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Catriona Jamieson

Title(s)Professor, Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0695
La Jolla CA 92093
Phone858-534-7128
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    Collapse Biography 
    Collapse Awards and Honors
    UC San Diego Moores Cancer Center2020Rell Sunn Award
    CURE Media Group2017MPN Heroes Award
    UC San Diego2017Koman Family Presidential Endowed Chair in Cancer Research
    UC San Diego2016Chancellor’s Excellence in Stewardship Award

    Collapse Overview 
    Collapse Overview
    Research Interests
    Dr. Jamieson specialized in myeloproliferative disorders (MPDs) and leukemia. Myeloproliferative neoplasms are a family of uncommon but not rare degenerative disorders in which the body overproduces blood cells. Myeloproliferative neoplasms can cause many forms of blood clotting including heart attack, stroke, deep venous thrombosis, and pulmonary emboli and can develop into acute myelogenous leukemia. Although some effective treatments are available, they are laden with serious side effects. In addition, individuals can become resistant to the treatments. Dr. Jamieson studies the mutant stem cells and progenitor cells in myeloproliferative neoplasms. These cells can give rise to cancer stem cells. Cancer stem cells may lie low to evade chemotherapy and then activate again later, causing disease progression and resistance to treatment. Her goal is to find more selective, less toxic therapies. In the past two years, Dr. Jamieson’s stem-cell research studies have taken a great leap: from identifying a promising treatment in the laboratory to opening and completing the first clinical trial to target cancer stem cells in humans. This trial is the result of teamwork that has brought together her discoveries in myeloproliferative neoplasms and a local pharmaceutical company’s drug development track.

    Education and Training
    BS - Biology-Genetics, University of British Columbia - 1987
    Ph.D. - Microbiology, University of British Columbia - 1992
    MD - University of British Columbia - 1995
    Resident - University of British Columbia - 1995-1998
    Fellow, Bone Marrow Transplant - University of British Columbia - 1998
    Fellow, Bone Marrow Transplant - Stanford University - 1999-2002
    Postdoctoral Research Fellow - Stanford University - 2002-2005

    Collapse Research 
    Collapse Research Activities and Funding
    Development of An Orbital Laboratory to Advance Regenerative Medicine and Stem Cell Therapies
    NASA and Space Tango NASA Task #80JSC020F0200Jun 1, 2020 - May 31, 2023
    Role: UCSD Principal Investigator
    Detection and Targeting of Enzymatic Base Editing Deregulation in Leukemia Stem Cells
    The Leukemia & Lymphoma Society BCDG 8020-20Apr 1, 2020 - Mar 31, 2023
    Role: Principal Investigator
    Detection and Inhibition of Malignant RNA Processing Deregulation in Myelofibrosis
    The Leukemia & Lymphoma Society MPN Research FoundationNov 1, 2019 - Oct 31, 2021
    Role: Principal Investigator
    Defining the Niche-dependent Role of RNA Editing in Aged and MDS Hematopoietic Stem and Progenitor Cell Dysfunction
    NIH R01DK114468Aug 20, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Characterization of the Role of ADAR1 in Oncogenic Transformation of Progenitors
    NIH R01CA205944Dec 8, 2016 - Nov 30, 2021
    Role: Principal Investigator
    (PQC2) Niche-responsive RNA editing by ADAR1 in dormant multiple myeloma initiating cell maintenance
    NIH R21CA194679May 1, 2015 - Apr 30, 2017
    Role: Principal Investigator
    Identifying microRNA Targets for Early Detection of Myeloproliferative Neoplasms
    NIH R21CA189705Apr 1, 2015 - Mar 31, 2017
    Role: Principal Investigator
    2009 Stem Cells and Cancer Gordon Conference
    NIH R13CA139606Sep 1, 2009 - Aug 31, 2010
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH P30CA023100Apr 1, 1978 - Nov 30, 1991
    Role: Deputy Director and Co-leader of Hematologic Malignancies Program

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution. Cell Rep. 2021 Jan 26; 34(4):108670. Jiang Q, Isquith J, Ladel L, Mark A, Holm F, Mason C, He Y, Mondala P, Oliver I, Pham J, Ma W, Reynoso E, Ali S, Morris IJ, Diep R, Nasamran C, Xu G, Sasik R, Rosenthal SB, Birmingham A, Coso S, Pineda G, Crews L, Donohoe ME, Venter JC, Whisenant T, Mesa RA, Alexandrov LB, Fisch KM, Jamieson C. PMID: 33503434.
      View in: PubMed   Mentions:    Fields:    
    2. Selective antisense oligonucleotide inhibition of human IRF4 prevents malignant myeloma regeneration via cell cycle disruption. Cell Stem Cell. 2021 Jan 20. Mondala PK, Vora AA, Zhou T, Lazzari E, Ladel L, Luo X, Kim Y, Costello C, MacLeod AR, Jamieson CHM, Crews LA. PMID: 33476575.
      View in: PubMed   Mentions:    Fields:    
    3. Evaluation of the Relationship of Glasdegib Exposure and Safety End Points in Patients With Refractory Solid Tumors and Hematologic Malignancies. J Clin Pharmacol. 2021 Mar; 61(3):349-359. Ruiz-Garcia A, Shaik N, Lin S, Jamieson C, Heuser M, Chan G. PMID: 32974950.
      View in: PubMed   Mentions:    Fields:    
    4. Myeloid/Lymphoid Neoplasms with Eosinophilia and TK Fusion Genes, Version 3.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2020 09; 18(9):1248-1269. Gerds AT, Gotlib J, Bose P, Deininger MW, Dunbar A, Elshoury A, George TI, Gojo I, Gundabolu K, Hexner E, Hobbs G, Jain T, Jamieson C, Kuykendall AT, McMahon B, Mohan SR, Oehler V, Oh S, Pardanani A, Podoltsev N, Ranheim E, Rein L, Salit R, Snyder DS, Stein BL, Talpaz M, Thota S, Vachhani P, Wadleigh M, Walsh K, Ward DC, Bergman MA, Sundar H. PMID: 32886902.
      View in: PubMed   Mentions:    Fields:    
    5. Persistence of Drug-Resistant Leukemic Stem Cells and Impaired NK Cell Immunity in CML Patients Depend on MIR300 Antiproliferative and PP2A-Activating Functions. Blood Cancer Discov. 2020 Jul; 1(1):48-67. Silvestri G, Trotta R, Stramucci L, Ellis JJ, Harb JG, Neviani P, Wang S, Eisfeld AK, Walker CJ, Zhang B, Srutova K, Gambacorti-Passerini C, Pineda G, Jamieson CHM, Stagno F, Vigneri P, Nteliopoulos G, May PC, Reid AG, Garzon R, Roy DC, Moutuou MM, Guimond M, Hokland P, Deininger MW, Fitzgerald G, Harman C, Dazzi F, Milojkovic D, Apperley JF, Marcucci G, Qi J, Polakova KM, Zou Y, Fan X, Baer MR, Calabretta B, Perrotti D. PMID: 32974613.
      View in: PubMed   Mentions:
    6. Post-Transcriptional Regulation of Homeostatic, Stressed, and Malignant Stem Cells. Cell Stem Cell. 2020 02 06; 26(2):138-159. Chua BA, Van Der Werf I, Jamieson C, Signer RAJ. PMID: 32032524.
      View in: PubMed   Mentions: 3     Fields:    
    7. Hippo kinase loss contributes to del(20q) hematologic malignancies through chronic innate immune activation. Blood. 2019 11 14; 134(20):1730-1744. Stoner SA, Yan M, Liu KTH, Arimoto KI, Shima T, Wang HY, Johnson DT, Bejar R, Jamieson C, Guan KL, Zhang DE. PMID: 31434702.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    8. A-to-I RNA editing in leukemia stem cells - set ADAR1 on the radar. Oncotarget. 2019 Oct 22; 10(58):6047-6048. Jiang Q, Diep R, Jamieson C. PMID: 31692993.
      View in: PubMed   Mentions:    Fields:    
    9. To PARP or not to PARP?-Toward sensitizing acute myeloid leukemia stem cells to immunotherapy. EMBO J. 2019 10 04; 38(21):e103479. Heyman B, Jamieson C. PMID: 31633196.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    10. Cirmtuzumab blocks Wnt5a/ROR1 stimulation of NF-κB to repress autocrine STAT3 activation in chronic lymphocytic leukemia. Blood. 2019 09 26; 134(13):1084-1094. Chen Y, Chen L, Yu J, Ghia EM, Choi MY, Zhang L, Zhang S, Sanchez-Lopez E, Widhopf GF, Messer K, Rassenti LZ, Jamieson C, Kipps TJ. PMID: 31409670.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    11. Corrigendum to "Phase 1/2 trial of glasdegib in patients with primary or secondary myelofibrosis previously treated with ruxolitinib" [Leukemia Res. 79 (2019) 38-44]. Leuk Res. 2019 Jun; 81:105. Gerds AT, Tauchi T, Ritchie E, Deininger M, Jamieson C, Mesa R, Heaney M, Komatsu N, Minami H, Su Y, Shaik N, Zhang X, DiRienzo C, Zeremski M, Chan G, Talpaz M. PMID: 31029462.
      View in: PubMed   Mentions:    Fields:    
    12. The Yin and Yang of RNA Methylation: An Imbalance of Erasers Enhances Sensitivity to FTO Demethylase Small-Molecule Targeting in Leukemia Stem Cells. Cancer Cell. 2019 04 15; 35(4):540-541. Van Der Werf I, Jamieson C. PMID: 30991023.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    13. Phase 1/2 trial of glasdegib in patients with primary or secondary myelofibrosis previously treated with ruxolitinib. Leuk Res. 2019 04; 79:38-44. Gerds AT, Tauchi T, Ritchie E, Deininger M, Jamieson C, Mesa R, Heaney M, Komatsu N, Minami H, Su Y, Shaik N, Zhang X, DiRienzo C, Zeremski M, Chan G, Talpaz M. PMID: 30849661.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    14. Hyper-Editing of Cell-Cycle Regulatory and Tumor Suppressor RNA Promotes Malignant Progenitor Propagation. Cancer Cell. 2019 01 14; 35(1):81-94.e7. Jiang Q, Isquith J, Zipeto MA, Diep RH, Pham J, Delos Santos N, Reynoso E, Chau J, Leu H, Lazzari E, Melese E, Ma W, Fang R, Minden M, Morris S, Ren B, Pineda G, Holm F, Jamieson C. PMID: 30612940.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    15. Comprehensive Genomic Profiling Reveals Diverse but Actionable Molecular Portfolios across Hematologic Malignancies: Implications for Next Generation Clinical Trials. Cancers (Basel). 2018 Dec 21; 11(1). Galanina N, Bejar R, Choi M, Goodman A, Wieduwilt M, Mulroney C, Kim L, Yeerna H, Tamayo P, Vergilio JA, Mughal TI, Miller V, Jamieson C, Kurzrock R. PMID: 30583461.
      View in: PubMed   Mentions:
    16. Systemic Mastocytosis, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2018 12; 16(12):1500-1537. Gotlib J, Gerds AT, Bose P, Castells MC, Deininger MW, Gojo I, Gundabolu K, Hobbs G, Jamieson C, McMahon B, Mohan SR, Oehler V, Oh S, Padron E, Pancari P, Papadantonakis N, Pardanani A, Podoltsev N, Rampal R, Ranheim E, Rein L, Snyder DS, Stein BL, Talpaz M, Thota S, Wadleigh M, Walsh K, Bergman MA, Sundar H. PMID: 30545997.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    17. A First-in-Human, Phase I Study of Neural Stem Cell Transplantation for Chronic Spinal Cord Injury. Cell Stem Cell. 2018 Jun 01; 22(6):941-950.e6. Curtis E, Martin JR, Gabel B, Sidhu N, Rzesiewicz TK, Mandeville R, Van Gorp S, Leerink M, Tadokoro T, Marsala S, Jamieson C, Marsala M, Ciacci JD. PMID: 29859175.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    18. Phase I Trial: Cirmtuzumab Inhibits ROR1 Signaling and Stemness Signatures in Patients with Chronic Lymphocytic Leukemia. Cell Stem Cell. 2018 Jun 01; 22(6):951-959.e3. Choi MY, Widhopf GF, Ghia EM, Kidwell RL, Hasan MK, Yu J, Rassenti LZ, Chen L, Chen Y, Pittman E, Pu M, Messer K, Prussak CE, Castro JE, Jamieson C, Kipps TJ. PMID: 29859176.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCellsCTClinical Trials
    19. CIRM Alpha Stem Cell Clinics: Collaboratively Addressing Regenerative Medicine Challenges. Cell Stem Cell. 2018 06 01; 22(6):801-805. Jamieson CHM, Millan MT, Creasey AA, Lomax G, Donohoe ME, Walters MC, Abedi M, Bota DA, Zaia JA, Adams JS. PMID: 29859170.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    20. The Challenges of First-in-Human Stem Cell Clinical Trials: What Does This Mean for Ethics and Institutional Review Boards? Stem Cell Reports. 2018 May 08; 10(5):1429-1431. Barker RA, Carpenter MK, Forbes S, Goldman SA, Jamieson C, Murry CE, Takahashi J, Weir G. PMID: 29742388.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    21. Pacritinib vs Best Available Therapy, Including Ruxolitinib, in Patients With Myelofibrosis: A Randomized Clinical Trial. JAMA Oncol. 2018 05 01; 4(5):652-659. Mascarenhas J, Hoffman R, Talpaz M, Gerds AT, Stein B, Gupta V, Szoke A, Drummond M, Pristupa A, Granston T, Daly R, Al-Fayoumi S, Callahan JA, Singer JW, Gotlib J, Jamieson C, Harrison C, Mesa R, Verstovsek S. PMID: 29522138.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    22. BET'ing on Dual JAK/BET Inhibition as a Therapeutic Strategy for Myeloproliferative Neoplasms. Cancer Cell. 2018 01 08; 33(1):3-5. Jiang Q, Jamieson C. PMID: 29316431.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    23. Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma. Nat Commun. 2017 12 04; 8(1):1922. Lazzari E, Mondala PK, Santos ND, Miller AC, Pineda G, Jiang Q, Leu H, Ali SA, Ganesan AP, Wu CN, Costello C, Minden M, Chiaramonte R, Stewart AK, Crews LA, Jamieson CHM. PMID: 29203771.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    24. NCCN Guidelines Insights: Myeloproliferative Neoplasms, Version 2.2018. J Natl Compr Canc Netw. 2017 10; 15(10):1193-1207. Mesa RA, Jamieson C, Bhatia R, Deininger MW, Fletcher CD, Gerds AT, Gojo I, Gotlib J, Gundabolu K, Hobbs G, McMahon B, Mohan SR, Oh S, Padron E, Papadantonakis N, Pancari P, Podoltsev N, Rampal R, Ranheim E, Reddy V, Rein LAM, Scott B, Snyder DS, Stein BL, Talpaz M, Verstovsek S, Wadleigh M, Wang ES, Bergman MA, Gregory KM, Sundar H. PMID: 28982745.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    25. Cancer: Bad blood promotes tumour progression. Nature. 2017 09 27; 549(7673):465-466. Jamieson C. PMID: 28959960.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    26. RNA editing-dependent epitranscriptome diversity in cancer stem cells. Nat Rev Cancer. 2017 06; 17(6):381-392. Jiang Q, Crews LA, Holm F, Jamieson CHM. PMID: 28416802.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    27. Myeloproliferative Neoplasms, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2016 12; 14(12):1572-1611. Mesa R, Jamieson C, Bhatia R, Deininger MW, Gerds AT, Gojo I, Gotlib J, Gundabolu K, Hobbs G, Klisovic RB, Kropf P, Mohan SR, Oh S, Padron E, Podoltsev N, Pollyea DA, Rampal R, Rein LA, Scott B, Snyder DS, Stein BL, Verstovsek S, Wadleigh M, Wang ES, Bergman MA, Gregory KM, Sundar H. PMID: 27956542.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    28. Thoracic Extramedullary Hematopoiesis Mimicking Metastatic Cancer. J Bronchology Interv Pulmonol. 2016 Oct; 23(4):343-346. Ha D, Liao X, Wang HY, Jamieson C, Magaña M, Makani S. PMID: 27479013.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    29. Specific bone region localization of osteolytic versus osteoblastic lesions in a patient-derived xenograft model of bone metastatic prostate cancer. Asian J Urol. 2016 Oct; 3(4):229-239. Hirata T, Park SC, Muldong MT, Wu CN, Yamaguchi T, Strasner A, Raheem O, Kumon H, Sah RL, Cacalano NA, Jamieson CHM, Kane CJ, Masuda K, Kulidjian AA, Jamieson CAM. PMID: 29264191.
      View in: PubMed   Mentions:
    30. Multiple myeloma-derived Jagged ligands increases autocrine and paracrine interleukin-6 expression in bone marrow niche. Oncotarget. 2016 Aug 30; 7(35):56013-56029. Colombo M, Galletti S, Bulfamante G, Falleni M, Tosi D, Todoerti K, Lazzari E, Crews LA, Jamieson CH, Ravaioli S, Baccianti F, Garavelli S, Platonova N, Neri A, Chiaramonte R. PMID: 27463014.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    31. RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML. Cell Stem Cell. 2016 11 03; 19(5):599-612. Crews LA, Balaian L, Delos Santos NP, Leu HS, Court AC, Lazzari E, Sadarangani A, Zipeto MA, La Clair JJ, Villa R, Kulidjian A, Storb R, Morris SR, Ball ED, Burkart MD, Jamieson CHM. PMID: 27570067.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    32. A phase I, open-label, dose-escalation, multicenter study of the JAK2 inhibitor NS-018 in patients with myelofibrosis. Leukemia. 2017 02; 31(2):393-402. Verstovsek S, Talpaz M, Ritchie E, Wadleigh M, Odenike O, Jamieson C, Stein B, Uno T, Mesa RA. PMID: 27479177.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    33. ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis. Cell Stem Cell. 2016 08 04; 19(2):177-191. Zipeto MA, Court AC, Sadarangani A, Delos Santos NP, Balaian L, Chun HJ, Pineda G, Morris SR, Mason CN, Geron I, Barrett C, Goff DJ, Wall R, Pellecchia M, Minden M, Frazer KA, Marra MA, Crews LA, Jiang Q, Jamieson CHM. PMID: 27292188.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    34. Tracking of Normal and Malignant Progenitor Cell Cycle Transit in a Defined Niche. Sci Rep. 2016 Apr 04; 6:23885. Pineda G, Lennon KM, Delos Santos NP, Lambert-Fliszar F, Riso GL, Lazzari E, Marra MA, Morris S, Sakaue-Sawano A, Miyawaki A, Jamieson CH. PMID: 27041210.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    35. Reversion to an embryonic alternative splicing program enhances leukemia stem cell self-renewal. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15444-9. Holm F, Hellqvist E, Mason CN, Ali SA, Delos-Santos N, Barrett CL, Chun HJ, Minden MD, Moore RA, Marra MA, Runza V, Frazer KA, Sadarangani A, Jamieson CH. PMID: 26621726.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    36. Effect of treatment with a JAK2-selective inhibitor, fedratinib, on bone marrow fibrosis in patients with myelofibrosis. J Transl Med. 2015 Sep 10; 13:294. Jamieson C, Hasserjian R, Gotlib J, Cortes J, Stone R, Talpaz M, Thiele J, Rodig S, Pozdnyakova O. PMID: 26357842.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCellsCTClinical Trials
    37. RNA rewriting, recoding, and rewiring in human disease. Trends Mol Med. 2015 Sep; 21(9):549-59. Zipeto MA, Jiang Q, Melese E, Jamieson CH. PMID: 26259769.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    38. A phase 2 randomized dose-ranging study of the JAK2-selective inhibitor fedratinib (SAR302503) in patients with myelofibrosis. Blood Cancer J. 2015 Aug 07; 5:e335. Pardanani A, Tefferi A, Jamieson C, Gabrail NY, Lebedinsky C, Gao G, Liu F, Xu C, Cao H, Talpaz M. PMID: 26252788.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCTClinical Trials
    39. Treatment with PF-04449913, an oral smoothened antagonist, in patients with myeloid malignancies: a phase 1 safety and pharmacokinetics study. Lancet Haematol. 2015 Aug; 2(8):e339-46. Martinelli G, Oehler VG, Papayannidis C, Courtney R, Shaik MN, Zhang X, O'Connell A, McLachlan KR, Zheng X, Radich J, Baccarani M, Kantarjian HM, Levin WJ, Cortes JE, Jamieson C. PMID: 26688487.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCTClinical Trials
    40. Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1. Clin Lymphoma Myeloma Leuk. 2015 Jun; 15 Suppl:S167-9. Choi MY, Widhopf GF, Wu CC, Cui B, Lao F, Sadarangani A, Cavagnaro J, Prussak C, Carson DA, Jamieson C, Kipps TJ. PMID: 26297272.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    41. Genetic and epigenetic profiling of CLL disease progression reveals limited somatic evolution and suggests a relationship to memory-cell development. Blood Cancer J. 2015 Apr 10; 5:e303. Smith EN, Ghia EM, DeBoever CM, Rassenti LZ, Jepsen K, Yoon KA, Matsui H, Rozenzhak S, Alakus H, Shepard PJ, Dai Y, Khosroheidari M, Bina M, Gunderson KL, Messer K, Muthuswamy L, Hudson TJ, Harismendy O, Barrett CL, Jamieson CH, Carson DA, Kipps TJ, Frazer KA. PMID: 25860294.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    42. Historical views, conventional approaches, and evolving management strategies for myeloproliferative neoplasms. J Natl Compr Canc Netw. 2015 Apr; 13(4):424-34. Stein BL, Gotlib J, Arcasoy M, Nguyen MH, Shah N, Moliterno A, Jamieson C, Pollyea DA, Scott B, Wadleigh M, Levine R, Komrokji R, Klisovic R, Gundabolu K, Kropf P, Wetzler M, Oh ST, Ribeiro R, Paschal R, Mohan S, Podoltsev N, Prchal J, Talpaz M, Snyder D, Verstovsek S, Mesa RA. PMID: 25870379.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    43. GLI2 inhibition abrogates human leukemia stem cell dormancy. J Transl Med. 2015 Mar 21; 13:98. Sadarangani A, Pineda G, Lennon KM, Chun HJ, Shih A, Schairer AE, Court AC, Goff DJ, Prashad SL, Geron I, Wall R, McPherson JD, Moore RA, Pu M, Bao L, Jackson-Fisher A, Munchhof M, VanArsdale T, Reya T, Morris SR, Minden MD, Messer K, Mikkola HK, Marra MA, Hudson TJ, Jamieson CH. PMID: 25889765.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    44. Transcriptome sequencing reveals potential mechanism of cryptic 3' splice site selection in SF3B1-mutated cancers. PLoS Comput Biol. 2015 Mar; 11(3):e1004105. DeBoever C, Ghia EM, Shepard PJ, Rassenti L, Barrett CL, Jepsen K, Jamieson CH, Carson D, Kipps TJ, Frazer KA. PMID: 25768983.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    45. An RNA editing fingerprint of cancer stem cell reprogramming. J Transl Med. 2015 Feb 12; 13:52. Crews LA, Jiang Q, Zipeto MA, Lazzari E, Court AC, Ali S, Barrett CL, Frazer KA, Jamieson CH. PMID: 25889244.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    46. Novel insights into the biology and treatment of chronic myeloproliferative neoplasms. Leuk Lymphoma. 2015 Jul; 56(7):1938-48. PMID: 25330439.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    47. Biased estimates of clonal evolution and subclonal heterogeneity can arise from PCR duplicates in deep sequencing experiments. Genome Biol. 2014 Aug 07; 15(8):420. PMID: 25103687.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    48. The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia. J Exp Med. 2013 Jul 29; 210(8):1545-57. PMID: 23857984.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    49. Transcriptome sequencing of tumor subpopulations reveals a spectrum of therapeutic options for squamous cell lung cancer. PLoS One. 2013; 8(3):e58714. PMID: 23527012.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    50. TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia. Cancer Discov. 2013 May; 3(5):564-77. PMID: 23471820.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    51. A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. Cell Stem Cell. 2013 Mar 07; 12(3):316-28. PMID: 23333150.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    52. ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. Proc Natl Acad Sci U S A. 2013 Jan 15; 110(3):1041-6. PMID: 23275297.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    53. Advances in the biology and therapy of chronic myeloid leukemia: proceedings from the 6th Post-ASH International Chronic Myeloid Leukemia and Myeloproliferative Neoplasms Workshop. Leuk Lymphoma. 2013 Jun; 54(6):1151-8. PMID: 23121619.
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    54. Optical imaging of progenitor cell homing to patient-derived tumors. Contrast Media Mol Imaging. 2012 Nov-Dec; 7(6):525-36. PMID: 22991319.
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    55. Selective elimination of leukemia stem cells: hitting a moving target. Cancer Lett. 2013 Sep 10; 338(1):15-22. PMID: 22906415.
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    56. Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. Cancer Cell. 2012 Aug 14; 22(2):209-21. PMID: 22897851.
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    57. NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. PLoS One. 2012; 7(6):e39725. PMID: 22768113.
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    58. Chronic myeloid leukemia stem cell biology. Curr Hematol Malig Rep. 2012 Jun; 7(2):125-32. PMID: 22467334.
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    59. A novel patient-derived intra-femoral xenograft model of bone metastatic prostate cancer that recapitulates mixed osteolytic and osteoblastic lesions. J Transl Med. 2011 Oct 28; 9:185. PMID: 22035283.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    60. Safety and efficacy of TG101348, a selective JAK2 inhibitor, in myelofibrosis. J Clin Oncol. 2011 Mar 01; 29(7):789-96. Pardanani A, Gotlib JR, Jamieson C, Cortes JE, Talpaz M, Stone RM, Silverman MH, Gilliland DG, Shorr J, Tefferi A. PMID: 21220608.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansCTClinical Trials
    61. Chronic myeloid leukemia: mechanisms of blastic transformation. J Clin Invest. 2010 Jul; 120(7):2254-64. Perrotti D, Jamieson C, Goldman J, Skorski T. PMID: 20592475.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansAnimals
    62. Molecular pathways to CML stem cells. Int J Hematol. 2010 Jun; 91(5):748-52. Rice KN, Jamieson CH. PMID: 20533007.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    63. Cancer stem cells and self-renewal. Clin Cancer Res. 2010 Jun 15; 16(12):3113-20. O'Brien CA, Kreso A, Jamieson CH. PMID: 20530701.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansAnimalsCells
    64. Split ends in CML: divergent roles of Hes1. Blood. 2010 Apr 08; 115(14):2726-7. Jamieson C. PMID: 20378758.
      View in: PubMed   Mentions: 1     Fields:    
    65. Cycling toward elimination of leukemic stem cells. Cell Stem Cell. 2010 Apr 02; 6(4):296-7. Goff D, Jamieson C. PMID: 20362532.
      View in: PubMed   Mentions: 3     Fields:    
    66. Inactivation of LEF1 in T-cell acute lymphoblastic leukemia. Blood. 2010 Apr 08; 115(14):2845-51. Gutierrez A, Sanda T, Ma W, Zhang J, Grebliunaite R, Dahlberg S, Neuberg D, Protopopov A, Winter SS, Larson RS, Borowitz MJ, Silverman LB, Chin L, Hunger SP, Jamieson C, Sallan SE, Look AT. PMID: 20124220.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    67. Dexamethasone induces dysferlin in myoblasts and enhances their myogenic differentiation. Neuromuscul Disord. 2010 Feb; 20(2):111-21. Belanto JJ, Diaz-Perez SV, Magyar CE, Maxwell MM, Yilmaz Y, Topp K, Boso G, Jamieson CH, Cacalano NA, Jamieson CA. PMID: 20080405.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    68. Chronic myeloproliferative diseases with and without the Ph chromosome: some unresolved issues. Leukemia. 2009 Oct; 23(10):1708-15. Goldman JM, Green AR, Holyoake T, Jamieson C, Mesa R, Mughal T, Pellicano F, Perrotti D, Skoda R, Vannucchi AM. PMID: 19641523.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    69. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell. 2009 Jul 23; 138(2):271-85. Jaiswal S, Jamieson CH, Pang WW, Park CY, Chao MP, Majeti R, Traver D, van Rooijen N, Weissman IL. PMID: 19632178.
      View in: PubMed   Mentions: 382     Fields:    Translation:HumansAnimalsCells
    70. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature. 2009 Apr 09; 458(7239):776-9. Zhao C, Chen A, Jamieson CH, Fereshteh M, Abrahamsson A, Blum J, Kwon HY, Kim J, Chute JP, Rizzieri D, Munchhof M, VanArsdale T, Beachy PA, Reya T. PMID: 19169242.
      View in: PubMed   Mentions: 320     Fields:    Translation:HumansAnimalsCells
    71. Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation. Proc Natl Acad Sci U S A. 2009 Mar 10; 106(10):3925-9. Abrahamsson AE, Geron I, Gotlib J, Dao KH, Barroga CF, Newton IG, Giles FJ, Durocher J, Creusot RS, Karimi M, Jones C, Zehnder JL, Keating A, Negrin RS, Weissman IL, Jamieson CH. PMID: 19237556.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    72. The MLLgnant consequences of reverting to an embryonic transcriptional program. Cell Stem Cell. 2009 Feb 06; 4(2):97-8. Jamieson C. PMID: 19200795.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    73. Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy. Int J Hematol. 2008 Dec; 88(5):471-475. Abe A, Minami Y, Hayakawa F, Kitamura K, Nomura Y, Murata M, Katsumi A, Kiyoi H, Jamieson CHM, Wang JYJ, Naoe T. PMID: 19039626.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    74. BCR-ABL-transformed GMP as myeloid leukemic stem cells. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17967-72. Minami Y, Stuart SA, Ikawa T, Jiang Y, Banno A, Hunton IC, Young DJ, Naoe T, Murre C, Jamieson CH, Wang JY. PMID: 19004799.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    75. BCR-ABL1-positive CML and BCR-ABL1-negative chronic myeloproliferative disorders: some common and contrasting features. Leukemia. 2008 Nov; 22(11):1975-89. Cross NC, Daley GQ, Green AR, Hughes TP, Jamieson C, Manley P, Mughal T, Perrotti D, Radich J, Skoda R, Soverini S, Vainchenker W, Verstovsek S, Villeval JL, Goldman JM. PMID: 19002192.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    76. Miscreant myeloproliferative disorder stem cells. Leukemia. 2008 Nov; 22(11):2011-9. Jamieson CH, Barroga CF, Vainchenker WP. PMID: 18923436.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    77. Chronic myeloid leukemia stem cells. J Clin Oncol. 2008 Jun 10; 26(17):2911-5. Kavalerchik E, Goff D, Jamieson CH. PMID: 18539972.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    78. Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors. Cancer Cell. 2008 Apr; 13(4):321-30. Geron I, Abrahamsson AE, Barroga CF, Kavalerchik E, Gotlib J, Hood JD, Durocher J, Mak CC, Noronha G, Soll RM, Tefferi A, Kaushansky K, Jamieson CH. PMID: 18394555.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    79. Stems cells and the pathways to aging and cancer. Cell. 2008 Feb 22; 132(4):681-96. Rossi DJ, Jamieson CH, Weissman IL. PMID: 18295583.
      View in: PubMed   Mentions: 320     Fields:    Translation:HumansAnimalsCells
    80. Chronic myeloid leukemia stem cells. Hematology Am Soc Hematol Educ Program. 2008; 436-42. Jamieson CH. PMID: 19074122.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    81. Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res. 2006 Oct 01; 66(19):9339-44. Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, Visvader J, Weissman IL, Wahl GM. PMID: 16990346.
      View in: PubMed   Mentions: 1061     Fields:    Translation:HumansAnimalsCells
    82. The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation. Proc Natl Acad Sci U S A. 2006 Apr 18; 103(16):6224-9. Jamieson CH, Gotlib J, Durocher JA, Chao MP, Mariappan MR, Lay M, Jones C, Zehnder JL, Lilleberg SL, Weissman IL. PMID: 16603627.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    83. Chronic versus acute myelogenous leukemia: a question of self-renewal. Cancer Cell. 2004 Dec; 6(6):531-3. Jamieson CH, Weissman IL, Passegué E. PMID: 15607956.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    84. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med. 2004 Aug 12; 351(7):657-67. Jamieson CH, Ailles LE, Dylla SJ, Muijtjens M, Jones C, Zehnder JL, Gotlib J, Li K, Manz MG, Keating A, Sawyers CL, Weissman IL. PMID: 15306667.
      View in: PubMed   Mentions: 484     Fields:    Translation:HumansCells
    85. Allogeneic hematopoietic cell transplantation for patients with high-risk acute lymphoblastic leukemia in first or second complete remission using fractionated total-body irradiation and high-dose etoposide: a 15-year experience. Exp Hematol. 2003 Oct; 31(10):981-6. Jamieson CH, Amylon MD, Wong RM, Blume KG. PMID: 14550815.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    86. Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? Proc Natl Acad Sci U S A. 2003 Sep 30; 100 Suppl 1:11842-9. Passegué E, Jamieson CH, Ailles LE, Weissman IL. PMID: 14504387.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansAnimalsCells
    87. Inhibition of the ubiquitin-proteasome system in Alzheimer's disease. Proc Natl Acad Sci U S A. 2000 Aug 29; 97(18):9902-6. Lam YA, Pickart CM, Alban A, Landon M, Jamieson C, Ramage R, Mayer RJ, Layfield R. PMID: 10944193.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    88. In vitro clonal culture of human hematopoietic progenitor cells. Methods Mol Biol. 1997; 75:257-63. Clark BR, Jamieson C, Keating A. PMID: 9276275.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    89. Human long-term bone marrow culture. Methods Mol Biol. 1997; 75:249-56. Clark BR, Jamieson C, Keating A. PMID: 9276274.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    90. Selective elimination of malignant stem cells using photosensitizers followed by light treatment. Stem Cells. 1995 Jul; 13(4):336-43. Levy JG, Dowding C, Mitchell D, Sorrenti R, Yip S, Jamieson C. PMID: 7549891.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    91. Efficacy of benzoporphyrin derivative, a photosensitizer, in selective destruction of leukemia cells using a murine tumor model. Exp Hematol. 1993 May; 21(5):629-34. Jamieson C, Richter A, Levy JG. PMID: 8513863.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    92. Inhibition of murine hematopoiesis by CAMAL, an inhibitor of human hematopoiesis. Leukemia. 1993 May; 7(5):717-24. Leitch HA, Yip ST, Jamieson CH, Levy JG. PMID: 8483324.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    93. Relative sensitivity of leukemic (CML) and normal progenitor cells to treatment with the photosensitizer benzoporphyrin derivative and light. J Hematother. 1993; 2(3):383-6. Jamieson C, Hornby A, Richter A, Mitchell D, Levy J. PMID: 7922000.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    94. Photodynamic elimination of clonogenic Ph+ chronic myeloid leukemia cells. Leuk Lymphoma. 1993; 11 Suppl 1:265-9. Keating A, Jamieson C, Hornby A, Wang XH, Levy J. PMID: 8251908.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    95. A T cell nuclear factor resembling NF-AT binds to an NF-kappa B site and to the conserved lymphokine promoter sequence "cytokine-1". J Biol Chem. 1992 Jan 25; 267(3):1864-71. McCaffrey PG, Jain J, Jamieson C, Sen R, Rao A. PMID: 1730723.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    96. Comparison of constitutive and inducible transcriptional enhancement mediated by kappa B-related sequences: modulation of activity in B cells by human T-cell leukemia virus type I tax gene. Proc Natl Acad Sci U S A. 1991 Mar 15; 88(6):2141-5. Mauxion F, Jamieson C, Yoshida M, Arai K, Sen R. PMID: 2006151.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    97. Identification of a functional NF-kappa B binding site in the murine T cell receptor beta 2 locus. J Exp Med. 1989 Nov 01; 170(5):1737-43. Jamieson C, Mauxion F, Sen R. PMID: 2530301.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
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