Jorge Gutkind

Title(s)Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-5150-4482 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Buenos Aires, Buenos Aires, ArgentinaPh.D.1985Pharmacology and Biochemistry
    University of Buenos Aires, Buenos Aires, ArgentinaBiochemistry Degree (M.Sc.)1983Biochemistry
    University of Buenos Aires, Buenos Aires, ArgentinaPharmacy Degree (M.Sc.)1980Pharmacology
    Collapse Awards and Honors
    National Academy of Medicine, USA2019Elected, National Academy of Medicine
    Gordon Conference in Molecular Pharmacology, Ventura CA2019Elected Co-Chair, Gordon Conference in Molecular Pharmacology
    American Society for Pharmacology and Experimental Therapeutics (ASPET)2019Elected Chair, Division of Molecular Pharmacology
    International Association of Dental Research (IADR)2017Outstanding Scientist Award
    Pharmaceutical Research and Manufacturers of America (PhRMA)2015Research & Hope Award for “Excellence in Academic Research”
    Annual Meeting and 5th World Congress-IFHNOS2014Elected, Keynote Lecture, 2014 American Head and Neck Society (AHNS)
    Israel Cancer Research Foundation2012Elliot Osserman Award
    Israel Cancer Research Foundation2005Elliot Osserman Award
    NIH2005NIH Director's Award
    International Association of Dental Research (IADR) 2004Distinguished Scientist Award, Oral Medicine and Pathology
    NIDCR, NIH1997NIDR Director’s Exemplary Service Award
    NIH1996NIH Merit Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Multidisciplinary Educational Approach to Reducing Cancer Disparities
    NIH R25CA221779Sep 1, 2019 - Aug 31, 2024
    Role: Principal Investigator
    Stimulating Neo-Antigen Specific T Cell Responses in Head and Neck Cancers
    NIH U01DE028227Sep 19, 2018 - Aug 31, 2023
    Role: Principal Investigator, MPI
    Targeting the EGFR-PI3K/mTOR Signaling Circuitry: A Network-Based Approach for Oral Cancer Precision Therapy
    NIH R01DE026870Aug 1, 2018 - Jul 31, 2023
    Role: Principal Investigator
    Area C: Genome-wide identification and targeting of resistance to cancer therapy
    NIH R33CA225291Sep 30, 2017 - Aug 31, 2020
    Role: Principal Investigator
    Targeting Signaling Vulnerabilities for Oral Cancer Prevention
    NIH R01DE026644Jan 1, 2017 - Dec 31, 2021
    Role: Principal Investigator

    Collapse Featured Content 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dual inhibition of HERs and PD-1 counteract resistance in KRASG12C-mutant head and neck cancer. J Exp Clin Cancer Res. 2024 Nov 20; 43(1):308. Novoplansky O, Jagadeeshan S, Prasad M, Yegodayev KM, Marripati D, Shareb RA, Greenshpan Y, Mathukkada S, Ben-Lulu T, Bhattacharya B, Porgador A, Kong D, Brägelmann J, Gutkind JS, Elkabets M. PMID: 39567998; PMCID: PMC11577641.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Oncogenic H-RAS induces metformin resistance in head and neck cancer by promoting glycolytic metabolism. Cancer Prev Res (Phila). 2024 Oct 28. Wu X, Adame-Garcia SR, Koshizuka K, Vo PTT, Hoang TS, Sato K, Izumi H, Goto Y, Allevato MM, Wood KC, Lippman SM, Gutkind JS. PMID: 39463147.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. YAP-Driven Oral Epithelial Stem Cell Malignant Reprogramming at Single Cell Resolution. bioRxiv. 2024 Oct 21. Faraji F, Ramirez SI, Clubb L, Sato K, Burghi V, Hoang TS, Officer A, Anguiano Quiroz PY, Galloway WM, Mikulski Z, Medetgul-Ernar K, Marangoni P, Jones KB, Molinolo AA, Kim K, Sakaguchi K, Califano JA, Smith Q, Goren A, Klein OD, Tamayo P, Gutkind JS. PMID: 37546810; PMCID: PMC10402053.
      View in: PubMed   Mentions:
    4. Tumor-induced endothelial RhoA activation mediates tumor cell transendothelial migration and metastasis. bioRxiv. 2024 Sep 24. Sajib MS, Zahra FT, Lamprou M, Akwii RG, Park JH, Osorio M, Tullar P, Doci CL, Zhang C, Huveneers S, Van Buul JD, Wang MH, Markiewski MM, Srivastava SK, Zheng Y, Gutkind JS, Hu J, Bickel U, Maeda DY, Zebala JA, Lionakis MS, Trasti S, Mikelis CM. PMID: 39372784; PMCID: PMC11451620.
      View in: PubMed   Mentions:
    5. Targeting G Protein-Coupled Receptors in Immuno-Oncological Therapies. Annu Rev Pharmacol Toxicol. 2024 Sep 13. Stagg J, Gutkind JS. PMID: 39270681.
      View in: PubMed   Mentions:    Fields:    
    6. Linoleoyl-lysophosphatidylcholine suppresses immune-related adverse events due to immune checkpoint blockade. medRxiv. 2024 Aug 08. Mathews IT, Saminathan P, Henglin M, Liu M, Nadig N, Fang C, Mercader K, Chee SJ, Campbell AM, Patel AA, Tiwari S, Watrous JD, Ramesh K, Dicker M, Dao K, Meyer MA, Jousilahti P, Havulinna AS, Niiranen T, Salomaa V, Joosten LAB, Netea MG, Zheng P, Kronenberg M, Patel SP, Gutkind JS, Ottensmeier C, Long T, Kaech SM, Hedrick CC, Cheng S, Jain M, Sharma S. PMID: 39148854; PMCID: PMC11326322.
      View in: PubMed   Mentions:
    7. Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation. NPJ Syst Biol Appl. 2024 Jul 16; 10(1):75. Trogdon M, Abbott K, Arang N, Lande K, Kaur N, Tong M, Bakhoum M, Gutkind JS, Stites EC. PMID: 39013872; PMCID: PMC11252164.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. A genome-wide CRISPR screen reveals that antagonism of glutamine metabolism sensitizes head and neck squamous cell carcinoma to ferroptotic cell death. Cancer Lett. 2024 Aug 28; 598:217089. Allevato MM, Trinh S, Koshizuka K, Nachmanson D, Nguyen TC, Yokoyama Y, Wu X, Andres A, Wang Z, Watrous J, Molinolo AA, Mali P, Harismendy O, Jain M, Wild R, Gutkind JS. PMID: 38964731.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. Pan-RAF:MEK Molecular Glues Take Center Stage. Cancer Discov. 2024 Jul 01; 14(7):1143-1144. Hangauer MJ, Gutkind JS, Ferguson FM. PMID: 38946324.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC. Cancer Res Commun. 2024 Jul 01; 4(7):1850-1862. Goto Y, Koshizuka K, Ando T, Izumi H, Wu X, Sato K, Ishikawa T, Ford K, Feng X, Wang Z, Arang N, Allevato MM, Kishore A, Mali P, Gutkind JS. PMID: 38954773; PMCID: PMC11284272.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. Let it be: Preserving tumor-draining lymph nodes in the era of immuno-oncology. Cancer Cell. 2024 Jun 10; 42(6):930-933. Saddawi-Konefka R, Schokrpur S, Gutkind JS. PMID: 38861928.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    12. Mouse Models for Head and Neck Squamous Cell Carcinoma. J Dent Res. 2024 06; 103(6):585-595. Zhou J, Liu C, Amornphimoltham P, Cheong SC, Gutkind JS, Chen Q, Wang Z. PMID: 38722077.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    13. The landscape of cancer-rewired GPCR signaling axes. Cell Genom. 2024 May 08; 4(5):100557. Arora C, Matic M, Bisceglia L, Di Chiaro P, De Oliveira Rosa N, Carli F, Clubb L, Nemati Fard LA, Kargas G, Diaferia GR, Vukotic R, Licata L, Wu G, Natoli G, Gutkind JS, Raimondi F. PMID: 38723607; PMCID: PMC11099383.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    14. CHMP2A regulates broad immune cell-mediated antitumor activity in an immunocompetent in vivo head and neck squamous cell carcinoma model. J Immunother Cancer. 2024 May 03; 12(5). Yun J, Saddawi-Konefka R, Goldenson B, Al-Msari R, Bernareggi D, Thangaraj JL, Tang S, Patel SH, Luna SM, Gutkind JS, Kaufman D. PMID: 38702144; PMCID: PMC11086353.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    15. Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer. Nat Commun. 2024 May 03; 15(1):3741. Haderk F, Chou YT, Cech L, Fernández-Méndez C, Yu J, Olivas V, Meraz IM, Barbosa Rabago D, Kerr DL, Gomez C, Allegakoen DV, Guan J, Shah KN, Herrington KA, Gbenedio OM, Nanjo S, Majidi M, Tamaki W, Pourmoghadam YK, Rotow JK, McCoach CE, Riess JW, Gutkind JS, Tang TT, Post L, Huang B, Santisteban P, Goodarzi H, Bandyopadhyay S, Kuo CJ, Roose JP, Wu W, Blakely CM, Roth JA, Bivona TG. PMID: 38702301; PMCID: PMC11068778.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    16. Many paths lead to immunology. Cell. 2024 Apr 25; 187(9):2117-2119. García-Sáez AJ, Domingos AI, Gutkind JS, Mattoo S, Du P. PMID: 38670068.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    17. Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4. bioRxiv. 2024 Apr 17. Ravala SK, Adame-Garcia SR, Li S, Chen CL, Cianfrocco MA, Gutkind JS, Cash JN, Tesmer JJG. PMID: 37745379; PMCID: PMC10515948.
      View in: PubMed   Mentions:
    18. Gα12 signaling regulates transcriptional and phenotypic responses that promote glioblastoma tumor invasion. Sci Rep. 2023 12 16; 13(1):22412. Chaim OM, Miki S, Prager BC, Ma J, Jeong AY, Lara J, Tran NK, Smith JM, Rich JN, Gutkind JS, Miyamoto S, Furnari FB, Brown JH. PMID: 38104152; PMCID: PMC10725435.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    19. Akt Is Controlled by Bag5 through a Monoubiquitination to Polyubiquitination Switch. Int J Mol Sci. 2023 Dec 15; 24(24). Bracho-Valdés I, Cervantes-Villagrana RD, Beltrán-Navarro YM, Olguín-Olguín A, Escobar-Islas E, Carretero-Ortega J, Olivares-Reyes JA, Reyes-Cruz G, Gutkind JS, Vázquez-Prado J. PMID: 38139359; PMCID: PMC10743781.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    20. Kinome profiling identifies MARK3 and STK10 as potential therapeutic targets in uveal melanoma. J Biol Chem. 2023 Dec; 299(12):105418. Baqai U, Kurimchak AM, Trachtenberg IV, Purwin TJ, Haj JI, Han A, Luo K, Pachon NF, Jeon A, Chua V, Davies MA, Gutkind JS, Benovic JL, Duncan JS, Aplin AE. PMID: 37923138; PMCID: PMC10716579.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    21. YAP-Driven Malignant Reprogramming of Epithelial Stem Cells at Single Cell Resolution. Res Sq. 2023 Oct 27. Gutkind JS, Faraji F, Ramirez S, Clubb L, Sato K, Quiroz PA, Galloway W, Mikulski Z, Hoang T, Medetgul-Ernar K, Marangoni P, Jones K, Officer A, Molinolo A, Kim K, Sakaguchi K, Califano J, Smith Q, Klein O, Tamayo P. PMID: 37961717; PMCID: PMC10635308.
      View in: PubMed   Mentions:
    22. High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma. Cell Rep Med. 2023 11 21; 4(11):101244. Arang N, Lubrano S, Ceribelli M, Rigiracciolo DC, Saddawi-Konefka R, Faraji F, Ramirez SI, Kim D, Tosto FA, Stevenson E, Zhou Y, Wang Z, Bogomolovas J, Molinolo AA, Swaney DL, Krogan NJ, Yang J, Coma S, Pachter JA, Aplin AE, Alessi DR, Thomas CJ, Gutkind JS. PMID: 37858338; PMCID: PMC10694608.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    23. The landscape of cancer rewired GPCR signaling axes. bioRxiv. 2023 Oct 11. Arora C, Matic M, DiChiaro P, Rosa NO, Carli F, Clubb L, Fard LAN, Kargas G, Diaferia G, Vukotic R, Licata L, Wu G, Natoli G, Gutkind JS, Raimondi F. PMID: 37398064; PMCID: PMC10312480.
      View in: PubMed   Mentions:
    24. Pan-Cancer Analysis of Patient Tumor Single-Cell Transcriptomes Identifies Promising Selective and Safe Chimeric Antigen Receptor Targets in Head and Neck Cancer. Cancers (Basel). 2023 Oct 08; 15(19). Madan S, Sinha S, Chang T, Gutkind JS, Cohen EEW, Schäffer AA, Ruppin E. PMID: 37835579; PMCID: PMC10571718.
      View in: PubMed   Mentions:
    25. Tipifarnib Potentiates the Antitumor Effects of PI3Kα Inhibition in PIK3CA- and HRAS-Dysregulated HNSCC via Convergent Inhibition of mTOR Activity. Cancer Res. 2023 10 02; 83(19):3252-3263. Smith AE, Chan S, Wang Z, McCloskey A, Reilly Q, Wang JZ, Patel HV, Koshizuka K, Soifer HS, Kessler L, Dayoub A, Villaflor V, Adkins DR, Bruce JY, Ho AL, Perez CA, Hanna GJ, Gascó Hernández A, Saunders A, Dale S, Gutkind JS, Burrows F, Malik S. PMID: 37339176; PMCID: PMC10543974.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    26. Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor. J Biol Chem. 2023 11; 299(11):105293. Burghi V, Paradis JS, Officer A, Adame-Garcia SR, Wu X, Matthees ESF, Barsi-Rhyne B, Ramms DJ, Clubb L, Acosta M, Tamayo P, Bouvier M, Inoue A, von Zastrow M, Hoffmann C, Gutkind JS. PMID: 37774973; PMCID: PMC10641165.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    27. A Network Landscape of HPVOPC Reveals Methylation Alterations as Significant Drivers of Gene Expression via an Immune-Mediated GPCR Signal. Cancers (Basel). 2023 Sep 01; 15(17). Qualliotine JR, Nakagawa T, Rosenthal SB, Sadat S, Ballesteros-Merino C, Xu G, Mark A, Nasamran A, Gutkind JS, Fisch KM, Guo T, Fox BA, Khan Z, Molinolo AA, Califano JA. PMID: 37686653; PMCID: PMC10486378.
      View in: PubMed   Mentions:
    28. AXL activates YAP through the EGFR-LATS1/2 axis and confers resistance to EGFR-targeted drugs in head and neck squamous cell carcinoma. Oncogene. 2023 09; 42(39):2869-2877. Okamoto K, Ando T, Izumi H, Kobayashi SS, Shintani T, Gutkind JS, Yanamoto S, Miyauchi M, Kajiya M. PMID: 37591955.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    29. The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure. Nat Immunol. 2023 08; 24(8):1318-1330. Wu VH, Yung BS, Faraji F, Saddawi-Konefka R, Wang Z, Wenzel AT, Song MJ, Pagadala MS, Clubb LM, Chiou J, Sinha S, Matic M, Raimondi F, Hoang TS, Berdeaux R, Vignali DAA, Iglesias-Bartolome R, Carter H, Ruppin E, Mesirov JP, Gutkind JS. PMID: 37308665; PMCID: PMC10735169.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    30. Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response. Nat Commun. 2023 05 12; 14(1):2744. Pagadala M, Sears TJ, Wu VH, Pérez-Guijarro E, Kim H, Castro A, Talwar JV, Gonzalez-Colin C, Cao S, Schmiedel BJ, Goudarzi S, Kirani D, Au J, Zhang T, Landi T, Salem RM, Morris GP, Harismendy O, Patel SP, Alexandrov LB, Mesirov JP, Zanetti M, Day CP, Fan CC, Thompson WK, Merlino G, Gutkind JS, Vijayanand P, Carter H. PMID: 37173324; PMCID: PMC10182072.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    31. Mutated HRAS Activates YAP1-AXL Signaling to Drive Metastasis of Head and Neck Cancer. Cancer Res. 2023 04 04; 83(7):1031-1047. Jagadeeshan S, Prasad M, Badarni M, Ben-Lulu T, Liju VB, Mathukkada S, Saunders C, Shnerb AB, Zorea J, Yegodayev KM, Wainer M, Vtorov L, Allon I, Cohen O, Gausdal G, Friedmann-Morvinski D, Cheong SC, Ho AL, Rosenberg AJ, Kessler L, Burrows F, Kong D, Grandis JR, Gutkind JS, Elkabets M. PMID: 36753744; PMCID: PMC10073343.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    32. CTLA-4 blockade induces tumor pyroptosis via CD8+ T cells in head and neck squamous cell carcinoma. Mol Ther. 2023 07 05; 31(7):2154-2168. Wang S, Wu ZZ, Zhu SW, Wan SC, Zhang MJ, Zhang BX, Yang QC, Xiao Y, Li H, Mao L, Wang ZY, Gutkind JS, Sun ZJ. PMID: 36869589; PMCID: PMC10362385.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    33. Catalytic site mutations confer multiple states of G protein activation. Sci Signal. 2023 02 14; 16(772):eabq7842. Hewitt N, Ma N, Arang N, Martin SA, Prakash A, DiBerto JF, Knight KM, Ghosh S, Olsen RHJ, Roth BL, Gutkind JS, Vaidehi N, Campbell SL, Dohlman HG. PMID: 36787384; PMCID: PMC10021883.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    34. A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAFV600E colorectal tumors. Nat Cancer. 2023 02; 4(2):240-256. Ruiz-Saenz A, Atreya CE, Wang C, Pan B, Dreyer CA, Brunen D, Prahallad A, Muñoz DP, Ramms DJ, Burghi V, Spassov DS, Fewings E, Hwang YC, Cowdrey C, Moelders C, Schwarzer C, Wolf DM, Hann B, VandenBerg SR, Shokat K, Moasser MM, Bernards R, Gutkind JS, van 't Veer LJ, Coppé JP. PMID: 36759733; PMCID: PMC9970872.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    35. Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ-focal adhesion kinase signaling circuitry. J Biol Chem. 2023 02; 299(2):102866. Arang N, Lubrano S, Rigiracciolo DC, Nachmanson D, Lippman SM, Mali P, Harismendy O, Gutkind JS. PMID: 36596361; PMCID: PMC9922814.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    36. A Randomized Multi-institutional Phase II Trial of Everolimus as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck. Clin Cancer Res. 2022 12 01; 28(23):5040-5048. Nathan CO, Hayes DN, Karrison T, Harismendy O, Flores JM, Moore-Medlin T, Vokes EE, Gutkind JS, Neupane P, Mills G, Sargi Z, Seiwert T, Grilley-Olson J, Day T, Gillison M, Wade JL, Feldman L, Jha G, Kozloff M, O'Leary M, Worden FP, Cohen EEW. PMID: 36194164; PMCID: PMC9722644.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCellsCTClinical Trials
    37. Somatic 9p24.1 alterations in HPV- head and neck squamous cancer dictate immune microenvironment and anti-PD-1 checkpoint inhibitor activity. Proc Natl Acad Sci U S A. 2022 11 22; 119(47):e2213835119. Zhao X, Cohen EEW, William WN, Bianchi JJ, Abraham JP, Magee D, Spetzler DB, Gutkind JS, Alexandrov LB, Cavenee WK, Lippman SM, Davoli T. PMID: 36395141; PMCID: PMC9704728.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    38. Challenges and Emerging Opportunities for Targeting mTOR in Cancer. Cancer Res. 2022 11 02; 82(21):3884-3887. Wood KC, Gutkind JS. PMID: 36321262; PMCID: PMC9634680.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    39. Integrating Genetic Alterations and the Hippo Pathway in Head and Neck Squamous Cell Carcinoma for Future Precision Medicine. J Pers Med. 2022 Sep 20; 12(10). Ando T, Okamoto K, Shintani T, Yanamoto S, Miyauchi M, Gutkind JS, Kajiya M. PMID: 36294681; PMCID: PMC9604790.
      View in: PubMed   Mentions: 4  
    40. HER2 and HER3 as Therapeutic Targets in Head and Neck Cancer. Cancer J. 2022 Sep-Oct 01; 28(5):339-345. Saddawi-Konefka R, Schokrpur S, Lui AJ, Gutkind JS. PMID: 36165721; PMCID: PMC9523502.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    41. Lymphatic-preserving treatment sequencing with immune checkpoint inhibition unleashes cDC1-dependent antitumor immunity in HNSCC. Nat Commun. 2022 07 25; 13(1):4298. Saddawi-Konefka R, O'Farrell A, Faraji F, Clubb L, Allevato MM, Jensen SM, Yung BS, Wang Z, Wu VH, Anang NA, Msari RA, Schokrpur S, Pietryga IF, Molinolo AA, Mesirov JP, Simon AB, Fox BA, Bui JD, Sharabi A, Cohen EEW, Califano JA, Gutkind JS. PMID: 35879302; PMCID: PMC9314425.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    42. PRECOGx: exploring GPCR signaling mechanisms with deep protein representations. Nucleic Acids Res. 2022 07 05; 50(W1):W598-W610. Matic M, Singh G, Carli F, De Oliveira Rosa N, Miglionico P, Magni L, Gutkind JS, Russell RB, Inoue A, Raimondi F. PMID: 35639758; PMCID: PMC9252787.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    43. Monomethyl auristatin antibody and peptide drug conjugates for trimodal cancer chemo-radio-immunotherapy. Nat Commun. 2022 07 05; 13(1):3869. Hingorani DV, Allevato MM, Camargo MF, Lesperance J, Quraishi MA, Aguilera J, Franiak-Pietryga I, Scanderbeg DJ, Wang Z, Molinolo AA, Alvarado D, Sharabi AB, Bui JD, Cohen EEW, Adams SR, Gutkind JS, Advani SJ. PMID: 35790753; PMCID: PMC9256669.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    44. Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1. J Biol Chem. 2022 08; 298(8):102209. Bandekar SJ, Chen CL, Ravala SK, Cash JN, Avramova LV, Zhalnina MV, Gutkind JS, Li S, Tesmer JJG. PMID: 35779635; PMCID: PMC9372627.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    45. Focal Adhesion Kinase (FAK)-Hippo/YAP transduction signaling mediates the stimulatory effects exerted by S100A8/A9-RAGE system in triple-negative breast cancer (TNBC). J Exp Clin Cancer Res. 2022 Jun 03; 41(1):193. Rigiracciolo DC, Nohata N, Lappano R, Cirillo F, Talia M, Adame-Garcia SR, Arang N, Lubrano S, De Francesco EM, Belfiore A, Gutkind JS, Maggiolini M. PMID: 35655319; PMCID: PMC9164429.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    46. Genomic Hippo Pathway Alterations and Persistent YAP/TAZ Activation: New Hallmarks in Head and Neck Cancer. Cells. 2022 04 18; 11(8). Faraji F, Ramirez SI, Anguiano Quiroz PY, Mendez-Molina AN, Gutkind JS. PMID: 35456049; PMCID: PMC9028246.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    47. Microneedle-mediated Intratumoral Delivery of Anti-CTLA-4 Promotes cDC1-dependent Eradication of Oral Squamous Cell Carcinoma with Limited irAEs. Mol Cancer Ther. 2022 04 01; 21(4):616-624. Gilardi M, Saddawi-Konefka R, Wu VH, Lopez-Ramirez MA, Wang Z, Soto F, Ramms DJ, Proietto M, Mikulski Z, Miki H, Sharabi A, Kupor D, Rueda R, Hollern DP, Wang J, Gutkind JS. PMID: 35086958; PMCID: PMC8983493.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    48. Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER+ breast cancer. Nat Commun. 2022 02 25; 13(1):1061. Ma S, Tang T, Probst G, Konradi A, Jin C, Li F, Gutkind JS, Fu XD, Guan KL. PMID: 35217640; PMCID: PMC8881512.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    49. EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1. Commun Biol. 2021 11 01; 4(1):1237. Ando T, Arang N, Wang Z, Costea DE, Feng X, Goto Y, Izumi H, Gilardi M, Ando K, Gutkind JS. PMID: 34725466; PMCID: PMC8560880.
      View in: PubMed   Mentions: 20  Translation:AnimalsCells
    50. A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity. Science. 2021 Oct; 374(6563):eabf2911. Swaney DL, Ramms DJ, Wang Z, Park J, Goto Y, Soucheray M, Bhola N, Kim K, Zheng F, Zeng Y, McGregor M, Herrington KA, O'Keefe R, Jin N, VanLandingham NK, Foussard H, Von Dollen J, Bouhaddou M, Jimenez-Morales D, Obernier K, Kreisberg JF, Kim M, Johnson DE, Jura N, Grandis JR, Gutkind JS, Ideker T, Krogan NJ. PMID: 34591642; PMCID: PMC9005332.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    51. Interpretation of cancer mutations using a multiscale map of protein systems. Science. 2021 Oct; 374(6563):eabf3067. Zheng F, Kelly MR, Ramms DJ, Heintschel ML, Tao K, Tutuncuoglu B, Lee JJ, Ono K, Foussard H, Chen M, Herrington KA, Silva E, Liu SN, Chen J, Churas C, Wilson N, Kratz A, Pillich RT, Patel DN, Park J, Kuenzi B, Yu MK, Licon K, Pratt D, Kreisberg JF, Kim M, Swaney DL, Nan X, Fraley SI, Gutkind JS, Krogan NJ, Ideker T. PMID: 34591613; PMCID: PMC9126298.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    52. Gαs-Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant Gαs-PKA Signaling. Pharmacol Rev. 2021 10; 73(4):155-197. Ramms DJ, Raimondi F, Arang N, Herberg FW, Taylor SS, Gutkind JS. PMID: 34663687; PMCID: PMC11060502.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    53. Inhibition of mTOR signaling and clinical activity of metformin in oral premalignant lesions. JCI Insight. 2021 09 08; 6(17). Gutkind JS, Molinolo AA, Wu X, Wang Z, Nachmanson D, Harismendy O, Alexandrov LB, Wuertz BR, Ondrey FG, Laronde D, Rock LD, Rosin M, Coffey C, Butler VD, Bengtson L, Hsu CH, Bauman JE, Hewitt SM, Cohen EE, Chow HS, Lippman SM, Szabo E. PMID: 34255745; PMCID: PMC8492350.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCellsCTClinical Trials
    54. Correction: Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma. Clin Cancer Res. 2021 Aug 15; 27(16):4664. Paradis JS, Acosta M, Saddawi-Konefka R, Kishore A, Lubrano S, Gomes F, Arang N, Tiago M, Coma S, Wu X, Ford K, Day CP, Merlino G, Mali P, Pachter JA, Sato T, Aplin AE, Gutkind JS. PMID: 34389658.
      View in: PubMed   Mentions: 1     Fields:    
    55. Calcium signaling induces a partial EMT. EMBO Rep. 2021 09 06; 22(9):e51872. Norgard RJ, Pitarresi JR, Maddipati R, Aiello-Couzo NM, Balli D, Li J, Yamazoe T, Wengyn MD, Millstein ID, Folkert IW, Rosario-Berrios DN, Kim IK, Bassett JB, Payne R, Berry CT, Feng X, Sun K, Cioffi M, Chakraborty P, Jolly MK, Gutkind JS, Lyden D, Freedman BD, Foskett JK, Rustgi AK, Stanger BZ. PMID: 34324787; PMCID: PMC8419705.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    56. Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer. Nat Commun. 2021 04 22; 12(1):2383. Wang Z, Goto Y, Allevato MM, Wu VH, Saddawi-Konefka R, Gilardi M, Alvarado D, Yung BS, O'Farrell A, Molinolo AA, Duvvuri U, Grandis JR, Califano JA, Cohen EEW, Gutkind JS. PMID: 33888713; PMCID: PMC8062674.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    57. Cancer-associated fibroblast secretion of PDGFC promotes gastrointestinal stromal tumor growth and metastasis. Oncogene. 2021 03; 40(11):1957-1973. Yoon H, Tang CM, Banerjee S, Yebra M, Noh S, Burgoyne AM, Torre J, Siena M, Liu M, Klug LR, Choi YY, Hosseini M, Delgado AL, Wang Z, French RP, Lowy A, DeMatteo RP, Heinrich MC, Molinolo AA, Gutkind JS, Harismendy O, Sicklick JK. PMID: 33603171; PMCID: PMC7979540.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    58. Insights into epithelial cell senescence from transcriptome and secretome analysis of human oral keratinocytes. Aging (Albany NY). 2021 02 12; 13(4):4747-4777. Schwartz RE, Shokhirev MN, Andrade LR, Gutkind JS, Iglesias-Bartolome R, Shadel GS. PMID: 33601339; PMCID: PMC7950289.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    59. Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma. Clin Cancer Res. 2021 06 01; 27(11):3190-3200. Paradis JS, Acosta M, Saddawi-Konefka R, Kishore A, Gomes F, Arang N, Tiago M, Coma S, Lubrano S, Wu X, Ford K, Day CP, Merlino G, Mali P, Pachter JA, Sato T, Aplin AE, Gutkind JS. PMID: 33568347; PMCID: PMC8895627.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    60. Focal Adhesion Kinase Fine Tunes Multifaced Signals toward Breast Cancer Progression. Cancers (Basel). 2021 Feb 05; 13(4). Rigiracciolo DC, Cirillo F, Talia M, Muglia L, Gutkind JS, Maggiolini M, Lappano R. PMID: 33562737; PMCID: PMC7915897.
      View in: PubMed   Mentions: 26  
    61. The anti-tumour activity of DNA methylation inhibitor 5-aza-2'-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress. Cancer Lett. 2021 03 31; 501:172-186. Gleneadie HJ, Baker AH, Batis N, Bryant J, Jiang Y, Clokie SJH, Mehanna H, Garcia P, Gendoo DMA, Roberts S, Burley M, Molinolo AA, Gutkind JS, Scheven BA, Cooper PR, Parish JL, Khanim FL, Wiench M. PMID: 33359448; PMCID: PMC7845757.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    62. Correction: Rigiracciolo, D.C., et al., IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth Effects in Triple-Negative Breast Cancer (TNBC) Cells. Cells 2020, 9, 1010. Cells. 2020 Dec 06; 9(12). Rigiracciolo DC, Nohata N, Lappano R, Cirillo F, Talia M, Scordamaglia D, Gutkind JS, Maggiolini M. PMID: 33291355; PMCID: PMC7762122.
      View in: PubMed   Mentions: 2     Fields:    
    63. G Protein-Coupled receptors and heterotrimeric G proteins as cancer drivers. FEBS Lett. 2020 12; 594(24):4201-4232. Arang N, Gutkind JS. PMID: 33270228; PMCID: PMC8849590.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    64. Detecting cancer metastasis and accompanying protein biomarkers at single cell levels using a 3D-printed microfluidic immunoarray. Biosens Bioelectron. 2021 Jan 01; 171:112681. Sharafeldin M, Chen T, Ozkaya GU, Choudhary D, Molinolo AA, Gutkind JS, Rusling JF. PMID: 33096435; PMCID: PMC7666000.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    65. Gαs directly drives PDZ-RhoGEF signaling to Cdc42. J Biol Chem. 2020 12 11; 295(50):16920-16928. Castillo-Kauil A, García-Jiménez I, Cervantes-Villagrana RD, Adame-García SR, Beltrán-Navarro YM, Gutkind JS, Reyes-Cruz G, Vázquez-Prado J. PMID: 33023908; PMCID: PMC7863908.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    66. HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers. Oncogene. 2020 10; 39(40):6327-6339. Ren S, Gaykalova DA, Guo T, Favorov AV, Fertig EJ, Tamayo P, Callejas-Valera JL, Allevato M, Gilardi M, Santos J, Fukusumi T, Sakai A, Ando M, Sadat S, Liu C, Xu G, Fisch KM, Wang Z, Molinolo AA, Gutkind JS, Ideker T, Koch WM, Califano JA. PMID: 32848210; PMCID: PMC7529583.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    67. Unleashing Immunotherapy by Targeting Cancer Stem Cells. Cell Stem Cell. 2020 08 06; 27(2):187-189. Iglesias-Bartolome R, Gutkind JS. PMID: 32763176; PMCID: PMC10249586.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    68. Tipifarnib as a Precision Therapy for HRAS-Mutant Head and Neck Squamous Cell Carcinomas. Mol Cancer Ther. 2020 09; 19(9):1784-1796. Gilardi M, Wang Z, Proietto M, Chillà A, Calleja-Valera JL, Goto Y, Vanoni M, Janes MR, Mikulski Z, Gualberto A, Molinolo AA, Ferrara N, Gutkind JS, Burrows F. PMID: 32727882; PMCID: PMC7484242.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    69. Nonmuscle myosin 2 regulates cortical stability during sprouting angiogenesis. Mol Biol Cell. 2020 08 15; 31(18):1974-1987. Ma X, Uchida Y, Wei T, Liu C, Adams RH, Kubota Y, Gutkind JS, Mukouyama YS, Adelstein RS. PMID: 32583739; PMCID: PMC7543065.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    70. G protein-regulated endocytic trafficking of adenylyl cyclase type 9. Elife. 2020 06 09; 9. Lazar AM, Irannejad R, Baldwin TA, Sundaram AB, Gutkind JS, Inoue A, Dessauer CW, Von Zastrow M. PMID: 32515353; PMCID: PMC7332294.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    71. Aberrant expression of CPSF1 promotes head and neck squamous cell carcinoma via regulating alternative splicing. PLoS One. 2020; 15(5):e0233380. Sakai A, Ando M, Fukusumi T, Ren S, Liu C, Qualliotine J, Haft S, Sadat S, Saito Y, Guo TW, Xu G, Sasik R, Fisch KM, Gutkind JS, Fertig EJ, Molinolo AA, Califano JA. PMID: 32437477; PMCID: PMC7241804.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    72. Development and optimization of orthotopic liver metastasis xenograft mouse models in uveal melanoma. J Transl Med. 2020 05 20; 18(1):208. Sugase T, Lam BQ, Danielson M, Terai M, Aplin AE, Gutkind JS, Sato T. PMID: 32434572; PMCID: PMC7240939.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    73. Pathway-Specific Genome Editing of PI3K/mTOR Tumor Suppressor Genes Reveals that PTEN Loss Contributes to Cetuximab Resistance in Head and Neck Cancer. Mol Cancer Ther. 2020 07; 19(7):1562-1571. Izumi H, Wang Z, Goto Y, Ando T, Wu X, Zhang X, Li H, Johnson DE, Grandis JR, Gutkind JS. PMID: 32430488; PMCID: PMC7357849.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    74. IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth Effects in Triple-Negative Breast Cancer (TNBC) Cells. Cells. 2020 04 18; 9(4). Rigiracciolo DC, Nohata N, Lappano R, Cirillo F, Talia M, Scordamaglia D, Gutkind JS, Maggiolini M. PMID: 32325700; PMCID: PMC7225986.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    75. Redirecting extracellular proteases to molecularly guide radiosensitizing drugs to tumors. Biomaterials. 2020 07; 248:120032. Hingorani DV, Crisp JL, Doan MK, Camargo MF, Quraishi MA, Aguilera J, Gilardi M, Gross LA, Jiang T, Li WT, Ongkeko WM, Cohen EEW, Gutkind JS, Adams SR, Advani SJ. PMID: 32304937; PMCID: PMC7285923.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    76. Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK-YAP signaling axis. Oncogene. 2020 05; 39(20):4014-4027. Goto Y, Ando T, Izumi H, Feng X, Arang N, Gilardi M, Wang Z, Ando K, Gutkind JS. PMID: 32205868; PMCID: PMC7428076.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    77. B Cells Improve Overall Survival in HPV-Associated Squamous Cell Carcinomas and Are Activated by Radiation and PD-1 Blockade. Clin Cancer Res. 2020 07 01; 26(13):3345-3359. Kim SS, Shen S, Miyauchi S, Sanders PD, Franiak-Pietryga I, Mell L, Gutkind JS, Cohen EEW, Califano JA, Sharabi AB. PMID: 32193227; PMCID: PMC7334097.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    78. mTOR inhibitor use in head and neck squamous cell carcinoma: A meta-analysis on survival, tumor response, and toxicity. Laryngoscope Investig Otolaryngol. 2020 Apr; 5(2):243-255. Patel J, Nguyen SA, Ogretmen B, Gutkind JS, Nathan CA, Day T. PMID: 32337356; PMCID: PMC7178455.
      View in: PubMed   Mentions: 13  
    79. Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling. Nat Commun. 2020 03 05; 11(1):1204. Stratman AN, Farrelly OM, Mikelis CM, Miller MF, Wang Z, Pham VN, Davis AE, Burns MC, Pezoa SA, Castranova D, Yano JJ, Kilts TM, Davis GE, Gutkind JS, Weinstein BM. PMID: 32139674; PMCID: PMC7058007.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    80. Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation. Clin Cancer Res. 2020 06 01; 26(11):2693-2703. Liu C, Sadat SH, Ebisumoto K, Sakai A, Panuganti BA, Ren S, Goto Y, Haft S, Fukusumi T, Ando M, Saito Y, Guo T, Tamayo P, Yeerna H, Kim W, Hubbard J, Sharabi AB, Gutkind JS, Califano JA. PMID: 31932491; PMCID: PMC7538010.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    81. HPV16 E5 Mediates Resistance to PD-L1 Blockade and Can Be Targeted with Rimantadine in Head and Neck Cancer. Cancer Res. 2020 02 15; 80(4):732-746. Miyauchi S, Sanders PD, Guram K, Kim SS, Paolini F, Venuti A, Cohen EEW, Gutkind JS, Califano JA, Sharabi AB. PMID: 31848196; PMCID: PMC7024675.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    82. Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4. Nat Commun. 2019 12 05; 10(1):5546. Wang Z, Wu VH, Allevato MM, Gilardi M, He Y, Luis Callejas-Valera J, Vitale-Cross L, Martin D, Amornphimoltham P, Mcdermott J, Yung BS, Goto Y, Molinolo AA, Sharabi AB, Cohen EEW, Chen Q, Lyons JG, Alexandrov LB, Gutkind JS. PMID: 31804466; PMCID: PMC6895221.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    83. Activation of G-Protein Coupled Receptor-Gαi Signaling Increases Keratinocyte Proliferation and Reduces Differentiation, Leading to Epidermal Hyperplasia. J Invest Dermatol. 2020 06; 140(6):1195-1203.e3. Pedro MP, Salinas Parra N, Gutkind JS, Iglesias-Bartolome R. PMID: 31707029; PMCID: PMC7202966.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    84. Metformin Is Associated With Reduced Odds for Colorectal Cancer Among Persons With Diabetes. Clin Transl Gastroenterol. 2019 11; 10(11):e00092. Demb J, Yaseyyedi A, Liu L, Bustamante R, Earles A, Ghosh P, Gutkind JS, Gawron AJ, Kaltenbach TR, Martinez ME, Gupta S. PMID: 31770138; PMCID: PMC6890275.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    85. Targeting mTOR in Head and Neck Cancer-Response. Clin Cancer Res. 2019 11 01; 25(21):6555. Gutkind JS, Day TA, Lippman SM, Szabo E. PMID: 31676588; PMCID: PMC10224677.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    86. Oral Cancer: Integration of Studies for Diagnostic and Therapeutic Precision. Adv Dent Res. 2019 11; 30(2):45-49. D'Silva NJ, Gutkind JS. PMID: 31633388; PMCID: PMC6806126.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    87. Establishment of a novel cancer cell line derived from vulvar carcinoma associated with lichen sclerosus exhibiting a fibroblast-dependent tumorigenic potential. Exp Cell Res. 2020 01 01; 386(1):111684. Dongre H, Rana N, Fromreide S, Rajthala S, Bøe Engelsen I, Paradis J, Gutkind JS, Vintermyr OK, Johannessen AC, Bjørge L, Costea DE. PMID: 31654625.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    88. Phase 1 dose-finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer. Cancer. 2020 01 15; 126(2):354-362. Gulati S, Desai J, Palackdharry SM, Morris JC, Zhu Z, Jandarov R, Riaz MK, Takiar V, Mierzwa M, Gutkind JS, Molinolo A, Desai PB, Sadraei NH, Wise-Draper TM. PMID: 31626727; PMCID: PMC10402880.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCTClinical Trials
    89. Cryo-electron microscopy structure and analysis of the P-Rex1-Gβγ signaling scaffold. Sci Adv. 2019 10; 5(10):eaax8855. Cash JN, Urata S, Li S, Ravala SK, Avramova LV, Shost MD, Gutkind JS, Tesmer JJG, Cianfrocco MA. PMID: 31663027; PMCID: PMC6795519.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    90. Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis. Sci Rep. 2019 08 12; 9(1):11666. Zahra FT, Sajib MS, Ichiyama Y, Akwii RG, Tullar PE, Cobos C, Minchew SA, Doçi CL, Zheng Y, Kubota Y, Gutkind JS, Mikelis CM. PMID: 31406143; PMCID: PMC6690958.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    91. Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm. Oncogene. 2019 09; 38(38):6491-6506. Raimondi F, Inoue A, Kadji FMN, Shuai N, Gonzalez JC, Singh G, de la Vega AA, Sotillo R, Fischer B, Aoki J, Gutkind JS, Russell RB. PMID: 31337866; PMCID: PMC6756116.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    92. Beyond Synthetic Lethality: Charting the Landscape of Pairwise Gene Expression States Associated with Survival in Cancer. Cell Rep. 2019 07 23; 28(4):938-948.e6. Magen A, Das Sahu A, Lee JS, Sharmin M, Lugo A, Gutkind JS, Schäffer AA, Ruppin E, Hannenhalli S. PMID: 31340155; PMCID: PMC8261641.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    93. Metformin Inhibits Progression of Head and Neck Squamous Cell Carcinoma by Acting Directly on Carcinoma-Initiating Cells. Cancer Res. 2019 09 01; 79(17):4360-4370. Wu X, Yeerna H, Goto Y, Ando T, Wu VH, Zhang X, Wang Z, Amornphimoltham P, Murphy AN, Tamayo P, Chen Q, Lippman SM, Gutkind JS. PMID: 31292160; PMCID: PMC6726568.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    94. PRECOG: PREdicting COupling probabilities of G-protein coupled receptors. Nucleic Acids Res. 2019 07 02; 47(W1):W395-W401. Singh G, Inoue A, Gutkind JS, Russell RB, Raimondi F. PMID: 31143927; PMCID: PMC6602504.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    95. Illuminating the Onco-GPCRome: Novel G protein-coupled receptor-driven oncocrine networks and targets for cancer immunotherapy. J Biol Chem. 2019 07 19; 294(29):11062-11086. Wu V, Yeerna H, Nohata N, Chiou J, Harismendy O, Raimondi F, Inoue A, Russell RB, Tamayo P, Gutkind JS. PMID: 31171722; PMCID: PMC6643028.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    96. Correction to: mTOR co-targeting strategies for head and neck cancer therapy. Cancer Metastasis Rev. 2019 Jun; 38(1-2):327. Wang Z, Valera JC, Zhao X, Chen Q, Gutkind JS. PMID: 30187213; PMCID: PMC6828528.
      View in: PubMed   Mentions:    Fields:    
    97. Illuminating G-Protein-Coupling Selectivity of GPCRs. Cell. 2019 06 13; 177(7):1933-1947.e25. Inoue A, Raimondi F, Kadji FMN, Singh G, Kishi T, Uwamizu A, Ono Y, Shinjo Y, Ishida S, Arang N, Kawakami K, Gutkind JS, Aoki J, Russell RB. PMID: 31160049; PMCID: PMC6773469.
      View in: PubMed   Mentions: 241     Fields:    Translation:HumansCells
    98. Effects of palbociclib on oral squamous cell carcinoma and the role of PIK3CA in conferring resistance. Cancer Biol Med. 2019 May; 16(2):264-275. Zainal NS, Lee BKB, Wong ZW, Chin IS, Yee PS, Gan CP, Mun KS, Rahman ZAA, Gutkind JS, Patel V, Cheong SC. PMID: 31516747; PMCID: PMC6713638.
      View in: PubMed   Mentions: 15     Fields:    
    99. 4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer. Cancer Res. 2019 04 01; 79(7):1438-1450. Wang Z, Feng X, Molinolo AA, Martin D, Vitale-Cross L, Nohata N, Ando M, Wahba A, Amornphimoltham P, Wu X, Gilardi M, Allevato M, Wu V, Steffen DJ, Tofilon P, Sonenberg N, Califano J, Chen Q, Lippman SM, Gutkind JS. PMID: 30894372; PMCID: PMC6445709.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    100. Direct targeting of Gαq and Gα11 oncoproteins in cancer cells. Sci Signal. 2019 03 19; 12(573). Annala S, Feng X, Shridhar N, Eryilmaz F, Patt J, Yang J, Pfeil EM, Cervantes-Villagrana RD, Inoue A, Häberlein F, Slodczyk T, Reher R, Kehraus S, Monteleone S, Schrage R, Heycke N, Rick U, Engel S, Pfeifer A, Kolb P, König G, Bünemann M, Tüting T, Vázquez-Prado J, Gutkind JS, Gaffal E, Kostenis E. PMID: 30890659.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    101. Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy. Mol Syst Biol. 2019 03 11; 15(3):e8323. Sahu AD, S Lee J, Wang Z, Zhang G, Iglesias-Bartolome R, Tian T, Wei Z, Miao B, Nair NU, Ponomarova O, Friedman AA, Amzallag A, Moll T, Kasumova G, Greninger P, Egan RK, Damon LJ, Frederick DT, Jerby-Arnon L, Wagner A, Cheng K, Park SG, Robinson W, Gardner K, Boland G, Hannenhalli S, Herlyn M, Benes C, Flaherty K, Luo J, Gutkind JS, Ruppin E. PMID: 30858180; PMCID: PMC6413886.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    102. Immune Modulation of Head and Neck Squamous Cell Carcinoma and the Tumor Microenvironment by Conventional Therapeutics. Clin Cancer Res. 2019 07 15; 25(14):4211-4223. Miyauchi S, Kim SS, Pang J, Gold KA, Gutkind JS, Califano JA, Mell LK, Cohen EEW, Sharabi AB. PMID: 30814108; PMCID: PMC6635035.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimals
    103. Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential. Sci Signal. 2019 02 19; 12(569). Bandekar SJ, Arang N, Tully ES, Tang BA, Barton BL, Li S, Gutkind JS, Tesmer JJG. PMID: 30783010; PMCID: PMC6519057.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    104. SOX2 Epidermal Overexpression Promotes Cutaneous Wound Healing via Activation of EGFR/MEK/ERK Signaling Mediated by EGFR Ligands. J Invest Dermatol. 2019 08; 139(8):1809-1820.e8. Uchiyama A, Nayak S, Graf R, Cross M, Hasneen K, Gutkind JS, Brooks SR, Morasso MI. PMID: 30772301; PMCID: PMC6650375.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    105. A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK. Cancer Cell. 2019 03 18; 35(3):457-472.e5. Feng X, Arang N, Rigiracciolo DC, Lee JS, Yeerna H, Wang Z, Lubrano S, Kishore A, Pachter JA, König GM, Maggiolini M, Kostenis E, Schlaepfer DD, Tamayo P, Chen Q, Ruppin E, Gutkind JS. PMID: 30773340; PMCID: PMC6737937.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    106. cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits. J Biol Chem. 2019 02 15; 294(7):2232-2246. Adame-García SR, Cervantes-Villagrana RD, Orduña-Castillo LB, Del Rio JC, Gutkind JS, Reyes-Cruz G, Taylor SS, Vázquez-Prado J. PMID: 30530493; PMCID: PMC6378977.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    107. Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gαq and Gα13 proteins. J Biol Chem. 2019 01 11; 294(2):531-546. Cervantes-Villagrana RD, Adame-García SR, García-Jiménez I, Color-Aparicio VM, Beltrán-Navarro YM, König GM, Kostenis E, Reyes-Cruz G, Gutkind JS, Vázquez-Prado J. PMID: 30446620; PMCID: PMC6333895.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    108. Inhibition of mTOR Signaling and Clinical Activity of Rapamycin in Head and Neck Cancer in a Window of Opportunity Trial. Clin Cancer Res. 2019 02 15; 25(4):1156-1164. Day TA, Shirai K, O'Brien PE, Matheus MG, Godwin K, Sood AJ, Kompelli A, Vick JA, Martin D, Vitale-Cross L, Callejas-Varela JL, Wang Z, Wu X, Harismendy O, Molinolo AA, Lippman SM, Van Waes C, Szabo E, Gutkind JS. PMID: 30420444; PMCID: PMC6377824.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    109. Arrestins as rheostats of GPCR signalling. Nat Rev Mol Cell Biol. 2018 10; 19(10):615-616. Gutkind JS, Kostenis E. PMID: 30026541.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    110. Development of a yeast-based system to identify new hBRAFV600E functional interactors. Oncogene. 2019 02; 38(8):1355-1366. Lubrano S, Comelli L, Piccirilli C, Marranci A, Dapporto F, Tantillo E, Gemignani F, Gutkind JS, Salvetti A, Chiorino G, Cozza G, Chiariello M, Galli A, Poliseno L, Cervelli T. PMID: 30237439.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    111. GNASR201C Induces Pancreatic Cystic Neoplasms in Mice That Express Activated KRAS by Inhibiting YAP1 Signaling. Gastroenterology. 2018 11; 155(5):1593-1607.e12. Ideno N, Yamaguchi H, Ghosh B, Gupta S, Okumura T, Steffen DJ, Fisher CG, Wood LD, Singhi AD, Nakamura M, Gutkind JS, Maitra A. PMID: 30142336; PMCID: PMC6219919.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    112. Transcriptional signature primes human oral mucosa for rapid wound healing. Sci Transl Med. 2018 07 25; 10(451). Iglesias-Bartolome R, Uchiyama A, Molinolo AA, Abusleme L, Brooks SR, Callejas-Valera JL, Edwards D, Doci C, Asselin-Labat ML, Onaitis MW, Moutsopoulos NM, Gutkind JS, Morasso MI. PMID: 30045979; PMCID: PMC6598699.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansCells
    113. The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras. J Biol Chem. 2018 Jul 20; 293(29):11651. Oliva JL, Zarich N, Martínez N, Jorge R, Castrillo A, Azañedo M, García-Vargas S, Gutiérrez-Eisman S, Juarranz A, Boscá L, Gutkind JS, Rojas JM. PMID: 30030386; PMCID: PMC6065178.
      View in: PubMed   Mentions:    Fields:    
    114. Assembly and activation of the Hippo signalome by FAT1 tumor suppressor. Nat Commun. 2018 07 09; 9(1):2372. Martin D, Degese MS, Vitale-Cross L, Iglesias-Bartolome R, Valera JLC, Wang Z, Feng X, Yeerna H, Vadmal V, Moroishi T, Thorne RF, Zaida M, Siegele B, Cheong SC, Molinolo AA, Samuels Y, Tamayo P, Guan KL, Lippman SM, Lyons JG, Gutkind JS. PMID: 29985391; PMCID: PMC6037762.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    115. Head and Neck Cancer in the New Era of Precision Medicine. J Dent Res. 2018 06; 97(6):601-602. Nör JE, Gutkind JS. PMID: 29771196.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    116. GENIPAC: A Genomic Information Portal for Head and Neck Cancer Cell Systems. J Dent Res. 2018 07; 97(8):909-916. Lee BKB, Gan CP, Chang JK, Tan JL, Fadlullah MZ, Abdul Rahman ZA, Prime SS, Gutkind JS, Liew CS, Khang TF, Tan AC, Cheong SC. PMID: 29512401.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    117. The homozygous CX3CR1-M280 mutation impairs human monocyte survival. JCI Insight. 2018 02 08; 3(3). Collar AL, Swamydas M, O'Hayre M, Sajib MS, Hoffman KW, Singh SP, Mourad A, Johnson MD, Ferre EM, Farber JM, Lim JK, Mikelis CM, Gutkind JS, Lionakis MS. PMID: 29415879; PMCID: PMC5821174.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    118. Expression of an active Gαs mutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance. Proc Natl Acad Sci U S A. 2018 01 16; 115(3):E428-E437. Zhao X, Deng P, Iglesias-Bartolome R, Amornphimoltham P, Steffen DJ, Jin Y, Molinolo AA, de Castro LF, Ovejero D, Yuan Q, Chen Q, Han X, Bai D, Taylor SS, Yang Y, Collins MT, Gutkind JS. PMID: 29282319; PMCID: PMC5776975.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    119. The NOTCH4-HEY1 Pathway Induces Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2018 02 01; 24(3):619-633. Fukusumi T, Guo TW, Sakai A, Ando M, Ren S, Haft S, Liu C, Amornphimoltham P, Gutkind JS, Califano JA. PMID: 29146722; PMCID: PMC6171749.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    120. The Next Frontier: Head and Neck Cancer Immunoprevention. Cancer Prev Res (Phila). 2017 Dec; 10(12):681-683. Gutkind JS, Bui JD. PMID: 29138137; PMCID: PMC5741293.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    121. Genetic variants affecting equivalent protein family positions reflect human diversity. Sci Rep. 2017 10 06; 7(1):12771. Raimondi F, Betts MJ, Lu Q, Inoue A, Gutkind JS, Russell RB. PMID: 28986545; PMCID: PMC5630595.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    122. mTOR co-targeting strategies for head and neck cancer therapy. Cancer Metastasis Rev. 2017 09; 36(3):491-502. Wang Z, Valera JC, Zhao X, Chen Q, Gutkind JS. PMID: 28822012; PMCID: PMC5613059.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    123. A Novel Functional Splice Variant of AKT3 Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers. Cancer Res. 2017 10 01; 77(19):5248-5258. Guo T, Sakai A, Afsari B, Considine M, Danilova L, Favorov AV, Yegnasubramanian S, Kelley DZ, Flam E, Ha PK, Khan Z, Wheelan SJ, Gutkind JS, Fertig EJ, Gaykalova DA, Califano J. PMID: 28733453; PMCID: PMC6042297.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    124. Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK. Sci Signal. 2017 Jun 20; 10(484). O'Hayre M, Eichel K, Avino S, Zhao X, Steffen DJ, Feng X, Kawakami K, Aoki J, Messer K, Sunahara R, Inoue A, von Zastrow M, Gutkind JS. PMID: 28634209; PMCID: PMC5751434.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    125. E1a is an exogenous in vivo tumour suppressor. Cancer Lett. 2017 07 28; 399:74-81. Cimas FJ, Callejas-Valera JL, García-Olmo DC, Hernández-Losa J, Melgar-Rojas P, Ruiz-Hidalgo MJ, Pascual-Serra R, Ortega-Muelas M, Roche O, Marcos P, Garcia-Gil E, Fernandez-Aroca DM, Ramón Y Cajal S, Gutkind JS, Sanchez-Prieto R. PMID: 28416454.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    126. Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes. PLoS One. 2017; 12(3):e0173692. Doçi CL, Mikelis CM, Callejas-Valera JL, Hansen KK, Molinolo AA, Inoue A, Offermanns S, Gutkind JS. PMID: 28301547; PMCID: PMC5354386.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    127. Integrative computational analysis of transcriptional and epigenetic alterations implicates DTX1 as a putative tumor suppressor gene in HNSCC. Oncotarget. 2017 Feb 28; 8(9):15349-15363. Gaykalova DA, Zizkova V, Guo T, Tiscareno I, Wei Y, Vatapalli R, Hennessey PT, Ahn J, Danilova L, Khan Z, Bishop JA, Gutkind JS, Koch WM, Westra WH, Fertig EJ, Ochs MF, Califano JA. PMID: 28146432; PMCID: PMC5362490.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    128. Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer. Cancer Discov. 2017 04; 7(4):410-423. Carter H, Marty R, Hofree M, Gross AM, Jensen J, Fisch KM, Wu X, DeBoever C, Van Nostrand EL, Song Y, Wheeler E, Kreisberg JF, Lippman SM, Yeo GW, Gutkind JS, Ideker T. PMID: 28188128; PMCID: PMC5460679.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    129. Using Heterologous COS-7 Cells to Identify Semaphorin-Signaling Components. Methods Mol Biol. 2017; 1493:163-170. Sakurai A, Doçi CL, Gutkind JS. PMID: 27787849.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    130. Onco-GPCR signaling and dysregulated expression of microRNAs in human cancer. J Hum Genet. 2017 Jan; 62(1):87-96. Nohata N, Goto Y, Gutkind JS. PMID: 27734836.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    131. LAG-3 confers poor prognosis and its blockade reshapes antitumor response in head and neck squamous cell carcinoma. Oncoimmunology. 2016; 5(11):e1239005. Deng WW, Mao L, Yu GT, Bu LL, Ma SR, Liu B, Gutkind JS, Kulkarni AB, Zhang WF, Sun ZJ. PMID: 27999760; PMCID: PMC5139652.
      View in: PubMed   Mentions: 66     Fields:    
    132. mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model. Carcinogenesis. 2016 10; 37(10):1014-25. Callejas-Valera JL, Iglesias-Bartolome R, Amornphimoltham P, Palacios-Garcia J, Martin D, Califano JA, Molinolo AA, Gutkind JS. PMID: 27538837; PMCID: PMC6276901.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    133. Unraveling the oral cancer lncRNAome: Identification of novel lncRNAs associated with malignant progression and HPV infection. Oral Oncol. 2016 08; 59:58-66. Nohata N, Abba MC, Gutkind JS. PMID: 27424183; PMCID: PMC5729891.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    134. Liver kinase B1 regulates hepatocellular tight junction distribution and function in vivo. Hepatology. 2016 10; 64(4):1317-29. Porat-Shliom N, Tietgens AJ, Van Itallie CM, Vitale-Cross L, Jarnik M, Harding OJ, Anderson JM, Gutkind JS, Weigert R, Arias IM. PMID: 27396550; PMCID: PMC5033699.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    135. Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer. Oncotarget. 2016 07 26; 7(30):47565-47575. Andradas C, Blasco-Benito S, Castillo-Lluva S, Dillenburg-Pilla P, Diez-Alarcia R, Juanes-García A, García-Taboada E, Hernando-Llorente R, Soriano J, Hamann S, Wenners A, Alkatout I, Klapper W, Rocken C, Bauer M, Arnold N, Quintanilla M, Megías D, Vicente-Manzanares M, Urigüen L, Gutkind JS, Guzmán M, Pérez-Gómez E, Sánchez C. PMID: 27340777; PMCID: PMC5216961.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    136. WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Gα12/13. Mol Pharmacol. 2016 10; 90(4):447-59. Arthofer E, Hot B, Petersen J, Strakova K, Jäger S, Grundmann M, Kostenis E, Gutkind JS, Schulte G. PMID: 27458145; PMCID: PMC5034691.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    137. PI3K pathway is involved in ERK signaling cascade activation by histamine H2R agonist in HEK293T cells. Biochim Biophys Acta. 2016 09; 1860(9):1998-2007. Alonso N, Diaz Nebreda A, Monczor F, Gutkind JS, Davio C, Fernandez N, Shayo C. PMID: 27316323.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    138. Phase II trial of everolimus in patients with previously treated recurrent or metastatic head and neck squamous cell carcinoma. Head Neck. 2016 12; 38(12):1759-1764. Geiger JL, Bauman JE, Gibson MK, Gooding WE, Varadarajan P, Kotsakis A, Martin D, Gutkind JS, Hedberg ML, Grandis JR, Argiris A. PMID: 27232378; PMCID: PMC6820341.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCTClinical Trials
    139. Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies. Oncotarget. 2016 May 10; 7(19):27802-18. Fadlullah MZ, Chiang IK, Dionne KR, Yee PS, Gan CP, Sam KK, Tiong KH, Ng AK, Martin D, Lim KP, Kallarakkal TG, Mustafa WM, Lau SH, Abraham MT, Zain RB, Rahman ZA, Molinolo A, Patel V, Gutkind JS, Tan AC, Cheong SC. PMID: 27050151; PMCID: PMC5053689.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    140. NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell. Sci Rep. 2016 04 25; 6:24704. Zhao ZL, Zhang L, Huang CF, Ma SR, Bu LL, Liu JF, Yu GT, Liu B, Gutkind JS, Kulkarni AB, Zhang WF, Sun ZJ. PMID: 27108536; PMCID: PMC4842967.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    141. Circulating Fibroblast Growth Factor-2, HIV-Tat, and Vascular Endothelial Cell Growth Factor-A in HIV-Infected Children with Renal Disease Activate Rho-A and Src in Cultured Renal Endothelial Cells. PLoS One. 2016; 11(4):e0153837. Das JR, Gutkind JS, Ray PE. PMID: 27097314; PMCID: PMC4838216.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    142. Prevention of irradiation-induced salivary hypofunction by rapamycin in swine parotid glands. Oncotarget. 2016 Apr 12; 7(15):20271-81. Zhu Z, Pang B, Iglesias-Bartolome R, Wu X, Hu L, Zhang C, Wang J, Gutkind JS, Wang S. PMID: 26958808; PMCID: PMC4991453.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    143. Signals and Receptors. Cold Spring Harb Perspect Biol. 2016 Apr 01; 8(4):a005900. Heldin CH, Lu B, Evans R, Gutkind JS. PMID: 27037414; PMCID: PMC4817805.
      View in: PubMed   Mentions: 72     Fields:    Translation:Cells
    144. A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers. Oncotarget. 2016 Mar 08; 7(10):10696-709. Yamaguchi K, Iglesias-Bartolomé R, Wang Z, Callejas-Valera JL, Amornphimoltham P, Molinolo AA, Cohen EE, Califano JA, Lippman SM, Luo J, Gutkind JS. PMID: 26882569; PMCID: PMC4905432.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    145. Combined image guided monitoring the pharmacokinetics of rapamycin loaded human serum albumin nanoparticles with a split luciferase reporter. Nanoscale. 2016 Feb 21; 8(7):3991-4000. Wang F, Yang K, Wang Z, Ma Y, Gutkind JS, Hida N, Niu G, Tian J. PMID: 26818100; PMCID: PMC4753573.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    146. Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis. Dev Biol. 2016 Mar 15; 411(2):183-194. Nohata N, Uchida Y, Stratman AN, Adams RH, Zheng Y, Weinstein BM, Mukouyama YS, Gutkind JS. PMID: 26872874.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    147. Erlotinib and the Risk of Oral Cancer: The Erlotinib Prevention of Oral Cancer (EPOC) Randomized Clinical Trial. JAMA Oncol. 2016 Feb; 2(2):209-16. William WN, Papadimitrakopoulou V, Lee JJ, Mao L, Cohen EE, Lin HY, Gillenwater AM, Martin JW, Lingen MW, Boyle JO, Shin DM, Vigneswaran N, Shinn N, Heymach JV, Wistuba II, Tang X, Kim ES, Saintigny P, Blair EA, Meiller T, Gutkind JS, Myers J, El-Naggar A, Lippman SM. PMID: 26540028; PMCID: PMC4771491.
      View in: PubMed   Mentions: 68     Fields:    Translation:Humans
    148. MKP1 mediates chemosensitizer effects of E1a in response to cisplatin in non-small cell lung carcinoma cells. Oncotarget. 2015 Dec 29; 6(42):44095-107. Cimas FJ, Callejas-Valera JL, Pascual-Serra R, García-Cano J, Garcia-Gil E, De la Cruz-Morcillo MA, Ortega-Muelas M, Serrano-Oviedo L, Gutkind JS, Sánchez-Prieto R. PMID: 26689986; PMCID: PMC4792544.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    149. PD-1 blockade attenuates immunosuppressive myeloid cells due to inhibition of CD47/SIRPα axis in HPV negative head and neck squamous cell carcinoma. Oncotarget. 2015 Dec 08; 6(39):42067-80. Yu GT, Bu LL, Huang CF, Zhang WF, Chen WJ, Gutkind JS, Kulkarni AB, Sun ZJ. PMID: 26573233; PMCID: PMC4747210.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    150. Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells. Oncogene. 2016 07 21; 35(29):3771-80. O'Hayre M, Inoue A, Kufareva I, Wang Z, Mikelis CM, Drummond RA, Avino S, Finkel K, Kalim KW, DiPasquale G, Guo F, Aoki J, Zheng Y, Lionakis MS, Molinolo AA, Gutkind JS. PMID: 26616858; PMCID: PMC4885800.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    151. Sonic Hedgehog in SCLC. Aging (Albany NY). 2015 Sep; 7(9):605-6. Laukkanen MO, Gutkind JS, Castellone MD. PMID: 26420823; PMCID: PMC4600616.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    152. Voltage-gated Na+ Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling. Sci Rep. 2015 Jun 22; 5:11541. House CD, Wang BD, Ceniccola K, Williams R, Simaan M, Olender J, Patel V, Baptista-Hon DT, Annunziata CM, Gutkind JS, Hales TG, Lee NH. PMID: 26096612; PMCID: PMC4476109.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    153. Polymeric Nanovehicle Regulated Spatiotemporal Real-Time Imaging of the Differentiation Dynamics of Transplanted Neural Stem Cells after Traumatic Brain Injury. ACS Nano. 2015 Jul 28; 9(7):6683-95. Wang Z, Wang Y, Wang Z, Zhao J, Gutkind JS, Srivatsan A, Zhang G, Liao HS, Fu X, Jin A, Tong X, Niu G, Chen X. PMID: 26020550; PMCID: PMC5238514.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    154. Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis. Nat Cell Biol. 2015 Jun; 17(6):793-803. Iglesias-Bartolome R, Torres D, Marone R, Feng X, Martin D, Simaan M, Chen M, Weinstein LS, Taylor SS, Molinolo AA, Gutkind JS. PMID: 25961504; PMCID: PMC4449815.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    155. Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma. Cancer Res. 2015 Jul 15; 75(14):2937-48. Doçi CL, Mikelis CM, Lionakis MS, Molinolo AA, Gutkind JS. PMID: 25952650; PMCID: PMC4538958.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    156. RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock. Nat Commun. 2015 Apr 10; 6:6725. Mikelis CM, Simaan M, Ando K, Fukuhara S, Sakurai A, Amornphimoltham P, Masedunskas A, Weigert R, Chavakis T, Adams RH, Offermanns S, Mochizuki N, Zheng Y, Gutkind JS. PMID: 25857352; PMCID: PMC4394241.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    157. An interplay between the p38 MAPK pathway and AUBPs regulates c-fos mRNA stability during mitogenic stimulation. Biochem J. 2015 Apr 01; 467(1):77-90. Degese MS, Tanos T, Naipauer J, Gingerich T, Chiappe D, Echeverria P, LaMarre J, Gutkind JS, Coso OA. PMID: 25588078; PMCID: PMC9318795.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    158. Levels of sirolimus in saliva and blood following oral topical sustained-release varnish delivery system application. Cancer Chemother Pharmacol. 2015 May; 75(5):969-74. Nudelman Z, Findler M, Barasch D, Nemirovski A, Pikovsky A, Kirmayer D, Basheer M, Gutkind JS, Friedman M, Czerninski R. PMID: 25757961.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    159. Prevention of tumor growth driven by PIK3CA and HPV oncogenes by targeting mTOR signaling with metformin in oral squamous carcinomas expressing OCT3. Cancer Prev Res (Phila). 2015 Mar; 8(3):197-207. Madera D, Vitale-Cross L, Martin D, Schneider A, Molinolo AA, Gangane N, Carey TE, McHugh JB, Komarck CM, Walline HM, William WN, Seethala RR, Ferris RL, Gutkind JS. PMID: 25681087; PMCID: PMC4355306.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    160. Fluorescent, bioactive protein nanoparticles (prodots) for rapid, improved cellular uptake. Bioconjug Chem. 2015 Mar 18; 26(3):396-404. Deshapriya IK, Stromer BS, Pattammattel A, Kim CS, Iglesias-Bartolome R, Gonzalez-Fajardo L, Patel V, Gutkind JS, Lu X, Kumar CV. PMID: 25642999.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    161. Engineered mesenchymal stem cells with enhanced tropism and paracrine secretion of cytokines and growth factors to treat traumatic brain injury. Stem Cells. 2015 Feb; 33(2):456-67. Wang Z, Wang Y, Wang Z, Gutkind JS, Wang Z, Wang F, Lu J, Niu G, Teng G, Chen X. PMID: 25346537.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    162. SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis. FASEB J. 2015 Mar; 29(3):1056-68. Dillenburg-Pilla P, Patel V, Mikelis CM, Zárate-Bladés CR, Doçi CL, Amornphimoltham P, Wang Z, Martin D, Leelahavanichkul K, Dorsam RT, Masedunskas A, Weigert R, Molinolo AA, Gutkind JS. PMID: 25466898; PMCID: PMC4422355.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    163. Oncotargeting G proteins: The Hippo in the room. Oncotarget. 2014 Nov 30; 5(22):10997-9. Feng X, Chen Q, Gutkind JS. PMID: 25526026; PMCID: PMC4294369.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    164. A systems genetics approach identifies CXCL14, ITGAX, and LPCAT2 as novel aggressive prostate cancer susceptibility genes. PLoS Genet. 2014 Nov; 10(11):e1004809. Williams KA, Lee M, Hu Y, Andreas J, Patel SJ, Zhang S, Chines P, Elkahloun A, Chandrasekharappa S, Gutkind JS, Molinolo AA, Crawford NP. PMID: 25411967; PMCID: PMC4238980.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    165. Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis. Oncotarget. 2014 Oct 30; 5(20):9626-40. Gan CP, Patel V, Mikelis CM, Zain RB, Molinolo AA, Abraham MT, Teo SH, Abdul Rahman ZA, Gutkind JS, Cheong SC. PMID: 25275299; PMCID: PMC4259425.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    166. The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies. Oncotarget. 2014 Oct 15; 5(19):8906-23. Martin D, Abba MC, Molinolo AA, Vitale-Cross L, Wang Z, Zaida M, Delic NC, Samuels Y, Lyons JG, Gutkind JS. PMID: 25275298; PMCID: PMC4253406.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansCells
    167. Cholecystokinin receptor antagonist halts progression of pancreatic cancer precursor lesions and fibrosis in mice. Pancreas. 2014 Oct; 43(7):1050-9. Smith JP, Cooper TK, McGovern CO, Gilius EL, Zhong Q, Liao J, Molinolo AA, Gutkind JS, Matters GL. PMID: 25058882; PMCID: PMC4161619.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    168. Insights into β2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3. Protein Sci. 2014 Dec; 23(12):1708-16. Qi S, O'Hayre M, Gutkind JS, Hurley JH. PMID: 25220262; PMCID: PMC4253811.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    169. Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway. Oncogene. 2015 Jul; 34(27):3536-46. Liu G, Yu FX, Kim YC, Meng Z, Naipauer J, Looney DJ, Liu X, Gutkind JS, Mesri EA, Guan KL. PMID: 25195862; PMCID: PMC4721508.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    170. Biology of advanced uveal melanoma and next steps for clinical therapeutics. Pigment Cell Melanoma Res. 2015 Mar; 28(2):135-47. Luke JJ, Triozzi PL, McKenna KC, Van Meir EG, Gershenwald JE, Bastian BC, Gutkind JS, Bowcock AM, Streicher HZ, Patel PM, Sato T, Sossman JA, Sznol M, Welch J, Thurin M, Selig S, Flaherty KT, Carvajal RD. PMID: 25113308; PMCID: PMC4326637.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    171. mTOR co-targeting in cetuximab resistance in head and neck cancers harboring PIK3CA and RAS mutations. J Natl Cancer Inst. 2014 Sep; 106(9). Wang Z, Martin D, Molinolo AA, Patel V, Iglesias-Bartolome R, Degese MS, Vitale-Cross L, Chen Q, Gutkind JS. PMID: 25099740; PMCID: PMC4133928.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    172. Melanoma cell lysate induces CCR7 expression and in vivo migration to draining lymph nodes of therapeutic human dendritic cells. Immunology. 2014 Jul; 142(3):396-405. González FE, Ortiz C, Reyes M, Dutzan N, Patel V, Pereda C, Gleisner MA, López MN, Gutkind JS, Salazar-Onfray F. PMID: 24673602; PMCID: PMC4080955.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    173. Dermatomyositis paraneoplastic syndrome before symptomatic tonsillar squamous cell carcinoma: a case report. Head Neck. 2015 Jan; 37(1):E1-3. Adi AH, Alturkmani H, Spock T, Williams Yohannes P, Wargo S, Szabo E, Gutkind JS, Van Waes C. PMID: 24715579.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    174. Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. Cancer Cell. 2014 Jun 16; 25(6):831-45. Feng X, Degese MS, Iglesias-Bartolome R, Vaque JP, Molinolo AA, Rodrigues M, Zaidi MR, Ksander BR, Merlino G, Sodhi A, Chen Q, Gutkind JS. PMID: 24882515; PMCID: PMC4074519.
      View in: PubMed   Mentions: 303     Fields:    Translation:HumansAnimalsCells
    175. Cross talk between the bombesin neuropeptide receptor and Sonic hedgehog pathways in small cell lung carcinoma. Oncogene. 2015 Mar 26; 34(13):1679-87. Castellone MD, Laukkanen MO, Teramoto H, Bellelli R, Alì G, Fontanini G, Santoro M, Gutkind JS. PMID: 24747971; PMCID: PMC4539617.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    176. Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation. J Invest Dermatol. 2014 Sep; 134(9):2390-2398. Prickett TD, Zerlanko BJ, Hill VK, Gartner JJ, Qutob N, Jiang J, Simaan M, Wunderlich J, Gutkind JS, Rosenberg SA, Samuels Y. PMID: 24739903; PMCID: PMC4134353.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    177. Targeted therapeutic nanotubes influence the viscoelasticity of cancer cells to overcome drug resistance. ACS Nano. 2014 May 27; 8(5):4177-89. Bhirde AA, Chikkaveeraiah BV, Srivatsan A, Niu G, Jin AJ, Kapoor A, Wang Z, Patel S, Patel V, Gorbach AM, Leapman RD, Gutkind JS, Hight Walker AR, Chen X. PMID: 24708375; PMCID: PMC4046789.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    178. Levels of sirolimus in saliva and blood following mouthwash application. Oral Dis. 2014 Nov; 20(8):768-72. Nudelman Z, Friedman M, Barasch D, Nemirovski A, Findler M, Pikovsky A, Gutkind J, Czerninski R. PMID: 24548545.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    179. LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes. PLoS One. 2014; 9(3):e91921. Homolya L, Fu D, Sengupta P, Jarnik M, Gillet JP, Vitale-Cross L, Gutkind JS, Lippincott-Schwartz J, Arias IM. PMID: 24643070; PMCID: PMC3958433.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    180. The basic domain of HIV-tat transactivating protein is essential for its targeting to lipid rafts and regulating fibroblast growth factor-2 signaling in podocytes isolated from children with HIV-1-associated nephropathy. J Am Soc Nephrol. 2014 Aug; 25(8):1800-13. Xie X, Colberg-Poley AM, Das JR, Li J, Zhang A, Tang P, Jerebtsova M, Gutkind JS, Ray PE. PMID: 24578133; PMCID: PMC4116058.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    181. Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models. Mol Cancer. 2014 Feb 20; 13:32. Sobral LM, Sousa LO, Coletta RD, Cabral H, Greene LJ, Tajara EH, Gutkind JS, Curti C, Leopoldino AM. PMID: 24555657; PMCID: PMC3936887.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    182. Brag2 differentially regulates β1- and β3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis. Basic Res Cardiol. 2014 Mar; 109(2):404. Manavski Y, Carmona G, Bennewitz K, Tang Z, Zhang F, Sakurai A, Zeiher AM, Gutkind JS, Li X, Kroll J, Dimmeler S, Chavakis E. PMID: 24522833.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    183. Novel insights into G protein and G protein-coupled receptor signaling in cancer. Curr Opin Cell Biol. 2014 Apr; 27:126-35. O'Hayre M, Degese MS, Gutkind JS. PMID: 24508914; PMCID: PMC4021379.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansAnimalsCells
    184. Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis. Oncogene. 2015 Jan 15; 34(3):346-56. Sales KU, Friis S, Konkel JE, Godiksen S, Hatakeyama M, Hansen KK, Rogatto SR, Szabo R, Vogel LK, Chen W, Gutkind JS, Bugge TH. PMID: 24469043; PMCID: PMC4112178.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    185. Structural and biochemical basis for ubiquitin ligase recruitment by arrestin-related domain-containing protein-3 (ARRDC3). J Biol Chem. 2014 Feb 21; 289(8):4743-52. Qi S, O'Hayre M, Gutkind JS, Hurley JH. PMID: 24379409; PMCID: PMC3931036.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    186. Impairing squamous differentiation by Klf4 deletion is sufficient to initiate tongue carcinoma development upon K-Ras activation in mice. Carcinogenesis. 2014 Mar; 35(3):662-9. Abrigo M, Alvarez R, Paparella ML, Calb DE, Bal de Kier Joffe E, Gutkind JS, Raimondi AR. PMID: 24148820.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    187. Massively parallel sequencing reveals an accumulation of de novo mutations and an activating mutation of LPAR1 in a patient with metastatic neuroblastoma. PLoS One. 2013; 8(10):e77731. Wei JS, Johansson P, Chen L, Song YK, Tolman C, Li S, Hurd L, Patidar R, Wen X, Badgett TC, Cheuk AT, Marshall JC, Steeg PS, Vaqué Díez JP, Yu Y, Gutkind JS, Khan J. PMID: 24147068; PMCID: PMC3797724.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    188. A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesis. Mol Oncol. 2014 Feb; 8(1):105-18. Leelahavanichkul K, Amornphimoltham P, Molinolo AA, Basile JR, Koontongkaew S, Gutkind JS. PMID: 24216180; PMCID: PMC3946852.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    189. Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study. J Biol Chem. 2013 Nov 22; 288(47):34030-34040. Artamonov MV, Momotani K, Stevenson A, Trentham DR, Derewenda U, Derewenda ZS, Read PW, Gutkind JS, Somlyo AV. PMID: 24106280; PMCID: PMC3837142.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    190. Exploiting the head and neck cancer oncogenome: widespread PI3K-mTOR pathway alterations and novel molecular targets. Cancer Discov. 2013 Jul; 3(7):722-5. Iglesias-Bartolome R, Martin D, Gutkind JS. PMID: 23847349; PMCID: PMC4348071.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    191. IKK epsilon kinase is crucial for viral G protein-coupled receptor tumorigenesis. Proc Natl Acad Sci U S A. 2013 Jul 02; 110(27):11139-44. Wang Y, Lu X, Zhu L, Shen Y, Chengedza S, Feng H, Wang L, Jung JU, Gutkind JS, Gutkind JS, Feng P. PMID: 23771900; PMCID: PMC3703966.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    192. Rapid microfluidic immunoassays of cancer biomarker proteins using disposable inkjet-printed gold nanoparticle arrays. ChemistryOpen. 2013 Aug; 2(4):141-5. Krause CE, Otieno BA, Latus A, Faria RC, Patel V, Gutkind JS, Rusling JF. PMID: 24482763; PMCID: PMC3775520.
      View in: PubMed   Mentions: 20     Fields:    
    193. Improved clearance during treatment of HPV-positive head and neck cancer through mTOR inhibition. Neoplasia. 2013 Jun; 15(6):620-30. Coppock JD, Wieking BG, Molinolo AA, Gutkind JS, Miskimins WK, Lee JH. PMID: 23730210; PMCID: PMC3664994.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    194. Accumulation of dephosphorylated 4EBP after mTOR inhibition with rapamycin is sufficient to disrupt paracrine transformation by the KSHV vGPCR oncogene. Oncogene. 2014 May 01; 33(18):2405-12. Martin D, Nguyen Q, Molinolo A, Gutkind JS. PMID: 23708663.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    195. The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. Nat Rev Cancer. 2013 06; 13(6):412-24. O'Hayre M, Vázquez-Prado J, Kufareva I, Stawiski EW, Handel TM, Seshagiri S, Gutkind JS. PMID: 23640210; PMCID: PMC4068741.
      View in: PubMed   Mentions: 297     Fields:    Translation:HumansAnimalsCells
    196. PTEN deficiency contributes to the development and progression of head and neck cancer. Neoplasia. 2013 May; 15(5):461-71. Squarize CH, Castilho RM, Abrahao AC, Molinolo A, Lingen MW, Gutkind JS. PMID: 23633918; PMCID: PMC3638349.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    197. Germline genetic variation modulates tumor progression and metastasis in a mouse model of neuroendocrine prostate carcinoma. PLoS One. 2013; 8(4):e61848. Patel SJ, Molinolo AA, Gutkind S, Crawford NP. PMID: 23620793; PMCID: PMC3631138.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    198. Epigenetics, noncoding RNAs, and cell signaling--crossroads in the regulation of cell fate decisions. Curr Opin Cell Biol. 2013 Apr; 25(2):149-51. Blelloch R, Gutkind JS. PMID: 23498659.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    199. Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis. Nat Med. 2013 Apr; 19(4):421-8. Han G, Bian L, Li F, Cotrim A, Wang D, Lu J, Deng Y, Bird G, Sowers A, Mitchell JB, Gutkind JS, Zhao R, Raben D, ten Dijke P, Refaeli Y, Zhang Q, Wang XJ. PMID: 23475202; PMCID: PMC3780964.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCellsPHPublic Health
    200. PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation. J Biol Chem. 2013 Apr 26; 288(17):12232-43. Mikelis CM, Palmby TR, Simaan M, Li W, Szabo R, Lyons R, Martin D, Yagi H, Fukuhara S, Chikumi H, Galisteo R, Mukouyama YS, Bugge TH, Gutkind JS. PMID: 23467409; PMCID: PMC3636907.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    201. Cross-desensitization and cointernalization of H1 and H2 histamine receptors reveal new insights into histamine signal integration. Mol Pharmacol. 2013 May; 83(5):1087-98. Alonso N, Fernandez N, Notcovich C, Monczor F, Simaan M, Baldi A, Gutkind JS, Davio C, Shayo C. PMID: 23462507; PMCID: PMC3629830.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    202. Control of the epithelial stem cell epigenome: the shaping of epithelial stem cell identity. Curr Opin Cell Biol. 2013 Apr; 25(2):162-9. Iglesias-Bartolome R, Callejas-Valera JL, Gutkind JS. PMID: 23434069.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    203. Exploiting PI3K/mTOR signaling to accelerate epithelial wound healing. Oral Dis. 2013 Sep; 19(6):551-8. Castilho RM, Squarize CH, Gutkind JS. PMID: 23379329; PMCID: PMC4764999.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    204. TRAIL induces apoptosis in oral squamous carcinoma cells--a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5. Oncotarget. 2013 Feb; 4(2):206-17. Chen JJ, Mikelis CM, Zhang Y, Gutkind JS, Zhang B. PMID: 23470485; PMCID: PMC3712567.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    205. Rab25 regulates invasion and metastasis in head and neck cancer. Clin Cancer Res. 2013 Mar 15; 19(6):1375-88. Amornphimoltham P, Rechache K, Thompson J, Masedunskas A, Leelahavanichkul K, Patel V, Molinolo A, Gutkind JS, Weigert R. PMID: 23340300; PMCID: PMC3602237.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    206. Oral and pharyngeal epithelial keratinocyte culture. Methods Mol Biol. 2013; 945:67-79. Leelahavanichkul K, Gutkind JS. PMID: 23097101.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    207. Heparin inhibits angiotensin II-induced vasoconstriction on isolated mouse mesenteric resistance arteries through Rho-A- and PKA-dependent pathways. Vascul Pharmacol. 2013 Apr; 58(4):313-8. Xie-Zukauskas H, Das J, Short BL, Gutkind JS, Ray PE. PMID: 23268358; PMCID: PMC3606668.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    208. SET overexpression decreases cell detoxification efficiency: ALDH2 and GSTP1 are downregulated, DDR is impaired and DNA damage accumulates. FEBS J. 2012 Dec; 279(24):4615-28. Almeida LO, Goto RN, Pestana CR, Uyemura SA, Gutkind S, Curti C, Leopoldino AM. PMID: 23106910.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    209. A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors. Mol Cell. 2013 Jan 10; 49(1):94-108. Vaqué JP, Dorsam RT, Feng X, Iglesias-Bartolome R, Forsthoefel DJ, Chen Q, Debant A, Seeger MA, Ksander BR, Teramoto H, Gutkind JS. PMID: 23177739; PMCID: PMC3545055.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    210. Longitudinal imaging studies of tumor microenvironment in mice treated with the mTOR inhibitor rapamycin. PLoS One. 2012; 7(11):e49456. Saito K, Matsumoto S, Yasui H, Devasahayam N, Subramanian S, Munasinghe JP, Patel V, Gutkind JS, Mitchell JB, Krishna MC. PMID: 23185335; PMCID: PMC3502528.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    211. Molecular mechanisms deployed by virally encoded G protein-coupled receptors in human diseases. Annu Rev Pharmacol Toxicol. 2013; 53:331-54. Montaner S, Kufareva I, Abagyan R, Gutkind JS. PMID: 23092247; PMCID: PMC4074518.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    212. Exploiting the mTOR paradox for disease prevention. Oncotarget. 2012 Oct; 3(10):1061-3. Iglesias-Bartolome R, Gutkind JS. PMID: 23165441; PMCID: PMC3717954.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    213. DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays. Oral Oncol. 2013 Feb; 49(2):93-101. Patel V, Martin D, Malhotra R, Marsh CA, Doçi CL, Veenstra TD, Nathan CA, Sinha UK, Singh B, Molinolo AA, Rusling JF, Gutkind JS. PMID: 23010602; PMCID: PMC3546158.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    214. p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model. Cancer Res. 2012 Nov 15; 72(22):5966-75. Chow HY, Jubb AM, Koch JN, Jaffer ZM, Stepanova D, Campbell DA, Duron SG, O'Farrell M, Cai KQ, Klein-Szanto AJ, Gutkind JS, Hoeflich KP, Chernoff J. PMID: 22983922; PMCID: PMC3500416.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    215. mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis. Cell Stem Cell. 2012 Sep 07; 11(3):401-14. Iglesias-Bartolome R, Patel V, Cotrim A, Leelahavanichkul K, Molinolo AA, Mitchell JB, Gutkind JS. PMID: 22958932; PMCID: PMC3477550.
      View in: PubMed   Mentions: 166     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    216. Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation. PLoS Genet. 2012; 8(8):e1002937. Szabo R, Uzzun Sales K, Kosa P, Shylo NA, Godiksen S, Hansen KK, Friis S, Gutkind JS, Vogel LK, Hummler E, Camerer E, Bugge TH. PMID: 22952456; PMCID: PMC3431340.
      View in: PubMed   Mentions: 45     Fields:    Translation:Animals
    217. Role of GRB2-associated binder 1 in epidermal growth factor receptor-induced signaling in head and neck squamous cell carcinoma. Int J Cancer. 2013 Mar 01; 132(5):1042-50. Hoeben A, Martin D, Clement PM, Cools J, Gutkind JS. PMID: 22865653; PMCID: PMC3498529.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    218. Chemopreventive and chemotherapeutic actions of mTOR inhibitor in genetically defined head and neck squamous cell carcinoma mouse model. Clin Cancer Res. 2012 Oct 01; 18(19):5304-13. Sun ZJ, Zhang L, Hall B, Bian Y, Gutkind JS, Kulkarni AB. PMID: 22859719; PMCID: PMC3463723.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    219. Ultrasensitive detection of cancer biomarkers in the clinic by use of a nanostructured microfluidic array. Anal Chem. 2012 Jul 17; 84(14):6249-55. Malhotra R, Patel V, Chikkaveeraiah BV, Munge BS, Cheong SC, Zain RB, Abraham MT, Dey DK, Gutkind JS, Rusling JF. PMID: 22697359; PMCID: PMC3418660.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimals
    220. Activation of the mTOR pathway in primary medullary thyroid carcinoma and lymph node metastases. Clin Cancer Res. 2012 Jul 01; 18(13):3532-40. Tamburrino A, Molinolo AA, Salerno P, Chernock RD, Raffeld M, Xi L, Gutkind JS, Moley JF, Wells SA, Santoro M. PMID: 22753663.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    221. CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis. Blood. 2012 Jul 12; 120(2):489-98. Pan W, Pham VN, Stratman AN, Castranova D, Kamei M, Kidd KR, Lo BD, Shaw KM, Torres-Vazquez J, Mikelis CM, Gutkind JS, Davis GE, Weinstein BM. PMID: 22649102; PMCID: PMC3398756.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    222. Nuclear localization of heme oxygenase-1 is associated with tumor progression of head and neck squamous cell carcinomas. Exp Mol Pathol. 2012 Oct; 93(2):237-45. Gandini NA, Fermento ME, Salomón DG, Blasco J, Patel V, Gutkind JS, Molinolo AA, Facchinetti MM, Curino AC. PMID: 22580187.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimals
    223. Nuclear mapping of nanodrug delivery systems in dynamic cellular environments. ACS Nano. 2012 Jun 26; 6(6):4966-72. Bhirde AA, Kapoor A, Liu G, Iglesias-Bartolome R, Jin A, Zhang G, Xing R, Lee S, Leapman RD, Gutkind JS, Chen X. PMID: 22540867; PMCID: PMC3383922.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    224. Receptor tyrosine kinases activate canonical WNT/β-catenin signaling via MAP kinase/LRP6 pathway and direct β-catenin phosphorylation. PLoS One. 2012; 7(4):e35826. Krejci P, Aklian A, Kaucka M, Sevcikova E, Prochazkova J, Masek JK, Mikolka P, Pospisilova T, Spoustova T, Weis M, Paznekas WA, Wolf JH, Gutkind JS, Wilcox WR, Kozubik A, Jabs EW, Bryja V, Salazar L, Vesela I, Balek L. PMID: 22558232; PMCID: PMC3338780.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    225. Oncogene-induced senescence results in marked metabolic and bioenergetic alterations. Cell Cycle. 2012 Apr 01; 11(7):1383-92. Quijano C, Cao L, Fergusson MM, Romero H, Liu J, Gutkind S, Rovira II, Mohney RP, Karoly ED, Finkel T. PMID: 22421146; PMCID: PMC3350879.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    226. Metformin prevents the development of oral squamous cell carcinomas from carcinogen-induced premalignant lesions. Cancer Prev Res (Phila). 2012 Apr; 5(4):562-73. Vitale-Cross L, Molinolo AA, Martin D, Younis RH, Maruyama T, Patel V, Chen W, Schneider A, Gutkind JS. PMID: 22467081; PMCID: PMC3429367.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    227. Expression of heme oxygenase-1 in non-small cell lung cancer (NSCLC) and its correlation with clinical data. Lung Cancer. 2012 Jul; 77(1):168-75. Degese MS, Mendizabal JE, Gandini NA, Gutkind JS, Molinolo A, Hewitt SM, Curino AC, Coso OA, Facchinetti MM. PMID: 22418244; PMCID: PMC8381257.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    228. mTOR as a molecular target in HPV-associated oral and cervical squamous carcinomas. Clin Cancer Res. 2012 May 01; 18(9):2558-68. Molinolo AA, Marsh C, El Dinali M, Gangane N, Jennison K, Hewitt S, Patel V, Seiwert TY, Gutkind JS. PMID: 22409888; PMCID: PMC3443560.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    229. Estrogen receptor alpha mediates progestin-induced mammary tumor growth by interacting with progesterone receptors at the cyclin D1/MYC promoters. Cancer Res. 2012 May 01; 72(9):2416-27. Giulianelli S, Vaqué JP, Soldati R, Wargon V, Vanzulli SI, Martins R, Zeitlin E, Molinolo AA, Helguero LA, Lamb CA, Gutkind JS, Lanari C. PMID: 22396492.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    230. mTOR inhibitors and its role in the treatment of head and neck squamous cell carcinoma. Curr Treat Options Oncol. 2012 Mar; 13(1):71-81. Nguyen SA, Walker D, Gillespie MB, Gutkind JS, Day TA. PMID: 22282394.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    231. Future directions and treatment strategies for head and neck squamous cell carcinomas. Transl Res. 2012 Sep; 160(3):167-77. Wise-Draper TM, Draper DJ, Gutkind JS, Molinolo AA, Wikenheiser-Brokamp KA, Wells SI. PMID: 22683420; PMCID: PMC3423575.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    232. [The role of estrogen receptor alpha in breast cancer cell proliferation mediated by progestins]. Medicina (B Aires). 2012; 72(4):315-20. Giulianelli S, Vaqué JP, Wargon V, Soldati R, Vanzulli SI, Martins R, Zeitlin E, Helguero L, Lamb C, Molinolo AA, Gutkind JS, Lanari C. PMID: 22892083.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    233. Interleukin-21 expression and its association with proinflammatory cytokines in untreated chronic periodontitis patients. J Periodontol. 2012 Jul; 83(7):948-54. Dutzan N, Vernal R, Vaque JP, García-Sesnich J, Hernandez M, Abusleme L, Dezerega A, Gutkind JS, Gamonal J. PMID: 22181687.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCellsPHPublic Health
    234. Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer. Cell Res. 2012 Jan; 22(1):23-32. Sakurai A, Doçi CL, Doci C, Gutkind JS. PMID: 22157652; PMCID: PMC3351930.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    235. Accumulation of the SET protein in HEK293T cells and mild oxidative stress: cell survival or death signaling. Mol Cell Biochem. 2012 Apr; 363(1-2):65-74. Leopoldino AM, Squarize CH, Garcia CB, Almeida LO, Pestana CR, Polizello AC, Uyemura SA, Tajara EH, Gutkind JS, Curti C. PMID: 22143534.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    236. Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation. Oncogene. 2012 Jul 12; 31(28):3322-32. Bian Y, Hall B, Sun ZJ, Molinolo A, Chen W, Gutkind JS, Waes CV, Kulkarni AB. PMID: 22037217; PMCID: PMC3270146.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    237. Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer. Cancer Res. 2011 Nov 15; 71(22):7103-12. Patel V, Marsh CA, Dorsam RT, Mikelis CM, Masedunskas A, Amornphimoltham P, Nathan CA, Nathan CA, Singh B, Weigert R, Molinolo AA, Gutkind JS. PMID: 21975930; PMCID: PMC3443559.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimals
    238. Modulation of canonical Wnt signaling by the extracellular matrix component biglycan. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):17022-7. Berendsen AD, Fisher LW, Kilts TM, Owens RT, Robey PG, Gutkind JS, Young MF. PMID: 21969569; PMCID: PMC3193219.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    239. A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells. Sci Signal. 2011 Sep 20; 4(191):ra60. Yagi H, Tan W, Dillenburg-Pilla P, Armando S, Amornphimoltham P, Simaan M, Weigert R, Molinolo AA, Bouvier M, Gutkind JS. PMID: 21934106; PMCID: PMC3429372.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    240. Signaling circuitries controlling stem cell fate: to be or not to be. Curr Opin Cell Biol. 2011 Dec; 23(6):716-23. Iglesias-Bartolome R, Gutkind JS. PMID: 21880478; PMCID: PMC3391582.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    241. Phosphatidylinositol-4-phosphate 5-kinase and GEP100/Brag2 protein mediate antiangiogenic signaling by semaphorin 3E-plexin-D1 through Arf6 protein. J Biol Chem. 2011 Sep 30; 286(39):34335-45. Sakurai A, Jian X, Lee CJ, Manavski Y, Chavakis E, Donaldson J, Randazzo PA, Gutkind JS. PMID: 21795701; PMCID: PMC3190799.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    242. Combining portable Raman probes with nanotubes for theranostic applications. Theranostics. 2011; 1:310-21. Bhirde AA, Liu G, Jin A, Iglesias-Bartolome R, Sousa AA, Leapman RD, Gutkind JS, Lee S, Chen X. PMID: 21769298; PMCID: PMC3137983.
      View in: PubMed   Mentions: 12     Fields:    
    243. Nanostructured immunosensor for attomolar detection of cancer biomarker interleukin-8 using massively labeled superparamagnetic particles. Angew Chem Int Ed Engl. 2011 Aug 16; 50(34):7915-8. Munge BS, Coffey AL, Doucette JM, Somba BK, Malhotra R, Patel V, Gutkind JS, Rusling JF. PMID: 21721091; PMCID: PMC3315054.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    244. PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis. Cancer Cell. 2011 Jun 14; 19(6):805-13. Martin D, Galisteo R, Molinolo AA, Wetzker R, Hirsch E, Gutkind JS. PMID: 21665152; PMCID: PMC3170773.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    245. Microfluidic electrochemical immunoarray for ultrasensitive detection of two cancer biomarker proteins in serum. Biosens Bioelectron. 2011 Jul 15; 26(11):4477-83. Chikkaveeraiah BV, Mani V, Patel V, Gutkind JS, Rusling JF. PMID: 21632234; PMCID: PMC3120903.
      View in: PubMed   Mentions: 59     Fields:    Translation:Humans
    246. Interaction between FGFR-2, STAT5, and progesterone receptors in breast cancer. Cancer Res. 2011 May 15; 71(10):3720-31. Cerliani JP, Guillardoy T, Giulianelli S, Vaque JP, Gutkind JS, Vanzulli SI, Martins R, Zeitlin E, Lamb CA, Lanari C. PMID: 21464042.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    247. Assembly and patterning of the vascular network of the vertebrate hindbrain. Development. 2011 May; 138(9):1705-15. Fujita M, Cha YR, Pham VN, Sakurai A, Roman BL, Gutkind JS, Weinstein BM. PMID: 21429985; PMCID: PMC3074447.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    248. Integrin αβ1, αvβ, α6β effectors p130Cas, Src and talin regulate carcinoma invasion and chemoresistance. Biochem Biophys Res Commun. 2011 Mar 11; 406(2):171-6. Sansing HA, Sarkeshik A, Yates JR, Patel V, Gutkind JS, Yamada KM, Berrier AL. PMID: 21291860; PMCID: PMC3102534.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    249. c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase. Oncogene. 2011 Apr 28; 30(17):2003-16. Szabo R, Rasmussen AL, Moyer AB, Kosa P, Schafer JM, Molinolo AA, Gutkind JS, Bugge TH. PMID: 21217780; PMCID: PMC3084339.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    250. Nano delivers big: designing molecular missiles for cancer therapeutics. Pharmaceutics. 2011; 3(1):34-52. Patel S, Bhirde AA, Rusling JF, Chen X, Gutkind JS, Patel V. PMID: 21949900; PMCID: PMC3179248.
      View in: PubMed   Mentions: 13  
    251. Cellular systems for studying human oral squamous cell carcinomas. Adv Exp Med Biol. 2011; 720:27-38. Patel V, Iglesias-Bartolome R, Siegele B, Marsh CA, Leelahavanichkul K, Molinolo AA, Gutkind JS. PMID: 21901616.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    252. Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Mol Cell. 2010 Dec 22; 40(6):877-92. Sosa MS, Lopez-Haber C, Yang C, Wang H, Lemmon MA, Busillo JM, Luo J, Benovic JL, Klein-Szanto A, Yagi H, Gutkind JS, Parsons RE, Kazanietz MG. PMID: 21172654; PMCID: PMC3038344.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansCells
    253. Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3. Nat Immunol. 2011 Jan; 12(1):86-95. Maruyama T, Li J, Vaque JP, Konkel JE, Wang W, Zhang B, Zhang P, Zamarron BF, Yu D, Wu Y, Zhuang Y, Gutkind JS, Chen W. PMID: 21131965; PMCID: PMC3140164.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    254. Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice. Nanomedicine (Lond). 2010 Dec; 5(10):1535-46. Bhirde AA, Patel S, Sousa AA, Patel V, Molinolo AA, Ji Y, Leapman RD, Gutkind JS, Rusling JF. PMID: 21143032; PMCID: PMC3175610.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    255. Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6. Mol Cell Biol. 2011 Jan; 31(1):179-89. Cervenka I, Wolf J, Mašek J, Krejci P, Wilcox WR, Kozubík A, Schulte G, Gutkind JS, Bryja V. PMID: 20974802; PMCID: PMC3019858.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    256. A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation. Oral Oncol. 2010 Dec; 46(12):880-7. Abrahao AC, Castilho RM, Squarize CH, Molinolo AA, dos Santos-Pinto D, Gutkind JS. PMID: 20951077; PMCID: PMC2991505.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    257. MPA-induced gene expression and stromal and parenchymal gene expression profiles in luminal murine mammary carcinomas with different hormonal requirements. Breast Cancer Res Treat. 2011 Aug; 129(1):49-67. Giulianelli S, Herschkowitz JI, Patel V, Lamb CA, Gutkind JS, Molinolo A, Perou CM, Lanari C. PMID: 20890655.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    258. Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis. Science. 2010 Sep 24; 329(5999):1645-7. Knox SM, Lombaert IM, Reed X, Vitale-Cross L, Gutkind JS, Hoffman MP. PMID: 20929848; PMCID: PMC3376907.
      View in: PubMed   Mentions: 183     Fields:    Translation:AnimalsCells
    259. Remodeling of VE-cadherin junctions by the human herpes virus 8 G-protein coupled receptor. Oncogene. 2011 Jan 13; 30(2):190-200. Dwyer J, Le Guelte A, Galan Moya EM, Sumbal M, Carlotti A, Douguet L, Gutkind JS, Grange PA, Dupin N, Gavard J. PMID: 20818438.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    260. Keeping the epidermal stem cell niche in shape. Cell Stem Cell. 2010 Aug 06; 7(2):143-5. Iglesias-Bartolome R, Gutkind JS. PMID: 20682441.
      View in: PubMed   Mentions: 4     Fields:    
    261. Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer. Analyst. 2010 Oct; 135(10):2496-511. Rusling JF, Kumar CV, Gutkind JS, Patel V. PMID: 20614087; PMCID: PMC2997816.
      View in: PubMed   Mentions: 137     Fields:    Translation:Humans
    262. The expression of sphingosine kinase-1 in head and neck carcinoma. Cells Tissues Organs. 2010; 192(5):314-24. Facchinetti MM, Gandini NA, Fermento ME, Sterin-Speziale NB, Ji Y, Patel V, Gutkind JS, Rivadulla MG, Curino AC. PMID: 20606403; PMCID: PMC2974839.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    263. PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets. Proc Natl Acad Sci U S A. 2010 Jul 06; 107(27):12216-21. Hou X, Kumar A, Lee C, Wang B, Arjunan P, Dong L, Maminishkis A, Tang Z, Li Y, Zhang F, Zhang SZ, Wardega P, Chakrabarty S, Liu B, Wu Z, Colosi P, Fariss RN, Lennartsson J, Nussenblatt R, Gutkind JS, Cao Y, Li X. PMID: 20566880; PMCID: PMC2901428.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    264. Classical membrane progesterone receptors in murine mammary carcinomas: agonistic effects of progestins and RU-486 mediating rapid non-genomic effects. Breast Cancer Res Treat. 2011 Apr; 126(3):621-36. Bottino MC, Cerliani JP, Rojas P, Giulianelli S, Soldati R, Mondillo C, Gorostiaga MA, Pignataro OP, Calvo JC, Gutkind JS, Molinolo AA, Lüthy IA, Lanari C. PMID: 20535544.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    265. Accelerated wound healing by mTOR activation in genetically defined mouse models. PLoS One. 2010 May 13; 5(5):e10643. Squarize CH, Castilho RM, Bugge TH, Gutkind JS. PMID: 20498714; PMCID: PMC2869363.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    266. Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6. Nat Med. 2010 Jun; 16(6):662-4. Weller ML, Amornphimoltham P, Schmidt M, Wilson PA, Gutkind JS, Chiorini JA. PMID: 20473307; PMCID: PMC2885716.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    267. Rac1 is required for epithelial stem cell function during dermal and oral mucosal wound healing but not for tissue homeostasis in mice. PLoS One. 2010 May 06; 5(5):e10503. Castilho RM, Squarize CH, Leelahavanichkul K, Zheng Y, Bugge T, Gutkind JS. PMID: 20463891; PMCID: PMC2865533.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    268. Ultrasensitive electrochemical immunosensor for oral cancer biomarker IL-6 using carbon nanotube forest electrodes and multilabel amplification. Anal Chem. 2010 Apr 15; 82(8):3118-23. Malhotra R, Patel V, Vaqué JP, Gutkind JS, Rusling JF. PMID: 20192182; PMCID: PMC2854872.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    269. Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras. Mol Cell Biol. 2010 Jun; 30(12):3086-98. Sakurai A, Gavard J, Annas-Linhares Y, Basile JR, Amornphimoltham P, Palmby TR, Yagi H, Zhang F, Randazzo PA, Li X, Weigert R, Gutkind JS. PMID: 20385769; PMCID: PMC2876686.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    270. EPS8 upregulates FOXM1 expression, enhancing cell growth and motility. Carcinogenesis. 2010 Jun; 31(6):1132-41. Wang H, Teh MT, Ji Y, Patel V, Firouzabadian S, Patel AA, Gutkind JS, Yeudall WA. PMID: 20351091; PMCID: PMC2878363.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    271. Activation of Ras and Rho GTPases and MAP Kinases by G-protein-coupled receptors. Methods Mol Biol. 2010; 661:137-50. Chiariello M, Vaqué JP, Crespo P, Gutkind JS. PMID: 20811981.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    272. Meeting report--the NIDCR 2(nd) Salivary Gland Tumor Meeting, November 2008. Head Neck. 2009 Dec; 31(12):1542-3. El-Naggar AK, Kaye FJ, Shirazi Y, Gutkind JS, Forastiere AA. PMID: 19890918.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    273. 1 Alpha,25-dihydroxyvitamin D3 and its TX527 analog inhibit the growth of endothelial cells transformed by Kaposi sarcoma-associated herpes virus G protein-coupled receptor in vitro and in vivo. Endocrinology. 2010 Jan; 151(1):23-31. Gonzalez-Pardo V, Martin D, Gutkind JS, Verstuyf A, Bouillon R, de Boland AR, Boland RL. PMID: 19915163.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    274. Single-wall carbon nanotube forest arrays for immunoelectrochemical measurement of four protein biomarkers for prostate cancer. Anal Chem. 2009 Nov 01; 81(21):9129-34. Chikkaveeraiah BV, Bhirde A, Malhotra R, Patel V, Gutkind JS, Rusling JF. PMID: 19775154; PMCID: PMC2901508.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    275. Imaging the distribution of individual platinum-based anticancer drug molecules attached to single-wall carbon nanotubes. Nanomedicine (Lond). 2009 Oct; 4(7):763-72. Bhirde AA, Sousa AA, Patel V, Azari AA, Gutkind JS, Leapman RD, Rusling JF. PMID: 19839812; PMCID: PMC2789973.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    276. mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. Cell Stem Cell. 2009 Sep 04; 5(3):279-89. Castilho RM, Squarize CH, Chodosh LA, Williams BO, Gutkind JS. PMID: 19733540; PMCID: PMC2939833.
      View in: PubMed   Mentions: 215     Fields:    Translation:AnimalsCells
    277. Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway. Cancer Res. 2009 Jul 15; 69(14):5918-26. Bian Y, Terse A, Du J, Hall B, Molinolo A, Zhang P, Chen W, Flanders KC, Gutkind JS, Wakefield LM, Kulkarni AB. PMID: 19584284; PMCID: PMC2758611.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    278. Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model. Cancer Res. 2009 May 15; 69(10):4159-66. Raimondi AR, Molinolo A, Gutkind JS. PMID: 19435901.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimals
    279. How mitogen-activated protein kinases recognize and phosphorylate their targets: A QM/MM study. J Am Chem Soc. 2009 May 06; 131(17):6141-8. Turjanski AG, Hummer G, Gutkind JS. PMID: 19361221; PMCID: PMC2754815.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    280. Differential inhibitor of Gbetagamma signaling to AKT and ERK derived from phosducin-like protein: effect on sphingosine 1-phosphate-induced endothelial cell migration and in vitro angiogenesis. J Biol Chem. 2009 Jul 03; 284(27):18334-46. Guzmán-Hernández ML, Vázquez-Macías A, Carretero-Ortega J, Hernández-García R, García-Regalado A, Hernández-Negrete I, Reyes-Cruz G, Gutkind JS, Vázquez-Prado J. PMID: 19403526; PMCID: PMC2709366.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    281. Chemical carcinogenesis models for evaluating molecular-targeted prevention and treatment of oral cancer. Cancer Prev Res (Phila). 2009 May; 2(5):419-22. Vitale-Cross L, Czerninski R, Amornphimoltham P, Patel V, Molinolo AA, Gutkind JS. PMID: 19401522.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    282. Ultrasensitive immunosensor for cancer biomarker proteins using gold nanoparticle film electrodes and multienzyme-particle amplification. ACS Nano. 2009 Mar 24; 3(3):585-94. Mani V, Chikkaveeraiah BV, Patel V, Gutkind JS, Rusling JF. PMID: 19216571; PMCID: PMC2666939.
      View in: PubMed   Mentions: 79     Fields:    Translation:Humans
    283. A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability. Mol Cell Biol. 2009 May; 29(9):2469-80. Gavard J, Hou X, Qu Y, Masedunskas A, Martin D, Weigert R, Li X, Gutkind JS. PMID: 19255141; PMCID: PMC2668372.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    284. Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. ACS Nano. 2009 Feb 24; 3(2):307-16. Bhirde AA, Patel V, Gavard J, Zhang G, Sousa AA, Masedunskas A, Leapman RD, Weigert R, Gutkind JS, Rusling JF. PMID: 19236065; PMCID: PMC2665730.
      View in: PubMed   Mentions: 150     Fields:    Translation:HumansAnimalsCells
    285. The beta-catenin axis integrates multiple signals downstream from RET/papillary thyroid carcinoma leading to cell proliferation. Cancer Res. 2009 Mar 01; 69(5):1867-76. Castellone MD, De Falco V, Rao DM, Bellelli R, Muthu M, Basolo F, Fusco A, Gutkind JS, Santoro M. PMID: 19223551; PMCID: PMC2746012.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    286. A new G(q)-initiated MAPK signaling pathway in the heart. Dev Cell. 2009 Feb; 16(2):163-4. Gutkind JS, Offermanns S. PMID: 19217418.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    287. Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure. Oral Oncol. 2009 Aug; 45(8):712-9. Cheong SC, Chandramouli GV, Saleh A, Zain RB, Lau SH, Sivakumaren S, Pathmanathan R, Prime SS, Teo SH, Patel V, Gutkind JS. PMID: 19147396.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    288. Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model. Cancer Prev Res (Phila). 2009 Jan; 2(1):27-36. Czerninski R, Amornphimoltham P, Patel V, Molinolo AA, Gutkind JS. PMID: 19139015.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    289. Kaposi's sarcoma virally encoded, G-protein-coupled receptor: a paradigm for paracrine transformation. Methods Enzymol. 2009; 460:125-50. Martin D, Gutkind JS. PMID: 19446723.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    290. Electrochemical Immunosensors for Interleukin-6. Comparison of Carbon Nanotube Forest and Gold Nanoparticle platforms. Electrochem commun. 2009; 11(5):1009-1012. Munge BS, Krause CE, Malhotra R, Patel V, Gutkind JS, Rusling JF. PMID: 20046945; PMCID: PMC2735272.
      View in: PubMed   Mentions: 30  
    291. CXCL8/IL8 stimulates vascular endothelial growth factor (VEGF) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM (Carma3/Bcl10/Malt1) complex. J Biol Chem. 2009 Mar 06; 284(10):6038-42. Martin D, Galisteo R, Gutkind JS. PMID: 19112107; PMCID: PMC2649103.
      View in: PubMed   Mentions: 190     Fields:    Translation:HumansAnimalsCells
    292. Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/AKT-dependent activation of myocyte enhancer factor 2. J Biol Chem. 2009 Feb 27; 284(9):5592-601. Sako K, Fukuhara S, Minami T, Hamakubo T, Song H, Kodama T, Fukamizu A, Gutkind JS, Koh GY, Mochizuki N. PMID: 19106103.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    293. Inhibition of Mammalian target of rapamycin by rapamycin causes the regression of carcinogen-induced skin tumor lesions. Clin Cancer Res. 2008 Dec 15; 14(24):8094-101. Amornphimoltham P, Leelahavanichkul K, Molinolo A, Patel V, Gutkind JS. PMID: 19073969; PMCID: PMC3407681.
      View in: PubMed   Mentions: 41     Fields:    Translation:Animals
    294. Human tumor-associated viruses and new insights into the molecular mechanisms of cancer. Oncogene. 2008 Dec; 27 Suppl 2:S31-42. Martin D, Gutkind JS. PMID: 19956178.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    295. Role for EPS8 in squamous carcinogenesis. Carcinogenesis. 2009 Jan; 30(1):165-74. Wang H, Patel V, Miyazaki H, Gutkind JS, Yeudall WA. PMID: 19008210.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    296. Hypoxia-induced energy stress inhibits the mTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma. Neoplasia. 2008 Nov; 10(11):1295-302. Schneider A, Younis RH, Gutkind JS. PMID: 18953439; PMCID: PMC2570606.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    297. Dysregulated molecular networks in head and neck carcinogenesis. Oral Oncol. 2009 Apr-May; 45(4-5):324-34. Molinolo AA, Amornphimoltham P, Squarize CH, Castilho RM, Patel V, Gutkind JS. PMID: 18805044; PMCID: PMC2743485.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansCells
    298. Keratin down-regulation in vimentin-positive cancer cells is reversible by vimentin RNA interference, which inhibits growth and motility. Mol Cancer Ther. 2008 Sep; 7(9):2894-903. Paccione RJ, Miyazaki H, Patel V, Waseem A, Gutkind JS, Zehner ZE, Yeudall WA. PMID: 18790770.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    299. Chemoprevention and treatment of experimental Cowden's disease by mTOR inhibition with rapamycin. Cancer Res. 2008 Sep 01; 68(17):7066-72. Squarize CH, Castilho RM, Gutkind JS. PMID: 18757421.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    300. Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha12/13 and Galpha11/q. J Biol Chem. 2008 Oct 31; 283(44):29888-96. Gavard J, Gutkind JS. PMID: 18713748; PMCID: PMC2573073.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    301. VE-cadherin and claudin-5: it takes two to tango. Nat Cell Biol. 2008 Aug; 10(8):883-5. Gavard J, Gutkind JS. PMID: 18670447; PMCID: PMC2666287.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    302. Snail up-regulates proinflammatory mediators and inhibits differentiation in oral keratinocytes. Cancer Res. 2008 Jun 15; 68(12):4525-30. Lyons JG, Patel V, Roue NC, Fok SY, Soon LL, Halliday GM, Gutkind JS. PMID: 18559496; PMCID: PMC2631428.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    303. RCAS/SCL-TVA animal model allows targeted delivery of polyoma middle T oncogene to vascular endothelial progenitors in vivo and results in hemangioma development. Clin Cancer Res. 2008 Jun 15; 14(12):3948-55. Sausville J, Molinolo AA, Cheng X, Frampton J, Takebe N, Gutkind JS, Feldman RA. PMID: 18559617.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    304. TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation. Oncogene. 2008 Sep 11; 27(40):5348-53. Sun C, Dobi A, Mohamed A, Li H, Thangapazham RL, Furusato B, Shaheduzzaman S, Tan SH, Vaidyanathan G, Whitman E, Hawksworth DJ, Chen Y, Nau M, Patel V, Vahey M, Gutkind JS, Sreenath T, Petrovics G, Sesterhenn IA, McLeod DG, Srivastava S. PMID: 18542058; PMCID: PMC7556723.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    305. Binding-induced folding of a natively unstructured transcription factor. PLoS Comput Biol. 2008 Apr 11; 4(4):e1000060. Turjanski AG, Gutkind JS, Best RB, Hummer G. PMID: 18404207; PMCID: PMC2289845.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    306. Proteomic analysis of laser-captured paraffin-embedded tissues: a molecular portrait of head and neck cancer progression. Clin Cancer Res. 2008 Feb 15; 14(4):1002-14. Patel V, Hood BL, Molinolo AA, Lee NH, Conrads TP, Braisted JC, Krizman DB, Veenstra TD, Gutkind JS. PMID: 18281532.
      View in: PubMed   Mentions: 77     Fields:    Translation:Humans
    307. A retroinhibition approach reveals a tumor cell-autonomous response to rapamycin in head and neck cancer. Cancer Res. 2008 Feb 15; 68(4):1144-53. Amornphimoltham P, Patel V, Leelahavanichkul K, Abraham RT, Gutkind JS. PMID: 18281490; PMCID: PMC3443567.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    308. An essential role for Rac1 in endothelial cell function and vascular development. FASEB J. 2008 Jun; 22(6):1829-38. Tan W, Palmby TR, Gavard J, Amornphimoltham P, Zheng Y, Gutkind JS. PMID: 18245172.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    309. Reciprocal negative regulation between S100A7/psoriasin and beta-catenin signaling plays an important role in tumor progression of squamous cell carcinoma of oral cavity. Oncogene. 2008 Jun 05; 27(25):3527-38. Zhou G, Xie TX, Zhao M, Jasser SA, Younes MN, Sano D, Lin J, Kupferman ME, Santillan AA, Patel V, Gutkind JS, Ei-Naggar AK, Emberley ED, Watson PH, Matsuzawa SI, Reed JC, Myers JN. PMID: 18223693.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    310. Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia. Dev Cell. 2008 Jan; 14(1):25-36. Gavard J, Patel V, Gutkind JS. PMID: 18194650.
      View in: PubMed   Mentions: 201     Fields:    Translation:HumansCells
    311. Multiple PPPS/TP motifs act in a combinatorial fashion to transduce Wnt signaling through LRP6. FEBS Lett. 2008 Jan 23; 582(2):255-61. Wolf J, Palmby TR, Gavard J, Williams BO, Gutkind JS. PMID: 18083125; PMCID: PMC2268019.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    312. G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension. Nat Med. 2008 Jan; 14(1):64-8. Wirth A, Benyó Z, Lukasova M, Leutgeb B, Wettschureck N, Gorbey S, Orsy P, Horváth B, Maser-Gluth C, Greiner E, Lemmer B, Schütz G, Gutkind JS, Offermanns S. PMID: 18084302.
      View in: PubMed   Mentions: 369     Fields:    Translation:AnimalsCells
    313. Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature. J Biol Chem. 2008 Jan 04; 283(1):529-540. Liu S, Wang H, Currie BM, Molinolo A, Leung HJ, Moayeri M, Basile JR, Alfano RW, Gutkind JS, Frankel AE, Bugge TH, Leppla SH. PMID: 17974567; PMCID: PMC2394502.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    314. An NF-kappaB gene expression signature contributes to Kaposi's sarcoma virus vGPCR-induced direct and paracrine neoplasia. Oncogene. 2008 Mar 20; 27(13):1844-52. Martin D, Galisteo R, Ji Y, Montaner S, Gutkind JS. PMID: 17934524.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    315. The Galpha12/13 family of heterotrimeric G proteins and the small GTPase RhoA link the Kaposi sarcoma-associated herpes virus G protein-coupled receptor to heme oxygenase-1 expression and tumorigenesis. J Biol Chem. 2007 Nov 23; 282(47):34510-24. Martín MJ, Tanos T, García AB, Martin D, Gutkind JS, Coso OA, Marinissen MJ. PMID: 17881360.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    316. Plexin-B1 utilizes RhoA and Rho kinase to promote the integrin-dependent activation of Akt and ERK and endothelial cell motility. J Biol Chem. 2007 Nov 30; 282(48):34888-95. Basile JR, Gavard J, Gutkind JS. PMID: 17855350.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    317. Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative. Clin Cancer Res. 2007 Sep 01; 13(17):4964-73. Molinolo AA, Hewitt SM, Amornphimoltham P, Keelawat S, Rangdaeng S, Meneses García A, Raimondi AR, Jufe R, Itoiz M, Gao Y, Saranath D, Kaleebi GS, Yoo GH, Leak L, Myers EM, Shintani S, Wong D, Massey HD, Yeudall WA, Lonardo F, Ensley J, Gutkind JS. PMID: 17785546.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansCells
    318. Augmented Wnt signaling in a mammalian model of accelerated aging. Science. 2007 Aug 10; 317(5839):803-6. Liu H, Fergusson MM, Castilho RM, Liu J, Cao L, Chen J, Malide D, Rovira II, Schimel D, Kuo CJ, Gutkind JS, Hwang PM, Finkel T. PMID: 17690294.
      View in: PubMed   Mentions: 391     Fields:    Translation:HumansAnimalsCells
    319. Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons. Mol Biol Cell. 2007 Sep; 18(9):3645-55. Kesavapany S, Patel V, Zheng YL, Pareek TK, Bjelogrlic M, Albers W, Amin N, Jaffe H, Gutkind JS, Strong MJ, Grant P, Pant HC. PMID: 17626162; PMCID: PMC1951754.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    320. Complementary roles of intracellular and pericellular collagen degradation pathways in vivo. Mol Cell Biol. 2007 Sep; 27(18):6309-22. Wagenaar-Miller RA, Engelholm LH, Gavard J, Yamada SS, Gutkind JS, Behrendt N, Bugge TH, Holmbeck K. PMID: 17620416; PMCID: PMC2099620.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    321. P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration. J Biol Chem. 2007 Aug 10; 282(32):23708-15. Hernández-Negrete I, Carretero-Ortega J, Rosenfeldt H, Hernández-García R, Calderón-Salinas JV, Reyes-Cruz G, Gutkind JS, Vázquez-Prado J. PMID: 17565979.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    322. TGF-beta receptor I conditional knockout mice develop spontaneous squamous cell carcinoma. Cell Cycle. 2007 Jun 01; 6(11):1360-6. Honjo Y, Bian Y, Kawakami K, Molinolo A, Longenecker G, Boppana R, Larsson J, Karlsson S, Gutkind JS, Puri RK, Kulkarni AB. PMID: 17534148.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    323. MAP kinases and the control of nuclear events. Oncogene. 2007 May 14; 26(22):3240-53. Turjanski AG, Vaqué JP, Gutkind JS. PMID: 17496919.
      View in: PubMed   Mentions: 188     Fields:    Translation:HumansAnimalsCells
    324. Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells. Oncogene. 2007 Aug 02; 26(35):5078-85. Castilho RM, Squarize CH, Patel V, Millar SE, Zheng Y, Molinolo A, Gutkind JS. PMID: 17334398.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    325. Diverse activation states of RhoA in human lung cancer cells: contribution of G protein coupled receptors. Int J Oncol. 2007 Mar; 30(3):709-15. Touge H, Chikumi H, Igishi T, Kurai J, Makino H, Tamura Y, Takata M, Yoneda K, Nakamoto M, Suyama H, Gutkind JS, Shimizu E. PMID: 17273773.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    326. G-protein-coupled receptors and cancer. Nat Rev Cancer. 2007 Feb; 7(2):79-94. Dorsam RT, Gutkind JS. PMID: 17251915.
      View in: PubMed   Mentions: 649     Fields:    Translation:HumansCells
    327. [VE-cadherin takes a walk on the wild side]. Med Sci (Paris). 2007 Feb; 23(2):119-21. Gavard J, Gutkind JS. PMID: 17291415.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    328. Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion. Carcinogenesis. 2007 Jun; 28(6):1145-52. Patel V, Rosenfeldt HM, Lyons R, Servitja JM, Bustelo XR, Siroff M, Gutkind JS. PMID: 17234718.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    329. MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D. J Biol Chem. 2007 Mar 02; 282(9):6899-905. Basile JR, Holmbeck K, Bugge TH, Gutkind JS. PMID: 17204469.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    330. Rac inhibits thrombin-induced Rho activation: evidence of a Pak-dependent GTPase crosstalk. J Mol Signal. 2006 Dec 06; 1:8. Rosenfeldt H, Castellone MD, Randazzo PA, Gutkind JS. PMID: 17224083; PMCID: PMC1769496.
      View in: PubMed   Mentions: 30  
    331. Cyclooxygenase-2 and colorectal cancer chemoprevention: the beta-catenin connection. Cancer Res. 2006 Dec 01; 66(23):11085-8. Castellone MD, Teramoto H, Gutkind JS. PMID: 17145847.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    332. VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin. Nat Cell Biol. 2006 Nov; 8(11):1223-34. Gavard J, Gutkind JS. PMID: 17060906.
      View in: PubMed   Mentions: 462     Fields:    Translation:HumansCells
    333. The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4. J Biol Chem. 2006 Dec 22; 281(51):39542-9. Tan W, Martin D, Gutkind JS. PMID: 17056591.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    334. Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma. Neoplasia. 2006 Sep; 8(9):733-46. Squarize CH, Castilho RM, Sriuranpong V, Pinto DS, Gutkind JS. PMID: 16984731; PMCID: PMC1584297.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    335. Carbon nanotube amplification strategies for highly sensitive immunodetection of cancer biomarkers. J Am Chem Soc. 2006 Aug 30; 128(34):11199-205. Yu X, Munge B, Patel V, Jensen G, Bhirde A, Gong JD, Kim SN, Gillespie J, Gutkind JS, Papadimitrakopoulos F, Rusling JF. PMID: 16925438; PMCID: PMC2482602.
      View in: PubMed   Mentions: 88     Fields:    Translation:Humans
    336. Neuronal nuclear organization is controlled by cyclin-dependent kinase 5 phosphorylation of Ras Guanine nucleotide releasing factor-1. Neurosignals. 2006-2007; 15(4):157-73. Kesavapany S, Pareek TK, Zheng YL, Amin N, Gutkind JS, Ma W, Kulkarni AB, Grant P, Pant HC. PMID: 16921254.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    337. Gene expression changes in a patient presenting nonleukaemic nasal granulocytic sarcoma to acute myelogenous leukaemia using 40 K cDNA microarray. Clin Lab Haematol. 2006 Aug; 28(4):262-6. Teramoto H, Miwa H, Patel V, Letwin N, Castellone MD, Imai N, Shikami M, Imamura A, Gutkind JS, Nitta M, Lee NH. PMID: 16898967.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    338. The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. Cancer Cell. 2006 Aug; 10(2):133-43. Sodhi A, Chaisuparat R, Hu J, Ramsdell AK, Manning BD, Sausville EA, Sawai ET, Molinolo A, Gutkind JS, Montaner S. PMID: 16904612.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    339. A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans. Cancer. 2006 Jun 15; 106(12):2716-24. Gu J, Wu X, Dong Q, Romeo MJ, Lin X, Gutkind JS, Berman DM. PMID: 16691626.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    340. Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9017-22. Basile JR, Castilho RM, Williams VP, Gutkind JS. PMID: 16754882; PMCID: PMC1482558.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    341. Rapid development of salivary gland carcinomas upon conditional expression of K-ras driven by the cytokeratin 5 promoter. Am J Pathol. 2006 May; 168(5):1654-65. Raimondi AR, Vitale-Cross L, Amornphimoltham P, Gutkind JS, Molinolo A. PMID: 16651631; PMCID: PMC1606594.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    342. Down-regulation of CXCL5 inhibits squamous carcinogenesis. Cancer Res. 2006 Apr 15; 66(8):4279-84. Miyazaki H, Patel V, Wang H, Edmunds RK, Gutkind JS, Yeudall WA. PMID: 16618752.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    343. Combination chemotherapy and radiation of human squamous cell carcinoma of the head and neck augments CTL-mediated lysis. Clin Cancer Res. 2006 Mar 15; 12(6):1897-905. Gelbard A, Garnett CT, Abrams SI, Patel V, Gutkind JS, Palena C, Tsang KY, Schlom J, Hodge JW. PMID: 16551875; PMCID: PMC1865094.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    344. Inhibition of basic leucine zipper transcription is a major mediator of atrial dilatation. Cardiovasc Res. 2006 Jun 01; 70(3):543-54. Kehat I, Heinrich R, Ben-Izhak O, Miyazaki H, Gutkind JS, Aronheim A. PMID: 16631626.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    345. Robo4 signaling in endothelial cells implies attraction guidance mechanisms. J Biol Chem. 2006 Apr 21; 281(16):11347-56. Kaur S, Castellone MD, Bedell VM, Konar M, Gutkind JS, Ramchandran R. PMID: 16481322.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    346. The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor as a therapeutic target for the treatment of Kaposi's sarcoma. Cancer Res. 2006 Jan 01; 66(1):168-74. Montaner S, Sodhi A, Ramsdell AK, Martin D, Hu J, Sawai ET, Gutkind JS. PMID: 16397229.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    347. Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science. 2005 Dec 02; 310(5753):1504-10. Castellone MD, Teramoto H, Williams BO, Druey KM, Gutkind JS. PMID: 16293724.
      View in: PubMed   Mentions: 393     Fields:    Translation:HumansCells
    348. Growth factor-sensitive molecular targets identified in primary and metastatic head and neck squamous cell carcinoma using microarray analysis. Oral Oncol. 2006 Mar; 42(3):240-56. Miyazaki H, Patel V, Wang H, Ensley JF, Gutkind JS, Yeudall WA. PMID: 16266819.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    349. Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck. Cancer Res. 2005 Nov 01; 65(21):9953-61. Amornphimoltham P, Patel V, Sodhi A, Nikitakis NG, Sauk JJ, Sausville EA, Molinolo AA, Gutkind JS. PMID: 16267020.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    350. Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1. J Biol Chem. 2005 Oct 21; 280(42):35081-4. Monje P, Hernández-Losa J, Lyons RJ, Castellone MD, Gutkind JS. PMID: 16123044.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    351. Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation. Genes Dev. 2005 Aug 15; 19(16):1934-50. List K, Szabo R, Molinolo A, Sriuranpong V, Redeye V, Murdock T, Burke B, Nielsen BS, Gutkind JS, Bugge TH. PMID: 16103220; PMCID: PMC1186192.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimals
    352. Uncoupling of epidermal growth factor-dependent proliferation and invasion in a model of squamous carcinoma progression. Oral Oncol. 2005 Aug; 41(7):698-708. Yeudall WA, Miyazaki H, Ensley JF, Cardinali M, Gutkind JS, Patel V. PMID: 15935723.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    353. Scaffold proteins dictate Rho GTPase-signaling specificity. Trends Biochem Sci. 2005 Aug; 30(8):423-6. Marinissen MJ, Gutkind JS. PMID: 15996870.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    354. Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway. Mol Cell Biol. 2005 Aug; 25(16):6889-98. Basile JR, Afkhami T, Gutkind JS. PMID: 16055703; PMCID: PMC1190270.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    355. Profiling EGFR activity in head and neck squamous cell carcinoma by using a novel layered membrane Western blot technology. Oral Oncol. 2005 May; 41(5):503-8. Patel V, Ramesh A, Traicoff JL, Baibakov G, Emmert-Buck MR, Gutkind JS, Knezevic V. PMID: 15878755.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    356. The biology of tobacco and nicotine: bench to bedside. Cancer Epidemiol Biomarkers Prev. 2005 Apr; 14(4):764-7. Dennis PA, Van Waes C, Gutkind JS, Kellar KJ, Vinson C, Mukhin AG, Spitz MR, Bailey-Wilson JE, Yeh GC, Anderson LM, Wiest JS. PMID: 15824140; PMCID: PMC3459058.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    357. Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light. J Biol Chem. 2005 May 13; 280(19):18842-52. Tanos T, Marinissen MJ, Leskow FC, Hochbaum D, Martinetto H, Gutkind JS, Coso OA. PMID: 15708845.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    358. Proteome-wide analysis of head and neck squamous cell carcinomas using laser-capture microdissection and tandem mass spectrometry. Oral Oncol. 2005 Feb; 41(2):183-99. Baker H, Patel V, Molinolo AA, Shillitoe EJ, Ensley JF, Yoo GH, Meneses-García A, Myers JN, El-Naggar AK, Gutkind JS, Hancock WS. PMID: 15695121.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    359. The antitumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces NF-kappaB activity in drug-sensitive MCF-7 cells. Anticancer Drugs. 2005 Feb; 16(2):137-43. Brantley E, Patel V, Stinson SF, Trapani V, Hose CD, Ciolino HP, Yeh GC, Gutkind JS, Sausville EA, Loaiza-Pérez AI. PMID: 15655410.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    360. Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12. Oncogene. 2005 Jan 13; 24(3):489-501. Teramoto H, Castellone MD, Malek RL, Letwin N, Frank B, Gutkind JS, Lee NH. PMID: 15516973.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    361. Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis. Cancer Res. 2004 Dec 15; 64(24):8804-7. Vitale-Cross L, Amornphimoltham P, Fisher G, Molinolo AA, Gutkind JS. PMID: 15604235.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    362. Viral hijacking of G-protein-coupled-receptor signalling networks. Nat Rev Mol Cell Biol. 2004 Dec; 5(12):998-1012. Sodhi A, Montaner S, Gutkind JS. PMID: 15573137.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    363. Detection of plasminogen activators in oral cancer by laser capture microdissection combined with zymography. Oral Oncol. 2004 Nov; 40(10):1026-32. Curino A, Patel V, Nielsen BS, Iskander AJ, Ensley JF, Yoo GH, Holsinger FC, Myers JN, El-Nagaar A, Kellman RM, Shillitoe EJ, Molinolo AA, Gutkind JS, Bugge TH. PMID: 15509494.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    364. Global gene expression profiles of human head and neck squamous carcinoma cell lines. Int J Cancer. 2004 Nov 01; 112(2):249-58. Jeon GA, Lee JS, Patel V, Gutkind JS, Thorgeirsson SS, Kim EC, Chu IS, Amornphimoltham P, Park MH. PMID: 15352037.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    365. Chimeric G alpha i2/G alpha 13 proteins reveal the structural requirements for the binding and activation of the RGS-like (RGL)-containing Rho guanine nucleotide exchange factors (GEFs) by G alpha 13. J Biol Chem. 2004 Dec 24; 279(52):54283-90. Vázquez-Prado J, Miyazaki H, Castellone MD, Teramoto H, Gutkind JS. PMID: 15485891.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    366. P-REX2, a novel PI-3-kinase sensitive Rac exchange factor. FEBS Lett. 2004 Aug 13; 572(1-3):167-71. Rosenfeldt H, Vázquez-Prado J, Gutkind JS. PMID: 15304342.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    367. Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B. Cancer Res. 2004 Aug 01; 64(15):5212-24. Basile JR, Barac A, Zhu T, Guan KL, Gutkind JS. PMID: 15289326.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansCells
    368. Global gene expression profile of nasopharyngeal carcinoma by laser capture microdissection and complementary DNA microarrays. Clin Cancer Res. 2004 Aug 01; 10(15):4944-58. Sriuranpong V, Mutirangura A, Gillespie JW, Patel V, Amornphimoltham P, Molinolo AA, Kerekhanjanarong V, Supanakorn S, Supiyaphun P, Rangdaeng S, Voravud N, Gutkind JS. PMID: 15297395.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    369. The small GTPase Rac1 links the Kaposi sarcoma-associated herpesvirus vGPCR to cytokine secretion and paracrine neoplasia. Blood. 2004 Nov 01; 104(9):2903-11. Montaner S, Sodhi A, Servitja JM, Ramsdell AK, Barac A, Sawai ET, Gutkind JS. PMID: 15231571.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    370. Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01. Clin Cancer Res. 2004 Jun 15; 10(12 Pt 1):4029-37. Amornphimoltham P, Sriuranpong V, Patel V, Benavides F, Conti CJ, Sauk J, Sausville EA, Molinolo AA, Gutkind JS. PMID: 15217935.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    371. The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras. J Biol Chem. 2004 Aug 06; 279(32):33480-91. Oliva JL, Zarich N, Martínez N, Jorge R, Castrillo A, Azañedo M, García-Vargas S, Gutiérrez-Eisman S, Juarranz A, Boscá L, Gutkind JS, Rojas JM. PMID: 15181015.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    372. p35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent Extracellular Signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neurons. J Neurosci. 2004 May 05; 24(18):4421-31. Kesavapany S, Amin N, Zheng YL, Nijhara R, Jaffe H, Sihag R, Gutkind JS, Takahashi S, Kulkarni A, Grant P, Pant HC. PMID: 15128856; PMCID: PMC6729444.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    373. The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis. Mol Cell. 2004 Apr 09; 14(1):29-41. Marinissen MJ, Chiariello M, Tanos T, Bernard O, Narumiya S, Gutkind JS. PMID: 15068801.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    374. Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor. Proc Natl Acad Sci U S A. 2004 Apr 06; 101(14):4821-6. Sodhi A, Montaner S, Patel V, Gómez-Román JJ, Li Y, Sausville EA, Sawai ET, Gutkind JS. PMID: 15047889; PMCID: PMC387332.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    375. Does dysregulated expression of a deregulated viral GPCR trigger Kaposi's sarcomagenesis? FASEB J. 2004 Mar; 18(3):422-7. Sodhi A, Montaner S, Gutkind JS. PMID: 15003988.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    376. Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential. Oncogene. 2004 Jan 08; 23(1):233-40. Chikumi H, Barac A, Behbahani B, Gao Y, Teramoto H, Zheng Y, Gutkind JS. PMID: 14712228.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    377. Activation of MAPKs by G protein-coupled receptors. Methods Mol Biol. 2004; 250:203-10. Crespo P, Gutkind JS. PMID: 14755090.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    378. Modular architecture and novel protein-protein interactions regulating the RGS-containing Rho guanine nucleotide exchange factors. Methods Enzymol. 2004; 390:259-85. Vázquez-Prado J, Basile J, Gutkind JS. PMID: 15488183.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    379. Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor. J Biol Chem. 2004 Feb 13; 279(7):6182-9. Barac A, Basile J, Vázquez-Prado J, Gao Y, Zheng Y, Gutkind JS. PMID: 14625312.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    380. Enhancement of cisplatin-induced cytotoxicity by ROCK inhibitor through suppression of focal adhesion kinase-independent mechanism in lung carcinoma cells. Int J Oncol. 2003 Oct; 23(4):1079-85. Igishi T, Mikami M, Murakami K, Matsumoto S, Shigeoka Y, Nakanishi H, Yasuda K, Gutkind JS, Hitsuda Y, Shimizu E. PMID: 12963988.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    381. Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor. Mol Cell Biol. 2003 Oct; 23(19):7030-43. Monje P, Marinissen MJ, Gutkind JS. PMID: 12972619; PMCID: PMC193921.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    382. The platelet-derived growth factor controls c-myc expression through a JNK- and AP-1-dependent signaling pathway. J Biol Chem. 2003 Dec 12; 278(50):50024-30. Iavarone C, Catania A, Marinissen MJ, Visconti R, Acunzo M, Tarantino C, Carlomagno MS, Bruni CB, Gutkind JS, Chiariello M. PMID: 14523011.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    383. Thrombin protease-activated receptor-1 signals through Gq- and G13-initiated MAPK cascades regulating c-Jun expression to induce cell transformation. J Biol Chem. 2003 Nov 21; 278(47):46814-25. Marinissen MJ, Servitja JM, Offermanns S, Simon MI, Gutkind JS. PMID: 12954641.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    384. Laser capture microdissection-based in vivo genomic profiling of wound keratinocytes identifies similarities and differences to squamous cell carcinoma. Oncogene. 2003 Jun 19; 22(25):3964-76. Pedersen TX, Leethanakul C, Patel V, Mitola D, Lund LR, Danø K, Johnsen M, Gutkind JS, Bugge TH. PMID: 12813470.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    385. Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src. J Biol Chem. 2003 Sep 05; 278(36):34339-46. Servitja JM, Marinissen MJ, Sodhi A, Bustelo XR, Gutkind JS. PMID: 12810717.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    386. Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. Cancer Res. 2003 Jun 01; 63(11):2948-56. Sriuranpong V, Park JI, Amornphimoltham P, Patel V, Nelkin BD, Gutkind JS. PMID: 12782602.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansCells
    387. Identification of H-Ras, RhoA, Rac1 and Cdc42 responsive genes. Oncogene. 2003 May 01; 22(17):2689-97. Teramoto H, Malek RL, Behbahani B, Castellone MD, Lee NH, Gutkind JS. PMID: 12730683.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    388. Gene discovery in oral squamous cell carcinoma through the Head and Neck Cancer Genome Anatomy Project: confirmation by microarray analysis. Oral Oncol. 2003 Apr; 39(3):248-58. Leethanakul C, Knezevic V, Patel V, Amornphimoltham P, Gillespie J, Shillitoe EJ, Emko P, Park MH, Emmert-Buck MR, Strausberg RL, Krizman DB, Gutkind JS, Head and Neck Cancer Genome Anatomy Project. PMID: 12618197.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    389. Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase. J Biol Chem. 2003 Apr 11; 278(15):13520-30. Nishigaki K, Thompson D, Yugawa T, Rulli K, Hanson C, Cmarik J, Gutkind JS, Teramoto H, Ruscetti S. PMID: 12574163.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    390. Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway. Neuropharmacology. 2003 Feb; 44(2):171-80. Servitja JM, Masgrau R, Pardo R, Sarri E, von Eichel-Streiber C, Gutkind JS, Picatoste F. PMID: 12623215.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    391. Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Cancer Cell. 2003 Jan; 3(1):23-36. Montaner S, Sodhi A, Molinolo A, Bugge TH, Sawai ET, He Y, Li Y, Ray PE, Gutkind JS. PMID: 12559173.
      View in: PubMed   Mentions: 156     Fields:    Translation:AnimalsCells
    392. Antitumor activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27(KIP1). Clin Cancer Res. 2002 Nov; 8(11):3549-60. Patel V, Lahusen T, Leethanakul C, Igishi T, Kremer M, Quintanilla-Martinez L, Ensley JF, Sausville EA, Gutkind JS, Senderowicz AM. PMID: 12429646.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    393. Direct transmembrane clustering and cytoplasmic dimerization of focal adhesion kinase initiates its tyrosine phosphorylation. Biochim Biophys Acta. 2002 Oct 21; 1592(2):141-52. Katz BZ, Miyamoto S, Teramoto H, Zohar M, Krylov D, Vinson C, Gutkind JS, Yamada KM. PMID: 12379477.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    394. Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor. J Biol Chem. 2002 Dec 13; 277(50):48755-63. Guo YS, Cheng JZ, Jin GF, Gutkind JS, Hellmich MR, Townsend CM. PMID: 12239223.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    395. The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG. Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19):12085-90. Aurandt J, Vikis HG, Gutkind JS, Ahn N, Guan KL. PMID: 12196628; PMCID: PMC129402.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    396. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. J Biol Chem. 2002 Nov 08; 277(45):43115-20. Perrot V, Vazquez-Prado J, Gutkind JS. PMID: 12183458.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    397. PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells. Oncogene. 2002 Aug 08; 21(34):5289-300. Choi Y, Zhang J, Murga C, Yu H, Koller E, Monia BP, Gutkind JS, Li W. PMID: 12149650.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    398. Laminin-gamma2 overexpression in head-and-neck squamous cell carcinoma. Int J Cancer. 2002 Jun 01; 99(4):583-8. Patel V, Aldridge K, Ensley JF, Odell E, Boyd A, Jones J, Gutkind JS, Yeudall WA. PMID: 11992550.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    399. Potent activation of RhoA by Galpha q and Gq-coupled receptors. J Biol Chem. 2002 Jul 26; 277(30):27130-4. Chikumi H, Vázquez-Prado J, Servitja JM, Miyazaki H, Gutkind JS. PMID: 12016230.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    400. E-cadherin and Hakai: signalling, remodeling or destruction? Nat Cell Biol. 2002 Apr; 4(4):E72-4. Pece S, Gutkind JS. PMID: 11944035.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    401. CKA, a novel multidomain protein, regulates the JUN N-terminal kinase signal transduction pathway in Drosophila. Mol Cell Biol. 2002 Mar; 22(6):1792-803. Chen HW, Marinissen MJ, Oh SW, Chen X, Melnick M, Perrimon N, Gutkind JS, Hou SX. PMID: 11865058; PMCID: PMC135602.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    402. mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family. Genes Dev. 2002 Feb 01; 16(3):388-98. Chen HW, Chen X, Oh SW, Marinissen MJ, Gutkind JS, Hou SX. PMID: 11825879; PMCID: PMC155335.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    403. Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. Cancer Cell. 2002 Feb; 1(1):53-62. Orsulic S, Li Y, Soslow RA, Vitale-Cross LA, Gutkind JS, Varmus HE. PMID: 12086888; PMCID: PMC2267863.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansAnimals
    404. Regulation of p73 by c-Abl through the p38 MAP kinase pathway. Oncogene. 2002 Jan 31; 21(6):974-9. Sanchez-Prieto R, Sanchez-Arevalo VJ, Servitja JM, Gutkind JS. PMID: 11840343.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    405. Potent transforming activity of the small GTP-binding protein Rit in NIH 3T3 cells: evidence for a role of a p38gamma-dependent signaling pathway. FEBS Lett. 2002 Jan 30; 511(1-3):15-20. Sakabe K, Teramoto H, Zohar M, Behbahani B, Miyazaki H, Chikumi H, Gutkind JS. PMID: 11821041.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    406. Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase. J Biol Chem. 2002 Apr 05; 277(14):12463-73. Chikumi H, Fukuhara S, Gutkind JS. PMID: 11799111.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    407. Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB. Oncogene. 2002 Jan 10; 21(2):207-16. Murga C, Zohar M, Teramoto H, Gutkind JS. PMID: 11803464.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    408. Functional roles of Akt signaling in mouse skin tumorigenesis. Oncogene. 2002 Jan 03; 21(1):53-64. Segrelles C, Ruiz S, Perez P, Murga C, Santos M, Budunova IV, Martínez J, Larcher F, Slaga TJ, Gutkind JS, Jorcano JL, Paramio JM. PMID: 11791176.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    409. Regulation of mitogen-activated protein kinases by G-protein-coupled receptors. Methods Enzymol. 2002; 345:437-47. Chiariello M, Gutkind JS. PMID: 11665627.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    410. Proteomic profiling of the cancer microenvironment by antibody arrays. Proteomics. 2001 Oct; 1(10):1271-8. Knezevic V, Leethanakul C, Bichsel VE, Worth JM, Prabhu VV, Gutkind JS, Liotta LA, Munson PJ, Petricoin EF, Krizman DB. PMID: 11721638.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    411. MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF. Biochem Biophys Res Commun. 2001 Sep 14; 287(1):292-300. Sodhi A, Montaner S, Miyazaki H, Gutkind JS. PMID: 11549290.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    412. Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases. Structure. 2001 Jul 03; 9(7):559-69. Longenecker KL, Lewis ME, Chikumi H, Gutkind JS, Derewenda ZS. PMID: 11470431.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    413. G-protein-coupled receptors and signaling networks: emerging paradigms. Trends Pharmacol Sci. 2001 Jul; 22(7):368-76. Marinissen MJ, Gutkind JS. PMID: 11431032.
      View in: PubMed   Mentions: 293     Fields:    Translation:HumansAnimalsCells
    414. The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth. J Biol Chem. 2001 Aug 24; 276(34):31674-83. Yuan PX, Huang LD, Jiang YM, Gutkind JS, Manji HK, Chen G. PMID: 11418608.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansCells
    415. Regulation of c-myc expression by PDGF through Rho GTPases. Nat Cell Biol. 2001 Jun; 3(6):580-6. Chiariello M, Marinissen MJ, Gutkind JS. PMID: 11389443.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    416. RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho? Oncogene. 2001 Mar 26; 20(13):1661-8. Fukuhara S, Chikumi H, Gutkind JS. PMID: 11313914.
      View in: PubMed   Mentions: 80     Fields:    Translation:Cells
    417. The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor promotes endothelial cell survival through the activation of Akt/protein kinase B. Cancer Res. 2001 Mar 15; 61(6):2641-8. Montaner S, Sodhi A, Pece S, Mesri EA, Gutkind JS. PMID: 11289142.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    418. Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway. Genes Dev. 2001 Mar 01; 15(5):535-53. Marinissen MJ, Chiariello M, Gutkind JS. PMID: 11238375; PMCID: PMC312639.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    419. Granulocyte colony-stimulating factor induces ERK5 activation, which is differentially regulated by protein-tyrosine kinases and protein kinase C. Regulation of cell proliferation and survival. J Biol Chem. 2001 Apr 06; 276(14):10811-6. Dong F, Gutkind JS, Larner AC. PMID: 11278431.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    420. New approaches to the understanding of the molecular basis of oral cancer. Crit Rev Oral Biol Med. 2001; 12(1):55-63. Patel V, Leethanakul C, Gutkind JS. PMID: 11349962.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    421. Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation. J Biol Chem. 2000 Dec 29; 275(52):41227-33. Pece S, Gutkind JS. PMID: 10969083.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansCells
    422. Induction of apoptosis in head-and-neck squamous carcinoma cells by gamma-irradiation and bleomycin is p53-independent. Int J Cancer. 2000 Dec 01; 88(5):737-43. Patel V, Ensley JF, Gutkind JS, Yeudall WA. PMID: 11072242.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    423. Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho. FEBS Lett. 2000 Nov 24; 485(2-3):183-8. Fukuhara S, Chikumi H, Gutkind JS. PMID: 11094164.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    424. Loss of PTEN expression leading to high Akt activation in human multiple myelomas. Blood. 2000 Nov 15; 96(10):3560-8. Hyun T, Yam A, Pece S, Xie X, Zhang J, Miki T, Gutkind JS, Li W. PMID: 11071655.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    425. Role of the cAMP and MAPK pathways in the transformation of mouse 3T3 fibroblasts by a TSHR gene constitutively activated by point mutation. Oncogene. 2000 Oct 05; 19(42):4896-905. Du Villard JA, Wicker R, Crespo P, Russo D, Filetti S, Gutkind JS, Sarasin A, Suárez HG. PMID: 11039907.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    426. Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity. Blood. 2000 Sep 01; 96(5):1844-52. Visconti R, Gadina M, Chiariello M, Chen EH, Stancato LF, Gutkind JS, O'Shea JJ. PMID: 10961885.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    427. Gene expression profiles in squamous cell carcinomas of the oral cavity: use of laser capture microdissection for the construction and analysis of stage-specific cDNA libraries. Oral Oncol. 2000 Sep; 36(5):474-83. Leethanakul C, Patel V, Gillespie J, Shillitoe E, Kellman RM, Ensley JF, Limwongse V, Emmert-Buck MR, Krizman DB, Gutkind JS. PMID: 10964057.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    428. The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha. Cancer Res. 2000 Sep 01; 60(17):4873-80. Sodhi A, Montaner S, Patel V, Zohar M, Bais C, Mesri EA, Gutkind JS. PMID: 10987301.
      View in: PubMed   Mentions: 176     Fields:    Translation:AnimalsCells
    429. The Rho family GTPase Cdc42 regulates the activation of Ras/MAP kinase by the exchange factor Ras-GRF. J Biol Chem. 2000 Aug 25; 275(34):26441-8. Arozarena I, Aaronson DS, Matallanas D, Sanz V, Ajenjo N, Tenbaum SP, Teramoto H, Ighishi T, Zabala JC, Gutkind JS, Crespo P. PMID: 10840034.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    430. Regulation of cyclin-dependent kinase (Cdk) 2 Thr-160 phosphorylation and activity by mitogen-activated protein kinase in late G1 phase. Biochem J. 2000 Aug 01; 349 Pt 3:869-76. Chiariello M, Gomez E, Gutkind JS. PMID: 10903150; PMCID: PMC1221216.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    431. Isoproterenol inhibits fibroblast growth factor-2-induced growth of renal epithelial cells. Pediatr Nephrol. 2000 Aug; 14(8-9):726-34. Izevbigie EB, Gutkind JS, Ray PE. PMID: 10955916.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    432. SPECs, small binding proteins for Cdc42. J Biol Chem. 2000 Jul 28; 275(30):22650-6. Pirone DM, Fukuhara S, Gutkind JS, Burbelo PD. PMID: 10816584.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    433. Signaling from G protein-coupled receptors to ERK5/Big MAPK 1 involves Galpha q and Galpha 12/13 families of heterotrimeric G proteins. Evidence for the existence of a novel Ras AND Rho-independent pathway. J Biol Chem. 2000 Jul 14; 275(28):21730-6. Fukuhara S, Marinissen MJ, Chiariello M, Gutkind JS. PMID: 10781600.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    434. Regulation of mitogen-activated protein kinase signaling networks by G protein-coupled receptors. Sci STKE. 2000 Jul 11; 2000(40):re1. Gutkind JS. PMID: 11752597.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    435. Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays. Oncogene. 2000 Jun 29; 19(28):3220-4. Leethanakul C, Patel V, Gillespie J, Pallente M, Ensley JF, Koontongkaew S, Liotta LA, Emmert-Buck M, Gutkind JS. PMID: 10918578.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    436. Tensin can induce JNK and p38 activation. Biochem Biophys Res Commun. 2000 Jun 16; 272(3):717-20. Katz BZ, Zohar M, Teramoto H, Matsumoto K, Gutkind JS, Lin DC, Lin S, Yamada KM. PMID: 10860821.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    437. A new twist for the tumour suppressor hamartin. Nat Cell Biol. 2000 May; 2(5):E76-8. Fukuhara S, Gutkind JS. PMID: 10806489.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    438. A role for the p38 mitogen-acitvated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents. Cancer Res. 2000 May 01; 60(9):2464-72. Sanchez-Prieto R, Rojas JM, Taya Y, Gutkind JS. PMID: 10811125.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    439. Angiotensin II and basic fibroblast growth factor mitogenic pathways in human fetal mesangial cells. Pediatr Res. 2000 May; 47(5):614-21. Izevbigie EB, Gutkind JS, Ray PE. PMID: 10813586.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    440. A novel role for phosphatidylinositol 3-kinase beta in signaling from G protein-coupled receptors to Akt. J Biol Chem. 2000 Apr 21; 275(16):12069-73. Murga C, Fukuhara S, Gutkind JS. PMID: 10766839.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    441. Deletion of the COOH terminus converts the ST5 p70 protein from an inhibitor of RAS signaling to an activator with transforming activity in NIH-3T3 cells. J Biol Chem. 2000 Mar 03; 275(9):6560-5. Majidi M, Gutkind JS, Lichy JH. PMID: 10692462.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    442. Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation. Mol Cell Biol. 2000 Mar; 20(5):1747-58. Chiariello M, Marinissen MJ, Gutkind JS. PMID: 10669751; PMCID: PMC85357.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    443. Cbl-b regulates the CD28 dependence of T-cell activation. Nature. 2000 Jan 13; 403(6766):216-20. Chiang YJ, Kole HK, Brown K, Naramura M, Fukuhara S, Hu RJ, Jang IK, Gutkind JS, Shevach E, Gu H. PMID: 10646609.
      View in: PubMed   Mentions: 236     Fields:    Translation:AnimalsCells
    444. Genome-wide analysis of oral cancer--early results from the Cancer Genome Anatomy Project. Oral Oncol. 2000 Jan; 36(1):8-16. Shillitoe EJ, May M, Patel V, Lethanakul C, Ensley JF, Strausberg RL, Gutkind JS. PMID: 10889913.
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    445. Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor. J Biol Chem. 1999 Nov 19; 274(47):33287-95. Tassi E, Biesova Z, Di Fiore PP, Gutkind JS, Wong WT. PMID: 10559204.
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    446. Divergent signaling pathways link focal adhesion kinase to mitogen-activated protein kinase cascades. Evidence for a role of paxillin in c-Jun NH(2)-terminal kinase activation. J Biol Chem. 1999 Oct 22; 274(43):30738-46. Igishi T, Fukuhara S, Patel V, Katz BZ, Yamada KM, Gutkind JS. PMID: 10521463.
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    447. Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex. J Biol Chem. 1999 Jul 02; 274(27):19347-51. Pece S, Chiariello M, Murga C, Gutkind JS. PMID: 10383446.
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    448. A network of mitogen-activated protein kinases links G protein-coupled receptors to the c-jun promoter: a role for c-Jun NH2-terminal kinase, p38s, and extracellular signal-regulated kinase 5. Mol Cell Biol. 1999 Jun; 19(6):4289-301. Marinissen MJ, Chiariello M, Pallante M, Gutkind JS. PMID: 10330170; PMCID: PMC104389.
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    449. Insulin-like growth factor I synergizes with interleukin 4 for hematopoietic cell proliferation independent of insulin receptor substrate expression. Mol Cell Biol. 1999 May; 19(5):3816-28. Soon L, Flechner L, Gutkind JS, Wang LH, Baserga R, Pierce JH, Li W. PMID: 10207105; PMCID: PMC84225.
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    450. A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. J Biol Chem. 1999 Feb 26; 274(9):5868-79. Fukuhara S, Murga C, Zohar M, Igishi T, Gutkind JS. PMID: 10026210.
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    451. Role of mitogen-activated protein kinases and c-Jun/AP-1 trans-activating activity in the regulation of protease mRNAs and the malignant phenotype in NIH 3T3 fibroblasts. J Biol Chem. 1999 Jan 08; 274(2):801-13. Janulis M, Silberman S, Ambegaokar A, Gutkind JS, Schultz RM. PMID: 9873019.
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    452. Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis. J Clin Invest. 1998 Nov 01; 102(9):1674-81. Patel V, Senderowicz AM, Pinto D, Igishi T, Raffeld M, Quintanilla-Martinez L, Ensley JF, Sausville EA, Gutkind JS. PMID: 9802881; PMCID: PMC509115.
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    453. The ras-related GTPase rac1 regulates a proliferative pathway selectively utilized by G-protein coupled receptors. Oncogene. 1998 Sep 24; 17(12):1617-23. Burstein ES, Hesterberg DJ, Gutkind JS, Brann MR, Currier EA, Messier TL. PMID: 9794239.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    454. Cell growth control by G protein-coupled receptors: from signal transduction to signal integration. Oncogene. 1998 Sep 17; 17(11 Reviews):1331-42. Gutkind JS. PMID: 9779981.
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    455. Effector domain mutants of Rho dissociate cytoskeletal changes from nuclear signaling and cellular transformation. Oncogene. 1998 Aug 27; 17(8):991-8. Zohar M, Teramoto H, Katz BZ, Yamada KM, Gutkind JS. PMID: 9747878.
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    456. Activation of Akt/protein kinase B by G protein-coupled receptors. A role for alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinasegamma. J Biol Chem. 1998 Jul 24; 273(30):19080-5. Murga C, Laguinge L, Wetzker R, Cuadrado A, Gutkind JS. PMID: 9668091.
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    457. A common requirement for the catalytic activity and both SH2 domains of SHP-2 in mitogen-activated protein (MAP) kinase activation by the ErbB family of receptors. A specific role for SHP-2 in map, but not c-Jun amino-terminal kinase activation. J Biol Chem. 1998 Jul 03; 273(27):16643-6. Deb TB, Wong L, Salomon DS, Zhou G, Dixon JE, Gutkind JS, Thompson SA, Johnson GR. PMID: 9642214.
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    458. Signalling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKS): evidence for a divergence of the ERKs and JNKs pathways induced by Ret. Oncogene. 1998 May 14; 16(19):2435-45. Chiariello M, Visconti R, Carlomagno F, Melillo RM, Bucci C, de Franciscis V, Fox GM, Jing S, Coso OA, Gutkind JS, Fusco A, Santoro M. PMID: 9627110.
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    459. Transforming G protein-coupled receptors block insulin and ras-induced adipocytic differentiation in 3T3-L1 cells: evidence for a PKC and MAP kinase independent pathway. Biochem Biophys Res Commun. 1998 Apr 17; 245(2):554-61. Crespo P, Font de Mora J, Aaronson DS, Santos E, Gutkind JS. PMID: 9571194.
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    460. Tyrosine kinases of the Src family participate in signaling to MAP kinase from both Gq and Gi-coupled receptors. Biochem Biophys Res Commun. 1998 Mar 06; 244(1):5-10. Igishi T, Gutkind JS. PMID: 9514877.
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    461. Galpha12 requires acylation for its transforming activity. Biochemistry. 1998 Mar 03; 37(9):3196-202. Jones TL, Gutkind JS. PMID: 9485474.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    462. Phosphoinositide 3-kinase gamma is a mediator of Gbetagamma-dependent Jun kinase activation. J Biol Chem. 1998 Jan 30; 273(5):2505-8. Lopez-Ilasaca M, Gutkind JS, Wetzker R. PMID: 9446550.
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    463. The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades. J Biol Chem. 1998 Jan 23; 273(4):1839-42. Gutkind JS. PMID: 9442012.
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    464. [The pathway connecting muscarinic acetylcholine receptors to the nucleus involves small GTP-binding proteins]. Tanpakushitsu Kakusan Koso. 1998 Jan; 43(1):35-41. Teramoto H, Gutkind JS. PMID: 9455149.
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    465. G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature. 1998 Jan 01; 391(6662):86-9. Bais C, Santomasso B, Coso O, Arvanitakis L, Raaka EG, Gutkind JS, Asch AS, Cesarman E, Gershengorn MC, Mesri EA, Gerhengorn MC. PMID: 9422510.
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    466. The constitutively active mutant Galpha13 transforms mouse fibroblast cells deficient in insulin-like growth factor-I receptor. J Biol Chem. 1997 Nov 21; 272(47):29438-41. Liu JL, Blakesley VA, Gutkind JS, LeRoith D. PMID: 9368001.
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    467. Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation. Oncogene. 1997 Nov 20; 15(21):2511-20. Bustelo XR, Crespo P, López-Barahona M, Gutkind JS, Barbacid M. PMID: 9399639.
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    468. A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha. J Biol Chem. 1997 Oct 10; 272(41):25816-23. Jin DY, Teramoto H, Giam CZ, Chun RF, Gutkind JS, Jeang KT. PMID: 9325311.
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    469. The small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation. Proc Natl Acad Sci U S A. 1997 Sep 16; 94(19):10098-103. Fromm C, Coso OA, Montaner S, Xu N, Gutkind JS. PMID: 9294169; PMCID: PMC23316.
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    470. Signaling from G protein-coupled receptors to the c-jun promoter involves the MEF2 transcription factor. Evidence for a novel c-jun amino-terminal kinase-independent pathway. J Biol Chem. 1997 Aug 15; 272(33):20691-7. Coso OA, Montaner S, Fromm C, Lacal JC, Prywes R, Teramoto H, Gutkind JS. PMID: 9252389.
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    471. PLC-gamma activation is required for PDGF-betaR-mediated mitogenesis and monocytic differentiation of myeloid progenitor cells. Oncogene. 1997 Jul 31; 15(5):585-93. Alimandi M, Heidaran MA, Gutkind JS, Zhang J, Ellmore N, Valius M, Kazlauskas A, Pierce JH, Li W. PMID: 9247312.
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    472. The p53 tumor suppressor targets a novel regulator of G protein signaling. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):7868-72. Buckbinder L, Velasco-Miguel S, Chen Y, Xu N, Talbott R, Gelbert L, Gao J, Seizinger BR, Gutkind JS, Kley N. PMID: 9223279; PMCID: PMC21521.
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    473. Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway. J Biol Chem. 1997 Apr 18; 272(16):10751-5. Teramoto H, Salem P, Robbins KC, Bustelo XR, Gutkind JS. PMID: 9099726.
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    474. Requirement of phosphatidylinositol-3 kinase for activation of JNK/SAPKs by PDGF. Biochem Biophys Res Commun. 1997 Mar 17; 232(2):273-7. Lopez-Ilasaca M, Li W, Uren A, Yu JC, Kazlauskas A, Gutkind JS, Heidaran MA. PMID: 9125162.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    475. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma. Science. 1997 Jan 17; 275(5298):394-7. Lopez-Ilasaca M, Crespo P, Pellici PG, Gutkind JS, Wetzker R. PMID: 8994038.
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    476. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature. 1997 Jan 09; 385(6612):169-72. Crespo P, Schuebel KE, Ostrom AA, Gutkind JS, Bustelo XR. PMID: 8990121.
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    477. The pathway connecting m2 receptors to the nucleus involves small GTP-binding proteins acting on divergent MAP kinase cascades. Life Sci. 1997; 60(13-14):999-1006. Gutkind JS, Crespo P, Xu N, Teramoto H, Coso OA. PMID: 9121367.
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    478. Selective activation of effector pathways by brain-specific G protein beta5. J Biol Chem. 1996 Dec 27; 271(52):33575-9. Zhang S, Coso OA, Lee C, Gutkind JS, Simonds WF. PMID: 8969224.
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    479. Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J Cell Biol. 1996 Dec; 135(6 Pt 1):1633-42. Miyamoto S, Teramoto H, Gutkind JS, Yamada KM. PMID: 8978828; PMCID: PMC2133938.
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    480. Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family. J Biol Chem. 1996 Nov 01; 271(44):27225-8. Teramoto H, Coso OA, Miyata H, Igishi T, Miki T, Gutkind JS. PMID: 8910292.
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    481. The small GTP-binding protein rho activates c-Jun N-terminal kinases/stress-activated protein kinases in human kidney 293T cells. Evidence for a Pak-independent signaling pathway. J Biol Chem. 1996 Oct 18; 271(42):25731-4. Teramoto H, Crespo P, Coso OA, Igishi T, Xu N, Gutkind JS. PMID: 8824197.
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    482. Regulation of reactive-oxygen-species generation in fibroblasts by Rac1. Biochem J. 1996 Sep 01; 318 ( Pt 2):379-82. Sundaresan M, Yu ZX, Ferrans VJ, Sulciner DJ, Gutkind JS, Irani K, Goldschmidt-Clermont PJ, Finkel T. PMID: 8809022; PMCID: PMC1217632.
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    483. A C-terminal mutant of the G protein beta subunit deficient in the activation of phospholipase C-beta. J Biol Chem. 1996 Aug 16; 271(33):20208-12. Zhang S, Coso OA, Collins R, Gutkind JS, Simonds WF. PMID: 8702747.
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    484. Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav. Oncogene. 1996 Aug 01; 13(3):455-60. Crespo P, Bustelo XR, Aaronson DS, Coso OA, Lopez-Barahona M, Barbacid M, Gutkind JS. PMID: 8760286.
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    485. Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells. Genes Dev. 1996 Jun 15; 10(12):1455-66. Kieser A, Seitz T, Adler HS, Coffer P, Kremmer E, Crespo P, Gutkind JS, Henderson DW, Mushinski JF, Kolch W, Mischak H. PMID: 8666230.
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    486. Signaling from G protein-coupled receptors to c-Jun kinase involves beta gamma subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway. J Biol Chem. 1996 Feb 23; 271(8):3963-6. Coso OA, Teramoto H, Simonds WF, Gutkind JS. PMID: 8626724.
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    487. The PH domain of Ras-GAP is sufficient for in vitro binding to beta gamma subunits of heterotrimeric G proteins. Cell Mol Neurobiol. 1996 Feb; 16(1):51-9. Xu N, Coso O, Mahadevan D, De Blasi A, Goldsmith PK, Simonds WF, Gutkind JS. PMID: 8714559.
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    488. Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. J Cell Biol. 1995 Nov; 131(3):791-805. Miyamoto S, Teramoto H, Coso OA, Gutkind JS, Burbelo PD, Akiyama SK, Yamada KM. PMID: 7593197; PMCID: PMC2120620.
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    489. Dual effect of beta-adrenergic receptors on mitogen-activated protein kinase. Evidence for a beta gamma-dependent activation and a G alpha s-cAMP-mediated inhibition. J Biol Chem. 1995 Oct 20; 270(42):25259-65. Crespo P, Cachero TG, Xu N, Gutkind JS. PMID: 7559665.
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    490. Overexpression of mammalian protein kinase C-zeta does not affect the growth characteristics of NIH 3T3 cells. Biochem Biophys Res Commun. 1995 Aug 04; 213(1):266-72. Crespo P, Mischak H, Gutkind JS. PMID: 7639744.
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    491. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell. 1995 Jun 30; 81(7):1137-46. Coso OA, Chiariello M, Yu JC, Teramoto H, Crespo P, Xu N, Miki T, Gutkind JS. PMID: 7600581.
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    492. Transforming G protein-coupled receptors potently activate JNK (SAPK). Evidence for a divergence from the tyrosine kinase signaling pathway. J Biol Chem. 1995 Mar 10; 270(10):5620-4. Coso OA, Chiariello M, Kalinec G, Kyriakis JM, Woodgett J, Gutkind JS. PMID: 7890682.
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    493. Biological function of PDGF-induced PI-3 kinase activity: its role in alpha PDGF receptor-mediated mitogenic signaling. J Cell Biol. 1994 Oct; 127(2):479-87. Yu JC, Gutkind JS, Mahadevan D, Li W, Meyers KA, Pierce JH, Heidaran MA. PMID: 7929590; PMCID: PMC2120211.
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    494. Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway. J Biol Chem. 1994 Aug 19; 269(33):21103-9. Crespo P, Xu N, Daniotti JL, Troppmair J, Rapp UR, Gutkind JS. PMID: 8063729.
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    495. Novel 1-phenylcycloalkanecarboxylic acid derivatives are potent and selective sigma 1 ligands. J Med Chem. 1994 Jul 22; 37(15):2285-91. Calderon SN, Izenwasser S, Heller B, Gutkind JS, Mattson MV, Su TP, Newman AH. PMID: 8057277.
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    496. Potent transforming activity of the G13 alpha subunit defines a novel family of oncogenes. Biochem Biophys Res Commun. 1994 Jun 15; 201(2):603-9. Xu N, Voyno-Yasenetskaya T, Gutkind JS. PMID: 8002992.
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    497. Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits. Nature. 1994 Jun 02; 369(6479):418-20. Crespo P, Xu N, Simonds WF, Gutkind JS. PMID: 8196770.
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    498. The non-catalytic domain of ras-GAP inhibits transformation induced by G protein coupled receptors. Oncogene. 1994 Feb; 9(2):597-601. Xu N, McCormick F, Gutkind JS. PMID: 8290270.
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    499. A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells. Proc Natl Acad Sci U S A. 1993 Jul 15; 90(14):6741-5. Xu N, Bradley L, Ambdukar I, Gutkind JS. PMID: 8393576; PMCID: PMC47008.
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    500. Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells. Proc Natl Acad Sci U S A. 1993 May 01; 90(9):4032-6. Wang LM, Keegan AD, Li W, Lienhard GE, Pacini S, Gutkind JS, Myers MG, Sun XJ, White MF, Aaronson SA, et al. PMID: 7683417; PMCID: PMC46440.
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    501. Transforming G protein-coupled receptors transduce potent mitogenic signals in NIH 3T3 cells independent on cAMP inhibition or conventional protein kinase C. Oncogene. 1993 Jan; 8(1):19-26. Stephens EV, Kalinec G, Brann MR, Gutkind JS. PMID: 8380916.
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    502. IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells. EMBO J. 1992 Dec; 11(13):4899-908. Wang LM, Keegan AD, Paul WE, Heidaran MA, Gutkind JS, Pierce JH. PMID: 1334461; PMCID: PMC556967.
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    503. Activation of transforming G protein-coupled receptors induces rapid tyrosine phosphorylation of cellular proteins, including p125FAK and the p130 v-src substrate. Biochem Biophys Res Commun. 1992 Oct 15; 188(1):155-61. Gutkind JS, Robbins KC. PMID: 1329743.
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    504. Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells. Mol Cell Biol. 1992 Oct; 12(10):4687-93. Kalinec G, Nazarali AJ, Hermouet S, Xu N, Gutkind JS. PMID: 1328859; PMCID: PMC360395.
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    505. Identification of distinct populations of PI-3 kinase activity following T-cell activation. Oncogene. 1992 Apr; 7(4):719-25. Thompson PA, Gutkind JS, Robbins KC, Ledbetter JA, Bolen JB. PMID: 1373484.
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    506. Fc epsilon RI-induced protein tyrosine phosphorylation of pp72 in rat basophilic leukemia cells (RBL-2H3). Evidence for a novel signal transduction pathway unrelated to G protein activation and phosphatidylinositol hydrolysis. J Biol Chem. 1992 Mar 15; 267(8):5434-41. Stephan V, Benhamou M, Gutkind JS, Robbins KC, Siraganian RP. PMID: 1372002.
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    507. Diverse biologic properties imparted by the c-fgr proto-oncogene. J Biol Chem. 1992 Feb 15; 267(5):3460-5. Sartor O, Moriuchi R, Sameshima JH, Severino M, Gutkind JS, Robbins KC. PMID: 1737799.
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    508. Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells. Proc Natl Acad Sci U S A. 1991 Dec 01; 88(23):10455-9. Hermouet S, Merendino JJ, Gutkind JS, Spiegel AM. PMID: 1660138; PMCID: PMC52947.
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    509. Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction. Mol Cell Biol. 1991 Jul; 11(7):3780-5. Yu JC, Heidaran MA, Pierce JH, Gutkind JS, Lombardi D, Ruggiero M, Aaronson SA. PMID: 1646396; PMCID: PMC361148.
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    510. Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes. Proc Natl Acad Sci U S A. 1991 Jun 01; 88(11):4703-7. Gutkind JS, Novotny EA, Brann MR, Robbins KC. PMID: 1905013; PMCID: PMC51734.
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    511. A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes. Mol Cell Biol. 1991 Mar; 11(3):1500-7. Gutkind JS, Link DC, Katamine S, Lacal P, Miki T, Ley TJ, Robbins KC. PMID: 1847500; PMCID: PMC369433.
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    512. Selective effects of activation of protein kinase C isozymes on cyclic AMP accumulation. Mol Pharmacol. 1991 Feb; 39(2):124-9. Gusovsky F, Gutkind JS. PMID: 1847491.
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    513. Deletion or substitution within the alpha platelet-derived growth factor receptor kinase insert domain: effects on functional coupling with intracellular signaling pathways. Mol Cell Biol. 1991 Jan; 11(1):134-42. Heidaran MA, Pierce JH, Lombardi D, Ruggiero M, Gutkind JS, Matsui T, Aaronson SA. PMID: 1702511; PMCID: PMC359603.
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    514. Effects of clenbuterol treatment on the responses to vasodilators in urethane-anaesthetized rats. J Pharm Pharmacol. 1990 Oct; 42(10):735-7. Kazanietz MG, Gutkind JS, Enero MA. PMID: 1982150.
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    515. Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release. Proc Natl Acad Sci U S A. 1990 Jul; 87(14):5327-30. Benhamou M, Gutkind JS, Robbins KC, Siraganian RP. PMID: 1695377; PMCID: PMC54316.
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    516. Autoradiographic localization of osteogenin binding sites in cartilage and bone during rat embryonic development. Dev Biol. 1990 Jul; 140(1):209-14. Vukicevic S, Paralkar VM, Cunningham NS, Gutkind JS, Reddi AH. PMID: 2358119.
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    517. Thrombin-dependent association of phosphatidylinositol-3 kinase with p60c-src and p59fyn in human platelets. Mol Cell Biol. 1990 Jul; 10(7):3806-9. Gutkind JS, Lacal PM, Robbins KC. PMID: 2162481; PMCID: PMC360840.
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    518. Decreased angiotensin II receptors in subfornical organ of spontaneously hypertensive rats after chronic antihypertensive treatment with enalapril. Am J Hypertens. 1990 Jan; 3(1):59-61. Nazarali AJ, Gutkind JS, Correa FM, Saavedra JM. PMID: 2405884.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    519. Further evidence of interaction between vasodilator beta 2- and vasoconstrictor alpha 2-adrenoceptor-mediated responses in maintaining vascular tone in anesthetized rats. J Cardiovasc Pharmacol. 1989 Dec; 14(6):874-80. Kazanietz MG, Gutkind JS, Puyo A, Armando I, Enero MA. PMID: 2481776.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    520. Expression of the fgr protooncogene product as a function of myelomonocytic cell maturation. J Cell Biol. 1989 Dec; 109(6 Pt 1):3129-36. Notario V, Gutkind JS, Imaizumi M, Katamine S, Robbins KC. PMID: 2687293; PMCID: PMC2115966.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    521. Calibration of 125I-polymer standards with 125I-brain paste standards for use in quantitative receptor autoradiography. J Neurosci Methods. 1989 Dec; 30(3):247-53. Nazarali AJ, Gutkind JS, Saavedra JM. PMID: 2607785.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    522. Translocation of the FGR protein-tyrosine kinase as a consequence of neutrophil activation. Proc Natl Acad Sci U S A. 1989 Nov; 86(22):8783-7. Gutkind JS, Robbins KC. PMID: 2682659; PMCID: PMC298374.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    523. Enalapril decreases angiotensin II receptors in subfornical organ of SHR. Am J Physiol. 1989 Jun; 256(6 Pt 2):H1609-14. Nazarali AJ, Gutkind JS, Correa FM, Saavedra JM. PMID: 2544109.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    524. Pressor response induced by clenbuterol treatment in immobilized normotensive rats. J Cardiovasc Pharmacol. 1989 May; 13(5):793-8. Gutkind JS, Kazanietz MG, Armando I, Puyó A, Enero MA. PMID: 2472529.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    525. The actin domain of Gardner-Rasheed feline sarcoma virus inhibits kinase and transforming activities. J Virol. 1989 Apr; 63(4):1715-20. Sugita K, Gutkind JS, Katamine S, Kawakami T, Robbins KC. PMID: 2538651; PMCID: PMC248428.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    526. Regulation of brain atrial natriuretic peptide and angiotensin receptors: quantitative autoradiographic studies. Int Rev Neurobiol. 1989; 31:257-96. Saavedra JM, Castrén E, Gutkind JS, Nazarali AJ. PMID: 2557296.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    527. Effect of chronic administration of the converting enzyme inhibitor enalapril (MK 421) on brain atrial natriuretic peptide receptors in Wistar-Kyoto and spontaneously hypertensive rats. Brain Res. 1988 Dec 13; 475(1):134-40. Nazarali AJ, Gutkind JS, Correa FM, Saavedra JM. PMID: 2850834.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    528. Increased angiotensin II receptors in brain nuclei of DOCA-salt hypertensive rats. Am J Physiol. 1988 Sep; 255(3 Pt 2):H646-50. Gutkind JS, Kurihara M, Saavedra JM. PMID: 3414825.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    529. Autoradiographic quantification of vasoactive intestinal peptide binding sites in sections from human blood mononuclear cell pellets. Neuropsychopharmacology. 1988 Sep; 1(3):251-5. Gutkind JS, Kurihara M, Castrén E, Saavedra JM. PMID: 2855201.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    530. Alteration of atrial natriuretic peptide binding sites in spontaneously hypertensive rats. Am J Hypertens. 1988 Jul; 1(3 Pt 3):12S-14S. Kurihara M, Gutkind JS, Saavedra JM. PMID: 2970851.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    531. Characterization of beta-adrenergic receptors in sections from human blood lymphocyte pellets by quantitative autoradiography. Biol Psychiatry. 1988 Apr 01; 23(7):749-54. Kurihara M, Castrén E, Gutkind JS, Saito K, Saavedra JM. PMID: 2835997.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    532. Increased concentration of angiotensin II binding sites in selected brain areas of spontaneously hypertensive rats. J Hypertens. 1988 Jan; 6(1):79-84. Gutkind JS, Kurihara M, Castren E, Saavedra JM. PMID: 3351297.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    533. Decreased angiotensin II binding affinity and binding capacity in the anterior pituitary gland of adult spontaneously hypertensive rats. Life Sci. 1988; 43(5):445-51. Gutkind JS, Castrén E, Saavedra JM. PMID: 3398707.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    534. Lower number of atrial natriuretic peptide receptors in thymocytes and spleen cells of spontaneously hypertensive rats. Biochem Biophys Res Commun. 1987 Dec 31; 149(3):1132-40. Kurihara M, Castrén E, Gutkind JS, Saavedra JM. PMID: 2827653.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    535. Angiotensin II binding sites in the conduction system of rat hearts. Am J Physiol. 1987 Dec; 253(6 Pt 2):H1618-22. Saito K, Gutkind JS, Saavedra JM. PMID: 3425757.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    536. Regulation of angiotensin II binding sites in the subfornical organ and other rat brain nuclei after water deprivation. Cell Mol Neurobiol. 1987 Dec; 7(4):447-55. Nazarali AJ, Gutkind JS, Saavedra JM. PMID: 3451799.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    537. Atrial natriuretic peptide receptors in sympathetic ganglia: biochemical response and alterations in genetically hypertensive rats. Biochem Biophys Res Commun. 1987 Nov 30; 149(1):65-72. Gutkind JS, Kurihara M, Castrén E, Saavedra JM. PMID: 2825702.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    538. Specific angiotensin II binding sites in the rat stellate and superior cervical ganglia. Brain Res. 1987 Oct 06; 422(2):347-51. Castrén E, Kurihara M, Gutkind JS, Saavedra JM. PMID: 3676793.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    539. Different pharmacological interaction of clonidine and guanabenz with antidepressive drugs. Clin Exp Hypertens A. 1987; 9(10):1531-47. Gutkind JS, Enero MA. PMID: 2824097.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
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