Nicholas Webster

Title(s)Professor In Residence, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-3827-5750 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Cambridge, Cambridge, UKBA, MA06/1981Natural Sciences
    Stanford University, Stanford, CAPhD08/1986Chemistry
    CNRS, Strasbourg, FrancePost-doc12/1988Molecular Biology
    Collapse Awards and Honors
    Cambridge University1978  - 1981Wilson Scholarship in Natural Sciences
    The Royal Society, London1986  - 1988European Exchange Fellowship
    Western Society for Clinical Investigation1996  - 1996Young Faculty Award
    Institute for the Study of Aging2006  - 2006Innovative Research Award
    Department of Veterans Affairs1993  - 2013Research Career Scientist Award
    Department of Veterans Affairs2013  - presSenior Research Career Scientist Award

    Collapse Overview 
    Collapse Overview
    Dr. Webster's research lies in the general area of Endocrinology, Neuroendocrinology and Metabolism and addresses the mechanisms of intracellular signaling in response to hormonal and metabolic stimuli. He has a long-standing interest in the insulin receptor and its downstream signaling. His lab has shown how a single insulin receptor gene gives rise to two distinct insulin receptors and how these receptors differ in regulating physiological processes. He identified the splicing factors responsible for alternative splicing of the gene that gives rise to the two receptor isoforms. His lab created hepatocyte-specific knockouts of SRSF3 and SRSF1 and found that loss of SRSF3, but not SRSF1, disrupted hepatic architecture, impaired hepatocyte maturation, altered glucose and lipid homeostasis and eventually led to hepatocellular carcinoma (HCC) as mice age. Tumor development is preceded by chronic liver disease with progressive non-alcoholic fatty liver disease (NAFLD), then non-alcoholic steatohepatitis (NASH) and fibrosis. They showed that SRSF3 protein expression was decreased in human liver samples with NAFLD, NASH or cirrhosis and ultimately in non-viral HCC. Subsequently, they showed that lipid excess caused proteosomal degradation of SRSF3 through a novel NEDD8-mediated pathway. Excitingly, prevention of SRSF3 degradation in vivo protected mice from hepatic steatosis, fibrosis and inflammation suggesting that loss of SRSF3 may be an initiating event in progressive liver disease. The lab is currently investigating the pathway for SRSF3 degradation in fatty liver disease and identifying the role for E3-ligases in post-translational regulation of SRSF3.
    A second project is focused on the link between time-restricted feeding, obesity and cancer. Obesity is a risk factor for many cancers and the evidence for the obesity-breast cancer connection is particularly strong in post-menopausal women although the mechanisms remain poorly understood. His lab confirmed that HFD-induced or genetic obesity enhances tumor growth using orthotopic injection of syngeneic breast cancer cells. They showed that time-restricted feeding (TRF), a form of intermittent fasting in which food intake is limited to a particular number of hours per day, causes a dramatic reduction in hepatic steatosis and metabolic parameters and inhibits breast cancer growth. Mechanistically, they showed that the reduction in circulating insulin levels was the origin of the beneficial effect of TRF on tumor growth. Recent experiments have shown that TRF is equally effective against NASH-driven liver cancer.
    In a third collaborative project with Dr. Eyal Raz's lab, he has uncovered a new pathway in CD11c+ dendritic cells (DC) that controls T helper cell differentiation into the Th17 and Th2 lineages. Deletion of Gnas in CD11c+ cell (Gnas/CD11c) causes the development of spontaneous airway inflammation that mimics the pathology of eosinophilic Th2-biased asthmatic patients. They showed that cAMP-PKA-CREB signaling regulates conventional type-2 Dendritic Cells (cDC2s), but not cDC1s, and reprograms their Th17-inducing properties via repression of the IRF4 and KLF4 transcription factors. Interestingly, these KO mice are resistant to diet-induced obesity. The mice do not develop hepatic steatosis, are insulin sensitive, consume more oxygen, and have slightly higher body temperature despite having the same food intake. They have shown that this is due to CD11c+ dendritic cells not macrophages, and the DCs reprogram white adipose tissue, causing beigeing and increased mitochondrial uncoupling.
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    BLR&D Research Career Scientist Award Application
    NIH IK6BX005224Apr 1, 2020 - Mar 31, 2027
    Role: Principal Investigator
    SRSF3 degradation in liver disease and hepatocellular carcinoma
    NIH I01BX004848Apr 1, 2020 - Mar 31, 2024
    Role: Principal Investigator
    A novel pathway of Th17/Th2 induction: The role of cAMP signaling in DC
    NIH R01HL141999Jan 1, 2019 - Dec 31, 2022
    Role: Co-Principal Investigator
    Control of mucosal immunity by Gas- vs Gai-linked GPCR signaling in dendritic cells
    NIH U01AI125860Jun 6, 2016 - May 31, 2021
    Role: Co-Investigator
    Center for Reproductive Science and Medicine
    NIH/NICHD P50HD012303Jun 1, 2016 - May 31, 2021
    Role: Co-investigator on Project 2
    Description: Project 2: Neuroendocrine Regulation of LH in Normal and Disease States
    Time-Restricted Feeding and Breast Cancer
    NIH R01CA196853Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    SRSF3 Loss and Hepatocellular Carcinoma
    NIH I01BX002709Jan 1, 2016 - Dec 31, 2019
    Role: Principal Investigator
    Energetics and Breast Cancer: Obesity, Inflammation, Insulin Resistance & Risk
    NIH/NCI U54CA155435May 1, 2013 - Apr 30, 2018
    Role: Principal investigator on Project I
    Description: Project I: Role of inflammation and insulin resistance in mouse models of breast cancer
    Center for Reproductive Science and Medicine
    NIH/NICHD U54HD012303May 1, 2011 - Apr 30, 2016
    Role: Principal Investigator on Project II
    Description: Project II: The Interaction of Neuroendocrine Reproductive Function and Metabolic Signaling
    Small molecule activators of Trk receptors for neuroprotection in TBI
    DOD CDMRP PT090547Sep 1, 2010 - Aug 31, 2013
    Role: Principal Investigator
    Description: The project was to design small molecule activators of the Trk receptors for neuroprotection in mouse models of traumatic brain injury
    Alternative Splicing of the Insulin Receptor Gene
    NIH I01BX000130Apr 1, 2010 - Mar 31, 2014
    Role: Principal Investigator
    GnRH signaling in LbetaT2 gonadotrope cells
    NIH R01HD047400Jul 1, 2005 - Apr 30, 2011
    Role: Principal Investigator
    Combinatorial Approaches to Activators of the NGF Recep*
    NIH R03AG023191Dec 15, 2003 - Nov 30, 2005
    Role: Principal-investigator Project II
    Description: Project II: “The Interaction of Neuroendocrine Reproductive Function and Metabolic Signaling”.
    NIH R01DK044643Sep 30, 1992 - Sep 30, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis. Cell Metab. 2024 May 07; 36(5):1030-1043.e7. Isaac R, Bandyopadhyay G, Rohm TV, Kang S, Wang J, Pokhrel N, Sakane S, Zapata R, Libster AM, Vinik Y, Berhan A, Kisseleva T, Borok Z, Zick Y, Telese F, Webster NJG, Olefsky JM. PMID: 38670107; PMCID: PMC11113091.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Time-Restricted Feeding Attenuates Metabolic Dysfunction-Associated Steatohepatitis and Hepatocellular Carcinoma in Obese Male Mice. Cancers (Basel). 2024 Apr 16; 16(8). Das M, Kumar D, Sauceda C, Oberg A, Ellies LG, Zeng L, Jih LJ, Newton IG, Webster NJG. PMID: 38672595; PMCID: PMC11048121.
      View in: PubMed   Mentions: 1  
    3. Restoring SRSF3 in Kupffer cells attenuates obesity-related insulin resistance. Hepatology. 2024 Mar 08. Gao H, Rocha KCE, Jin Z, Kumar D, Zhang D, Wang K, Das M, Farrell A, Truong T, Tekin Y, Jung HS, Kempf J, Webster NJG, Ying W. PMID: 38456794.
      View in: PubMed   Mentions:    Fields:    
    4. Dysregulation of RNA splicing in early non-alcoholic fatty liver disease through hepatocellular carcinoma. Sci Rep. 2024 01 30; 14(1):2500. Webster NJG, Kumar D, Wu P. PMID: 38291075; PMCID: PMC10828381.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    5. Loss of cAMP Signaling in CD11c Immune Cells Protects Against Diet-Induced Obesity. Diabetes. 2023 09 01; 72(9):1235-1250. Zeng L, Herdman DS, Lee SM, Tao A, Das M, Bertin S, Eckmann L, Mahata SK, Wu P, Hara M, Byun JW, Devulapalli S, Patel HH, Molina AJA, Osborn O, Corr M, Raz E, Webster NJG. PMID: 37257047; PMCID: PMC10451016.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    6. Stimulating Antitumoral Immunity by Percutaneous Cryoablation and Combination Immunoadjuvant Therapy in a Murine Model of Hepatocellular Carcinoma. J Vasc Interv Radiol. 2023 09; 34(9):1516-1527.e6. Mandt T, Bangar A, Sauceda C, Das M, Moderbacher C, Ghani M, Webster N, Newton I. PMID: 37178816; PMCID: PMC10852103.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    7. Treatment of Hepatocellular Carcinoma by Multimodal In Situ Vaccination Using Cryoablation and a Plant Virus Immunostimulant. J Vasc Interv Radiol. 2023 07; 34(7):1247-1257.e8. Ghani MA, Bangar A, Yang Y, Jung E, Sauceda C, Mandt T, Shukla S, Webster NJG, Steinmetz NF, Newton IG. PMID: 36997021; PMCID: PMC10829876.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    8. Long-term exposure to house dust mites accelerates lung cancer development in mice. J Exp Clin Cancer Res. 2023 Jan 21; 42(1):26. Wang D, Li W, Albasha N, Griffin L, Chang H, Amaya L, Ganguly S, Zeng L, Keum B, González-Navajas JM, Levin M, AkhavanAghdam Z, Snyder H, Schwartz D, Tao A, Boosherhri LM, Hoffman HM, Rose M, Estrada MV, Varki N, Herdman S, Corr M, Webster NJG, Raz E, Bertin S. PMID: 36670473; PMCID: PMC9863279.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    9. A seven-transmembrane protein-TM7SF3, resides in nuclear speckles and regulates alternative splicing. iScience. 2022 Nov 18; 25(11):105270. Isaac R, Vinik Y, Mikl M, Nadav-Eliyahu S, Shatz-Azoulay H, Yaakobi A, DeForest N, Majithia AR, Webster NJG, Shav-Tal Y, Elhanany E, Zick Y. PMID: 36304109; PMCID: PMC9593240.
      View in: PubMed   Mentions: 1  
    10. The ECRG4 cleavage product augurin binds the endotoxin receptor and influences the innate immune response during otitis media. Front Genet. 2022; 13:932555. Kurabi A, Hur DG, Pak K, Gibson M, Webster NJG, Baird A, Eliceiri BP, Ryan AF. PMID: 36092940; PMCID: PMC9461705.
      View in: PubMed   Mentions:
    11. Obesity, cancer risk, and time-restricted eating. Cancer Metastasis Rev. 2022 09; 41(3):697-717. Das M, Webster NJG. PMID: 35984550; PMCID: PMC9470651.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    12. Hepatocyte Deletion of IGF2 Prevents DNA Damage and Tumor Formation in Hepatocellular Carcinoma. Adv Sci (Weinh). 2022 07; 9(21):e2105120. Kumar D, Das M, Oberg A, Sahoo D, Wu P, Sauceda C, Jih L, Ellies LG, Langiewicz MT, Sen S, Webster NJG. PMID: 35615981; PMCID: PMC9313545.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    13. Catestatin induces glycogenesis by stimulating the phosphoinositide 3-kinase-AKT pathway. Acta Physiol (Oxf). 2022 05; 235(1):e13775. Bandyopadhyay G, Tang K, Webster NJG, van den Bogaart G, Mahata SK. PMID: 34985191; PMCID: PMC10754386.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    14. Immunosuppression of Macrophages Underlies the Cardioprotective Effects of CST (Catestatin). Hypertension. 2021 05 05; 77(5):1670-1682. Ying W, Tang K, Avolio E, Schilling JM, Pasqua T, Liu MA, Cheng H, Gao H, Zhang J, Mahata S, Ko MS, Bandyopadhyay G, Das S, Roth DM, Sahoo D, Webster NJG, Sheikh F, Ghosh G, Patel HH, Ghosh P, van den Bogaart G, Mahata SK. PMID: 33826401; PMCID: PMC8116433.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    15. Alternative RNA Splicing in Fatty Liver Disease. Front Endocrinol (Lausanne). 2021; 12:613213. Wu P, Zhang M, Webster NJG. PMID: 33716968; PMCID: PMC7953061.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    16. Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models. Nat Commun. 2021 01 25; 12(1):565. Das M, Ellies LG, Kumar D, Sauceda C, Oberg A, Gross E, Mandt T, Newton IG, Kaur M, Sears DD, Webster NJG. PMID: 33495474; PMCID: PMC7835248.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    17. Mitochondrial Dysfunction in Obesity and Reproduction. Endocrinology. 2021 01 01; 162(1). Das M, Sauceda C, Webster NJG. PMID: 32945868; PMCID: PMC7709214.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    18. Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection. Front Genet. 2020; 11:358. Ryan AF, Nasamran CA, Pak K, Draf C, Fisch KM, Webster N, Kurabi A. PMID: 32351546; PMCID: PMC7174727.
      View in: PubMed   Mentions: 15  
    19. Chromogranin A pathway: from pathogenic molecule to renal disease. J Hypertens. 2020 03; 38(3):456-466. Mir SA, Biswas N, Cheung W, Wan J, Webster N, Macedo E, O'Connor DT, Vaingankar SM. PMID: 31714338; PMCID: PMC9109708.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    20. Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses. Elife. 2020 02 04; 9. Lee J, Zhang J, Chung YJ, Kim JH, Kook CM, González-Navajas JM, Herdman DS, Nürnberg B, Insel PA, Corr M, Mo JH, Tao A, Yasuda K, Rifkin IR, Broide DH, Sciammas R, Webster NJ, Raz E. PMID: 32014112; PMCID: PMC7000221.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    21. Degradation of splicing factor SRSF3 contributes to progressive liver disease. J Clin Invest. 2019 08 08; 129(10):4477-4491. Kumar D, Das M, Sauceda C, Ellies LG, Kuo K, Parwal P, Kaur M, Jih L, Bandyopadhyay GK, Burton D, Loomba R, Osborn O, Webster NJ. PMID: 31393851; PMCID: PMC6763247.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    22. SIRT1 in Astrocytes Regulates Glucose Metabolism and Reproductive Function. Endocrinology. 2019 06 01; 160(6):1547-1560. Choi I, Rickert E, Fernandez M, Webster NJG. PMID: 31127273; PMCID: PMC6542483.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    23. Neuronal SIRT1 Regulates Metabolic and Reproductive Function and the Response to Caloric Restriction. J Endocr Soc. 2019 Feb 01; 3(2):427-445. Rickert E, Fernandez MO, Choi I, Gorman M, Olefsky JM, Webster NJG. PMID: 30746504; PMCID: PMC6364627.
      View in: PubMed   Mentions: 5  
    24. Catestatin regulates vesicular quanta through modulation of cholinergic and peptidergic (PACAPergic) stimulation in PC12 cells. Cell Tissue Res. 2019 Apr; 376(1):51-70. Sahu BS, Mahata S, Bandyopadhyay K, Mahata M, Avolio E, Pasqua T, Sahu C, Bandyopadhyay GK, Bartolomucci A, Webster NJG, Van Den Bogaart G, Fischer-Colbrie R, Corti A, Eiden LE, Mahata SK. PMID: 30467710.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    25. Catestatin Inhibits Obesity-Induced Macrophage Infiltration and Inflammation in the Liver and Suppresses Hepatic Glucose Production, Leading to Improved Insulin Sensitivity. Diabetes. 2018 05; 67(5):841-848. Ying W, Mahata S, Bandyopadhyay GK, Zhou Z, Wollam J, Vu J, Mayoral R, Chi NW, Webster NJG, Corti A, Mahata SK. PMID: 29432123; PMCID: PMC6463753.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    26. Astrocyte-Specific Deletion of Peroxisome-Proliferator Activated Receptor-γ Impairs Glucose Metabolism and Estrous Cycling in Female Mice. J Endocr Soc. 2017 Nov 01; 1(11):1332-1350. Fernandez MO, Hsueh K, Park HT, Sauceda C, Hwang V, Kumar D, Kim S, Rickert E, Mahata S, Webster NJG. PMID: 29264458; PMCID: PMC5686676.
      View in: PubMed   Mentions: 9  
    27. Comparison of bone healing, as assessed by computed tomography, following tibial tuberosity advancement in dogs with and without autogenous cancellous bone grafts. N Z Vet J. 2017 Sep; 65(5):270-276. James DR, Webster N, White JD, Marchevsky AM, Cashmore RG, Havlicek M, Fearnside S, Black AP. PMID: 28637394.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    28. Alternative RNA Splicing in the Pathogenesis of Liver Disease. Front Endocrinol (Lausanne). 2017; 8:133. Webster NJG. PMID: 28680417; PMCID: PMC5478874.
      View in: PubMed   Mentions: 17     Fields:    
    29. Chromogranin A regulates vesicle storage and mitochondrial dynamics to influence insulin secretion. Cell Tissue Res. 2017 06; 368(3):487-501. Wollam J, Mahata S, Riopel M, Hernandez-Carretero A, Biswas A, Bandyopadhyay GK, Chi NW, Eiden LE, Mahapatra NR, Corti A, Webster NJG, Mahata SK. PMID: 28220294; PMCID: PMC10843982.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    30. Obese Neuronal PPARγ Knockout Mice Are Leptin Sensitive but Show Impaired Glucose Tolerance and Fertility. Endocrinology. 2017 01 01; 158(1):121-133. Fernandez MO, Sharma S, Kim S, Rickert E, Hsueh K, Hwang V, Olefsky JM, Webster NJ. PMID: 27841948; PMCID: PMC5412981.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    31. Muscle injury, impaired muscle function and insulin resistance in Chromogranin A-knockout mice. J Endocrinol. 2017 02; 232(2):137-153. Tang K, Pasqua T, Biswas A, Mahata S, Tang J, Tang A, Bandyopadhyay GK, Sinha-Hikim AP, Chi NW, Webster NJ, Corti A, Mahata SK. PMID: 27799464; PMCID: PMC5287349.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    32. Both canonical and non-canonical NF-κB activation contribute to the proliferative response of the middle ear mucosa during bacterial infection. Innate Immun. 2016 11; 22(8):626-634. Cho CG, Pak K, Webster N, Kurabi A, Ryan AF. PMID: 27655045; PMCID: PMC5333768.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    33. Time-restricted feeding improves insulin resistance and hepatic steatosis in a mouse model of postmenopausal obesity. Metabolism. 2016 Dec; 65(12):1743-1754. Chung H, Chou W, Sears DD, Patterson RE, Webster NJ, Ellies LG. PMID: 27832862; PMCID: PMC5123758.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    34. A Novel Gonadotropin-Releasing Hormone 1 (Gnrh1) Enhancer-Derived Noncoding RNA Regulates Gnrh1 Gene Expression in GnRH Neuronal Cell Models. PLoS One. 2016; 11(7):e0158597. Huang PP, Brusman LE, Iyer AK, Webster NJ, Mellon PL. PMID: 27389022; PMCID: PMC4936741.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    35. A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice. Biol Reprod. 2015 Sep; 93(3):69. Kauffman AS, Thackray VG, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba AJ, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon PL. PMID: 26203175; PMCID: PMC4710190.
      View in: PubMed   Mentions: 86     Fields:    Translation:Animals
    36. The transcriptome of a complete episode of acute otitis media. BMC Genomics. 2015 Apr 03; 16:259. Hernandez M, Leichtle A, Pak K, Webster NJ, Wasserman SI, Ryan AF. PMID: 25888408; PMCID: PMC4394589.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    37. Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1529-34. Lee J, Kim TH, Murray F, Li X, Choi SS, Broide DH, Corr M, Lee J, Webster NJ, Insel PA, Raz E. PMID: 25605931; PMCID: PMC4321256.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    38. Deletion of serine/arginine-rich splicing factor 3 in hepatocytes predisposes to hepatocellular carcinoma in mice. Hepatology. 2015 Jan; 61(1):171-83. Sen S, Langiewicz M, Jumaa H, Webster NJ. PMID: 25132062; PMCID: PMC4280350.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    39. C-Jun N-terminal kinase (JNK) isoforms play differing roles in otitis media. BMC Immunol. 2014 Oct 14; 15:46. Yao W, Frie M, Pan J, Pak K, Webster N, Wasserman SI, Ryan AF. PMID: 25311344; PMCID: PMC4200133.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    40. Omega-3 fatty acids reduce obesity-induced tumor progression independent of GPR120 in a mouse model of postmenopausal breast cancer. Oncogene. 2015 Jul; 34(27):3504-13. Chung H, Lee YS, Mayoral R, Oh DY, Siu JT, Webster NJ, Sears DD, Olefsky JM, Ellies LG. PMID: 25220417; PMCID: PMC4362785.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    41. Molecular tumor board: the University of California-San Diego Moores Cancer Center experience. Oncologist. 2014 Jun; 19(6):631-6. Schwaederle M, Parker BA, Schwab RB, Fanta PT, Boles SG, Daniels GA, Bazhenova LA, Subramanian R, Coutinho AC, Ojeda-Fournier H, Datnow B, Webster NJ, Lippman SM, Kurzrock R. PMID: 24797821; PMCID: PMC4041669.
      View in: PubMed   Mentions: 86     Fields:    Translation:Humans
    42. Free fatty acids induce Lhb mRNA but suppress Fshb mRNA in pituitary LβT2 gonadotropes and diet-induced obesity reduces FSH levels in male mice and disrupts the proestrous LH/FSH surge in female mice. Endocrinology. 2013 Jun; 154(6):2188-99. Sharma S, Morinaga H, Hwang V, Fan W, Fernandez MO, Varki N, Olefsky JM, Webster NJ. PMID: 23525221; PMCID: PMC3740488.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    43. Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function. Nat Commun. 2013; 4:1336. Sen S, Jumaa H, Webster NJ. PMID: 23299886; PMCID: PMC4314219.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    44. Whole genome analysis of Leptospira licerasiae provides insight into leptospiral evolution and pathogenicity. PLoS Negl Trop Dis. 2012; 6(10):e1853. Ricaldi JN, Fouts DE, Selengut JD, Harkins DM, Patra KP, Moreno A, Lehmann JS, Purushe J, Sanka R, Torres M, Webster NJ, Vinetz JM, Matthias MA. PMID: 23145189; PMCID: PMC3493377.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    45. hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene. PLoS One. 2011; 6(11):e27869. Talukdar I, Sen S, Urbano R, Thompson J, Yates JR, Webster NJ. PMID: 22132154; PMCID: PMC3223206.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    46. Cortactin, an actin binding protein, regulates GLUT4 translocation via actin filament remodeling. Biochemistry (Mosc). 2011 Nov; 76(11):1262-9. Nazari H, Khaleghian A, Takahashi A, Harada N, Webster NJ, Nakano M, Kishi K, Ebina Y, Nakaya Y. PMID: 22117553; PMCID: PMC4313749.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    47. Gonadotropin-releasing hormone pulse sensitivity of follicle-stimulating hormone-beta gene is mediated by differential expression of positive regulatory activator protein 1 factors and corepressors SKIL and TGIF1. Mol Endocrinol. 2011 Aug; 25(8):1387-403. Mistry DS, Tsutsumi R, Fernandez M, Sharma S, Cardenas SA, Lawson MA, Webster NJ. PMID: 21659477; PMCID: PMC3146254.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    48. Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHβ gene expression by a SirT1-independent pathway in LβT2 gonadotrope cells. Reprod Toxicol. 2011 Jul; 32(1):85-92. Lan D, Lu M, Sharma S, Mellon PL, Olefsky JM, Webster NJ. PMID: 21679764; PMCID: PMC3155991.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    49. Brain PPAR-γ promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones. Nat Med. 2011 May; 17(5):618-22. Lu M, Sarruf DA, Talukdar S, Sharma S, Li P, Bandyopadhyay G, Nalbandian S, Fan W, Gayen JR, Mahata SK, Webster NJ, Schwartz MW, Olefsky JM. PMID: 21532596; PMCID: PMC3380629.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
    50. Gonadotropin-releasing hormone induces miR-132 and miR-212 to regulate cellular morphology and migration in immortalized LbetaT2 pituitary gonadotrope cells. Mol Endocrinol. 2011 May; 25(5):810-20. Godoy J, Nishimura M, Webster NJ. PMID: 21372146; PMCID: PMC3082323.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    51. The role of DNA sensing and innate immune receptor TLR9 in otitis media. Innate Immun. 2012 Feb; 18(1):3-13. Leichtle A, Hernandez M, Lee J, Pak K, Webster NJ, Wollenberg B, Wasserman SI, Ryan AF. PMID: 21239460; PMCID: PMC4041324.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    52. PPARG regulates gonadotropin-releasing hormone signaling in LbetaT2 cells in vitro and pituitary gonadotroph function in vivo in mice. Biol Reprod. 2011 Mar; 84(3):466-75. Sharma S, Sharma PM, Mistry DS, Chang RJ, Olefsky JM, Mellon PL, Webster NJ. PMID: 21076077; PMCID: PMC3043129.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    53. Modulation of gonadotropin-releasing hormone-induced extracellular signal-regulated kinase activation by dual-specificity protein phosphatase 1 in LbetaT2 gonadotropes. Endocrinology. 2010 Oct; 151(10):4882-93. Nguyen KA, Intriago RE, Upadhyay HC, Santos SJ, Webster NJ, Lawson MA. PMID: 20685880; PMCID: PMC2946148.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    54. Muscleblind-like 1 (Mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer. J Biol Chem. 2010 Aug 13; 285(33):25426-37. Sen S, Talukdar I, Liu Y, Tam J, Reddy S, Webster NJ. PMID: 20519504; PMCID: PMC2919106.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    55. Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10638-43. Datta SK, Sabet M, Nguyen KP, Valdez PA, Gonzalez-Navajas JM, Islam S, Mihajlov I, Fierer J, Insel PA, Webster NJ, Guiney DG, Raz E. PMID: 20479237; PMCID: PMC2890829.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    56. Signaling responses to pulsatile gonadotropin-releasing hormone in LbetaT2 gonadotrope cells. J Biol Chem. 2010 Jun 25; 285(26):20262-72. Tsutsumi R, Mistry D, Webster NJ. PMID: 20406815; PMCID: PMC2888439.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    57. The toll-Like receptor adaptor TRIF contributes to otitis media pathogenesis and recovery. BMC Immunol. 2009 Aug 05; 10:45. Leichtle A, Hernandez M, Pak K, Webster NJ, Wasserman SI, Ryan AF. PMID: 19656404; PMCID: PMC2736931.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    58. GnRH pulsatility, the pituitary response and reproductive dysfunction. Endocr J. 2009; 56(6):729-37. Tsutsumi R, Webster NJ. PMID: 19609045; PMCID: PMC4307809.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimals
    59. TLR4-mediated induction of TLR2 signaling is critical in the pathogenesis and resolution of otitis media. Innate Immun. 2009 Aug; 15(4):205-15. Leichtle A, Hernandez M, Pak K, Yamasaki K, Cheng CF, Webster NJ, Ryan AF, Wasserman SI. PMID: 19586996; PMCID: PMC3565845.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    60. Curcumin disrupts the Mammalian target of rapamycin-raptor complex. Cancer Res. 2009 Feb 01; 69(3):1000-8. Beevers CS, Chen L, Liu L, Luo Y, Webster NJ, Huang S. PMID: 19176385; PMCID: PMC4307947.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansCells
    61. Myeloid differentiation primary response gene 88 is required for the resolution of otitis media. J Infect Dis. 2008 Dec 15; 198(12):1862-9. Hernandez M, Leichtle A, Pak K, Ebmeyer J, Euteneuer S, Obonyo M, Guiney DG, Webster NJ, Broide DH, Ryan AF, Wasserman SI. PMID: 18986247; PMCID: PMC3584630.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    62. Small molecule activators of the Trk receptors for neuroprotection. BMC Neurosci. 2008 Dec 03; 9 Suppl 2:S1. Webster NJ, Pirrung MC. PMID: 19090982; PMCID: PMC2604901.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    63. SRp20 and CUG-BP1 modulate insulin receptor exon 11 alternative splicing. Mol Cell Biol. 2009 Feb; 29(3):871-80. Sen S, Talukdar I, Webster NJ. PMID: 19047369; PMCID: PMC2630670.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    64. Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-kappaB/PTEN suppression. J Biol Chem. 2008 Sep 05; 283(36):24889-98. Chandrasekar B, Boylston WH, Venkatachalam K, Webster NJ, Prabhu SD, Valente AJ. PMID: 18632660; PMCID: PMC3259831.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    65. Quinone replacements for small molecule insulin mimics. Chembiochem. 2008 Feb 15; 9(3):360-2. Pirrung MC, Deng L, Lin B, Webster NJ. PMID: 18232038.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    66. Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes. Mol Endocrinol. 2008 Mar; 22(3):760-71. Lu M, Tang Q, Olefsky JM, Mellon PL, Webster NJ. PMID: 18006641; PMCID: PMC2262174.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    67. Identification of novel orally available small molecule insulin mimetics. J Pharmacol Exp Ther. 2007 Nov; 323(2):579-85. Lin B, Li Z, Park K, Deng L, Pai A, Zhong L, Pirrung MC, Webster NJ. PMID: 17687071.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    68. Parallel synthesis of indolylquinones and their cell-based insulin mimicry. J Comb Chem. 2007 Sep-Oct; 9(5):844-54. Pirrung MC, Li Z, Hensley E, Liu Y, Tanksale A, Lin B, Pai A, Webster NJ. PMID: 17595147.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    69. Neuroprotection by small molecule activators of the nerve growth factor receptor. J Pharmacol Exp Ther. 2007 Jul; 322(1):59-69. Lin B, Pirrung MC, Deng L, Li Z, Liu Y, Webster NJ. PMID: 17468299.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    70. Jun N-terminal protein kinase enhances middle ear mucosal proliferation during bacterial otitis media. Infect Immun. 2007 May; 75(5):2562-71. Furukawa M, Ebmeyer J, Pak K, Austin DA, Melhus A, Webster NJ, Ryan AF. PMID: 17325051; PMCID: PMC1865762.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    71. Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2. Mol Endocrinol. 2007 May; 21(5):1175-91. Lawson MA, Tsutsumi R, Zhang H, Talukdar I, Butler BK, Santos SJ, Mellon PL, Webster NJ. PMID: 17299135; PMCID: PMC2932486.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    72. A PI3K pathway mediates hair cell survival and opposes gentamicin toxicity in neonatal rat organ of Corti. J Assoc Res Otolaryngol. 2006 Dec; 7(4):373-82. Chung WH, Pak K, Lin B, Webster N, Ryan AF. PMID: 17053865; PMCID: PMC2504631.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    73. Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing. EMBO J. 2006 Sep 20; 25(18):4271-83. Paul S, Dansithong W, Kim D, Rossi J, Webster NJ, Comai L, Reddy S. PMID: 16946708; PMCID: PMC1570429.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansCells
    74. Effect of TRB3 on insulin and nutrient-stimulated hepatic p70 S6 kinase activity. J Biol Chem. 2006 Oct 06; 281(40):29719-29. Matsushima R, Harada N, Webster NJ, Tsutsumi YM, Nakaya Y. PMID: 16887816.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    75. Activin modulates the transcriptional response of LbetaT2 cells to gonadotropin-releasing hormone and alters cellular proliferation. Mol Endocrinol. 2006 Nov; 20(11):2909-30. Zhang H, Bailey JS, Coss D, Lin B, Tsutsumi R, Lawson MA, Mellon PL, Webster NJ. PMID: 16772531; PMCID: PMC2673912.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    76. Constitutively active Gq impairs gonadotropin-releasing hormone-induced intracellular signaling and luteinizing hormone secretion in LbetaT2 cells. Mol Endocrinol. 2005 Aug; 19(8):2074-85. Liu F, Ruiz MS, Austin DA, Webster NJ. PMID: 15878957.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    77. Methyl scanning: total synthesis of demethylasterriquinone B1 and derivatives for identification of sites of interaction with and isolation of its receptor(s). J Am Chem Soc. 2005 Apr 06; 127(13):4609-24. Pirrung MC, Liu Y, Deng L, Halstead DK, Li Z, May JF, Wedel M, Austin DA, Webster NJ. PMID: 15796526.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    78. Role of p38 mitogen-activated protein kinase in middle ear mucosa hyperplasia during bacterial otitis media. Infect Immun. 2004 Aug; 72(8):4662-7. Palacios SD, Pak K, Rivkin AZ, Kayali AG, Austen D, Aletsee C, Melhus A, Webster NJ, Ryan AF. PMID: 15271927; PMCID: PMC470656.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    79. Assembly of splicing complexes on exon 11 of the human insulin receptor gene does not correlate with splicing efficiency in-vitro. BMC Mol Biol. 2004 Jul 02; 5:7. Webster NJ, Evans LG, Caples M, Erker L, Chew SL. PMID: 15233842; PMCID: PMC481066.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    80. Gonadotropin-releasing hormone-desensitized LbetaT2 gonadotrope cells are refractory to acute protein kinase C, cyclic AMP, and calcium-dependent signaling. Endocrinology. 2003 Oct; 144(10):4354-65. Liu F, Austin DA, Webster NJ. PMID: 12960037.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    81. Signaling effects of demethylasterriquinone B1, a selective insulin receptor modulator. Chembiochem. 2003 May 09; 4(5):379-85. Webster NJ, Park K, Pirrung MC. PMID: 12740809.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    82. Participation of Ras and extracellular regulated kinase in the hyperplastic response of middle-ear mucosa during bacterial otitis media. J Infect Dis. 2002 Dec 15; 186(12):1761-9. Palacios SD, Pak K, Kayali AG, Rivkin AZ, Aletsee C, Melhus A, Webster NJ, Ryan AF. PMID: 12447762.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    83. Rottlerin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes by uncoupling mitochondrial oxidative phosphorylation. Endocrinology. 2002 Oct; 143(10):3884-96. Kayali AG, Austin DA, Webster NJ. PMID: 12239100.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    84. Different signaling pathways control acute induction versus long-term repression of LHbeta transcription by GnRH. Endocrinology. 2002 Sep; 143(9):3414-26. Vasilyev VV, Lawson MA, Dipaolo D, Webster NJ, Mellon PL. PMID: 12193554; PMCID: PMC2932485.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    85. PLCgamma participates in insulin stimulation of glucose uptake through activation of PKCzeta in brown adipocytes. Exp Cell Res. 2002 Aug 15; 278(2):146-57. Lorenzo M, Teruel T, Hernandez R, Kayali AG, Webster NJ. PMID: 12169270.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    86. Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells. J Biol Chem. 2002 Aug 30; 277(35):32099-108. Liu F, Usui I, Evans LG, Austin DA, Mellon PL, Olefsky JM, Webster NJ. PMID: 12050161; PMCID: PMC2930616.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    87. Retroviral expression of a kinase-defective IGF-I receptor suppresses growth and causes apoptosis of CHO and U87 cells in-vivo. BMC Cancer. 2002 May 31; 2:15. Seely BL, Samimi G, Webster NJ. PMID: 12057025; PMCID: PMC115841.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    88. Transcriptional activation of the ovine follicle-stimulating hormone-beta gene by gonadotropin-releasing hormone involves multiple signal transduction pathways. Endocrinology. 2002 May; 143(5):1651-9. Vasilyev VV, Pernasetti F, Rosenberg SB, Barsoum MJ, Austin DA, Webster NJ, Mellon PL. PMID: 11956146; PMCID: PMC2930615.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    89. GnRH activates ERK1/2 leading to the induction of c-fos and LHbeta protein expression in LbetaT2 cells. Mol Endocrinol. 2002 Mar; 16(3):419-34. Liu F, Austin DA, Mellon PL, Olefsky JM, Webster NJ. PMID: 11875099.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    90. PLC-gamma1 enzyme activity is required for insulin-induced DNA synthesis. Endocrinology. 2002 Feb; 143(2):655-64. Eichhorn J, Kayali AG, Resor L, Austin DA, Rose DW, Webster NJ. PMID: 11796522.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    91. Differential effects of unaggregated and aggregated amyloid beta protein (1-40) on K(+) channel currents in primary cultures of rat cerebellar granule and cortical neurones. J Neurochem. 2001 Nov; 79(3):699-712. Ramsden M, Plant LD, Webster NJ, Vaughan PF, Henderson Z, Pearson HA. PMID: 11701773.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    92. Hypoxic enhancement of evoked noradrenaline release from the human neuroblastoma SH-SY5Y. Brain Res Mol Brain Res. 2001 Apr 18; 89(1-2):50-7. Webster NJ, Vaughan PF, Peers C. PMID: 11311975.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    93. Insulin activates phospholipase C-gamma1 via a PI-3 kinase dependent mechanism in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2001 Mar 30; 282(2):615-20. Eichhorn J, Kayali AG, Austin DA, Webster NJ. PMID: 11401505.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    94. Inhibition of depolarisation-evoked [(3)H]noradrenaline release from SH-SYFY human neuroblastoma cells by muscarinic (M1) receptors is not mediated by changes in [Ca(2+)]. Brain Res Mol Brain Res. 2001 Feb 19; 87(1):81-91. Roberts DJ, Khan N, McDonald RL, Webster NJ, Peers C, Vaughan PF. PMID: 11223162.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    95. Stimulation of MAPK cascades by insulin and osmotic shock: lack of an involvement of p38 mitogen-activated protein kinase in glucose transport in 3T3-L1 adipocytes. Diabetes. 2000 Nov; 49(11):1783-93. Kayali AG, Austin DA, Webster NJ. PMID: 11078444.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    96. Induction of insulin resistance in human skeletal muscle cells by downregulation of glycogen synthase protein expression. Metabolism. 2000 Aug; 49(8):962-8. Park KS, Ciaraldi TP, Carter L, Mudaliar S, Nikoulina SE, Webster NJ, Henry RR. PMID: 10954011.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    97. Inhibition of PLC-gamma1 activity converts nerve growth factor from an anti-mitogenic to a mitogenic signal in CHO cells. Oncogene. 1999 Sep 02; 18(35):4908-19. Zapf-Colby A, Eichhorn J, Webster NJ, Olefsky JM. PMID: 10490825.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    98. Hormonal regulation of alternative splicing. Front Horm Res. 1999; 25:1-17. Webster NJ, Huang Z. PMID: 10941399.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    99. Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin. J Biol Chem. 1998 May 29; 273(22):13808-18. Kayali AG, Eichhorn J, Haruta T, Morris AJ, Nelson JG, Vollenweider P, Olefsky JM, Webster NJ. PMID: 9593725.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    100. Identification of intron and exon sequences involved in alternative splicing of insulin receptor pre-mRNA. J Biol Chem. 1998 Apr 24; 273(17):10331-7. Kosaki A, Nelson J, Webster NJ. PMID: 9553088.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    101. Elevated insulin-like growth factor I receptor autophosphorylation and kinase activity in human breast cancer. Cancer Res. 1998 Mar 15; 58(6):1159-64. Resnik JL, Reichart DB, Huey K, Webster NJ, Seely BL. PMID: 9515800.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    102. K(+)-induced dilation of a small renal artery: no role for inward rectifier K+ channels. Cardiovasc Res. 1998 Mar; 37(3):780-90. Prior HM, Webster N, Quinn K, Beech DJ, Yates MS. PMID: 9659463.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    103. Differential effects of Wilms tumor WT1 splice variants on the insulin receptor promoter. Biochem Mol Med. 1997 Dec; 62(2):139-50. Webster NJ, Kong Y, Sharma P, Haas M, Sukumar S, Seely BL. PMID: 9441865.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    104. Repression of the insulin receptor promoter by the tumor suppressor gene product p53: a possible mechanism for receptor overexpression in breast cancer. Cancer Res. 1996 Jun 15; 56(12):2781-8. Webster NJ, Resnik JL, Reichart DB, Strauss B, Haas M, Seely BL. PMID: 8665514.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    105. Altered insulin receptor messenger ribonucleic acid splicing in liver is associated with deterioration of glucose tolerance in the spontaneously obese and diabetic rhesus monkey: analysis of controversy between monkey and human studies. J Clin Endocrinol Metab. 1996 Apr; 81(4):1552-6. Huang Z, Bodkin NL, Ortmeyer HK, Zenilman ME, Webster NJ, Hansen BC, Shuldiner AR. PMID: 8636366.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    106. Starvation and refeeding regulate glycogen synthase gene expression in rat liver at the posttranscriptional level. J Nutr. 1995 Oct; 125(10):2457-62. Nur T, Sela I, Webster NJ, Madar Z. PMID: 7562079.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    107. The B isoform of the insulin receptor signals more efficiently than the A isoform in HepG2 cells. J Biol Chem. 1995 Sep 01; 270(35):20816-23. Kosaki A, Pillay TS, Xu L, Webster NJ. PMID: 7657666.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    108. A functional cyclic AMP response element plays a crucial role in neuroendocrine cell type-specific expression of the secretory granule protein chromogranin A. J Clin Invest. 1995 Jul; 96(1):568-78. Wu H, Mahata SK, Mahata M, Webster NJ, Parmer RJ, O'Connor DT. PMID: 7615829; PMCID: PMC185231.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    109. Cell type-specific gene expression in the neuroendocrine system. A neuroendocrine-specific regulatory element in the promoter of chromogranin A, a ubiquitous secretory granule core protein. J Clin Invest. 1994 Jul; 94(1):118-29. Wu H, Rozansky DJ, Webster NJ, O'Connor DT. PMID: 8040254; PMCID: PMC296289.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    110. An upstream element from the human insulin receptor gene promoter contains binding sites for C/EBP beta and NF-1. Diabetes. 1994 Feb; 43(2):305-12. Webster NJ, Kong Y, Cameron KE, Resnik JL. PMID: 8288055.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    111. Deletion of exon 21 of the insulin receptor eliminates tyrosine kinase activity but preserves mitogenic signaling. Biochemistry. 1993 Dec 14; 32(49):13545-50. Rolband GC, Williams JF, Webster NJ, Hsu D, Olefsky JM. PMID: 8257690.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    112. Effect of dexamethasone on the alternative splicing of the insulin receptor mRNA and insulin action in HepG2 hepatoma cells. J Biol Chem. 1993 Oct 15; 268(29):21990-6. Kosaki A, Webster NJ. PMID: 8408055.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    113. The insulin receptor C-terminus is involved in regulation of the receptor kinase activity. Biochemistry. 1993 Sep 21; 32(37):9539-44. Kaliman P, Baron V, Alengrin F, Takata Y, Webster NJ, Olefsky JM, Van Obberghen E. PMID: 7690586.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    114. Deletion of the insulin receptor beta-subunit acidic domain results in enhanced metabolic signaling. Endocrinology. 1993 Sep; 133(3):1437-43. Rolband GC, Williams JF, Webster NJ, Olefsky JM. PMID: 8396020.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    115. Relative expression of insulin receptor isoforms does not differ in lean, obese, and noninsulin-dependent diabetes mellitus subjects. J Clin Endocrinol Metab. 1993 May; 76(5):1380-2. Anderson CM, Henry RR, Knudson PE, Olefsky JM, Webster NJ. PMID: 7684396.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    116. Transcriptional regulation of the human insulin receptor promoter. J Biol Chem. 1992 Aug 25; 267(24):17375-83. Cameron KE, Resnik J, Webster NJ. PMID: 1324934.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    117. Intracellular signaling by a mutant human insulin receptor lacking the carboxyl-terminal tyrosine autophosphorylation sites. J Biol Chem. 1992 May 05; 267(13):9065-70. Takata Y, Webster NJ, Olefsky JM. PMID: 1577744.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    118. Mutation of the two carboxyl-terminal tyrosines results in an insulin receptor with normal metabolic signaling but enhanced mitogenic signaling properties. J Biol Chem. 1991 May 15; 266(14):9135-9. Takata Y, Webster NJ, Olefsky JM. PMID: 2026614.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    119. A domain of the insulin receptor required for endocytosis in rat fibroblasts. J Biol Chem. 1990 Jun 15; 265(17):10132-7. Thies RS, Webster NJ, McClain DA. PMID: 2161833.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    120. The human estrogen receptor has two independent nonacidic transcriptional activation functions. Cell. 1989 Nov 03; 59(3):477-87. Tora L, White J, Brou C, Tasset D, Webster N, Scheer E, Chambon P. PMID: 2805068.
      View in: PubMed   Mentions: 269     Fields:    Translation:HumansAnimalsCells
    121. The transcriptional activation function located in the hormone-binding domain of the human oestrogen receptor is not encoded in a single exon. EMBO J. 1989 May; 8(5):1441-6. Webster NJ, Green S, Tasset D, Ponglikitmongkol M, Chambon P. PMID: 2767048; PMCID: PMC400972.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    122. The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function. Cell. 1988 Jul 15; 54(2):199-207. Webster NJ, Green S, Jin JR, Chambon P. PMID: 3390864.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansCells
    123. The yeast UASG is a transcriptional enhancer in human HeLa cells in the presence of the GAL4 trans-activator. Cell. 1988 Jan 29; 52(2):169-78. Webster N, Jin JR, Green S, Hollis M, Chambon P. PMID: 2830022.
      View in: PubMed   Mentions: 145     Fields:    Translation:HumansAnimalsCells
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