J. Silvio Gutkind, Ph.D.

Title(s)Professor, Pharmacology
SchoolHealth Sciences
Address3855 Health Sciences Drive
La Jolla CA 92093
Phone858-534-5980
ORCID ORCID Icon0000-0002-5150-4482 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Buenos Aires, Buenos Aires, ArgentinaPh.D.1985Pharmacology and Biochemistry
    University of Buenos Aires, Buenos Aires, ArgentinaBiochemistry Degree (M.Sc.)1983Biochemistry
    University of Buenos Aires, Buenos Aires, ArgentinaPharmacy Degree (M.Sc.)1980Pharmacology
    Collapse Awards and Honors
    National Academy of Medicine, USA2019Elected, National Academy of Medicine
    Gordon Conference in Molecular Pharmacology, Ventura CA2019Elected Co-Chair, Gordon Conference in Molecular Pharmacology
    American Society for Pharmacology and Experimental Therapeutics (ASPET)2019Elected Chair, Division of Molecular Pharmacology
    International Association of Dental Research (IADR)2017Outstanding Scientist Award
    Pharmaceutical Research and Manufacturers of America (PhRMA)2015Research & Hope Award for “Excellence in Academic Research”
    Annual Meeting and 5th World Congress-IFHNOS2014Elected, Keynote Lecture, 2014 American Head and Neck Society (AHNS)
    Israel Cancer Research Foundation2012Elliot Osserman Award
    Israel Cancer Research Foundation2005Elliot Osserman Award
    NIH2005NIH Director's Award
    International Association of Dental Research (IADR) 2004Distinguished Scientist Award, Oral Medicine and Pathology
    NIDCR, NIH1997NIDR Director’s Exemplary Service Award
    NIH1996NIH Merit Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Multidisciplinary Educational Approach to Reducing Cancer Disparities
    NIH R25CA221779Sep 1, 2019 - Aug 31, 2024
    Role: Principal Investigator
    Stimulating Neo-Antigen Specific T Cell Responses in Head and Neck Cancers
    NIH U01DE028227Sep 19, 2018 - Aug 31, 2023
    Role: Principal Investigator, MPI
    Targeting the EGFR-PI3K/mTOR Signaling Circuitry: A Network-Based Approach for Oral Cancer Precision Therapy
    NIH R01DE026870Aug 1, 2018 - Jul 31, 2023
    Role: Principal Investigator
    Area C: Genome-wide identification and targeting of resistance to cancer therapy
    NIH R33CA225291Sep 30, 2017 - Aug 31, 2020
    Role: Principal Investigator
    Targeting Signaling Vulnerabilities for Oral Cancer Prevention
    NIH R01DE026644Jan 1, 2017 - Dec 31, 2021
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Faculty Mentoring

    Collapse Featured Content 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Focal Adhesion Kinase Fine Tunes Multifaced Signals toward Breast Cancer Progression. Cancers (Basel). 2021 Feb 05; 13(4). Rigiracciolo DC, Cirillo F, Talia M, Muglia L, Gutkind JS, Maggiolini M, Lappano R. PMID: 33562737.
      View in: PubMed   Mentions:
    2. mTOR inhibitor use in head and neck squamous cell carcinoma: A meta-analysis on survival, tumor response, and toxicity. Laryngoscope Investig Otolaryngol. 2020 Apr; 5(2):243-255. Patel J, Nguyen SA, Ogretmen B, Gutkind JS, Nathan CA, Day T. PMID: 32337356.
      View in: PubMed   Mentions:
    3. Targeting mTOR in Head and Neck Cancer-Response. Clin Cancer Res. 2019 11 01; 25(21):6555. Gutkind JS, Day TA, Lippman SM, Szabo E. PMID: 31676588.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis. Sci Rep. 2019 08 12; 9(1):11666. Zahra FT, Sajib MS, Ichiyama Y, Akwii RG, Tullar PE, Cobos C, Minchew SA, Doçi CL, Zheng Y, Kubota Y, Gutkind JS, Mikelis CM. PMID: 31406143.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    5. Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm. Oncogene. 2019 09; 38(38):6491-6506. Raimondi F, Inoue A, Kadji FMN, Shuai N, Gonzalez JC, Singh G, de la Vega AA, Sotillo R, Fischer B, Aoki J, Gutkind JS, Russell RB. PMID: 31337866.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. Beyond Synthetic Lethality: Charting the Landscape of Pairwise Gene Expression States Associated with Survival in Cancer. Cell Rep. 2019 07 23; 28(4):938-948.e6. Magen A, Das Sahu A, Lee JS, Sharmin M, Lugo A, Gutkind JS, Schäffer AA, Ruppin E, Hannenhalli S. PMID: 31340155.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    7. Metformin Inhibits Progression of Head and Neck Squamous Cell Carcinoma by Acting Directly on Carcinoma-Initiating Cells. Cancer Res. 2019 09 01; 79(17):4360-4370. Wu X, Yeerna H, Goto Y, Ando T, Wu VH, Zhang X, Wang Z, Amornphimoltham P, Murphy AN, Tamayo P, Chen Q, Lippman SM, Gutkind JS. PMID: 31292160.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    8. PRECOG: PREdicting COupling probabilities of G-protein coupled receptors. Nucleic Acids Res. 2019 07 02; 47(W1):W395-W401. Singh G, Inoue A, Gutkind JS, Russell RB, Raimondi F. PMID: 31143927.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. Illuminating the Onco-GPCRome: Novel G protein-coupled receptor-driven oncocrine networks and targets for cancer immunotherapy. J Biol Chem. 2019 07 19; 294(29):11062-11086. Wu V, Yeerna H, Nohata N, Chiou J, Harismendy O, Raimondi F, Inoue A, Russell RB, Tamayo P, Gutkind JS. PMID: 31171722.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    10. Correction to: mTOR co-targeting strategies for head and neck cancer therapy. Cancer Metastasis Rev. 2019 Jun; 38(1-2):327. Wang Z, Valera JC, Zhao X, Chen Q, Gutkind JS. PMID: 30187213.
      View in: PubMed   Mentions:    Fields:    
    11. Illuminating G-Protein-Coupling Selectivity of GPCRs. Cell. 2019 06 13; 177(7):1933-1947.e25. Inoue A, Raimondi F, Kadji FMN, Singh G, Kishi T, Uwamizu A, Ono Y, Shinjo Y, Ishida S, Arang N, Kawakami K, Gutkind JS, Aoki J, Russell RB. PMID: 31160049.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    12. 4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer. Cancer Res. 2019 04 01; 79(7):1438-1450. Wang Z, Feng X, Molinolo AA, Martin D, Vitale-Cross L, Nohata N, Ando M, Wahba A, Amornphimoltham P, Wu X, Gilardi M, Allevato M, Wu V, Steffen DJ, Tofilon P, Sonenberg N, Califano J, Chen Q, Lippman SM, Gutkind JS. PMID: 30894372.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    13. Direct targeting of Gaq and Ga11 oncoproteins in cancer cells. Sci Signal. 2019 03 19; 12(573). Annala S, Feng X, Shridhar N, Eryilmaz F, Patt J, Yang J, Pfeil EM, Cervantes-Villagrana RD, Inoue A, Häberlein F, Slodczyk T, Reher R, Kehraus S, Monteleone S, Schrage R, Heycke N, Rick U, Engel S, Pfeifer A, Kolb P, König G, Bünemann M, Tüting T, Vázquez-Prado J, Gutkind JS, Gaffal E, Kostenis E. PMID: 30890659.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    14. Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy. Mol Syst Biol. 2019 03 11; 15(3):e8323. Sahu AD, S Lee J, Wang Z, Zhang G, Iglesias-Bartolome R, Tian T, Wei Z, Miao B, Nair NU, Ponomarova O, Friedman AA, Amzallag A, Moll T, Kasumova G, Greninger P, Egan RK, Damon LJ, Frederick DT, Jerby-Arnon L, Wagner A, Cheng K, Park SG, Robinson W, Gardner K, Boland G, Hannenhalli S, Herlyn M, Benes C, Flaherty K, Luo J, Gutkind JS, Ruppin E. PMID: 30858180.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    15. Immune Modulation of Head and Neck Squamous Cell Carcinoma and the Tumor Microenvironment by Conventional Therapeutics. Clin Cancer Res. 2019 07 15; 25(14):4211-4223. Miyauchi S, Kim SS, Pang J, Gold KA, Gutkind JS, Califano JA, Mell LK, Cohen EEW, Sharabi AB. PMID: 30814108.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    16. Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential. Sci Signal. 2019 02 19; 12(569). Bandekar SJ, Arang N, Tully ES, Tang BA, Barton BL, Li S, Gutkind JS, Tesmer JJG. PMID: 30783010.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    17. SOX2 Epidermal Overexpression Promotes Cutaneous Wound Healing via Activation of EGFR/MEK/ERK Signaling Mediated by EGFR Ligands. J Invest Dermatol. 2019 08; 139(8):1809-1820.e8. Uchiyama A, Nayak S, Graf R, Cross M, Hasneen K, Gutkind JS, Brooks SR, Morasso MI. PMID: 30772301.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    18. A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK. Cancer Cell. 2019 03 18; 35(3):457-472.e5. Feng X, Arang N, Rigiracciolo DC, Lee JS, Yeerna H, Wang Z, Lubrano S, Kishore A, Pachter JA, König GM, Maggiolini M, Kostenis E, Schlaepfer DD, Tamayo P, Chen Q, Ruppin E, Gutkind JS. PMID: 30773340.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    19. cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits. J Biol Chem. 2019 02 15; 294(7):2232-2246. Adame-García SR, Cervantes-Villagrana RD, Orduña-Castillo LB, Del Rio JC, Gutkind JS, Reyes-Cruz G, Taylor SS, Vázquez-Prado J. PMID: 30530493.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    20. Gß? signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gaq and Ga13 proteins. J Biol Chem. 2019 01 11; 294(2):531-546. Cervantes-Villagrana RD, Adame-García SR, García-Jiménez I, Color-Aparicio VM, Beltrán-Navarro YM, König GM, Kostenis E, Reyes-Cruz G, Gutkind JS, Vázquez-Prado J. PMID: 30446620.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    21. Inhibition of mTOR Signaling and Clinical Activity of Rapamycin in Head and Neck Cancer in a Window of Opportunity Trial. Clin Cancer Res. 2019 02 15; 25(4):1156-1164. Day TA, Shirai K, O'Brien PE, Matheus MG, Godwin K, Sood AJ, Kompelli A, Vick JA, Martin D, Vitale-Cross L, Callejas-Varela JL, Wang Z, Wu X, Harismendy O, Molinolo AA, Lippman SM, Van Waes C, Szabo E, Gutkind JS. PMID: 30420444.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    22. Arrestins as rheostats of GPCR signalling. Nat Rev Mol Cell Biol. 2018 10; 19(10):615-616. Gutkind JS, Kostenis E. PMID: 30026541.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    23. Development of a yeast-based system to identify new hBRAFV600E functional interactors. Oncogene. 2019 02; 38(8):1355-1366. Lubrano S, Comelli L, Piccirilli C, Marranci A, Dapporto F, Tantillo E, Gemignani F, Gutkind JS, Salvetti A, Chiorino G, Cozza G, Chiariello M, Galli A, Poliseno L, Cervelli T. PMID: 30237439.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    24. GNASR201C Induces Pancreatic Cystic Neoplasms in Mice That Express Activated KRAS by Inhibiting YAP1 Signaling. Gastroenterology. 2018 11; 155(5):1593-1607.e12. Ideno N, Yamaguchi H, Ghosh B, Gupta S, Okumura T, Steffen DJ, Fisher CG, Wood LD, Singhi AD, Nakamura M, Gutkind JS, Maitra A. PMID: 30142336.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    25. Transcriptional signature primes human oral mucosa for rapid wound healing. Sci Transl Med. 2018 07 25; 10(451). Iglesias-Bartolome R, Uchiyama A, Molinolo AA, Abusleme L, Brooks SR, Callejas-Valera JL, Edwards D, Doci C, Asselin-Labat ML, Onaitis MW, Moutsopoulos NM, Gutkind JS, Morasso MI. PMID: 30045979.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    26. The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras. J Biol Chem. 2018 Jul 20; 293(29):11651. Oliva JL, Zarich N, Martínez N, Jorge R, Castrillo A, Azañedo M, García-Vargas S, Gutiérrez-Eisman S, Juarranz A, Boscá L, Gutkind JS, Rojas JM. PMID: 30030386.
      View in: PubMed   Mentions:    Fields:    
    27. Assembly and activation of the Hippo signalome by FAT1 tumor suppressor. Nat Commun. 2018 07 09; 9(1):2372. Martin D, Degese MS, Vitale-Cross L, Iglesias-Bartolome R, Valera JLC, Wang Z, Feng X, Yeerna H, Vadmal V, Moroishi T, Thorne RF, Zaida M, Siegele B, Cheong SC, Molinolo AA, Samuels Y, Tamayo P, Guan KL, Lippman SM, Lyons JG, Gutkind JS. PMID: 29985391.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    28. Head and Neck Cancer in the New Era of Precision Medicine. J Dent Res. 2018 06; 97(6):601-602. Nör JE, Gutkind JS. PMID: 29771196.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    29. GENIPAC: A Genomic Information Portal for Head and Neck Cancer Cell Systems. J Dent Res. 2018 07; 97(8):909-916. Lee BKB, Gan CP, Chang JK, Tan JL, Fadlullah MZ, Abdul Rahman ZA, Prime SS, Gutkind JS, Liew CS, Khang TF, Tan AC, Cheong SC. PMID: 29512401.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    30. The homozygous CX3CR1-M280 mutation impairs human monocyte survival. JCI Insight. 2018 02 08; 3(3). Collar AL, Swamydas M, O'Hayre M, Sajib MS, Hoffman KW, Singh SP, Mourad A, Johnson MD, Ferre EM, Farber JM, Lim JK, Mikelis CM, Gutkind JS, Lionakis MS. PMID: 29415879.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    31. Expression of an active Gas mutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance. Proc Natl Acad Sci U S A. 2018 01 16; 115(3):E428-E437. Zhao X, Deng P, Iglesias-Bartolome R, Amornphimoltham P, Steffen DJ, Jin Y, Molinolo AA, de Castro LF, Ovejero D, Yuan Q, Chen Q, Han X, Bai D, Taylor SS, Yang Y, Collins MT, Gutkind JS. PMID: 29282319.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    32. The NOTCH4-HEY1 Pathway Induces Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2018 02 01; 24(3):619-633. Fukusumi T, Guo TW, Sakai A, Ando M, Ren S, Haft S, Liu C, Amornphimoltham P, Gutkind JS, Califano JA. PMID: 29146722.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    33. The Next Frontier: Head and Neck Cancer Immunoprevention. Cancer Prev Res (Phila). 2017 Dec; 10(12):681-683. Gutkind JS, Bui JD. PMID: 29138137.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    34. Genetic variants affecting equivalent protein family positions reflect human diversity. Sci Rep. 2017 10 06; 7(1):12771. Raimondi F, Betts MJ, Lu Q, Inoue A, Gutkind JS, Russell RB. PMID: 28986545.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    35. A Novel Functional Splice Variant of AKT3 Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers. Cancer Res. 2017 10 01; 77(19):5248-5258. Guo T, Sakai A, Afsari B, Considine M, Danilova L, Favorov AV, Yegnasubramanian S, Kelley DZ, Flam E, Ha PK, Khan Z, Wheelan SJ, Gutkind JS, Fertig EJ, Gaykalova DA, Califano J. PMID: 28733453.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    36. Genetic evidence that ß-arrestins are dispensable for the initiation of ß2-adrenergic receptor signaling to ERK. Sci Signal. 2017 Jun 20; 10(484). O'Hayre M, Eichel K, Avino S, Zhao X, Steffen DJ, Feng X, Kawakami K, Aoki J, Messer K, Sunahara R, Inoue A, von Zastrow M, Gutkind JS. PMID: 28634209.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    37. E1a is an exogenous in vivo tumour suppressor. Cancer Lett. 2017 07 28; 399:74-81. Cimas FJ, Callejas-Valera JL, García-Olmo DC, Hernández-Losa J, Melgar-Rojas P, Ruiz-Hidalgo MJ, Pascual-Serra R, Ortega-Muelas M, Roche O, Marcos P, Garcia-Gil E, Fernandez-Aroca DM, Ramón Y Cajal S, Gutkind JS, Sanchez-Prieto R. PMID: 28416454.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    38. Epidermal loss of Gaq confers a migratory and differentiation defect in keratinocytes. PLoS One. 2017; 12(3):e0173692. Doçi CL, Mikelis CM, Callejas-Valera JL, Hansen KK, Molinolo AA, Inoue A, Offermanns S, Gutkind JS. PMID: 28301547.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    39. Integrative computational analysis of transcriptional and epigenetic alterations implicates DTX1 as a putative tumor suppressor gene in HNSCC. Oncotarget. 2017 Feb 28; 8(9):15349-15363. Gaykalova DA, Zizkova V, Guo T, Tiscareno I, Wei Y, Vatapalli R, Hennessey PT, Ahn J, Danilova L, Khan Z, Bishop JA, Gutkind JS, Koch WM, Westra WH, Fertig EJ, Ochs MF, Califano JA. PMID: 28146432.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    40. Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer. Cancer Discov. 2017 04; 7(4):410-423. Carter H, Marty R, Hofree M, Gross AM, Jensen J, Fisch KM, Wu X, DeBoever C, Van Nostrand EL, Song Y, Wheeler E, Kreisberg JF, Lippman SM, Yeo GW, Gutkind JS, Ideker T. PMID: 28188128.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    41. Using Heterologous COS-7 Cells to Identify Semaphorin-Signaling Components. Methods Mol Biol. 2017; 1493:163-170. Sakurai A, Doçi CL, Gutkind JS. PMID: 27787849.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    42. Onco-GPCR signaling and dysregulated expression of microRNAs in human cancer. J Hum Genet. 2017 Jan; 62(1):87-96. Nohata N, Goto Y, Gutkind JS. PMID: 27734836.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    43. LAG-3 confers poor prognosis and its blockade reshapes antitumor response in head and neck squamous cell carcinoma. Oncoimmunology. 2016; 5(11):e1239005. Deng WW, Mao L, Yu GT, Bu LL, Ma SR, Liu B, Gutkind JS, Kulkarni AB, Zhang WF, Sun ZJ. PMID: 27999760.
      View in: PubMed   Mentions:
    44. mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model. Carcinogenesis. 2016 10; 37(10):1014-25. Callejas-Valera JL, Iglesias-Bartolome R, Amornphimoltham P, Palacios-Garcia J, Martin D, Califano JA, Molinolo AA, Gutkind JS. PMID: 27538837.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    45. Unraveling the oral cancer lncRNAome: Identification of novel lncRNAs associated with malignant progression and HPV infection. Oral Oncol. 2016 08; 59:58-66. Nohata N, Abba MC, Gutkind JS. PMID: 27424183.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    46. Liver kinase B1 regulates hepatocellular tight junction distribution and function in vivo. Hepatology. 2016 10; 64(4):1317-29. Porat-Shliom N, Tietgens AJ, Van Itallie CM, Vitale-Cross L, Jarnik M, Harding OJ, Anderson JM, Gutkind JS, Weigert R, Arias IM. PMID: 27396550.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    47. Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer. Oncotarget. 2016 07 26; 7(30):47565-47575. Andradas C, Blasco-Benito S, Castillo-Lluva S, Dillenburg-Pilla P, Diez-Alarcia R, Juanes-García A, García-Taboada E, Hernando-Llorente R, Soriano J, Hamann S, Wenners A, Alkatout I, Klapper W, Rocken C, Bauer M, Arnold N, Quintanilla M, Megías D, Vicente-Manzanares M, Urigüen L, Gutkind JS, Guzmán M, Pérez-Gómez E, Sánchez C. PMID: 27340777.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    48. WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Ga12/13. Mol Pharmacol. 2016 10; 90(4):447-59. Arthofer E, Hot B, Petersen J, Strakova K, Jäger S, Grundmann M, Kostenis E, Gutkind JS, Schulte G. PMID: 27458145.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    49. PI3K pathway is involved in ERK signaling cascade activation by histamine H2R agonist in HEK293T cells. Biochim Biophys Acta. 2016 09; 1860(9):1998-2007. Alonso N, Diaz Nebreda A, Monczor F, Gutkind JS, Davio C, Fernandez N, Shayo C. PMID: 27316323.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    50. Phase II trial of everolimus in patients with previously treated recurrent or metastatic head and neck squamous cell carcinoma. Head Neck. 2016 12; 38(12):1759-1764. Geiger JL, Bauman JE, Gibson MK, Gooding WE, Varadarajan P, Kotsakis A, Martin D, Gutkind JS, Hedberg ML, Grandis JR, Argiris A. PMID: 27232378.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCTClinical Trials
    51. Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies. Oncotarget. 2016 May 10; 7(19):27802-18. Fadlullah MZ, Chiang IK, Dionne KR, Yee PS, Gan CP, Sam KK, Tiong KH, Ng AK, Martin D, Lim KP, Kallarakkal TG, Mustafa WM, Lau SH, Abraham MT, Zain RB, Rahman ZA, Molinolo A, Patel V, Gutkind JS, Tan AC, Cheong SC. PMID: 27050151.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    52. NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell. Sci Rep. 2016 04 25; 6:24704. Zhao ZL, Zhang L, Huang CF, Ma SR, Bu LL, Liu JF, Yu GT, Liu B, Gutkind JS, Kulkarni AB, Zhang WF, Sun ZJ. PMID: 27108536.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    53. Circulating Fibroblast Growth Factor-2, HIV-Tat, and Vascular Endothelial Cell Growth Factor-A in HIV-Infected Children with Renal Disease Activate Rho-A and Src in Cultured Renal Endothelial Cells. PLoS One. 2016; 11(4):e0153837. Das JR, Gutkind JS, Ray PE. PMID: 27097314.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    54. Prevention of irradiation-induced salivary hypofunction by rapamycin in swine parotid glands. Oncotarget. 2016 Apr 12; 7(15):20271-81. Zhu Z, Pang B, Iglesias-Bartolome R, Wu X, Hu L, Zhang C, Wang J, Gutkind JS, Wang S. PMID: 26958808.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    55. Signals and Receptors. Cold Spring Harb Perspect Biol. 2016 Apr 01; 8(4):a005900. Heldin CH, Lu B, Evans R, Gutkind JS. PMID: 27037414.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    56. A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers. Oncotarget. 2016 Mar 08; 7(10):10696-709. Yamaguchi K, Iglesias-Bartolomé R, Wang Z, Callejas-Valera JL, Amornphimoltham P, Molinolo AA, Cohen EE, Califano JA, Lippman SM, Luo J, Gutkind JS. PMID: 26882569.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    57. Combined image guided monitoring the pharmacokinetics of rapamycin loaded human serum albumin nanoparticles with a split luciferase reporter. Nanoscale. 2016 Feb 21; 8(7):3991-4000. Wang F, Yang K, Wang Z, Ma Y, Gutkind JS, Hida N, Niu G, Tian J. PMID: 26818100.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    58. Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis. Dev Biol. 2016 Mar 15; 411(2):183-194. Nohata N, Uchida Y, Stratman AN, Adams RH, Zheng Y, Weinstein BM, Mukouyama YS, Gutkind JS. PMID: 26872874.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    59. Erlotinib and the Risk of Oral Cancer: The Erlotinib Prevention of Oral Cancer (EPOC) Randomized Clinical Trial. JAMA Oncol. 2016 Feb; 2(2):209-16. William WN, Papadimitrakopoulou V, Lee JJ, Mao L, Cohen EE, Lin HY, Gillenwater AM, Martin JW, Lingen MW, Boyle JO, Shin DM, Vigneswaran N, Shinn N, Heymach JV, Wistuba II, Tang X, Kim ES, Saintigny P, Blair EA, Meiller T, Gutkind JS, Myers J, El-Naggar A, Lippman SM. PMID: 26540028.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    60. MKP1 mediates chemosensitizer effects of E1a in response to cisplatin in non-small cell lung carcinoma cells. Oncotarget. 2015 Dec 29; 6(42):44095-107. Cimas FJ, Callejas-Valera JL, Pascual-Serra R, García-Cano J, Garcia-Gil E, De la Cruz-Morcillo MA, Ortega-Muelas M, Serrano-Oviedo L, Gutkind JS, Sánchez-Prieto R. PMID: 26689986.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    61. PD-1 blockade attenuates immunosuppressive myeloid cells due to inhibition of CD47/SIRPa axis in HPV negative head and neck squamous cell carcinoma. Oncotarget. 2015 Dec 08; 6(39):42067-80. Yu GT, Bu LL, Huang CF, Zhang WF, Chen WJ, Gutkind JS, Kulkarni AB, Sun ZJ. PMID: 26573233.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    62. Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Ga13/RhoA axis in B cells. Oncogene. 2016 07 21; 35(29):3771-80. O'Hayre M, Inoue A, Kufareva I, Wang Z, Mikelis CM, Drummond RA, Avino S, Finkel K, Kalim KW, DiPasquale G, Guo F, Aoki J, Zheng Y, Lionakis MS, Molinolo AA, Gutkind JS. PMID: 26616858.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    63. Sonic Hedgehog in SCLC. Aging (Albany NY). 2015 Sep; 7(9):605-6. Laukkanen MO, Gutkind JS, Castellone MD. PMID: 26420823.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    64. Voltage-gated Na+ Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling. Sci Rep. 2015 Jun 22; 5:11541. House CD, Wang BD, Ceniccola K, Williams R, Simaan M, Olender J, Patel V, Baptista-Hon DT, Annunziata CM, Gutkind JS, Hales TG, Lee NH. PMID: 26096612.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    65. Polymeric Nanovehicle Regulated Spatiotemporal Real-Time Imaging of the Differentiation Dynamics of Transplanted Neural Stem Cells after Traumatic Brain Injury. ACS Nano. 2015 Jul 28; 9(7):6683-95. Wang Z, Wang Y, Wang Z, Zhao J, Gutkind JS, Srivatsan A, Zhang G, Liao HS, Fu X, Jin A, Tong X, Niu G, Chen X. PMID: 26020550.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    66. Inactivation of a Ga(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis. Nat Cell Biol. 2015 Jun; 17(6):793-803. Iglesias-Bartolome R, Torres D, Marone R, Feng X, Martin D, Simaan M, Chen M, Weinstein LS, Taylor SS, Molinolo AA, Gutkind JS. PMID: 25961504.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    67. Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma. Cancer Res. 2015 Jul 15; 75(14):2937-48. Doçi CL, Mikelis CM, Lionakis MS, Molinolo AA, Gutkind JS. PMID: 25952650.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    68. RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock. Nat Commun. 2015 Apr 10; 6:6725. Mikelis CM, Simaan M, Ando K, Fukuhara S, Sakurai A, Amornphimoltham P, Masedunskas A, Weigert R, Chavakis T, Adams RH, Offermanns S, Mochizuki N, Zheng Y, Gutkind JS. PMID: 25857352.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    69. An interplay between the p38 MAPK pathway and AUBPs regulates c-fos mRNA stability during mitogenic stimulation. Biochem J. 2015 Apr 01; 467(1):77-90. Degese MS, Tanos T, Naipauer J, Gingerich T, Chiappe D, Echeverria P, LaMarre J, Gutkind JS, Coso OA. PMID: 25588078.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    70. Levels of sirolimus in saliva and blood following oral topical sustained-release varnish delivery system application. Cancer Chemother Pharmacol. 2015 May; 75(5):969-74. Nudelman Z, Findler M, Barasch D, Nemirovski A, Pikovsky A, Kirmayer D, Basheer M, Gutkind JS, Friedman M, Czerninski R. PMID: 25757961.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    71. Prevention of tumor growth driven by PIK3CA and HPV oncogenes by targeting mTOR signaling with metformin in oral squamous carcinomas expressing OCT3. Cancer Prev Res (Phila). 2015 Mar; 8(3):197-207. Madera D, Vitale-Cross L, Martin D, Schneider A, Molinolo AA, Gangane N, Carey TE, McHugh JB, Komarck CM, Walline HM, William WN, Seethala RR, Ferris RL, Gutkind JS. PMID: 25681087.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    72. Fluorescent, bioactive protein nanoparticles (prodots) for rapid, improved cellular uptake. Bioconjug Chem. 2015 Mar 18; 26(3):396-404. Deshapriya IK, Stromer BS, Pattammattel A, Kim CS, Iglesias-Bartolome R, Gonzalez-Fajardo L, Patel V, Gutkind JS, Lu X, Kumar CV. PMID: 25642999.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    73. Engineered mesenchymal stem cells with enhanced tropism and paracrine secretion of cytokines and growth factors to treat traumatic brain injury. Stem Cells. 2015 Feb; 33(2):456-67. Wang Z, Wang Y, Wang Z, Gutkind JS, Wang Z, Wang F, Lu J, Niu G, Teng G, Chen X. PMID: 25346537.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    74. SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gai/mTORC1 axis. FASEB J. 2015 Mar; 29(3):1056-68. Dillenburg-Pilla P, Patel V, Mikelis CM, Zárate-Bladés CR, Doçi CL, Amornphimoltham P, Wang Z, Martin D, Leelahavanichkul K, Dorsam RT, Masedunskas A, Weigert R, Molinolo AA, Gutkind JS. PMID: 25466898.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    75. Oncotargeting G proteins: The Hippo in the room. Oncotarget. 2014 Nov 30; 5(22):10997-9. Feng X, Chen Q, Gutkind JS. PMID: 25526026.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    76. A systems genetics approach identifies CXCL14, ITGAX, and LPCAT2 as novel aggressive prostate cancer susceptibility genes. PLoS Genet. 2014 Nov; 10(11):e1004809. Williams KA, Lee M, Hu Y, Andreas J, Patel SJ, Zhang S, Chines P, Elkahloun A, Chandrasekharappa S, Gutkind JS, Molinolo AA, Crawford NP. PMID: 25411967.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    77. Heterotrimeric G-protein alpha-12 (Ga12) subunit promotes oral cancer metastasis. Oncotarget. 2014 Oct 30; 5(20):9626-40. Gan CP, Patel V, Mikelis CM, Zain RB, Molinolo AA, Abraham MT, Teo SH, Abdul Rahman ZA, Gutkind JS, Cheong SC. PMID: 25275299.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    78. The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies. Oncotarget. 2014 Oct 15; 5(19):8906-23. Martin D, Abba MC, Molinolo AA, Vitale-Cross L, Wang Z, Zaida M, Delic NC, Samuels Y, Lyons JG, Gutkind JS. PMID: 25275298.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    79. Cholecystokinin receptor antagonist halts progression of pancreatic cancer precursor lesions and fibrosis in mice. Pancreas. 2014 Oct; 43(7):1050-9. Smith JP, Cooper TK, McGovern CO, Gilius EL, Zhong Q, Liao J, Molinolo AA, Gutkind JS, Matters GL. PMID: 25058882.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    80. Insights into ß2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3. Protein Sci. 2014 Dec; 23(12):1708-16. Qi S, O'Hayre M, Gutkind JS, Hurley JH. PMID: 25220262.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    81. Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway. Oncogene. 2015 Jul; 34(27):3536-46. Liu G, Yu FX, Kim YC, Meng Z, Naipauer J, Looney DJ, Liu X, Gutkind JS, Mesri EA, Guan KL. PMID: 25195862.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    82. Biology of advanced uveal melanoma and next steps for clinical therapeutics. Pigment Cell Melanoma Res. 2015 Mar; 28(2):135-47. Luke JJ, Triozzi PL, McKenna KC, Van Meir EG, Gershenwald JE, Bastian BC, Gutkind JS, Bowcock AM, Streicher HZ, Patel PM, Sato T, Sossman JA, Sznol M, Welch J, Thurin M, Selig S, Flaherty KT, Carvajal RD. PMID: 25113308.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    83. mTOR co-targeting in cetuximab resistance in head and neck cancers harboring PIK3CA and RAS mutations. J Natl Cancer Inst. 2014 Sep; 106(9). Wang Z, Martin D, Molinolo AA, Patel V, Iglesias-Bartolome R, Degese MS, Vitale-Cross L, Chen Q, Gutkind JS. PMID: 25099740.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    84. Melanoma cell lysate induces CCR7 expression and in vivo migration to draining lymph nodes of therapeutic human dendritic cells. Immunology. 2014 Jul; 142(3):396-405. González FE, Ortiz C, Reyes M, Dutzan N, Patel V, Pereda C, Gleisner MA, López MN, Gutkind JS, Salazar-Onfray F. PMID: 24673602.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    85. Dermatomyositis paraneoplastic syndrome before symptomatic tonsillar squamous cell carcinoma: a case report. Head Neck. 2015 Jan; 37(1):E1-3. Adi AH, Alturkmani H, Spock T, Williams Yohannes P, Wargo S, Szabo E, Gutkind JS, Van Waes C. PMID: 24715579.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    86. Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. Cancer Cell. 2014 Jun 16; 25(6):831-45. Feng X, Degese MS, Iglesias-Bartolome R, Vaque JP, Molinolo AA, Rodrigues M, Zaidi MR, Ksander BR, Merlino G, Sodhi A, Chen Q, Gutkind JS. PMID: 24882515.
      View in: PubMed   Mentions: 190     Fields:    Translation:HumansAnimalsCells
    87. Cross talk between the bombesin neuropeptide receptor and Sonic hedgehog pathways in small cell lung carcinoma. Oncogene. 2015 Mar 26; 34(13):1679-87. Castellone MD, Laukkanen MO, Teramoto H, Bellelli R, Alì G, Fontanini G, Santoro M, Gutkind JS. PMID: 24747971.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    88. Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation. J Invest Dermatol. 2014 Sep; 134(9):2390-2398. Prickett TD, Zerlanko BJ, Hill VK, Gartner JJ, Qutob N, Jiang J, Simaan M, Wunderlich J, Gutkind JS, Rosenberg SA, Samuels Y. PMID: 24739903.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    89. Targeted therapeutic nanotubes influence the viscoelasticity of cancer cells to overcome drug resistance. ACS Nano. 2014 May 27; 8(5):4177-89. Bhirde AA, Chikkaveeraiah BV, Srivatsan A, Niu G, Jin AJ, Kapoor A, Wang Z, Patel S, Patel V, Gorbach AM, Leapman RD, Gutkind JS, Hight Walker AR, Chen X. PMID: 24708375.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    90. Levels of sirolimus in saliva and blood following mouthwash application. Oral Dis. 2014 Nov; 20(8):768-72. Nudelman Z, Friedman M, Barasch D, Nemirovski A, Findler M, Pikovsky A, Gutkind J, Czerninski R. PMID: 24548545.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    91. LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes. PLoS One. 2014; 9(3):e91921. Homolya L, Fu D, Sengupta P, Jarnik M, Gillet JP, Vitale-Cross L, Gutkind JS, Lippincott-Schwartz J, Arias IM. PMID: 24643070.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    92. The basic domain of HIV-tat transactivating protein is essential for its targeting to lipid rafts and regulating fibroblast growth factor-2 signaling in podocytes isolated from children with HIV-1-associated nephropathy. J Am Soc Nephrol. 2014 Aug; 25(8):1800-13. Xie X, Colberg-Poley AM, Das JR, Li J, Zhang A, Tang P, Jerebtsova M, Gutkind JS, Ray PE. PMID: 24578133.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    93. Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models. Mol Cancer. 2014 Feb 20; 13:32. Sobral LM, Sousa LO, Coletta RD, Cabral H, Greene LJ, Tajara EH, Gutkind JS, Curti C, Leopoldino AM. PMID: 24555657.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    94. Brag2 differentially regulates ß1- and ß3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis. Basic Res Cardiol. 2014 Mar; 109(2):404. Manavski Y, Carmona G, Bennewitz K, Tang Z, Zhang F, Sakurai A, Zeiher AM, Gutkind JS, Li X, Kroll J, Dimmeler S, Chavakis E. PMID: 24522833.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    95. Novel insights into G protein and G protein-coupled receptor signaling in cancer. Curr Opin Cell Biol. 2014 Apr; 27:126-35. O'Hayre M, Degese MS, Gutkind JS. PMID: 24508914.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    96. Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis. Oncogene. 2015 Jan 15; 34(3):346-56. Sales KU, Friis S, Konkel JE, Godiksen S, Hatakeyama M, Hansen KK, Rogatto SR, Szabo R, Vogel LK, Chen W, Gutkind JS, Bugge TH. PMID: 24469043.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    97. Structural and biochemical basis for ubiquitin ligase recruitment by arrestin-related domain-containing protein-3 (ARRDC3). J Biol Chem. 2014 Feb 21; 289(8):4743-52. Qi S, O'Hayre M, Gutkind JS, Hurley JH. PMID: 24379409.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    98. Impairing squamous differentiation by Klf4 deletion is sufficient to initiate tongue carcinoma development upon K-Ras activation in mice. Carcinogenesis. 2014 Mar; 35(3):662-9. Abrigo M, Alvarez R, Paparella ML, Calb DE, Bal de Kier Joffe E, Gutkind JS, Raimondi AR. PMID: 24148820.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    99. Massively parallel sequencing reveals an accumulation of de novo mutations and an activating mutation of LPAR1 in a patient with metastatic neuroblastoma. PLoS One. 2013; 8(10):e77731. Wei JS, Johansson P, Chen L, Song YK, Tolman C, Li S, Hurd L, Patidar R, Wen X, Badgett TC, Cheuk AT, Marshall JC, Steeg PS, Vaqué Díez JP, Yu Y, Gutkind JS, Khan J. PMID: 24147068.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    100. A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesis. Mol Oncol. 2014 Feb; 8(1):105-18. Leelahavanichkul K, Amornphimoltham P, Molinolo AA, Basile JR, Koontongkaew S, Gutkind JS. PMID: 24216180.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    101. Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study. J Biol Chem. 2013 Nov 22; 288(47):34030-34040. Artamonov MV, Momotani K, Stevenson A, Trentham DR, Derewenda U, Derewenda ZS, Read PW, Gutkind JS, Somlyo AV. PMID: 24106280.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    102. Exploiting the head and neck cancer oncogenome: widespread PI3K-mTOR pathway alterations and novel molecular targets. Cancer Discov. 2013 Jul; 3(7):722-5. Iglesias-Bartolome R, Martin D, Gutkind JS. PMID: 23847349.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    103. IKK epsilon kinase is crucial for viral G protein-coupled receptor tumorigenesis. Proc Natl Acad Sci U S A. 2013 Jul 02; 110(27):11139-44. Wang Y, Lu X, Zhu L, Shen Y, Chengedza S, Feng H, Wang L, Jung JU, Gutkind JS, Gutkind JS, Feng P. PMID: 23771900.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    104. Rapid microfluidic immunoassays of cancer biomarker proteins using disposable inkjet-printed gold nanoparticle arrays. ChemistryOpen. 2013 Aug; 2(4):141-5. Krause CE, Otieno BA, Latus A, Faria RC, Patel V, Gutkind JS, Rusling JF. PMID: 24482763.
      View in: PubMed   Mentions:
    105. Improved clearance during treatment of HPV-positive head and neck cancer through mTOR inhibition. Neoplasia. 2013 Jun; 15(6):620-30. Coppock JD, Wieking BG, Molinolo AA, Gutkind JS, Miskimins WK, Lee JH. PMID: 23730210.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    106. Accumulation of dephosphorylated 4EBP after mTOR inhibition with rapamycin is sufficient to disrupt paracrine transformation by the KSHV vGPCR oncogene. Oncogene. 2014 May 01; 33(18):2405-12. Martin D, Nguyen Q, Molinolo A, Gutkind JS. PMID: 23708663.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    107. The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. Nat Rev Cancer. 2013 06; 13(6):412-24. O'Hayre M, Vázquez-Prado J, Kufareva I, Stawiski EW, Handel TM, Seshagiri S, Gutkind JS. PMID: 23640210.
      View in: PubMed   Mentions: 192     Fields:    Translation:HumansAnimalsCells
    108. Germline genetic variation modulates tumor progression and metastasis in a mouse model of neuroendocrine prostate carcinoma. PLoS One. 2013; 8(4):e61848. Patel SJ, Molinolo AA, Gutkind S, Crawford NP. PMID: 23620793.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    109. Epigenetics, noncoding RNAs, and cell signaling--crossroads in the regulation of cell fate decisions. Curr Opin Cell Biol. 2013 Apr; 25(2):149-51. Blelloch R, Gutkind JS. PMID: 23498659.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    110. Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis. Nat Med. 2013 Apr; 19(4):421-8. Han G, Bian L, Li F, Cotrim A, Wang D, Lu J, Deng Y, Bird G, Sowers A, Mitchell JB, Gutkind JS, Zhao R, Raben D, ten Dijke P, Refaeli Y, Zhang Q, Wang XJ. PMID: 23475202.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCellsPHPublic Health
    111. Cross-desensitization and cointernalization of H1 and H2 histamine receptors reveal new insights into histamine signal integration. Mol Pharmacol. 2013 May; 83(5):1087-98. Alonso N, Fernandez N, Notcovich C, Monczor F, Simaan M, Baldi A, Gutkind JS, Davio C, Shayo C. PMID: 23462507.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    112. Heparin inhibits angiotensin II-induced vasoconstriction on isolated mouse mesenteric resistance arteries through Rho-A- and PKA-dependent pathways. Vascul Pharmacol. 2013 Apr; 58(4):313-8. Xie-Zukauskas H, Das J, Short BL, Gutkind JS, Ray PE. PMID: 23268358.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    113. SET overexpression decreases cell detoxification efficiency: ALDH2 and GSTP1 are downregulated, DDR is impaired and DNA damage accumulates. FEBS J. 2012 Dec; 279(24):4615-28. Almeida LO, Goto RN, Pestana CR, Uyemura SA, Gutkind S, Curti C, Leopoldino AM. PMID: 23106910.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    114. Molecular mechanisms deployed by virally encoded G protein-coupled receptors in human diseases. Annu Rev Pharmacol Toxicol. 2013; 53:331-54. Montaner S, Kufareva I, Abagyan R, Gutkind JS. PMID: 23092247.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    115. Ultrasensitive detection of cancer biomarkers in the clinic by use of a nanostructured microfluidic array. Anal Chem. 2012 Jul 17; 84(14):6249-55. Malhotra R, Patel V, Chikkaveeraiah BV, Munge BS, Cheong SC, Zain RB, Abraham MT, Dey DK, Gutkind JS, Rusling JF. PMID: 22697359.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimals
    116. Receptor tyrosine kinases activate canonical WNT/ß-catenin signaling via MAP kinase/LRP6 pathway and direct ß-catenin phosphorylation. PLoS One. 2012; 7(4):e35826. Krejci P, Aklian A, Kaucka M, Sevcikova E, Prochazkova J, Masek JK, Mikolka P, Pospisilova T, Spoustova T, Weis M, Paznekas WA, Wolf JH, Gutkind JS, Wilcox WR, Kozubik A, Jabs EW, Bryja V, Salazar L, Vesela I, Balek L. PMID: 22558232.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    117. Oncogene-induced senescence results in marked metabolic and bioenergetic alterations. . 2012 Apr 01; 11(7):1383-92. Quijano C, Cao L, Fergusson MM, Romero H, Liu J, Gutkind S, Rovira II, Mohney RP, Karoly ED, Finkel T. PMID: 22421146.
      View in: PubMed   Mentions:
    118. Interleukin-21 expression and its association with proinflammatory cytokines in untreated chronic periodontitis patients. J Periodontol. 2012 Jul; 83(7):948-54. Dutzan N, Vernal R, Vaque JP, García-Sesnich J, Hernandez M, Abusleme L, Dezerega A, Gutkind JS, Gamonal J. PMID: 22181687.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCellsPHPublic Health
    119. Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma. Neoplasia. 2006 Sep; 8(9):733-46. Squarize CH, Castilho RM, Sriuranpong V, Pinto DS, Gutkind JS. PMID: 16984731.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
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