Mariko Horii

Title(s)Assistant Adjunct Professor, Pathology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-4996-6792 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Kagawa University School of Medicine, JapanMD03/2007Medicine
    St. Luke's International Hospital, JapanJunior Residency03/2009Clinical Medicine
    St. Luke’s International Hospital, JapanSenior Residency03/2013Obstetrics and Gynecology
    University of California San Diego, San DiegoPostdoctoral training01/2019Placental biology and reproductive medicine

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Stem Cell-based Modeling of Placental Defects associated with Early-Onset Preeclampsia
    NIH R01HD114720Jul 1, 2024 - Apr 30, 2029
    Role: Principal Investigator
    Modeling Preeclampsia Using Human Pluripotent Stem Cells
    NIH R00HD091452Jun 1, 2020 - May 31, 2023
    Role: Principal Investigator
    Modeling Preeclampsia Using Human Pluripotent Stem Cells
    NIH K99HD091452Jun 15, 2018 - May 31, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Correction: Current Strategies of Modeling Human Trophoblast Using Human Pluripotent Stem Cells in vitro. Curr Protoc. 2024 Apr; 4(4):e1049. Cheung VC, Bui T, Soncin F, Bai T, Kessler JA, Parast MM, Horii M. PMID: 38648076.
      View in: PubMed   Mentions:    Fields:    
    2. iPSC-based modeling of preeclampsia identifies epigenetic defects in extravillous trophoblast differentiation. iScience. 2024 Apr 19; 27(4):109569. Morey R, Bui T, Cheung VC, Dong C, Zemke JE, Requena D, Arora H, Jackson MG, Pizzo D, Theunissen TW, Horii M. PMID: 38623329; PMCID: PMC11016801.
      View in: PubMed   Mentions:
    3. Discovery and verification of extracellular microRNA biomarkers for diagnostic and prognostic assessment of preeclampsia at triage. Sci Adv. 2023 Dec 22; 9(51):eadg7545. Morey R, Poling L, Srinivasan S, Martinez-King C, Anyikam A, Zhang-Rutledge K, To C, Hakim A, Mochizuki M, Verma K, Mason A, Tran V, Meads M, Lamale-Smith L, Roeder H, Horii M, Ramos GA, DeHoff P, Parast MM, Pantham P, Laurent LC. PMID: 38117879; PMCID: PMC10732528.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. High placental expression of FLT1, LEP, PHYHIP and IL3RA - In persons of African ancestry with severe preeclampsia. Placenta. 2023 Dec; 144:13-22. Aisagbonhi O, Bui T, Nasamran CA, St Louis H, Pizzo D, Meads M, Mulholland M, Magallanes C, Lamale-Smith L, Laurent LC, Morey R, Jacobs MB, Fisch KM, Horii M. PMID: 37949031; PMCID: PMC10843761.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Current Strategies of Modeling Human Trophoblast Using Human Pluripotent Stem Cells in vitro. Curr Protoc. 2023 Oct; 3(10):e875. Cheung VC, Bui T, Soncin F, Bai T, Kessler JA, Parast MM, Horii M. PMID: 37787612; PMCID: PMC10558083.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Histopathologic and Transcriptomic Profiling Identifies Novel Trophoblast Defects in Patients With Preeclampsia and Maternal Vascular Malperfusion. Mod Pathol. 2023 02; 36(2):100035. Horii M, To C, Morey R, Jacobs MB, Li Y, Nelson KK, Meads M, Siegel BA, Pizzo D, Adami R, Zhang-Rutledge K, Lamale-Smith L, Laurent LC, Parast MM. PMID: 36853788; PMCID: PMC10081686.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    7. Modeling placental development and disease using human pluripotent stem cells. Placenta. 2023 09 26; 141:18-25. Morey R, Bui T, Fisch KM, Horii M. PMID: 36333266; PMCID: PMC10148925.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    8. Derivation of functional trophoblast stem cells from primed human pluripotent stem cells. Stem Cell Reports. 2022 06 14; 17(6):1303-1317. Soncin F, Morey R, Bui T, Requena DF, Cheung VC, Kallol S, Kittle R, Jackson MG, Farah O, Chousal J, Meads M, Pizzo D, Horii M, Fisch KM, Parast MM. PMID: 35594858; PMCID: PMC9214048.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    9. Modeling preeclampsia using human induced pluripotent stem cells. Sci Rep. 2021 03 15; 11(1):5877. Horii M, Morey R, Bui T, Touma O, Nelson KK, Cho HY, Rishik H, Laurent LC, Parast MM. PMID: 33723311; PMCID: PMC7961010.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    10. High altitude regulates the expression of AMPK pathways in human placenta. Placenta. 2021 01 15; 104:267-276. Lorca RA, Houck JA, Laurent LC, Matarazzo CJ, Baker K, Horii M, Nelson KK, Bales ES, Euser AG, Parast MM, Moore LG, Julian CG. PMID: 33472134.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    11. Modeling human trophoblast, the placental epithelium at the maternal fetal interface. Reproduction. 2020 07; 160(1):R1-R11. Horii M, Touma O, Bui T, Parast MM. PMID: 32485667; PMCID: PMC7286067.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    12. An Improved Two-Step Protocol for Trophoblast Differentiation of Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol. 2019 09; 50(1):e96. Horii M, Bui T, Touma O, Cho HY, Parast MM. PMID: 31479595; PMCID: PMC6730560.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    13. Hypoxia Directs Human Extravillous Trophoblast Differentiation in a Hypoxia-Inducible Factor-Dependent Manner. Am J Pathol. 2017 Apr; 187(4):767-780. Wakeland AK, Soncin F, Moretto-Zita M, Chang CW, Horii M, Pizzo D, Nelson KK, Laurent LC, Parast MM. PMID: 28167044; PMCID: PMC5397702.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    14. Human pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):E3882-91. Horii M, Li Y, Wakeland AK, Pizzo DP, Nelson KK, Sabatini K, Laurent LC, Liu Y, Parast MM. PMID: 27325764; PMCID: PMC4941448.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    15. MTA3 regulates differentiation of human cytotrophoblast stem cells. Placenta. 2015 Sep; 36(9):974-80. Horii M, Moretto-Zita M, Nelson KK, Li Y, Parast MM. PMID: 26198267; PMCID: PMC4554833.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    16. Hepatoblastoma in an infant with paternal uniparental disomy 14. Congenit Anom (Kyoto). 2012 Dec; 52(4):219-20. Horii M, Horiuchi H, Momoeda M, Nakagawa M, Hirata M, Kusakawa I, Yamanaka M. PMID: 23181499.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    17. Nitric oxide prevents phosphorylation of neuronal nitric oxide synthase at serine1412 by inhibiting the Akt/PKB and CaM-K II signaling pathways. Int J Mol Med. 2012 Jul; 30(1):15-20. Song T, Hatano N, Sugimoto K, Horii M, Yamaguchi F, Tokuda M, Miyamoto Y, Kambe T, Watanabe Y. PMID: 22576624.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    18. Rare sugar D-allose enhances anti-tumor effect of 5-fluorouracil on the human hepatocellular carcinoma cell line HuH-7. J Biosci Bioeng. 2008 Sep; 106(3):248-52. Yamaguchi F, Kamitori K, Sanada K, Horii M, Dong Y, Sui L, Tokuda M. PMID: 18930000.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    19. Calcium/calmodulin-dependent protein kinase I inhibits neuronal nitric-oxide synthase activity through serine 741 phosphorylation. FEBS Lett. 2004 Jul 16; 570(1-3):133-7. Song T, Hatano N, Horii M, Tokumitsu H, Yamaguchi F, Tokuda M, Watanabe Y. PMID: 15251453.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    20. Post-synaptic density-95 promotes calcium/calmodulin-dependent protein kinase II-mediated Ser847 phosphorylation of neuronal nitric oxide synthase. Biochem J. 2003 Jun 01; 372(Pt 2):465-71. Watanabe Y, Song T, Sugimoto K, Horii M, Araki N, Tokumitsu H, Tezuka T, Yamamoto T, Tokuda M. PMID: 12630910; PMCID: PMC1223425.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    21. Histological findings of bone marrow edema pattern on MRI in osteonecrosis of the femoral head. J Orthop Sci. 2000; 5(5):520-3. Kubo T, Yamamoto T, Inoue S, Horii M, Ueshima K, Iwamoto Y, Hirasawa Y. PMID: 11180912.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    22. Contrasting effects of water-soluble and water-insoluble dietary fibers on bile acid conjugation and taurine metabolism in the rat. Lipids. 1990 Jun; 25(6):335-40. Ide T, Horii M, Yamamoto T, Kawashima K. PMID: 2164126.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    23. Bile acid conjugation and hepatic taurine concentration in rats fed on pectin. Br J Nutr. 1989 Nov; 62(3):539-50. Ide T, Horii M, Kawashima K, Yamamoto T. PMID: 2605154.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    24. [A case of post-radiation constrictive pericarditis developing 17 years after radiation therapy]. Nihon Naika Gakkai Zasshi. 1988 Jun; 77(6):834-8. Takasaki I, Horii M, Otsuka K, Tsukiyama H, Arita T, Okatsu M, Sugimoto K, Sano T, Kobayashi K, Hakuta T. PMID: 3225502.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
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