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Chi-Hua Chen

TitleAssociate Professor
InstitutionUniversity of California San Diego
DepartmentRadiology
Address9500 Gilman Drive #0841
La Jolla CA 92093
Phone858-822-3865
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    Collapse Biography 
    Collapse Education and Training
    University of CambridgePhDDepartment of Psychiatry
    Imperial College LondonMScDepartment of Neuroscience
    National Taiwan UniversityBScDepartment of Pharmacy

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Identifying the Polygenic Basis of the Human Brain and Psychiatric Disorders
    NIH R01MH100351Jul 1, 2013 - Jun 30, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sønderby IE, Gústafsson Ó, Doan NT, Hibar DP, Martin-Brevet S, Westlye LT, Jacquemont S, Djurovic S, Stefánsson H, Stefánsson K, Thompson PM, Andreassen OA. Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia. Mol Psychiatry. 2018 Oct 03. PMID: 30283035.
      View in: PubMed
    2. Chen CM, Chen WL, Hung CT, Lin TH, Chao CY, Lin CH, Wu YR, Chang KH, Yao CF, Lee-Chen GJ, Su MT, Hsieh-Li HM. The indole compound NC009-1 inhibits aggregation and promotes neurite outgrowth through enhancement of HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice. Neurotoxicology. 2018 Jul; 67:259-269. PMID: 29936316.
      View in: PubMed
    3. Sanyal N, Lo MT, Kauppi K, Djurovic S, Andreassen OA, Johnson VE, Chen CH. GWASinlps: Nonlocal prior based iterative SNP selection tool for genome-wide association studies. Bioinformatics. 2018 Jun 19. PMID: 29931045.
      View in: PubMed
    4. Fan CC, Schork AJ, Brown TT, Spencer BE, Akshoomoff N, Chen CH, Kuperman JM, Hagler DJ, Steen VM, Le Hellard S, HÃ¥berg AK, Espeseth T, Andreassen OA, Dale AM, Jernigan TL, Halgren E. Williams Syndrome neuroanatomical score associates with GTF2IRD1 in large-scale magnetic resonance imaging cohorts: a proof of concept for multivariate endophenotypes. Transl Psychiatry. 2018 Jun 08; 8(1):114. PMID: 29884845.
      View in: PubMed
    5. Kauppi K, Fan CC, McEvoy LK, Holland D, Tan CH, Chen CH, Andreassen OA, Desikan RS, Dale AM. Combining Polygenic Hazard Score With Volumetric MRI and Cognitive Measures Improves Prediction of Progression From Mild Cognitive Impairment to Alzheimer's Disease. Front Neurosci. 2018; 12:260. PMID: 29760643.
      View in: PubMed
    6. Schork AJ, Brown TT, Hagler DJ, Thompson WK, Chen CH, Dale AM, Jernigan TL, Akshoomoff N. Polygenic risk for psychiatric disorders correlates with executive function in typical development. Genes Brain Behav. 2018 Apr 16; e12480. PMID: 29660215.
      View in: PubMed
    7. Caussy C, Hsu C, Lo MT, Liu A, Bettencourt R, Ajmera VH, Bassirian S, Hooker J, Sy E, Richards L, Schork N, Schnabl B, Brenner DA, Sirlin CB, Chen CH, Loomba R. Novel link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. Hepatology. 2018 Mar 23. PMID: 29572891.
      View in: PubMed
    8. Fan CC, Smeland OB, Schork AJ, Chen CH, Holland D, Lo MT, Velkur S, Frei O, Jernigan TL, Andreassen OA, Dale AM. Beyond heritability: Improving discoverability in imaging genetics. Hum Mol Genet. 2018 Mar 07. PMID: 29522091.
      View in: PubMed
    9. Kauppi K, Rosenthal SB, Lo MT, Sanyal N, Jiang M, Abagyan R, McEvoy LK, Andreassen OA, Chen CH. Revisiting Antipsychotic Drug Actions Through Gene Networks Associated With Schizophrenia. Am J Psychiatry. 2018 Mar 02; appiajp201717040410. PMID: 29495895.
      View in: PubMed
    10. Chang KH, Lee GC, Huang CC, Kuo HC, Chen CM, Hsiao YC, Hsu HC, Hsu KJ, Lin CH, Chang CW, Lee-Chen GJ, Wu YR. Genetic and functional characters of GRN p.T487I mutation in Taiwanese patients with atypical parkinsonian disorders. Parkinsonism Relat Disord. 2018 Jun; 51:61-66. PMID: 29530724.
      View in: PubMed
    11. Chang KH, Cheng ML, Tang HY, Huang CY, Wu YR, Chen CM. Alternations of Metabolic Profile and Kynurenine Metabolism in the Plasma of Parkinson's Disease. Mol Neurobiol. 2018 Aug; 55(8):6319-6328. PMID: 29294246.
      View in: PubMed
    12. Sanchez-Roige S, Gray JC, MacKillop J, Chen CH, Palmer AA. The genetics of human personality. Genes Brain Behav. 2018 Mar; 17(3):e12439. PMID: 29152902.
      View in: PubMed
    13. Chang KH, Wu YR, Chen CM. Down-regulation of miR-9* in the peripheral leukocytes of Huntington's disease patients. Orphanet J Rare Dis. 2017 12 19; 12(1):185. PMID: 29258536.
      View in: PubMed
    14. Wu HC, Chen CM, Chen YC, Fung HC, Chang KH, Wu YR. DLG2, but not TMEM229B, GPNMB, and ITGA8 polymorphism, is associated with Parkinson's disease in a Taiwanese population. Neurobiol Aging. 2018 04; 64:158.e1-158.e6. PMID: 29290481.
      View in: PubMed
    15. Chen CM, Wu YR, Chang KH. Altered Aconitase 2 Activity in Huntington's Disease Peripheral Blood Cells and Mouse Model Striatum. Int J Mol Sci. 2017 Nov 21; 18(11). PMID: 29160844.
      View in: PubMed
    16. Chen CH, Wang Y, Lo MT, Schork A, Fan CC, Holland D, Kauppi K, Smeland OB, Djurovic S, Sanyal N, Hibar DP, Thompson PM, Thompson WK, Andreassen OA, Dale AM. Leveraging genome characteristics to improve gene discovery for putamen subcortical brain structure. Sci Rep. 2017 Nov 16; 7(1):15736. PMID: 29147026.
      View in: PubMed
    17. Lo MT, Wang Y, Kauppi K, Sanyal N, Fan CC, Smeland OB, Schork A, Holland D, Hinds DA, Tung JY, Andreassen OA, Dale AM, Chen CH. Modeling prior information of common genetic variants improves gene discovery for neuroticism. Hum Mol Genet. 2017 Nov 15; 26(22):4530-4539. PMID: 28973307.
      View in: PubMed
    18. Chang CW, Wu HC, Lyu RK, Lo YS, Chen CM, Ro LS, Chang HS, Huang CC, Liao MF, Wu YR, Kuo HC, Chu CC, Weng YC, Wei PT, Lo AL, Chang KH. Elevated serum levels of endothelin-1 in patients with chronic inflammatory demyelinating polyneuropathy. Clin Chim Acta. 2018 Jan; 476:49-53. PMID: 29137897.
      View in: PubMed
    19. Smeland OB, Wang Y, Frei O, Li W, Hibar DP, Franke B, Bettella F, Witoelar A, Djurovic S, Chen CH, Thompson PM, Dale AM, Andreassen OA. Genetic Overlap Between Schizophrenia and Volumes of Hippocampus, Putamen, and Intracranial Volume Indicates Shared Molecular Genetic Mechanisms. Schizophr Bull. 2017 Nov 09. PMID: 29136250.
      View in: PubMed
    20. Smeland OB, Frei O, Kauppi K, Hill WD, Li W, Wang Y, Krull F, Bettella F, Eriksen JA, Witoelar A, Davies G, Fan CC, Thompson WK, Lam M, Lencz T, Chen CH, Ueland T, Jönsson EG, Djurovic S, Deary IJ, Dale AM, Andreassen OA. Identification of Genetic Loci Jointly Influencing Schizophrenia Risk and the Cognitive Traits of Verbal-Numerical Reasoning, Reaction Time, and General Cognitive Function. JAMA Psychiatry. 2017 Oct 01; 74(10):1065-1075. PMID: 28746715.
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    21. Caussy C, Soni M, Cui J, Bettencourt R, Schork N, Chen CH, Ikhwan MA, Bassirian S, Cepin S, Gonzalez MP, Mendler M, Kono Y, Vodkin I, Mekeel K, Haldorson J, Hemming A, Andrews B, Salotti J, Richards L, Brenner DA, Sirlin CB, Loomba R. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. J Clin Invest. 2017 Jun 30; 127(7):2697-2704. PMID: 28628033.
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    22. Chen IW, Chen CM, Wu YR, Hua MS. Patterns of False Memory in Patients with Huntington's Disease. Arch Clin Neuropsychol. 2017 Jun 01; 32(4):391-400. PMID: 28334378.
      View in: PubMed
    23. Smeland OB, Wang Y, Lo MT, Li W, Frei O, Witoelar A, Tesli M, Hinds DA, Tung JY, Djurovic S, Chen CH, Dale AM, Andreassen OA. Identification of genetic loci shared between schizophrenia and the Big Five personality traits. Sci Rep. 2017 May 22; 7(1):2222. PMID: 28533504.
      View in: PubMed
    24. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C, Bettencourt R, Highlander SK, Jones MB, Sirlin CB, Schnabl B, Brinkac L, Schork N, Chen CH, Brenner DA, Biggs W, Yooseph S, Venter JC, Nelson KE. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Cell Metab. 2017 May 02; 25(5):1054-1062.e5. PMID: 28467925.
      View in: PubMed
    25. Devor A, Andreassen OA, Wang Y, Mäki-Marttunen T, Smeland OB, Fan CC, Schork AJ, Holland D, Thompson WK, Witoelar A, Chen CH, Desikan RS, McEvoy LK, Djurovic S, Greengard P, Svenningsson P, Einevoll GT, Dale AM. Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia. Mol Psychiatry. 2017 Jun; 22(6):792-801. PMID: 28348379.
      View in: PubMed
    26. Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, Karch CM, Bonham LW, Yokoyama JS, Rosen HJ, Miller BL, Dillon WP, Wilson DM, Hess CP, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Hardy J, Goate AM, Hyman BT, Schellenberg GD, McEvoy LK, Andreassen OA, Dale AM. Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. PLoS Med. 2017 Mar; 14(3):e1002258. PMID: 28323831.
      View in: PubMed
    27. Kao YH, Lin MS, Chen CM, Wu YR, Chen HM, Lai HL, Chern Y, Lin CJ. Targeting ENT1 and adenosine tone for the treatment of Huntington's disease. Hum Mol Genet. 2017 02 01; 26(3):467-478. PMID: 28069792.
      View in: PubMed
    28. Foo JN, Tan LC, Irwan ID, Au WL, Low HQ, Prakash KM, Ahmad-Annuar A, Bei J, Chan AY, Chen CM, Chen YC, Chung SJ, Deng H, Lim SY, Mok V, Pang H, Pei Z, Peng R, Shang HF, Song K, Tan AH, Wu YR, Aung T, Cheng CY, Chew FT, Chew SH, Chong SA, Ebstein RP, Lee J, Saw SM, Seow A, Subramaniam M, Tai ES, Vithana EN, Wong TY, Heng KK, Meah WY, Khor CC, Liu H, Zhang F, Liu J, Tan EK. Genome-wide association study of Parkinson's disease in East Asians. Hum Mol Genet. 2017 01 01; 26(1):226-232. PMID: 28011712.
      View in: PubMed
    29. Lo MT, Hinds DA, Tung JY, Franz C, Fan CC, Wang Y, Smeland OB, Schork A, Holland D, Kauppi K, Sanyal N, Escott-Price V, Smith DJ, O'Donovan M, Stefansson H, Bjornsdottir G, Thorgeirsson TE, Stefansson K, McEvoy LK, Dale AM, Andreassen OA, Chen CH. Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders. Nat Genet. 2017 01; 49(1):152-156. PMID: 27918536.
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    30. Newman E, Jernigan TL, Lisdahl KM, Tamm L, Tapert SF, Potkin SG, Mathalon D, Molina B, Bjork J, Castellanos FX, Swanson J, Kuperman JM, Bartsch H, Chen CH, Dale AM, Epstein JN, Group MN. Go/No Go task performance predicts cortical thickness in the caudal inferior frontal gyrus in young adults with and without ADHD. Brain Imaging Behav. 2016 09; 10(3):880-92. PMID: 26404018.
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    31. Chen CM, Chen IC, Chen YL, Lin TH, Chen WL, Chao CY, Wu YR, Lu YT, Lee CY, Chien HC, Chen TS, Lee-Chen GJ, Lee CM. Medicinal herbs Oenanthe javanica (Blume) DC., Casuarina equisetifolia L. and Sorghum bicolor (L.) Moench protect human cells from MPP+ damage via inducing FBXO7 expression. Phytomedicine. 2016 Nov 15; 23(12):1422-1433. PMID: 27765362.
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    32. Peng Q, Schork A, Bartsch H, Lo MT, Panizzon MS. Conservation of Distinct Genetically-Mediated Human Cortical Pattern. PLoS Genet. 2016 07; 12(7):e1006143. PMID: 27459196.
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    33. Braddick O, Atkinson J, Newman E, Akshoomoff N, Kuperman JM, Bartsch H, Chen CH, Dale AM, Jernigan TL. Global Visual Motion Sensitivity: Associations with Parietal Area and Children's Mathematical Cognition. J Cogn Neurosci. 2016 Dec; 28(12):1897-1908. PMID: 27458748.
      View in: PubMed
    34. Peng Q, Schork A, Bartsch H, Lo MT, Panizzon MS, Pediatric Imaging, Neurocognition and Genetics Study, Alzheimer’s Disease Neuroimaging Initiative, Westlye LT, Kremen WS, Jernigan TL, Hellard SL, Steen VM, Espeseth T, Huentelman M, Håberg AK, Agartz I, Djurovic S, Andreassen OA, Dale AM, Schork NJ, and Chen CH.Conservation of distinct genetically-mediated human cortical pattern. PLoS Genet. 2016; 12(7).
    35. Cui J, Chen CH, Lo MT, Schork N, Bettencourt R, Gonzalez MP, Bhatt A, Hooker J, Shaffer K, Nelson KE, Long MT, Brenner DA, Sirlin CB, Loomba R. Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study. Hepatology. 2016 11; 64(5):1547-1558. PMID: 27315352.
      View in: PubMed
    36. Chang KH, Lyu RK, Ro YS, Chen YC, Ro LS, Chang HS, Huang CC, Liao MF, Wu YR, Kuo HC, Chu CC, Chen CM. Increased serum concentrations of transforming growth factor-ß1 (TGF-ß1) in patients with Guillain-Barré syndrome. Clin Chim Acta. 2016 Oct 01; 461:8-13. PMID: 27450064.
      View in: PubMed
    37. Chang KH, Chen CM, Lin CH, Chang WT, Jiang PR, Hsiao YC, Wu YR, Lee-Chen GJ. Functional properties of LRRK2 mutations in Taiwanese Parkinson disease. J Formos Med Assoc. 2017 Mar; 116(3):197-204. PMID: 27423549.
      View in: PubMed
    38. Yokoyama JS, Wang Y, Schork AJ, Thompson WK, Karch CM, Cruchaga C, McEvoy LK, Witoelar A, Chen CH, Holland D, Brewer JB, Franke A, Dillon WP, Wilson DM, Mukherjee P, Hess CP, Miller Z, Bonham LW, Shen J, Rabinovici GD, Rosen HJ, Miller BL, Hyman BT, Schellenberg GD, Karlsen TH, Andreassen OA, Dale AM, Desikan RS. Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease. JAMA Neurol. 2016 Jun 01; 73(6):691-7. PMID: 27088644.
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    39. Chang KH, Chen IC, Lin HY, Chen HC, Lin CH, Lin TH, Weng YT, Chao CY, Wu YR, Lin JY, Lee-Chen GJ, Chen CM. The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer's disease. Drug Des Devel Ther. 2016; 10:885-96. PMID: 27013866; PMCID: PMC4778784.
    40. Holland D, Wang Y, Thompson WK, Schork A, Chen CH, Lo MT, Witoelar A. Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics. Front Genet. 2016; 7:15. PMID: 26909100; PMCID: PMC4754432.
    41. Vuoksimaa E, Panizzon MS, Chen CH, Fiecas M, Eyler LT, Fennema-Notestine C, Hagler DJ, Franz CE, Jak AJ, Lyons MJ, Neale MC, Rinker DA, Thompson WK, Tsuang MT, Dale AM, Kremen WS. Is bigger always better? The importance of cortical configuration with respect to cognitive ability. Neuroimage. 2016 Apr 01; 129:356-366. PMID: 26827810; PMCID: PMC4838639 [Available on 04/01/17].
    42. Wang Y, Thompson WK, Schork AJ, Holland D, Chen CH, Bettella F, Desikan RS, Li W, Witoelar A, Zuber V, Devor A. Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS. PLoS Genet. 2016 Jan; 12(1):e1005803. PMID: 26808560; PMCID: PMC4726519.
    43. Chang KH, Lee-Chen GJ, Wu YR, Chen YJ, Lin JL, Li M, Chen IC, Lo YS, Wu HC, Chen CM. Impairment of proteasome and anti-oxidative pathways in the induced pluripotent stem cell model for sporadic Parkinson's disease. Parkinsonism Relat Disord. 2016 Mar; 24:81-8. PMID: 26797011.
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    44. Lin CH, Wu YR, Yang JM, Chen WL, Chao CY, Chen IC, Lin TH, Wu YC, Hsu KC, Chen CM, Lee GC, Hsieh-Li HM, Lee CM, Lee-Chen GJ. Novel Lactulose and Melibiose Targeting Autophagy to Reduce PolyQ Aggregation in Cell Models of Spinocerebellar Ataxia 3. CNS Neurol Disord Drug Targets. 2016; 15(3):351-9. PMID: 26295831.
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    45. Román FJ, Lewis LB, Chen CH, Karama S, Burgaleta M, Martínez K, Lepage C, Jaeggi SM, Evans AC, Kremen WS, Colom R. Gray matter responsiveness to adaptive working memory training: a surface-based morphometry study. Brain Struct Funct. 2016 12; 221(9):4369-4382. PMID: 26701168.
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    46. Fjell AM, Grydeland H, Krogsrud SK, Amlien I, Rohani DA, Ferschmann L, Storsve AB, Tamnes CK, Sala-Llonch R, Due-Tønnessen P, Bjørnerud A, Sølsnes AE, Håberg AK, Skranes J, Bartsch H, Chen CH, Thompson WK, Panizzon MS, Kremen WS, Dale AM, Walhovd KB. Development and aging of cortical thickness correspond to genetic organization patterns. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15462-7. PMID: 26575625; PMCID: PMC4687601.
    47. Weng YC, Chen CM, Chen YC, Fung HC, Chang CW, Chang KH, Wu YR. Eukaryotic translation initiation factor 4-?, 1 gene mutations are rare in Parkinson's disease among Taiwanese. J Formos Med Assoc. 2016 Sep; 115(9):728-33. PMID: 26490695.
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    48. Chen YC, Huang CJ, Chen P, Wu YR, Shie SS, Chen ST, Lee-Chen GJ, Chen CM. Protein kinase C? polymorphism and the susceptibility to ischemic stroke in the Taiwan population. Biomed J. 2015 Sep-Oct; 38(5):433-8. PMID: 25900926.
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    49. Docherty AR, Sawyers CK, Panizzon MS, Neale MC, Eyler LT, Fennema-Notestine C, Franz CE, Chen CH, McEvoy LK, Verhulst B, Tsuang MT, Kremen WS. Genetic network properties of the human cortex based on regional thickness and surface area measures. Front Hum Neurosci. 2015; 9:440. PMID: 26347632; PMCID: PMC4542323.
    50. Loomba R, Schork N, Chen CH, Bettencourt R, Bhatt A, Ang B, Nguyen P, Hernandez C, Richards L, Salotti J, Lin S, Seki E, Nelson KE, Sirlin CB, Brenner D. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Gastroenterology. 2015 Dec; 149(7):1784-93. PMID: 26299412; PMCID: PMC4663110 [Available on 12/01/16].
    51. Chen CH, Peng Q, Schork AJ, Lo MT, Fan CC, Wang Y, Desikan RS, Bettella F, Hagler DJ. Large-scale genomics unveil polygenic architecture of human cortical surface area. Nat Commun. 2015 Jul 20; 6:7549. PMID: 26189703; PMCID: PMC4518289.
    52. Newman E, Thompson WK, Bartsch H, Hagler DJ, Chen CH, Brown TT, Kuperman JM, McCabe C, Chung Y, Libiger O, Akshoomoff N, Bloss CS, Casey BJ, Chang L, Ernst TM, Frazier JA, Gruen JR, Kennedy DN, Murray SS, Sowell ER, Schork N, Kenet T, Kaufmann WE, Mostofsky S, Amaral DG, Dale AM, Jernigan TL. Anxiety is related to indices of cortical maturation in typically developing children and adolescents. Brain Struct Funct. 2016 07; 221(6):3013-25. PMID: 26183468.
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    53. Fan CC, Bartsch H, Schork AJ, Chen CH, Wang Y, Lo MT, Brown TT, Kuperman JM, Hagler DJ, Schork NJ, Jernigan TL, Dale AM. Modeling the 3D geometry of the cortical surface with genetic ancestry. Curr Biol. 2015 Aug 03; 25(15):1988-92. PMID: 26166778; PMCID: PMC4786069.
    54. Chen CM, Lin YS, Wu YR, Chen P, Tsai FJ, Yang CL, Tsao YT, Chang W, Hsieh IS, Chern Y, Soong BW. High Protein Diet and Huntington's Disease. PLoS One. 2015; 10(5):e0127654. PMID: 25992839; PMCID: PMC4437787.
    55. Desikan RS, Schork AJ, Wang Y, Thompson WK, Dehghan A, Ridker PM, Chasman DI, McEvoy LK, Holland D, Chen CH, Karow DS, Brewer JB, Hess CP, Williams J, Sims R, O'Donovan MC, Choi SH, Bis JC, Ikram MA, Gudnason V, DeStefano AL, van der Lee SJ, Psaty BM, van Duijn CM, Launer L, Seshadri S, Pericak-Vance MA, Mayeux R, Haines JL, Farrer LA, Hardy J, Ulstein ID, Aarsland D, Fladby T, White LR, Sando SB, Rongve A, Witoelar A, Djurovic S, Hyman BT, Snaedal J, Steinberg S, Stefansson H, Stefansson K, Schellenberg GD, Andreassen OA, Dale AM. Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease. Circulation. 2015 Jun 09; 131(23):2061-2069. PMID: 25862742.
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    56. Lee GC, Lin CH, Tao YC, Yang JM, Hsu KC, Huang YJ, Huang SH, Kung PJ, Chen WL, Wang CM, Wu YR, Chen CM, Lin JY, Hsieh-Li HM, Lee-Chen GJ. The potential of lactulose and melibiose, two novel trehalase-indigestible and autophagy-inducing disaccharides, for polyQ-mediated neurodegenerative disease treatment. Neurotoxicology. 2015 May; 48:120-30. PMID: 25800379.
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    57. Desikan RS, Schork AJ, Wang Y, Witoelar A, Sharma M, McEvoy LK, Holland D, Brewer JB, Chen CH, Thompson WK, Harold D, Williams J, Owen MJ, O'Donovan MC, Pericak-Vance MA, Mayeux R, Haines JL, Farrer LA, Schellenberg GD, Heutink P, Singleton AB, Brice A, Wood NW, Hardy J, Martinez M, Choi SH, DeStefano A, Ikram MA, Bis JC, Smith A, Fitzpatrick AL, Launer L, van Duijn C, Seshadri S, Ulstein ID, Aarsland D, Fladby T, Djurovic S, Hyman BT, Snaedal J, Stefansson H, Stefansson K, Gasser T, Andreassen OA, Dale AM. Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus. Mol Psychiatry. 2015 Dec; 20(12):1588-95. PMID: 25687773.
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    58. Hung CH, Chang KH, Chen YL, Wu YM, Lai CL, Chang HS, Lyu RK, Wu YR, Chen CM, Huang CC, Chu CC, Chen CH, Ro LS. Clinical and radiological findings suggesting disorders other than tolosa-hunt syndrome among ophthalmoplegic patients: a retrospective analysis. Headache. 2015 Feb; 55(2):252-64. PMID: 25688645.
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    59. Tsao WC, Lyu RK, Ro LS, Lao MF, Chen CM, Wu YR, Huang CC, Chang HS, Kuo HC, Chu CC, Chang KH. Clinical correlations of motor and somatosensory evoked potentials in neuromyelitis optica. PLoS One. 2014; 9(11):e113631. PMID: 25422930; PMCID: PMC4244088.
    60. Lewis GJ, Panizzon MS, Eyler L, Fennema-Notestine C, Chen CH, Neale MC, Jernigan TL, Lyons MJ, Dale AM, Kremen WS, Franz CE. Heritable influences on amygdala and orbitofrontal cortex contribute to genetic variation in core dimensions of personality. Neuroimage. 2014 Dec; 103:309-315. PMID: 25263286.
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    61. Chang KH, Wu YR, Chen YC, Chen CM. Plasma inflammatory biomarkers for Huntington's disease patients and mouse model. Brain Behav Immun. 2015 Feb; 44:121-7. PMID: 25266150.
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    62. Lin CH, Wu YR, Kung PJ, Chen WL, Lee LC, Lin TH, Chao CY, Chen CM, Chang KH, Janreddy D, Lee-Chen GJ, Yao CF. The potential of indole and a synthetic derivative for polyQ aggregation reduction by enhancement of the chaperone and autophagy systems. ACS Chem Neurosci. 2014 Oct 15; 5(10):1063-74. PMID: 25197952.
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    63. Chen CM, Chen IC, Huang YC, Juan HF, Chen YL, Chen YC, Lin CH, Lee LC, Lee CM, Lee-Chen GJ, Lai YJ, Wu YR. FBXO7 Y52C polymorphism as a potential protective factor in Parkinson's disease. PLoS One. 2014; 9(7):e101392. PMID: 25029497; PMCID: PMC4100735.
    64. Hsiao HY, Chiu FL, Chen CM, Wu YR, Chen HM, Chen YC, Kuo HC, Chern Y. Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease. Hum Mol Genet. 2014 Aug 15; 23(16):4328-44. PMID: 24698979.
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    65. Chen CM, Weng YT, Chen WL, Lin TH, Chao CY, Lin CH, Chen IC, Lee LC, Lin HY, Wu YR, Chen YC, Chang KH, Tang HY, Cheng ML, Lee-Chen GJ, Lin JY. Aqueous extract of Glycyrrhiza inflata inhibits aggregation by upregulating PPARGC1A and NFE2L2-ARE pathways in cell models of spinocerebellar ataxia 3. Free Radic Biol Med. 2014 Jun; 71:339-50. PMID: 24675225.
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    66. Lin CH, Wu YR, Chen WL, Wang HC, Lee CM, Lee-Chen GJ, Chen CM. Variant R244H in Na+/Mg2+ exchanger SLC41A1 in Taiwanese Parkinson's disease is associated with loss of Mg2+ efflux function. Parkinsonism Relat Disord. 2014 Jun; 20(6):600-3. PMID: 24661466.
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    67. Vuoksimaa E, Panizzon MS, Chen CH, Fiecas M, Eyler LT, Fennema-Notestine C, Hagler DJ, Fischl B, Franz CE, Jak A, Lyons MJ, Neale MC, Rinker DA, Thompson WK, Tsuang MT, Dale AM, Kremen WS. The Genetic Association Between Neocortical Volume and General Cognitive Ability Is Driven by Global Surface Area Rather Than Thickness. Cereb Cortex. 2015 Aug; 25(8):2127-37. PMID: 24554725; PMCID: PMC4494025.
    68. Chang KH, Chen WL, Wu YR, Lin TH, Wu YC, Chao CY, Lin JY, Lee LC, Chen YC, Lee-Chen GJ, Chen CM. Aqueous extract of Gardenia jasminoides targeting oxidative stress to reduce polyQ aggregation in cell models of spinocerebellar ataxia 3. Neuropharmacology. 2014 Jun; 81:166-75. PMID: 24486383.
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    69. Lee LC, Weng YT, Wu YR, Soong BW, Tseng YC, Chen CM, Lee-Chen GJ. Downregulation of proteins involved in the endoplasmic reticulum stress response and Nrf2-ARE signaling in lymphoblastoid cells of spinocerebellar ataxia type 17. J Neural Transm (Vienna). 2014 Jun; 121(6):601-10. PMID: 24413982.
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    78. Chang KH, Tseng MY, Ro LS, Lyu RK, Tai YH, Chang HS, Wu YR, Huang CC, Hsu WC, Kuo HC, Chu CC, Chen CM. Analyses of haptoglobin level in the cerebrospinal fluid and serum of patients with neuromyelitis optica and multiple sclerosis. Clin Chim Acta. 2013 Feb 18; 417:26-30. PMID: 23262373.
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    93. Lin CH, Chen CM, Hou YT, Wu YR, Hsieh-Li HM, Su MT, Lee-Chen GJ. The CAG repeat in SCA12 functions as a cis element to up-regulate PPP2R2B expression. Hum Genet. 2010 Aug; 128(2):205-12. PMID: 20533062.
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    95. Huang YC, Fan JY, Ro LS, Lyu RK, Chang HS, Chen ST, Hsu WC, Chen CM, Wu YR. Validation of a Chinese version of disease specific quality of life scale (HFS-36) for hemifacial spasm in Taiwan. Health Qual Life Outcomes. 2009 Dec 24; 7:104. PMID: 20034399; PMCID: PMC2811701.
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    109. Chang KH, Lyu RK, Tseng MY, Ro LS, Wu YR, Chang HS, Hsu WC, Kuo HC, Huang CC, Chu CC, Hsieh SY, Chen CM. Elevated haptoglobin level of cerebrospinal fluid in Guillain-Barré syndrome revealed by proteomics analysis. Proteomics Clin Appl. 2007 May; 1(5):467-75. PMID: 21136698.
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    112. Hammers A, Chen CH, Lemieux L, Allom R, Vossos S, Free SL, Myers R, Brooks DJ, Duncan JS, Koepp MJ. Statistical neuroanatomy of the human inferior frontal gyrus and probabilistic atlas in a standard stereotaxic space. Hum Brain Mapp. 2007 Jan; 28(1):34-48. PMID: 16671082.
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    113. Chang KH, Lyu RK, Ro LS, Wu YR, Chen CM. Coexistence of pernicious anemia and myasthenia gravis--a rare combination of autoimmune diseases in Taiwan. J Formos Med Assoc. 2006 Nov; 105(11):946-9. PMID: 17098697.
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    115. Chen CM, Lane HY, Wu YR, Ro LS, Chen FL, Hung WL, Hou YT, Lin CY, Huang SY, Chen IC, Soong BW, Li ML, Hsieh-Li HM, Su MT, Lee-Chen GJ. Expanded trinucleotide repeats in the TBP/SCA17 gene mapped to chromosome 6q27 are associated with schizophrenia. Schizophr Res. 2005 Oct 15; 78(2-3):131-6. PMID: 16054804.
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    116. Chen CM, Lee-Chen GJ, Wu YR, Lin CY, Chen CJ, Chen IC, Ro LS. Recurrent cerebral venous thrombosis: an Arg359X mutation in the antithrombin gene in a Taiwanese family. Thromb Res. 2006; 118(2):235-40. PMID: 16154182.
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    117. Chen CH, Lennox B, Jacob R, Calder A, Lupson V, Bisbrown-Chippendale R, Suckling J, Bullmore E. Explicit and implicit facial affect recognition in manic and depressed States of bipolar disorder: a functional magnetic resonance imaging study. Biol Psychiatry. 2006 Jan 01; 59(1):31-9. PMID: 16112653.
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    118. Wu YR, Chen CM, Ro LS, Lyu RK, Tang LM. Sensory neuropathy as the initial manifestation of multiple system atrophy. J Formos Med Assoc. 2004 Sep; 103(9):727-30. PMID: 15361949.
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    119. Wang SC, Lee-Chen GJ, Wang CK, Chen CM, Tang LM, Wu YR. Markedly asymmetrical parkinsonism as a leading feature of adult-onset Huntington's disease. Mov Disord. 2004 Jul; 19(7):854-856. PMID: 15254954.
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    120. Wu YR, Lee-Chen GJ, Lang AE, Chen CM, Lin HY, Chen ST. Dystonia as a presenting sign of spinocerebellar ataxia type 1. Mov Disord. 2004 May; 19(5):586-7. PMID: 15133826.
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