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Catriona Jamieson

Title(s)Professor, Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0695
La Jolla CA 92093
Phone858-534-7128
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    Collapse Biography 
    Collapse Awards and Honors
    UC San Diego Moores Cancer Center2020Rell Sunn Award
    CURE Media Group2017MPN Heroes Award
    UC San Diego2017Koman Family Presidential Endowed Chair in Cancer Research
    UC San Diego2016Chancellor’s Excellence in Stewardship Award

    Collapse Overview 
    Collapse Overview
    Research Interests
    Dr. Jamieson specialized in myeloproliferative disorders (MPDs) and leukemia. Myeloproliferative neoplasms are a family of uncommon but not rare degenerative disorders in which the body overproduces blood cells. Myeloproliferative neoplasms can cause many forms of blood clotting including heart attack, stroke, deep venous thrombosis, and pulmonary emboli and can develop into acute myelogenous leukemia. Although some effective treatments are available, they are laden with serious side effects. In addition, individuals can become resistant to the treatments. Dr. Jamieson studies the mutant stem cells and progenitor cells in myeloproliferative neoplasms. These cells can give rise to cancer stem cells. Cancer stem cells may lie low to evade chemotherapy and then activate again later, causing disease progression and resistance to treatment. Her goal is to find more selective, less toxic therapies. In the past two years, Dr. Jamieson’s stem-cell research studies have taken a great leap: from identifying a promising treatment in the laboratory to opening and completing the first clinical trial to target cancer stem cells in humans. This trial is the result of teamwork that has brought together her discoveries in myeloproliferative neoplasms and a local pharmaceutical company’s drug development track.

    Education and Training
    BS - Biology-Genetics, University of British Columbia - 1987
    Ph.D. - Microbiology, University of British Columbia - 1992
    MD - University of British Columbia - 1995
    Resident - University of British Columbia - 1995-1998
    Fellow, Bone Marrow Transplant - University of British Columbia - 1998
    Fellow, Bone Marrow Transplant - Stanford University - 1999-2002
    Postdoctoral Research Fellow - Stanford University - 2002-2005

    Collapse Research 
    Collapse Research Activities and Funding
    Development of An Orbital Laboratory to Advance Regenerative Medicine and Stem Cell Therapies
    Space Tango Jun 1, 2020 - May 31, 2023
    Role: Principal Investigator
    Detection and Targeting of Enzymatic Base Editing Deregulation in Leukemia Stem Cells
    The Leukemia & Lymphoma Society BCDG 8020-20Apr 1, 2020 - Mar 31, 2023
    Role: Principal Investigator
    Detection and Inhibition of Malignant RNA Processing Deregulation in Myelofibrosis
    The Leukemia & Lymphoma Society MPN Research FoundationNov 1, 2019 - Oct 31, 2021
    Role: Principal Investigator
    Defining the Niche-dependent Role of RNA Editing in Aged and MDS Hematopoietic Stem and Progenitor Cell Dysfunction
    NIH/NIDDK R01DK114468Aug 20, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Characterization of the Role of ADAR1 in Oncogenic Transformation of Progenitors
    NIH/NCI R01CA205944Dec 8, 2016 - Nov 30, 2021
    Role: Principal Investigator
    (PQC2) Niche-responsive RNA editing by ADAR1 in dormant multiple myeloma initiating cell maintenance
    NIH/NCI R21CA194679May 1, 2015 - Apr 30, 2017
    Role: Principal Investigator
    Identifying microRNA Targets for Early Detection of Myeloproliferative Neoplasms
    NIH/NCI R21CA189705Apr 1, 2015 - Mar 31, 2017
    Role: Principal Investigator
    2009 Stem Cells and Cancer Gordon Conference
    NIH/NCI R13CA139606Sep 1, 2009 - Aug 31, 2010
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Myeloid/Lymphoid Neoplasms with Eosinophilia and TK Fusion Genes, Version 3.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2020 Sep; 18(9):1248-1269. Gerds AT, Gotlib J, Bose P, Deininger MW, Dunbar A, Elshoury A, George TI, Gojo I, Gundabolu K, Hexner E, Hobbs G, Jain T, Jamieson C, Kuykendall AT, McMahon B, Mohan SR, Oehler V, Oh S, Pardanani A, Podoltsev N, Ranheim E, Rein L, Salit R, Snyder DS, Stein BL, Talpaz M, Thota S, Vachhani P, Wadleigh M, Walsh K, Ward DC, Bergman MA, Sundar H. PMID: 32886902.
      View in: PubMed   Mentions:    Fields:    
    2. Post-Transcriptional Regulation of Homeostatic, Stressed, and Malignant Stem Cells. Cell Stem Cell. 2020 02 06; 26(2):138-159. Chua BA, Van Der Werf I, Jamieson C, Signer RAJ. PMID: 32032524.
      View in: PubMed   Mentions: 1     Fields:    
    3. Hippo kinase loss contributes to del(20q) hematologic malignancies through chronic innate immune activation. Blood. 2019 11 14; 134(20):1730-1744. Stoner SA, Yan M, Liu KTH, Arimoto KI, Shima T, Wang HY, Johnson DT, Bejar R, Jamieson C, Guan KL, Zhang DE. PMID: 31434702.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. A-to-I RNA editing in leukemia stem cells - set ADAR1 on the radar. Oncotarget. 2019 Oct 22; 10(58):6047-6048. Jiang Q, Diep R, Jamieson C. PMID: 31692993.
      View in: PubMed   Mentions:    Fields:    
    5. To PARP or not to PARP?-Toward sensitizing acute myeloid leukemia stem cells to immunotherapy. EMBO J. 2019 10 04; 38(21):e103479. Heyman B, Jamieson C. PMID: 31633196.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. Cirmtuzumab blocks Wnt5a/ROR1 stimulation of NF-?B to repress autocrine STAT3 activation in chronic lymphocytic leukemia. Blood. 2019 09 26; 134(13):1084-1094. Chen Y, Chen L, Yu J, Ghia EM, Choi MY, Zhang L, Zhang S, Sanchez-Lopez E, Widhopf GF, Messer K, Rassenti LZ, Jamieson C, Kipps TJ. PMID: 31409670.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Corrigendum to "Phase 1/2 trial of glasdegib in patients with primary or secondary myelofibrosis previously treated with ruxolitinib" [Leukemia Res. 79 (2019) 38-44]. Leuk Res. 2019 Jun; 81:105. Gerds AT, Tauchi T, Ritchie E, Deininger M, Jamieson C, Mesa R, Heaney M, Komatsu N, Minami H, Su Y, Shaik N, Zhang X, DiRienzo C, Zeremski M, Chan G, Talpaz M. PMID: 31029462.
      View in: PubMed   Mentions:    Fields:    
    8. The Yin and Yang of RNA Methylation: An Imbalance of Erasers Enhances Sensitivity to FTO Demethylase Small-Molecule Targeting in Leukemia Stem Cells. Cancer Cell. 2019 04 15; 35(4):540-541. Van Der Werf I, Jamieson C. PMID: 30991023.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Phase 1/2 trial of glasdegib in patients with primary or secondary myelofibrosis previously treated with ruxolitinib. Leuk Res. 2019 04; 79:38-44. Gerds AT, Tauchi T, Ritchie E, Deininger M, Jamieson C, Mesa R, Heaney M, Komatsu N, Minami H, Su Y, Shaik N, Zhang X, DiRienzo C, Zeremski M, Chan G, Talpaz M. PMID: 30849661.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    10. Hyper-Editing of Cell-Cycle Regulatory and Tumor Suppressor RNA Promotes Malignant Progenitor Propagation. Cancer Cell. 2019 01 14; 35(1):81-94.e7. Jiang Q, Isquith J, Zipeto MA, Diep RH, Pham J, Delos Santos N, Reynoso E, Chau J, Leu H, Lazzari E, Melese E, Ma W, Fang R, Minden M, Morris S, Ren B, Pineda G, Holm F, Jamieson C. PMID: 30612940.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. Comprehensive Genomic Profiling Reveals Diverse but Actionable Molecular Portfolios across Hematologic Malignancies: Implications for Next Generation Clinical Trials. Cancers (Basel). 2018 Dec 21; 11(1). Galanina N, Bejar R, Choi M, Goodman A, Wieduwilt M, Mulroney C, Kim L, Yeerna H, Tamayo P, Vergilio JA, Mughal TI, Miller V, Jamieson C, Kurzrock R. PMID: 30583461.
      View in: PubMed   Mentions:
    12. Systemic Mastocytosis, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2018 12; 16(12):1500-1537. Gotlib J, Gerds AT, Bose P, Castells MC, Deininger MW, Gojo I, Gundabolu K, Hobbs G, Jamieson C, McMahon B, Mohan SR, Oehler V, Oh S, Padron E, Pancari P, Papadantonakis N, Pardanani A, Podoltsev N, Rampal R, Ranheim E, Rein L, Snyder DS, Stein BL, Talpaz M, Thota S, Wadleigh M, Walsh K, Bergman MA, Sundar H. PMID: 30545997.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. Phase I Trial: Cirmtuzumab Inhibits ROR1 Signaling and Stemness Signatures in Patients with Chronic Lymphocytic Leukemia. Cell Stem Cell. 2018 Jun 01; 22(6):951-959.e3. Choi MY, Widhopf GF, Ghia EM, Kidwell RL, Hasan MK, Yu J, Rassenti LZ, Chen L, Chen Y, Pittman E, Pu M, Messer K, Prussak CE, Castro JE, Jamieson C, Kipps TJ. PMID: 29859176.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCellsCTClinical Trials
    14. A First-in-Human, Phase I Study of Neural Stem Cell Transplantation for Chronic Spinal Cord Injury. Cell Stem Cell. 2018 Jun 01; 22(6):941-950.e6. Curtis E, Martin JR, Gabel B, Sidhu N, Rzesiewicz TK, Mandeville R, Van Gorp S, Leerink M, Tadokoro T, Marsala S, Jamieson C, Marsala M, Ciacci JD. PMID: 29859175.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    15. CIRM Alpha Stem Cell Clinics: Collaboratively Addressing Regenerative Medicine Challenges. Cell Stem Cell. 2018 06 01; 22(6):801-805. Jamieson CHM, Millan MT, Creasey AA, Lomax G, Donohoe ME, Walters MC, Abedi M, Bota DA, Zaia JA, Adams JS. PMID: 29859170.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    16. The Challenges of First-in-Human Stem Cell Clinical Trials: What Does This Mean for Ethics and Institutional Review Boards? Stem Cell Reports. 2018 May 08; 10(5):1429-1431. Barker RA, Carpenter MK, Forbes S, Goldman SA, Jamieson C, Murry CE, Takahashi J, Weir G. PMID: 29742388.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    17. Pacritinib vs Best Available Therapy, Including Ruxolitinib, in Patients With Myelofibrosis: A Randomized Clinical Trial. JAMA Oncol. 2018 05 01; 4(5):652-659. Mascarenhas J, Hoffman R, Talpaz M, Gerds AT, Stein B, Gupta V, Szoke A, Drummond M, Pristupa A, Granston T, Daly R, Al-Fayoumi S, Callahan JA, Singer JW, Gotlib J, Jamieson C, Harrison C, Mesa R, Verstovsek S. PMID: 29522138.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    18. BET'ing on Dual JAK/BET Inhibition as a Therapeutic Strategy for Myeloproliferative Neoplasms. Cancer Cell. 2018 01 08; 33(1):3-5. Jiang Q, Jamieson C. PMID: 29316431.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    19. Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma. Nat Commun. 2017 12 04; 8(1):1922. Lazzari E, Mondala PK, Santos ND, Miller AC, Pineda G, Jiang Q, Leu H, Ali SA, Ganesan AP, Wu CN, Costello C, Minden M, Chiaramonte R, Stewart AK, Crews LA, Jamieson CHM. PMID: 29203771.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    20. NCCN Guidelines Insights: Myeloproliferative Neoplasms, Version 2.2018. J Natl Compr Canc Netw. 2017 10; 15(10):1193-1207. Mesa RA, Jamieson C, Bhatia R, Deininger MW, Fletcher CD, Gerds AT, Gojo I, Gotlib J, Gundabolu K, Hobbs G, McMahon B, Mohan SR, Oh S, Padron E, Papadantonakis N, Pancari P, Podoltsev N, Rampal R, Ranheim E, Reddy V, Rein LAM, Scott B, Snyder DS, Stein BL, Talpaz M, Verstovsek S, Wadleigh M, Wang ES, Bergman MA, Gregory KM, Sundar H. PMID: 28982745.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    21. Cancer: Bad blood promotes tumour progression. Nature. 2017 09 27; 549(7673):465-466. Jamieson C. PMID: 28959960.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    22. RNA editing-dependent epitranscriptome diversity in cancer stem cells. Nat Rev Cancer. 2017 06; 17(6):381-392. Jiang Q, Crews LA, Holm F, Jamieson CHM. PMID: 28416802.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    23. Myeloproliferative Neoplasms, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2016 12; 14(12):1572-1611. Mesa R, Jamieson C, Bhatia R, Deininger MW, Gerds AT, Gojo I, Gotlib J, Gundabolu K, Hobbs G, Klisovic RB, Kropf P, Mohan SR, Oh S, Padron E, Podoltsev N, Pollyea DA, Rampal R, Rein LA, Scott B, Snyder DS, Stein BL, Verstovsek S, Wadleigh M, Wang ES, Bergman MA, Gregory KM, Sundar H. PMID: 27956542.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    24. Thoracic Extramedullary Hematopoiesis Mimicking Metastatic Cancer. J Bronchology Interv Pulmonol. 2016 Oct; 23(4):343-346. Ha D, Liao X, Wang HY, Jamieson C, Magaña M, Makani S. PMID: 27479013.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Specific bone region localization of osteolytic versus osteoblastic lesions in a patient-derived xenograft model of bone metastatic prostate cancer. Asian J Urol. 2016 Oct; 3(4):229-239. Hirata T, Park SC, Muldong MT, Wu CN, Yamaguchi T, Strasner A, Raheem O, Kumon H, Sah RL, Cacalano NA, Jamieson CHM, Kane CJ, Masuda K, Kulidjian AA, Jamieson CAM. PMID: 29264191.
      View in: PubMed   Mentions:
    26. Multiple myeloma-derived Jagged ligands increases autocrine and paracrine interleukin-6 expression in bone marrow niche. Oncotarget. 2016 Aug 30; 7(35):56013-56029. Colombo M, Galletti S, Bulfamante G, Falleni M, Tosi D, Todoerti K, Lazzari E, Crews LA, Jamieson CH, Ravaioli S, Baccianti F, Garavelli S, Platonova N, Neri A, Chiaramonte R. PMID: 27463014.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    27. RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML. Cell Stem Cell. 2016 11 03; 19(5):599-612. Crews LA, Balaian L, Delos Santos NP, Leu HS, Court AC, Lazzari E, Sadarangani A, Zipeto MA, La Clair JJ, Villa R, Kulidjian A, Storb R, Morris SR, Ball ED, Burkart MD, Jamieson CHM. PMID: 27570067.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    28. A phase I, open-label, dose-escalation, multicenter study of the JAK2 inhibitor NS-018 in patients with myelofibrosis. Leukemia. 2017 02; 31(2):393-402. Verstovsek S, Talpaz M, Ritchie E, Wadleigh M, Odenike O, Jamieson C, Stein B, Uno T, Mesa RA. PMID: 27479177.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    29. ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis. Cell Stem Cell. 2016 08 04; 19(2):177-191. Zipeto MA, Court AC, Sadarangani A, Delos Santos NP, Balaian L, Chun HJ, Pineda G, Morris SR, Mason CN, Geron I, Barrett C, Goff DJ, Wall R, Pellecchia M, Minden M, Frazer KA, Marra MA, Crews LA, Jiang Q, Jamieson CHM. PMID: 27292188.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    30. Tracking of Normal and Malignant Progenitor Cell Cycle Transit in a Defined Niche. Sci Rep. 2016 Apr 04; 6:23885. Pineda G, Lennon KM, Delos Santos NP, Lambert-Fliszar F, Riso GL, Lazzari E, Marra MA, Morris S, Sakaue-Sawano A, Miyawaki A, Jamieson CH. PMID: 27041210.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    31. Reversion to an embryonic alternative splicing program enhances leukemia stem cell self-renewal. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15444-9. Holm F, Hellqvist E, Mason CN, Ali SA, Delos-Santos N, Barrett CL, Chun HJ, Minden MD, Moore RA, Marra MA, Runza V, Frazer KA, Sadarangani A, Jamieson CH. PMID: 26621726.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    32. Effect of treatment with a JAK2-selective inhibitor, fedratinib, on bone marrow fibrosis in patients with myelofibrosis. J Transl Med. 2015 Sep 10; 13:294. Jamieson C, Hasserjian R, Gotlib J, Cortes J, Stone R, Talpaz M, Thiele J, Rodig S, Pozdnyakova O. PMID: 26357842.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCellsCTClinical Trials
    33. RNA rewriting, recoding, and rewiring in human disease. Trends Mol Med. 2015 Sep; 21(9):549-59. Zipeto MA, Jiang Q, Melese E, Jamieson CH. PMID: 26259769.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    34. A phase 2 randomized dose-ranging study of the JAK2-selective inhibitor fedratinib (SAR302503) in patients with myelofibrosis. Blood Cancer J. 2015 Aug 07; 5:e335. Pardanani A, Tefferi A, Jamieson C, Gabrail NY, Lebedinsky C, Gao G, Liu F, Xu C, Cao H, Talpaz M. PMID: 26252788.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    35. Treatment with PF-04449913, an oral smoothened antagonist, in patients with myeloid malignancies: a phase 1 safety and pharmacokinetics study. Lancet Haematol. 2015 Aug; 2(8):e339-46. Martinelli G, Oehler VG, Papayannidis C, Courtney R, Shaik MN, Zhang X, O'Connell A, McLachlan KR, Zheng X, Radich J, Baccarani M, Kantarjian HM, Levin WJ, Cortes JE, Jamieson C. PMID: 26688487.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCTClinical Trials
    36. Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1. Clin Lymphoma Myeloma Leuk. 2015 Jun; 15 Suppl:S167-9. Choi MY, Widhopf GF, Wu CC, Cui B, Lao F, Sadarangani A, Cavagnaro J, Prussak C, Carson DA, Jamieson C, Kipps TJ. PMID: 26297272.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    37. Genetic and epigenetic profiling of CLL disease progression reveals limited somatic evolution and suggests a relationship to memory-cell development. Blood Cancer J. 2015 Apr 10; 5:e303. Smith EN, Ghia EM, DeBoever CM, Rassenti LZ, Jepsen K, Yoon KA, Matsui H, Rozenzhak S, Alakus H, Shepard PJ, Dai Y, Khosroheidari M, Bina M, Gunderson KL, Messer K, Muthuswamy L, Hudson TJ, Harismendy O, Barrett CL, Jamieson CH, Carson DA, Kipps TJ, Frazer KA. PMID: 25860294.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    38. Historical views, conventional approaches, and evolving management strategies for myeloproliferative neoplasms. J Natl Compr Canc Netw. 2015 Apr; 13(4):424-34. Stein BL, Gotlib J, Arcasoy M, Nguyen MH, Shah N, Moliterno A, Jamieson C, Pollyea DA, Scott B, Wadleigh M, Levine R, Komrokji R, Klisovic R, Gundabolu K, Kropf P, Wetzler M, Oh ST, Ribeiro R, Paschal R, Mohan S, Podoltsev N, Prchal J, Talpaz M, Snyder D, Verstovsek S, Mesa RA. PMID: 25870379.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    39. GLI2 inhibition abrogates human leukemia stem cell dormancy. J Transl Med. 2015 Mar 21; 13:98. Sadarangani A, Pineda G, Lennon KM, Chun HJ, Shih A, Schairer AE, Court AC, Goff DJ, Prashad SL, Geron I, Wall R, McPherson JD, Moore RA, Pu M, Bao L, Jackson-Fisher A, Munchhof M, VanArsdale T, Reya T, Morris SR, Minden MD, Messer K, Mikkola HK, Marra MA, Hudson TJ, Jamieson CH. PMID: 25889765.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    40. Transcriptome sequencing reveals potential mechanism of cryptic 3' splice site selection in SF3B1-mutated cancers. PLoS Comput Biol. 2015 Mar; 11(3):e1004105. DeBoever C, Ghia EM, Shepard PJ, Rassenti L, Barrett CL, Jepsen K, Jamieson CH, Carson D, Kipps TJ, Frazer KA. PMID: 25768983.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    41. An RNA editing fingerprint of cancer stem cell reprogramming. J Transl Med. 2015 Feb 12; 13:52. Crews LA, Jiang Q, Zipeto MA, Lazzari E, Court AC, Ali S, Barrett CL, Frazer KA, Jamieson CH. PMID: 25889244.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    42. Novel insights into the biology and treatment of chronic myeloproliferative neoplasms. Leuk Lymphoma. 2015 Jul; 56(7):1938-48. Mughal TI, Barbui T, Abdel-Wahab O, Kralovics R, Jamieson C, Kvasnicka HM, Mullaly A, Rampal R, Mesa R, Kiladjian JJ, Deininger M, Prchal J, Hehlmann R, Saglio G, Van Etten RA. PMID: 25330439.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    43. Biased estimates of clonal evolution and subclonal heterogeneity can arise from PCR duplicates in deep sequencing experiments. Genome Biol. 2014 Aug 07; 15(8):420. Smith EN, Jepsen K, Khosroheidari M, Rassenti LZ, D'Antonio M, Ghia EM, Carson DA, Jamieson CH, Kipps TJ, Frazer KA. PMID: 25103687.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    44. The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia. J Exp Med. 2013 Jul 29; 210(8):1545-57. Mansour MR, Sanda T, Lawton LN, Li X, Kreslavsky T, Novina CD, Brand M, Gutierrez A, Kelliher MA, Jamieson CH, von Boehmer H, Young RA, Look AT. PMID: 23857984.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    45. Transcriptome sequencing of tumor subpopulations reveals a spectrum of therapeutic options for squamous cell lung cancer. PLoS One. 2013; 8(3):e58714. Barrett CL, Schwab RB, Jung H, Crain B, Goff DJ, Jamieson CH, Thistlethwaite PA, Harismendy O, Carson DA, Frazer KA. PMID: 23527012.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    46. TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia. Cancer Discov. 2013 May; 3(5):564-77. Sanda T, Tyner JW, Gutierrez A, Ngo VN, Glover J, Chang BH, Yost A, Ma W, Fleischman AG, Zhou W, Yang Y, Kleppe M, Ahn Y, Tatarek J, Kelliher MA, Neuberg DS, Levine RL, Moriggl R, Müller M, Gray NS, Jamieson CH, Weng AP, Staudt LM, Druker BJ, Look AT. PMID: 23471820.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    47. A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. Cell Stem Cell. 2013 Mar 07; 12(3):316-28. Goff DJ, Court Recart A, Sadarangani A, Chun HJ, Barrett CL, Krajewska M, Leu H, Low-Marchelli J, Ma W, Shih AY, Wei J, Zhai D, Geron I, Pu M, Bao L, Chuang R, Balaian L, Gotlib J, Minden M, Martinelli G, Rusert J, Dao KH, Shazand K, Wentworth P, Smith KM, Jamieson CA, Morris SR, Messer K, Goldstein LS, Hudson TJ, Marra M, Frazer KA, Pellecchia M, Reed JC, Jamieson CH. PMID: 23333150.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    48. ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. Proc Natl Acad Sci U S A. 2013 Jan 15; 110(3):1041-6. Jiang Q, Crews LA, Barrett CL, Chun HJ, Court AC, Isquith JM, Zipeto MA, Goff DJ, Minden M, Sadarangani A, Rusert JM, Dao KH, Morris SR, Goldstein LS, Marra MA, Frazer KA, Jamieson CH. PMID: 23275297.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    49. Advances in the biology and therapy of chronic myeloid leukemia: proceedings from the 6th Post-ASH International Chronic Myeloid Leukemia and Myeloproliferative Neoplasms Workshop. Leuk Lymphoma. 2013 Jun; 54(6):1151-8. Van Etten RA, Mauro M, Radich JP, Goldman JM, Saglio G, Jamieson C, Soverini S, Gambacorti-Passerini C, Hehlmann R, Martinelli G, Perrotti D, Scadden DT, Skorski T, Tefferi A, Mughal TI. PMID: 23121619.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    50. Optical imaging of progenitor cell homing to patient-derived tumors. Contrast Media Mol Imaging. 2012 Nov-Dec; 7(6):525-36. Newton IG, Plaisted WC, Messina-Graham S, Abrahamsson Schairer AE, Shih AY, Snyder EY, Jamieson CH, Mattrey RF. PMID: 22991319.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    51. Selective elimination of leukemia stem cells: hitting a moving target. Cancer Lett. 2013 Sep 10; 338(1):15-22. Crews LA, Jamieson CH. PMID: 22906415.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    52. Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. Cancer Cell. 2012 Aug 14; 22(2):209-21. Sanda T, Lawton LN, Barrasa MI, Fan ZP, Kohlhammer H, Gutierrez A, Ma W, Tatarek J, Ahn Y, Kelliher MA, Jamieson CH, Staudt LM, Young RA, Look AT. PMID: 22897851.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    53. NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. PLoS One. 2012; 7(6):e39725. Ma W, Gutierrez A, Goff DJ, Geron I, Sadarangani A, Jamieson CA, Court AC, Shih AY, Jiang Q, Wu CC, Li K, Smith KM, Crews LA, Gibson NW, Deichaite I, Morris SR, Wei P, Carson DA, Look AT, Jamieson CH. PMID: 22768113.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    54. Chronic myeloid leukemia stem cell biology. Curr Hematol Malig Rep. 2012 Jun; 7(2):125-32. Crews LA, Jamieson CH. PMID: 22467334.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    55. A novel patient-derived intra-femoral xenograft model of bone metastatic prostate cancer that recapitulates mixed osteolytic and osteoblastic lesions. J Transl Med. 2011 Oct 28; 9:185. Raheem O, Kulidjian AA, Wu C, Jeong YB, Yamaguchi T, Smith KM, Goff D, Leu H, Morris SR, Cacalano NA, Masuda K, Jamieson CH, Kane CJ, Jamieson CA. PMID: 22035283.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    56. Safety and efficacy of TG101348, a selective JAK2 inhibitor, in myelofibrosis. J Clin Oncol. 2011 Mar 01; 29(7):789-96. Pardanani A, Gotlib JR, Jamieson C, Cortes JE, Talpaz M, Stone RM, Silverman MH, Gilliland DG, Shorr J, Tefferi A. PMID: 21220608.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansCTClinical Trials
    57. Chronic myeloid leukemia: mechanisms of blastic transformation. J Clin Invest. 2010 Jul; 120(7):2254-64. Perrotti D, Jamieson C, Goldman J, Skorski T. PMID: 20592475.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansAnimals
    58. Molecular pathways to CML stem cells. Int J Hematol. 2010 Jun; 91(5):748-52. Rice KN, Jamieson CH. PMID: 20533007.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    59. Cancer stem cells and self-renewal. Clin Cancer Res. 2010 Jun 15; 16(12):3113-20. O'Brien CA, Kreso A, Jamieson CH. PMID: 20530701.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansAnimalsCells
    60. Split ends in CML: divergent roles of Hes1. Blood. 2010 Apr 08; 115(14):2726-7. Jamieson C. PMID: 20378758.
      View in: PubMed   Mentions: 1     Fields:    
    61. Cycling toward elimination of leukemic stem cells. Cell Stem Cell. 2010 Apr 02; 6(4):296-7. Goff D, Jamieson C. PMID: 20362532.
      View in: PubMed   Mentions: 3     Fields:    
    62. Inactivation of LEF1 in T-cell acute lymphoblastic leukemia. Blood. 2010 Apr 08; 115(14):2845-51. Gutierrez A, Sanda T, Ma W, Zhang J, Grebliunaite R, Dahlberg S, Neuberg D, Protopopov A, Winter SS, Larson RS, Borowitz MJ, Silverman LB, Chin L, Hunger SP, Jamieson C, Sallan SE, Look AT. PMID: 20124220.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    63. Dexamethasone induces dysferlin in myoblasts and enhances their myogenic differentiation. Neuromuscul Disord. 2010 Feb; 20(2):111-21. Belanto JJ, Diaz-Perez SV, Magyar CE, Maxwell MM, Yilmaz Y, Topp K, Boso G, Jamieson CH, Cacalano NA, Jamieson CA. PMID: 20080405.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    64. Chronic myeloproliferative diseases with and without the Ph chromosome: some unresolved issues. Leukemia. 2009 Oct; 23(10):1708-15. Goldman JM, Green AR, Holyoake T, Jamieson C, Mesa R, Mughal T, Pellicano F, Perrotti D, Skoda R, Vannucchi AM. PMID: 19641523.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    65. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell. 2009 Jul 23; 138(2):271-85. Jaiswal S, Jamieson CH, Pang WW, Park CY, Chao MP, Majeti R, Traver D, van Rooijen N, Weissman IL. PMID: 19632178.
      View in: PubMed   Mentions: 345     Fields:    Translation:HumansAnimalsCells
    66. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature. 2009 Apr 09; 458(7239):776-9. Zhao C, Chen A, Jamieson CH, Fereshteh M, Abrahamsson A, Blum J, Kwon HY, Kim J, Chute JP, Rizzieri D, Munchhof M, VanArsdale T, Beachy PA, Reya T. PMID: 19169242.
      View in: PubMed   Mentions: 297     Fields:    Translation:HumansAnimalsCells
    67. Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation. Proc Natl Acad Sci U S A. 2009 Mar 10; 106(10):3925-9. Abrahamsson AE, Geron I, Gotlib J, Dao KH, Barroga CF, Newton IG, Giles FJ, Durocher J, Creusot RS, Karimi M, Jones C, Zehnder JL, Keating A, Negrin RS, Weissman IL, Jamieson CH. PMID: 19237556.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    68. The MLLgnant consequences of reverting to an embryonic transcriptional program. Cell Stem Cell. 2009 Feb 06; 4(2):97-8. Jamieson C. PMID: 19200795.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    69. Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy. Int J Hematol. 2008 Dec; 88(5):471-475. Abe A, Minami Y, Hayakawa F, Kitamura K, Nomura Y, Murata M, Katsumi A, Kiyoi H, Jamieson CHM, Wang JYJ, Naoe T. PMID: 19039626.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    70. BCR-ABL-transformed GMP as myeloid leukemic stem cells. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17967-72. Minami Y, Stuart SA, Ikawa T, Jiang Y, Banno A, Hunton IC, Young DJ, Naoe T, Murre C, Jamieson CH, Wang JY. PMID: 19004799.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    71. BCR-ABL1-positive CML and BCR-ABL1-negative chronic myeloproliferative disorders: some common and contrasting features. Leukemia. 2008 Nov; 22(11):1975-89. Cross NC, Daley GQ, Green AR, Hughes TP, Jamieson C, Manley P, Mughal T, Perrotti D, Radich J, Skoda R, Soverini S, Vainchenker W, Verstovsek S, Villeval JL, Goldman JM. PMID: 19002192.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    72. Miscreant myeloproliferative disorder stem cells. Leukemia. 2008 Nov; 22(11):2011-9. Jamieson CH, Barroga CF, Vainchenker WP. PMID: 18923436.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    73. Chronic myeloid leukemia stem cells. J Clin Oncol. 2008 Jun 10; 26(17):2911-5. Kavalerchik E, Goff D, Jamieson CH. PMID: 18539972.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    74. Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors. Cancer Cell. 2008 Apr; 13(4):321-30. Geron I, Abrahamsson AE, Barroga CF, Kavalerchik E, Gotlib J, Hood JD, Durocher J, Mak CC, Noronha G, Soll RM, Tefferi A, Kaushansky K, Jamieson CH. PMID: 18394555.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    75. Stems cells and the pathways to aging and cancer. Cell. 2008 Feb 22; 132(4):681-96. Rossi DJ, Jamieson CH, Weissman IL. PMID: 18295583.
      View in: PubMed   Mentions: 307     Fields:    Translation:HumansAnimalsCells
    76. Chronic myeloid leukemia stem cells. Hematology Am Soc Hematol Educ Program. 2008; 436-42. Jamieson CH. PMID: 19074122.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    77. Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res. 2006 Oct 01; 66(19):9339-44. Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, Visvader J, Weissman IL, Wahl GM. PMID: 16990346.
      View in: PubMed   Mentions: 1003     Fields:    Translation:HumansAnimalsCells
    78. The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation. Proc Natl Acad Sci U S A. 2006 Apr 18; 103(16):6224-9. Jamieson CH, Gotlib J, Durocher JA, Chao MP, Mariappan MR, Lay M, Jones C, Zehnder JL, Lilleberg SL, Weissman IL. PMID: 16603627.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    79. Chronic versus acute myelogenous leukemia: a question of self-renewal. Cancer Cell. 2004 Dec; 6(6):531-3. Jamieson CH, Weissman IL, Passegué E. PMID: 15607956.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    80. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med. 2004 Aug 12; 351(7):657-67. Jamieson CH, Ailles LE, Dylla SJ, Muijtjens M, Jones C, Zehnder JL, Gotlib J, Li K, Manz MG, Keating A, Sawyers CL, Weissman IL. PMID: 15306667.
      View in: PubMed   Mentions: 467     Fields:    Translation:HumansCells
    81. Allogeneic hematopoietic cell transplantation for patients with high-risk acute lymphoblastic leukemia in first or second complete remission using fractionated total-body irradiation and high-dose etoposide: a 15-year experience. Exp Hematol. 2003 Oct; 31(10):981-6. Jamieson CH, Amylon MD, Wong RM, Blume KG. PMID: 14550815.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    82. Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? Proc Natl Acad Sci U S A. 2003 Sep 30; 100 Suppl 1:11842-9. Passegué E, Jamieson CH, Ailles LE, Weissman IL. PMID: 14504387.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansAnimalsCells
    83. Inhibition of the ubiquitin-proteasome system in Alzheimer's disease. Proc Natl Acad Sci U S A. 2000 Aug 29; 97(18):9902-6. Lam YA, Pickart CM, Alban A, Landon M, Jamieson C, Ramage R, Mayer RJ, Layfield R. PMID: 10944193.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    84. Human long-term bone marrow culture. Methods Mol Biol. 1997; 75:249-56. Clark BR, Jamieson C, Keating A. PMID: 9276274.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    85. In vitro clonal culture of human hematopoietic progenitor cells. Methods Mol Biol. 1997; 75:257-63. Clark BR, Jamieson C, Keating A. PMID: 9276275.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    86. Selective elimination of malignant stem cells using photosensitizers followed by light treatment. Stem Cells. 1995 Jul; 13(4):336-43. Levy JG, Dowding C, Mitchell D, Sorrenti R, Yip S, Jamieson C. PMID: 7549891.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    87. Efficacy of benzoporphyrin derivative, a photosensitizer, in selective destruction of leukemia cells using a murine tumor model. Exp Hematol. 1993 May; 21(5):629-34. Jamieson C, Richter A, Levy JG. PMID: 8513863.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    88. Inhibition of murine hematopoiesis by CAMAL, an inhibitor of human hematopoiesis. Leukemia. 1993 May; 7(5):717-24. Leitch HA, Yip ST, Jamieson CH, Levy JG. PMID: 8483324.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    89. Photodynamic elimination of clonogenic Ph+ chronic myeloid leukemia cells. Leuk Lymphoma. 1993; 11 Suppl 1:265-9. Keating A, Jamieson C, Hornby A, Wang XH, Levy J. PMID: 8251908.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    90. Relative sensitivity of leukemic (CML) and normal progenitor cells to treatment with the photosensitizer benzoporphyrin derivative and light. J Hematother. 1993; 2(3):383-6. Jamieson C, Hornby A, Richter A, Mitchell D, Levy J. PMID: 7922000.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    91. A T cell nuclear factor resembling NF-AT binds to an NF-kappa B site and to the conserved lymphokine promoter sequence "cytokine-1". J Biol Chem. 1992 Jan 25; 267(3):1864-71. McCaffrey PG, Jain J, Jamieson C, Sen R, Rao A. PMID: 1730723.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    92. Comparison of constitutive and inducible transcriptional enhancement mediated by kappa B-related sequences: modulation of activity in B cells by human T-cell leukemia virus type I tax gene. Proc Natl Acad Sci U S A. 1991 Mar 15; 88(6):2141-5. Mauxion F, Jamieson C, Yoshida M, Arai K, Sen R. PMID: 2006151.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    93. Identification of a functional NF-kappa B binding site in the murine T cell receptor beta 2 locus. J Exp Med. 1989 Nov 01; 170(5):1737-43. Jamieson C, Mauxion F, Sen R. PMID: 2530301.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
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