Warren Lewis

Title(s)	Assistant Professor In Residence, Ob/Gyn & Reproductive sciences
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

Research Activities and Funding

Glycogen in bacterial Vaginosis & How Carbohydrates Shape the Vaginal Microbiome
NIH R01AI127554Jun 7, 2017 - May 31, 2022
Role: Principal Investigator

Roles of sialidase in G. vaginalis-host interactions during bacterial vaginosis
NIH R01AI114635Dec 1, 2014 - Nov 30, 2024
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Use of Leishmania major parasites expressing a recombinant Trypanosoma cruzi antigen as live vaccines against Chagas disease. Front Microbiol. 2022; 13:1059115. Cai CW, O'Shea A, Eickhoff CS, Guo H, Lewis WG, Beverley SM, Hoft DF. PMID: 36523834; PMCID: PMC9745109.

View in: PubMed Mentions:
Models of Murine Vaginal Colonization by Anaerobically Grown Bacteria. J Vis Exp. 2022 05 25; (183). Morrill SR, Agarwal K, Saha S, Lewis WG, Gilbert NM, Lewis AL. PMID: 35695538; PMCID: PMC9678008.

View in: PubMed Mentions: Fields:
Bio Biology Med Medicine (General)
Translation:Humans Animals Cells
Glycan cross-feeding supports mutualism between Fusobacterium and the vaginal microbiota. PLoS Biol. 2020 08; 18(8):e3000788. Agarwal K, Robinson LS, Aggarwal S, Foster LR, Hernandez-Leyva A, Lin H, Tortelli BA, O'Brien VP, Miller L, Kau AL, Reno H, Gilbert NM, Lewis WG, Lewis AL. PMID: 32841232; PMCID: PMC7447053.

View in: PubMed Mentions: 14 Fields:
Bio Biology
Translation:Humans Animals Cells
Associations between the vaginal microbiome and Candida colonization in women of reproductive age. Am J Obstet Gynecol. 2020 05; 222(5):471.e1-471.e9. Tortelli BA, Lewis WG, Allsworth JE, Member-Meneh N, Foster LR, Reno HE, Peipert JF, Fay JC, Lewis AL. PMID: 31654610; PMCID: PMC7236091.

View in: PubMed Mentions: 20 Fields:
Gyn Gynecology Obs Obstetrics
Translation:Humans Animals Cells
Gardnerella vaginalis and Prevotella bivia Trigger Distinct and Overlapping Phenotypes in a Mouse Model of Bacterial Vaginosis. J Infect Dis. 2019 08 30; 220(7):1099-1108. Gilbert NM, Lewis WG, Li G, Sojka DK, Lubin JB, Lewis AL. PMID: 30715405; PMCID: PMC6736442.

View in: PubMed Mentions: 35 Fields:
Com Communicable Diseases
Translation:Humans Animals Cells
Identification and characterization of NanH2 and NanH3, enzymes responsible for sialidase activity in the vaginal bacterium Gardnerella vaginalis. J Biol Chem. 2019 04 05; 294(14):5230-5245. Robinson LS, Schwebke J, Lewis WG, Lewis AL. PMID: 30723162; PMCID: PMC6462536.

View in: PubMed Mentions: 22 Fields:
Bio Biochemistry
Translation:Humans Cells
Association between obesity and bacterial vaginosis as assessed by Nugent score. Am J Obstet Gynecol. 2019 05; 220(5):476.e1-476.e11. Brookheart RT, Lewis WG, Peipert JF, Lewis AL, Allsworth JE. PMID: 30707966; PMCID: PMC7232937.

View in: PubMed Mentions: 18 Fields:
Gyn Gynecology Obs Obstetrics
Translation:Humans
Relationship between nugent score and vaginal epithelial exfoliation. PLoS One. 2017; 12(5):e0177797. Amegashie CP, Gilbert NM, Peipert JF, Allsworth JE, Lewis WG, Lewis AL. PMID: 28562623; PMCID: PMC5451030.

View in: PubMed Mentions: 20 Fields:
Med Medicine (General)Sci Science
Translation:Humans Cells
The sialate O-acetylesterase EstA from gut Bacteroidetes species enables sialidase-mediated cross-species foraging of 9-O-acetylated sialoglycans. J Biol Chem. 2017 07 14; 292(28):11861-11872. Robinson LS, Lewis WG, Lewis AL. PMID: 28526748; PMCID: PMC5512079.

View in: PubMed Mentions: 24 Fields:
Bio Biochemistry
Translation:Animals Cells
Genome Sequences of 11 Human Vaginal Actinobacteria Strains. Genome Announc. 2016 Sep 29; 4(5). Lewis AL, Deitzler GE, Ruiz MJ, Weimer C, Park S, Robinson LS, Hallsworth-Pepin K, Wollam A, Mitreva M, Lewis WG. PMID: 27688328; PMCID: PMC5043546.

View in: PubMed Mentions: 5
Genome Sequences of 14 Firmicutes Strains Isolated from the Human Vagina. Genome Announc. 2016 Sep 29; 4(5). Deitzler GE, Ruiz MJ, Weimer C, Park S, Robinson L, Hallsworth-Pepin K, Wollam A, Mitreva M, Lewis AL, Lewis WG. PMID: 27688329; PMCID: PMC5043547.

View in: PubMed Mentions: 1
Genome Sequences of 15 Gardnerella vaginalis Strains Isolated from the Vaginas of Women with and without Bacterial Vaginosis. Genome Announc. 2016 Sep 29; 4(5). Robinson LS, Perry J, Lek S, Wollam A, Sodergren E, Weinstock G, Lewis WG, Lewis AL. PMID: 27688326; PMCID: PMC5043544.

View in: PubMed Mentions: 7
Genome Sequences of 12 Bacterial Isolates Obtained from the Urine of Pregnant Women. Genome Announc. 2016 Sep 29; 4(5). Weimer CM, Deitzler GE, Robinson LS, Park S, Hallsworth-Pepin K, Wollam A, Mitreva M, Lewis WG, Lewis AL. PMID: 27688327; PMCID: PMC5043545.

View in: PubMed Mentions: 2
Genome Sequences of Nine Gram-Negative Vaginal Bacterial Isolates. Genome Announc. 2016 Sep 29; 4(5). Deitzler GE, Ruiz MJ, Lu W, Weimer C, Park S, Robinson LS, Hallsworth-Pepin K, Wollam A, Mitreva M, Lewis WG, Lewis AL. PMID: 27688330; PMCID: PMC5043548.

View in: PubMed Mentions: 1
A New Catalog of Microbiological Tools for Women's Infectious Disease Research. Genome Announc. 2016 Sep 29; 4(5). Lewis AL, Lewis WG. PMID: 27688331; PMCID: PMC5043549.

View in: PubMed Mentions:
Discovery and characterization of de novo sialic acid biosynthesis in the phylum Fusobacterium. Glycobiology. 2016 10; 26(10):1107-1119. Lewis AL, Robinson LS, Agarwal K, Lewis WG. PMID: 27613803; PMCID: PMC5072148.

View in: PubMed Mentions: 6 Fields:
Bio Biochemistry
Translation:Cells
Illustrating and homology modeling the proteins of the Zika virus. F1000Res. 2016; 5:275. Ekins S, Liebler J, Neves BJ, Lewis WG, Coffee M, Bienstock R, Southan C, Andrade CH. PMID: 27746901.

View in: PubMed Mentions: 21 Fields:
Sci Science
Host-like carbohydrates promote bloodstream survival of Vibrio vulnificus in vivo. Infect Immun. 2015 Aug; 83(8):3126-36. Lubin JB, Lewis WG, Gilbert NM, Weimer CM, Almagro-Moreno S, Boyd EF, Lewis AL. PMID: 26015477; PMCID: PMC4496609.

View in: PubMed Mentions: 14 Fields:
All Allergy and Immunology Com Communicable Diseases
Translation:Humans Animals Cells
Pan-phylum Comparison of Nematode Metabolic Potential. PLoS Negl Trop Dis. 2015 May; 9(5):e0003788. Tyagi R, Rosa BA, Lewis WG, Mitreva M. PMID: 26000881; PMCID: PMC4441503.

View in: PubMed Mentions: 13 Fields:
Tro Tropical Medicine
Translation:Humans Animals Cells
Enterotoxigenic Escherichia coli secretes a highly conserved mucin-degrading metalloprotease to effectively engage intestinal epithelial cells. Infect Immun. 2014 Feb; 82(2):509-21. Luo Q, Kumar P, Vickers TJ, Sheikh A, Lewis WG, Rasko DA, Sistrunk J, Fleckenstein JM. PMID: 24478067; PMCID: PMC3911403.

View in: PubMed Mentions: 69 Fields:
All Allergy and Immunology Com Communicable Diseases
Translation:Humans Animals Cells
EatA, an immunogenic protective antigen of enterotoxigenic Escherichia coli, degrades intestinal mucin. Infect Immun. 2014 Feb; 82(2):500-8. Kumar P, Luo Q, Vickers TJ, Sheikh A, Lewis WG, Fleckenstein JM. PMID: 24478066; PMCID: PMC3911389.

View in: PubMed Mentions: 62 Fields:
All Allergy and Immunology Com Communicable Diseases
Translation:Humans Animals Cells
Urinary tract infection as a preventable cause of pregnancy complications: opportunities, challenges, and a global call to action. Glob Adv Health Med. 2013 Sep; 2(5):59-69. Gilbert NM, O'Brien VP, Hultgren S, Macones G, Lewis WG, Lewis AL. PMID: 24416696; PMCID: PMC3833562.

View in: PubMed Mentions: 38
Clinical features of bacterial vaginosis in a murine model of vaginal infection with Gardnerella vaginalis. PLoS One. 2013; 8(3):e59539. Gilbert NM, Lewis WG, Lewis AL. PMID: 23527214; PMCID: PMC3602284.

View in: PubMed Mentions: 61 Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals Cells
Degradation, foraging, and depletion of mucus sialoglycans by the vagina-adapted Actinobacterium Gardnerella vaginalis. J Biol Chem. 2013 Apr 26; 288(17):12067-79. Lewis WG, Robinson LS, Gilbert NM, Perry JC, Lewis AL. PMID: 23479734; PMCID: PMC3636892.

View in: PubMed Mentions: 75 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Host sialoglycans and bacterial sialidases: a mucosal perspective. Cell Microbiol. 2012 Aug; 14(8):1174-82. Lewis AL, Lewis WG. PMID: 22519819.

View in: PubMed Mentions: 93 Fields:
Cel Cell Biology Mic Microbiology
Translation:Humans Animals Cells
Hydrolysis of secreted sialoglycoprotein immunoglobulin A (IgA) in ex vivo and biochemical models of bacterial vaginosis. J Biol Chem. 2012 Jan 13; 287(3):2079-89. Lewis WG, Robinson LS, Perry J, Bick JL, Peipert JF, Allsworth JE, Lewis AL. PMID: 22134918; PMCID: PMC3265887.

View in: PubMed Mentions: 31 Fields:
Bio Biochemistry
Translation:Humans Cells
Immune activation and suppression by group B streptococcus in a murine model of urinary tract infection. Infect Immun. 2011 Sep; 79(9):3588-95. Kline KA, Schwartz DJ, Lewis WG, Hultgren SJ, Lewis AL. PMID: 21690238; PMCID: PMC3165466.

View in: PubMed Mentions: 30 Fields:
All Allergy and Immunology Com Communicable Diseases
Translation:Animals Cells
High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIa as a clock regulatory kinase. PLoS Biol. 2010 Dec 14; 8(12):e1000559. Hirota T, Lee JW, Lewis WG, Zhang EE, Breton G, Liu X, Garcia M, Peters EC, Etchegaray JP, Traver D, Schultz PG, Kay SA. PMID: 21179498; PMCID: PMC3001897.

View in: PubMed Mentions: 116 Fields:
Bio Biology
Translation:Humans Animals Cells
A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20746-51. Hirota T, Lewis WG, Liu AC, Lee JW, Schultz PG, Kay SA. PMID: 19104043; PMCID: PMC2606900.

View in: PubMed Mentions: 148 Fields:
Sci Science
Translation:Humans Cells
Mammalian circadian signaling networks and therapeutic targets. Nat Chem Biol. 2007 Oct; 3(10):630-9. Liu AC, Lewis WG, Kay SA. PMID: 17876320.

View in: PubMed Mentions: 71 Fields:
Bio Biology Che Chemistry
Translation:Animals Cells
NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in group B Streptococcus. J Biol Chem. 2007 Sep 21; 282(38):27562-71. Lewis AL, Cao H, Patel SK, Diaz S, Ryan W, Carlin AF, Thon V, Lewis WG, Varki A, Chen X, Nizet V. PMID: 17646166; PMCID: PMC2588433.

View in: PubMed Mentions: 24 Fields:
Bio Biochemistry
Translation:Cells
Accelerated bioorthogonal conjugation: a practical method for the ligation of diverse functional molecules to a polyvalent virus scaffold. Bioconjug Chem. 2005 Nov-Dec; 16(6):1572-9. Sen Gupta S, Kuzelka J, Singh P, Lewis WG, Manchester M, Finn MG. PMID: 16287257.

View in: PubMed Mentions: 70 Fields:
Bio Biochemistry
Translation:Cells
A heteroaryldihydropyrimidine activates and can misdirect hepatitis B virus capsid assembly. Proc Natl Acad Sci U S A. 2005 Jun 07; 102(23):8138-43. Stray SJ, Bourne CR, Punna S, Lewis WG, Finn MG, Zlotnick A. PMID: 15928089; PMCID: PMC1149411.

View in: PubMed Mentions: 115 Fields:
Sci Science
Translation:Cells
Discovery and characterization of catalysts for azide-alkyne cycloaddition by fluorescence quenching. J Am Chem Soc. 2004 Aug 04; 126(30):9152-3. Lewis WG, Magallon FG, Fokin VV, Finn MG. PMID: 15281783.

View in: PubMed Mentions: 61 Fields:
Che Chemistry
Cleavable linkers for porous silicon-based mass spectrometry. Angew Chem Int Ed Engl. 2004 Feb 27; 43(10):1255-60. Meng JC, Averbuj C, Lewis WG, Siuzdak G, Finn MG. PMID: 14991792.

View in: PubMed Mentions: 4 Fields:
Che Chemistry
Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks. Angew Chem Int Ed Engl. 2002 Mar 15; 41(6):1053-7. Lewis WG, Green LG, Grynszpan F, Radic Z, Carlier PR, Taylor P, Finn MG, Sharpless KB. PMID: 12491310.

View in: PubMed Mentions: 136 Fields:
Che Chemistry
Translation:Animals Cells