Nicholas Webster

Title(s)Professor In Residence, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    University of Cambridge, Cambridge, UKBA, MA06/1981Natural Sciences
    Stanford University, Stanford, CAPhD08/1986Chemistry
    CNRS, Strasbourg, FrancePost-doc12/1988Molecular Biology

    Collapse Overview 
    Collapse Overview
    My lab is interested in mechanisms of signal transduction and gene regulation in different developmental and disease contexts. One of the current projects is to analyze the role of alternative splicing in liver development, metabolism and disease. They have created hepatocyte-specific knockouts of the splicing factors SRSF1 and SRSF3. They have previously these factors regulate insulin receptor splicing and promote inclusion of a small cassette exon 11 in the C-terminus of the hormone-binding domain. Deletion of SRSF3 impairs splicing of selected RNA isoforms resulting in inhibition of hepatocyte maturation, impairment of lipid and glucose metabolism, and generation endoplasmic reticulum stress. These defects result in a continual regeneration phenotype with increased proliferation and apoptosis, cellular pleiomorphism, eventually leading to fibrosis and hepatocellular adenoma formation and progression to hepatocellular carcinoma that metastasizes to the lung. This knockout thus represents a valuable model for human HCC as many of the same genes are altered.
    Another goal of our research is to investigate how changes in GnRH pulse frequency alter gene expression and secretory function in pituitary gonadotropes. Much of the work is based on the application of genomic technologies to understand the changes in mRNA expression and cell phenotype during response to pulsatile hypothalamic stimulation. We have used these genomic approaches to generate models of regulation that we are in the process of testing experimentally. We are also investigating how metabolic derangements alter reproductive function through effects on hypothalamic-pituitary signaling.
    My lab is also investigating the effects of obesity on breast cancer initiation and progression. Mouse mammary tumor cells form larger, more aggressive tumors in obese mice. The same acceleration is seen with both genetic and diet-induced obesity. The mammary fat pad in the obese mouse expresses high levels of TNFα and we have shown that this cytokine stimulates cancer cell proliferation in vitro. The lab is studying how omega-3 fatty acids, which are anti-inflammatory, can reverse the obesity effect on breast cancer growth.

    Collapse Research 
    Collapse Research Activities and Funding
    BLR&D Research Career Scientist Award Application
    NIH IK6BX005224Apr 1, 2020 - Mar 31, 2027
    Role: Principal Investigator
    SRSF3 degradation in liver disease and hepatocellular carcinoma
    NIH I01BX004848Apr 1, 2020 - Mar 31, 2024
    Role: Principal Investigator
    A novel pathway of Th17/Th2 induction: The role of cAMP signaling in DC
    NIH R01HL141999Jan 1, 2019 - Dec 31, 2022
    Role: Co-Principal Investigator
    ShEEP Request for Beckman-Coulter Optima XPN 100 Ultracentrifuge
    NIH IS1BX004386Jan 1, 2018 - Sep 30, 2018
    Role: Principal Investigator
    Time-Restricted Feeding and Breast Cancer
    NIH R01CA196853Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    SRSF3 Loss and Hepatocellular Carcinoma
    NIH I01BX002709Jan 1, 2016 - Dec 31, 2019
    Role: Principal Investigator
    Alternative Splicing of the Insulin Receptor Gene
    NIH I01BX000130Apr 1, 2010 - Mar 31, 2014
    Role: Principal Investigator
    GnRH signaling in LbetaT2 gonadotrope cells
    NIH R01HD047400Jul 1, 2005 - Apr 30, 2011
    Role: Principal Investigator
    Combinatorial Approaches to Activators of the NGF Recep*
    NIH R03AG023191Dec 15, 2003 - Nov 30, 2005
    Role: Principal Investigator
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator
    NIH R01DK044643Sep 30, 1992 - Sep 30, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Immunosuppression of Macrophages Underlies the Cardioprotective Effects of CST (Catestatin). Hypertension. 2021 May 05; 77(5):1670-1682. Ying W, Tang K, Avolio E, Schilling JM, Pasqua T, Liu MA, Cheng H, Gao H, Zhang J, Mahata S, Ko MS, Bandyopadhyay G, Das S, Roth DM, Sahoo D, Webster NJG, Sheikh F, Ghosh G, Patel HH, Ghosh P, van den Bogaart G, Mahata SK. PMID: 33826401.
      View in: PubMed   Mentions:    Fields:    
    2. Alternative RNA Splicing in Fatty Liver Disease. Front Endocrinol (Lausanne). 2021; 12:613213. Wu P, Zhang M, Webster NJG. PMID: 33716968.
      View in: PubMed   Mentions:
    3. Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models. Nat Commun. 2021 01 25; 12(1):565. Das M, Ellies LG, Kumar D, Sauceda C, Oberg A, Gross E, Mandt T, Newton IG, Kaur M, Sears DD, Webster NJG. PMID: 33495474.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Mitochondrial Dysfunction in Obesity and Reproduction. Endocrinology. 2021 Jan 01; 162(1). Das M, Sauceda C, Webster NJG. PMID: 32945868.
      View in: PubMed   Mentions: 1     Fields:    
    5. Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection. Front Genet. 2020; 11:358. Ryan AF, Nasamran CA, Pak K, Draf C, Fisch KM, Webster N, Kurabi A. PMID: 32351546.
      View in: PubMed   Mentions:
    6. Chromogranin A pathway: from pathogenic molecule to renal disease. J Hypertens. 2020 03; 38(3):456-466. Mir SA, Biswas N, Cheung W, Wan J, Webster N, Macedo E, O'Connor DT, Vaingankar SM. PMID: 31714338.
      View in: PubMed   Mentions:    Fields:    
    7. Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses. Elife. 2020 Feb 04; 9. Lee J, Zhang J, Chung YJ, Kim JH, Kook CM, González-Navajas JM, Herdman DS, Nürnberg B, Insel PA, Corr M, Mo JH, Tao A, Yasuda K, Rifkin IR, Broide DH, Sciammas R, Webster NJ, Raz E. PMID: 32014112.
      View in: PubMed   Mentions: 1     Fields:    
    8. Degradation of splicing factor SRSF3 contributes to progressive liver disease. J Clin Invest. 2019 08 08; 129(10):4477-4491. Kumar D, Das M, Sauceda C, Ellies LG, Kuo K, Parwal P, Kaur M, Jih L, Bandyopadhyay GK, Burton D, Loomba R, Osborn O, Webster NJ. PMID: 31393851.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    9. SIRT1 in Astrocytes Regulates Glucose Metabolism and Reproductive Function. Endocrinology. 2019 06 01; 160(6):1547-1560. Choi I, Rickert E, Fernandez M, Webster NJG. PMID: 31127273.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    10. Neuronal SIRT1 Regulates Metabolic and Reproductive Function and the Response to Caloric Restriction. J Endocr Soc. 2019 Feb 01; 3(2):427-445. Rickert E, Fernandez MO, Choi I, Gorman M, Olefsky JM, Webster NJG. PMID: 30746504.
      View in: PubMed   Mentions:
    11. Catestatin regulates vesicular quanta through modulation of cholinergic and peptidergic (PACAPergic) stimulation in PC12 cells. Cell Tissue Res. 2019 Apr; 376(1):51-70. Sahu BS, Mahata S, Bandyopadhyay K, Mahata M, Avolio E, Pasqua T, Sahu C, Bandyopadhyay GK, Bartolomucci A, Webster NJG, Van Den Bogaart G, Fischer-Colbrie R, Corti A, Eiden LE, Mahata SK. PMID: 30467710.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    12. Catestatin Inhibits Obesity-Induced Macrophage Infiltration and Inflammation in the Liver and Suppresses Hepatic Glucose Production, Leading to Improved Insulin Sensitivity. Diabetes. 2018 05; 67(5):841-848. Ying W, Mahata S, Bandyopadhyay GK, Zhou Z, Wollam J, Vu J, Mayoral R, Chi NW, Webster NJG, Corti A, Mahata SK. PMID: 29432123.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    13. Astrocyte-Specific Deletion of Peroxisome-Proliferator Activated Receptor-? Impairs Glucose Metabolism and Estrous Cycling in Female Mice. J Endocr Soc. 2017 Nov 01; 1(11):1332-1350. Fernandez MO, Hsueh K, Park HT, Sauceda C, Hwang V, Kumar D, Kim S, Rickert E, Mahata S, Webster NJG. PMID: 29264458.
      View in: PubMed   Mentions:
    14. Alternative RNA Splicing in the Pathogenesis of Liver Disease. Front Endocrinol (Lausanne). 2017; 8:133. Webster NJG. PMID: 28680417.
      View in: PubMed   Mentions:
    15. Chromogranin A regulates vesicle storage and mitochondrial dynamics to influence insulin secretion. Cell Tissue Res. 2017 06; 368(3):487-501. Wollam J, Mahata S, Riopel M, Hernandez-Carretero A, Biswas A, Bandyopadhyay GK, Chi NW, Eiden LE, Mahapatra NR, Corti A, Webster NJG, Mahata SK. PMID: 28220294.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    16. Obese Neuronal PPAR? Knockout Mice Are Leptin Sensitive but Show Impaired Glucose Tolerance and Fertility. Endocrinology. 2017 01 01; 158(1):121-133. Fernandez MO, Sharma S, Kim S, Rickert E, Hsueh K, Hwang V, Olefsky JM, Webster NJ. PMID: 27841948.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    17. Muscle injury, impaired muscle function and insulin resistance in Chromogranin A-knockout mice. J Endocrinol. 2017 02; 232(2):137-153. Tang K, Pasqua T, Biswas A, Mahata S, Tang J, Tang A, Bandyopadhyay GK, Sinha-Hikim AP, Chi NW, Webster NJ, Corti A, Mahata SK. PMID: 27799464.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    18. Both canonical and non-canonical NF-?B activation contribute to the proliferative response of the middle ear mucosa during bacterial infection. Innate Immun. 2016 11; 22(8):626-634. Cho CG, Pak K, Webster N, Kurabi A, Ryan AF. PMID: 27655045.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    19. Time-restricted feeding improves insulin resistance and hepatic steatosis in a mouse model of postmenopausal obesity. Metabolism. 2016 Dec; 65(12):1743-1754. Chung H, Chou W, Sears DD, Patterson RE, Webster NJ, Ellies LG. PMID: 27832862.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    20. A Novel Gonadotropin-Releasing Hormone 1 (Gnrh1) Enhancer-Derived Noncoding RNA Regulates Gnrh1 Gene Expression in GnRH Neuronal Cell Models. PLoS One. 2016; 11(7):e0158597. Huang PP, Brusman LE, Iyer AK, Webster NJ, Mellon PL. PMID: 27389022.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    21. A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice. Biol Reprod. 2015 Sep; 93(3):69. Kauffman AS, Thackray VG, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba AJ, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon PL. PMID: 26203175.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    22. The transcriptome of a complete episode of acute otitis media. BMC Genomics. 2015 Apr 03; 16:259. Hernandez M, Leichtle A, Pak K, Webster NJ, Wasserman SI, Ryan AF. PMID: 25888408.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    23. Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1529-34. Lee J, Kim TH, Murray F, Li X, Choi SS, Broide DH, Corr M, Lee J, Webster NJ, Insel PA, Raz E. PMID: 25605931.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    24. Deletion of serine/arginine-rich splicing factor 3 in hepatocytes predisposes to hepatocellular carcinoma in mice. Hepatology. 2015 Jan; 61(1):171-83. Sen S, Langiewicz M, Jumaa H, Webster NJ. PMID: 25132062.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    25. C-Jun N-terminal kinase (JNK) isoforms play differing roles in otitis media. BMC Immunol. 2014 Oct 14; 15:46. Yao W, Frie M, Pan J, Pak K, Webster N, Wasserman SI, Ryan AF. PMID: 25311344.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    26. Omega-3 fatty acids reduce obesity-induced tumor progression independent of GPR120 in a mouse model of postmenopausal breast cancer. Oncogene. 2015 Jul; 34(27):3504-13. Chung H, Lee YS, Mayoral R, Oh DY, Siu JT, Webster NJ, Sears DD, Olefsky JM, Ellies LG. PMID: 25220417.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    27. Molecular tumor board: the University of California-San Diego Moores Cancer Center experience. Oncologist. 2014 Jun; 19(6):631-6. Schwaederle M, Parker BA, Schwab RB, Fanta PT, Boles SG, Daniels GA, Bazhenova LA, Subramanian R, Coutinho AC, Ojeda-Fournier H, Datnow B, Webster NJ, Lippman SM, Kurzrock R. PMID: 24797821.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    28. Free fatty acids induce Lhb mRNA but suppress Fshb mRNA in pituitary LßT2 gonadotropes and diet-induced obesity reduces FSH levels in male mice and disrupts the proestrous LH/FSH surge in female mice. Endocrinology. 2013 Jun; 154(6):2188-99. Sharma S, Morinaga H, Hwang V, Fan W, Fernandez MO, Varki N, Olefsky JM, Webster NJ. PMID: 23525221.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    29. Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function. Nat Commun. 2013; 4:1336. Sen S, Jumaa H, Webster NJ. PMID: 23299886.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    30. Whole genome analysis of Leptospira licerasiae provides insight into leptospiral evolution and pathogenicity. PLoS Negl Trop Dis. 2012; 6(10):e1853. Ricaldi JN, Fouts DE, Selengut JD, Harkins DM, Patra KP, Moreno A, Lehmann JS, Purushe J, Sanka R, Torres M, Webster NJ, Vinetz JM, Matthias MA. PMID: 23145189.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    31. hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene. PLoS One. 2011; 6(11):e27869. Talukdar I, Sen S, Urbano R, Thompson J, Yates JR, Webster NJ. PMID: 22132154.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    32. Cortactin, an actin binding protein, regulates GLUT4 translocation via actin filament remodeling. Biochemistry (Mosc). 2011 Nov; 76(11):1262-9. Nazari H, Khaleghian A, Takahashi A, Harada N, Webster NJ, Nakano M, Kishi K, Ebina Y, Nakaya Y. PMID: 22117553.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    33. Gonadotropin-releasing hormone pulse sensitivity of follicle-stimulating hormone-beta gene is mediated by differential expression of positive regulatory activator protein 1 factors and corepressors SKIL and TGIF1. Mol Endocrinol. 2011 Aug; 25(8):1387-403. Mistry DS, Tsutsumi R, Fernandez M, Sharma S, Cardenas SA, Lawson MA, Webster NJ. PMID: 21659477.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    34. Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHß gene expression by a SirT1-independent pathway in LßT2 gonadotrope cells. Reprod Toxicol. 2011 Jul; 32(1):85-92. Lan D, Lu M, Sharma S, Mellon PL, Olefsky JM, Webster NJ. PMID: 21679764.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    35. Brain PPAR-? promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones. Nat Med. 2011 May; 17(5):618-22. Lu M, Sarruf DA, Talukdar S, Sharma S, Li P, Bandyopadhyay G, Nalbandian S, Fan W, Gayen JR, Mahata SK, Webster NJ, Schwartz MW, Olefsky JM. PMID: 21532596.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    36. Gonadotropin-releasing hormone induces miR-132 and miR-212 to regulate cellular morphology and migration in immortalized LbetaT2 pituitary gonadotrope cells. Mol Endocrinol. 2011 May; 25(5):810-20. Godoy J, Nishimura M, Webster NJ. PMID: 21372146.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    37. The role of DNA sensing and innate immune receptor TLR9 in otitis media. Innate Immun. 2012 Feb; 18(1):3-13. Leichtle A, Hernandez M, Lee J, Pak K, Webster NJ, Wollenberg B, Wasserman SI, Ryan AF. PMID: 21239460.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    38. PPARG regulates gonadotropin-releasing hormone signaling in LbetaT2 cells in vitro and pituitary gonadotroph function in vivo in mice. Biol Reprod. 2011 Mar; 84(3):466-75. Sharma S, Sharma PM, Mistry DS, Chang RJ, Olefsky JM, Mellon PL, Webster NJ. PMID: 21076077.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    39. Modulation of gonadotropin-releasing hormone-induced extracellular signal-regulated kinase activation by dual-specificity protein phosphatase 1 in LbetaT2 gonadotropes. Endocrinology. 2010 Oct; 151(10):4882-93. Nguyen KA, Intriago RE, Upadhyay HC, Santos SJ, Webster NJ, Lawson MA. PMID: 20685880.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    40. Muscleblind-like 1 (Mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer. J Biol Chem. 2010 Aug 13; 285(33):25426-37. Sen S, Talukdar I, Liu Y, Tam J, Reddy S, Webster NJ. PMID: 20519504.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    41. Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10638-43. Datta SK, Sabet M, Nguyen KP, Valdez PA, Gonzalez-Navajas JM, Islam S, Mihajlov I, Fierer J, Insel PA, Webster NJ, Guiney DG, Raz E. PMID: 20479237.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    42. Signaling responses to pulsatile gonadotropin-releasing hormone in LbetaT2 gonadotrope cells. J Biol Chem. 2010 Jun 25; 285(26):20262-72. Tsutsumi R, Mistry D, Webster NJ. PMID: 20406815.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    43. The toll-Like receptor adaptor TRIF contributes to otitis media pathogenesis and recovery. BMC Immunol. 2009 Aug 05; 10:45. Leichtle A, Hernandez M, Pak K, Webster NJ, Wasserman SI, Ryan AF. PMID: 19656404.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    44. GnRH pulsatility, the pituitary response and reproductive dysfunction. Endocr J. 2009; 56(6):729-37. Tsutsumi R, Webster NJ. PMID: 19609045.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimals
    45. TLR4-mediated induction of TLR2 signaling is critical in the pathogenesis and resolution of otitis media. Innate Immun. 2009 Aug; 15(4):205-15. Leichtle A, Hernandez M, Pak K, Yamasaki K, Cheng CF, Webster NJ, Ryan AF, Wasserman SI. PMID: 19586996.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    46. Curcumin disrupts the Mammalian target of rapamycin-raptor complex. Cancer Res. 2009 Feb 01; 69(3):1000-8. Beevers CS, Chen L, Liu L, Luo Y, Webster NJ, Huang S. PMID: 19176385.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    47. Myeloid differentiation primary response gene 88 is required for the resolution of otitis media. J Infect Dis. 2008 Dec 15; 198(12):1862-9. Hernandez M, Leichtle A, Pak K, Ebmeyer J, Euteneuer S, Obonyo M, Guiney DG, Webster NJ, Broide DH, Ryan AF, Wasserman SI. PMID: 18986247.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    48. Small molecule activators of the Trk receptors for neuroprotection. BMC Neurosci. 2008 Dec 03; 9 Suppl 2:S1. Webster NJ, Pirrung MC. PMID: 19090982.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    49. SRp20 and CUG-BP1 modulate insulin receptor exon 11 alternative splicing. Mol Cell Biol. 2009 Feb; 29(3):871-80. Sen S, Talukdar I, Webster NJ. PMID: 19047369.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    50. Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-kappaB/PTEN suppression. J Biol Chem. 2008 Sep 05; 283(36):24889-98. Chandrasekar B, Boylston WH, Venkatachalam K, Webster NJ, Prabhu SD, Valente AJ. PMID: 18632660.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    51. Quinone replacements for small molecule insulin mimics. Chembiochem. 2008 Feb 15; 9(3):360-2. Pirrung MC, Deng L, Lin B, Webster NJ. PMID: 18232038.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    52. Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes. Mol Endocrinol. 2008 Mar; 22(3):760-71. Lu M, Tang Q, Olefsky JM, Mellon PL, Webster NJ. PMID: 18006641.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    53. Identification of novel orally available small molecule insulin mimetics. J Pharmacol Exp Ther. 2007 Nov; 323(2):579-85. Lin B, Li Z, Park K, Deng L, Pai A, Zhong L, Pirrung MC, Webster NJ. PMID: 17687071.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    54. Parallel synthesis of indolylquinones and their cell-based insulin mimicry. J Comb Chem. 2007 Sep-Oct; 9(5):844-54. Pirrung MC, Li Z, Hensley E, Liu Y, Tanksale A, Lin B, Pai A, Webster NJ. PMID: 17595147.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    55. Neuroprotection by small molecule activators of the nerve growth factor receptor. J Pharmacol Exp Ther. 2007 Jul; 322(1):59-69. Lin B, Pirrung MC, Deng L, Li Z, Liu Y, Webster NJ. PMID: 17468299.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    56. Jun N-terminal protein kinase enhances middle ear mucosal proliferation during bacterial otitis media. Infect Immun. 2007 May; 75(5):2562-71. Furukawa M, Ebmeyer J, Pak K, Austin DA, Melhus A, Webster NJ, Ryan AF. PMID: 17325051.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    57. Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2. Mol Endocrinol. 2007 May; 21(5):1175-91. Lawson MA, Tsutsumi R, Zhang H, Talukdar I, Butler BK, Santos SJ, Mellon PL, Webster NJ. PMID: 17299135.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    58. A PI3K pathway mediates hair cell survival and opposes gentamicin toxicity in neonatal rat organ of Corti. J Assoc Res Otolaryngol. 2006 Dec; 7(4):373-82. Chung WH, Pak K, Lin B, Webster N, Ryan AF. PMID: 17053865.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    59. Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing. EMBO J. 2006 Sep 20; 25(18):4271-83. Paul S, Dansithong W, Kim D, Rossi J, Webster NJ, Comai L, Reddy S. PMID: 16946708.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    60. Effect of TRB3 on insulin and nutrient-stimulated hepatic p70 S6 kinase activity. J Biol Chem. 2006 Oct 06; 281(40):29719-29. Matsushima R, Harada N, Webster NJ, Tsutsumi YM, Nakaya Y. PMID: 16887816.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    61. Activin modulates the transcriptional response of LbetaT2 cells to gonadotropin-releasing hormone and alters cellular proliferation. Mol Endocrinol. 2006 Nov; 20(11):2909-30. Zhang H, Bailey JS, Coss D, Lin B, Tsutsumi R, Lawson MA, Mellon PL, Webster NJ. PMID: 16772531.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    62. Amyloid peptides mediate hypoxic increase of L-type Ca2+ channels in central neurones. Neurobiol Aging. 2006 Mar; 27(3):439-45. Webster NJ, Ramsden M, Boyle JP, Pearson HA, Peers C. PMID: 16464656.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    63. Constitutively active Gq impairs gonadotropin-releasing hormone-induced intracellular signaling and luteinizing hormone secretion in LbetaT2 cells. Mol Endocrinol. 2005 Aug; 19(8):2074-85. Liu F, Ruiz MS, Austin DA, Webster NJ. PMID: 15878957.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    64. Methyl scanning: total synthesis of demethylasterriquinone B1 and derivatives for identification of sites of interaction with and isolation of its receptor(s). J Am Chem Soc. 2005 Apr 06; 127(13):4609-24. Pirrung MC, Liu Y, Deng L, Halstead DK, Li Z, May JF, Wedel M, Austin DA, Webster NJ. PMID: 15796526.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    65. Role of p38 mitogen-activated protein kinase in middle ear mucosa hyperplasia during bacterial otitis media. Infect Immun. 2004 Aug; 72(8):4662-7. Palacios SD, Pak K, Rivkin AZ, Kayali AG, Austen D, Aletsee C, Melhus A, Webster NJ, Ryan AF. PMID: 15271927.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    66. Assembly of splicing complexes on exon 11 of the human insulin receptor gene does not correlate with splicing efficiency in-vitro. BMC Mol Biol. 2004 Jul 02; 5:7. Webster NJ, Evans LG, Caples M, Erker L, Chew SL. PMID: 15233842.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    67. Gonadotropin-releasing hormone-desensitized LbetaT2 gonadotrope cells are refractory to acute protein kinase C, cyclic AMP, and calcium-dependent signaling. Endocrinology. 2003 Oct; 144(10):4354-65. Liu F, Austin DA, Webster NJ. PMID: 12960037.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    68. Signaling effects of demethylasterriquinone B1, a selective insulin receptor modulator. Chembiochem. 2003 May 09; 4(5):379-85. Webster NJ, Park K, Pirrung MC. PMID: 12740809.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    69. Participation of Ras and extracellular regulated kinase in the hyperplastic response of middle-ear mucosa during bacterial otitis media. J Infect Dis. 2002 Dec 15; 186(12):1761-9. Palacios SD, Pak K, Kayali AG, Rivkin AZ, Aletsee C, Melhus A, Webster NJ, Ryan AF. PMID: 12447762.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    70. Rottlerin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes by uncoupling mitochondrial oxidative phosphorylation. Endocrinology. 2002 Oct; 143(10):3884-96. Kayali AG, Austin DA, Webster NJ. PMID: 12239100.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    71. Different signaling pathways control acute induction versus long-term repression of LHbeta transcription by GnRH. Endocrinology. 2002 Sep; 143(9):3414-26. Vasilyev VV, Lawson MA, Dipaolo D, Webster NJ, Mellon PL. PMID: 12193554.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    72. PLCgamma participates in insulin stimulation of glucose uptake through activation of PKCzeta in brown adipocytes. Exp Cell Res. 2002 Aug 15; 278(2):146-57. Lorenzo M, Teruel T, Hernandez R, Kayali AG, Webster NJ. PMID: 12169270.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    73. Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells. J Biol Chem. 2002 Aug 30; 277(35):32099-108. Liu F, Usui I, Evans LG, Austin DA, Mellon PL, Olefsky JM, Webster NJ. PMID: 12050161.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    74. Retroviral expression of a kinase-defective IGF-I receptor suppresses growth and causes apoptosis of CHO and U87 cells in-vivo. BMC Cancer. 2002 May 31; 2:15. Seely BL, Samimi G, Webster NJ. PMID: 12057025.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    75. Transcriptional activation of the ovine follicle-stimulating hormone-beta gene by gonadotropin-releasing hormone involves multiple signal transduction pathways. Endocrinology. 2002 May; 143(5):1651-9. Vasilyev VV, Pernasetti F, Rosenberg SB, Barsoum MJ, Austin DA, Webster NJ, Mellon PL. PMID: 11956146.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    76. GnRH activates ERK1/2 leading to the induction of c-fos and LHbeta protein expression in LbetaT2 cells. Mol Endocrinol. 2002 Mar; 16(3):419-34. Liu F, Austin DA, Mellon PL, Olefsky JM, Webster NJ. PMID: 11875099.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    77. PLC-gamma1 enzyme activity is required for insulin-induced DNA synthesis. Endocrinology. 2002 Feb; 143(2):655-64. Eichhorn J, Kayali AG, Resor L, Austin DA, Rose DW, Webster NJ. PMID: 11796522.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    78. Differential effects of unaggregated and aggregated amyloid beta protein (1-40) on K(+) channel currents in primary cultures of rat cerebellar granule and cortical neurones. J Neurochem. 2001 Nov; 79(3):699-712. Ramsden M, Plant LD, Webster NJ, Vaughan PF, Henderson Z, Pearson HA. PMID: 11701773.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    79. Hypoxic enhancement of evoked noradrenaline release from the human neuroblastoma SH-SY5Y. Brain Res Mol Brain Res. 2001 Apr 18; 89(1-2):50-7. Webster NJ, Vaughan PF, Peers C. PMID: 11311975.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    80. Insulin activates phospholipase C-gamma1 via a PI-3 kinase dependent mechanism in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2001 Mar 30; 282(2):615-20. Eichhorn J, Kayali AG, Austin DA, Webster NJ. PMID: 11401505.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    81. Inhibition of depolarisation-evoked [(3)H]noradrenaline release from SH-SYFY human neuroblastoma cells by muscarinic (M1) receptors is not mediated by changes in [Ca(2+)]. Brain Res Mol Brain Res. 2001 Feb 19; 87(1):81-91. Roberts DJ, Khan N, McDonald RL, Webster NJ, Peers C, Vaughan PF. PMID: 11223162.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    82. Stimulation of MAPK cascades by insulin and osmotic shock: lack of an involvement of p38 mitogen-activated protein kinase in glucose transport in 3T3-L1 adipocytes. Diabetes. 2000 Nov; 49(11):1783-93. Kayali AG, Austin DA, Webster NJ. PMID: 11078444.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    83. Induction of insulin resistance in human skeletal muscle cells by downregulation of glycogen synthase protein expression. Metabolism. 2000 Aug; 49(8):962-8. Park KS, Ciaraldi TP, Carter L, Mudaliar S, Nikoulina SE, Webster NJ, Henry RR. PMID: 10954011.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    84. Inhibition of PLC-gamma1 activity converts nerve growth factor from an anti-mitogenic to a mitogenic signal in CHO cells. Oncogene. 1999 Sep 02; 18(35):4908-19. Zapf-Colby A, Eichhorn J, Webster NJ, Olefsky JM. PMID: 10490825.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    85. Hormonal regulation of alternative splicing. Front Horm Res. 1999; 25:1-17. Webster NJ, Huang Z. PMID: 10941399.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    86. Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin. J Biol Chem. 1998 May 29; 273(22):13808-18. Kayali AG, Eichhorn J, Haruta T, Morris AJ, Nelson JG, Vollenweider P, Olefsky JM, Webster NJ. PMID: 9593725.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    87. Identification of intron and exon sequences involved in alternative splicing of insulin receptor pre-mRNA. J Biol Chem. 1998 Apr 24; 273(17):10331-7. Kosaki A, Nelson J, Webster NJ. PMID: 9553088.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    88. Elevated insulin-like growth factor I receptor autophosphorylation and kinase activity in human breast cancer. Cancer Res. 1998 Mar 15; 58(6):1159-64. Resnik JL, Reichart DB, Huey K, Webster NJ, Seely BL. PMID: 9515800.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    89. Differential effects of Wilms tumor WT1 splice variants on the insulin receptor promoter. Biochem Mol Med. 1997 Dec; 62(2):139-50. Webster NJ, Kong Y, Sharma P, Haas M, Sukumar S, Seely BL. PMID: 9441865.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    90. Repression of the insulin receptor promoter by the tumor suppressor gene product p53: a possible mechanism for receptor overexpression in breast cancer. Cancer Res. 1996 Jun 15; 56(12):2781-8. Webster NJ, Resnik JL, Reichart DB, Strauss B, Haas M, Seely BL. PMID: 8665514.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    91. Altered insulin receptor messenger ribonucleic acid splicing in liver is associated with deterioration of glucose tolerance in the spontaneously obese and diabetic rhesus monkey: analysis of controversy between monkey and human studies. J Clin Endocrinol Metab. 1996 Apr; 81(4):1552-6. Huang Z, Bodkin NL, Ortmeyer HK, Zenilman ME, Webster NJ, Hansen BC, Shuldiner AR. PMID: 8636366.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    92. Starvation and refeeding regulate glycogen synthase gene expression in rat liver at the posttranscriptional level. J Nutr. 1995 Oct; 125(10):2457-62. Nur T, Sela I, Webster NJ, Madar Z. PMID: 7562079.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    93. The B isoform of the insulin receptor signals more efficiently than the A isoform in HepG2 cells. J Biol Chem. 1995 Sep 01; 270(35):20816-23. Kosaki A, Pillay TS, Xu L, Webster NJ. PMID: 7657666.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    94. A functional cyclic AMP response element plays a crucial role in neuroendocrine cell type-specific expression of the secretory granule protein chromogranin A. J Clin Invest. 1995 Jul; 96(1):568-78. Wu H, Mahata SK, Mahata M, Webster NJ, Parmer RJ, O'Connor DT. PMID: 7615829.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    95. Cell type-specific gene expression in the neuroendocrine system. A neuroendocrine-specific regulatory element in the promoter of chromogranin A, a ubiquitous secretory granule core protein. J Clin Invest. 1994 Jul; 94(1):118-29. Wu H, Rozansky DJ, Webster NJ, O'Connor DT. PMID: 8040254.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    96. An upstream element from the human insulin receptor gene promoter contains binding sites for C/EBP beta and NF-1. Diabetes. 1994 Feb; 43(2):305-12. Webster NJ, Kong Y, Cameron KE, Resnik JL. PMID: 8288055.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    97. Deletion of exon 21 of the insulin receptor eliminates tyrosine kinase activity but preserves mitogenic signaling. Biochemistry. 1993 Dec 14; 32(49):13545-50. Rolband GC, Williams JF, Webster NJ, Hsu D, Olefsky JM. PMID: 8257690.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    98. Effect of dexamethasone on the alternative splicing of the insulin receptor mRNA and insulin action in HepG2 hepatoma cells. J Biol Chem. 1993 Oct 15; 268(29):21990-6. Kosaki A, Webster NJ. PMID: 8408055.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    99. The insulin receptor C-terminus is involved in regulation of the receptor kinase activity. Biochemistry. 1993 Sep 21; 32(37):9539-44. Kaliman P, Baron V, Alengrin F, Takata Y, Webster NJ, Olefsky JM, Van Obberghen E. PMID: 7690586.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    100. Deletion of the insulin receptor beta-subunit acidic domain results in enhanced metabolic signaling. Endocrinology. 1993 Sep; 133(3):1437-43. Rolband GC, Williams JF, Webster NJ, Olefsky JM. PMID: 8396020.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    101. Relative expression of insulin receptor isoforms does not differ in lean, obese, and noninsulin-dependent diabetes mellitus subjects. J Clin Endocrinol Metab. 1993 May; 76(5):1380-2. Anderson CM, Henry RR, Knudson PE, Olefsky JM, Webster NJ. PMID: 7684396.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    102. Transcriptional regulation of the human insulin receptor promoter. J Biol Chem. 1992 Aug 25; 267(24):17375-83. Cameron KE, Resnik J, Webster NJ. PMID: 1324934.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    103. Intracellular signaling by a mutant human insulin receptor lacking the carboxyl-terminal tyrosine autophosphorylation sites. J Biol Chem. 1992 May 05; 267(13):9065-70. Takata Y, Webster NJ, Olefsky JM. PMID: 1577744.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    104. Mutation of the two carboxyl-terminal tyrosines results in an insulin receptor with normal metabolic signaling but enhanced mitogenic signaling properties. J Biol Chem. 1991 May 15; 266(14):9135-9. Takata Y, Webster NJ, Olefsky JM. PMID: 2026614.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    105. A domain of the insulin receptor required for endocytosis in rat fibroblasts. J Biol Chem. 1990 Jun 15; 265(17):10132-7. Thies RS, Webster NJ, McClain DA. PMID: 2161833.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    106. The human estrogen receptor has two independent nonacidic transcriptional activation functions. Cell. 1989 Nov 03; 59(3):477-87. Tora L, White J, Brou C, Tasset D, Webster N, Scheer E, Chambon P. PMID: 2805068.
      View in: PubMed   Mentions: 262     Fields:    Translation:HumansAnimalsCells
    107. The transcriptional activation function located in the hormone-binding domain of the human oestrogen receptor is not encoded in a single exon. EMBO J. 1989 May; 8(5):1441-6. Webster NJ, Green S, Tasset D, Ponglikitmongkol M, Chambon P. PMID: 2767048.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    108. The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function. Cell. 1988 Jul 15; 54(2):199-207. Webster NJ, Green S, Jin JR, Chambon P. PMID: 3390864.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansCells
    109. The yeast UASG is a transcriptional enhancer in human HeLa cells in the presence of the GAL4 trans-activator. Cell. 1988 Jan 29; 52(2):169-78. Webster N, Jin JR, Green S, Hollis M, Chambon P. PMID: 2830022.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansAnimalsCells
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