(14):2845-51. Gutierrez A, Sanda T, Ma W, Zhang J, Grebliunaite R, Dahlberg S, Neuberg D, Protopopov A, Winter SS, Larson RS, Borowitz MJ, Silverman LB, Chin L, Hunger SP, Jamieson C, Sallan SE, Look AT. PMID: 20124220; PMCID: PMC2854430.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    32. The prognostic relevance of preoperative transcatheter arterial chemoembolization (TACE) and PCNA/VEGF expression in patients with Wilms' tumour. Eur J Clin Invest. 2008 Dec; 38(12):931-8. Liu WG, Gu WZ, Zhou YB, Tang HF, Li MJ, Ma WX. PMID: 19021718.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    33. Antigenic profiling of glioma cells to generate allogeneic vaccines or dendritic cell-based therapeutics. Clin Cancer Res. 2007 Jan 15; 13(2 Pt 1):566-575. Zhang JG, Eguchi J, Kruse CA, Gomez GG, Fakhrai H, Schroter S, Ma W, Hoa N, Minev B, Delgado C, Wepsic HT, Okada H, Jadus MR. PMID: 17255279; PMCID: PMC4030524.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    34. Dendritic cell activating peptides induce distinct cytokine profiles. Int Immunol. 2006 Nov; 18(11):1563-73. Telusma G, Datta S, Mihajlov I, Ma W, Li J, Yang H, Newman W, Messmer BT, Minev B, Schmidt-Wolf IG, Tracey KJ, Chiorazzi N, Messmer D. PMID: 16966494.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    35. A novel anticancer approach: SEA-anchored tumor cells expressing heat shock protein 70 onto the surface elicit strong anticancer efficacy. Immunol Lett. 2005 Oct 15; 101(1):71-80. Huang C, Yu H, Wang Q, Yang G, Ma W, Xia D, Chen X, Yi P, Shen F, Zheng H, Cao X. PMID: 15908014.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    36. The prognostic value of adhesion molecule CD44v6 in women with primary breast carcinoma: a clinicopathologic study. Clin Oncol (R Coll Radiol). 2005 Jun; 17(4):258-63. Ma W, Deng Y, Zhou L. PMID: 15997921.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    37. Preparation of murine B7.1-glycosylphosphatidylinositol and transmembrane-anchored staphylococcal enterotoxin. A dual-anchored tumor cell vaccine and its antitumor effect. Cancer. 2005 Apr 01; 103(7):1519-28. Yi P, Yu H, Ma W, Wang Q, Minev BR. PMID: 15739200.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    38. Efficacy of transferrin-conjugated paclitaxel-loaded nanoparticles in a murine model of prostate cancer. Int J Cancer. 2004 Nov 01; 112(2):335-40. Sahoo SK, Ma W, Labhasetwar V. PMID: 15352049.
      View in: PubMed   Mentions: 71     Fields:    Translation:Animals
    39. A novel approach for cancer immunotherapy: tumor cells with anchored superantigen SEA generate effective antitumor immunity. J Clin Immunol. 2004 May; 24(3):294-301. Ma W, Yu H, Wang Q, Jin H, Solheim J, Labhasetwar V. PMID: 15114060.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    40. Potent antitumor effect elicited by superantigen-linked tumor cells transduced with heat shock protein 70 gene. Cancer Sci. 2004 Feb; 95(2):160-7. Huang C, Yu H, Wang Q, Ma W, Xia D, Yi P, Zhang L, Cao X. PMID: 14965367.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    41. In vitro biological activities of transmembrane superantigen staphylococcal enterotoxin A fusion protein. Cancer Immunol Immunother. 2004 Feb; 53(2):118-24. Ma W, Yu H, Wang Q, Bao J, Yan J, Jin H. PMID: 14574492.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    42. Polymer degradation and in vitro release of a model protein from poly(D,L-lactide-co-glycolide) nano- and microparticles. J Control Release. 2003 Sep 19; 92(1-2):173-87. Panyam J, Dali MM, Sahoo SK, Ma W, Chakravarthi SS, Amidon GL, Levy RJ, Labhasetwar V. PMID: 14499195.
      View in: PubMed   Mentions: 102     Fields:    Translation:Animals
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