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Robert Hoffman

TitleSenate Emeritus
InstitutionUniversity of California San Diego
DepartmentSurgery
Address200 W. Arbor Drive #8220
San Diego CA 92103
Phone858-654-2555
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    Collapse Overview
    Research Overview
    Our research program centers on cancer with the ultimate goal of developing a general cure.

    Research Topics
    - Angiogenesis
    - Cancer
    - Cell Biology
    - Development
    - Drug Delivery
    - Genetics
    - Genomics
    - Regeneration/Stem Cells
    - Translational Research


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    Collapse Research Activities and Funding
    METHIONINE DEPENDENCE, METHYLATION AND ONCOGENESIS
    NIH/NCI K04CA000804Sep 1, 1982 - Aug 31, 1987
    Role: Principal Investigator
    METHIONINE DEPENDENCE, A METABOLIC MARKER IN CANCER
    NIH/NCI R01CA027564Sep 1, 1979 - Nov 30, 1993
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Satake T, Suetsugu A, Nakamura M, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. Color-coded Imaging of the Circulating Tumor Cell Microenvironment. Anticancer Res. 2018 Oct; 38(10):5635-5638. PMID: 30275181.
      View in: PubMed
    2. Higuchi T, Kawaguchi K, Miyake K, Han Q, Tan Y, Oshiro H, Sugisawa N, Zhang Z, Razmjooei S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Chawla SP, Singh AS, Eilber FC, Singh SR, Tsuchiya H, Hoffman RM. Oral Recombinant Methioninase Combined with Caffeine and Doxorubicin Induced Regression of a Doxorubicin-resistant Synovial Sarcoma in a PDOX Mouse Model. Anticancer Res. 2018 Oct; 38(10):5639-5644. PMID: 30275182.
      View in: PubMed
    3. Yuan H, Hu H, Sun J, Shi M, Yu H, Li C, Sun YU, Yang Z, Hoffman RM. Ultrasound Microbubble Delivery Targeting Intraplaque Neovascularization Inhibits Atherosclerotic Plaque in an APOE-deficient Mouse Model. In Vivo. 2018 Sep-Oct; 32(5):1025-1032. PMID: 30150423.
      View in: PubMed
    4. Kawaguchi K, Higuchi T, Li S, Han Q, Tan Y, Igarashi K, Zhao M, Miyake K, Kiyuna T, Miyake M, Ohshiro H, Sugisawa N, Zhang Z, Razmjooei S, Wangsiricharoen S, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Eckardt MA, Singh AS, Singh SR, Eilber FC, Unno M, Hoffman RM. Combination therapy of tumor-targeting Salmonella typhimurium A1-R and oral recombinant methioninase regresses a BRAF-V600E-negative melanoma. Biochem Biophys Res Commun. 2018 Aug 27. PMID: 30166061.
      View in: PubMed
    5. Tome Y, Kiyuna T, Uehara F, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM. Imaging the interaction of av integrin-GFP in osteosarcoma cells with RFP-expressing host stromal cells and tumor-scaffold collagen in the primary and metastatic tumor microenvironment. J Cell Biochem. 2018 Aug 26. PMID: 30145815.
      View in: PubMed
    6. Kiyuna T, Tome Y, Murakami T, Kawaguchi K, Igarashi K, Miyake K, Miyake M, Li Y, Nelson SD, Dry SM, Singh AS, Russell TA, Elliott I, Singh SR, Kanaya F, Eilber FC, Hoffman RM. Trabectedin arrests a doxorubicin-resistant PDGFRA-activated liposarcoma patient-derived orthotopic xenograft (PDOX) nude mouse model. BMC Cancer. 2018 Aug 20; 18(1):840. PMID: 30126369.
      View in: PubMed
    7. Lwin TM, Hoffman RM, Bouvet M. Advantages of patient-derived orthotopic mouse models and genetic reporters for developing fluorescence-guided surgery. J Surg Oncol. 2018 Aug 06. PMID: 30080930.
      View in: PubMed
    8. Forbes NS, Coffin RS, Deng L, Evgin L, Fiering S, Giacalone M, Gravekamp C, Gulley JL, Gunn H, Hoffman RM, Kaur B, Liu K, Lyerly HK, Marciscano AE, Moradian E, Ruppel S, Saltzman DA, Tattersall PJ, Thorne S, Vile RG, Zhang HH, Zhou S, McFadden G. White paper on microbial anti-cancer therapy and prevention. J Immunother Cancer. 2018 Aug 06; 6(1):78. PMID: 30081947.
      View in: PubMed
    9. Dondossola E, Alexander S, Holzapfel BM, Filippini S, Starbuck MW, Hoffman RM, Navone N, De-Juan-Pardo EM, Logothetis CJ, Hutmacher DW, Friedl P. Intravital microscopy of osteolytic progression and therapy response of cancer lesions in the bone. Sci Transl Med. 2018 Aug 01; 10(452). PMID: 30068572.
      View in: PubMed
    10. Nakamura M, Suetsugu A, Hasegawa K, Satake T, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. Color-coded Imaging Distinguishes Cancer Cells, Stromal Cells, and Recombinant Cancer-stromal Cells in the Tumor Microenvironment During Metastasis. Anticancer Res. 2018 Aug; 38(8):4417-4423. PMID: 30061205.
      View in: PubMed
    11. Kawaguchi K, Igarashi K, Miyake K, Kiyuna T, Miyake M, Singh AS, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Unno M, Singh SR, Eilber FC, Hoffman RM. Patterns of Sensitivity to a Panel of Drugs are highly Individualized for Undifferentiated/Unclassified Soft Tissue Sarcoma (USTS) in Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Models. J Drug Target. 2018 Jul 19; 1-25. PMID: 30024282.
      View in: PubMed
    12. Hoffman RM. Human Hair Follicle Associated-Pluripotent (hHAP) Stem Cells Differentiate to Cardiac Muscle Cells. Methods Mol Biol. 2018 Jul 11. PMID: 29992514.
      View in: PubMed
    13. Kawaguchi K, Miyake K, Zhao M, Kiyuna T, Igarashi K, Miyake M, Higuchi T, Oshiro H, Bouvet M, Unno M, Hoffman RM. Tumor targeting Salmonella typhimurium A1-R in combination with gemcitabine (GEM) regresses partially GEM-resistant pancreatic cancer patient-derived orthotopic xenograft (PDOX) nude mouse models. Cell Cycle. 2018 Jul 02. PMID: 29963961.
      View in: PubMed
    14. Kim S, Park SG, Song YJ, Park JK, Choi CH, Lee S, Hoffman RM. Analysis of Anticancer Activity and Chemical Sensitization Effects of Dendropanax morbifera and Commersonia bartramia Extracts. Anticancer Res. 2018 Jul; 38(7):3853-3861. PMID: 29970505.
      View in: PubMed
    15. Kiyuna T, Tome Y, Murakami T, Zhao M, Miyake K, Igarashi K, Kawaguchi K, Miyake M, Oshiro H, Higuchi T, Li Y, Dry SM, Nelson SD, Russell TA, Eckardt MA, Singh AS, Kanaya F, Eilber FC, Hoffman RM. Tumor-targeting Salmonella typhimurium A1-R arrests a doxorubicin-resistant PDGFRA-amplified patient-derived orthotopic xenograft mouse model of pleomorphic liposarcoma. J Cell Biochem. 2018 Jun 22. PMID: 29932244.
      View in: PubMed
    16. Kawaguchi K, Miyake K, Han Q, Li S, Tan Y, Igarashi K, Kiyuna T, Miyake M, Higuchi T, Oshiro H, Zhang Z, Razmjooei S, Wangsiricharoen S, Bouvet M, Singh SR, Unno M, Hoffman RM. Oral recombinant methioninase (o-rMETase) is superior to injectable rMETase and overcomes acquired gemcitabine resistance in pancreatic cancer. Cancer Lett. 2018 Jun 18; 432:251-259. PMID: 29928962.
      View in: PubMed
    17. Millán-Gómez D, Dueñas S, Muñoz PLA, Camacho-Villegas T, Elosua C, Cabanillas-Bernal O, Escalante T, Perona A, Abia D, Drescher F, Fournier PGJ, Ramos MA, Mares RE, Paniagua-Solis J, Mata-Gonzalez T, Gonzalez-Canudas J, Hoffman RM, Licea-Navarro A, Sánchez-Campos N. In silico-designed mutations increase variable new-antigen receptor single-domain antibodies for VEGF165 neutralization. Oncotarget. 2018 Jun 15; 9(46):28016-28029. PMID: 29963259.
      View in: PubMed
    18. Hoffman RM. Erratum: Publisher Correction: Is DNA methylation the new guardian of the genome? Mol Cytogenet. 2018; 11:38. PMID: 29946362.
      View in: PubMed
    19. Miyake K, Kawaguchi K, Miyake M, Zhao M, Kiyuna T, Igarashi K, Zhang Z, Murakami T, Li Y, Nelson SD, Bouvet M, Elliott I, Russell TA, Singh AS, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Singh SR, Endo I, Eilber FC, Hoffman RM. Tumor-targeting Salmonella typhimurium A1-R suppressed an imatinib-resistant gastrointestinal stromal tumor with c-kit exon 11 and 17 mutations. Heliyon. 2018 Jun; 4(6):e00643. PMID: 30003151.
      View in: PubMed
    20. Wang Q, Lu X, Wang J, Yang Z, Hoffman RM, Wu X. Moesin Up-regulation Is Associated with Enhanced Tumor Progression Imaged Non-invasively in an Orthotopic Mouse Model of Human Glioblastoma. Anticancer Res. 2018 Jun; 38(6):3267-3272. PMID: 29848673.
      View in: PubMed
    21. Kiyuna T, Murakami T, Tome Y, Igarashi K, Kawaguchi K, Miyake K, Miyake M, Li Y, Nelson SD, Dry SM, Singh AS, Russell TA, Singh SR, Kanaya F, Eilber FC, Hoffman RM. Doxorubicin-resistant pleomorphic liposarcoma with PDGFRA gene amplification is targeted and regressed by pazopanib in a patient-derived orthotopic xenograft mouse model. Tissue Cell. 2018 Aug; 53:30-36. PMID: 30060824.
      View in: PubMed
    22. Lwin TM, Hoffman RM, Bouvet M. The development of fluorescence guided surgery for pancreatic cancer: from bench to clinic. Expert Rev Anticancer Ther. 2018 May 16. PMID: 29768067.
      View in: PubMed
    23. Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyake M, Li Y, Nelson SD, Dry SM, Singh AS, Elliott IA, Russell TA, Eckardt MA, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. Temozolomide regresses a doxorubicin-resistant undifferentiated spindle-cell sarcoma patient-derived orthotopic xenograft (PDOX): precision-oncology nude-mouse model matching the patient with effective therapy. J Cell Biochem. 2018 May 08. PMID: 29737543.
      View in: PubMed
    24. Kawaguchi K, Igarashi K, Miyake K, Lwin TM, Miyake M, Kiyuna T, Hwang HK, Murakami T, Delong JC, Singh SR, Clary B, Bouvet M, Unno M, Hoffman RM. MEK inhibitor trametinib in combination with gemcitabine regresses a patient-derived orthotopic xenograft (PDOX) pancreatic cancer nude mouse model. Tissue Cell. 2018 Jun; 52:124-128. PMID: 29857821.
      View in: PubMed
    25. Chaturvedi S, Hoffman RM, Bertino JR. Exploiting methionine restriction for cancer treatment. Biochem Pharmacol. 2018 May 04; 154:170-173. PMID: 29733806.
      View in: PubMed
    26. Miyake K, Kiyuna T, Miyake M, Kawaguchi K, Yoon SN, Zhang Z, Igarashi K, Razmjooei S, Wangsiricharoen S, Murakami T, Li Y, Nelson SD, Russell TA, Singh AS, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Singh SR, Endo I, Eilber FC, Hoffman RM. Patient-derived orthotopic xenograft models for cancer of unknown primary precisely distinguish chemotherapy, and tumor-targeting S. typhimurium A1-R is superior to first-line chemotherapy. Signal Transduct Target Ther. 2018; 3:12. PMID: 29713497.
      View in: PubMed
    27. Igarashi K, Kawaguchi K, Li S, Han Q, Tan Y, Gainor E, Kiyuna T, Miyake K, Miyake M, Higuchi T, Oshiro H, Singh AS, Eckardt MA, Nelson SD, Russell TA, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. Recombinant methioninase combined with doxorubicin (DOX) regresses a DOX-resistant synovial sarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model. Oncotarget. 2018 Apr 10; 9(27):19263-19272. PMID: 29721200.
      View in: PubMed
    28. Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyake M, Li S, Han Q, Tan Y, Zhao M, Li Y, Nelson SD, Dry SM, Singh AS, Elliott IA, Russell TA, Eckardt MA, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. Tumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: decoy, trap and kill chemotherapy moves toward the clinic. Cell Cycle. 2018 Apr 10; 1-9. PMID: 29374999.
      View in: PubMed
    29. Kawaguchi K, Miyake K, Han Q, Li S, Tan Y, Igarashi K, Lwin TM, Higuchi T, Kiyuna T, Miyake M, Oshiro H, Bouvet M, Unno M, Hoffman RM. Targeting altered cancer methionine metabolism with recombinant methioninase (rMETase) overcomes partial gemcitabine-resistance and regresses a patient-derived orthotopic xenograft (PDOX) nude mouse model of pancreatic cancer. Cell Cycle. 2018 Apr 06; 1-23. PMID: 29623758.
      View in: PubMed
    30. Suetsugu A, Shimizu M, Saji S, Moriwaki H, Hoffman RM. Visualizing the Tumor Microenvironment by Color-coded Imaging in Orthotopic Mouse Models of Cancer. Anticancer Res. 2018 04; 38(4):1847-1857. PMID: 29599301.
      View in: PubMed
    31. Wang W, Li Y, Chen Y, Chen H, Zhu P, Xu M, Wang H, Wu M, Yang Z, Hoffman RM, Gu Y. Ethanolic Extract of Traditional Chinese Medicine (TCM) Gamboge Inhibits Colon Cancer via the Wnt/Beta-Catenin Signaling Pathway in an Orthotopic Mouse Model. Anticancer Res. 2018 04; 38(4):1917-1925. PMID: 29599307.
      View in: PubMed
    32. Satake T, Suetsugu A, Nakamura M, Hasegawa K, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. Differential Organ-targeting and Cellular Characteristics of Metastatic Human Pancreatic Cancer Cell Lines in Mouse Models. Anticancer Res. 2018 04; 38(4):1927-1935. PMID: 29599308.
      View in: PubMed
    33. Kawaguchi K, Igarashi K, Kiyuna T, Miyake K, Miyake M, Murakami T, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Singh AS, Unno M, Eilber FC, Hoffman RM. Individualized doxorubicin sensitivity testing of undifferentiated soft tissue sarcoma (USTS) in a patient-derived orthotopic xenograft (PDOX) model demonstrates large differences between patients. Cell Cycle. 2018; 17(5):627-633. PMID: 29384032.
      View in: PubMed
    34. Kawaguchi K, Han Q, Li S, Tan Y, Igarashi K, Kiyuna T, Miyake K, Miyake M, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Singh AS, Eckardt MA, Unno M, Eilber FC, Hoffman RM. Targeting methionine with oral recombinant methioninase (o-rMETase) arrests a patient-derived orthotopic xenograft (PDOX) model of BRAF-V600E mutant melanoma: implications for chronic clinical cancer therapy and prevention. Cell Cycle. 2018; 17(3):356-361. PMID: 29187018.
      View in: PubMed
    35. Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyake M, Singh AS, Eckardt MA, Nelson SD, Russell TA, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Singh SR, Eilber FC, Hoffman RM. Tumor-targeting Salmonella typhimurium A1-R is a highly effective general therapeutic for undifferentiated soft tissue sarcoma patient-derived orthotopic xenograft nude-mouse models. Biochem Biophys Res Commun. 2018 03 18; 497(4):1055-1061. PMID: 29481803.
      View in: PubMed
    36. Sato K, Mori R, Hiroshima Y, Oba MS, Matsuyama R, Bouvet M, Hoffman RM, Endo I. RT-PCR of peritoneal washings predicts peritoneal pancreatic cancer recurrence. J Surg Res. 2018 Jun; 226:122-130. PMID: 29661277.
      View in: PubMed
    37. Wang J, Yang X, Han H, Wang L, Bao W, Wang S, Hoffman RM, Yang M, Qi H, An C, Hu K. Inhibition of growth and metastasis of triple-negative breast cancer targeted by Traditional Chinese Medicine Tubeimu in orthotopic mice models. Chin J Cancer Res. 2018 Feb; 30(1):112-121. PMID: 29545725.
      View in: PubMed
    38. Hwang HK, Kang CM, Lee SH, Murakami T, Kiyuna T, Kim SH, Hoffman RM, Bouvet M. Fluorescence-guided Surgery with Splenic Preservation Prevents Tumor Recurrence in an Orthotopic Nude-mouse Model of Human Pancreatic Cancer. Anticancer Res. 2018 02; 38(2):665-670. PMID: 29374688.
      View in: PubMed
    39. Lwin TM, Murakami T, Miyake K, Yazaki PJ, Shivley JE, Hoffman RM, Bouvet M. Tumor-Specific Labeling of Pancreatic Cancer Using a Humanized Anti-CEA Antibody Conjugated to a Near-Infrared Fluorophore. Ann Surg Oncol. 2018 Apr; 25(4):1079-1085. PMID: 29372363.
      View in: PubMed
    40. Kramer MG, Masner M, Ferreira FA, Hoffman RM. Bacterial Therapy of Cancer: Promises, Limitations, and Insights for Future Directions. Front Microbiol. 2018; 9:16. PMID: 29472896.
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    41. Kawaguchi K, Han Q, Li S, Tan Y, Igarashi K, Miyake K, Kiyuna T, Miyake M, Chemielwski B, Nelson SD, Russell TA, Dry SM, Li Y, Singh AS, Eckardt MA, Unno M, Eilber FC, Hoffman RM. Intra-tumor L-methionine level highly correlates with tumor size in both pancreatic cancer and melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse models. Oncotarget. 2018 Feb 16; 9(13):11119-11125. PMID: 29541401.
      View in: PubMed
    42. Miyake K, Kawaguchi K, Kiyuna T, Miyake M, Igarashi K, Zhang Z, Murakami T, Li Y, Nelson SD, Elliott I, Russell T, Singh A, Hiroshima Y, Momiyama M, Matsuyama R, Chisima T, Endo I, Eilber FC, Hoffman RM. Regorafenib regresses an imatinib-resistant recurrent gastrointestinal stromal tumor (GIST) with a mutation in exons 11 and 17 in a patient-derived orthotopic xenograft (PDOX) nude mouse model. Cell Cycle. 2018 Jan 15; 1-21. PMID: 29334307.
      View in: PubMed
    43. Kim SR, Yi HJ, Lee YN, Park JY, Hoffman RM, Okano T, Shim IK, Kim SC. Engineered mesenchymal stem-cell-sheets patches prevents postoperative pancreatic leakage in a rat model. Sci Rep. 2018 Jan 10; 8(1):360. PMID: 29321630.
      View in: PubMed
    44. Igarashi K, Kawaguchi K, Li S, Han Q, Tan Y, Murakami T, Kiyuna T, Miyake K, Miyake M, Singh AS, Eckardt MA, Nelson SD, Russell TA, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Singh SR, Eilber FC, Hoffman RM. Recombinant methioninase in combination with doxorubicin (DOX) overcomes first-line DOX resistance in a patient-derived orthotopic xenograft nude-mouse model of undifferentiated spindle-cell sarcoma. Cancer Lett. 2018 Mar 28; 417:168-173. PMID: 29306021.
      View in: PubMed
    45. Igarashi K, Li S, Han Q, Tan Y, Kawaguchi K, Murakami T, Kiyuna T, Miyake K, Li Y, Nelson SD, Dry SM, Singh AS, Elliott IA, Russell TA, Eckardt MA, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. Growth of doxorubicin-resistant undifferentiated spindle-cell sarcoma PDOX is arrested by metabolic targeting with recombinant methioninase. J Cell Biochem. 2018 Apr; 119(4):3537-3544. PMID: 29143983.
      View in: PubMed
    46. Fang T, Huang H, Li X, Liao J, Yang Z, Hoffman RM, Cheng XI, Liang L, Hu W, Yun S. Effects of siRNA Silencing of TUG1 and LCAL6 Long Non-coding RNAs on Patient-derived Xenograft of Non-small Cell Lung Cancer. Anticancer Res. 2018 01; 38(1):179-186. PMID: 29277771.
      View in: PubMed
    47. Hoffman RM. 3D Sponge-Matrix Histoculture: An Overview. Methods Mol Biol. 2018; 1760:11-17. PMID: 29572789.
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    48. Hoffman RM. Clinical Correlation of the Histoculture Drug Response Assay in Gastrointestinal Cancer. Methods Mol Biol. 2018; 1760:61-72. PMID: 29572794.
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    49. Hoffman RM. Clinical Correlation of the Histoculture Drug Response Assay for Head and Neck Cancer. Methods Mol Biol. 2018; 1760:83-92. PMID: 29572796.
      View in: PubMed
    50. Hoffman RM, Mii S, Duong J, Amoh Y. Nerve Growth and Interaction in Gelfoam® Histoculture: A Nervous System Organoid. Methods Mol Biol. 2018; 1760:163-186. PMID: 29572803.
      View in: PubMed
    51. Miwa S, Hoffman RM. Imaging DNA Repair After UV Irradiation Damage of Cancer Cells in Gelfoam® Histoculture. Methods Mol Biol. 2018; 1760:199-203. PMID: 29572805.
      View in: PubMed
    52. Hoffman RM. Clinical Usefulness of the Histoculture Drug Response Assay for Prostate Cancer and Benign Prostate Hypertrophy (BPH). Methods Mol Biol. 2018; 1760:101-107. PMID: 29572798.
      View in: PubMed
    53. Hoffman RM, Yano S. In Vivo-Like Cell-Cycle Phase Distribution of Cancer Cells in Gelfoam® Histoculture Observed in Real Time by FUCCI Imaging. Methods Mol Biol. 2018; 1760:109-123. PMID: 29572799.
      View in: PubMed
    54. Hoffman RM. Methionine Dependency Determination of Human Patient Tumors in Gelfoam® Histoculture. Methods Mol Biol. 2018; 1760:125-131. PMID: 29572800.
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    55. Hoffman RM, Li L, Cao W. Hair-Shaft Growth in Gelfoam® Histoculture of Skin and Isolated Hair Follicles. Methods Mol Biol. 2018; 1760:133-144. PMID: 29572801.
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    56. Liu F, Hoffman RM. Hair Follicle-Associated Pluripotent (HAP) Stem Cells in Gelfoam® Histoculture for Use in Spinal Cord Repair. Methods Mol Biol. 2018; 1760:145-162. PMID: 29572802.
      View in: PubMed
    57. Yang G, Qiu J, Wang D, Tao Y, Song Y, Wang H, Tang J, Wang X, Sun YU, Yang Z, Hoffman RM. Traditional Chinese Medicine Curcumin Sensitizes Human Colon Cancer to Radiation by Altering the Expression of DNA Repair-related Genes. Anticancer Res. 2018 01; 38(1):131-136. PMID: 29277765.
      View in: PubMed
    58. Kiyuna T, Tome Y, Uehara F, Murakami T, Zhang Y, Zhao M, Kanaya F, Hoffman RM. Tumor-targeting Salmonella typhimurium A1-R Inhibits Osteosarcoma Angiogenesis in the In Vivo Gelfoam® Assay Visualized by Color-coded Imaging. Anticancer Res. 2018 01; 38(1):159-164. PMID: 29277768.
      View in: PubMed
    59. Hoffman RM, Freeman AE. In Vivo-Like Growth Patterns of Multiple Types of Tumors in Gelfoam® Histoculture. Methods Mol Biol. 2018; 1760:19-28. PMID: 29572790.
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    60. Hoffman RM, Guadagni F. Expression and Targeting of Tumor Markers in Gelfoam® Histoculture: Potential Individualized Assays for Immuno-Oncology. Methods Mol Biol. 2018; 1760:29-37. PMID: 29572791.
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    61. Hoffman RM, Vescio RA. Development of the Histoculture Drug Response Assay (HDRA). Methods Mol Biol. 2018; 1760:39-48. PMID: 29572792.
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    62. Hoffman RM. Diagnosis and Pathological Analysis of Patient Cancers by Detection of Proliferating Cells in Gelfoam® Histoculture. Methods Mol Biol. 2018; 1760:49-60. PMID: 29572793.
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    63. Hoffman RM, Chishima T. Imaging the Governing Step of Metastasis in Gelfoam® Histoculture. Methods Mol Biol. 2018; 1760:215-220. PMID: 29572807.
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    64. Hoffman RM, Jung PS, Kim MB, Nam JH. Prospective Clinical Correlation of the Histoculture Drug Response Assay for Ovarian Cancer. Methods Mol Biol. 2018; 1760:73-81. PMID: 29572795.
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    65. Hoffman RM, Tanino H. Clinical Usefulness of the Histoculture Drug Response Assay for Breast Cancer. Methods Mol Biol. 2018; 1760:93-100. PMID: 29572797.
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    66. Tome Y, Uehara F, Kanaya F, Hoffman RM. Comparison of "Dimensionality" of Cancer Cell Culture in Gelfoam® Histoculture and Matrigel. Methods Mol Biol. 2018; 1760:205-214. PMID: 29572806.
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    67. Hoffman RM, Amoh Y. Beating Heart Cells from Hair-Follicle-Associated Pluripotent (HAP) Stem Cells. Methods Mol Biol. 2018; 1842:241-254. PMID: 30196415.
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    68. Jun E, Hong SM, Yoo HJ, Kim MB, Won JS, An S, Shim IK, Chang S, Hoffman RM, Kim SC. Genetic and metabolic comparison of orthotopic and heterotopic patient-derived pancreatic-cancer xenografts to the original patient tumors. Oncotarget. 2018 Jan 30; 9(8):7867-7881. PMID: 29487698.
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    69. Kawaguchi K, Igarashi K, Li S, Han Q, Tan Y, Miyake K, Kiyuna T, Miyake M, Murakami T, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Unno M, Eilber FC, Hoffman RM. Recombinant methioninase (rMETase) is an effective therapeutic for BRAF-V600E-negative as well as -positive melanoma in patient-derived orthotopic xenograft (PDOX) mouse models. Oncotarget. 2018 Jan 02; 9(1):915-923. PMID: 29416666.
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    70. Primack BA, Shensa A, Sidani JE, Hoffman BL, Soneji S, Sargent JD, Hoffman RM, Fine MJ. Initiation of Traditional Cigarette Smoking after Electronic Cigarette Use Among Tobacco-Naïve US Young Adults. Am J Med. 2018 Apr; 131(4):443.e1-443.e9. PMID: 29242110.
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    71. Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyake M, Li Y, Nelson SD, Dry SM, Singh AS, Elliott IA, Russell TA, Eckardt MA, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. Temozolomide combined with irinotecan regresses a cisplatinum-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) precision-oncology mouse model. Oncotarget. 2018 Jan 30; 9(8):7774-7781. PMID: 29487690.
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    72. DeLong JC, Murakami T, Yazaki PJ, Hoffman RM, Bouvet M. Near-infrared-conjugated humanized anti-carcinoembryonic antigen antibody targets colon cancer in an orthotopic nude-mouse model. J Surg Res. 2017 Oct; 218:139-143. PMID: 28985840.
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    73. Hwang HK, Murakami T, Kiyuna T, Kim SH, Lee SH, Kang CM, Hoffman RM, Bouvet M. Splenectomy is associated with an aggressive tumor growth pattern and altered host immunity in an orthotopic syngeneic murine pancreatic cancer model. Oncotarget. 2017 Oct 24; 8(51):88827-88834. PMID: 29179479.
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    74. Miyake K, Murakami T, Kiyuna T, Igarashi K, Kawaguchi K, Li Y, Singh AS, Dry SM, Eckardt MA, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Endo I, Eilber FC, Hoffman RM. Eribulin regresses a doxorubicin-resistant Ewing's sarcoma with a FUS-ERG fusion and CDKN2A-deletion in a patient-derived orthotopic xenograft (PDOX) nude mouse model. J Cell Biochem. 2018 Jan; 119(1):967-972. PMID: 28681998.
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    75. Lwin TM, Hoffman RM, Bouvet M. Regarding the applications of fusion-fluorescence imaging using indocyanine green in laparoscopic hepatectomy. Transl Gastroenterol Hepatol. 2017; 2:70. PMID: 29034343.
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    76. Yamazaki A, Obara K, Tohgi N, Shirai K, Mii S, Hamada Y, Arakawa N, Aki R, Hoffman RM, Amoh Y. Implanted hair-follicle-associated pluripotent (HAP) stem cells encapsulated in polyvinylidene fluoride membrane cylinders promote effective recovery of peripheral nerve injury. Cell Cycle. 2017 Oct 18; 16(20):1927-1932. PMID: 28886268.
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    77. Miyake K, Murakami T, Kiyuna T, Igarashi K, Kawaguchi K, Miyake M, Li Y, Nelson SD, Dry SM, Bouvet M, Elliott IA, Russell TA, Singh AS, Eckardt MA, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Endo I, Eilber FC, Hoffman RM. The combination of temozolomide-irinotecan regresses a doxorubicin-resistant patient-derived orthotopic xenograft (PDOX) nude-mouse model of recurrent Ewing's sarcoma with a FUS-ERG fusion and CDKN2A deletion: Direction for third-line patient therapy. Oncotarget. 2017 Nov 28; 8(61):103129-103136. PMID: 29262551.
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    78. Amoh Y, Hoffman RM. Hair follicle-associated-pluripotent (HAP) stem cells. Cell Cycle. 2017; 16(22):2169-2175. PMID: 28749199.
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    79. Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Murakami T, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Hoffman RM. Effective Metabolic Targeting of Human Osteosarcoma Cells In Vitro and in Orthotopic Nude-mouse Models with Recombinant Methioninase. Anticancer Res. 2017 09; 37(9):4807-4812. PMID: 28870899.
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    80. Hoffman RM. Patient-Derived Orthotopic Xenograft (PDOX) Models of Melanoma. Int J Mol Sci. 2017 Aug 31; 18(9). PMID: 28858204.
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    81. Kawaguchi K, Igarashi K, Li S, Han Q, Tan Y, Kiyuna T, Miyake K, Murakami T, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Unno M, Eilber FC, Hoffman RM. Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model. Oncotarget. 2017 Oct 17; 8(49):85516-85525. PMID: 29156737.
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    82. Murakami T, Hiroshima Y, Zhang Y, Zhao M, Kiyuna T, Hwang HK, Miyake K, Homma Y, Mori R, Matsuyama R, Chishima T, Ichikawa Y, Tanaka K, Bouvet M, Endo I, Hoffman RM. Tumor-Targeting Salmonella typhimurium A1-R Promotes Tumoricidal CD8+ T Cell Tumor Infiltration and Arrests Growth and Metastasis in a Syngeneic Pancreatic-Cancer Orthotopic Mouse Model. J Cell Biochem. 2018 Jan; 119(1):634-639. PMID: 28628234.
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    83. Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Miwa S, Nelson SD, Dry SM, Li Y, Singh AS, Kimura H, Hayashi K, Yamamoto N, Tsuchiya H, Eilber FC, Hoffman RM. Efficacy In Vitro of Caffeine and Valproic Acid on Patient-Derived Undifferentiated Pleomorphic Sarcoma and Rhabdomyosarcoma Cell Lines. Anticancer Res. 2017 08; 37(8):4081-4084. PMID: 28739691.
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    84. Zhang W, Yin G, Dai J, Sun YU, Hoffman RM, Yang Z, Fan Y. Chemoprevention by Quercetin of Oral Squamous Cell Carcinoma by Suppression of the NF-?B Signaling Pathway in DMBA-treated Hamsters. Anticancer Res. 2017 08; 37(8):4041-4049. PMID: 28739686.
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    85. Yano S, Takehara K, Tazawa H, Kishimoto H, Urata Y, Kagawa S, Fujiwara T, Hoffman RM. Therapeutic Cell-Cycle-Decoy Efficacy of a Telomerase-Dependent Adenovirus in an Orthotopic Model of Chemotherapy-Resistant Human Stomach Carcinomatosis Peritonitis Visualized With FUCCI Imaging. J Cell Biochem. 2017 11; 118(11):3635-3642. PMID: 27171483.
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    86. Kawaguchi K, Igarashi K, Murakami T, Kiyuna T, Lwin TM, Hwang HK, Delong JC, Clary BM, Bouvet M, Unno M, Hoffman RM. MEK inhibitors cobimetinib and trametinib, regressed a gemcitabine-resistant pancreatic-cancer patient-derived orthotopic xenograft (PDOX). Oncotarget. 2017 Jul 18; 8(29):47490-47496. PMID: 28537897.
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    87. Igarashi K, Murakami T, Kawaguchi K, Kiyuna T, Miyake K, Zhang Y, Nelson SD, Dry SM, Li Y, Yanagawa J, Russell TA, Singh AS, Tsuchiya H, Elliott I, Eilber FC, Hoffman RM. A patient-derived orthotopic xenograft (PDOX) mouse model of a cisplatinum-resistant osteosarcoma lung metastasis that was sensitive to temozolomide and trabectedin: implications for precision oncology. Oncotarget. 2017 Sep 22; 8(37):62111-62119. PMID: 28977930.
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    88. Slominski AT, Brozyna AA, Skobowiat C, Zmijewski MA, Kim TK, Janjetovic Z, Oak AS, Jozwicki W, Jetten AM, Mason RS, Elmets C, Li W, Hoffman RM, Tuckey RC. On the role of classical and novel forms of vitamin D in melanoma progression and management. J Steroid Biochem Mol Biol. 2018 Mar; 177:159-170. PMID: 28676457.
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    89. Nakamura M, Suetsugu A, Hasegawa K, Matsumoto T, Aoki H, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. Choline-Deficient-Diet-Induced Fatty Liver Is a Metastasis-Resistant Microenvironment. Anticancer Res. 2017 07; 37(7):3429-3434. PMID: 28668831.
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    90. Hasegawa K, Suetsugu A, Nakamura M, Matsumoto T, Aoki H, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. Imaging the Role of Multinucleate Pancreatic Cancer Cells and Cancer-Associated Fibroblasts in Peritoneal Metastasis in Mouse Models. Anticancer Res. 2017 07; 37(7):3435-3440. PMID: 28668832.
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    91. Xu X, Li X, Zhang L, Liu Z, Pan Y, Chen D, Bin D, Deng Q, Sun YU, Hoffman RM, Yang Z, Yuan H. Enhancement of Wound Healing by the Traditional Chinese Medicine Herbal Mixture Sophora flavescens in a Rat Model of Perianal Ulceration. In Vivo. 2017 Jul-Aug; 31(4):543-549. PMID: 28652418.
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    92. Igarashi K, Kawaguchi K, Murakami T, Kiyuna T, Miyake K, Yamamoto N, Hayashi K, Kimura H, Nelson SD, Dry SM, Li Y, Singh AS, Miwa S, Odani A, Eilber FC, Tsuchiya H, Hoffman RM. A novel anionic-phosphate-platinum complex effectively targets an undifferentiated pleomorphic sarcoma better than cisplatinum and doxorubicin in a patient-derived orthotopic xenograft (PDOX). Oncotarget. 2017 Sep 08; 8(38):63353-63359. PMID: 28968995.
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    93. Yu Z, Zhao S, Ren L, Wang L, Chen Z, Hoffman RM, Zhou J. Pancreatic cancer-derived exosomes promote tumor metastasis and liver pre-metastatic niche formation. Oncotarget. 2017 Sep 08; 8(38):63461-63483. PMID: 28969005.
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    94. Shim IK, Yi HJ, Yi HG, Lee CM, Lee YN, Choi YJ, Jeong SY, Jun E, Hoffman RM, Cho DW, Kim SC. Locally-applied 5-fluorouracil-loaded slow-release patch prevents pancreatic cancer growth in an orthotopic mouse model. Oncotarget. 2017 Jun 20; 8(25):40140-40151. PMID: 28498800.
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    95. Kawaguchi K, Igarashi K, Murakami T, Kiyuna T, Zhao M, Zhang Y, Nelson SD, Russell TA, Dry SM, Singh AS, Chmielowski B, Li Y, Unno M, Eilber FC, Hoffman RM. Salmonella typhimurium A1-R targeting of a chemotherapy-resistant BRAF-V600E melanoma in a patient-derived orthotopic xenograft (PDOX) model is enhanced in combination with either vemurafenib or temozolomide. Cell Cycle. 2017 Jul 03; 16(13):1288-1294. PMID: 28622068.
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    96. Murakami T, Homma Y, Matsuyama R, Mori R, Miyake K, Tanaka Y, Den K, Nagashima Y, Nakazawa M, Hiroshima Y, Ueda M, Tanaka K, Hoffman RM, Bouvet M, Endo I. Neoadjuvant chemoradiotherapy of pancreatic cancer induces a favorable immunogenic tumor microenvironment associated with increased major histocompatibility complex class I-related chain A/B expression. J Surg Oncol. 2017 Sep; 116(3):416-426. PMID: 28608409.
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    97. Nakamura M, Suetsugu A, Hasegawa K, Matsumoto T, Aoki H, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. Genetic Recombination Between Stromal and Cancer Cells Results in Highly Malignant Cells Identified by Color-Coded Imaging in a Mouse Lymphoma Model. J Cell Biochem. 2017 Dec; 118(12):4216-4221. PMID: 28419513.
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    98. Murakami T, Li S, Han Q, Tan Y, Kiyuna T, Igarashi K, Kawaguchi K, Hwang HK, Miyake K, Singh AS, Nelson SD, Dry SM, Li Y, Hiroshima Y, Lwin TM, DeLong JC, Chishima T, Tanaka K, Bouvet M, Endo I, Eilber FC, Hoffman RM. Recombinant methioninase effectively targets a Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model. Oncotarget. 2017 May 30; 8(22):35630-35638. PMID: 28404944.
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    99. Hoffman RM. Strategies for In Vivo Imaging Using Fluorescent Proteins. J Cell Biochem. 2017 09; 118(9):2571-2580. PMID: 27564860.
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    100. Kiyuna T, Murakami T, Tome Y, Kawaguchi K, Igarashi K, Miyake K, Kanaya F, Singh A, Eilber FC, Hoffman RM. Analysis of Stroma Labeling During Multiple Passage of a Sarcoma Imageable Patient-Derived Orthotopic Xenograft (iPDOX) in Red Fluorescent Protein Transgenic Nude Mice. J Cell Biochem. 2017 10; 118(10):3367-3371. PMID: 28300287.
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    101. Igarashi K, Kawaguchi K, Murakami T, Kiyuna T, Miyake K, Nelson SD, Dry SM, Li Y, Yanagawa J, Russell TA, Singh AS, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. Intra-arterial administration of tumor-targeting Salmonella typhimurium A1-R regresses a cisplatin-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model. Cell Cycle. 2017 Jun 18; 16(12):1164-1170. PMID: 28494180.
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    102. Zhang Y, Cao W, Toneri M, Zhang N, Kiyuna T, Murakami T, Nelson SD, Dry SM, Li Y, Li S, Wang X, Ma H, Singh AS, Eilber FC, Hoffman RM, Zhao M. Toxicology and efficacy of tumor-targeting Salmonella typhimurium A1-R compared to VNP 20009 in a syngeneic mouse tumor model in immunocompetent mice. Oncotarget. 2017 Aug 15; 8(33):54616-54628. PMID: 28903369.
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    103. Wang Q, Lu X, Zhao S, Pang M, Wu X, Wu H, Hoffman RM, Yang Z, Zhang Y. Moesin Expression Is Associated with Glioblastoma Cell Proliferation and Invasion. Anticancer Res. 2017 05; 37(5):2211-2218. PMID: 28476784.
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    104. Igarashi K, Kawaguchi K, Murakami T, Kiyuna T, Miyake K, Singh AS, Nelson SD, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. High Efficacy of Pazopanib on an Undifferentiated Spindle-Cell Sarcoma Resistant to First-Line Therapy Is Identified With a Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model. J Cell Biochem. 2017 09; 118(9):2739-2743. PMID: 28176365.
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    105. Kawaguchi K, Igarashi K, Murakami T, Zhao M, Zhang Y, Chmielowski B, Kiyuna T, Nelson SD, Russell TA, Dry SM, Li Y, Unno M, Eilber FC, Hoffman RM. Tumor-Targeting Salmonella typhimurium A1-R Sensitizes Melanoma With a BRAF-V600E Mutation to Vemurafenib in a Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model. J Cell Biochem. 2017 08; 118(8):2314-2319. PMID: 28106277.
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    106. Murakami T, Hiroshima Y, Miyake K, Hwang HK, Kiyuna T, DeLong JC, Lwin TM, Matsuyama R, Mori R, Kumamoto T, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM. Color-coded intravital imaging demonstrates a transforming growth factor-ß (TGF-ß) antagonist selectively targets stromal cells in a human pancreatic-cancer orthotopic mouse model. Cell Cycle. 2017 May 19; 16(10):1008-1014. PMID: 28441080.
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    107. Kawaguchi K, Igarashi K, Murakami T, Kiyuna T, Nelson SD, Dry SM, Li Y, Russell TA, Singh AS, Chmielowski B, Unno M, Eilber FC, Hoffman RM. Combination of gemcitabine and docetaxel regresses both gastric leiomyosarcoma proliferation and invasion in an imageable patient-derived orthotopic xenograft (iPDOX) model. Cell Cycle. 2017 Jun 03; 16(11):1063-1069. PMID: 28426279.
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    108. Hoffman RM. Is DNA methylation the new guardian of the genome? Mol Cytogenet. 2017; 10:11. PMID: 28396696.
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    109. Hoffman BL, Shensa A, Wessel C, Hoffman R, Primack BA. Exposure to fictional medical television and health: a systematic review. Health Educ Res. 2017 Apr 01; 32(2):107-123. PMID: 28334962.
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    110. Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Miwa S, Nelson SD, Dry SM, Li Y, Singh AS, Kimura H, Hayashi K, Yamamoto N, Tsuchiya H, Eilber FC, Hoffman RM. Temozolomide combined with irinotecan caused regression in an adult pleomorphic rhabdomyosarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model. Oncotarget. 2017 Sep 29; 8(44):75874-75880. PMID: 29100276.
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    111. Kawaguchi K, Murakami T, Suetsugu A, Kiyuna T, Igarashi K, Hiroshima Y, Zhao M, Zhang Y, Bouvet M, Clary BM, Unno M, Hoffman RM. High-efficacy targeting of colon-cancer liver metastasis with Salmonella typhimurium A1-R via intra-portal-vein injection in orthotopic nude-mouse models. Oncotarget. 2017 Mar 21; 8(12):19065-19073. PMID: 27683127.
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    112. Hoffman RM. The wayward methyl group and the cascade to cancer. Cell Cycle. 2017 May 03; 16(9):825-829. PMID: 28318368.
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    113. Murakami T, Kiyuna T, Kawaguchi K, Igarashi K, Singh AS, Hiroshima Y, Zhang Y, Zhao M, Miyake K, Nelson SD, Dry SM, Li Y, DeLong JC, Lwin TM, Chishima T, Tanaka K, Bouvet M, Endo I, Eilber FC, Hoffman RM. The irony of highly-effective bacterial therapy of a patient-derived orthotopic xenograft (PDOX) model of Ewing's sarcoma, which was blocked by Ewing himself 80 years ago. Cell Cycle. 2017 Jun 03; 16(11):1046-1052. PMID: 28296559.
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    114. Dai X, Liu D, Liu M, Zhang X, Wang W, Jin F, Qian Y, Wang X, Zhao J, Wu Y, Xiong F, Chang NA, Sun YU, Yang Z, Hoffman RM, Liu Y. Anti-metastatic Efficacy of Traditional Chinese Medicine (TCM) Ginsenoside Conjugated to a VEFGR-3 Antibody on Human Gastric Cancer in an Orthotopic Mouse Model. Anticancer Res. 2017 03; 37(3):979-986. PMID: 28314255.
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    115. Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Hoffman RM. Antimetastatic Efficacy of the Combination of Caffeine and Valproic Acid on an Orthotopic Human Osteosarcoma Cell Line Model in Nude Mice. Anticancer Res. 2017 03; 37(3):1005-1011. PMID: 28314258.
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    116. Hoffman RM, Singh AS, Eilber FC. Potential of immunotherapy for sarcoma. Cancer. 2017 May 01; 123(9):1488-1489. PMID: 28241102.
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    117. Yano S, Takehara K, Miwa S, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. GFP labeling kinetics of triple-negative human breast cancer by a killer-reporter adenovirus in 3D Gelfoam® histoculture. In Vitro Cell Dev Biol Anim. 2017 Jun; 53(6):479-482. PMID: 28233141.
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    118. Zhang S, Tang D, Zang W, Yin G, Dai J, Sun YU, Yang Z, Hoffman RM, Guo X. Synergistic Inhibitory Effect of Traditional Chinese Medicine Astragaloside IV and Curcumin on Tumor Growth and Angiogenesis in an Orthotopic Nude-Mouse Model of Human Hepatocellular Carcinoma. Anticancer Res. 2017 02; 37(2):465-473. PMID: 28179291.
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    119. Murakami T, Igarashi K, Kawaguchi K, Kiyuna T, Zhang Y, Zhao M, Hiroshima Y, Nelson SD, Dry SM, Li Y, Yanagawa J, Russell T, Federman N, Singh A, Elliott I, Matsuyama R, Chishima T, Tanaka K, Endo I, Eilber FC, Hoffman RM. Tumor-targeting Salmonella typhimurium A1-R regresses an osteosarcoma in a patient-derived xenograft model resistant to a molecular-targeting drug. Oncotarget. 2017 Jan 31; 8(5):8035-8042. PMID: 28030831.
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    120. Yano S, Takehara K, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. High-metastatic triple-negative breast-cancer variants selected in vivo become chemoresistant in vitro. In Vitro Cell Dev Biol Anim. 2017 Apr; 53(4):285-287. PMID: 28127701.
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    121. Hoover M, Adamian Y, Brown M, Maawy A, Chang A, Lee J, Gharibi A, Katz MH, Fleming J, Hoffman RM, Bouvet M, Doebler R, Kelber JA. A novel method for RNA extraction from FFPE samples reveals significant differences in biomarker expression between orthotopic and subcutaneous pancreatic cancer patient-derived xenografts. Oncotarget. 2017 Jan 24; 8(4):5885-5894. PMID: 27602776.
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    122. Murata T, Mekada E, Hoffman RM. Reconstitution of a metastatic-resistant tumor microenvironment with cancer-associated fibroblasts enables metastasis. Cell Cycle. 2017 Mar 19; 16(6):533-535. PMID: 28103135.
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    123. Hoffman BL, Hoffman R, Wessel CB, Shensa A, Woods MS, Primack BA. Use of fictional medical television in health sciences education: a systematic review. Adv Health Sci Educ Theory Pract. 2018 Mar; 23(1):201-216. PMID: 28083814.
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    124. Takehara K, Yano S, Tazawa H, Kishimoto H, Narii N, Mizuguchi H, Urata Y, Kagawa S, Fujiwara T, Hoffman RM. Eradication of melanoma in vitro and in vivo via targeting with a Killer-Red-containing telomerase-dependent adenovirus. Cell Cycle. 2017 Aug 18; 16(16):1502-1508. PMID: 28055296.
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    125. Yano S, Takehara K, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Fujiwara T, Bouvet M, Hoffman RM. Comparison of Tumor Recurrence After Resection of Highly- and Poorly-Metastatic Triple-negative Breast Cancer in Orthotopic Nude-Mouse Models. Anticancer Res. 2017 01; 37(1):57-60. PMID: 28011473.
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    126. Murakami T, Murata T, Kawaguchi K, Kiyuna T, Igarashi K, Hwang HK, Hiroshima Y, Hozumi C, Komatsu S, Kikuchi T, Lwin TM, Delong JC, Miyake K, Zhang Y, Tanaka K, Bouvet M, Endo I, Hoffman RM. Cervical Cancer Patient-Derived Orthotopic Xenograft (PDOX) Is Sensitive to Cisplatinum and Resistant to Nab-paclitaxel. Anticancer Res. 2017 01; 37(1):61-65. PMID: 28011474.
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    127. Kawaguchi K, Igarashi K, Murakami T, Chmielowski B, Kiyuna T, Zhao M, Zhang Y, Singh A, Unno M, Nelson SD, Russell TA, Dry SM, Li Y, Eilber FC, Hoffman RM. Tumor-targeting Salmonella typhimurium A1-R combined with temozolomide regresses malignant melanoma with a BRAF-V600E mutation in a patient-derived orthotopic xenograft (PDOX) model. Oncotarget. 2016 Dec 27; 7(52):85929-85936. PMID: 27835903.
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    128. Tome Y, Kimura H, Sugimoto N, Tsuchiya H, Kanaya F, Bouvet M, Hoffman RM. The disintegrin echistatin in combination with doxorubicin targets high-metastatic human osteosarcoma overexpressing a?ß3 integrin in chick embryo and nude mouse models. Oncotarget. 2016 Dec 27; 7(52):87031-87036. PMID: 27894082.
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    129. Yano S, Takehara K, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. Tumor-targeting adenovirus OBP-401 inhibits primary and metastatic tumor growth of triple-negative breast cancer in orthotopic nude-mouse models. Oncotarget. 2016 Dec 20; 7(51):85273-85282. PMID: 27863373.
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    130. Tanino H, Kosaka Y, Nishimiya H, Tanaka Y, Minatani N, Kikuchi M, Shida A, Waraya M, Katoh H, Enomoto T, Sengoku N, Kajita S, Hoffman RM, Watanabe M. BRCAness and Prognosis in Triple-Negative Breast Cancer Patients Treated with Neoadjuvant Chemotherapy. PLoS One. 2016; 11(12):e0165721. PMID: 27935989.
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    131. Yano S, Takehara K, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. In Vivo Selection of Intermediately- and Highly-Malignant Variants of Triple-negative Breast Cancer in Orthotopic Nude Mouse Models. Anticancer Res. 2016 12; 36(12):6273-6277. PMID: 27919946.
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    132. Tohgi N, Obara K, Yashiro M, Hamada Y, Arakawa N, Mii S, Aki R, Hoffman RM, Amoh Y. Human hair-follicle associated pluripotent (hHAP) stem cells differentiate to cardiac-muscle cells. Cell Cycle. 2017 Jan 02; 16(1):95-99. PMID: 27880068.
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    133. Shimozaki S, Yamamoto N, Domoto T, Nishida H, Hayashi K, Kimura H, Takeuchi A, Miwa S, Igarashi K, Kato T, Aoki Y, Higuchi T, Hirose M, Hoffman RM, Minamoto T, Tsuchiya H. Efficacy of glycogen synthase kinase-3ß targeting against osteosarcoma via activation of ß-catenin. Oncotarget. 2016 Nov 22; 7(47):77038-77051. PMID: 27780915.
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    134. Yano S, Takehara K, Miwa S, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. Fluorescence-guided surgery of a highly-metastatic variant of human triple-negative breast cancer targeted with a cancer-specific GFP adenovirus prevents recurrence. Oncotarget. 2016 11 15; 7(46):75635-75647. PMID: 27689331.
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    135. Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Miwa S, Nelson SD, Dry SM, Li Y, Singh A, Kimura H, Hayashi K, Yamamoto N, Tsuchiya H, Eilber FC, Hoffman RM. Patient-derived orthotopic xenograft (PDOX) mouse model of adult rhabdomyosarcoma invades and recurs after resection in contrast to the subcutaneous ectopic model. Cell Cycle. 2017 Jan 02; 16(1):91-94. PMID: 27830986.
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    136. Hiroshima Y, Maawy A, Zhang Y, Zhang N, Murakami T, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM. Patient-derived mouse models of cancer need to be orthotopic in order to evaluate targeted anti-metastatic therapy. Oncotarget. 2016 11 01; 7(44):71696-71702. PMID: 27765934.
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    137. Kawaguchi K, Murakami T, Chmielowski B, Igarashi K, Kiyuna T, Unno M, Nelson SD, Russell TA, Dry SM, Li Y, Eilber FC, Hoffman RM. Vemurafenib-resistant BRAF-V600E-mutated melanoma is regressed by MEK-targeting drug trametinib, but not cobimetinib in a patient-derived orthotopic xenograft (PDOX) mouse model. Oncotarget. 2016 Nov 01; 7(44):71737-71743. PMID: 27690220.
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    138. Yano S, Takehara K, Tazawa H, Kishimoto H, Kagawa S, Fujiwara T, Hoffman RM. Comparison of in vitro invasiveness of high- and low-metastatic triple-negative human breast cancer visualized by color-coded imaging. In Vitro Cell Dev Biol Anim. 2017 Feb; 53(2):96-98. PMID: 27778228.
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    139. Yano S, Takehara K, Tazawa H, Kishimoto H, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. Enhanced Metastatic Recurrence Via Lymphatic Trafficking of a High-Metastatic Variant of Human Triple-Negative Breast Cancer After Surgical Resection in Orthotopic Nude Mouse Models. J Cell Biochem. 2017 03; 118(3):559-569. PMID: 27626220.
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    140. Hiroshima Y, Lwin TM, Murakami T, Mawy AA, Kuniya T, Chishima T, Endo I, Clary BM, Hoffman RM, Bouvet M. Effective fluorescence-guided surgery of liver metastasis using a fluorescent anti-CEA antibody. J Surg Oncol. 2016 Dec; 114(8):951-958. PMID: 27696448.
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    141. Shirai K, Hamada Y, Arakawa N, Yamazaki A, Tohgi N, Aki R, Mii S, Hoffman RM, Amoh Y. Hypoxia Enhances Differentiation of Hair Follicle-Associated-Pluripotent (HAP) Stem Cells to Cardiac-Muscle Cells. J Cell Biochem. 2017 03; 118(3):554-558. PMID: 27627796.
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    142. Yano S, Takehara K, Tazawa H, Kishimoto H, Urata Y, Kagawa S, Fujiwara T, Hoffman RM. Efficacy of a Cell-Cycle Decoying Killer Adenovirus on 3-D Gelfoam®-Histoculture and Tumor-Sphere Models of Chemo-Resistant Stomach Carcinomatosis Visualized by FUCCI Imaging. PLoS One. 2016; 11(9):e0162991. PMID: 27673332.
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    143. Moreno JA, Sanchez A, Hoffman RM, Nur S, Lambros MP. Fluorescent Orthotopic Mouse Model of Pancreatic Cancer. J Vis Exp. 2016 09 20; (115). PMID: 27685334.
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    144. Zhang Y, Toneri M, Ma H, Yang Z, Bouvet M, Goto Y, Seki N, Hoffman RM. Real-Time GFP Intravital Imaging of the Differences in Cellular and Angiogenic Behavior of Subcutaneous and Orthotopic Nude-Mouse Models of Human PC-3 Prostate Cancer. J Cell Biochem. 2016 11; 117(11):2546-51. PMID: 27012365.
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    145. Igarashi K, Yamamoto N, Hayashi K, Takeuchi A, Kimura H, Miwa S, Hoffman RM, Tsuchiya H. Non-toxic Efficacy of the Combination of Caffeine and Valproic Acid on Human Osteosarcoma Cells In Vitro and in Orthotopic Nude-mouse Models. Anticancer Res. 2016 09; 36(9):4477-82. PMID: 27630284.
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    146. Matsumoto T, Suetsugu A, Hasegawa K, Nakamura M, Shibata Y, Aoki H, Kunisada T, Tsurumi H, Shimizu M, Bouvet M, Hoffman RM. A Mouse Model of Fluorescent Protein-expressing Disseminated Peritoneal Lymphoma for Fluorescence-guided Surgery. Anticancer Res. 2016 09; 36(9):4483-7. PMID: 27630285.
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    147. Hasegawa K, Suetsugu A, Nakamura M, Matsumoto T, Kunisada T, Shimizu M, Saji S, Moriwaki H, Bouvet M, Hoffman RM. Color-coded Imaging Enables Fluorescence-guided Surgery to Resect the Tumor Along with the Tumor Microenvironment in a Syngeneic Mouse Model of EL-4 Lymphoma. Anticancer Res. 2016 09; 36(9):4443-8. PMID: 27630280.
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    148. Yano S, Takehara K, Tazawa H, Kishimoto H, Urata Y, Kagawa S, Fujiwara T, Hoffman RM. Cell-cycle-dependent drug-resistant quiescent cancer cells induce tumor angiogenesis after chemotherapy as visualized by real-time FUCCI imaging. Cell Cycle. 2017 Mar 04; 16(5):406-414. PMID: 27715464.
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    149. Yamamoto M, Zhao M, Hiroshima Y, Zhang Y, Shurell E, Eilber FC, Bouvet M, Noda M, Hoffman RM. Efficacy of Tumor-Targeting Salmonella A1-R on a Melanoma Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Model. PLoS One. 2016; 11(8):e0160882. PMID: 27500926; PMCID: PMC4976963.
    150. Suetsugu A, Matsumoto T, Hasegawa K, Nakamura M, Kunisada T, Shimizu M, Saji S, Moriwaki H, Bouvet M, Hoffman RM. Color-coded Live Imaging of Heterokaryon Formation and Nuclear Fusion of Hybridizing Cancer Cells. Anticancer Res. 2016 Aug; 36(8):3827-31. PMID: 27466484.
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    151. Tome Y, Yano S, Sugimoto N, Mii S, Uehara F, Miwa S, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM. Use of av Integrin Linked to Green Fluorescent Protein in Osteosarcoma Cells and Confocal Microscopy to Image Molecular Dynamics During Lung Metastasis in Nude Mice. Anticancer Res. 2016 Aug; 36(8):3811-6. PMID: 27466481.
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    152. Tome Y, Uehara F, Miwa S, Yano S, Mii S, Efimova EV, Bouvet M, Kimura H, Tsuchiya H, Kanaya F, Hoffman RM. Efficacy of the Combination of a PARP Inhibitor and UVC on Cancer Cells as Imaged by Focus Formation by the DNA Repair-related Protein 53BP1 Linked to Green Fluorescent Protein. Anticancer Res. 2016 Aug; 36(8):3821-6. PMID: 27466483.
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    153. Yano S, Takehara K, Miwa S, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. In Vivo Isolation of a Highly-aggressive Variant of Triple-negative Human Breast Cancer MDA-MB-231 Using Serial Orthotopic Transplantation. Anticancer Res. 2016 Aug; 36(8):3817-20. PMID: 27466482.
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    154. Murakami T, Singh AS, Kiyuna T, Dry SM, Li Y, James AW, Igarashi K, Kawaguchi K, DeLong JC, Zhang Y, Hiroshima Y, Russell T, Eckardt MA, Yanagawa J, Federman N, Matsuyama R, Chishima T, Tanaka K, Bouvet M, Endo I, Eilber FC, Hoffman RM. Effective molecular targeting of CDK4/6 and IGF-1R in a rare FUS-ERG fusion CDKN2A-deletion doxorubicin-resistant Ewing's sarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model. Oncotarget. 2016 Jul 26; 7(30):47556-47564. PMID: 27286459.
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    155. Tome Y, Kimura H, Kiyuna T, Sugimoto N, Tsuchiya H, Kanaya F, Bouvet M, Hoffman RM. Disintegrin targeting of an avß3 integrin-over-expressing high-metastatic human osteosarcoma with echistatin inhibits cell proliferation, migration, invasion and adhesion in vitro. Oncotarget. 2016 07 19; 7(29):46315-46320. PMID: 27331872.
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    156. Yamazaki A, Hamada Y, Arakawa N, Yashiro M, Mii S, Aki R, Kawahara K, Hoffman RM, Amoh Y. Early-age-dependent selective decrease of differentiation potential of hair-follicle-associated pluripotent (HAP) stem cells to beating cardiac-muscle cells. Cell Cycle. 2016 Oct; 15(19):2619-2625. PMID: 27428074.
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    157. Kiyuna T, Murakami T, Tome Y, Igarashi K, Kawaguchi K, Russell T, Eckardt MA, Crompton J, Singh A, Bernthal N, Bukata S, Federman N, Kanaya F, Eilber FC, Hoffman RM. Labeling the Stroma of a Patient-Derived Orthotopic Xenograft (PDOX) Mouse Model of Undifferentiated Pleomorphic Soft-Tissue Sarcoma With Red Fluorescent Protein for Rapid Non-Invasive Imaging for Drug Screening. J Cell Biochem. 2017 02; 118(2):361-365. PMID: 27357060.
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    158. Tome Y, Yano S, Sugimoto N, Mii S, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM. Use of av Integrin Linked to GFP to Image Molecular Dynamics in Trafficking Cancer-Cell Emboli. J Cell Biochem. 2017 01; 118(1):26-30. PMID: 27191371.
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    159. Silva-Valenzuela CA, Desai PT, Molina-Quiroz RC, Pezoa D, Zhang Y, Porwollik S, Zhao M, Hoffman RM, Contreras I, Santiviago CA, McClelland M. Solid tumors provide niche-specific conditions that lead to preferential growth of Salmonella. Oncotarget. 2016 Jun 07; 7(23):35169-80. PMID: 27145267.
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    160. Yang H, Ding R, Tong Z, Huang J, Shen L, Sun YU, Liao J, Yang Z, Hoffman RM, Wang C, Meng X. siRNA Targeting of MDR1 Reverses Multidrug Resistance in a Nude Mouse Model of Doxorubicin-resistant Human Hepatocellular Carcinoma. Anticancer Res. 2016 Jun; 36(6):2675-82. PMID: 27272776.
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    161. Kiyuna T, Murakami T, Tome Y, Kawaguchi K, Igarashi K, Zhang Y, Zhao M, Li Y, Bouvet M, Kanaya F, Singh A, Dry S, Eilber FC, Hoffman RM. High efficacy of tumor-targeting Salmonella typhimurium A1-R on a doxorubicin- and dactolisib-resistant follicular dendritic-cell sarcoma in a patient-derived orthotopic xenograft PDOX nude mouse model. Oncotarget. 2016 May 31; 7(22):33046-54. PMID: 27105519.
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    162. Yano S, Takehara K, Zhao M, Tan Y, Han Q, Li S, Bouvet M, Fujiwara T, Hoffman RM. Tumor-specific cell-cycle decoy by Salmonella typhimurium A1-R combined with tumor-selective cell-cycle trap by methioninase overcome tumor intrinsic chemoresistance as visualized by FUCCI imaging. Cell Cycle. 2016 Jul 02; 15(13):1715-23. PMID: 27152859; PMCID: PMC4957602 [Available on 05/06/17].
    163. Murakami T, Zhang Y, Wang X, Hiroshima Y, Kasashima H, Yashiro M, Hirakawa K, Miwa A, Kiyuna T, Matsuyama R, Tanaka K, Bouvet M, Endo I, Hoffman RM. Orthotopic Implantation of Intact Tumor Tissue Leads to Metastasis of OCUM-2MD3 Human Gastric Cancer in Nude Mice Visualized in Real Time by Intravital Fluorescence Imaging. Anticancer Res. 2016 May; 36(5):2125-30. PMID: 27127113.
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    164. Xu X, Zhang L, Liu Z, Pan Y, Chen D, Yang Z, Deng Q, Cao X, Sun YU, Yang Z, Hoffman RM, Yuan H. Therapeutic Efficacy of the Traditional Chinese Medicine Baishaoqiwu on TNBS-induced Colitis is Associated with Down-regulation of the TLR4/MyD88/NF-?B Signaling Pathway. In Vivo. 2016 May-Jun; 30(3):181-6. PMID: 27107073.
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    165. Hasegawa K, Suetsugu A, Nakamura M, Matsumoto T, Aoki H, Kunisada T, Bouvet M, Shimizu M, Hoffman RM. Imaging Nuclear-Cytoplasmic Dynamics in Primary and Metastatic Colon Cancer in Nude Mice. Anticancer Res. 2016 May; 36(5):2113-7. PMID: 27127111.
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    166. Wang M, Zhang X, Xiong XI, Yang Z, Li P, Wang J, Sun YU, Yang Z, Hoffman RM. Bone Marrow Mesenchymal Stem Cells Reverse Liver Damage in a Carbon Tetrachloride-induced Mouse Model of Chronic Liver Injury. In Vivo. 2016 May-Jun; 30(3):187-93. PMID: 27107074.
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    167. Pajer K, Hoffman R, Gardner W, Chang CN, Boley D, Wang W. Endothelial dysfunction and negative emotions in adolescent girls. Int J Adolesc Med Health. 2016 May 01; 28(2):141-8. PMID: 25781670.
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    168. Liu B, Jiang Y, Dong T, Zhao M, Wu J, Li L, Chu Y, She S, Zhao H, Hoffman RM, Jia L. Blockage of autophagy pathway enhances Salmonella tumor-targeting. Oncotarget. 2016 Apr 19; 7(16):22873-82. PMID: 27013582; PMCID: PMC5008408.
    169. Miwa S, Toneri M, Igarashi K, Yano S, Kimura H, Hayashi K, Yamamoto N, Tsuchiya H, Hoffman RM. Real-Time In Vivo Confocal Fluorescence Imaging of Prostate Cancer Bone-Marrow Micrometastasis Development at the Cellular Level in Nude Mice. J Cell Biochem. 2016 11; 117(11):2533-7. PMID: 26990763.
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    170. Park JY, Lee JY, Zhang Y, Hoffman RM, Bouvet M. Targeting the insulin growth factor-1 receptor with fluorescent antibodies enables high resolution imaging of human pancreatic cancer in orthotopic mouse models. Oncotarget. 2016 Apr 05; 7(14):18262-8. PMID: 26919100; PMCID: PMC4951286.
    171. Yano S, Takehara K, Kishimoto H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. Adenoviral targeting of malignant melanoma for fluorescence-guided surgery prevents recurrence in orthotopic nude-mouse models. Oncotarget. 2016 Apr 05; 7(14):18558-72. PMID: 26701857; PMCID: PMC4951309.
    172. Hiroshima Y, Matsuo K, Kawaguchi D, Kikuchi Y, Endo I, Koda K, Togo S, Hoffman RM, Tanaka K. Modified Liver Hanging Maneuver for En-bloc Right-sided Hepatectomy Combined with Total Caudate Lobectomy for Colon-Cancer Liver Metastasis and Hepatocellular Carcinoma. Anticancer Res. 2016 Apr; 36(4):1729-35. PMID: 27069152.
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    173. Matsumoto T, Suetsugu A, Hasegawa K, Nakamura M, Aoki H, Kunisada T, Tsurumi H, Shimizu M, Hoffman RM. Color-Coded Imaging of Syngeneic Orthotopic Malignant Lymphoma Interacting with Host Stromal Cells During Metastasis. Anticancer Res. 2016 Apr; 36(4):1473-8. PMID: 27069122.
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    174. Chen P, Hu T, Liang Y, Li P, Chen X, Zhang J, Ma Y, Hao Q, Wang J, Zhang P, Zhang Y, Zhao H, Yang S, Yu J, Jeong LS, Qi H, Yang M, Hoffman RM, Dong Z, Jia L. Neddylation Inhibition Activates the Extrinsic Apoptosis Pathway through ATF4-CHOP-DR5 Axis in Human Esophageal Cancer Cells. Clin Cancer Res. 2016 Aug 15; 22(16):4145-57. PMID: 26983464.
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    175. Murakami T, DeLong J, Eilber FC, Zhao M, Zhang Y, Zhang N, Singh A, Russell T, Deng S, Reynoso J, Quan C, Hiroshima Y, Matsuyama R, Chishima T, Tanaka K, Bouvet M, Chawla S, Endo I, Hoffman RM. Tumor-targeting Salmonella typhimurium A1-R in combination with doxorubicin eradicate soft tissue sarcoma in a patient-derived orthotopic xenograft (PDOX) model. Oncotarget. 2016 Mar 15; 7(11):12783-90. PMID: 26859573; PMCID: PMC4914321.
    176. Hoffman RM. Use of fluorescent proteins and color-coded imaging to visualize cancer cells with different genetic properties. Cancer Metastasis Rev. 2016 Mar; 35(1):5-19. PMID: 26942457.
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    177. Sun J, Ling B, Xu X, Ma R, Li G, Cao X, Ling W, Yang Z, Hoffman RM, Lu J. Decreased Expression of Tumor-suppressor Gene LKB1 Correlates with Poor Prognosis in Human Gastric Cancer. Anticancer Res. 2016 Mar; 36(3):869-75. PMID: 26976973.
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    178. Binder DC, Arina A, Wen F, Tu T, Zhao M, Hoffman RM, Wainwright DA, Schreiber H. Tumor relapse prevented by combining adoptive T cell therapy with Salmonella typhimurium. Oncoimmunology. 2016 Jun; 5(6):e1130207. PMID: 27471609; PMCID: PMC4938310 [Available on 02/18/17].
    179. Yano S, Takehara K, Miwa S, Kishimoto H, Hiroshima Y, Murakami T, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. Improved Resection and Outcome of Colon-Cancer Liver Metastasis with Fluorescence-Guided Surgery Using In Situ GFP Labeling with a Telomerase-Dependent Adenovirus in an Orthotopic Mouse Model. PLoS One. 2016; 11(2):e0148760. PMID: 26849435; PMCID: PMC4743860.
    180. Jun E, Jung J, Jeong SY, Choi EK, Kim MB, Lee JS, Hong SM, Seol HS, Hwang C, Hoffman RM, Shim IK, Chang S, Kim SC. Surgical and Oncological Factors Affecting the Successful Engraftment of Patient-derived Xenografts in Pancreatic Ductal Adenocarcinoma. Anticancer Res. 2016 Feb; 36(2):517-21. PMID: 26851005.
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    181. Miwa S, De Magalhães N, Toneri M, Zhang Y, Cao W, Bouvet M, Tsuchiya H, Hoffman RM. Fluorescence-guided surgery of human prostate cancer experimental bone metastasis in nude mice using anti-CEA DyLight 650 for tumor illumination. J Orthop Res. 2016 Apr; 34(4):559-65. PMID: 26135883.
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    182. Silva-Valenzuela CA, Molina-Quiroz RC, Desai P, Valenzuela C, Porwollik S, Zhao M, Hoffman RM, Andrews-Polymenis H, Contreras I, Santiviago CA, McClelland M. Analysis of Two Complementary Single-Gene Deletion Mutant Libraries of Salmonella Typhimurium in Intraperitoneal Infection of BALB/c Mice. Front Microbiol. 2015; 6:1455. PMID: 26779130; PMCID: PMC4700939.
    183. Park JY, Murakami T, Lee JY, Zhang Y, Hoffman RM, Bouvet M. Fluorescent-Antibody Targeting of Insulin-Like Growth Factor-1 Receptor Visualizes Metastatic Human Colon Cancer in Orthotopic Mouse Models. PLoS One. 2016; 11(1):e0146504. PMID: 26731105; PMCID: PMC4701661.
    184. Cao W, Li L, Kajiura S, Amoh Y, Tan Y, Liu F, Hoffman RM. Aging hair follicles rejuvenated by transplantation to a young subcutaneous environment. Cell Cycle. 2016; 15(8):1093-8. PMID: 26940664; PMCID: PMC4889257 [Available on 03/03/17].
    185. Hoffman RM, Zhao M. Methods for Tumor Targeting with Salmonella typhimurium A1-R. Methods Mol Biol. 2016; 1409:143-64. PMID: 26846809.
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    186. Yamazaki A, Yashiro M, Mii S, Aki R, Hamada Y, Arakawa N, Kawahara K, Hoffman RM, Amoh Y. Isoproterenol directs hair follicle-associated pluripotent (HAP) stem cells to differentiate in vitro to cardiac muscle cells which can be induced to form beating heart-muscle tissue sheets. Cell Cycle. 2016; 15(5):760-5. PMID: 27104748; PMCID: PMC4845933 [Available on 03/30/17].
    187. Hoffman RM, Yano S. Salmonella typhimurium A1-R and Cell-Cycle Decoy Therapy of Cancer. Methods Mol Biol. 2016; 1409:165-75. PMID: 26846810.
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    188. Hoffman RM. Tumor-Targeting Salmonella typhimurium A1-R: An Overview. Methods Mol Biol. 2016; 1409:1-8. PMID: 26846797.
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    189. Hoffman RM. Future of Bacterial Therapy of Cancer. Methods Mol Biol. 2016; 1409:177-84. PMID: 26846811.
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    190. Li L, Hoffman RM. Discovery of HAP Stem Cells. Methods Mol Biol. 2016; 1453:15-20. PMID: 27431242.
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    191. Cao W, Liu F, Amoh Y, Hoffman RM. Protocols for Ectopic Hair Growth from Transplanted Whisker Follicles on the Spinal Cord of Mice. Methods Mol Biol. 2016; 1453:137-44. PMID: 27431253.
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    192. Hoffman RM. Introduction to Hair-Follicle-Associated Pluripotent Stem Cells. Methods Mol Biol. 2016; 1453:1-5. PMID: 27431240.
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    193. Yashiro M, Mii S, Aki R, Hamada Y, Arakawa N, Kawahara K, Hoffman RM, Amoh Y. Protocols for Efficient Differentiation of Hair Follicle-Associated Pluripotent (HAP) Stem Cells to Beating Cardiac Muscle Cells. Methods Mol Biol. 2016; 1453:151-9. PMID: 27431255.
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    194. Kajiura S, Mii S, Aki R, Hamada Y, Arakawa N, Kawahara K, Li L, Katsuoka K, Hoffman RM, Amoh Y. Protocols for Cryopreservation of Intact Hair Follicle That Maintain Pluripotency of Nestin-Expressing Hair-Follicle-Associated Pluripotent (HAP) Stem Cells. Methods Mol Biol. 2016; 1453:173-8. PMID: 27431257.
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    195. Amoh Y, Katsuoka K, Hoffman RM. Peripheral-Nerve and Spinal-Cord Regeneration in Mice Using Hair-Follicle-Associated Pluripotent (HAP) Stem Cells. Methods Mol Biol. 2016; 1453:21-32. PMID: 27431243.
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    196. Mii S, Duong J, Tome Y, Uchugonova A, Liu F, Amoh Y, Saito N, Katsuoka K, Hoffman RM. Nestin-Expressing Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Promote Whisker Sensory-Nerve Growth in Long-Term 3D-Gelfoam® Histoculture. Methods Mol Biol. 2016; 1453:39-47. PMID: 27431245.
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    197. Cao W, Liu F, Amoh Y, Hoffman RM. Protocols for Gelfoam(®) Histoculture of Hair-Shaft-Producing Mouse Whisker Follicles Containing Nestin-GFP-Expressing Hair-Follicle-Associated Pluripotent (HAP) Stem Cells for Long Time Periods. Methods Mol Biol. 2016; 1453:145-50. PMID: 27431254.
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    198. Hoffman RM, Kajiura S, Cao W, Liu F, Amoh Y. Cryopreservation of Hair-Follicle Associated Pluripotent (HAP) Stem Cells Maintains Differentiation and Hair-Growth Potential. Adv Exp Med Biol. 2016; 951:191-198. PMID: 27837565.
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    199. Cao W, Li L, Tran B, Kajiura S, Amoh Y, Liu F, Hoffman RM. Extensive Hair Shaft Growth after Mouse Whisker Follicle Isolation, Cryopreservation and Transplantation in Nude Mice. PLoS One. 2015; 10(12):e0145997. PMID: 26716690; PMCID: PMC4696652.
    200. Hoffman RM, Bouvet M. Imaging the microenvironment of pancreatic cancer patient-derived orthotopic xenografts (PDOX) growing in transgenic nude mice expressing GFP, RFP, or CFP. Cancer Lett. 2016 09 28; 380(1):349-55. PMID: 26742463.
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    201. Murakami T, Hiroshima Y, Zhao M, Zhang Y, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM. Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model. Oncotarget. 2015 Dec 08; 6(39):41856-62. PMID: 26497690; PMCID: PMC4747193.
    202. DeLong JC, Hoffman RM, Bouvet M. Current status and future perspectives of fluorescence-guided surgery for cancer. Expert Rev Anticancer Ther. 2016; 16(1):71-81. PMID: 26567611.
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    203. Suetsugu A, Momiyama M, Hiroshima Y, Shimizu M, Saji S, Moriwaki H, Bouvet M, Hoffman RM. Color-Coded Imaging of Breast Cancer Metastatic Niche Formation in Nude Mice. J Cell Biochem. 2015 Dec; 116(12):2730-4. PMID: 25981355; PMCID: PMC4600030 [Available on 12/01/16].
    204. Zhang L, Wu C, Hoffman RM. Prostate Cancer Heterogeneous High-Metastatic Multi-Organ-Colonizing Chemo-Resistant Variants Selected by Serial Metastatic Passage in Nude Mice Are Highly Enriched for Multinucleate Giant Cells. PLoS One. 2015; 10(11):e0140721. PMID: 26536025; PMCID: PMC4633180.
    205. Yano S, Miwa S, Kishimoto H, Urata Y, Tazawa H, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. Eradication of osteosarcoma by fluorescence-guided surgery with tumor labeling by a killer-reporter adenovirus. J Orthop Res. 2016 05; 34(5):836-44. PMID: 26479501.
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    206. Suetsugu A, Hiroshima Y, Matsumoto T, Hasagawa K, Nakamura M, Shimizu M, Saji S, Moriwaki H, Bouvet M, Hoffman RM. Recruitment of Cancer-Associated Fibroblasts and Blood Vessels by Orthotopic Liver Tumors Imaged in Red Fluorescent Protein (RFP) Transgenic Nude Mice. Anticancer Res. 2015 Nov; 35(11):5821-5. PMID: 26504003.
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    207. Zhang Y, Wang X, Hoffman RM, Seki N. Real Time Metastatic Route Tracking of Orthotopic PC-3-GFP Human Prostate Cancer Using Intravital Imaging. J Cell Biochem. 2016 Apr; 117(4):1027-32. PMID: 26515240.
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    208. Toneri M, Miwa S, Zhang Y, Hu C, Yano S, Matsumoto Y, Bouvet M, Nakanishi H, Hoffman RM, Zhao M. Tumor-targeting Salmonella typhimurium A1-R inhibits human prostate cancer experimental bone metastasis in mouse models. Oncotarget. 2015 Oct 13; 6(31):31335-43. PMID: 26431498; PMCID: PMC4741609.
    209. Murakami T, Hiroshima Y, Zhao M, Zhang Y, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM. Therapeutic efficacy of tumor-targeting Salmonella typhimurium A1-R on human colorectal cancer liver metastasis in orthotopic nude-mouse models. Oncotarget. 2015 Oct 13; 6(31):31368-77. PMID: 26375054; PMCID: PMC4741612.
    210. Uchugonova A, Zhang Y, Salz R, Liu F, Suetsugu A, Zhang L, Koenig K, Hoffman RM, Zhao M. Imaging the Different Mechanisms of Prostate Cancer Cell-killing by Tumor-targeting Salmonella typhimurium A1-R. Anticancer Res. 2015 Oct; 35(10):5225-9. PMID: 26408681.
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    211. Murakami T, Hiroshima Y, Zhang Y, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM. Fluorescence-Guided Surgery of Liver Metastasis in Orthotopic Nude-Mouse Models. PLoS One. 2015; 10(10):e0138752. PMID: 26427050; PMCID: PMC4591295.
    212. Cao W, Li L, Mii S, Amoh Y, Liu F, Hoffman RM. Extensive Hair-Shaft Elongation by Isolated Mouse Whisker Follicles in Very Long-Term Gelfoam® Histoculture. PLoS One. 2015; 10(9):e0138005. PMID: 26421923; PMCID: PMC4589329.
    213. Yano S, Zhang Y, Miwa S, Kishimoto H, Urata Y, Bouvet M, Kagawa S, Fujiwara T, Hoffman RM. Precise navigation surgery of tumours in the lung in mouse models enabled by in situ fluorescence labelling with a killer-reporter adenovirus. BMJ Open Respir Res. 2015; 2(1):e000096. PMID: 26380093; PMCID: PMC4567685.
    214. Matsumoto T, Suetsugu A, Shibata Y, Nakamura N, Aoki H, Kunisada T, Tsurumi H, Shimizu M, Hoffman RM. A Color-coded Imageable Syngeneic Mouse Model of Stromal-cell Recruitment by Metastatic Lymphoma. Anticancer Res. 2015 Sep; 35(9):4647-54. PMID: 26254354.
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    215. Hu T, Qi H, Li P, Zhao G, Ma Y, Hao Q, Gao C, Zhang Y, Wang C, Yang M, Hoffman RM, Chen P, Dong Z. Comparison of GFP-Expressing Imageable Mouse Models of Human Esophageal Squamous Cell Carcinoma Established in Various Anatomical Sites. Anticancer Res. 2015 Sep; 35(9):4655-63. PMID: 26254355.
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    216. Zhang Y, Zhang N, Hoffman RM, Zhao M. Surgically-Induced Multi-organ Metastasis in an Orthotopic Syngeneic Imageable Model of 4T1 Murine Breast Cancer. Anticancer Res. 2015 Sep; 35(9):4641-6. PMID: 26254353.
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    217. Murakami T, Hiroshima Y, Zhang Y, Bouvet M, Chishima T, Tanaka K, Endo I, Hoffman RM. Improved disease-free survival and overall survival after fluorescence-guided surgery of liver metastasis in an orthotopic nude mouse model. J Surg Oncol. 2015 Aug; 112(2):119-24. PMID: 26266663.
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    218. Cao W, Li L, Mii S, Amoh Y, Liu F, Hoffman RM. Long-Term Extensive Ectopic Hair Growth on the Spinal Cord of Mice from Transplanted Whisker Follicles. PLoS One. 2015; 10(8):e0133475. PMID: 26244638; PMCID: PMC4526646.
    219. Hiroshima Y, Zhao M, Zhang Y, Zhang N, Maawy A, Murakami T, Mii S, Uehara F, Yamamoto M, Miwa S, Yano S, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM. Tumor-Targeting Salmonella typhimurium A1-R Arrests a Chemo-Resistant Patient Soft-Tissue Sarcoma in Nude Mice. PLoS One. 2015; 10(8):e0134324. PMID: 26237416; PMCID: PMC4523197.
    220. Hoffman RM. Patient-derived orthotopic xenografts: better mimic of metastasis than subcutaneous xenografts. Nat Rev Cancer. 2015 08; 15(8):451-2. PMID: 26422835.
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    221. Zhang Y, Zhang N, Zhao M, Hoffman RM. Real-time Non-invasive Spectral Imaging of Orthotopic Red Fluorescent Protein-expressing Lung Tumor Growth in Nude Mice. Anticancer Res. 2015 Jul; 35(7):3755-9. PMID: 26124318.
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    222. Zhang Y, Zhang N, Zhao M, Hoffman RM. Comparison of the selective targeting efficacy of Salmonella typhimurium A1-R and VNP20009 on the Lewis lung carcinoma in nude mice. Oncotarget. 2015 Jun 10; 6(16):14625-31. PMID: 25714030; PMCID: PMC4546492.
    223. Hiroshima Y, Zhang Y, Zhao M, Zhang N, Murakami T, Maawy A, Mii S, Uehara F, Yamamoto M, Miwa S, Yano S, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM. Tumor-Targeting Salmonella typhimurium A1-R in Combination with Trastuzumab Eradicates HER-2-Positive Cervical Cancer Cells in Patient-Derived Mouse Models. PLoS One. 2015; 10(6):e0120358. PMID: 26047477; PMCID: PMC4457918.
    224. Yin G, Tang D, Dai J, Liu M, Wu M, Sun YU, Yang Z, Hoffman RM, Li L, Zhang S, Guo X. Combination Efficacy of Astragalus membranaceus and Curcuma wenyujin at Different Stages of Tumor Progression in an Imageable Orthotopic Nude Mouse Model of Metastatic Human Ovarian Cancer Expressing Red Fluorescent Protein. Anticancer Res. 2015 Jun; 35(6):3193-207. PMID: 26026079.
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    225. Yano S, Miwa S, Kishimoto H, Uehara F, Tazawa H, Toneri M, Hiroshima Y, Yamamoto M, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. Targeting tumors with a killer-reporter adenovirus for curative fluorescence-guided surgery of soft-tissue sarcoma. Oncotarget. 2015 May 30; 6(15):13133-48. PMID: 26033451; PMCID: PMC4537004.
    226. Li H, He J, Zhong N, Hoffman RM. Drug exposure in a metastatic human lung adenocarcinoma cell line gives rise to cells with differing adhesion, proliferation, and gene expression: Implications for cancer chemotherapy. Mol Med Rep. 2015 Sep; 12(3):3236-42. PMID: 26004767; PMCID: PMC4526089.
    227. Yashiro M, Mii S, Aki R, Hamada Y, Arakawa N, Kawahara K, Hoffman RM, Amoh Y. From hair to heart: nestin-expressing hair-follicle-associated pluripotent (HAP) stem cells differentiate to beating cardiac muscle cells. Cell Cycle. 2015; 14(14):2362-6. PMID: 25970547; PMCID: PMC4614865.
    228. Matsumoto Y, Miwa S, Zhang Y, Zhao M, Yano S, Uehara F, Yamamoto M, Hiroshima Y, Toneri M, Bouvet M, Matsubara H, Tsuchiya H, Hoffman RM. Intraperitoneal administration of tumor-targeting Salmonella typhimurium A1-R inhibits disseminated human ovarian cancer and extends survival in nude mice. Oncotarget. 2015 May 10; 6(13):11369-77. PMID: 25957417; PMCID: PMC4484462.
    229. Yang M, Jiang P, Hoffman RM. Early Reporting of Apoptosis by Real-time Imaging of Cancer Cells Labeled with Green Fluorescent Protein in the Nucleus and Red Fluorescent Protein in the Cytoplasm. Anticancer Res. 2015 May; 35(5):2539-43. PMID: 25964527.
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    230. Suetsugu A, Snyder CS, Moriwaki H, Saji S, Bouvet M, Hoffman RM. Imaging the Interaction of Pancreatic Cancer and Stellate Cells in the Tumor Microenvironment during Metastasis. Anticancer Res. 2015 May; 35(5):2545-51. PMID: 25964528.
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    231. Suetsugu A, Jiang P, Yang M, Yamamoto N, Moriwaki H, Saji S, Hoffman RM. The Use of Living Cancer Cells Expressing Green Fluorescent Protein in the Nucleus and Red Fluorescence Protein in the Cytoplasm for Real-time Confocal Imaging of Chromosome and Cytoplasmic Dynamics During Mitosis. Anticancer Res. 2015 May; 35(5):2553-7. PMID: 25964529.
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    232. Hoffman RM, Bouvet M. Nanoparticle albumin-bound-paclitaxel: a limited improvement under the current therapeutic paradigm of pancreatic cancer. Expert Opin Pharmacother. 2015 May; 16(7):943-7. PMID: 25887245.
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    233. Bouvet M, Hoffman RM. Toward Curative Fluorescence-Guided Surgery of Pancreatic Cancer. Hepatogastroenterology. 2015 May; 62(139):715-22. PMID: 26897960.
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    234. Yano S, Miwa S, Kishimoto H, Toneri M, Hiroshima Y, Yamamoto M, Bouvet M, Urata Y, Tazawa H, Kagawa S, Fujiwara T, Hoffman RM. Experimental Curative Fluorescence-guided Surgery of Highly Invasive Glioblastoma Multiforme Selectively Labeled With a Killer-reporter Adenovirus. Mol Ther. 2015 Jul; 23(7):1182-1188. PMID: 25896244; PMCID: PMC4817790.
    235. Chen P, Hu T, Liang Y, Jiang Y, Pan Y, Li C, Zhang P, Wei D, Li P, Jeong LS, Chu Y, Qi H, Yang M, Hoffman RM, Dong Z, Jia L. Synergistic inhibition of autophagy and neddylation pathways as a novel therapeutic approach for targeting liver cancer. Oncotarget. 2015 Apr 20; 6(11):9002-17. PMID: 25797246; PMCID: PMC4496198.
    236. Hiroshima Y, Maawy A, Zhang Y, Guzman MG, Heim R, Makings L, Luiken GA, Kobayashi H, Tanaka K, Endo I, Hoffman RM, Bouvet M. Photoimmunotherapy Inhibits Tumor Recurrence After Surgical Resection on a Pancreatic Cancer Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model. Ann Surg Oncol. 2015 Dec; 22 Suppl 3:S1469-74. PMID: 25893411.
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    237. Kajiura S, Mii S, Aki R, Hamada Y, Arakawa N, Kawahara K, Li L, Katsuoka K, Hoffman RM, Amoh Y. Cryopreservation of the Hair Follicle Maintains Pluripotency of Nestin-Expressing Hair Follicle-Associated Pluripotent Stem Cells. Tissue Eng Part C Methods. 2015 Aug; 21(8):825-31. PMID: 25743086; PMCID: PMC4523096.
    238. Miwa S, Yano S, Yamamoto M, Matsumoto Y, Uehara F, Hiroshima Y, Toneri M, Murakami T, Kimura H, Hayashi K, Yamamoto N, Efimova EV, Tsuchiya H, Hoffman RM. Real-time fluorescence imaging of the DNA damage repair response during mitosis. J Cell Biochem. 2015 Apr; 116(4):661-6. PMID: 25418288.
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    239. Park JY, Hiroshima Y, Lee JY, Maawy AA, Hoffman RM, Bouvet M. MUC1 selectively targets human pancreatic cancer in orthotopic nude mouse models. PLoS One. 2015; 10(3):e0122100. PMID: 25815753; PMCID: PMC4376872.
    240. Maawy AA, Hiroshima Y, Zhang Y, Heim R, Makings L, Garcia-Guzman M, Luiken GA, Kobayashi H, Hoffman RM, Bouvet M. Near infra-red photoimmunotherapy with anti-CEA-IR700 results in extensive tumor lysis and a significant decrease in tumor burden in orthotopic mouse models of pancreatic cancer. PLoS One. 2015; 10(3):e0121989. PMID: 25799218; PMCID: PMC4370703.
    241. Zhang L, Wu C, Bouvet M, Yano S, Hoffman RM. Traditional Chinese medicine herbal mixture LQ arrests FUCCI-expressing HeLa cells in G0/G1 phase in 2D plastic, 2.5D Matrigel, and 3D Gelfoam culture visualized with FUCCI imaging. Oncotarget. 2015 Mar 10; 6(7):5292-8. PMID: 25779660; PMCID: PMC4467149.
    242. Hiroshima Y, Maawy A, Zhang Y, Murakami T, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Endo I, Hoffman RM, Bouvet M. Fluorescence-guided surgery, but not bright-light surgery, prevents local recurrence in a pancreatic cancer patient derived orthotopic xenograft (PDOX) model resistant to neoadjuvant chemotherapy (NAC). Pancreatology. 2015 May-Jun; 15(3):295-301. PMID: 25800176; PMCID: PMC4446223.
    243. Hoffman RM. Nestin-expressing hair follicle-accessible pluripotent stem cells for nerve and spinal cord repair. Cells Tissues Organs. 2014; 200(1):42-7. PMID: 25766743.
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    244. Bouvet M, Hoffman RM. Fluorescence-guided surgery: it is the cure that matters: in reply to Giorgakis and colleagues. J Am Coll Surg. 2015 Mar; 220(3):377-9. PMID: 25700908.
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    245. Uehara F, Hiroshima Y, Miwa S, Tome Y, Yano S, Yamamoto M, Matsumoto Y, Maehara H, Tanaka K, Bouvet M, Kanaya F, Hoffman RM. Fluorescence-guided surgery of retroperitoneal-implanted human fibrosarcoma in nude mice delays or eliminates tumor recurrence and increases survival compared to bright-light surgery. PLoS One. 2015; 10(2):e0116865. PMID: 25710463; PMCID: PMC4339719.
    246. Zhang Y, Miwa S, Zhang N, Hoffman RM, Zhao M. Tumor-targeting Salmonella typhimurium A1-R arrests growth of breast-cancer brain metastasis. Oncotarget. 2015 Feb 20; 6(5):2615-22. PMID: 25575815; PMCID: PMC4413605.
    247. Maawy AA, Hiroshima Y, Zhang Y, Garcia-Guzman M, Luiken GA, Kobayashi H, Hoffman RM, Bouvet M. Photoimmunotherapy lowers recurrence after pancreatic cancer surgery in orthotopic nude mouse models. J Surg Res. 2015 Jul; 197(1):5-11. PMID: 25799527; PMCID: PMC4457622.
    248. Hiroshima Y, Zhang Y, Zhang N, Maawy A, Mii S, Yamamoto M, Uehara F, Miwa S, Yano S, Murakami T, Momiyama M, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Murata T, Endo I, Hoffman RM. Establishment of a patient-derived orthotopic Xenograft (PDOX) model of HER-2-positive cervical cancer expressing the clinical metastatic pattern. PLoS One. 2015; 10(2):e0117417. PMID: 25689852.
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    249. Hoffman RM. Application of GFP imaging in cancer. Lab Invest. 2015 Apr; 95(4):432-52. PMID: 25686095; PMCID: PMC4383682.
    250. Zhang Y, Hiroshima Y, Ma H, Zhang N, Zhao M, Hoffman RM. Complementarity of variable-magnification and spectral-separation fluorescence imaging systems for noninvasive detection of metastasis and intravital detection of single cancer cells in mouse models. Anticancer Res. 2015 Feb; 35(2):661-7. PMID: 25667443.
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    251. Hiroshima Y, Zhang Y, Zhang N, Uehara F, Maawy A, Murakami T, Mii S, Yamamoto M, Miwa S, Yano S, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM. Patient-derived orthotopic xenograft (PDOX) nude mouse model of soft-tissue sarcoma more closely mimics the patient behavior in contrast to the subcutaneous ectopic model. Anticancer Res. 2015 Feb; 35(2):697-701. PMID: 25667448.
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    252. Bouvet M, Hoffman RM. Tumor imaging technologies in mouse models. Methods Mol Biol. 2015; 1267:321-48. PMID: 25636477.
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    253. Hoffman RM. Back to the Future: Are Tumor-Targeting Bacteria the Next-Generation Cancer Therapy? Methods Mol Biol. 2015; 1317:239-60. PMID: 26072411.
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    254. Yano S, Miwa S, Mii S, Hiroshima Y, Uehara F, Kishimoto H, Tazawa H, Zhao M, Bouvet M, Fujiwara T, Hoffman RM. Cancer cells mimic in vivo spatial-temporal cell-cycle phase distribution and chemosensitivity in 3-dimensional Gelfoam® histoculture but not 2-dimensional culture as visualized with real-time FUCCI imaging. Cell Cycle. 2015; 14(6):808-19. PMID: 25564963; PMCID: PMC4614530.
    255. Miwa S, Yano S, Kimura H, Yamamoto M, Toneri M, Matsumoto Y, Uehara F, Hiroshima Y, Murakami T, Hayashi K, Yamamoto N, Bouvet M, Fujiwara T, Tsuchiya H, Hoffman RM. Cell-cycle fate-monitoring distinguishes individual chemosensitive and chemoresistant cancer cells in drug-treated heterogeneous populations demonstrated by real-time FUCCI imaging. Cell Cycle. 2015; 14(4):621-9. PMID: 25551170; PMCID: PMC4613186.
    256. Uchugonova A, Cao W, Hoffman RM, Koenig K. Comparison of label-free and GFP multiphoton imaging of hair follicle-associated pluripotent (HAP) stem cells in mouse whiskers. Cell Cycle. 2015; 14(21):3430-3. PMID: 26397024; PMCID: PMC4825630.
    257. Miwa S, Yano S, Kimura H, Yamamoto M, Toneri M, Murakami T, Hayashi K, Yamamoto N, Fujiwara T, Tsuchiya H, Hoffman RM. Heterogeneous cell-cycle behavior in response to UVB irradiation by a population of single cancer cells visualized by time-lapse FUCCI imaging. Cell Cycle. 2015; 14(12):1932-7. PMID: 25946083; PMCID: PMC4615034.
    258. Miwa S, Zhang Y, Baek KE, Uehara F, Yano S, Yamamoto M, Hiroshima Y, Matsumoto Y, Kimura H, Hayashi K, Yamamoto N, Bouvet M, Tsuchiya H, Hoffman RM, Zhao M. Inhibition of spontaneous and experimental lung metastasis of soft-tissue sarcoma by tumor-targeting Salmonella typhimurium A1-R. Oncotarget. 2014 Dec 30; 5(24):12849-61. PMID: 25528763; PMCID: PMC4350333.
    259. Kikuchi S, Kishimoto H, Tazawa H, Hashimoto Y, Kuroda S, Nishizaki M, Nagasaka T, Shirakawa Y, Kagawa S, Urata Y, Hoffman RM, Fujiwara T. Biological ablation of sentinel lymph node metastasis in submucosally invaded early gastrointestinal cancer. Mol Ther. 2015 Mar; 23(3):501-9. PMID: 25523761; PMCID: PMC4351467.
    260. Hiroshima Y, Zhang Y, Murakami T, Maawy A, Miwa S, Yamamoto M, Yano S, Sato S, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Zhao M, Hoffman RM. Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models. Oncotarget. 2014 Dec 15; 5(23):12346-57. PMID: 25402324; PMCID: PMC4322966.
    261. Hoffman RM. Development of recombinant methioninase to target the general cancer-specific metabolic defect of methionine dependence: a 40-year odyssey. Expert Opin Biol Ther. 2015 Jan; 15(1):21-31. PMID: 25439528.
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    262. Hiroshima Y, Maawy A, Zhang Y, Murakami T, Momiyama M, Mori R, Matsuyama R, Katz MH, Fleming JB, Chishima T, Tanaka K, Ichikawa Y, Endo I, Hoffman RM, Bouvet M. Metastatic recurrence in a pancreatic cancer patient derived orthotopic xenograft (PDOX) nude mouse model is inhibited by neoadjuvant chemotherapy in combination with fluorescence-guided surgery with an anti-CA 19-9-conjugated fluorophore. PLoS One. 2014; 9(12):e114310. PMID: 25463150; PMCID: PMC4252107.
    263. Kim KY, Chung BW, Yang I, Kim MB, Hoffman RM. Independence of cytotoxic drug sensitivity profiles and receptor subtype of invasive ductal breast carcinoma demonstrated by the histoculture drug response assay (HDRA). Anticancer Res. 2014 Dec; 34(12):7197-201. PMID: 25503149.
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    264. Hoffman RM. Orthotopic mouse models of tumor metastasis expressing fluorescent reporters produce imageable circulating tumor cells. Cancer Microenviron. 2014 Dec; 7(3):133-8. PMID: 25417145; PMCID: PMC4275499.
    265. Hiroshima Y, Maawy AA, Katz MH, Fleming JB, Bouvet M, Endo I, Hoffman RM. Selective efficacy of zoledronic acid on metastasis in a patient-derived orthotopic xenograph (PDOX) nude-mouse model of human pancreatic cancer. J Surg Oncol. 2015 Mar; 111(3):311-5. PMID: 25394368.
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    266. Matsumoto Y, Miwa S, Zhang Y, Hiroshima Y, Yano S, Uehara F, Yamamoto M, Toneri M, Bouvet M, Matsubara H, Hoffman RM, Zhao M. Efficacy of tumor-targeting Salmonella typhimurium A1-R on nude mouse models of metastatic and disseminated human ovarian cancer. J Cell Biochem. 2014 Nov; 115(11):1996-2003. PMID: 24924355.
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    267. Hoffman RM. Circulating tumour cells go green. Gut. 2015 Apr; 64(4):528-30. PMID: 25342828.
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    268. Metildi CA, Felsen CN, Savariar EN, Nguyen QT, Kaushal S, Hoffman RM, Tsien RY, Bouvet M. Ratiometric activatable cell-penetrating peptides label pancreatic cancer, enabling fluorescence-guided surgery, which reduces metastases and recurrence in orthotopic mouse models. Ann Surg Oncol. 2015; 22(6):2082-7. PMID: 25319581; PMCID: PMC4400250.
    269. Zhang L, Wu C, Zhang Y, Liu F, Wang X, Zhao M, Hoffman RM. Comparison of efficacy and toxicity of traditional Chinese medicine (TCM) herbal mixture LQ and conventional chemotherapy on lung cancer metastasis and survival in mouse models. PLoS One. 2014; 9(10):e109814. PMID: 25286158; PMCID: PMC4186882.
    270. Uehara F, Miwa S, Tome Y, Hiroshima Y, Yano S, Yamamoto M, Efimova E, Matsumoto Y, Maehara H, Bouvet M, Kanaya F, Hoffman RM. Comparison of UVB and UVC effects on the DNA damage-response protein 53BP1 in human pancreatic cancer. J Cell Biochem. 2014 Oct; 115(10):1724-8. PMID: 24819034.
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    271. Yano S, Li S, Han Q, Tan Y, Bouvet M, Fujiwara T, Hoffman RM. Selective methioninase-induced trap of cancer cells in S/G2 phase visualized by FUCCI imaging confers chemosensitivity. Oncotarget. 2014 Sep 30; 5(18):8729-36. PMID: 25238266; PMCID: PMC4226717.
    272. Uehara F, Tome Y, Miwa S, Hiroshima Y, Yano S, Yamamoto M, Mii S, Maehara H, Bouvet M, Kanaya F, Hoffman RM. Osteosarcoma cells enhance angiogenesis visualized by color-coded imaging in the in vivo Gelfoam® assay. J Cell Biochem. 2014 Sep; 115(9):1490-4. PMID: 24590470; PMCID: PMC4107116.
    273. Miwa S, Yano S, Zhang Y, Matsumoto Y, Uehara F, Yamamoto M, Hiroshima Y, Kimura H, Hayashi K, Yamamoto N, Bouvet M, Tsuchiya H, Hoffman RM, Zhao M. Tumor-targeting Salmonella typhimurium A1-R prevents experimental human breast cancer bone metastasis in nude mice. Oncotarget. 2014 Aug 30; 5(16):7119-25. PMID: 25216526; PMCID: PMC4196188.
    274. Kolostova K, Zhang Y, Hoffman RM, Bobek V. In vitro culture and characterization of human lung cancer circulating tumor cells isolated by size exclusion from an orthotopic nude-mouse model expressing fluorescent protein. J Fluoresc. 2014 Sep; 24(5):1531-6. PMID: 25141982; PMCID: PMC4159578.
    275. Miwa S, Hiroshima Y, Yano S, Zhang Y, Matsumoto Y, Uehara F, Yamamoto M, Kimura H, Hayashi K, Bouvet M, Tsuchiya H, Hoffman RM. Fluorescence-guided surgery improves outcome in an orthotopic osteosarcoma nude-mouse model. J Orthop Res. 2014 Dec; 32(12):1596-601. PMID: 25138581; PMCID: PMC4198468.
    276. Hiroshima Y, Maawy A, Hassanein MK, Menen R, Momiyama M, Murakami T, Miwa S, Yamamoto M, Uehara F, Yano S, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM. The tumor-educated-macrophage increase of malignancy of human pancreatic cancer is prevented by zoledronic acid. PLoS One. 2014; 9(8):e103382. PMID: 25116261; PMCID: PMC4130525.
    277. Tome Y, Uehara F, Mii S, Yano S, Zhang L, Sugimoto N, Maehara H, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM. 3-dimensional tissue is formed from cancer cells in vitro on Gelfoam®, but not on Matrigel™. J Cell Biochem. 2014 Aug; 115(8):1362-7. PMID: 24497277.
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    278. Golubkov VS, Prigozhina NL, Zhang Y, Stoletov K, Lewis JD, Schwartz PE, Hoffman RM, Strongin AY. Protein-tyrosine pseudokinase 7 (PTK7) directs cancer cell motility and metastasis. J Biol Chem. 2014 Aug 29; 289(35):24238-49. PMID: 25006253; PMCID: PMC4148854.
    279. Hoffman RM, Zhao M. Methods for the development of tumor-targeting bacteria. Expert Opin Drug Discov. 2014 Jul; 9(7):741-50. PMID: 24949888.
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    280. Hiroshima Y, Zhao M, Maawy A, Zhang Y, Katz MH, Fleming JB, Uehara F, Miwa S, Yano S, Momiyama M, Suetsugu A, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM. Efficacy of Salmonella typhimurium A1-R versus chemotherapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX). J Cell Biochem. 2014 Jul; 115(7):1254-61. PMID: 24435915.
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    281. Kitamura T, Sakuma S, Shimosato M, Higashino H, Masaoka Y, Kataoka M, Yamashita S, Hiwatari K, Kumagai H, Morimoto N, Koike S, Tobita E, Hoffman RM, Gore JC, Pham W. Specificity of lectin-immobilized fluorescent nanospheres for colorectal tumors in a mouse model which better resembles the clinical disease. Contrast Media Mol Imaging. 2015 Mar-Apr; 10(2):135-43. PMID: 24976331; PMCID: PMC4277738.
    282. Hiroshima Y, Maawy A, Zhang Y, Sato S, Murakami T, Yamamoto M, Uehara F, Miwa S, Yano S, Momiyama M, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM. Fluorescence-guided surgery in combination with UVC irradiation cures metastatic human pancreatic cancer in orthotopic mouse models. PLoS One. 2014; 9(6):e99977. PMID: 24924955.
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    283. Mii S, Amoh Y, Katsuoka K, Hoffman RM. Comparison of nestin-expressing multipotent stem cells in the tongue fungiform papilla and vibrissa hair follicle. J Cell Biochem. 2014 Jun; 115(6):1070-6. PMID: 24142339.
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    284. Miwa S, Matsumoto Y, Hiroshima Y, Yano S, Uehara F, Yamamoto M, Zhang Y, Kimura H, Hayashi K, Yamamoto N, Bouvet M, Sugimoto N, Tsuchiya H, Hoffman RM. Fluorescence-guided surgery of prostate cancer bone metastasis. J Surg Res. 2014 Nov; 192(1):124-33. PMID: 24972740.
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    285. Maawy AA, Hiroshima Y, Zhang Y, Luiken GA, Hoffman RM, Bouvet M. Polyethylene glycol (PEG) linked to near infrared (NIR) dyes conjugated to chimeric anti-carcinoembryonic antigen (CEA) antibody enhances imaging of liver metastases in a nude-mouse model of human colon cancer. PLoS One. 2014; 9(5):e97965. PMID: 24859320; PMCID: PMC4032229.
    286. Li L, Wang M, Yu G, Chen P, Li H, Wei D, Zhu J, Xie L, Jia H, Shi J, Li C, Yao W, Wang Y, Gao Q, Jeong LS, Lee HW, Yu J, Hu F, Mei J, Wang P, Chu Y, Qi H, Yang M, Dong Z, Sun Y, Hoffman RM, Jia L. Overactivated neddylation pathway as a therapeutic target in lung cancer. J Natl Cancer Inst. 2014 Jun; 106(6):dju083. PMID: 24853380.
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    287. Yano S, Zhang Y, Miwa S, Tome Y, Hiroshima Y, Uehara F, Yamamoto M, Suetsugu A, Kishimoto H, Tazawa H, Zhao M, Bouvet M, Fujiwara T, Hoffman RM. Spatial-temporal FUCCI imaging of each cell in a tumor demonstrates locational dependence of cell cycle dynamics and chemoresponsiveness. Cell Cycle. 2014; 13(13):2110-9. PMID: 24811200; PMCID: PMC4111702.
    288. Metildi CA, Kaushal S, Luiken GA, Hoffman RM, Bouvet M. Advantages of fluorescence-guided laparoscopic surgery of pancreatic cancer labeled with fluorescent anti-carcinoembryonic antigen antibodies in an orthotopic mouse model. J Am Coll Surg. 2014 Jul; 219(1):132-41. PMID: 24768506; PMCID: PMC4065820.
    289. Aki R, Amoh Y, Bouvet M, Katsuoka K, Hoffman RM. Color-coded fluorescence imaging of lymph-node metastasis, angiogenesis, and its drug-induced inhibition. J Cell Biochem. 2014 Mar; 115(3):457-63. PMID: 24115019.
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    290. Metildi CA, Kaushal S, Pu M, Messer KA, Luiken GA, Moossa AR, Hoffman RM, Bouvet M. Fluorescence-guided surgery with a fluorophore-conjugated antibody to carcinoembryonic antigen (CEA), that highlights the tumor, improves surgical resection and increases survival in orthotopic mouse models of human pancreatic cancer. Ann Surg Oncol. 2014 Apr; 21(4):1405-11. PMID: 24499827; PMCID: PMC4334378.
    291. Hiroshima Y, Maawy A, Metildi CA, Zhang Y, Uehara F, Miwa S, Yano S, Sato S, Murakami T, Momiyama M, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM. Successful fluorescence-guided surgery on human colon cancer patient-derived orthotopic xenograft mouse models using a fluorophore-conjugated anti-CEA antibody and a portable imaging system. J Laparoendosc Adv Surg Tech A. 2014 Apr; 24(4):241-7. PMID: 24494971; PMCID: PMC4047993.
    292. Ongkeko WM, Burton D, Kiang A, Abhold E, Kuo SZ, Rahimy E, Yang M, Hoffman RM, Wang-Rodriguez J, Deftos LJ. Parathyroid hormone related-protein promotes epithelial-to-mesenchymal transition in prostate cancer. PLoS One. 2014; 9(1):e85803. PMID: 24465715; PMCID: PMC3899059.
    293. Yano S, Miwa S, Mii S, Hiroshima Y, Uehara F, Yamamoto M, Kishimoto H, Tazawa H, Bouvet M, Fujiwara T, Hoffman RM. Invading cancer cells are predominantly in G0/G1 resulting in chemoresistance demonstrated by real-time FUCCI imaging. Cell Cycle. 2014; 13(6):953-60. PMID: 24552821; PMCID: PMC3984318.
    294. Hoffman RM. Imageable clinically relevant mouse models of metastasis. Methods Mol Biol. 2014; 1070:141-70. PMID: 24092438.
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    295. Hoffman RM. Imaging metastatic cell trafficking at the cellular level in vivo with fluorescent proteins. Methods Mol Biol. 2014; 1070:171-9. PMID: 24092439.
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    296. Hoffman RM. Fluorescent angiogenesis models using gelfoam® implanted in transgenic mice expressing fluorescent proteins. Methods Mol Biol. 2014; 1135:213-22. PMID: 24510867.
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    297. Maawy AA, Hiroshima Y, Zhang Y, Luiken GA, Hoffman RM, Bouvet M. Specific tumor labeling enhanced by polyethylene glycol linkage of near infrared dyes conjugated to a chimeric anti-carcinoembryonic antigen antibody in a nude mouse model of human pancreatic cancer. J Biomed Opt. 2014; 19(10):101504. PMID: 24887695; PMCID: PMC4160999.
    298. Hoffman RM. Transgenic nude mice ubiquitously expressing fluorescent proteins for color-coded imaging of the tumor microenvironment. Methods Mol Biol. 2014; 1194:353-65. PMID: 25064114.
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    299. Yano S, Zhang Y, Zhao M, Hiroshima Y, Miwa S, Uehara F, Kishimoto H, Tazawa H, Bouvet M, Fujiwara T, Hoffman RM. Tumor-targeting Salmonella typhimurium A1-R decoys quiescent cancer cells to cycle as visualized by FUCCI imaging and become sensitive to chemotherapy. Cell Cycle. 2014; 13(24):3958-63. PMID: 25483077; PMCID: PMC4615054.
    300. Maawy AA, Hiroshima Y, Kaushal S, Luiken GA, Hoffman RM, Bouvet M. Comparison of a chimeric anti-carcinoembryonic antigen antibody conjugated with visible or near-infrared fluorescent dyes for imaging pancreatic cancer in orthotopic nude mouse models. J Biomed Opt. 2013 Dec; 18(12):126016. PMID: 24356647; PMCID: PMC3868446.
    301. Metildi CA, Kaushal S, Luiken GA, Talamini MA, Hoffman RM, Bouvet M. Fluorescently labeled chimeric anti-CEA antibody improves detection and resection of human colon cancer in a patient-derived orthotopic xenograft (PDOX) nude mouse model. J Surg Oncol. 2014 Apr; 109(5):451-8. PMID: 24249594; PMCID: PMC3962702.
    302. Hiroshima Y, Maawy A, Sato S, Murakami T, Uehara F, Miwa S, Yano S, Momiyama M, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM. Hand-held high-resolution fluorescence imaging system for fluorescence-guided surgery of patient and cell-line pancreatic tumors growing orthotopically in nude mice. J Surg Res. 2014 Apr; 187(2):510-7. PMID: 24373959; PMCID: PMC3959586.
    303. Kishimoto H, Momiyama M, Aki R, Kimura H, Suetsugu A, Bouvet M, Fujiwara T, Hoffman RM. Development of a clinically-precise mouse model of rectal cancer. PLoS One. 2013; 8(11):e79453. PMID: 24265772; PMCID: PMC3827128.
    304. Miwa S, Yano S, Tome Y, Sugimoto N, Hiroshima Y, Uehara F, Mii S, Kimura H, Hayashi K, Efimova EV, Fujiwara T, Tsuchiya H, Hoffman RM. Dynamic color-coded fluorescence imaging of the cell-cycle phase, mitosis, and apoptosis demonstrates how caffeine modulates cisplatinum efficacy. J Cell Biochem. 2013 Nov; 114(11):2454-60. PMID: 23696238.
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    305. Miwa S, Yano S, Hiroshima Y, Tome Y, Uehara F, Mii S, Efimova EV, Kimura H, Hayashi K, Tsuchiya H, Hoffman RM. Imaging UVC-induced DNA damage response in models of minimal cancer. J Cell Biochem. 2013 Nov; 114(11):2493-9. PMID: 23744630.
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    306. Liu F, Zhang C, Hoffman RM. Nestin-expressing stem cells from the hair follicle can differentiate into motor neurons and reduce muscle atrophy after transplantation to injured nerves. Tissue Eng Part A. 2014 Feb; 20(3-4):656-62. PMID: 24020586; PMCID: PMC3927650.
    307. He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M. Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell. 2013 Oct 10; 155(2):384-96. PMID: 24120137; PMCID: PMC4015514.
    308. Suetsugu A, Jiang P, Moriwaki H, Saji S, Bouvet M, Hoffman RM. Imaging nuclear - cytoplasm dynamics of cancer cells in the intravascular niche of live mice. Anticancer Res. 2013 Oct; 33(10):4229-36. PMID: 24122986.
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    309. Yano S, Tazawa H, Hashimoto Y, Shirakawa Y, Kuroda S, Nishizaki M, Kishimoto H, Uno F, Nagasaka T, Urata Y, Kagawa S, Hoffman RM, Fujiwara T. A genetically engineered oncolytic adenovirus decoys and lethally traps quiescent cancer stem-like cells in S/G2/M phases. Clin Cancer Res. 2013 Dec 01; 19(23):6495-505. PMID: 24081978.
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    310. Zhang L, Wu C, Zhang Y, Liu F, Zhao M, Bouvet M, Hoffman RM. Efficacy comparison of traditional Chinese medicine LQ versus gemcitabine in a mouse model of pancreatic cancer. J Cell Biochem. 2013 Sep; 114(9):2131-7. PMID: 23553901.
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    311. Tome Y, Kimura H, Maehara H, Sugimoto N, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM. High lung-metastatic variant of human osteosarcoma cells, selected by passage of lung metastasis in nude mice, is associated with increased expression of a(v)ß(3) integrin. Anticancer Res. 2013 Sep; 33(9):3623-7. PMID: 24023288.
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    312. Metildi CA, Tang CM, Kaushal S, Leonard SY, Magistri P, Tran Cao HS, Hoffman RM, Bouvet M, Sicklick JK. In vivo fluorescence imaging of gastrointestinal stromal tumors using fluorophore-conjugated anti-KIT antibody. Ann Surg Oncol. 2013 Dec; 20 Suppl 3:S693-700. PMID: 23943029; PMCID: PMC4127988.
    313. Hiroshima Y, Zhao M, Zhang Y, Maawy A, Hassanein MK, Uehara F, Miwa S, Yano S, Momiyama M, Suetsugu A, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM. Comparison of efficacy of Salmonella typhimurium A1-R and chemotherapy on stem-like and non-stem human pancreatic cancer cells. Cell Cycle. 2013 Sep 01; 12(17):2774-80. PMID: 23966167; PMCID: PMC3899191.
    314. Rashidi B, Moossa AR, Hoffman RM. Specific route mapping visualized with GFP of single-file streaming contralateral and systemic metastasis of Lewis lung carcinoma cells beginning within hours of orthotopic implantation [correction of implantion]. J Cell Biochem. 2013 Aug; 114(8):1738-43. PMID: 23444111.
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    315. Binder DC, Engels B, Arina A, Yu P, Slauch JM, Fu YX, Karrison T, Burnette B, Idel C, Zhao M, Hoffman RM, Munn DH, Rowley DA, Schreiber H. Antigen-specific bacterial vaccine combined with anti-PD-L1 rescues dysfunctional endogenous T cells to reject long-established cancer. Cancer Immunol Res. 2013 Aug; 1(2):123-33. PMID: 24455752; PMCID: PMC3895468.
    316. Snyder CS, Harrington AR, Kaushal S, Mose E, Lowy AM, Hoffman RM, Bouvet M. A dual-color genetically engineered mouse model for multispectral imaging of the pancreatic microenvironment. Pancreas. 2013 Aug; 42(6):952-8. PMID: 23648841.
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    317. Tome Y, Sugimoto N, Yano S, Momiyama M, Mii S, Maehara H, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM. Real-time imaging of av integrin molecular dynamics in osteosarcoma cells in vitro and in vivo. Anticancer Res. 2013 Aug; 33(8):3021-5. PMID: 23898055.
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    318. Uehara F, Tome Y, Reynoso J, Mii S, Yano S, Miwa S, Bouvet M, Maehara H, Kanaya F, Moossa AR, Hoffman RM. Color-coded imaging of spontaneous vessel anastomosis in vivo. Anticancer Res. 2013 Aug; 33(8):3041-5. PMID: 23898058.
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    319. Ke CC, Liu RS, Suetsugu A, Kimura H, Ho JH, Lee OK, Hoffman RM. In vivo fluorescence imaging reveals the promotion of mammary tumorigenesis by mesenchymal stromal cells. PLoS One. 2013; 8(7):e69658. PMID: 23936067; PMCID: PMC3723858.
    320. Hoffman RM. Tumor growth control with IDO-silencing Salmonella--letter. Cancer Res. 2013 Jul 15; 73(14):4591. PMID: 23832662.
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    321. Mii S, Duong J, Tome Y, Uchugonova A, Liu F, Amoh Y, Saito N, Katsuoka K, Hoffman RM. The role of hair follicle nestin-expressing stem cells during whisker sensory-nerve growth in long-term 3D culture. J Cell Biochem. 2013 Jul; 114(7):1674-84. PMID: 23444061.
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    322. Wolf K, Te Lindert M, Krause M, Alexander S, Te Riet J, Willis AL, Hoffman RM, Figdor CG, Weiss SJ, Friedl P. Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force. J Cell Biol. 2013 Jun 24; 201(7):1069-84. PMID: 23798731; PMCID: PMC3691458.
    323. Mii S, Uehara F, Yano S, Tran B, Miwa S, Hiroshima Y, Amoh Y, Katsuoka K, Hoffman RM. Nestin-Expressing Stem Cells Promote Nerve Growth in Long-Term 3-Dimensional Gelfoam®-Supported Histoculture. PLoS One. 2013; 8(6):e67153. PMID: 23840607; PMCID: PMC3686756.
    324. Hoffman RM. Stromal-cell and cancer-cell exosomes leading the metastatic exodus for the promised niche. Breast Cancer Res. 2013 Jun 18; 15(3):310. PMID: 23806092; PMCID: PMC3707067.
    325. Steinkamp MP, Winner KK, Davies S, Muller C, Zhang Y, Hoffman RM, Shirinifard A, Moses M, Jiang Y, Wilson BS. Ovarian tumor attachment, invasion, and vascularization reflect unique microenvironments in the peritoneum: insights from xenograft and mathematical models. Front Oncol. 2013; 3:97. PMID: 23730620; PMCID: PMC3656359.
    326. Zhang Y, Zhang N, Su S, Hoffman RM, Zhao M. Salmonella typhimurium A1-R tumor targeting in immunocompetent mice is enhanced by a traditional Chinese medicine herbal mixture. Anticancer Res. 2013 May; 33(5):1837-43. PMID: 23645728.
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    327. Lee SE, Bairstow SF, Werling JO, Chaubal MV, Lin L, Murphy MA, DiOrio JP, Gass J, Rabinow B, Wang X, Zhang Y, Yang Z, Hoffman RM. Paclitaxel nanosuspensions for targeted chemotherapy - nanosuspension preparation, characterization, and use. Pharm Dev Technol. 2014 Jun; 19(4):438-53. PMID: 23617261.
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    328. Metildi CA, Kaushal S, Hoffman RM, Bouvet M. In vivo serial selection of human pancreatic cancer cells in orthotopic mouse models produces high metastatic variants irrespective of Kras status. J Surg Res. 2013 Sep; 184(1):290-8. PMID: 23590868; PMCID: PMC3724759.
    329. Uehara F, Tome Y, Yano S, Miwa S, Mii S, Hiroshima Y, Bouvet M, Maehara H, Kanaya F, Hoffman RM. A color-coded imaging model of the interaction of av integrin-GFP expressed in osteosarcoma cells and RFP expressing blood vessels in Gelfoam® vascularized in vivo. Anticancer Res. 2013 Apr; 33(4):1361-6. PMID: 23564773.
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    330. Momiyama M, Suetsugu A, Kimura H, Chishima T, Bouvet M, Endo I, Hoffman RM. Dynamic subcellular imaging of cancer cell mitosis in the brain of live mice. Anticancer Res. 2013 Apr; 33(4):1367-71. PMID: 23564774.
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    331. Miwa S, Tome Y, Yano S, Hiroshima Y, Uehara F, Mii S, Kimura H, Hayashi K, Tsuchiya H, Bouvet M, Efimova EV, Hoffman RM. Single cell time-lapse imaging of focus formation by the DNA damage-response protein 53BP1 after UVC irradiation of human pancreatic cancer cells. Anticancer Res. 2013 Apr; 33(4):1373-7. PMID: 23564775.
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    332. Jung PS, Kim DY, Kim MB, Lee SW, Kim JH, Kim YM, Kim YT, Hoffman RM, Nam JH. Progression-free survival is accurately predicted in patients treated with chemotherapy for epithelial ovarian cancer by the histoculture drug response assay in a prospective correlative clinical trial at a single institution. Anticancer Res. 2013 Mar; 33(3):1029-34. PMID: 23482777.
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    333. Metildi CA, Hoffman RM, Bouvet M. Fluorescence-guided surgery and fluorescence laparoscopy for gastrointestinal cancers in clinically-relevant mouse models. Gastroenterol Res Pract. 2013; 2013:290634. PMID: 23533387; PMCID: PMC3590746.
    334. Shi Y, Tong M, Wu Y, Yang Z, Hoffman RM, Zhang Y, Tian Y, Qi M, Lin Y, Liu Y, Dai L, Sun Y, Wang Z. VEGF-C ShRNA inhibits pancreatic cancer growth and lymphangiogenesis in an orthotopic fluorescent nude mouse model. Anticancer Res. 2013 Feb; 33(2):409-17. PMID: 23393331.
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    335. Wu J, Ma R, Cao H, Wang Z, Jing C, Sun Y, Zhang Y, Yang Z, Hoffman RM, Tang J. Intraoperative imaging of metastatic lymph nodes using a fluorophore-conjugated antibody in a HER2/neu-expressing orthotopic breast cancer mouse model. Anticancer Res. 2013 Feb; 33(2):419-24. PMID: 23393332.
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    336. Momiyama M, Suetsugu A, Kimura H, Kishimoto H, Aki R, Yamada A, Sakurada H, Chishima T, Bouvet M, Endo I, Hoffman RM. Imaging the efficacy of UVC irradiation on superficial brain tumors and metastasis in live mice at the subcellular level. J Cell Biochem. 2013 Feb; 114(2):428-34. PMID: 22961687.
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    337. Stoletov K, Strnadel J, Zardouzian E, Momiyama M, Park FD, Kelber JA, Pizzo DP, Hoffman R, VandenBerg SR, Klemke RL. Role of connexins in metastatic breast cancer and melanoma brain colonization. J Cell Sci. 2013 Feb 15; 126(Pt 4):904-13. PMID: 23321642; PMCID: PMC3625812.
    338. Uchugonova A, Zhao M, Weinigel M, Zhang Y, Bouvet M, Hoffman RM, König K. Multiphoton tomography visualizes collagen fibers in the tumor microenvironment that maintain cancer-cell anchorage and shape. J Cell Biochem. 2013 Jan; 114(1):99-102. PMID: 22886742.
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    339. Hoffman RM. Fluorescent proteins as visible in vivo sensors. Prog Mol Biol Transl Sci. 2013; 113:389-402. PMID: 23244796.
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    340. Momiyama M, Suetsugu A, Chishima T, Bouvet M, Endo I, Hoffman RM. Subcellular real-time imaging of the efficacy of temozolomide on cancer cells in the brain of live mice. Anticancer Res. 2013 Jan; 33(1):103-6. PMID: 23267133.
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    341. Tome Y, Zhang Y, Momiyama M, Maehara H, Kanaya F, Tomita K, Tsuchiya H, Bouvet M, Hoffman RM, Zhao M. Primer dosing of S. typhimurium A1-R potentiates tumor-targeting and efficacy in immunocompetent mice. Anticancer Res. 2013 Jan; 33(1):97-102. PMID: 23267132.
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    342. Momiyama M, Hiroshima Y, Suetsugu A, Tome Y, Mii S, Yano S, Bouvet M, Chishima T, Endo I, Hoffman RM. Enhanced resection of orthotopic red-fluorescent-protein-expressing human glioma by fluorescence-guided surgery in nude mice. Anticancer Res. 2013 Jan; 33(1):107-11. PMID: 23267134.
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    343. Gros SJ, Kurschat N, Drenckhan A, Dohrmann T, Forberich E, Effenberger K, Reichelt U, Hoffman RM, Pantel K, Kaifi JT, Izbicki JR. Involvement of CXCR4 chemokine receptor in metastastic HER2-positive esophageal cancer. PLoS One. 2012; 7(10):e47287. PMID: 23082154; PMCID: PMC3474831.
    344. Momiyama M, Suetsugu A, Kimura H, Kishimoto H, Aki R, Yamada A, Sakurada H, Chishima T, Bouvet M, Bulgakova NN, Endo I, Hoffman RM. Fluorescent proteins enhance UVC PDT of cancer cells. Anticancer Res. 2012 Oct; 32(10):4327-30. PMID: 23060554.
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    345. Uchugonova A, Zhao M, Zhang Y, Weinigel M, König K, Hoffman RM. Cancer-cell killing by engineered Salmonella imaged by multiphoton tomography in live mice. Anticancer Res. 2012 Oct; 32(10):4331-7. PMID: 23060555.
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    346. Metildi CA, Kaushal S, Snyder CS, Hoffman RM, Bouvet M. Fluorescence-guided surgery of human colon cancer increases complete resection resulting in cures in an orthotopic nude mouse model. J Surg Res. 2013 Jan; 179(1):87-93. PMID: 23079571; PMCID: PMC3518733.
    347. Menen RS, Kaushal S, Snyder CS, Talamini MA, Hoffman RM, Bouvet M. Detection of colon cancer metastases with fluorescence laparoscopy in orthotopic nude mouse models. Arch Surg. 2012 Sep; 147(9):876-80. PMID: 22987187.
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    348. Tran Cao HS, Kaushal S, Metildi CA, Menen RS, Lee C, Snyder CS, Messer K, Pu M, Luiken GA, Talamini MA, Hoffman RM, Bouvet M. Tumor-specific fluorescence antibody imaging enables accurate staging laparoscopy in an orthotopic model of pancreatic cancer. Hepatogastroenterology. 2012 Sep; 59(118):1994-9. PMID: 22369743; PMCID: PMC4096574.
    349. Amoh Y, Mii S, Aki R, Hamada Y, Kawahara K, Hoffman RM, Katsuoka K. Multipotent nestin-expressing stem cells capable of forming neurons are located in the upper, middle and lower part of the vibrissa hair follicle. Cell Cycle. 2012 Sep 15; 11(18):3513-7. PMID: 22918245; PMCID: PMC3466560.
    350. Suetsugu A, Honma K, Saji S, Moriwaki H, Ochiya T, Hoffman RM. Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models. Adv Drug Deliv Rev. 2013 Mar; 65(3):383-90. PMID: 22921594.
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    351. Suetsugu A, Katz M, Fleming J, Truty M, Thomas R, Saji S, Moriwaki H, Bouvet M, Hoffman RM. Non-invasive fluorescent-protein imaging of orthotopic pancreatic-cancer-patient tumorgraft progression in nude mice. Anticancer Res. 2012 Aug; 32(8):3063-7. PMID: 22843874.
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    352. Bhatia S, Frangioni JV, Hoffman RM, Iafrate AJ, Polyak K. The challenges posed by cancer heterogeneity. Nat Biotechnol. 2012 Jul 10; 30(7):604-10. PMID: 22781679.
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    353. Zhang Y, Tome Y, Suetsugu A, Zhang L, Zhang N, Hoffman RM, Zhao M. Determination of the optimal route of administration of Salmonella typhimurium A1-R to target breast cancer in nude mice. Anticancer Res. 2012 Jul; 32(7):2501-8. PMID: 22753706.
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    354. Suetsugu A, Katz M, Fleming J, Truty M, Thomas R, Moriwaki H, Bouvet M, Saji S, Hoffman RM. Multi-color palette of fluorescent proteins for imaging the tumor microenvironment of orthotopic tumorgraft mouse models of clinical pancreatic cancer specimens. J Cell Biochem. 2012 Jul; 113(7):2290-5. PMID: 22573550; PMCID: PMC3566777.
    355. Menen R, Zhao M, Zhang L, Hassanein MK, Bobek V, Kolostova K, Bouvet M, Hoffman RM. Comparative chemosensitivity of circulating human prostate cancer cells and primary cancer cells. Anticancer Res. 2012 Jul; 32(7):2881-4. PMID: 22753751.
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    356. Menen RS, Hassanein MK, Momiyama M, Suetsugu A, Moossa AR, Hoffman RM, Bouvet M. Tumor-educated macrophages promote tumor growth and peritoneal metastasis in an orthotopic nude mouse model of human pancreatic cancer. In Vivo. 2012 Jul-Aug; 26(4):565-9. PMID: 22773569.
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    357. Hu M, Zhao M, An C, Yang M, Li Q, Zhang Y, Suetsugu A, Tome Y, Yano S, Fu Y, Hoffman RM, Hu K. Real-time imaging of apoptosis induction of human breast cancer cells by the traditional Chinese medicinal herb tubeimu. Anticancer Res. 2012 Jul; 32(7):2509-14. PMID: 22753707.
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    358. Hoffman RM. Bugging tumors. Cancer Discov. 2012 Jul; 2(7):588-90. PMID: 22787089; PMCID: PMC3706103.
    359. Metildi CA, Kaushal S, Hardamon CR, Snyder CS, Pu M, Messer KS, Talamini MA, Hoffman RM, Bouvet M. Fluorescence-guided surgery allows for more complete resection of pancreatic cancer, resulting in longer disease-free survival compared with standard surgery in orthotopic mouse models. J Am Coll Surg. 2012 Jul; 215(1):126-35; discussion 135-6. PMID: 22632917; PMCID: PMC3383387.
    360. Kelber JA, Reno T, Kaushal S, Metildi C, Wright T, Stoletov K, Weems JM, Park FD, Mose E, Wang Y, Hoffman RM, Lowy AM, Bouvet M, Klemke RL. KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer. Cancer Res. 2012 May 15; 72(10):2554-64. PMID: 22589274; PMCID: PMC3366503.
    361. Duong J, Mii S, Uchugonova A, Liu F, Moossa AR, Hoffman RM. Real-time confocal imaging of trafficking of nestin-expressing multipotent stem cells in mouse whiskers in long-term 3-D histoculture. In Vitro Cell Dev Biol Anim. 2012 May; 48(5):301-5. PMID: 22580909.
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    362. Menen R, Pinney E, Hassanein MK, Kolostova K, Bobek V, Suetsugu A, Zhang N, Bouvet M, Naughton GK, Hoffman RM. Inhibition of metastasis of circulating human prostate cancer cells in the chick embryo by an extracellular matrix produced by foreskin fibroblasts in culture. Anticancer Res. 2012 May; 32(5):1573-7. PMID: 22593434.
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    363. Abou-Elkacem L, Björn S, Doleschel D, Ntziachristos V, Schulz R, Hoffman RM, Kiessling F, Lederle W. High accuracy of mesoscopic epi-fluorescence tomography for non-invasive quantitative volume determination of fluorescent protein-expressing tumours in mice. Eur Radiol. 2012 Sep; 22(9):1955-62. PMID: 22544295.
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    364. Metildi CA, Kaushal S, Lee C, Hardamon CR, Snyder CS, Luiken GA, Talamini MA, Hoffman RM, Bouvet M. An LED light source and novel fluorophore combinations improve fluorescence laparoscopic detection of metastatic pancreatic cancer in orthotopic mouse models. J Am Coll Surg. 2012 Jun; 214(6):997-1007.e2. PMID: 22542065; PMCID: PMC3360832.
    365. Bobek V, Hoffman RM, Kolostova K. Site-specific cytomorphology of disseminated PC-3 prostate cancer cells visualized in vivo with fluorescent proteins. Diagn Cytopathol. 2013 May; 41(5):413-7. PMID: 22508666.
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    366. Wang M, Zhang X, Xiong X, Yang Z, Sun Y, Yang Z, Hoffman RM, Liu Y. Efficacy of the Chinese traditional medicinal herb Celastrus orbiculatus Thunb on human hepatocellular carcinoma in an orthothopic fluorescent nude mouse model. Anticancer Res. 2012 Apr; 32(4):1213-20. PMID: 22493351.
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    367. Suetsugu A, Katz M, Fleming J, Truty M, Thomas R, Saji S, Moriwaki H, Bouvet M, Hoffman RM. Imageable fluorescent metastasis resulting in transgenic GFP mice orthotopically implanted with human-patient primary pancreatic cancer specimens. Anticancer Res. 2012 Apr; 32(4):1175-80. PMID: 22493347.
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    368. Momiyama M, Kumamoto T, Suetsugu A, Kishimoto H, Chishima T, Tanaka K, Akiyama H, Ichikawa Y, Bouvet M, Endo I, Hoffman RM. Major liver resection stimulates stromal recruitment and metastasis compared with repeated minor resection. J Surg Res. 2012 Nov; 178(1):280-7. PMID: 22487397; PMCID: PMC3396724.
    369. Yamazaki T, Aoki K, Heike Y, Kim SW, Ochiya T, Wakeda T, Hoffman RM, Takaue Y, Nakagama H, Ikarashi Y. Real-time in vivo cellular imaging of graft-versus-host disease and its reaction to immunomodulatory reagents. Immunol Lett. 2012 May 30; 144(1-2):33-40. PMID: 22426442.
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    370. Kimura H, Tome Y, Momiyama M, Hayashi K, Tsuchiya H, Bouvet M, Hoffman RM. Imaging the inhibition by anti-ß1 integrin antibody of lung seeding of single osteosarcoma cells in live mice. Int J Cancer. 2012 Nov 01; 131(9):2027-33. PMID: 22323248.
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    371. Hoffman RM. Cellular and subcellular imaging in live mice using fluorescent proteins. Curr Pharm Biotechnol. 2012 Mar; 13(4):537-44. PMID: 22214502.
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    372. Momiyama M, Zhao M, Kimura H, Tran B, Chishima T, Bouvet M, Endo I, Hoffman RM. Inhibition and eradication of human glioma with tumor-targeting Salmonella typhimurium in an orthotopic nude-mouse model. Cell Cycle. 2012 Feb 01; 11(3):628-32. PMID: 22274398; PMCID: PMC3315098.
    373. Amoh Y, Hamada Y, Katsuoka K, Hoffman RM. In vivo imaging of nuclear-cytoplasmic deformation and partition during cancer cell death due to immune rejection. J Cell Biochem. 2012 Feb; 113(2):465-72. PMID: 21938737.
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    374. Suetsugu A, Hassanein MK, Reynoso J, Osawa Y, Nagaki M, Moriwaki H, Saji S, Bouvet M, Hoffman RM. The cyan fluorescent protein nude mouse as a host for multicolor-coded imaging models of primary and metastatic tumor microenvironments. Anticancer Res. 2012 Jan; 32(1):31-8. PMID: 22213285.
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    375. Hoffman RM, Bouvet M. Shedding (killer) light on tumors. Semin Thorac Cardiovasc Surg. 2012; 24(4):235-7. PMID: 23465668.
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    376. Yu Z, Zhou J, Hoffman RM. Lentivirus-based DsRed-2-transfected pancreatic cancer cells for deep in vivo imaging of metastatic disease. Methods Mol Biol. 2012; 872:69-83. PMID: 22700404.
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    377. Bouvet M, Hoffman RM. In vivo imaging of pancreatic cancer with fluorescent proteins in mouse models. Methods Mol Biol. 2012; 872:51-67. PMID: 22700403.
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    378. Hoffman RM. Subcellular imaging in vivo: the next GFP revolution. Methods Mol Biol. 2012; 872:255-63. PMID: 22700417.
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    379. Hoffman RM. Live cell imaging in live animals with fluorescent proteins. Methods Enzymol. 2012; 506:197-224. PMID: 22341226.
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    380. Zhao M, Suetsugu A, Ma H, Zhang L, Liu F, Zhang Y, Tran B, Hoffman RM. Efficacy against lung metastasis with a tumor-targeting mutant of Salmonella typhimurium in immunocompetent mice. Cell Cycle. 2012 Jan 01; 11(1):187-93. PMID: 22186786; PMCID: PMC3272237.
    381. Yamauchi K, Tome Y, Yamamoto N, Hayashi K, Kimura H, Tsuchiya H, Tomita K, Bouvet M, Hoffman RM. Color-coded real-time subcellular fluorescence imaging of the interaction between cancer and host cells in live mice. Anticancer Res. 2012 Jan; 32(1):39-43. PMID: 22213286.
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    382. Bakker GJ, Andresen V, Hoffman RM, Friedl P. Fluorescence lifetime microscopy of tumor cell invasion, drug delivery, and cytotoxicity. Methods Enzymol. 2012; 504:109-25. PMID: 22264531.
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    383. Hoffman RM. The preclinical discovery of bacterial therapy for the treatment of metastatic cancer with unique advantages. Expert Opin Drug Discov. 2012 Jan; 7(1):73-83. PMID: 22468895.
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    384. Hassanein MK, Suetsugu A, Saji S, Moriwaki H, Bouvet M, Moossa AR, Hoffman RM. Stem-like and non-stem human pancreatic cancer cells distinguished by morphology and metastatic behavior. J Cell Biochem. 2011 Dec; 112(12):3549-54. PMID: 21780159.
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    385. Sakuma S, Yamashita S, Hiwatari K, Hoffman RM, Pham W. Lectin-immobilized fluorescent nanospheres for targeting to colorectal cancer from a physicochemical perspective. Curr Drug Discov Technol. 2011 Dec 01; 8(4):367-78. PMID: 21644921.
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    386. Bouvet M, Hoffman RM. Glowing tumors make for better detection and resection. Sci Transl Med. 2011 Nov 23; 3(110):110fs10. PMID: 22116932.
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    387. Amoh Y, Aki R, Hamada Y, Niiyama S, Eshima K, Kawahara K, Sato Y, Tani Y, Hoffman RM, Katsuoka K. Nestin-positive hair follicle pluripotent stem cells can promote regeneration of impinged peripheral nerve injury. J Dermatol. 2012 Jan; 39(1):33-8. PMID: 22098554.
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    388. Hayashi K, Kimura H, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Kishimoto H, Hasegawa A, Bouvet M, Hoffman RM. Comparison of cancer-cell seeding, viability and deformation in the lung, muscle and liver, visualized by subcellular real-time imaging in the live mouse. Anticancer Res. 2011 Nov; 31(11):3665-72. PMID: 22110185.
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    389. Bobek V, Kolostova K, Pinterova D, Boubelik M, Gurlich R, Hoffman RM. Tail spontaneous metastatic mouse model: comparison of metastatic potential of orthotopic and heterotopic models imaged by GFP and RFP protein. In Vivo. 2011 Nov-Dec; 25(6):849-52. PMID: 22021676.
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    390. Murata T, Mizushima H, Chinen I, Moribe H, Yagi S, Hoffman RM, Kimura T, Yoshino K, Ueda Y, Enomoto T, Mekada E. HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers. Cancer Res. 2011 Nov 01; 71(21):6633-42. PMID: 22009535.
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    391. Menen RS, Pinney E, Kolostova K, Bobek V, Suetsugu A, Zhang N, Bouvet M, Hoffman RM. A rapid imageable in vivo metastasis assay for circulating tumor cells. Anticancer Res. 2011 Oct; 31(10):3125-8. PMID: 21965717.
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    392. Abou-Elkacem L, Gremse F, Barth S, Hoffman RM, Kiessling F, Lederle W. Comparison of µCT, MRI and optical reflectance imaging for assessing the growth of GFP/RFP-expressing tumors. Anticancer Res. 2011 Sep; 31(9):2907-13. PMID: 21868537.
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    393. Bobek V, Kolostova K, Pinterova D, Boubelik M, Hoffman RM. Development of new spontaneous metastatic heterotopic model of lewis lung carcinoma imaged by GFP expression. Cancer Invest. 2011 Dec; 29(10):692-5. PMID: 21877939.
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    394. Kishimoto H, Aki R, Urata Y, Bouvet M, Momiyama M, Tanaka N, Fujiwara T, Hoffman RM. Tumor-selective, adenoviral-mediated GFP genetic labeling of human cancer in the live mouse reports future recurrence after resection. Cell Cycle. 2011 Aug 15; 10(16):2737-41. PMID: 21785265; PMCID: PMC3219541.
    395. Uchugonova A, Duong J, Zhang N, König K, Hoffman RM. The bulge area is the origin of nestin-expressing pluripotent stem cells of the hair follicle. J Cell Biochem. 2011 Aug; 112(8):2046-50. PMID: 21465525.
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    396. Tran Cao HS, McElroy M, Kaushal S, Hoffman RM, Bouvet M. Imaging of the interaction of cancer cells and the lymphatic system. Adv Drug Deliv Rev. 2011 Sep 10; 63(10-11):886-9. PMID: 21718727; PMCID: PMC3164753.
    397. Tran Cao HS, Kaushal S, Menen RS, Metildi CA, Lee C, Snyder CS, Talamini MA, Hoffman RM, Bouvet M. Submillimeter-resolution fluorescence laparoscopy of pancreatic cancer in a carcinomatosis mouse model visualizes metastases not seen with standard laparoscopy. J Laparoendosc Adv Surg Tech A. 2011 Jul-Aug; 21(6):485-9. PMID: 21699431; PMCID: PMC3142857.
    398. Uchugonova A, Hoffman RM, Weinigel M, Koenig K. Watching stem cells in the skin of living mice noninvasively. Cell Cycle. 2011 Jun 15; 10(12):2017-20. PMID: 21558804.
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    399. Zhang Q, Bindokas V, Shen J, Fan H, Hoffman RM, Xing HR. Time-course imaging of therapeutic functional tumor vascular normalization by antiangiogenic agents. Mol Cancer Ther. 2011 Jul; 10(7):1173-84. PMID: 21586628.
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    400. Kolostova K, Pinterova D, Hoffman RM, Bobek V. Circulating human prostate cancer cells from an orthotopic mouse model rapidly captured by immunomagnetic beads and imaged by GFP expression. Anticancer Res. 2011 May; 31(5):1535-9. PMID: 21617207.
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    401. Hoffman RM. Tumor-seeking Salmonella amino acid auxotrophs. Curr Opin Biotechnol. 2011 Dec; 22(6):917-23. PMID: 21498066.
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    402. Grzesiak JJ, Tran Cao HS, Burton DW, Kaushal S, Vargas F, Clopton P, Snyder CS, Deftos LJ, Hoffman RM, Bouvet M. Knockdown of the ß(1) integrin subunit reduces primary tumor growth and inhibits pancreatic cancer metastasis. Int J Cancer. 2011 Dec 15; 129(12):2905-15. PMID: 21491421; PMCID: PMC3167925.
    403. Lin H, Liu F, Zhang C, Zhang Z, Kong Z, Zhang X, Hoffman RM. Characterization of nerve conduits seeded with neurons and Schwann cells derived from hair follicle neural crest stem cells. Tissue Eng Part A. 2011 Jul; 17(13-14):1691-8. PMID: 21338335.
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    404. Liu F, Uchugonova A, Kimura H, Zhang C, Zhao M, Zhang L, Koenig K, Duong J, Aki R, Saito N, Mii S, Amoh Y, Katsuoka K, Hoffman RM. The bulge area is the major hair follicle source of nestin-expressing pluripotent stem cells which can repair the spinal cord compared to the dermal papilla. Cell Cycle. 2011 Mar 01; 10(5):830-9. PMID: 21330787.
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    405. Suetsugu A, Osawa Y, Nagaki M, Saji S, Moriwaki H, Bouvet M, Hoffman RM. Imaging the recruitment of cancer-associated fibroblasts by liver-metastatic colon cancer. J Cell Biochem. 2011 Mar; 112(3):949-53. PMID: 21328469.
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    406. Yamamoto N, Tsuchiya H, Hoffman RM. Tumor imaging with multicolor fluorescent protein expression. Int J Clin Oncol. 2011 Apr; 16(2):84-91. PMID: 21347627.
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    407. Tan W, Zhang W, Strasner A, Grivennikov S, Cheng JQ, Hoffman RM, Karin M. Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling. Nature. 2011 Feb 24; 470(7335):548-53. PMID: 21326202; PMCID: PMC3166217.
    408. Bhattacharya A, Turowski SG, San Martin ID, Rajput A, Rustum YM, Hoffman RM, Seshadri M. Magnetic resonance and fluorescence-protein imaging of the anti-angiogenic and anti-tumor efficacy of selenium in an orthotopic model of human colon cancer. Anticancer Res. 2011 Feb; 31(2):387-93. PMID: 21378316; PMCID: PMC3129004.
    409. Soda Y, Marumoto T, Friedmann-Morvinski D, Soda M, Liu F, Michiue H, Pastorino S, Yang M, Hoffman RM, Kesari S, Verma IM. Transdifferentiation of glioblastoma cells into vascular endothelial cells. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4274-80. PMID: 21262804; PMCID: PMC3060261.
    410. Liu A, Fong A, Becket E, Yuan J, Tamae C, Medrano L, Maiz M, Wahba C, Lee C, Lee K, Tran KP, Yang H, Hoffman RM, Salih A, Miller JH. Selective advantage of resistant strains at trace levels of antibiotics: a simple and ultrasensitive color test for detection of antibiotics and genotoxic agents. Antimicrob Agents Chemother. 2011 Mar; 55(3):1204-10. PMID: 21199928; PMCID: PMC3067110.
    411. Hoffman RM. Nestin-driven green fluorescent protein as an imaging marker for nascent blood vessels in mouse models of cancer. Methods Mol Biol. 2011; 689:183-204. PMID: 21153793.
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    412. Bobek V, Kolostova K, Pinterova D, Kacprzak G, Adamiak J, Kolodziej J, Boubelik M, Kubecova M, Hoffman RM. A clinically relevant, syngeneic model of spontaneous, highly metastatic B16 mouse melanoma. Anticancer Res. 2010 Dec; 30(12):4799-803. PMID: 21187455.
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    413. Liu F, Zhang L, Hoffman RM, Zhao M. Vessel destruction by tumor-targeting Salmonella typhimurium A1-R is enhanced by high tumor vascularity. Cell Cycle. 2010 Nov 15; 9(22):4518-24. PMID: 21135579; PMCID: PMC3048048.
    414. Erten A, Hall D, Hoh C, Tran Cao HS, Kaushal S, Esener S, Hoffman RM, Bouvet M, Chen J, Kesari S, Makale M. Enhancing magnetic resonance imaging tumor detection with fluorescence intensity and lifetime imaging. J Biomed Opt. 2010 Nov-Dec; 15(6):066012. PMID: 21198186; PMCID: PMC3014225.
    415. Kimura H, Momiyama M, Tomita K, Tsuchiya H, Hoffman RM. Long-working-distance fluorescence microscope with high-numerical-aperture objectives for variable-magnification imaging in live mice from macro- to subcellular. J Biomed Opt. 2010 Nov-Dec; 15(6):066029. PMID: 21198203.
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    416. Tran Cao HS, Kaushal S, Snyder CS, Ongkeko WM, Hoffman RM, Bouvet M. Real-time imaging of tumor progression in a fluorescent orthotopic mouse model of thyroid cancer. Anticancer Res. 2010 Nov; 30(11):4415-22. PMID: 21115887; PMCID: PMC4453926.
    417. Suetsugu A, Osawa Y, Nagaki M, Moriwaki H, Saji S, Bouvet M, Hoffman RM. Simultaneous color-coded imaging to distinguish cancer "stem-like" and non-stem cells in the same tumor. J Cell Biochem. 2010 Nov 01; 111(4):1035-41. PMID: 20672309.
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    418. Amoh Y, Katsuoka K, Hoffman RM. The advantages of hair follicle pluripotent stem cells over embryonic stem cells and induced pluripotent stem cells for regenerative medicine. J Dermatol Sci. 2010 Dec; 60(3):131-7. PMID: 21036545.
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    419. Tsai MH, Aki R, Amoh Y, Hoffman RM, Katsuoka K, Kimura H, Lee C, Chang CH. GFP-fluorescence-guided UVC irradiation inhibits melanoma growth and angiogenesis in nude mice. Anticancer Res. 2010 Sep; 30(9):3291-4. PMID: 20944099.
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    420. Hoffman RM. Orthotopic mouse models expressing fluorescent proteins for cancer drug discovery. Expert Opin Drug Discov. 2010 Sep; 5(9):851-66. PMID: 22823260.
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    421. Kimura H, Lee C, Hayashi K, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Bouvet M, Hoffman RM. UV light killing efficacy of fluorescent protein-expressing cancer cells in vitro and in vivo. J Cell Biochem. 2010 Aug 15; 110(6):1439-46. PMID: 20506255.
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    422. Amoh Y, Li L, Katsuoka K, Hoffman RM. Embryonic development of hair follicle pluripotent stem (hfPS) cells. Med Mol Morphol. 2010 Jun; 43(2):123-7. PMID: 20683701.
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    423. Gros SJ, Kurschat N, Dohrmann T, Reichelt U, Dancau AM, Peldschus K, Adam G, Hoffman RM, Izbicki JR, Kaifi JT. Effective therapeutic targeting of the overexpressed HER-2 receptor in a highly metastatic orthotopic model of esophageal carcinoma. Mol Cancer Ther. 2010 Jul; 9(7):2037-45. PMID: 20606043.
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    424. Tran Cao HS, Bouvet M, Kaushal S, Keleman A, Romney E, Kim G, Fruehauf J, Imagawa DK, Hoffman RM, Katz MH. Metronomic gemcitabine in combination with sunitinib inhibits multisite metastasis and increases survival in an orthotopic model of pancreatic cancer. Mol Cancer Ther. 2010 Jul; 9(7):2068-78. PMID: 20606044; PMCID: PMC4383085.
    425. Erten A, Wrasidlo W, Scadeng M, Esener S, Hoffman RM, Bouvet M, Makale M. Magnetic resonance and fluorescence imaging of doxorubicin-loaded nanoparticles using a novel in vivo model. Nanomedicine. 2010 Dec; 6(6):797-807. PMID: 20599526; PMCID: PMC2980586.
    426. Wessels JT, Yamauchi K, Hoffman RM, Wouters FS. Advances in cellular, subcellular, and nanoscale imaging in vitro and in vivo. Cytometry A. 2010 Jul; 77(7):667-76. PMID: 20564541.
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    427. Ma H, Li X, Yang Z, Okuno S, Kawaguchi T, Yagi S, Bouvet M, Hoffman RM. High antimetastatic efficacy of MEN4901/T-0128, a novel camptothecin carboxymethyldextran conjugate. J Surg Res. 2011 Dec; 171(2):684-90. PMID: 20851421; PMCID: PMC3008337.
    428. Tran Cao HS, Kaushal S, Lee C, Snyder CS, Thompson KJ, Horgan S, Talamini MA, Hoffman RM, Bouvet M. Fluorescence laparoscopy imaging of pancreatic tumor progression in an orthotopic mouse model. Surg Endosc. 2011 Jan; 25(1):48-54. PMID: 20533064; PMCID: PMC3003784.
    429. Wang Y, Kelber JA, Tran Cao HS, Cantin GT, Lin R, Wang W, Kaushal S, Bristow JM, Edgington TS, Hoffman RM, Bouvet M, Yates JR, Klemke RL. Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected]. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):10920-5. PMID: 20534451; PMCID: PMC2890752.
    430. Zhang Q, Yang M, Shen J, Gerhold LM, Hoffman RM, Xing HR. The role of the intravascular microenvironment in spontaneous metastasis development. Int J Cancer. 2010 Jun 01; 126(11):2534-41. PMID: 19847811.
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    431. Gros SJ, Dohrmann T, Peldschus K, Schurr PG, Kaifi JT, Kalinina T, Reichelt U, Mann O, Strate TG, Adam G, Hoffman RM, Izbicki JR. Complementary use of fluorescence and magnetic resonance imaging of metastatic esophageal cancer in a novel orthotopic mouse model. Int J Cancer. 2010 Jun 01; 126(11):2671-81. PMID: 19847813.
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    432. Zhou J, Hu L, Yu Z, Zheng J, Yang D, Bouvet M, Hoffman RM. Marker expression in circulating cancer cells of pancreatic cancer patients. J Surg Res. 2011 Dec; 171(2):631-6. PMID: 20869080.
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    433. Drapeau C, Antarr D, Ma H, Yang Z, Tang L, Hoffman RM, Schaeffer DJ. Mobilization of bone marrow stem cells with StemEnhance improves muscle regeneration in cardiotoxin-induced muscle injury. Cell Cycle. 2010 May; 9(9):1819-23. PMID: 20404540.
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    434. Amoh Y, Hamada Y, Aki R, Kawahara K, Hoffman RM, Katsuoka K. Direct transplantation of uncultured hair-follicle pluripotent stem (hfPS) cells promotes the recovery of peripheral nerve injury. J Cell Biochem. 2010 May; 110(1):272-7. PMID: 20411592.
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    435. Aki R, Amoh Y, Li L, Katsuoka K, Hoffman RM. Nestin-expressing interfollicular blood vessel network contributes to skin transplant survival and wound healing. J Cell Biochem. 2010 May; 110(1):80-6. PMID: 20225276.
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    436. Tan Y, Xu M, Hoffman RM. Broad selective efficacy of recombinant methioninase and polyethylene glycol-modified recombinant methioninase on cancer cells In Vitro. Anticancer Res. 2010 Apr; 30(4):1041-6. PMID: 20530407.
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    437. Zhang Q, Fan H, Shen J, Hoffman RM, Xing HR. Human breast cancer cell lines co-express neuronal, epithelial, and melanocytic differentiation markers in vitro and in vivo. PLoS One. 2010 Mar 16; 5(3):e9712. PMID: 20300523; PMCID: PMC2838789.
    438. Arrach N, Cheng P, Zhao M, Santiviago CA, Hoffman RM, McClelland M. High-throughput screening for salmonella avirulent mutants that retain targeting of solid tumors. Cancer Res. 2010 Mar 15; 70(6):2165-70. PMID: 20231149; PMCID: PMC4103738.
    439. Tan Y, Xu M, Hoffman RM. Broad selective efficacy of rMETase and PEG-rMETase on cancer cells in vitro. Anticancer Res. 2010 Mar; 30(3):793-8. PMID: 20392998.
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    440. Kioi M, Vogel H, Schultz G, Hoffman RM, Harsh GR, Brown JM. Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. J Clin Invest. 2010 Mar; 120(3):694-705. PMID: 20179352; PMCID: PMC2827954.
    441. Murphy EA, Shields DJ, Stoletov K, Dneprovskaia E, McElroy M, Greenberg JI, Lindquist J, Acevedo LM, Anand S, Majeti BK, Tsigelny I, Saldanha A, Walsh B, Hoffman RM, Bouvet M, Klemke RL, Vogt PK, Arnold L, Wrasidlo W, Cheresh DA. Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4299-304. PMID: 20154271; PMCID: PMC2840076.
    442. Li L, Tang L, Baranov E, Yang M, Amoh Y, Katsuoka K, Hoffman RM. Selective induction of apoptosis in the hamster flank sebaceous gland organ by a topical liposome 5-alpha-reductase inhibitor: a treatment strategy for acne. J Dermatol. 2010 Feb; 37(2):156-62. PMID: 20175850.
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    443. Ishihara Y, Matsunaga K, Iijima H, Hasegawa G, Suzuki T, Sato A, Kobayashi T, Yang M, Hoffman RM. The combination of 5-FU, leucovorin and CPT-11 (FOLFIRI) prolongs survival through inhibition of metastasis in an orthotopic model of colon cancer. Anticancer Res. 2010 Feb; 30(2):403-8. PMID: 20332446.
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    444. Logan-Collins J, Thomas RM, Yu P, Jaquish D, Mose E, French R, Stuart W, McClaine R, Aronow B, Hoffman RM, Waltz SE, Lowy AM. Silencing of RON receptor signaling promotes apoptosis and gemcitabine sensitivity in pancreatic cancers. Cancer Res. 2010 Feb 01; 70(3):1130-40. PMID: 20103639; PMCID: PMC2943733.
    445. Hasegawa A, Hayashi K, Kishimoto H, Yang M, Tofukuji S, Suzuki K, Nakajima H, Hoffman RM, Shirai M, Nakayama T. Color-coded real-time cellular imaging of lung T-lymphocyte accumulation and focus formation in a mouse asthma model. J Allergy Clin Immunol. 2010 Feb; 125(2):461-468.e6. PMID: 20031194.
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    446. Sakuma S, Yano T, Masaoka Y, Kataoka M, Hiwatari K, Tachikawa H, Shoji Y, Kimura R, Ma H, Yang Z, Tang L, Hoffman RM, Yamashita S. Detection of early colorectal cancer imaged with peanut agglutinin-immobilized fluorescent nanospheres having surface poly(N-vinylacetamide) chains. Eur J Pharm Biopharm. 2010 Mar; 74(3):451-60. PMID: 20060903.
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    447. Kimura H, Hayashi K, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Kishimoto H, Bouvet M, Hoffman RM. Real-time imaging of single cancer-cell dynamics of lung metastasis. J Cell Biochem. 2010 Jan 01; 109(1):58-64. PMID: 19911396.
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    448. Amoh Y, Hoffman RM. Isolation and culture of hair follicle pluripotent stem (hfPS) cells and their use for nerve and spinal cord regeneration. Methods Mol Biol. 2010; 585:401-20. PMID: 19908019.
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    449. Kishimoto H, Urata Y, Tanaka N, Fujiwara T, Hoffman RM. Selective metastatic tumor labeling with green fluorescent protein and killing by systemic administration of telomerase-dependent adenoviruses. Mol Cancer Ther. 2009 Nov; 8(11):3001-8. PMID: 19887549.
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    450. Daenen LG, Shaked Y, Man S, Xu P, Voest EE, Hoffman RM, Chaplin DJ, Kerbel RS. Low-dose metronomic cyclophosphamide combined with vascular disrupting therapy induces potent antitumor activity in preclinical human tumor xenograft models. Mol Cancer Ther. 2009 Oct; 8(10):2872-81. PMID: 19825805; PMCID: PMC2782518.
    451. Tome Y, Tsuchiya H, Hayashi K, Yamauchi K, Sugimoto N, Kanaya F, Tomita K, Hoffman RM. In vivo gene transfer between interacting human osteosarcoma cell lines is associated with acquisition of enhanced metastatic potential. J Cell Biochem. 2009 Oct 01; 108(2):362-7. PMID: 19623575.
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    452. Folkins C, Shaked Y, Man S, Tang T, Lee CR, Zhu Z, Hoffman RM, Kerbel RS. Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal-derived factor 1. Cancer Res. 2009 Sep 15; 69(18):7243-51. PMID: 19738068; PMCID: PMC3409689.
    453. Matsuo Y, Raimondo M, Woodward TA, Wallace MB, Gill KR, Tong Z, Burdick MD, Yang Z, Strieter RM, Hoffman RM, Guha S. CXC-chemokine/CXCR2 biological axis promotes angiogenesis in vitro and in vivo in pancreatic cancer. Int J Cancer. 2009 Sep 01; 125(5):1027-37. PMID: 19431209.
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    454. Kishimoto H, Zhao M, Hayashi K, Urata Y, Tanaka N, Fujiwara T, Penman S, Hoffman RM. In vivo internal tumor illumination by telomerase-dependent adenoviral GFP for precise surgical navigation. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14514-7. PMID: 19706537; PMCID: PMC2732810.
    455. Amoh Y, Kanoh M, Niiyama S, Hamada Y, Kawahara K, Sato Y, Hoffman RM, Katsuoka K. Human hair follicle pluripotent stem (hfPS) cells promote regeneration of peripheral-nerve injury: an advantageous alternative to ES and iPS cells. J Cell Biochem. 2009 Aug 01; 107(5):1016-20. PMID: 19507228.
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    456. McElroy MK, Kaushal S, Tran Cao HS, Moossa AR, Talamini MA, Hoffman RM, Bouvet M. Upregulation of thrombospondin-1 and angiogenesis in an aggressive human pancreatic cancer cell line selected for high metastasis. Mol Cancer Ther. 2009 Jul; 8(7):1779-86. PMID: 19584238; PMCID: PMC3487474.
    457. Ma H, Das T, Pereira S, Yang Z, Zhao M, Mukerji P, Hoffman RM. Efficacy of dietary antioxidants combined with a chemotherapeutic agent on human colon cancer progression in a fluorescent orthotopic mouse model. Anticancer Res. 2009 Jul; 29(7):2421-6. PMID: 19596909.
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    458. Nagakura C, Hayashi K, Zhao M, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Bouvet M, Hoffman RM. Efficacy of a genetically-modified Salmonella typhimurium in an orthotopic human pancreatic cancer in nude mice. Anticancer Res. 2009 Jun; 29(6):1873-8. PMID: 19528442.
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    459. Tran Cao HS, Reynoso J, Yang M, Kimura H, Kaushal S, Snyder CS, Hoffman RM, Bouvet M. Development of the transgenic cyan fluorescent protein (CFP)-expressing nude mouse for "Technicolor" cancer imaging. J Cell Biochem. 2009 May 15; 107(2):328-34. PMID: 19306297; PMCID: PMC2833326.
    460. Hayashi K, Zhao M, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Hoffman RM. Cancer metastasis directly eradicated by targeted therapy with a modified Salmonella typhimurium. J Cell Biochem. 2009 Apr 15; 106(6):992-8. PMID: 19199339; PMCID: PMC2779055.
    461. Snyder CS, Kaushal S, Kono Y, Tran Cao HS, Hoffman RM, Bouvet M. Complementarity of ultrasound and fluorescence imaging in an orthotopic mouse model of pancreatic cancer. BMC Cancer. 2009 Apr 08; 9:106. PMID: 19351417; PMCID: PMC2679761.
    462. Yam C, Zhao M, Hayashi K, Ma H, Kishimoto H, McElroy M, Bouvet M, Hoffman RM. Monotherapy with a tumor-targeting mutant of S. typhimurium inhibits liver metastasis in a mouse model of pancreatic cancer. J Surg Res. 2010 Dec; 164(2):248-55. PMID: 19766244; PMCID: PMC2888721.
    463. Andresen V, Alexander S, Heupel WM, Hirschberg M, Hoffman RM, Friedl P. Infrared multiphoton microscopy: subcellular-resolved deep tissue imaging. Curr Opin Biotechnol. 2009 Feb; 20(1):54-62. PMID: 19324541.
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    464. Hoffman RM. Tumor-targeting amino acid auxotrophic Salmonella typhimurium. Amino Acids. 2009 Sep; 37(3):509-21. PMID: 19291366.
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    465. Hayashi K, Zhao M, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Kishimoto H, Bouvet M, Hoffman RM. Systemic targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma in nude mice with a tumor-selective strain of Salmonella typhimurium. Cell Cycle. 2009 Mar 15; 8(6):870-5. PMID: 19221501.
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    466. Tran Cao HS, Kimura H, Kaushal S, Snyder CS, Reynoso J, Hoffman RM, Bouvet M. The cyan fluorescent protein (CFP) transgenic mouse as a model for imaging pancreatic exocrine cells. JOP. 2009 Mar 09; 10(2):152-6. PMID: 19287108; PMCID: PMC4454444.
    467. Makale M, McElroy M, O'Brien P, Hoffman RM, Guo S, Bouvet M, Barnes L, Ingulli E, Cheresh D. Extended-working-distance multiphoton micromanipulation microscope for deep-penetration imaging in live mice and tissue. J Biomed Opt. 2009 Mar-Apr; 14(2):024032. PMID: 19405761; PMCID: PMC3098575.
    468. Yang M, Reynoso J, Bouvet M, Hoffman RM. A transgenic red fluorescent protein-expressing nude mouse for color-coded imaging of the tumor microenvironment. J Cell Biochem. 2009 Feb 01; 106(2):279-84. PMID: 19097136; PMCID: PMC2739131.
    469. Hoffman RM. Comment re: Preclinical model of spontaneous melanoma metastasis. Cancer Res. 2009 Jan 15; 69(2):719; author reply 720. PMID: 19147591.
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    470. Amoh Y, Kanoh M, Niiyama S, Kawahara K, Sato Y, Katsuoka K, Hoffman RM. Human and mouse hair follicles contain both multipotent and monopotent stem cells. Cell Cycle. 2009 Jan 01; 8(1):176-7. PMID: 19106614.
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    471. Drapeau C, Ma H, Yang Z, Tang L, Hoffman RM, Schaeffer DJ. The stem cell mobilizer StemEnhance does not promote tumor growth in an orthotopic model of human breast cancer. Anticancer Res. 2009 Jan; 29(1):443-7. PMID: 19331184.
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    472. Hoffman RM. Dual-color imaging of tumor angiogenesis. Methods Mol Biol. 2009; 515:45-61. PMID: 19378118.
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    473. Zhang C, Lv F, Zhou L, Li X, Wu XX, Hoffman RM. Effect of verapamil on the expression of EGFR and NM23 in A549 human lung cancer cells. Anticancer Res. 2009 Jan; 29(1):27-32. PMID: 19331130.
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    474. Amoh Y, Li L, Katsuoka K, Hoffman RM. Multipotent nestin-expressing hair follicle stem cells. J Dermatol. 2009 Jan; 36(1):1-9. PMID: 19207430.
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    475. Sakuma S, Yano T, Masaoka Y, Kataoka M, Hiwatari K, Tachikawa H, Shoji Y, Kimura R, Ma H, Yang Z, Tang L, Hoffman RM, Yamashita S. In vitro/in vivo biorecognition of lectin-immobilized fluorescent nanospheres for human colorectal cancer cells. J Control Release. 2009 Feb 20; 134(1):2-10. PMID: 19014984.
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    476. Mehta SR, Huang R, Yang M, Zhang XQ, Kolli B, Chang KP, Hoffman RM, Goto Y, Badaro R, Schooley RT. Real-time in vivo green fluorescent protein imaging of a murine leishmaniasis model as a new tool for Leishmania vaccine and drug discovery. Clin Vaccine Immunol. 2008 Dec; 15(12):1764-70. PMID: 18945882; PMCID: PMC2593180.
    477. Zhou J, Yu Z, Zhao S, Hu L, Zheng J, Yang D, Bouvet M, Hoffman RM. Lentivirus-based DsRed-2-transfected pancreatic cancer cells for deep in vivo imaging of metastatic disease. J Surg Res. 2009 Nov; 157(1):63-70. PMID: 19589544.
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    478. McElroy M, Kaushal S, Bouvet M, Hoffman RM. Color-coded imaging of splenocyte-pancreatic cancer cell interactions in the tumor microenvironment. Cell Cycle. 2008 Sep 15; 7(18):2916-21. PMID: 18787410; PMCID: PMC4383086.
    479. Hoffman RM. Imaging cancer dynamics in vivo at the tumor and cellular level with fluorescent proteins. Clin Exp Metastasis. 2009; 26(4):345-55. PMID: 18787963.
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    480. Al-Awadi F, Yang M, Tan Y, Han Q, Li S, Hoffman RM. Human tumor growth in nude mice is associated with decreased plasma cysteine and homocysteine. Anticancer Res. 2008 Sep-Oct; 28(5A):2541-4. PMID: 19035276.
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    481. Johnson TE, Luiken GA, Quigley MM, Xu M, Hoffman RM. In vivo fluorescence of medullary carcinoma of the thyroid: a technology with potential to improve visualization of malignant tissue at surgical resection. Ear Nose Throat J. 2008 Aug; 87(8):E1. PMID: 18712683.
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    482. Kaushal S, McElroy MK, Luiken GA, Talamini MA, Moossa AR, Hoffman RM, Bouvet M. Fluorophore-conjugated anti-CEA antibody for the intraoperative imaging of pancreatic and colorectal cancer. J Gastrointest Surg. 2008 Nov; 12(11):1938-50. PMID: 18665430; PMCID: PMC4396596.
    483. Hoffman RM. In vivo real-time imaging of nuclear-cytoplasmic dynamics of dormancy, proliferation and death of cancer cells. APMIS. 2008 Jul-Aug; 116(7-8):716-29. PMID: 18834414.
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    484. Arrach N, Zhao M, Porwollik S, Hoffman RM, McClelland M. Salmonella promoters preferentially activated inside tumors. Cancer Res. 2008 Jun 15; 68(12):4827-32. PMID: 18559530.
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    485. Amoh Y, Li L, Katsuoka K, Hoffman RM. Multipotent hair follicle stem cells promote repair of spinal cord injury and recovery of walking function. Cell Cycle. 2008 Jun 15; 7(12):1865-9. PMID: 18583926.
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    486. McElroy M, Kaushal S, Luiken GA, Talamini MA, Moossa AR, Hoffman RM, Bouvet M. Imaging of primary and metastatic pancreatic cancer using a fluorophore-conjugated anti-CA19-9 antibody for surgical navigation. World J Surg. 2008 Jun; 32(6):1057-66. PMID: 18264829; PMCID: PMC4378829.
    487. Wessels JT, Hoffman RM, Wouters FS. The use of transgenic fluorescent mouse strains, fluorescent protein coding vectors, and innovative imaging techniques in the life sciences. Cytometry A. 2008 Jun; 73(6):490-1. PMID: 18307256.
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    488. Hoffman RM, Li L. Targeted expression of GFP in the hair follicle using ex vivo viral transduction. J Vis Exp. 2008 Mar 17; (13). PMID: 19066571; PMCID: PMC2586868.
    489. Hoffman RM. Imaging In Mice With Fluorescent Proteins: From Macro To Subcellular. Sensors (Basel). 2008 Feb 22; 8(2):1157-1173. PMID: 27879758.
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    490. Duan JX, Jiao H, Kaizerman J, Stanton T, Evans JW, Lan L, Lorente G, Banica M, Jung D, Wang J, Ma H, Li X, Yang Z, Hoffman RM, Ammons WS, Hart CP, Matteucci M. Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs. J Med Chem. 2008 Apr 24; 51(8):2412-20. PMID: 18257544.
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    491. McElroy M, Hayashi K, Garmy-Susini B, Kaushal S, Varner JA, Moossa AR, Hoffman RM, Bouvet M. Fluorescent LYVE-1 antibody to image dynamically lymphatic trafficking of cancer cells in vivo. J Surg Res. 2009 Jan; 151(1):68-73. PMID: 18599080; PMCID: PMC2628480.
    492. Yamauchi K, Yang M, Hayashi K, Jiang P, Yamamoto N, Tsuchiya H, Tomita K, Moossa AR, Bouvet M, Hoffman RM. Induction of cancer metastasis by cyclophosphamide pretreatment of host mice: an opposite effect of chemotherapy. Cancer Res. 2008 Jan 15; 68(2):516-20. PMID: 18199547.
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    493. Han Q, Hoffman RM. Enzymatic assay for total plasma Cys. Nat Protoc. 2008; 3(11):1778-81. PMID: 18948977.
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    494. Amoh Y, Katsuoka K, Hoffman RM. Color-coded fluorescent protein imaging of angiogenesis: the AngioMouse models. Curr Pharm Des. 2008; 14(36):3810-9. PMID: 19128234.
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    495. Han Q, Hoffman RM. Nonradioactive enzymatic assay for plasma and serum vitamin B(6). Nat Protoc. 2008; 3(12):1815-9. PMID: 18989259.
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    496. McElroy M, Bouvet M, Hoffman RM. Chapter 2. Color-coded fluorescent mouse models of cancer cell interactions with blood vessels and lymphatics. Methods Enzymol. 2008; 445:27-52. PMID: 19022054.
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    497. Tan Y, Hoffman RM. A highly sensitive single-enzyme homocysteine assay. Nat Protoc. 2008; 3(9):1388-94. PMID: 18772865.
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    498. Hoffman RM. Recent advances on in vivo imaging with fluorescent proteins. Methods Cell Biol. 2008; 85:485-95. PMID: 18155476.
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    499. Hoffman RM. A better fluorescent protein for whole-body imaging. Trends Biotechnol. 2008 Jan; 26(1):1-4. PMID: 18037177.
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    500. Rajput A, Dominguez San Martin I, Rose R, Beko A, Levea C, Sharratt E, Mazurchuk R, Hoffman RM, Brattain MG, Wang J. Characterization of HCT116 human colon cancer cells in an orthotopic model. J Surg Res. 2008 Jun 15; 147(2):276-81. PMID: 17961596.
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    501. Hayashi K, Jiang P, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Moossa AR, Bouvet M, Hoffman RM. Real-time imaging of tumor-cell shedding and trafficking in lymphatic channels. Cancer Res. 2007 Sep 01; 67(17):8223-8. PMID: 17804736.
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    502. Yamauchi K, Yang M, Hayashi K, Jiang P, Yamamoto N, Tsuchiya H, Tomita K, Moossa AR, Bouvet M, Hoffman RM. Imaging of nucleolar dynamics during the cell cycle of cancer cells in live mice. Cell Cycle. 2007 Nov 01; 6(21):2706-8. PMID: 17912040.
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    503. Ammons WS, Wang JW, Yang Z, Tidmarsh GF, Hoffman RM. A novel alkylating agent, glufosfamide, enhances the activity of gemcitabine in vitro and in vivo. Neoplasia. 2007 Aug; 9(8):625-33. PMID: 17786181; PMCID: PMC1950432.
    504. Liu T, Ding Y, Xie W, Li Z, Bai X, Li X, Fang W, Ren C, Wang S, Hoffman RM, Yao K. An imageable metastatic treatment model of nasopharyngeal carcinoma. Clin Cancer Res. 2007 Jul 01; 13(13):3960-7. PMID: 17606730.
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    505. Guo XN, Rajput A, Rose R, Hauser J, Beko A, Kuropatwinski K, LeVea C, Hoffman RM, Brattain MG, Wang J. Mutant PIK3CA-bearing colon cancer cells display increased metastasis in an orthotopic model. Cancer Res. 2007 Jun 15; 67(12):5851-8. PMID: 17575153.
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    506. Zhao M, Geller J, Ma H, Yang M, Penman S, Hoffman RM. Monotherapy with a tumor-targeting mutant of Salmonella typhimurium cures orthotopic metastatic mouse models of human prostate cancer. Proc Natl Acad Sci U S A. 2007 Jun 12; 104(24):10170-4. PMID: 17548809; PMCID: PMC1891231.
    507. Yang M, Jiang P, Hoffman RM. Whole-body subcellular multicolor imaging of tumor-host interaction and drug response in real time. Cancer Res. 2007 Jun 01; 67(11):5195-200. PMID: 17545599.
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    508. Hayashi K, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Amoh Y, Hoffman RM, Bouvet M. Dual-color imaging of angiogenesis and its inhibition in bone and soft tissue sarcoma. J Surg Res. 2007 Jun 15; 140(2):165-70. PMID: 17418866; PMCID: PMC1994962.
    509. Hoffman RM. Noninvasive imaging for evaluation of the systemic delivery of capsid-modified adenovirus in an orthotopic model of advanced lung cancer. Cancer. 2007 Mar 15; 109(6):1213; author reply 1214. PMID: 17279581.
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    510. Ji Y, Hayashi K, Amoh Y, Tsuji K, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Bouvet M, Hoffman RM. The camptothecin derivative CPT-11 inhibits angiogenesis in a dual-color imageable orthotopic metastatic nude mouse model of human colon cancer. Anticancer Res. 2007 Mar-Apr; 27(2):713-8. PMID: 17465193.
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    511. Hoffman RM. The potential of nestin-expressing hair follicle stem cells in regenerative medicine. Expert Opin Biol Ther. 2007 Mar; 7(3):289-91. PMID: 17309321.
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    512. Amoh Y, Li L, Katsuoka K, Bouvet M, Hoffman RM. GFP-expressing vascularization of Gelfoam as a rapid in vivo assay of angiogenesis stimulators and inhibitors. Biotechniques. 2007 Mar; 42(3):294, 296, 298. PMID: 17390535.
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    513. Seitz G, Warmann SW, Armeanu S, Heitmann H, Ruck P, Hoffman RM, Fuchs J, Wessels JT. In vitro photodynamic therapy of childhood rhabdomyosarcoma. Int J Oncol. 2007 Mar; 30(3):615-20. PMID: 17273762.
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    514. Kudou D, Misaki S, Yamashita M, Tamura T, Takakura T, Yoshioka T, Yagi S, Hoffman RM, Takimoto A, Esaki N, Inagaki K. Structure of the antitumour enzyme L-methionine gamma-lyase from Pseudomonas putida at 1.8 A resolution. J Biochem. 2007 Apr; 141(4):535-44. PMID: 17289792.
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    515. Simberg D, Duza T, Park JH, Essler M, Pilch J, Zhang L, Derfus AM, Yang M, Hoffman RM, Bhatia S, Sailor MJ, Ruoslahti E. Biomimetic amplification of nanoparticle homing to tumors. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):932-6. PMID: 17215365; PMCID: PMC1783417.
    516. Hoffman RM. Subcellular imaging of cancer cells in live mice. Methods Mol Biol. 2007; 411:121-9. PMID: 18287642.
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    517. Bouvet M, Tsuji K, Yang M, Jiang P, Moossa AR, Hoffman RM. In vivo color-coded imaging of the interaction of colon cancer cells and splenocytes in the formation of liver metastases. Cancer Res. 2006 Dec 01; 66(23):11293-7. PMID: 17145875.
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    518. Amoh Y, Bouvet M, Li L, Tsuji K, Moossa AR, Katsuoka K, Hoffman RM. Visualization of nascent tumor angiogenesis in lung and liver metastasis by differential dual-color fluorescence imaging in nestin-linked-GFP mice. Clin Exp Metastasis. 2006; 23(7-8):315-22. PMID: 17136576.
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    519. Lukashev M, LePage D, Wilson C, Bailly V, Garber E, Lukashin A, Ngam-ek A, Zeng W, Allaire N, Perrin S, Xu X, Szeliga K, Wortham K, Kelly R, Bottiglio C, Ding J, Griffith L, Heaney G, Silverio E, Yang W, Jarpe M, Fawell S, Reff M, Carmillo A, Miatkowski K, Amatucci J, Crowell T, Prentice H, Meier W, Violette SM, Mackay F, Yang D, Hoffman R, Browning JL. Targeting the lymphotoxin-beta receptor with agonist antibodies as a potential cancer therapy. Cancer Res. 2006 Oct 01; 66(19):9617-24. PMID: 17018619.
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    520. Amoh Y, Nagakura C, Maitra A, Moossa AR, Katsuoka K, Hoffman RM, Bouvet M. Dual-color imaging of nascent angiogenesis and its inhibition in liver metastases of pancreatic cancer. Anticancer Res. 2006 Sep-Oct; 26(5A):3237-42. PMID: 17094435.
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    521. Hoffman RM. Real-time subcellular imaging in live animals: new visible targets for cancer drug discovery. IDrugs. 2006 Sep; 9(9):632-5. PMID: 16952071.
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    522. Berezovska OP, Glinskii AB, Yang Z, Li XM, Hoffman RM, Glinsky GV. Essential role for activation of the Polycomb group (PcG) protein chromatin silencing pathway in metastatic prostate cancer. Cell Cycle. 2006 Aug; 5(16):1886-901. PMID: 16963837.
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    523. Zhao M, Yang M, Ma H, Li X, Tan X, Li S, Yang Z, Hoffman RM. Targeted therapy with a Salmonella typhimurium leucine-arginine auxotroph cures orthotopic human breast tumors in nude mice. Cancer Res. 2006 Aug 01; 66(15):7647-52. PMID: 16885365.
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    524. Seitz G, Warmann SW, Fuchs J, Mau-Holzmann UA, Ruck P, Heitmann H, Hoffman RM, Mahrt J, Müller GA, Wessels JT. Visualization of xenotransplanted human rhabdomyosarcoma after transfection with red fluorescent protein. J Pediatr Surg. 2006 Aug; 41(8):1369-76. PMID: 16863839.
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    525. Amoh Y, Li L, Katsuoka K, Hoffman RM. Chemotherapy targets the hair-follicle vascular network but not the stem cells. J Invest Dermatol. 2007 Jan; 127(1):11-5. PMID: 16841031.
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    526. Jiang P, Yamauchi K, Yang M, Tsuji K, Xu M, Maitra A, Bouvet M, Hoffman RM. Tumor cells genetically labeled with GFP in the nucleus and RFP in the cytoplasm for imaging cellular dynamics. Cell Cycle. 2006 Jun; 5(11):1198-201. PMID: 16760659.
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    527. Hoffman RM. The hair follicle and its stem cells as drug delivery targets. Expert Opin Drug Deliv. 2006 May; 3(3):437-43. PMID: 16640502.
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    528. Yamauchi K, Yang M, Jiang P, Xu M, Yamamoto N, Tsuchiya H, Tomita K, Moossa AR, Bouvet M, Hoffman RM. Development of real-time subcellular dynamic multicolor imaging of cancer-cell trafficking in live mice with a variable-magnification whole-mouse imaging system. Cancer Res. 2006 Apr 15; 66(8):4208-14. PMID: 16618743.
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    529. Yang M, Burton DW, Geller J, Hillegonds DJ, Hastings RH, Deftos LJ, Hoffman RM. The bisphosphonate olpadronate inhibits skeletal prostate cancer progression in a green fluorescent protein nude mouse model. Clin Cancer Res. 2006 Apr 15; 12(8):2602-6. PMID: 16638872.
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    530. Tsuji K, Yang M, Jiang P, Maitra A, Kaushal S, Yamauchi K, Katz MH, Moossa AR, Hoffman RM, Bouvet M. Common bile duct injection as a novel method for establishing red fluorescent protein (RFP)-expressing human pancreatic cancer in nude mice. JOP. 2006 Mar 09; 7(2):193-9. PMID: 16525203.
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    531. Takakura T, Takimoto A, Notsu Y, Yoshida H, Ito T, Nagatome H, Ohno M, Kobayashi Y, Yoshioka T, Inagaki K, Yagi S, Hoffman RM, Esaki N. Physicochemical and pharmacokinetic characterization of highly potent recombinant L-methionine gamma-lyase conjugated with polyethylene glycol as an antitumor agent. Cancer Res. 2006 Mar 01; 66(5):2807-14. PMID: 16510603.
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    532. Amoh Y, Li L, Tsuji K, Moossa AR, Katsuoka K, Hoffman RM, Bouvet M. Dual-color imaging of nascent blood vessels vascularizing pancreatic cancer in an orthotopic model demonstrates antiangiogenesis efficacy of gemcitabine. J Surg Res. 2006 May 15; 132(2):164-9. PMID: 16500746.
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    533. Pilch J, Brown DM, Komatsu M, Järvinen TA, Yang M, Peters D, Hoffman RM, Ruoslahti E. Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds. Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8):2800-4. PMID: 16476999; PMCID: PMC1413849.
    534. Hoffman RM. The pluripotency of hair follicle stem cells. Cell Cycle. 2006 Feb; 5(3):232-3. PMID: 16410728.
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    535. Glinsky GV, Glinskii AB, Berezovskaya O, Smith BA, Jiang P, Li XM, Yang M, Hoffman RM. Dual-color-coded imaging of viable circulating prostate carcinoma cells reveals genetic exchange between tumor cells in vivo, contributing to highly metastatic phenotypes. Cell Cycle. 2006 Jan; 5(2):191-7. PMID: 16357534.
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    536. Hoffman RM, Yang M. Whole-body imaging with fluorescent proteins. Nat Protoc. 2006; 1(3):1429-38. PMID: 17406431.
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    537. Hoffman RM, Yang M. Subcellular imaging in the live mouse. Nat Protoc. 2006; 1(2):775-82. PMID: 17406307.
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    538. Hoffman RM, Yang M. Color-coded fluorescence imaging of tumor-host interactions. Nat Protoc. 2006; 1(2):928-35. PMID: 17406326.
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    539. Hoffman RM, Zhao M. Whole-body imaging of bacterial infection and antibiotic response. Nat Protoc. 2006; 1(6):2988-94. PMID: 17406559.
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    540. Tsuji K, Yamauchi K, Yang M, Jiang P, Bouvet M, Endo H, Kanai Y, Yamashita K, Moossa AR, Hoffman RM. Dual-color imaging of nuclear-cytoplasmic dynamics, viability, and proliferation of cancer cells in the portal vein area. Cancer Res. 2006 Jan 01; 66(1):303-6. PMID: 16397243.
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    541. Lademann J, Otberg N, Jacobi U, Hoffman RM, Blume-Peytavi U. Follicular penetration and targeting. J Investig Dermatol Symp Proc. 2005 Dec; 10(3):301-3. PMID: 16382687.
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    542. Amoh Y, Li L, Campillo R, Kawahara K, Katsuoka K, Penman S, Hoffman RM. Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17734-8. PMID: 16314569; PMCID: PMC1308908.
    543. Bouvet M, Spernyak J, Katz MH, Mazurchuk RV, Takimoto S, Bernacki R, Rustum YM, Moossa AR, Hoffman RM. High correlation of whole-body red fluorescent protein imaging and magnetic resonance imaging on an orthotopic model of pancreatic cancer. Cancer Res. 2005 Nov 01; 65(21):9829-33. PMID: 16267005.
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    544. Hoffman RM. The multiple uses of fluorescent proteins to visualize cancer in vivo. Nat Rev Cancer. 2005 Oct; 5(10):796-806. PMID: 16195751.
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    545. Yang M, Luiken G, Baranov E, Hoffman RM. Facile whole-body imaging of internal fluorescent tumors in mice with an LED flashlight. Biotechniques. 2005 Aug; 39(2):170, 172. PMID: 16116787.
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    546. Takakura T, Ito T, Yagi S, Notsu Y, Itakura T, Nakamura T, Inagaki K, Esaki N, Hoffman RM, Takimoto A. High-level expression and bulk crystallization of recombinant L-methionine gamma-lyase, an anticancer agent. Appl Microbiol Biotechnol. 2006 Mar; 70(2):183-92. PMID: 16012835.
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    547. Hoffman RM, Yang M. Dual-color, whole-body imaging in mice. Nat Biotechnol. 2005 Jul; 23(7):790; author reply 791. PMID: 16003354.
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    548. Hoffman RM. Advantages of multi-color fluorescent proteins for whole-body and in vivo cellular imaging. J Biomed Opt. 2005 Jul-Aug; 10(4):41202. PMID: 16178626.
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    549. Amoh Y, Yang M, Li L, Reynoso J, Bouvet M, Moossa AR, Katsuoka K, Hoffman RM. Nestin-linked green fluorescent protein transgenic nude mouse for imaging human tumor angiogenesis. Cancer Res. 2005 Jun 15; 65(12):5352-7. PMID: 15958583.
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    550. Yamauchi K, Yang M, Jiang P, Yamamoto N, Xu M, Amoh Y, Tsuji K, Bouvet M, Tsuchiya H, Tomita K, Moossa AR, Hoffman RM. Real-time in vivo dual-color imaging of intracapillary cancer cell and nucleus deformation and migration. Cancer Res. 2005 May 15; 65(10):4246-52. PMID: 15899816.
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    551. Amoh Y, Li L, Katsuoka K, Penman S, Hoffman RM. Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5530-4. PMID: 15802470; PMCID: PMC556262.
    552. Amoh Y, Li L, Yang M, Jiang P, Moossa AR, Katsuoka K, Hoffman RM. Hair follicle-derived blood vessels vascularize tumors in skin and are inhibited by Doxorubicin. Cancer Res. 2005 Mar 15; 65(6):2337-43. PMID: 15781648.
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    553. Berezovskaya O, Schimmer AD, Glinskii AB, Pinilla C, Hoffman RM, Reed JC, Glinsky GV. Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells. Cancer Res. 2005 Mar 15; 65(6):2378-86. PMID: 15781653.
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    554. Yang M, Jiang P, Yamamoto N, Li L, Geller J, Moossa AR, Hoffman RM. Real-time whole-body imaging of an orthotopic metastatic prostate cancer model expressing red fluorescent protein. Prostate. 2005 Mar 01; 62(4):374-9. PMID: 15389802.
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    555. Deftos LJ, Barken I, Burton DW, Hoffman RM, Geller J. Direct evidence that PTHrP expression promotes prostate cancer progression in bone. Biochem Biophys Res Commun. 2005 Feb 11; 327(2):468-72. PMID: 15629138.
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    556. Zhao M, Yang M, Li XM, Jiang P, Baranov E, Li S, Xu M, Penman S, Hoffman RM. Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):755-60. PMID: 15644448; PMCID: PMC545558.
    557. Hoffman RM. Orthotopic metastatic (MetaMouse) models for discovery and development of novel chemotherapy. Methods Mol Med. 2005; 111:297-322. PMID: 15911987.
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    558. Hoffman RM. In vivo cell biology of cancer cells visualized with fluorescent proteins. Curr Top Dev Biol. 2005; 70:121-44. PMID: 16338340.
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    559. Hoffman RM. Gene and stem cell therapy of the hair follicle. Methods Mol Biol. 2005; 289:437-48. PMID: 15502205.
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    560. Sun X, Tan Y, Yang Z, Li S, Hoffman RM. A rapid HPLC method for the measurement of ultra-low plasma methionine concentrations applicable to methionine depletion therapy. Anticancer Res. 2005 Jan-Feb; 25(1A):59-62. PMID: 15816519.
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    561. Yang M, Reynoso J, Jiang P, Li L, Moossa AR, Hoffman RM. Transgenic nude mouse with ubiquitous green fluorescent protein expression as a host for human tumors. Cancer Res. 2004 Dec 01; 64(23):8651-6. PMID: 15574773.
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    562. Yamamoto N, Yang M, Jiang P, Xu M, Yamauchi K, Tsuchiya H, Tomita K, Moossa AR, Hoffman RM. Color coding cancer cells with fluorescent proteins to visualize in vivo cellular interaction in metastatic colonies. Anticancer Res. 2004 Nov-Dec; 24(6):4067-72. PMID: 15736453.
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    563. Wang J, Yang M, Hoffman RM. Visualizing portal vein metastatic trafficking to the liver with green fluorescent protein-expressing tumor cells. Anticancer Res. 2004 Nov-Dec; 24(6):3699-702. PMID: 15736399.
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    564. Yang Z, Wang J, Lu Q, Xu J, Kobayashi Y, Takakura T, Takimoto A, Yoshioka T, Lian C, Chen C, Zhang D, Zhang Y, Li S, Sun X, Tan Y, Yagi S, Frenkel EP, Hoffman RM. PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methioninase in primates. Cancer Res. 2004 Sep 15; 64(18):6673-8. PMID: 15374983.
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    565. Han Q, Sun X, Xu M, Zhang N, Tang L, Tan Y, Hoffman RM. 3-Deazaadenosine, a stabilizer of whole-blood homocysteine content, does not interfere with the single-enzyme homocysteine assay while totally inhibiting the enzyme conversion homocysteine immunoassay. Clin Chem. 2004 Sep; 50(9):1703-4. PMID: 15331515.
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    566. Amoh Y, Li L, Yang M, Moossa AR, Katsuoka K, Penman S, Hoffman RM. Nascent blood vessels in the skin arise from nestin-expressing hair-follicle cells. Proc Natl Acad Sci U S A. 2004 Sep 07; 101(36):13291-5. PMID: 15331785; PMCID: PMC516562.
    567. Yang Z, Sun X, Li S, Tan Y, Wang X, Zhang N, Yagi S, Takakura T, Kobayashi Y, Takimoto A, Yoshioka T, Suginaka A, Frenkel EP, Hoffman RM. Circulating half-life of PEGylated recombinant methioninase holoenzyme is highly dose dependent on cofactor pyridoxal-5'-phosphate. Cancer Res. 2004 Aug 15; 64(16):5775-8. PMID: 15313919.
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    568. Li S, Yang Z, Sun X, Tan Y, Yagi S, Hoffman RM. Protein carboxyl amidation increases the potential extent of protein polyethylene glycol conjugation. Anal Biochem. 2004 Jul 15; 330(2):264-71. PMID: 15203332.
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    569. Han Q, Xu M, Tang L, Sun X, Zhang N, Tan X, Tan X, Tan Y, Hoffman RM. Homogeneous enzymatic colorimetric assay for total cysteine. Clin Chem. 2004 Jul; 50(7):1229-31. PMID: 15229150.
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    570. Hoffman RM. Imaging tumor angiogenesis with fluorescent proteins. APMIS. 2004 Jul-Aug; 112(7-8):441-9. PMID: 15563308.
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    571. Yamamoto N, Jiang P, Yang M, Xu M, Yamauchi K, Tsuchiya H, Tomita K, Wahl GM, Moossa AR, Hoffman RM. Cellular dynamics visualized in live cells in vitro and in vivo by differential dual-color nuclear-cytoplasmic fluorescent-protein expression. Cancer Res. 2004 Jun 15; 64(12):4251-6. PMID: 15205338.
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    572. Laakkonen P, Akerman ME, Biliran H, Yang M, Ferrer F, Karpanen T, Hoffman RM, Ruoslahti E. Antitumor activity of a homing peptide that targets tumor lymphatics and tumor cells. Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9381-6. PMID: 15197262; PMCID: PMC438985.
    573. Wang J, Yang M, Yagi S, Hoffman RM. Oral 5-FU is a more effective antimetastatic agent than UFT. Anticancer Res. 2004 May-Jun; 24(3a):1353-60. PMID: 15274295.
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    574. Yang Z, Wang J, Yoshioka T, Li B, Lu Q, Li S, Sun X, Tan Y, Yagi S, Frenkel EP, Hoffman RM. Pharmacokinetics, methionine depletion, and antigenicity of recombinant methioninase in primates. Clin Cancer Res. 2004 Mar 15; 10(6):2131-8. PMID: 15041734.
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    575. Glinsky GV, Glinskii AB, Stephenson AJ, Hoffman RM, Gerald WL. Gene expression profiling predicts clinical outcome of prostate cancer. J Clin Invest. 2004 Mar; 113(6):913-23. PMID: 15067324; PMCID: PMC362118.
    576. Katz MH, Bouvet M, Takimoto S, Spivack D, Moossa AR, Hoffman RM. Survival efficacy of adjuvant cytosine-analogue CS-682 in a fluorescent orthotopic model of human pancreatic cancer. Cancer Res. 2004 Mar 01; 64(5):1828-33. PMID: 14996746.
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    577. Hoffman RM. In vivo imaging with fluorescent proteins: the new cell biology. Acta Histochem. 2004; 106(2):77-87. PMID: 15147628.
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    578. Katz MH, Takimoto S, Spivack D, Moossa AR, Hoffman RM, Bouvet M. An imageable highly metastatic orthotopic red fluorescent protein model of pancreatic cancer. Clin Exp Metastasis. 2004; 21(1):7-12. PMID: 15065597.
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    579. Bobek V, Kolostova K, Pinterov D, Boubelik M, Jiang P, Yang M, Hoffman RM. Syngeneic lymph-node-targeting model of green fluorescent protein-expressing Lewis lung carcinoma. Clin Exp Metastasis. 2004; 21(8):705-8. PMID: 16035615.
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    580. Bobek V, Plachy J, Pinterova D, Kolostova K, Boubelik M, Jiang P, Yang M, Hoffman RM. Development of a green fluorescent protein metastatic-cancer chick-embryo drug-screen model. Clin Exp Metastasis. 2004; 21(4):347-52. PMID: 15554391.
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    581. Sun X, Yang Z, Li S, Tan Y, Zhang N, Wang X, Yagi S, Yoshioka T, Takimoto A, Mitsushima K, Suginaka A, Frenkel EP, Hoffman RM. In vivo efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol conjugation and pyridoxal 5'-phosphate supplementation. Cancer Res. 2003 Dec 01; 63(23):8377-83. PMID: 14678999.
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    582. Yamamoto N, Yang M, Jiang P, Xu M, Tsuchiya H, Tomita K, Moossa AR, Hoffman RM. Determination of clonality of metastasis by cell-specific color-coded fluorescent-protein imaging. Cancer Res. 2003 Nov 15; 63(22):7785-90. PMID: 14633704.
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    583. Yang M, Li L, Jiang P, Moossa AR, Penman S, Hoffman RM. Dual-color fluorescence imaging distinguishes tumor cells from induced host angiogenic vessels and stromal cells. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14259-62. PMID: 14614130; PMCID: PMC283579.
    584. Mitsiades CS, Mitsiades NS, Bronson RT, Chauhan D, Munshi N, Treon SP, Maxwell CA, Pilarski L, Hideshima T, Hoffman RM, Anderson KC. Fluorescence imaging of multiple myeloma cells in a clinically relevant SCID/NOD in vivo model: biologic and clinical implications. Cancer Res. 2003 Oct 15; 63(20):6689-96. PMID: 14583463.
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    585. Katz MH, Bouvet M, Takimoto S, Spivack D, Moossa AR, Hoffman RM. Selective antimetastatic activity of cytosine analog CS-682 in a red fluorescent protein orthotopic model of pancreatic cancer. Cancer Res. 2003 Sep 01; 63(17):5521-5. PMID: 14500389.
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    586. Goodison S, Kawai K, Hihara J, Jiang P, Yang M, Urquidi V, Hoffman RM, Tarin D. Prolonged dormancy and site-specific growth potential of cancer cells spontaneously disseminated from nonmetastatic breast tumors as revealed by labeling with green fluorescent protein. Clin Cancer Res. 2003 Sep 01; 9(10 Pt 1):3808-14. PMID: 14506175.
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    587. Li L, Mignone J, Yang M, Matic M, Penman S, Enikolopov G, Hoffman RM. Nestin expression in hair follicle sheath progenitor cells. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):9958-61. PMID: 12904579; PMCID: PMC187900.
    588. Katz MH, Spivack DE, Takimoto S, Fang B, Burton DW, Moossa AR, Hoffman RM, Bouvet M. Gene therapy of pancreatic cancer with green fluorescent protein and tumor necrosis factor-related apoptosis-inducing ligand fusion gene expression driven by a human telomerase reverse transcriptase promoter. Ann Surg Oncol. 2003 Aug; 10(7):762-72. PMID: 12900367.
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    589. Glinskii AB, Smith BA, Jiang P, Li XM, Yang M, Hoffman RM, Glinsky GV. Viable circulating metastatic cells produced in orthotopic but not ectopic prostate cancer models. Cancer Res. 2003 Jul 15; 63(14):4239-43. PMID: 12874032.
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    590. Katz MH, Takimoto S, Spivack D, Moossa AR, Hoffman RM, Bouvet M. A novel red fluorescent protein orthotopic pancreatic cancer model for the preclinical evaluation of chemotherapeutics. J Surg Res. 2003 Jul; 113(1):151-60. PMID: 12943825.
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    591. Flowers JL, Hoffman RM, Driscoll TA, Wall ME, Wani MC, Manikumar G, Friedman HS, Dewhirst M, Colvin OM, Adams DJ. The activity of camptothecin analogues is enhanced in histocultures of human tumors and human tumor xenografts by modulation of extracellular pH. Cancer Chemother Pharmacol. 2003 Sep; 52(3):253-61. PMID: 12783198.
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    592. Tan Y, Sun X, Tang L, Zhang N, Han Q, Xu M, Tan X, Tan X, Hoffman RM. Automated enzymatic assay for homocysteine. Clin Chem. 2003 Jun; 49(6 Pt 1):1029-30. PMID: 12766025.
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    593. Wu M, Mazurchuk R, Chaudhary ND, Spernyak J, Veith J, Pera P, Greco W, Hoffman RM, Kobayashi T, Bernacki RJ. High-resolution magnetic resonance imaging of the efficacy of the cytosine analogue 1-[2-C-cyano-2-deoxy-beta-D-arabino-pentofuranosyl]-N(4)-palmitoyl cytosine (CS-682) in a liver-metastasis athymic nude mouse model. Cancer Res. 2003 May 15; 63(10):2477-82. PMID: 12750269.
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    594. Hoffman RM. Immune reactions in skin and hair follicle gene therapy. Mol Ther. 2003 Mar; 7(3):294-5. PMID: 12668124.
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    595. Li S, Yang Z, Sun X, Tan Y, Yagi S, Hoffman RM. A simultaneous colorimetric assay of free and protein-coupled polyethylene glycol. Anal Biochem. 2003 Feb 15; 313(2):335-7. PMID: 12605873.
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    596. Yamamoto N, Yang M, Jiang P, Xu M, Tsuchiya H, Tomita K, Moossa AR, Hoffman RM. Real-time imaging of individual fluorescent-protein color-coded metastatic colonies in vivo. Clin Exp Metastasis. 2003; 20(7):633-8. PMID: 14669794.
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    597. Sun FX, Tohgo A, Bouvet M, Yagi S, Nassirpour R, Moossa AR, Hoffman RM. Efficacy of camptothecin analog DX-8951f (Exatecan Mesylate) on human pancreatic cancer in an orthotopic metastatic model. Cancer Res. 2003 Jan 01; 63(1):80-5. PMID: 12517781.
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    598. Hoffman RM. Metastatic orthotopic mouse models of lung cancer. Methods Mol Med. 2003; 74:457-64. PMID: 12415714.
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    599. Hoffman RM. PEG-methioninase. Adv Exp Med Biol. 2003; 519:69-79. PMID: 12675209.
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    600. Stoller JK, Hoffman RM, White RD, Mee RB. Anomalous hepatic venous drainage into the left atrium: an unusual cause of hypoxemia. Respir Care. 2003 Jan; 48(1):58-62. PMID: 12556263.
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    601. Yamamoto N, Yang M, Jiang P, Tsuchiya H, Tomita K, Moossa AR, Hoffman RM. Real-time GFP imaging of spontaneous HT-1080 fibrosarcoma lung metastases. Clin Exp Metastasis. 2003; 20(2):181-5. PMID: 12705639.
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    602. Wang JW, Yang M, Wang X, Sun FX, Li XM, Yagi S, Hoffman RM. Antimetastatic efficacy of oral 5-FU imaged by green fluorescent protein in real time. Anticancer Res. 2003 Jan-Feb; 23(1A):1-6. PMID: 12680187.
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    603. Saito N, Zhao M, Li L, Baranov E, Yang M, Ohta Y, Katsuoka K, Penman S, Hoffman RM. High efficiency genetic modification of hair follicles and growing hair shafts. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):13120-4. PMID: 12232045; PMCID: PMC130596.
    604. Vietor I, Vadivelu SK, Wick N, Hoffman R, Cotten M, Seiser C, Fialka I, Wunderlich W, Haase A, Korinkova G, Brosch G, Huber LA. TIS7 interacts with the mammalian SIN3 histone deacetylase complex in epithelial cells. EMBO J. 2002 Sep 02; 21(17):4621-31. PMID: 12198164; PMCID: PMC125408.
    605. Han Q, Xu M, Tang L, Tan X, Tan X, Tan Y, Hoffman RM. Homogeneous, nonradioactive, enzymatic assay for plasma pyridoxal 5-phosphate. Clin Chem. 2002 Sep; 48(9):1560-4. PMID: 12194934.
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    606. Hoffman R. Green fluorescent protein imaging of tumour growth, metastasis, and angiogenesis in mouse models. Lancet Oncol. 2002 Sep; 3(9):546-56. PMID: 12217792.
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    607. Machover D, Zittoun J, Saffroy R, Broët P, Giraudier S, Magnaldo T, Goldschmidt E, Debuire B, Orrico M, Tan Y, Mishal Z, Chevallier O, Tonetti C, Jouault H, Ulusakarya A, Tanguy ML, Metzger G, Hoffman RM. Treatment of cancer cells with methioninase produces DNA hypomethylation and increases DNA synthesis. Cancer Res. 2002 Aug 15; 62(16):4685-9. PMID: 12183426.
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    608. Pirocanac EC, Nassirpour R, Yang M, Wang J, Nardin SR, Gu J, Fang B, Moossa AR, Hoffman RM, Bouvet M. Bax-induction gene therapy of pancreatic cancer. J Surg Res. 2002 Aug; 106(2):346-51. PMID: 12175991.
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    609. Zhou JH, Rosser CJ, Tanaka M, Yang M, Baranov E, Hoffman RM, Benedict WF. Visualizing superficial human bladder cancer cell growth in vivo by green fluorescent protein expression. Cancer Gene Ther. 2002 Aug; 9(8):681-6. PMID: 12136429.
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    610. Hoffman RM. Watching real-time metastasis in vivo. Trends Mol Med. 2002 Jul; 8(7):354-5. PMID: 12114116.
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    611. Schmitt CA, Fridman JS, Yang M, Lee S, Baranov E, Hoffman RM, Lowe SW. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell. 2002 May 03; 109(3):335-46. PMID: 12015983.
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    612. Singh B, Li R, Xu L, Poluri A, Patel S, Shaha AR, Pfister D, Sherman E, Goberdhan A, Hoffman RM, Shah J. Prediction of survival in patients with head and neck cancer using the histoculture drug response assay. Head Neck. 2002 May; 24(5):437-42. PMID: 12001073.
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    613. Hoffman RM. Green fluorescent protein imaging of tumor cells in mice. Lab Anim (NY). 2002 Apr; 31(4):34-41. PMID: 11927960.
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    614. Schmitt CA, Fridman JS, Yang M, Baranov E, Hoffman RM, Lowe SW. Dissecting p53 tumor suppressor functions in vivo. Cancer Cell. 2002 Apr; 1(3):289-98. PMID: 12086865.
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    615. Bouvet M, Nardin SR, Burton DW, Lee NC, Yang M, Wang X, Baranov E, Behling C, Moossa AR, Hoffman RM, Deftos LJ. Parathyroid hormone-related protein as a novel tumor marker in pancreatic adenocarcinoma. Pancreas. 2002 Apr; 24(3):284-90. PMID: 11893937.
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    616. Yang M, Baranov E, Wang JW, Jiang P, Wang X, Sun FX, Bouvet M, Moossa AR, Penman S, Hoffman RM. Direct external imaging of nascent cancer, tumor progression, angiogenesis, and metastasis on internal organs in the fluorescent orthotopic model. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3824-9. PMID: 11891294; PMCID: PMC122608.
    617. Bouvet M, Wang J, Nardin SR, Nassirpour R, Yang M, Baranov E, Jiang P, Moossa AR, Hoffman RM. Real-time optical imaging of primary tumor growth and multiple metastatic events in a pancreatic cancer orthotopic model. Cancer Res. 2002 Mar 01; 62(5):1534-40. PMID: 11888932.
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    618. Kamiyama M, Ichikawa Y, Ishikawa T, Chishima T, Hasegawa S, Hamaguchi Y, Nagashima Y, Miyagi Y, Mitsuhashi M, Hyndman D, Hoffman RM, Ohki S, Shimada H. VEGF receptor antisense therapy inhibits angiogenesis and peritoneal dissemination of human gastric cancer in nude mice. Cancer Gene Ther. 2002 Feb; 9(2):197-201. PMID: 11857038.
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    619. Tripodi A, Chantarangkul V, Tan Y, Hoffman RM, Cattaneo M. Evaluation of an enzymatic method to measure total homocysteine in plasma. Thromb Haemost. 2002 Jan; 87(1):172-3. PMID: 11848450.
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    620. Li X, Wang J, An Z, Yang M, Baranov E, Jiang P, Sun F, Moossa AR, Hoffman RM. Optically imageable metastatic model of human breast cancer. Clin Exp Metastasis. 2002; 19(4):347-50. PMID: 12090475.
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    621. Hoffman RM. Whole-body fluorescence imaging with green fluorescence protein. Methods Mol Biol. 2002; 183:135-48. PMID: 12136749.
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