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Adam Engler

Title(s)Professor, Bioengineering
SchoolAcademic Aff
Address9500 Gilman Drive #0695
La Jolla CA 92093
Phone858-246-0678
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    Collapse Research 
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    Biophysical Interrogation of Signals that Drive GBM Invasion
    NIH/NINDS R01NS116802May 1, 2020 - Feb 28, 2025
    Role: Principal Investigator
    Mechanogenetics: An Integrated Approach in Muscle Dysfunction
    NIH/NIA 2R01AG045428Sep 30, 2018 - May 31, 2023
    Role: Principal Investigator
    Collaborative Research: Heterogeneous Cancer Cell Mechanics Differentially Drives Mechanosensing and Migration
    NSF 1763139Sep 15, 2018 - Aug 31, 2021
    Role: Principal Investigator
    Interprofessional Design and Entrepreneurship in Medical Devices at UC San Diego
    NIH/NIBIB R25EB023839Jun 5, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Developing Adhesome Technology as a Physical Marker of Highly Metastatic Cells
    NIH/NCI R21CA217735May 1, 2018 - Apr 30, 2021
    Role: Principal Investigator
    Biomaterial Mimicry of Dynamic Matrix Stiffening During Tumor Progression
    NIH/NCI R01CA206880Jul 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    REU Site: Engineered Materials for Tissue Engineering and Drug Delivery
    NSF 1559781Apr 1, 2016 - Mar 30, 2019
    Role: Principal Investigator
    Strain-Activated Signaling within Cell Adhesions Dictates Cell Fate
    NSF 1463689Apr 1, 2015 - Mar 30, 2018
    Role: Principal Investigator
    Mechanogenetics: An Integrated Approach to Aging in Muscle Dysfunction
    NIH/NIA R01AG045428Sep 30, 2013 - May 31, 2023
    Role: Principal Investigator
    Stem Cells and Dynamic Materials Improve Cardiac Function Post-mycardial Infarcti
    NIH/NHLBI R21HL106529Jul 15, 2011 - Jun 30, 2013
    Role: Principal Investigator
    Improving Endoderm Specification with Hybrid Materials and Growth Factors
    NIH/NIBIB R21EB011727May 1, 2010 - Apr 30, 2013
    Role: Principal Investigator
    "Smart" Materials to Engineer a More Complete Stem Cell Niche
    NIH DP2OD006460Sep 30, 2009 - Jun 30, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex. Dev Cell. 2020 Aug 10; 54(3):302-316.e7. Fattet L, Jung HY, Matsumoto MW, Aubol BE, Kumar A, Adams JA, Chen AC, Sah RL, Engler AJ, Pasquale EB, Yang J. PMID: 32574556.
      View in: PubMed   Mentions: 2     Fields:    
    2. Metabolic Dysregulation of the Lysophospholipid/Autotaxin Axis in the Chromosome 9p21 Gene SNP rs10757274. Circ Genom Precis Med. 2020 Jun; 13(3):e002806. Meckelmann SW, Hawksworth JI, White D, Andrews R, Rodrigues P, O'Connor A, Alvarez-Jarreta J, Tyrrell VJ, Hinz C, Zhou Y, Williams J, Aldrovandi M, Watkins WJ, Engler AJ, Lo Sardo V, Slatter DA, Allen SM, Acharya J, Mitchell J, Cooper J, Aoki J, Kano K, Humphries SE, O'Donnell VB. PMID: 32396387.
      View in: PubMed   Mentions:    Fields:    
    3. Academic vs industry perspectives in 3D bioprinting. APL Bioeng. 2020 Mar; 4(1):010401. Engler AJ, Cooper-White J. PMID: 32161831.
      View in: PubMed   Mentions:
    4. Multi-scale cellular engineering: From molecules to organ-on-a-chip. APL Bioeng. 2020 Mar; 4(1):010906. Huang NF, Chaudhuri O, Cahan P, Wang A, Engler AJ, Wang Y, Kumar S, Khademhosseini A, Li S. PMID: 32161833.
      View in: PubMed   Mentions:
    5. H-Ras Transformation of Mammary Epithelial Cells Induces ERK-Mediated Spreading on Low Stiffness Matrix. Adv Healthc Mater. 2020 04; 9(8):e1901366. Plunkett C, Kumar A, Yrastorza J, Hou YH, Placone JK, Grennan G, Engler AJ. PMID: 31951109.
      View in: PubMed   Mentions: 1     Fields:    
    6. Cell Adhesiveness Serves as a Biophysical Marker for Metastatic Potential. Cancer Res. 2020 02 15; 80(4):901-911. Beri P, Popravko A, Yeoman B, Kumar A, Chen K, Hodzic E, Chiang A, Banisadr A, Placone JK, Carter H, Fraley SI, Katira P, Engler AJ. PMID: 31857292.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. Substrate stiffness directs diverging vascular fates. Acta Biomater. 2019 09 15; 96:321-329. Wong L, Kumar A, Gabela-Zuniga B, Chua J, Singh G, Happe CL, Engler AJ, Fan Y, McCloskey KE. PMID: 31326665.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    8. 3D collagen architecture regulates cell adhesion through degradability, thereby controlling metabolic and oxidative stress. Integr Biol (Camb). 2019 05 01; 11(5):221-234. Velez DO, Ranamukhaarachchi SK, Kumar A, Modi RN, Lim EW, Engler AJ, Metallo CM, Fraley SI. PMID: 31251330.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    9. Mechanical influences on cardiovascular differentiation and disease modeling. Exp Cell Res. 2019 04 15; 377(1-2):103-108. Teng EL, Engler AJ. PMID: 30794804.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. Dynamically stiffened matrix promotes malignant transformation of mammary epithelial cells via collective mechanical signaling. Proc Natl Acad Sci U S A. 2019 02 26; 116(9):3502-3507. Ondeck MG, Kumar A, Placone JK, Plunkett CM, Matte BF, Wong KC, Fattet L, Yang J, Engler AJ. PMID: 30755531.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    11. Combinatorial interactions of genetic variants in human cardiomyopathy. Nat Biomed Eng. 2019 02; 3(2):147-157. Deacon DC, Happe CL, Chen C, Tedeschi N, Manso AM, Li T, Dalton ND, Peng Q, Farah EN, Gu Y, Tenerelli KP, Tran VD, Chen J, Peterson KL, Schork NJ, Adler ED, Engler AJ, Ross RS, Chi NC. PMID: 30923642.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    12. Macromolecular crowding tunes 3D collagen architecture and cell morphogenesis. Biomater Sci. 2019 Jan 29; 7(2):618-633. Ranamukhaarachchi SK, Modi RN, Han A, Velez DO, Kumar A, Engler AJ, Fraley SI. PMID: 30515503.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. Mechanical activation of noncoding-RNA-mediated regulation of disease-associated phenotypes in human cardiomyocytes. Nat Biomed Eng. 2019 Feb; 3(2):137-146. Kumar A, Thomas SK, Wong KC, Lo Sardo V, Cheah DS, Hou YH, Placone JK, Tenerelli KP, Ferguson WC, Torkamani A, Topol EJ, Baldwin KK, Engler AJ. PMID: 30911429.
      View in: PubMed   Mentions: 5     Fields:    
    14. Matrix stiffness mechanically conditions EMT and migratory behavior of oral squamous cell carcinoma. J Cell Sci. 2019 01 09; 132(1). Matte BF, Kumar A, Placone JK, Zanella VG, Martins MD, Engler AJ, Lamers ML. PMID: 30559248.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    15. Fifteen years of Servitude et Grandeur to the application of a biophysical technique in medicine: The tale of AFMBioMed. J Mol Recognit. 2019 03; 32(3):e2773. Pellequer JL, Parot P, Navajas D, Kumar S, Svetlicic V, Scheuring S, Hu J, Li B, Engler A, Sousa S, Lekka M, Szymonski M, Schillers H, Odorico M, Lafont F, Janel S, Rico F. PMID: 30565321.
      View in: PubMed   Mentions:    Fields:    
    16. Unveiling the Role of the Most Impactful Cardiovascular Risk Locus through Haplotype Editing. Cell. 2018 12 13; 175(7):1796-1810.e20. Lo Sardo V, Chubukov P, Ferguson W, Kumar A, Teng EL, Duran M, Zhang L, Cost G, Engler AJ, Urnov F, Topol EJ, Torkamani A, Baldwin KK. PMID: 30528432.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    17. Macro- and microplastics affect cold-water corals growth, feeding and behaviour. Sci Rep. 2018 10 17; 8(1):15299. Chapron L, Peru E, Engler A, Ghiglione JF, Meistertzheim AL, Pruski AM, Purser A, Vétion G, Galand PE, Lartaud F. PMID: 30333567.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsPHPublic Health
    18. Rationally engineered advances in cancer research. APL Bioeng. 2018 Sep; 2(3):031601. Engler AJ, Discher DE. PMID: 31069310.
      View in: PubMed   Mentions:
    19. Biomaterials to model and measure epithelial cancers. Nat Rev Mater. 2018 Nov; 3(11):418-430. Beri P, Matte BF, Fattet L, Kim D, Yang J, Engler AJ. PMID: 30416759.
      View in: PubMed   Mentions:
    20. RAP2 mediates mechanoresponses of the Hippo pathway. Nature. 2018 08; 560(7720):655-660. Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, Moroishi T, Luo M, Plouffe SW, Diao Y, Ye Z, Park HW, Wang X, Yu FX, Chien S, Wang CY, Ren B, Engler AJ, Guan KL. PMID: 30135582.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    21. Preserved cardiac function by vinculin enhances glucose oxidation and extends health- and life-span. APL Bioeng. 2018 Sep; 2(3). Sessions AO, Min P, Cordes T, Weickert BJ, Divakaruni AS, Murphy AN, Metallo CM, Engler AJ. PMID: 30105314.
      View in: PubMed   Mentions:
    22. Extracellular matrix in lung development, homeostasis and disease. Matrix Biol. 2018 11; 73:77-104. Zhou Y, Horowitz JC, Naba A, Ambalavanan N, Atabai K, Balestrini J, Bitterman PB, Corley RA, Ding BS, Engler AJ, Hansen KC, Hagood JS, Kheradmand F, Lin QS, Neptune E, Niklason L, Ortiz LA, Parks WC, Tschumperlin DJ, White ES, Chapman HA, Thannickal VJ. PMID: 29524630.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    23. Heterogeneous muscle gene expression patterns in patients with massive rotator cuff tears. PLoS One. 2018; 13(1):e0190439. Gibbons MC, Fisch KM, Pichika R, Cheng T, Engler AJ, Schenk S, Lane JG, Singh A, Ward SR. PMID: 29293645.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    24. Recent Advances in Extrusion-Based 3D Printing for Biomedical Applications. Adv Healthc Mater. 2018 04; 7(8):e1701161. Placone JK, Engler AJ. PMID: 29283220.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    25. Understanding the extracellular forces that determine cell fate and maintenance. Development. 2017 12 01; 144(23):4261-4270. Kumar A, Placone JK, Engler AJ. PMID: 29183939.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    26. The role of mechanobiology in progression of rotator cuff muscle atrophy and degeneration. J Orthop Res. 2018 02; 36(2):546-556. Gibbons MC, Singh A, Engler AJ, Ward SR. PMID: 28755470.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    27. The provisional matrix: setting the stage for tissue repair outcomes. Matrix Biol. 2017 07; 60-61:1-4. Barker TH, Engler AJ. PMID: 28527902.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    28. Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels. Proc Natl Acad Sci U S A. 2017 05 30; 114(22):5647-5652. Hadden WJ, Young JL, Holle AW, McFetridge ML, Kim DY, Wijesinghe P, Taylor-Weiner H, Wen JH, Lee AR, Bieback K, Vo BN, Sampson DD, Kennedy BF, Spatz JP, Engler AJ, Choi YS. PMID: 28507138.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    29. Mechanically patterned neuromuscular junctions-in-a-dish have improved functional maturation. Mol Biol Cell. 2017 Jul 07; 28(14):1950-1958. Happe CL, Tenerelli KP, Gromova AK, Kolb F, Engler AJ. PMID: 28495800.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    30. Mechanical regulation of cardiac fibroblast profibrotic phenotypes. Mol Biol Cell. 2017 Jul 07; 28(14):1871-1882. Herum KM, Choppe J, Kumar A, Engler AJ, McCulloch AD. PMID: 28468977.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    31. Metastatic State of Cancer Cells May Be Indicated by Adhesion Strength. Biophys J. 2017 Feb 28; 112(4):736-745. Fuhrmann A, Banisadr A, Beri P, Tlsty TD, Engler AJ. PMID: 28256233.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    32. Modest overexpression of FOXO maintains cardiac proteostasis and ameliorates age-associated functional decline. Aging Cell. 2017 Feb; 16(1):93-103. Blice-Baum AC, Zambon AC, Kaushik G, Viswanathan MC, Engler AJ, Bodmer R, Cammarato A. PMID: 28090761.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    33. Histological Evidence of Muscle Degeneration in Advanced Human Rotator Cuff Disease. J Bone Joint Surg Am. 2017 Feb 01; 99(3):190-199. Gibbons MC, Singh A, Anakwenze O, Cheng T, Pomerantz M, Schenk S, Engler AJ, Ward SR. PMID: 28145949.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    34. Extracellular matrix downregulation in the Drosophila heart preserves contractile function and improves lifespan. Matrix Biol. 2017 10; 62:15-27. Sessions AO, Kaushik G, Parker S, Raedschelders K, Bodmer R, Van Eyk JE, Engler AJ. PMID: 27793636.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    35. Rotator cuff tear state modulates self-renewal and differentiation capacity of human skeletal muscle progenitor cells. J Orthop Res. 2017 08; 35(8):1816-1823. Thomas KA, Gibbons MC, Lane JG, Singh A, Ward SR, Engler AJ. PMID: 27699827.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    36. High content image analysis of focal adhesion-dependent mechanosensitive stem cell differentiation. Integr Biol (Camb). 2016 10 10; 8(10):1049-1058. Holle AW, McIntyre AJ, Kehe J, Wijesekara P, Young JL, Vincent LG, Engler AJ. PMID: 27723854.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    37. Sixth International AFM BioMed Conference on AFM in life sciences and medicine, December 13 to 17, 2014, San Diego, California. J Mol Recognit. 2016 09; 29(9):404-5. Engler AJ, Parot P, Pellequer JL. PMID: 27502838.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    38. Mechanical Regulation of Cardiac Aging in Model Systems. Circ Res. 2016 05 13; 118(10):1553-62. Sessions AO, Engler AJ. PMID: 27174949.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    39. Muscle architectural changes after massive human rotator cuff tear. J Orthop Res. 2016 12; 34(12):2089-2095. Gibbons MC, Sato EJ, Bachasson D, Cheng T, Azimi H, Schenk S, Engler AJ, Singh A, Ward SR. PMID: 27061583.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    40. Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction. Proc Natl Acad Sci U S A. 2016 Mar 22; 113(12):3185-90. Zhang ZN, Freitas BC, Qian H, Lux J, Acab A, Trujillo CA, Herai RH, Nguyen Huu VA, Wen JH, Joshi-Barr S, Karpiak JV, Engler AJ, Fu XD, Muotri AR, Almutairi A. PMID: 26944080.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    41. Mechanical Characterization of a Dynamic and Tunable Methacrylated Hyaluronic Acid Hydrogel. J Biomech Eng. 2016 Feb; 138(2):021003. Ondeck MG, Engler AJ. PMID: 26746491.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    42. Mechanical Forces Reshape Differentiation Cues That Guide Cardiomyogenesis. Circ Res. 2016 Jan 22; 118(2):296-310. Happe CL, Engler AJ. PMID: 26838315.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    43. The cytoskeleton regulates cell attachment strength. Biophys J. 2015 Jul 07; 109(1):57-65. Fuhrmann A, Engler AJ. PMID: 26153702.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    44. Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised ß-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy. Cell Stem Cell. 2015 Jul 02; 17(1):89-100. Wu H, Lee J, Vincent LG, Wang Q, Gu M, Lan F, Churko JM, Sallam KI, Matsa E, Sharma A, Gold JD, Engler AJ, Xiang YK, Bers DM, Wu JC. PMID: 26095046.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    45. Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart. Sci Transl Med. 2015 Jun 17; 7(292):292ra99. Kaushik G, Spenlehauer A, Sessions AO, Trujillo AS, Fuhrmann A, Fu Z, Venkatraman V, Pohl D, Tuler J, Wang M, Lakatta EG, Ocorr K, Bodmer R, Bernstein SI, Van Eyk JE, Cammarato A, Engler AJ. PMID: 26084806.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    46. Haptotaxis is cell type specific and limited by substrate adhesiveness. Cell Mol Bioeng. 2015 Dec 01; 8(4):530-542. Wen JH, Choi O, Taylor-Weiner H, Fuhrmann A, Karpiak JV, Almutairi A, Engler AJ. PMID: 26640598.
      View in: PubMed   Mentions:
    47. Epimuscular Fat in the Human Rotator Cuff Is a Novel Beige Depot. Stem Cells Transl Med. 2015 Jul; 4(7):764-74. Meyer GA, Gibbons MC, Sato E, Lane JG, Ward SR, Engler AJ. PMID: 25999520.
      View in: PubMed   Mentions: 6     Fields:    
    48. Traction forces mediated by integrin signaling are necessary for definitive endoderm specification. J Cell Sci. 2015 May 15; 128(10):1961-8. Taylor-Weiner H, Ravi N, Engler AJ. PMID: 25908864.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    49. Nonlinear 3D projection printing of concave hydrogel microstructures for long-term multicellular spheroid and embryoid body culture. Lab Chip. 2015 Jun 07; 15(11):2412-8. Hribar KC, Finlay D, Ma X, Qu X, Ondeck MG, Chung PH, Zanella F, Engler AJ, Sheikh F, Vuori K, Chen SC. PMID: 25900329.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    50. Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway. Nat Cell Biol. 2015 May; 17(5):678-88. Wei SC, Fattet L, Tsai JH, Guo Y, Pai VH, Majeski HE, Chen AC, Sah RL, Taylor SS, Engler AJ, Yang J. PMID: 25893917.
      View in: PubMed   Mentions: 172     Fields:    Translation:HumansAnimalsCells
    51. Transfer stamping of human mesenchymal stem cell patches using thermally expandable hydrogels with tunable cell-adhesive properties. Biomaterials. 2015 Jun; 54:44-54. Jun I, Lee YB, Choi YS, Engler AJ, Park H, Shin H. PMID: 25907038.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    52. 3D surface topology guides stem cell adhesion and differentiation. Biomaterials. 2015 Jun; 52:140-7. Viswanathan P, Ondeck MG, Chirasatitsin S, Ngamkham K, Reilly GC, Engler AJ, Battaglia G. PMID: 25818420.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    53. Acute shear stress direction dictates adherent cell remodeling and verifies shear profile of spinning disk assays. Phys Biol. 2015 Jan 26; 12(1):016011. Fuhrmann A, Engler AJ. PMID: 25619322.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    54. Muscle progenitor cell regenerative capacity in the torn rotator cuff. J Orthop Res. 2015 Mar; 33(3):421-9. Meyer GA, Farris AL, Sato E, Gibbons M, Lane JG, Ward SR, Engler AJ. PMID: 25410765.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    55. Mechanosensitive kinases regulate stiffness-induced cardiomyocyte maturation. Sci Rep. 2014 Sep 19; 4:6425. Young JL, Kretchmer K, Ondeck MG, Zambon AC, Engler AJ. PMID: 25236849.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    56. Digital Plasmonic Patterning for Localized Tuning of Hydrogel Stiffness. Adv Funct Mater. 2014 Aug 20; 24(31):4922-4926. Hribar KC, Choi YS, Ondeck M, Engler AJ, Chen S. PMID: 26120293.
      View in: PubMed   Mentions:
    57. Extracellular matrix regulation in the muscle satellite cell niche. Connect Tissue Res. 2015 Feb; 56(1):1-8. Thomas K, Engler AJ, Meyer GA. PMID: 25047058.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    58. Interplay of matrix stiffness and protein tethering in stem cell differentiation. Nat Mater. 2014 Oct; 13(10):979-87. Wen JH, Vincent LG, Fuhrmann A, Choi YS, Hribar KC, Taylor-Weiner H, Chen S, Engler AJ. PMID: 25108614.
      View in: PubMed   Mentions: 179     Fields:    Translation:HumansCells
    59. Cation type specific cell remodeling regulates attachment strength. PLoS One. 2014; 9(7):e102424. Fuhrmann A, Li J, Chien S, Engler AJ. PMID: 25014042.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    60. Materials as stem cell regulators. Nat Mater. 2014 Jun; 13(6):547-57. Murphy WL, McDevitt TC, Engler AJ. PMID: 24845994.
      View in: PubMed   Mentions: 155     Fields:    Translation:HumansAnimalsCells
    61. A dual role for integrin-linked kinase and ß1-integrin in modulating cardiac aging. Aging Cell. 2014 Jun; 13(3):431-40. Nishimura M, Kumsta C, Kaushik G, Diop SB, Ding Y, Bisharat-Kernizan J, Catan H, Cammarato A, Ross RS, Engler AJ, Bodmer R, Hansen M, Ocorr K. PMID: 24400780.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    62. From stem cells to cardiomyocytes: the role of forces in cardiac maturation, aging, and disease. Prog Mol Biol Transl Sci. 2014; 126:219-42. Kaushik G, Engler AJ. PMID: 25081620.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    63. Mechanotransduction. Preface. Prog Mol Biol Transl Sci. 2014; 126:xiii-xiv. Engler AJ, Kumar S. PMID: 25081625.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    64. A Drosophila melanogaster model of diastolic dysfunction and cardiomyopathy based on impaired troponin-T function. Circ Res. 2014 Jan 17; 114(2):e6-17. Viswanathan MC, Kaushik G, Engler AJ, Lehman W, Cammarato A. PMID: 24221941.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    65. In situ mechanotransduction via vinculin regulates stem cell differentiation. Stem Cells. 2013 Nov; 31(11):2467-77. Holle AW, Tang X, Vijayraghavan D, Vincent LG, Fuhrmann A, Choi YS, del Álamo JC, Engler AJ. PMID: 23897765.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    66. Defined extracellular matrix components are necessary for definitive endoderm induction. Stem Cells. 2013 Oct; 31(10):2084-94. Taylor-Weiner H, Schwarzbauer JE, Engler AJ. PMID: 23766144.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    67. A co-culture device with a tunable stiffness to understand combinatorial cell-cell and cell-matrix interactions. Integr Biol (Camb). 2013 Nov; 5(11):1344-54. Rao N, Grover GN, Vincent LG, Evans SC, Choi YS, Spencer KH, Hui EE, Engler AJ, Christman KL. PMID: 24061208.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    68. Stimulation of adipogenesis of adult adipose-derived stem cells using substrates that mimic the stiffness of adipose tissue. Biomaterials. 2013 Nov; 34(34):8581-8. Young DA, Choi YS, Engler AJ, Christman KL. PMID: 23953825.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    69. Stem cell differentiation: Post-degradation forces kick in. Nat Mater. 2013 May; 12(5):384-6. Vincent LG, Engler AJ. PMID: 23603879.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    70. In vivo response to dynamic hyaluronic acid hydrogels. Acta Biomater. 2013 Jul; 9(7):7151-7. Young JL, Tuler J, Braden R, Schüp-Magoffin P, Schaefer J, Kretchmer K, Christman KL, Engler AJ. PMID: 23523533.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    71. Mesenchymal stem cell durotaxis depends on substrate stiffness gradient strength. Biotechnol J. 2013 Apr; 8(4):472-84. Vincent LG, Choi YS, Alonso-Latorre B, del Álamo JC, Engler AJ. PMID: 23390141.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    72. Density gradient multilayered polymerization (DGMP): a novel technique for creating multi-compartment, customizable scaffolds for tissue engineering. J Vis Exp. 2013 Feb 12; (72). Joshi-Barr S, Karpiak JV, Ner Y, Wen JH, Engler AJ, Almutairi A. PMID: 23426045.
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    73. Dynamic and reversible surface topography influences cell morphology. J Biomed Mater Res A. 2013 Aug; 101(8):2313-21. Kiang JD, Wen JH, del Álamo JC, Engler AJ. PMID: 23355509.
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    74. Cell instructive microporous scaffolds through interface engineering. J Am Chem Soc. 2012 Dec 12; 134(49):20103-9. Viswanathan P, Chirasatitsin S, Ngamkham K, Engler AJ, Battaglia G. PMID: 23163574.
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    75. Control of stem cell fate and function by engineering physical microenvironments. Integr Biol (Camb). 2012 Sep; 4(9):1008-18. Park J, Kim P, Helen W, Engler AJ, Levchenko A, Kim DH. PMID: 23077731.
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    76. Measuring passive myocardial stiffness in Drosophila melanogaster to investigate diastolic dysfunction. J Cell Mol Med. 2012 Aug; 16(8):1656-62. Kaushik G, Zambon AC, Fuhrmann A, Bernstein SI, Bodmer R, Engler AJ, Cammarato A. PMID: 22225769.
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    77. The alignment and fusion assembly of adipose-derived stem cells on mechanically patterned matrices. Biomaterials. 2012 Oct; 33(29):6943-51. Choi YS, Vincent LG, Lee AR, Kretchmer KC, Chirasatitsin S, Dobke MK, Engler AJ. PMID: 22800539.
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    78. Mechanical derivation of functional myotubes from adipose-derived stem cells. Biomaterials. 2012 Mar; 33(8):2482-91. Choi YS, Vincent LG, Lee AR, Dobke MK, Engler AJ. PMID: 22197570.
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    79. In situ mechanical analysis of myofibrillar perturbation and aging on soft, bilayered Drosophila myocardium. Biophys J. 2011 Dec 07; 101(11):2629-37. Kaushik G, Fuhrmann A, Cammarato A, Engler AJ. PMID: 22261050.
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    80. Wet nanoscale imaging and testing of polymersomes. Small. 2011 Jul 18; 7(14):2010-5. Battaglia G, LoPresti C, Massignani M, Warren NJ, Madsen J, Forster S, Vasilev C, Hobbs JK, Armes SP, Chirasatitsin S, Engler AJ. PMID: 21695783.
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    81. More than a feeling: discovering, understanding, and influencing mechanosensing pathways. Curr Opin Biotechnol. 2011 Oct; 22(5):648-54. Holle AW, Engler AJ. PMID: 21536426.
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    82. Controlling polymersome surface topology at the nanoscale by membrane confined polymer/polymer phase separation. ACS Nano. 2011 Mar 22; 5(3):1775-84. LoPresti C, Massignani M, Fernyhough C, Blanazs A, Ryan AJ, Madsen J, Warren NJ, Armes SP, Lewis AL, Chirasatitsin S, Engler AJ, Battaglia G. PMID: 21344879.
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    83. Stiffness gradients mimicking in vivo tissue variation regulate mesenchymal stem cell fate. PLoS One. 2011 Jan 05; 6(1):e15978. Tse JR, Engler AJ. PMID: 21246050.
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    84. Hydrogels with time-dependent material properties enhance cardiomyocyte differentiation in vitro. Biomaterials. 2011 Feb; 32(4):1002-9. Young JL, Engler AJ. PMID: 21071078.
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    85. Preparation of hydrogel substrates with tunable mechanical properties. Curr Protoc Cell Biol. 2010 Jun; Chapter 10:Unit 10.16. Tse JR, Engler AJ. PMID: 20521229.
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    86. Detecting cell-adhesive sites in extracellular matrix using force spectroscopy mapping. J Phys Condens Matter. 2010 May 19; 22(19):194102. Chirasatitsin S, Engler AJ. PMID: 21152375.
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    87. Nanoscopic mechanical anisotropy in hydrogel surfaces. Soft Matter. 2010 Jan 01; 6(18):4466-4470. Flores-Merino MV, Chirasatitsin S, Lopresti C, Reilly GC, Battaglia G, Engler AJ. PMID: 20953281.
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    88. Cell rheology: Stressed-out stem cells. Nat Mater. 2010 Jan; 9(1):4-6. Holle AW, Engler AJ. PMID: 20019660.
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    89. Innovations in cell mechanobiology. J Biomech. 2010 Jan 05; 43(1):1. David Merryman W, Engler AJ. PMID: 19815212.
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    90. Intrinsic extracellular matrix properties regulate stem cell differentiation. J Biomech. 2010 Jan 05; 43(1):55-62. Reilly GC, Engler AJ. PMID: 19800626.
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    91. A novel mode of cell detachment from fibrillar fibronectin matrix under shear. J Cell Sci. 2009 May 15; 122(Pt 10):1647-53. Engler AJ, Chan M, Boettiger D, Schwarzbauer JE. PMID: 19401337.
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    92. Multiscale modeling of form and function. Science. 2009 Apr 10; 324(5924):208-12. Engler AJ, Humbert PO, Wehrle-Haller B, Weaver VM. PMID: 19359578.
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    93. Matrix strains induced by cells: Computing how far cells can feel. Cell Mol Bioeng. 2009 Mar 01; 2(1):39-48. Sen S, Engler AJ, Discher DE. PMID: 20582230.
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    94. Stem cell fate dictated solely by altered nanotube dimension. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2130-5. Oh S, Brammer KS, Li YS, Teng D, Engler AJ, Chien S, Jin S. PMID: 19179282.
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    95. Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating. J Cell Sci. 2008 Nov 15; 121(Pt 22):3794-802. Engler AJ, Carag-Krieger C, Johnson CP, Raab M, Tang HY, Speicher DW, Sanger JW, Sanger JM, Discher DE. PMID: 18957515.
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    96. Fibronectin expression modulates mammary epithelial cell proliferation during acinar differentiation. Cancer Res. 2008 May 01; 68(9):3185-92. Williams CM, Engler AJ, Slone RD, Galante LL, Schwarzbauer JE. PMID: 18451144.
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    97. Extracellular matrix elasticity directs stem cell differentiation. J Musculoskelet Neuronal Interact. 2007 Oct-Dec; 7(4):335. Engler AJ, Sweeney HL, Discher DE, Schwarzbauer JE. PMID: 18094500.
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    98. Cell responses to the mechanochemical microenvironment--implications for regenerative medicine and drug delivery. Adv Drug Deliv Rev. 2007 Nov 10; 59(13):1329-39. Rehfeldt F, Engler AJ, Eckhardt A, Ahmed F, Discher DE. PMID: 17900747.
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    99. Microscopic methods for measuring the elasticity of gel substrates for cell culture: microspheres, microindenters, and atomic force microscopy. Methods Cell Biol. 2007; 83:47-65. Frey MT, Engler A, Discher DE, Lee J, Wang YL. PMID: 17613304.
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    100. Microtissue elasticity: measurements by atomic force microscopy and its influence on cell differentiation. Methods Cell Biol. 2007; 83:521-45. Engler AJ, Rehfeldt F, Sen S, Discher DE. PMID: 17613323.
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    101. Matrix elasticity directs stem cell lineage specification. Cell. 2006 Aug 25; 126(4):677-89. Engler AJ, Sen S, Sweeney HL, Discher DE. PMID: 16923388.
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    102. A hemoglobin fragment found in cervicovaginal fluid from women in labor potentiates the action of agents that promote contraction of smooth muscle cells. Peptides. 2006 Jul; 27(7):1794-800. Brown AG, Leite RS, Engler AJ, Discher DE, Strauss JF. PMID: 16621150.
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    103. Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance. . 2006 Jun; 290(6):H2196-203. Berry MF, Engler AJ, Woo YJ, Pirolli TJ, Bish LT, Jayasankar V, Morine KJ, Gardner TJ, Discher DE, Sweeney HL. PMID: 16473959.
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    104. Power-law rheology of isolated nuclei with deformation mapping of nuclear substructures. Biophys J. 2005 Oct; 89(4):2855-64. Dahl KN, Engler AJ, Pajerowski JD, Discher DE. PMID: 16055543.
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    105. Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments. J Cell Biol. 2004 Sep 13; 166(6):877-87. Engler AJ, Griffin MA, Sen S, Bönnemann CG, Sweeney HL, Discher DE. PMID: 15364962.
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    106. Targeted worm micelles. Biomacromolecules. 2004 Sep-Oct; 5(5):1714-9. Dalhaimer P, Engler AJ, Parthasarathy R, Discher DE. PMID: 15360279.
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    107. Elasticity of native and cross-linked polyelectrolyte multilayer films. Biomacromolecules. 2004 Sep-Oct; 5(5):1908-16. Richert L, Engler AJ, Discher DE, Picart C. PMID: 15360305.
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    108. Patterning, prestress, and peeling dynamics of myocytes. Biophys J. 2004 Feb; 86(2):1209-22. Griffin MA, Engler AJ, Barber TA, Healy KE, Sweeney HL, Discher DE. PMID: 14747355.
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    109. Substrate compliance versus ligand density in cell on gel responses. Biophys J. 2004 Jan; 86(1 Pt 1):617-28. Engler A, Bacakova L, Newman C, Hategan A, Griffin M, Discher D. PMID: 14695306.
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    110. Solution structure of human immunodeficiency virus type 1 Vpr(13-33) peptide in micelles. Eur J Biochem. 2001 Jan; 268(2):389-95. Engler A, Stangler T, Willbold D. PMID: 11168374.
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