Elizabeth Winzeler

Title(s)Professor, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-4049-2113 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Lewis and Clark College, Portland, ORBA1984Art/Natural Sciences
    Oregon State University, Corvallis, ORMS1990Biochemistry
    Stanford University School of Medicine, Stanford, CAPh.D.1996Developmental Biology
    Stanford University School of Medicine, Stanford, CAPostdoctoral1999Biochemistry
    Collapse Awards and Honors
    National Academy of Medicine2021Member
    ASTMH2018Trager Award
    ASBMB2018CC Wang Award
    Medicines for Malaria Venture2017Project of the year
    American Society of Tropical Medicine and Hygiene2015Bailey Ashford Medal
    American Society for Microbiology2016Fellow
    WM Keck Foundation2004Distinguished Young Scholar
    Ellison Medical Research Foundation2001New Scholar Award

    Collapse Overview 
    Collapse Overview
    The laboratory seeks to use big data, high throughput approaches to solve problems caused by infectious diseases. Ongoing projects involve discovering new starting points for drugs, cheminformatics, using in vitro evolution and whole genome analysis to find new drug targets and genes involved in drug resistance, as well as investigating host pathogen interactions using genomic methods such as RNA-seq. Most work is on malaria parasites but I am interested in other microbes. I enjoy developing and exploiting new technologies and lab members should be comfortable working without a recipe.
    Collapse In The News

    Collapse Research 
    Collapse Research Activities and Funding
    Discovery of long-acting, chemoprotective antimalarial compounds
    NIH R01AI152533Mar 25, 2020 - Feb 28, 2025
    Role: Principal Investigator
    Exploring the parasite genomics of severe falciparum malaria in Mozambique
    NIH R21AI152511Mar 5, 2020 - Feb 28, 2022
    Role: Principal Investigator
    Defining the targets of broad intervention antimalarial agents
    NIH R01AI103058Aug 14, 2013 - Jul 31, 2019
    Role: Principal Investigator
    Investigating the molecular basis of primaquine resistance
    NIH R56AI091832Jul 20, 2011 - Dec 30, 2012
    Role: Principal Investigator
    Discovery of chemically validated malaria liver stage targets
    NIH R01AI090141May 6, 2011 - Jul 31, 2021
    Role: Principal Investigator
    San Diego Center for Systems Biology: From Maps to Models
    NIH P50GM085764Sep 18, 2010 - May 31, 2019
    Role: Co-Investigator
    Functional genomic tools for in vivo study of P. vivax
    NIH R21AI085374Jun 15, 2010 - Nov 30, 2012
    Role: Principal Investigator
    Experimental Annotation of the P. Falciparum Genome
    NIH R01AI059472Jul 1, 2005 - Mar 31, 2011
    Role: Principal Investigator
    Discovery of Allelic Variation in Plasmodium falciparum
    NIH R03AI054687Apr 1, 2003 - Mar 31, 2005
    Role: Principal Investigator
    MESSENGER RNA STABILITY IN SACCHAROMYCES CEREVISIAE
    NIH F32HG000185Oct 1, 1997
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Transforming the Health Research Workforce in Mozambique: Achievements of the Mozambique Institute for Health Education and Research (MIHER) over a 13‑Year Journey. Ann Glob Health. 2024; 90(1):78. Noormahomed EV, Noormahomed S, Cossa M, Joyce N, Miambo RD, Sousa IM, Nhacupe N, Mussá T, Sacarlal J, Gouveia L, Ferrão LJ, Carrilho C, Ismail M, Smith D, Martin NK, Goyal R, Barrett KE, Afonso SS, Mandane A, Saíde A, Vintuar P, Singo B, Aleixo B, Injage L, Winzeler EA, Correia-de-Sá P, Martins MDRO, Ferrinho P, Patel S, Mocumbi AO, Bickler SW, Benson CA, Badaró R, Schooley RT. PMID: 39678200; PMCID: PMC11639690.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    2. Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance. Science. 2024 Nov 29; 386(6725):eadk9893. Luth MR, Godinez-Macias KP, Chen D, Okombo J, Thathy V, Cheng X, Daggupati S, Davies H, Dhingra SK, Economy JM, Edgar RCS, Gomez-Lorenzo MG, Istvan ES, Jado JC, LaMonte GM, Melillo B, Mok S, Narwal SK, Ndiaye T, Ottilie S, Palomo Diaz S, Park H, Peña S, Rocamora F, Sakata-Kato T, Small-Saunders JL, Summers RL, Tumwebaze PK, Vanaerschot M, Xia G, Yeo T, You A, Gamo FJ, Goldberg DE, Lee MCS, McNamara CW, Ndiaye D, Rosenthal PJ, Schreiber SL, Serra G, De Siqueira-Neto JL, Skinner-Adams TS, Uhlemann AC, Kato N, Lukens AK, Wirth DF, Fidock DA, Winzeler EA. PMID: 39607932.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining. Res Sq. 2024 Nov 26. Godinez-Macias KP, Chen D, Wallis JL, Siegel MG, Adam A, Bopp S, Carolino K, Coulson LB, Durst G, Thathy V, Esherick L, Farringer MA, Flannery EL, Forte B, Liu T, Magalhaes LG, Gupta AK, Istvan ES, Jiang T, Kumpornsin K, Lobb K, McLean K, Moura IMR, Okombo J, Payne NC, Plater A, Rao SPS, Siqueira-Neto JL, Somsen BA, Summers RL, Zhang R, Gilson MK, Gamo FJ, Campo B, Baragaña B, Duffy J, Gilbert IH, Lukens AK, Dechering KJ, Niles JC, McNamara CW, Cheng X, Birkholtz LM, Bronkhorst AW, Fidock DA, Wirth DF, Goldberg DE, Lee MCS, Winzeler EA. PMID: 39649165; PMCID: PMC11623766.
      View in: PubMed   Mentions:
    4. Tambjamines as Fast-Acting Multistage Antimalarials. ACS Infect Dis. 2024 Dec 13; 10(12):4291-4300. Kumar A, Li Y, Dodean RA, Roth A, Caridha D, Madejczyk MS, Jin X, Dennis WE, Lee PJ, Pybus BS, Martin M, Pannone K, Dinh HT, Blount C, Chetree R, DeLuca J, Evans M, Nadeau R, Vuong C, Leed S, Black C, Sousa J, Nolan C, Ceja FG, Rasmussen SA, Tumwebaze PK, Rosenthal PJ, Cooper RA, Rottmann M, Orjuela-Sanchez P, Meister S, Winzeler EA, Delves MJ, Matthews H, Baum J, Kirby RW, Burrows JN, Duffy J, Peyton DH, Reynolds KA, Kelly JX, Kancharla P. PMID: 39526703; PMCID: PMC11645189.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Author Correction: Antimalarial drug discovery: progress and approaches. Nat Rev Drug Discov. 2024 Nov; 23(11):880. Siqueira-Neto JL, Wicht KJ, Chibale K, Burrows JN, Fidock DA, Winzeler EA. PMID: 39271962.
      View in: PubMed   Mentions:    Fields:    
    6. Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b. Eur J Med Chem. 2024 Dec 15; 280:116921. Awalt JK, Su W, Nguyen W, Loi K, Jarman KE, Penington JS, Ramesh S, Fairhurst KJ, Yeo T, Park H, Uhlemann AC, Chandra Maity B, De N, Mukherjee P, Chakraborty A, Churchyard A, Famodimu MT, Delves MJ, Baum J, Mittal N, Winzeler EA, Papenfuss AT, Chowdury M, de Koning-Ward TF, Maier AG, van Dooren GG, Baud D, Brand S, Fidock DA, Jackson PF, Cowman AF, Dans MG, Sleebs BE. PMID: 39388903; PMCID: PMC11609934.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. Plasmodium SEY1 is a novel druggable target that contributes to imidazolopiperazine mechanism of action. Res Sq. 2024 Sep 23. Winzeler E, Carolino K, De Souza ML, Chen D, Farre JC, Blauwkamp J, Absalon S, Ghidelli-Disse S, Morano A, Dvorin J, Lafuente-Monasterio MJ, Gamo FJ. PMID: 39399671; PMCID: PMC11469372.
      View in: PubMed   Mentions:
    8. Development of peptoid-based heteroaryl-decorated histone deacetylase (HDAC) inhibitors with dual-stage antiplasmodial activity. Eur J Med Chem. 2024 Nov 05; 277:116782. Stopper D, de Carvalho LP, de Souza ML, Kponomaizoun CE, Winzeler EA, Held J, Hansen FK. PMID: 39208744.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. CACTI: an in silico chemical analysis tool through the integration of chemogenomic data and clustering analysis. J Cheminform. 2024 Jul 24; 16(1):84. Godinez-Macias KP, Winzeler EA. PMID: 39049122; PMCID: PMC11270953.
      View in: PubMed   Mentions:
    10. In vitro evolution and whole genome analysis to study chemotherapy drug resistance in haploid human cells. Sci Rep. 2024 06 18; 14(1):13989. Jado JC, Dow M, Carolino K, Klie A, Fonseca GJ, Ideker T, Carter H, Winzeler EA. PMID: 38886371; PMCID: PMC11183241.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. Understanding the Antiplasmodial Action of Resistance-Refractory Xanthoquinodin A1. ACS Infect Dis. 2024 Jun 14; 10(6):2276-2287. Collins JE, Jiang T, Lee JW, Wendt K, Nardella F, Jeon J, Paes R, Santos NM, Rocamora F, Chang M, Schaefer S, Cichewicz RH, Winzeler EA, Chakrabarti D. PMID: 38810215; PMCID: PMC11533362.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    12. Identification of fungal natural products with potent inhibition in Toxoplasma gondii. Microbiol Spectr. 2024 Apr 02; 12(4):e0414223. Jiang T, Godinez-Macias KP, Collins JE, Lee JW, Wendt KL, Carolino K, Chakrabarti D, Cichewicz RH, Winzeler EA. PMID: 38421191; PMCID: PMC10986609.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    13. Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nat Commun. 2024 Jan 31; 15(1):937. Xie SC, Wang Y, Morton CJ, Metcalfe RD, Dogovski C, Pasaje CFA, Dunn E, Luth MR, Kumpornsin K, Istvan ES, Park JS, Fairhurst KJ, Ketprasit N, Yeo T, Yildirim O, Bhebhe MN, Klug DM, Rutledge PJ, Godoy LC, Dey S, De Souza ML, Siqueira-Neto JL, Du Y, Puhalovich T, Amini M, Shami G, Loesbanluechai D, Nie S, Williamson N, Jana GP, Maity BC, Thomson P, Foley T, Tan DS, Niles JC, Han BW, Goldberg DE, Burrows J, Fidock DA, Lee MCS, Winzeler EA, Griffin MDW, Todd MH, Tilley L. PMID: 38297033; PMCID: PMC10831071.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    14. Discovery of Potent Antimalarial Type II Kinase Inhibitors with Selectivity over Human Kinases. J Med Chem. 2024 01 25; 67(2):1460-1480. Wang L, Bohmer MJ, Wang J, Nardella F, Calla J, Laureano De Souza M, Schindler KA, Montejo L, Mittal N, Rocamora F, Treat M, Charlton JT, Tumwebaze PK, Rosenthal PJ, Cooper RA, Chakrabarti R, Winzeler EA, Chakrabarti D, Gray NS. PMID: 38214254; PMCID: PMC10950204.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    15. Antiplasmodial peptaibols act through membrane directed mechanisms. Cell Chem Biol. 2024 Feb 15; 31(2):312-325.e9. Collins JE, Lee JW, Rocamora F, Saggu GS, Wendt KL, Pasaje CFA, Smick S, Santos NM, Paes R, Jiang T, Mittal N, Luth MR, Chin T, Chang H, McLellan JL, Morales-Hernandez B, Hanson KK, Niles JC, Desai SA, Winzeler EA, Cichewicz RH, Chakrabarti D. PMID: 37995692; PMCID: PMC10923054.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Whole-genome surveillance identifies markers of Plasmodium falciparum drug resistance and novel genomic regions under selection in Mozambique. mBio. 2023 Oct 31; 14(5):e0176823. Coonahan E, Gage H, Chen D, Noormahomed EV, Buene TP, Mendes de Sousa I, Akrami K, Chambal L, Schooley RT, Winzeler EA, Cowell AN. PMID: 37750720; PMCID: PMC10653802.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    17. Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance. Elife. 2023 Sep 22; 12. Mandt REK, Luth MR, Tye MA, Mazitschek R, Ottilie S, Winzeler EA, Lafuente-Monasterio MJ, Gamo FJ, Wirth DF, Lukens AK. PMID: 37737220; PMCID: PMC10695565.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    18. Antimalarial drug discovery: progress and approaches. Nat Rev Drug Discov. 2023 10; 22(10):807-826. Siqueira-Neto JL, Wicht KJ, Chibale K, Burrows JN, Fidock DA, Winzeler EA. PMID: 37652975; PMCID: PMC10543600.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    19. Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Res Sq. 2023 Jul 27. Xie SC, Wang Y, Morton CJ, Metcalfe RD, Dogovski C, Pasaje CFA, Dunn E, Luth MR, Kumpornsin K, Istvan ES, Park JS, Fairhurst KJ, Ketprasit N, Yeo T, Yildirim O, Bhebhe MN, Klug DM, Rutledge PJ, Godoy LC, Dey S, De Souza ML, Siqueira-Neto JL, Du Y, Puhalovich T, Amini M, Shami G, Loesbanluechai D, Nie S, Williamson N, Jana GP, Maity BC, Thomson P, Foley T, Tan DS, Niles JC, Han BW, Goldberg DE, Burrows J, Fidock DA, Lee MCS, Winzeler EA, Griffin MDW, Todd MH, Tilley L. PMID: 37546892; PMCID: PMC10402266.
      View in: PubMed   Mentions:
    20. Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum. Nat Commun. 2023 05 27; 14(1):3059. Kümpornsin K, Kochakarn T, Yeo T, Okombo J, Luth MR, Hoshizaki J, Rawat M, Pearson RD, Schindler KA, Mok S, Park H, Uhlemann AC, Jana GP, Maity BC, Laleu B, Chenu E, Duffy J, Moliner Cubel S, Franco V, Gomez-Lorenzo MG, Gamo FJ, Winzeler EA, Fidock DA, Chookajorn T, Lee MCS. PMID: 37244916; PMCID: PMC10224993.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    21. Human nuclear hormone receptor activity contributes to malaria parasite liver stage development. Cell Chem Biol. 2023 05 18; 30(5):486-498.e7. Mittal N, Davis C, McLean P, Calla J, Godinez-Macias KP, Gardner A, Healey D, Orjuela-Sanchez P, Ottilie S, Chong Y, Gibson C, Winzeler EA. PMID: 37172592; PMCID: PMC10878326.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    22. Targeting Aminoacyl tRNA Synthetases for Antimalarial Drug Development. Annu Rev Microbiol. 2023 09 15; 77:111-129. Xie SC, Griffin MDW, Winzeler EA, Ribas de Pouplana L, Tilley L. PMID: 37018842.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    23. Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation. Nat Commun. 2023 03 16; 14(1):1455. Bopp S, Pasaje CFA, Summers RL, Magistrado-Coxen P, Schindler KA, Corpas-Lopez V, Yeo T, Mok S, Dey S, Smick S, Nasamu AS, Demas AR, Milne R, Wiedemar N, Corey V, Gomez-Lorenzo MG, Franco V, Early AM, Lukens AK, Milner D, Furtado J, Gamo FJ, Winzeler EA, Volkman SK, Duffey M, Laleu B, Fidock DA, Wyllie S, Niles JC, Wirth DF. PMID: 36927839; PMCID: PMC10020447.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    24. Human Polo-like Kinase Inhibitors as Antiplasmodials. ACS Infect Dis. 2023 04 14; 9(4):1004-1021. Bohmer MJ, Wang J, Istvan ES, Luth MR, Collins JE, Huttlin EL, Wang L, Mittal N, Hao M, Kwiatkowski NP, Gygi SP, Chakrabarti R, Deng X, Goldberg DE, Winzeler EA, Gray NS, Chakrabarti D. PMID: 36919909; PMCID: PMC10106425.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    25. Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target. Sci Transl Med. 2023 03 08; 15(686):eadc9249. Istvan ES, Guerra F, Abraham M, Huang KS, Rocamora F, Zhao H, Xu L, Pasaje C, Kumpornsin K, Luth MR, Cui H, Yang T, Palomo Diaz S, Gomez-Lorenzo MG, Qahash T, Mittal N, Ottilie S, Niles J, Lee MCS, Llinas M, Kato N, Okombo J, Fidock DA, Schimmel P, Gamo FJ, Goldberg DE, Winzeler EA. PMID: 36888694; PMCID: PMC10286833.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    26. Development of Potent and Highly Selective Epoxyketone-Based Plasmodium Proteasome Inhibitors. Chemistry. 2023 Apr 06; 29(20):e202203958. Almaliti J, Fajtová P, Calla J, LaMonte GM, Feng M, Rocamora F, Ottilie S, Glukhov E, Boura E, Suhandynata RT, Momper JD, Gilson MK, Winzeler EA, Gerwick WH, O'Donoghue AJ. PMID: 36617500; PMCID: PMC10894724.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    27. 7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc1 Complex. ACS Infect Dis. 2023 03 10; 9(3):668-691. Nguyen W, Dans MG, Currie I, Awalt JK, Bailey BL, Lumb C, Ngo A, Favuzza P, Palandri J, Ramesh S, Penington J, Jarman KE, Mukherjee P, Chakraborty A, Maier AG, van Dooren GG, Papenfuss T, Wittlin S, Churchyard A, Baum J, Winzeler EA, Baud D, Brand S, Jackson PF, Cowman AF, Sleebs BE. PMID: 36853190; PMCID: PMC10012268.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    28. Fast-Killing Tyrosine Amide ((S)-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus (PfCARL). ACS Infect Dis. 2023 03 10; 9(3):527-539. Imlay LS, Lawong AK, Gahalawat S, Kumar A, Xing C, Mittal N, Wittlin S, Churchyard A, Niederstrasser H, Crespo-Fernandez B, Posner BA, Gamo FJ, Baum J, Winzeler EA, Laleu B, Ready JM, Phillips MA. PMID: 36763526; PMCID: PMC10053980.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    29. The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages. Sci Transl Med. 2022 10 19; 14(667):eabo7219. Arendse LB, Murithi JM, Qahash T, Pasaje CFA, Godoy LC, Dey S, Gibhard L, Ghidelli-Disse S, Drewes G, Bantscheff M, Lafuente-Monasterio MJ, Fienberg S, Wambua L, Gachuhi S, Coertzen D, van der Watt M, Reader J, Aswat AS, Erlank E, Venter N, Mittal N, Luth MR, Ottilie S, Winzeler EA, Koekemoer LL, Birkholtz LM, Niles JC, Llinás M, Fidock DA, Chibale K. PMID: 36260689; PMCID: PMC9951552.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    30. Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2. ChemMedChem. 2022 11 18; 17(22):e202200393. Laleu B, Rubiano K, Yeo T, Hallyburton I, Anderson M, Crespo-Fernandez B, Gamo FJ, Antonova-Koch Y, Orjuela-Sanchez P, Wittlin S, Jana GP, Maity BC, Chenu E, Duffy J, Sjö P, Waterson D, Winzeler E, Guantai E, Fidock DA, Hansson TG. PMID: 36129427; PMCID: PMC9827907.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    31. New targets for antimalarial drug discovery. Curr Opin Microbiol. 2022 12; 70:102220. Guerra F, Winzeler EA. PMID: 36228458; PMCID: PMC9934905.
      View in: PubMed   Mentions: 1     Fields:    
    32. Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance. Nat Commun. 2022 08 25; 13(1):4976. Tye MA, Payne NC, Johansson C, Singh K, Santos SA, Fagbami L, Pant A, Sylvester K, Luth MR, Marques S, Whitman M, Mota MM, Winzeler EA, Lukens AK, Derbyshire ER, Oppermann U, Wirth DF, Mazitschek R. PMID: 36008486; PMCID: PMC9403976.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    33. Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy. Science. 2022 06 03; 376(6597):1074-1079. Xie SC, Metcalfe RD, Dunn E, Morton CJ, Huang SC, Puhalovich T, Du Y, Wittlin S, Nie S, Luth MR, Ma L, Kim MS, Pasaje CFA, Kumpornsin K, Giannangelo C, Houghton FJ, Churchyard A, Famodimu MT, Barry DC, Gillett DL, Dey S, Kosasih CC, Newman W, Niles JC, Lee MCS, Baum J, Ottilie S, Winzeler EA, Creek DJ, Williamson N, Parker MW, Brand S, Langston SP, Dick LR, Griffin MDW, Gould AE, Tilley L. PMID: 35653481; PMCID: PMC7613620.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    34. Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer. Front Pharmacol. 2022; 13:875647. Abacha YZ, Forkuo AD, Gbedema SY, Mittal N, Ottilie S, Rocamora F, Winzeler EA, van Schalkwyk DA, Kelly JM, Taylor MC, Reader J, Birkholtz LM, Lisgarten DR, Cockcroft JK, Lisgarten JN, Palmer RA, Talbert RC, Shnyder SD, Wright CW. PMID: 35600849; PMCID: PMC9119314.
      View in: PubMed   Mentions: 1  
    35. A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum. PLoS Pathog. 2022 03; 18(3):e1010409. Beutler N, Pholcharee T, Oyen D, Flores-Garcia Y, MacGill RS, Garcia E, Calla J, Parren M, Yang L, Volkmuth W, Locke E, Regules JA, Dutta S, Emerling D, Early AM, Neafsey DE, Winzeler EA, King CR, Zavala F, Burton DR, Wilson IA, Rogers TF. PMID: 35344575; PMCID: PMC8989322.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    36. Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance. Commun Biol. 2022 02 11; 5(1):128. Ottilie S, Luth MR, Hellemann E, Goldgof GM, Vigil E, Kumar P, Cheung AL, Song M, Godinez-Macias KP, Carolino K, Yang J, Lopez G, Abraham M, Tarsio M, LeBlanc E, Whitesell L, Schenken J, Gunawan F, Patel R, Smith J, Love MS, Williams RM, McNamara CW, Gerwick WH, Ideker T, Suzuki Y, Wirth DF, Lukens AK, Kane PM, Cowen LE, Durrant JD, Winzeler EA. PMID: 35149760; PMCID: PMC8837787.
      View in: PubMed   Mentions: 10  Translation:Animals
    37. Tres Cantos Open Lab: celebrating a decade of innovation in collaboration to combat endemic infectious diseases. Nat Rev Drug Discov. 2021 11; 20(11):799-800. Calderón F, Ballell L, Barros D, Bilbe G, Cammack N, Gabarró R, Halsey A, Heaton PM, Kang G, Mizrahi V, Nathan C, Strange ME, Williams PM, Winzeler EA, Fairlamb AH. PMID: 34471283.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    38. Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome. Proc Natl Acad Sci U S A. 2021 09 28; 118(39). Xie SC, Metcalfe RD, Mizutani H, Puhalovich T, Hanssen E, Morton CJ, Du Y, Dogovski C, Huang SC, Ciavarri J, Hales P, Griffin RJ, Cohen LH, Chuang BC, Wittlin S, Deni I, Yeo T, Ward KE, Barry DC, Liu B, Gillett DL, Crespo-Fernandez BF, Ottilie S, Mittal N, Churchyard A, Ferguson D, Aguiar ACC, Guido RVC, Baum J, Hanson KK, Winzeler EA, Gamo FJ, Fidock DA, Baud D, Parker MW, Brand S, Dick LR, Griffin MDW, Gould AE, Tilley L. PMID: 34548400; PMCID: PMC8488693.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    39. Prioritization of Molecular Targets for Antimalarial Drug Discovery. ACS Infect Dis. 2021 10 08; 7(10):2764-2776. Forte B, Ottilie S, Plater A, Campo B, Dechering KJ, Gamo FJ, Goldberg DE, Istvan ES, Lee M, Lukens AK, McNamara CW, Niles JC, Okombo J, Pasaje CFA, Siegel MG, Wirth D, Wyllie S, Fidock DA, Baragaña B, Winzeler EA, Gilbert IH. PMID: 34523908; PMCID: PMC8608365.
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    183. Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biol. 2009 Feb 13; 10(2):R21. Dharia NV, Sidhu AB, Cassera MB, Westenberger SJ, Bopp SE, Eastman RT, Plouffe D, Batalov S, Park DJ, Volkman SK, Wirth DF, Zhou Y, Fidock DA, Winzeler EA. PMID: 19216790; PMCID: PMC2688282.
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    184. A systematic approach to understand the mechanism of action of the bisthiazolium compound T4 on the human malaria parasite, Plasmodium falciparum. BMC Genomics. 2008 Oct 30; 9:513. Le Roch KG, Johnson JR, Ahiboh H, Chung DW, Prudhomme J, Plouffe D, Henson K, Zhou Y, Witola W, Yates JR, Mamoun CB, Winzeler EA, Vial H. PMID: 18973684; PMCID: PMC2596145.
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    185. Malaria research in the post-genomic era. Nature. 2008 Oct 09; 455(7214):751-6. Winzeler EA. PMID: 18843360; PMCID: PMC2705782.
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    186. In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proc Natl Acad Sci U S A. 2008 Jul 01; 105(26):9059-64. Plouffe D, Brinker A, McNamara C, Henson K, Kato N, Kuhen K, Nagle A, Adrián F, Matzen JT, Anderson P, Nam TG, Gray NS, Chatterjee A, Janes J, Yan SF, Trager R, Caldwell JS, Schultz PG, Zhou Y, Winzeler EA. PMID: 18579783; PMCID: PMC2440361.
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    187. Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat Chem Biol. 2008 Jun; 4(6):347-56. Kato N, Sakata T, Breton G, Le Roch KG, Nagle A, Andersen C, Bursulaya B, Henson K, Johnson J, Kumar KA, Marr F, Mason D, McNamara C, Plouffe D, Ramachandran V, Spooner M, Tuntland T, Zhou Y, Peters EC, Chatterjee A, Schultz PG, Ward GE, Gray N, Harper J, Winzeler EA. PMID: 18454143.
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    188. Evidence-based annotation of the malaria parasite's genome using comparative expression profiling. PLoS One. 2008 Feb 13; 3(2):e1570. Zhou Y, Ramachandran V, Kumar KA, Westenberger S, Refour P, Zhou B, Li F, Young JA, Chen K, Plouffe D, Henson K, Nussenzweig V, Carlton J, Vinetz JM, Duraisingh MT, Winzeler EA. PMID: 18270564; PMCID: PMC2215772.
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    189. In silico discovery of transcription regulatory elements in Plasmodium falciparum. BMC Genomics. 2008 Feb 07; 9:70. Young JA, Johnson JR, Benner C, Yan SF, Chen K, Le Roch KG, Zhou Y, Winzeler EA. PMID: 18257930; PMCID: PMC2268928.
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    190. Distinct physiological states of Plasmodium falciparum in malaria-infected patients. Nature. 2007 Dec 13; 450(7172):1091-5. Daily JP, Scanfeld D, Pochet N, Le Roch K, Plouffe D, Kamal M, Sarr O, Mboup S, Ndir O, Wypij D, Levasseur K, Thomas E, Tamayo P, Dong C, Zhou Y, Lander ES, Ndiaye D, Wirth D, Winzeler EA, Mesirov JP, Regev A. PMID: 18046333.
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    191. Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite. Cell. 2007 Nov 02; 131(3):492-504. Singh AP, Buscaglia CA, Wang Q, Levay A, Nussenzweig DR, Walker JR, Winzeler EA, Fujii H, Fontoura BM, Nussenzweig V. PMID: 17981117.
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    192. Genomics, systems biology and drug development for infectious diseases. Mol Biosyst. 2007 Dec; 3(12):841-8. Sakata T, Winzeler EA. PMID: 18000561.
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    193. Mechanisms of gene regulation in Plasmodium. Am J Trop Med Hyg. 2007 Aug; 77(2):201-8. Deitsch K, Duraisingh M, Dzikowski R, Gunasekera A, Khan S, Le Roch K, Llinás M, Mair G, McGovern V, Roos D, Shock J, Sims J, Wiegand R, Winzeler E. PMID: 17690387.
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    194. Exposure of Plasmodium sporozoites to the intracellular concentration of potassium enhances infectivity and reduces cell passage activity. Mol Biochem Parasitol. 2007 Nov; 156(1):32-40. Kumar KA, Garcia CR, Chandran VR, Van Rooijen N, Zhou Y, Winzeler E, Nussenzweig V. PMID: 17714805.
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    195. Large-scale annotation of small-molecule libraries using public databases. J Chem Inf Model. 2007 Jul-Aug; 47(4):1386-94. Zhou Y, Zhou B, Chen K, Yan SF, King FJ, Jiang S, Winzeler EA. PMID: 17608408.
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    196. Plasmodium falciparum: genome wide perturbations in transcript profiles among mixed stage cultures after chloroquine treatment. Exp Parasitol. 2007 Sep; 117(1):87-92. Gunasekera AM, Myrick A, Le Roch K, Winzeler E, Wirth DF. PMID: 17475254.
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    197. Regulatory motifs uncovered among gene expression clusters in Plasmodium falciparum. Mol Biochem Parasitol. 2007 May; 153(1):19-30. Gunasekera AM, Myrick A, Militello KT, Sims JS, Dong CK, Gierahn T, Le Roch K, Winzeler E, Wirth DF. PMID: 17307259.
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    198. Using the genome to dissect the molecular basis of drug resistance. Future Microbiol. 2006 Aug; 1(2):185-99. Kidgell C, Winzeler EA. PMID: 17661664.
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    199. A systematic map of genetic variation in Plasmodium falciparum. PLoS Pathog. 2006 Jun; 2(6):e57. Kidgell C, Volkman SK, Daily J, Borevitz JO, Plouffe D, Zhou Y, Johnson JR, Le Roch K, Sarr O, Ndir O, Mboup S, Batalov S, Wirth DF, Winzeler EA. PMID: 16789840; PMCID: PMC1480597.
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    200. Applied systems biology and malaria. Nat Rev Microbiol. 2006 Feb; 4(2):145-51. Winzeler EA. PMID: 16362033.
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    201. Microarray-based comparative genomic analyses of the human malaria parasite Plasmodium falciparum using Affymetrix arrays. Mol Biochem Parasitol. 2005 Dec; 144(2):177-86. Carret CK, Horrocks P, Konfortov B, Winzeler E, Qureshi M, Newbold C, Ivens A. PMID: 16174539.
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    202. The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification. Mol Biochem Parasitol. 2005 Sep; 143(1):67-79. Young JA, Fivelman QL, Blair PL, de la Vega P, Le Roch KG, Zhou Y, Carucci DJ, Baker DA, Winzeler EA. PMID: 16005087.
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    203. Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes. Science. 2005 Aug 26; 309(5739):1384-7. Stubbs J, Simpson KM, Triglia T, Plouffe D, Tonkin CJ, Duraisingh MT, Maier AG, Winzeler EA, Cowman AF. PMID: 16123303.
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    204. A comparison of match-only algorithms for the analysis of Plasmodium falciparum oligonucleotide arrays. Int J Parasitol. 2005 Apr 30; 35(5):523-31. Simpson KM, Baum J, Good RT, Winzeler EA, Cowman AF, Speed TP. PMID: 15826644.
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    205. In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins. J Infect Dis. 2005 Apr 01; 191(7):1196-203. Daily JP, Le Roch KG, Sarr O, Ndiaye D, Lukens A, Zhou Y, Ndir O, Mboup S, Sultan A, Winzeler EA, Wirth DF. PMID: 15747257; PMCID: PMC2582152.
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    206. Elucidating genetic diversity with oligonucleotide arrays. Chromosome Res. 2005; 13(3):225-35. Kidgell C, Winzeler EA. PMID: 15868417; PMCID: PMC7088299.
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    207. Using expression information to discover new drug and vaccine targets in the malaria parasite Plasmodium falciparum. Pharmacogenomics. 2005 Jan; 6(1):17-26. Young JA, Winzeler EA. PMID: 15723602.
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    208. Coordinated functions of WSS1, PSY2 and TOF1 in the DNA damage response. Nucleic Acids Res. 2004; 32(22):6519-30. O'Neill BM, Hanway D, Winzeler EA, Romesberg FE. PMID: 15598824; PMCID: PMC545462.
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    209. In silico gene function prediction using ontology-based pattern identification. Bioinformatics. 2005 Apr 01; 21(7):1237-45. Zhou Y, Young JA, Santrosyan A, Chen K, Yan SF, Winzeler EA. PMID: 15531612.
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    210. Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle. Genome Res. 2004 Nov; 14(11):2308-18. Le Roch KG, Johnson JR, Florens L, Zhou Y, Santrosyan A, Grainger M, Yan SF, Williamson KC, Holder AA, Carucci DJ, Yates JR, Winzeler EA. PMID: 15520293; PMCID: PMC525690.
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    211. In vivo transcriptional profiling of Plasmodium falciparum. Malar J. 2004 Aug 05; 3:30. Daily JP, Le Roch KG, Sarr O, Fang X, Zhou Y, Ndir O, Mboup S, Sultan A, Winzeler EA, Wirth DF. PMID: 15296511; PMCID: PMC514566.
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    212. A Plasmodium gene family encoding Maurer's cleft membrane proteins: structural properties and expression profiling. Genome Res. 2004 Jun; 14(6):1052-9. Sam-Yellowe TY, Florens L, Johnson JR, Wang T, Drazba JA, Le Roch KG, Zhou Y, Batalov S, Carucci DJ, Winzeler EA, Yates JR. PMID: 15140830; PMCID: PMC419783.
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    213. Leveraging two-way probe-level block design for identifying differential gene expression with high-density oligonucleotide arrays. BMC Bioinformatics. 2004 Apr 20; 5:42. Barrera L, Benner C, Tao YC, Winzeler E, Zhou Y. PMID: 15099405; PMCID: PMC411067.
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    214. Discovery of gene function by expression profiling of the malaria parasite life cycle. Science. 2003 Sep 12; 301(5639):1503-8. Le Roch KG, Zhou Y, Blair PL, Grainger M, Moch JK, Haynes JD, De La Vega P, Holder AA, Batalov S, Carucci DJ, Winzeler EA. PMID: 12893887.
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    215. Protein pathway and complex clustering of correlated mRNA and protein expression analyses in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3107-12. Washburn MP, Koller A, Oshiro G, Ulaszek RR, Plouffe D, Deciu C, Winzeler E, Yates JR. PMID: 12626741; PMCID: PMC152254.
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    216. Large-scale identification of single-feature polymorphisms in complex genomes. Genome Res. 2003 Mar; 13(3):513-23. Borevitz JO, Liang D, Plouffe D, Chang HS, Zhu T, Weigel D, Berry CC, Winzeler E, Chory J. PMID: 12618383; PMCID: PMC430246.
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    217. Genetic diversity in yeast assessed with whole-genome oligonucleotide arrays. Genetics. 2003 Jan; 163(1):79-89. Winzeler EA, Castillo-Davis CI, Oshiro G, Liang D, Richards DR, Zhou Y, Hartl DL. PMID: 12586698; PMCID: PMC1462430.
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    218. The Ume6 regulon coordinates metabolic and meiotic gene expression in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13431-6. Williams RM, Primig M, Washburn BK, Winzeler EA, Bellis M, Sarrauste de Menthiere C, Davis RW, Esposito RE. PMID: 12370439; PMCID: PMC129690.
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    219. Excess polymorphisms in genes for membrane proteins in Plasmodium falciparum. Science. 2002 Oct 04; 298(5591):216-8. Volkman SK, Hartl DL, Wirth DF, Nielsen KM, Choi M, Batalov S, Zhou Y, Plouffe D, Le Roch KG, Abagyan R, Winzeler EA. PMID: 12364807.
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    220. Monitoring the chromosome 2 intraerythrocytic transcriptome of Plasmodium falciparum using oligonucleotide arrays. Am J Trop Med Hyg. 2002 Sep; 67(3):233-43. Le Roch KG, Zhou Y, Batalov S, Winzeler EA. PMID: 12408661.
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    221. Treasures and traps in genome-wide data sets: case examples from yeast. Nat Rev Genet. 2002 Sep; 3(9):653-61. Grünenfelder B, Winzeler EA. PMID: 12209140.
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    222. Parallel identification of new genes in Saccharomyces cerevisiae. Genome Res. 2002 Aug; 12(8):1210-20. Oshiro G, Wodicka LM, Washburn MP, Yates JR, Lockhart DJ, Winzeler EA. PMID: 12176929; PMCID: PMC186640.
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    223. Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10605-10. Hanway D, Chin JK, Xia G, Oshiro G, Winzeler EA, Romesberg FE. PMID: 12149442; PMCID: PMC124988.
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    224. Functional profiling of the Saccharomyces cerevisiae genome. Nature. 2002 Jul 25; 418(6896):387-91. Giaever G, Chu AM, Ni L, Connelly C, Riles L, Véronneau S, Dow S, Lucau-Danila A, Anderson K, André B, Arkin AP, Astromoff A, El-Bakkoury M, Bangham R, Benito R, Brachat S, Campanaro S, Curtiss M, Davis K, Deutschbauer A, Entian KD, Flaherty P, Foury F, Garfinkel DJ, Gerstein M, Gotte D, Güldener U, Hegemann JH, Hempel S, Herman Z, Jaramillo DF, Kelly DE, Kelly SL, Kötter P, LaBonte D, Lamb DC, Lan N, Liang H, Liao H, Liu L, Luo C, Lussier M, Mao R, Menard P, Ooi SL, Revuelta JL, Roberts CJ, Rose M, Ross-Macdonald P, Scherens B, Schimmack G, Shafer B, Shoemaker DD, Sookhai-Mahadeo S, Storms RK, Strathern JN, Valle G, Voet M, Volckaert G, Wang CY, Ward TR, Wilhelmy J, Winzeler EA, Yang Y, Yen G, Youngman E, Yu K, Bussey H, Boeke JD, Snyder M, Philippsen P, Davis RW, Johnston M. PMID: 12140549.
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    225. The paradoxical population genetics of Plasmodium falciparum. Trends Parasitol. 2002 Jun; 18(6):266-72. Hartl DL, Volkman SK, Nielsen KM, Barry AE, Day KP, Wirth DF, Winzeler EA. PMID: 12036741.
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    226. Application of high-density array-based signature-tagged mutagenesis to discover novel Yersinia virulence-associated genes. Infect Immun. 2001 Dec; 69(12):7810-9. Karlyshev AV, Oyston PC, Williams K, Clark GC, Titball RW, Winzeler EA, Wren BW. PMID: 11705963; PMCID: PMC98877.
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    227. Replication dynamics of the yeast genome. Science. 2001 Oct 05; 294(5540):115-21. Raghuraman MK, Winzeler EA, Collingwood D, Hunt S, Wodicka L, Conway A, Lockhart DJ, Davis RW, Brewer BJ, Fangman WL. PMID: 11588253.
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    228. The core meiotic transcriptome in budding yeasts. Nat Genet. 2000 Dec; 26(4):415-23. Primig M, Williams RM, Winzeler EA, Tevzadze GG, Conway AR, Hwang SY, Davis RW, Esposito RE. PMID: 11101837.
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    229. Aneuploidy--it's more common than you think. Nat Biotechnol. 2000 Jul; 18(7):715-6. Oshiro G, Winzeler EA. PMID: 10888835.
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    230. Genomics, gene expression and DNA arrays. Nature. 2000 Jun 15; 405(6788):827-36. Lockhart DJ, Winzeler EA. PMID: 10866209.
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    231. Functional analysis of the yeast genome by precise deletion and parallel phenotypic characterization. Novartis Found Symp. 2000; 229:105-9; discussion 109-11. Winzeler EA, Liang H, Shoemaker DD, Davis RW. PMID: 11084935.
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    232. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science. 1999 Aug 06; 285(5429):901-6. Winzeler EA, Shoemaker DD, Astromoff A, Liang H, Anderson K, Andre B, Bangham R, Benito R, Boeke JD, Bussey H, Chu AM, Connelly C, Davis K, Dietrich F, Dow SW, El Bakkoury M, Foury F, Friend SH, Gentalen E, Giaever G, Hegemann JH, Jones T, Laub M, Liao H, Liebundguth N, Lockhart DJ, Lucau-Danila A, Lussier M, M'Rabet N, Menard P, Mittmann M, Pai C, Rebischung C, Revuelta JL, Riles L, Roberts CJ, Ross-MacDonald P, Scherens B, Snyder M, Sookhai-Mahadeo S, Storms RK, Véronneau S, Voet M, Volckaert G, Ward TR, Wysocki R, Yen GS, Yu K, Zimmermann K, Philippsen P, Johnston M, Davis RW. PMID: 10436161.
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    233. Genomic profiling of drug sensitivities via induced haploinsufficiency. Nat Genet. 1999 Mar; 21(3):278-83. Giaever G, Shoemaker DD, Jones TW, Liang H, Winzeler EA, Astromoff A, Davis RW. PMID: 10080179.
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    234. Whole genome genetic-typing in yeast using high-density oligonucleotide arrays. Parasitology. 1999; 118 Suppl:S73-80. Winzeler EA, Lee B, McCusker JH, Davis RW. PMID: 10466139.
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    235. Fluorescence-based expression monitoring using microarrays. Methods Enzymol. 1999; 306:3-18. Winzeler EA, Schena M, Davis RW. PMID: 10432445.
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    236. Direct allelic variation scanning of the yeast genome. Science. 1998 Aug 21; 281(5380):1194-7. Winzeler EA, Richards DR, Conway AR, Goldstein AL, Kalman S, McCullough MJ, McCusker JH, Stevens DA, Wodicka L, Lockhart DJ, Davis RW. PMID: 9712584.
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    237. A genome-wide transcriptional analysis of the mitotic cell cycle. Mol Cell. 1998 Jul; 2(1):65-73. Cho RJ, Campbell MJ, Winzeler EA, Steinmetz L, Conway A, Wodicka L, Wolfsberg TG, Gabrielian AE, Landsman D, Lockhart DJ, Davis RW. PMID: 9702192.
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    238. Functional analysis of the yeast genome. Curr Opin Genet Dev. 1997 Dec; 7(6):771-6. Winzeler EA, Davis RW. PMID: 9468786.
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    239. Transcriptional analysis of the Caulobacter 4.5 S RNA ffs gene and the physiological basis of an ffs mutant with a Ts phenotype. J Mol Biol. 1997 Oct 10; 272(5):665-76. Winzeler E, Wheeler R, Shapiro L. PMID: 9368649.
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    240. Translation of the leaderless Caulobacter dnaX mRNA. J Bacteriol. 1997 Jun; 179(12):3981-8. Winzeler E, Shapiro L. PMID: 9190815; PMCID: PMC179208.
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    241. A novel promoter motif for Caulobacter cell cycle-controlled DNA replication genes. J Mol Biol. 1996 Dec 06; 264(3):412-25. Winzeler E, Shapiro L. PMID: 8969294.
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    242. Use of flow cytometry to identify a Caulobacter 4.5 S RNA temperature-sensitive mutant defective in the cell cycle. J Mol Biol. 1995 Aug 18; 251(3):346-65. Winzeler E, Shapiro L. PMID: 7544413.
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    243. Fluorescence anisotropy decay of ethidium bound to nucleosome core particles. 2. The torsional motion of the DNA is highly constrained and sensitive to pH. Biochemistry. 1991 May 28; 30(21):5304-13. Winzeler EA, Small EW. PMID: 2036397.
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