Robert Hoffman

Title(s)Recall Faculty, Surgery
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Overview
    Research Overview
    Our research program centers on cancer with the ultimate goal of developing a general cure.

    Research Topics
    - Angiogenesis
    - Cancer
    - Cell Biology
    - Development
    - Drug Delivery
    - Genetics
    - Genomics
    - Regeneration/Stem Cells
    - Translational Research

    Collapse Research 
    Collapse Research Activities and Funding
    Establishment of a patient-like mouse models of soft-tissue sarcoma sub-types
    NIH R43CA213649Dec 15, 2016 - Nov 30, 2017
    Role: Principal Investigator
    METHIONINE DEPENDENCE, METHYLATION AND ONCOGENESIS
    NIH K04CA000804Sep 1, 1982 - Aug 31, 1987
    Role: Principal Investigator
    METHIONINE DEPENDENCE, A METABOLIC MARKER IN CANCER
    NIH R01CA027564Sep 1, 1979 - Nov 30, 1993
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Complete Response (CR) in a Previously-progressing Chronic Lymphocytic Leukemia (CLL) Patient Treated With Methionine Restriction in Combination With First-line Chemotherapy. Cancer Diagn Progn. 2025 Jan-Feb; 5(1):21-26. Morinaga S, Han Q, Mizuta K, Kang BM, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39758229; PMCID: PMC11696344.
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    2. Elevated-c-MYC-expressing Fibrosarcoma Cells With Acquired Gemcitabine Resistance Remain Sensitive to Recombinant Methioninase: A Potential Clinical Strategy for a Recalcitrant Disease. Cancer Diagn Progn. 2025 Jan-Feb; 5(1):8-14. Morinaga S, Han Q, Mizuta K, Kang BM, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39758233; PMCID: PMC11696348.
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    3. Prostate Cancer Patient With Lymph-node Metastasis Treated Only With Methionine Restriction Has Stable Disease for Two Years Demonstrated With PET/CT and PSMA-PET Scanning and PSA Testing. Cancer Diagn Progn. 2025 Jan-Feb; 5(1):27-31. Morinaga S, Han Q, Mizuta K, Kang BM, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39758238; PMCID: PMC11696347.
      View in: PubMed   Mentions:
    4. Immune Stress-induced Tumor Mutation Burden and Neoantigen Expression in 4T1 Mammary Cancer Cells: A Potential Mechanism for Long-term Survival in Patients Treated With Immune Checkpoint Inhibitors. Cancer Genomics Proteomics. 2025 Jan-Feb; 22(1):1-12. Ishiguro T, Takeda K, Takayanagi D, Mura E, Suzuki R, Tsurui T, Iriguchi N, Hirasawa Y, Ohkuma R, Shimokawa M, Ariizumi H, Kubota Y, Horiike A, Izumizaki M, Wada S, Yoshimura K, Hoffman RM, Tsunoda T. PMID: 39730175.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Ivermectin Combined With Recombinant Methioninase (rMETase) Synergistically Eradicates MiaPaCa-2 Pancreatic Cancer Cells. Anticancer Res. 2025 Jan; 45(1):97-103. Morinaga S, Han Q, Mizuta K, Kang BM, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39740811.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Comparison of Cell-death Kinetics of Recombinant Methioninase (rMETase)-treated Cancer and Normal Cells: Only Cancer Cells Undergo Methionine-depletion Catastrophe at Low rMETase Concentrations. Anticancer Res. 2025 Jan; 45(1):105-111. Kang BM, Han Q, Mizuta K, Morinaga S, Bouvet M, Hoffman RM. PMID: 39740830.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Alternating Oxaliplatin and Irinotecan Chemotherapy Combined With Capecitabine and Bevacizumab for Microsatellite-stable Stage IV Metastatic Colon Cancer With a BRAF V600E Mutation: Two Case Reports Indicating Survival Improvement over Standard Therapy. Anticancer Res. 2025 Jan; 45(1):399-404. Zhang Y, Li X, Li S, Yang Z, Hoffman RM, Yu C. PMID: 39740847.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. The Combination of Tumor-targeting Salmonella typhimurium A1-R Plus the Autophagy-inhibitor Chloroquine Synergistically Eradicates HT1080 Fibrosarcoma Cells In Vitro and In Vivo. In Vivo. 2025 Jan-Feb; 39(1):102-109. Morinaga S, Zhao M, Mizuta K, Kang BM, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39740880.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. Synergistic Eradication of Fibrosarcoma With Acquired Ifosfamide Resistance Using Methionine Restriction Combined With Ifosfamide in Nude-mouse Models. In Vivo. 2025 Jan-Feb; 39(1):120-126. Morinaga S, Han Q, Mizuta K, Kang BM, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39740911.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. Sub-toxic cisplatin concentrations induce extensive chromosomal, nuclear and nucleolar abnormalities associated with high malignancy before acquired resistance develops: Implications for clinical caution. PLoS One. 2024; 19(12):e0311976. Delinassios JG, Hoffman RM, Koumakis G, Palitskaris D, Poulatsidou KN, Delinasios GJ. PMID: 39724069.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. The Potential of Hair-Follicle-Associated Pluripotent (HAP) Stem Cells for Regenerative Medicine. Methods Mol Biol. 2024 Dec 21. Obara K, Baba K, Hamada Y, Hoffman RM. PMID: 39702862.
      View in: PubMed   Mentions:    Fields:    
    12. Selective Synergy of Recombinant Methioninase Plus Docetaxel Against Docetaxel-resistant and -sensitive Fibrosarcoma Cells Compared to Normal Fibroblasts. Anticancer Res. 2024 Dec; 44(12):5207-5213. Morinaga S, Han Q, Mizuta K, Kang BM, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39626920.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. Recombinant Methioninase Synergistically Reverses High-docetaxel Resistance Developed in Osteosarcoma Cells. Anticancer Res. 2024 Nov; 44(11):4773-4778. Morinaga S, Han Q, Mizuta K, Kang BM, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39477291.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. Accurate and Safe Tumor Targeting of Orally-administered Salmonella typhimurium A1-R Leads to Regression of an Aggressive Fibrosarcoma in Nude Mice. In Vivo. 2024 Nov-Dec; 38(6):2601-2609. Morinaga S, Zhao M, Mizuta K, Kang BM, Sato M, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39477429; PMCID: PMC11535920.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    15. Serum Exosomes Expressing CD9, CD63 and HER2 From Breast-Cancer Patients Decreased After Surgery of the Primary Tumor: A Potential Biomarker of Tumor Burden. Cancer Genomics Proteomics. 2024 Nov-Dec; 21(6):580-584. Inubushi S, Kunihisa T, Kuniyasu M, Inoue S, Yamamoto M, Yamashita Y, Miki M, Mizumoto S, Baba M, Hoffman RM, Tanino H. PMID: 39467625; PMCID: PMC11534029.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    16. Extensive DNA Damage and Loss of Cell Viability Occur Synergistically With the Combination of Recombinant Methioninase and Paclitaxel on Pancreatic Cancer Cells which Report DNA-Damage Response in Real Time. Cancer Genomics Proteomics. 2024 Nov-Dec; 21(6):585-590. Morinaga S, Han Q, Mizuta K, Kang BM, Sato M, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39467627; PMCID: PMC11534037.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    17. Targeting Human Pancreatic Cancer with a Fluorophore-Conjugated Mucin 4 (MUC4) Antibody: Initial Characterization in Orthotopic Cell Line Mouse Models. J Clin Med. 2024 Oct 18; 13(20). Jaiswal S, Cox KE, Amirfakhri S, Din Parast Saleh A, Kobayashi K, Lwin TM, Talib S, Aithal A, Mallya K, Jain M, Mohs AM, Hoffman RM, Batra SK, Bouvet M. PMID: 39458160; PMCID: PMC11508345.
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    18. Lymphovascular Tumoral Emboli in Inflammatory Breast Cancer Result from Haptotaxis-Mediated Encircling Lymphangiogenesis. Lymphatics. 2024 Dec; 2(4):195-211. Wang J, Hoffman RM, Ye Y, Dillard J, Barsky SH. PMID: 39669476; PMCID: PMC11632961.
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    19. Loss of Malignancy of Super-Methotrexate-resistant Osteosarcoma Cells Is Associated With an Increase of Methylated Histone Marks H3K9me3 and H3K27me3. Anticancer Res. 2024 Oct; 44(10):4213-4218. Aoki Y, Kubota Y, Masaki N, Obara K, Tome Y, Bouvet M, Nishida K, Hoffman RM. PMID: 39348992.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    20. Accurate Co-Localization of Luciferase Expression and Fluorescent Anti-CEA Antibody Targeting of Liver Metastases in an Orthotopic Mouse Model of Colon Cancer. Cancers (Basel). 2024 Sep 29; 16(19). Lee KH, Cox KE, Amirfakhri S, Jaiswal S, Liu S, Hosseini M, Lwin TM, Yazaki PJ, Hoffman RM, Bouvet M. PMID: 39409961; PMCID: PMC11475688.
      View in: PubMed   Mentions:
    21. Non-Invasive Direct Visualization of Luciferase-Luciferin Emitted Light Producing True Images from an Orthotopic Lung Cancer Xenograft Model in Nude Mice Using an Ultra-sensitive Low-light Camera and Optics. In Vivo. 2024 Sep-Oct; 38(5):2122-2125. Mizuta K, Gallagher S, Wang A, Chang N, Morinaga S, Sato M, Kang BM, Hoffman RM. PMID: 39187316; PMCID: PMC11363753.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    22. EL4 Murine-Lymphoma-Stromal-Cell Fusion Hybrids Observed With Multiple Distinct Morphologies in the Primary Tumor and Metastatic Organs of a Syngeneic Mouse Model. In Vivo. 2024 Sep-Oct; 38(5):2115-2121. Yamashita K, Suetsugu A, Hayashi S, Shimizu M, Hoffman RM. PMID: 39187323; PMCID: PMC11363744.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    23. First-line Chemotherapy in Combination With Oral Recombinant Methioninase and a Low-methionine Diet for a Stage IV Inoperable Pancreatic-Cancer Patient Resulted in 40% Tumor Reduction and an 86% CA19-9 Biomarker Decrease. Anticancer Res. 2024 Sep; 44(9):3885-3889. Sato M, Han Q, Hozumi C, Kujiraoka H, Mizuta K, Morinaga S, Kang BM, Kobayashi N, Ichikawa Y, Nakajima A, Hoffman RM. PMID: 39197890.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    24. [11C]Methionine PET vs. [18F]Fluorodeoxyglucose PET Whole-body Imaging to Determine the Extent of Methionine-addiction Compared to Glucose-addiction of Primary and Metastatic Cancer of the Trunk in Patients. Anticancer Res. 2024 Sep; 44(9):3891-3898. Sato M, Sato T, Hozumi C, Han Q, Mizuta K, Morinaga S, Kang BM, Kobayashi N, Ichikawa Y, Nakajima A, Hoffman RM. PMID: 39197923.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Overcoming High Trabectedin Resistance of Soft-tissue Sarcoma With Recombinant Methioninase: A Potential Solution of a Recalcitrant Clinical Problem. Anticancer Res. 2024 Sep; 44(9):3785-3791. Morinaga S, Han Q, Mizuta K, Kang BM, Sato M, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39197928.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    26. Recombinant Methioninase Increases Eribulin Efficacy 16-fold in Highly Eribulin-resistant HT1080 Fibrosarcoma Cells, Demonstrating Potential to Overcome the Clinical Challenge of Drug-resistant Soft-tissue Sarcoma. Anticancer Res. 2024 Sep; 44(9):3777-3783. Morinaga S, Han Q, Mizuta K, Kang BM, Sato M, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39197933.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    27. Imaging Transgenic Nude Mice Expressing Spectrally-distinct Fluorescent Reporters Emitting From Blue to Far Red Light With One Instrument With Single-nanometer-tuning of Laser-excitation Fluorescence. Cancer Diagn Progn. 2024 Sep-Oct; 4(5):563-566. Mizuta K, Reynoso J, Gallagher S, Wang A, Chang N, Morinaga S, Sato M, Kang BM, Hoffman RM. PMID: 39238628; PMCID: PMC11372684.
      View in: PubMed   Mentions:
    28. The Role of Microsurgery and Fluorescent-reporter Genes in Establishing Mouse Models for Real-Time Imaging of Metastatic Cancer-Cell Trafficking and Colony Formation: A Revolutionary and Disruptive Technology for Metastasis Research. Cancer Diagn Progn. 2024 Sep-Oct; 4(5):544-557. Morinaga S, Yamamoto N, Yamauchi K, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39238629; PMCID: PMC11372698.
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    29. Recombinant Methioninase Is Selectively Synergistic With Doxorubicin Against Wild-type Fibrosarcoma Cells Compared to Normal Cells and Overcomes Highly-Doxorubicin-resistant Fibrosarcoma. Anticancer Res. 2024 Aug; 44(8):3261-3268. Morinaga S, Han Q, Mizuta K, Kang BM, Sato M, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39060039.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    30. Exosome Transfer Between Different Co-implanted Human Pancreatic Cancer Cell Lines Occurs in the Primary Tumor and Multiple Metastatic Sites of Nude Mice But Not in Co-Culture In Vitro. Anticancer Res. 2024 Aug; 44(8):3307-3315. Yamashita K, Suetsugu A, Hayashi S, Shimizu M, Hoffman RM. PMID: 39060068.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    31. Maximum Efficacy of Immune Checkpoint Inhibitors Occurs in Esophageal Cancer Patients With a Low Neutrophil-to-Lymphocyte Ratio and Good Performance Status Prior to Treatment. Anticancer Res. 2024 Aug; 44(8):3397-3407. Hirasawa Y, Kubota Y, Mura E, Suzuki R, Tsurui T, Iriguchi N, Ishiguro T, Ohkuma R, Shimokawa M, Ariizumi H, Horiike A, Wada S, Ariyoshi T, Goto S, Otsuka K, Murakami M, Kiuchi Y, Yoshimura K, Hoffman RM, Tsunoda T. PMID: 39060084.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    32. The Combination of Methionine Restriction and Docetaxel Synergistically Arrests Androgen-independent Prostate Cancer But Not Normal Cells. Cancer Diagn Progn. 2024 Jul-Aug; 4(4):402-407. Mizuta K, Mori R, Han Q, Morinaga S, Sato M, Kang BM, Bouvet M, Tome Y, Nishida K, Hoffman RM. PMID: 38962551; PMCID: PMC11215443.
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    33. Synergy of Rapamycin and Methioninase on Colorectal Cancer Cells Requires Simultaneous and Not Sequential Administration: Implications for mTOR Inhibition. Cancer Diagn Progn. 2024 Jul-Aug; 4(4):396-401. Ardjmand D, Sato M, Han Q, Kubota Y, Mizuta K, Morinaga S, Hoffman RM. PMID: 38962555; PMCID: PMC11215436.
      View in: PubMed   Mentions:
    34. Expression of PD-L1 Is Increased by Methionine Restriction Using Recombinant Methioninase in Human Colorectal Cancer Cells. Cancer Genomics Proteomics. 2024 Jul-Aug; 21(4):395-398. Mizuta K, Kang BM, Han Q, Kubota Y, Morinaga S, Sato M, Bouvet M, Tome Y, Nishida K, Hoffman RM. PMID: 38944421; PMCID: PMC11215431.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    35. Induction of the DNA-Repair Gene POLQ only in BRCA1-mutant Breast-Cancer Cells by Methionine Restriction. Cancer Genomics Proteomics. 2024 Jul-Aug; 21(4):399-404. Kunihisa T, Inubushi S, Tanino H, Hoffman RM. PMID: 38944428; PMCID: PMC11215430.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    36. Head-to-head Comparison of Green Fluorescent Protein (GFP) Imaging With Luciferase-luciferin Imaging In Vivo Using Single-nanometer Laser-excitation Tuning and an Ultra-low-light-detection Camera and Optics Demonstrates the Superiority of GFP. Anticancer Res. 2024 Jul; 44(7):2823-2826. Mizuta K, Gallagher S, Wang A, Chang N, Morinaga S, Sato M, Kang BM, Hoffman RM. PMID: 38925805.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    37. Reduced Malignancy of Super Methotrexate-resistant Osteosarcoma Cells With Dihydrofolate Reductase Amplification Despite Paradoxical Gain of Oncogenic PI3K/AKT/mTOR and c-MYC expression. Anticancer Res. 2024 Jul; 44(7):2787-2792. Aoki Y, Kubota Y, Masaki N, Obara K, Tome Y, Bouvet M, Nishida K, Hoffman RM. PMID: 38925854.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    38. Targeting Patient-Derived Orthotopic Gastric Cancers with a Fluorescent Humanized Anti-CEA Antibody. Ann Surg Oncol. 2024 Sep; 31(9):6291-6299. Cox KE, Turner MA, Lwin TM, Amirfakhri S, Kelly KJ, Hosseini M, Ghosh P, Obonyo M, Hoffman RM, Yazaki PJ, Bouvet M. PMID: 38888861; PMCID: PMC11300635.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    39. Hair-follicle associated pluripotent (HAP)-cell-sheet implantation enhanced wound healing in diabetic db/db mice. PLoS One. 2024; 19(6):e0304676. Hasegawa-Haruki A, Obara K, Takaoka N, Shirai K, Hamada Y, Arakawa N, Aki R, Hoffman RM, Amoh Y. PMID: 38875234; PMCID: PMC11178214.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    40. DNA-Binding Agent Trabectedin Combined With Recombinant Methioninase Is Synergistic to Decrease Fibrosarcoma Cell Viability and Induce Nuclear Fragmentation But Not Synergistic on Normal Fibroblasts. Anticancer Res. 2024 Jun; 44(6):2359-2367. Morinaga S, Han Q, Kubota Y, Mizuta K, Kang BM, Sato M, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 38821601.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    41. The potential of methioninase for cancer treatment. Biochim Biophys Acta Rev Cancer. 2024 07; 1879(4):189122. Abo Qoura L, Balakin KV, Hoffman RM, Pokrovsky VS. PMID: 38796027.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    42. Efficacy of Recombinant Methioninase on Late-stage Patient Cancer in the Histoculture Drug Response Assay (HDRA) as a Potential Functional Biomarker of Sensitivity to Methionine-restriction Therapy in the Clinic. Cancer Diagn Progn. 2024 May-Jun; 4(3):239-243. Kubota Y, Sasaki M, Han Q, Hozumi C, Tsunoda T, Hoffman RM. PMID: 38707720; PMCID: PMC11062157.
      View in: PubMed   Mentions:
    43. Extensive Shrinkage and Long-term Stable Disease in a Teenage Female Patient With High-grade Glioma Treated With Temozolomide and Radiation in Combination With Oral Recombinant Methioninase and a Low-methionine Diet. In Vivo. 2024 May-Jun; 38(3):1459-1464. Sato M, Han Q, Mizuta K, Mori R, Kang BM, Morinaga S, Kobayashi N, Ichikawa Y, Nakajima A, Hoffman RM. PMID: 38688589; PMCID: PMC11059867.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    44. Targeting Methionine Addiction Combined With Low-dose Irinotecan Arrested Colon Cancer in Contrast to High-dose Irinotecan Alone, Which Was Ineffective, in a Nude-mouse Model. In Vivo. 2024 May-Jun; 38(3):1058-1063. Sato M, Mizuta K, Han Q, Morinaga S, Kang BM, Kubota Y, Mori R, Baranov A, Kobayashi K, Ardjmand D, Kobayashi N, Bouvet M, Ichikawa Y, Nakajima A, Hoffman RM. PMID: 38688611; PMCID: PMC11059914.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    45. Methionine Dependence of Hair Maintenance in C57BL/6 Mice. In Vivo. 2024 May-Jun; 38(3):1199-1202. Kubota Y, Varshney N, Kobayashi K, Tsunoda T, Hoffman RM. PMID: 38688645; PMCID: PMC11059892.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    46. Reduction of Tumor Biomarkers from very High to Normal and Extensive Metastatic Lesions to Undetectability in a Patient With Stage IV HER2-positive Breast Cancer Treated With Low-dose Trastuzumab Deruxtecan in Combination With Oral Recombinant Methioninase and a Low-methionine Diet. Anticancer Res. 2024 Apr; 44(4):1499-1504. Sato M, Han Q, Mori R, Mizuta K, Kang BM, Morinaga S, Kobayashi N, Ichikawa Y, Nakajima A, Hoffman RM. PMID: 38538002.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    47. Anlotinib Inhibits Ovarian Cancer and Enhances Cisplatinum Sensitivity via Suppressing NOTCH2 Expression and Stemness. Anticancer Res. 2024 Apr; 44(4):1399-1407. Xu X, Wang Q, Shen L, Shen Y, Liu H, Liu Y, Yang Z, Hoffman RM, Feng W. PMID: 38538004.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    48. Selective Synergy of Rapamycin Combined With Methioninase on Cancer Cells Compared to Normal Cells. Anticancer Res. 2024 Mar; 44(3):929-933. Ardjmand D, Kubota Y, Sato M, Han Q, Mizuta K, Morinaga S, Hoffman RM. PMID: 38423628.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    49. Extensive Synergy Between Recombinant Methioninase and Eribulin Against Fibrosarcoma Cells But Not Normal Fibroblasts. Anticancer Res. 2024 Mar; 44(3):921-928. Morinaga S, Han Q, Kubota Y, Mizuta K, Kang BM, Sato M, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Hoffman RM. PMID: 38423656.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    50. The Expression of the Claudin Family of Proteins in Colorectal Cancer. Biomolecules. 2024 Feb 24; 14(3). Cox KE, Liu S, Hoffman RM, Batra SK, Dhawan P, Bouvet M. PMID: 38540693; PMCID: PMC10967842.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    51. Rat hair-follicle-associated pluripotent (HAP) stem cells can differentiate into atrial or ventricular cardiomyocytes in culture controlled by specific supplementation. PLoS One. 2024; 19(1):e0297443. Takaoka N, Yamane M, Hasegawa A, Obara K, Shirai K, Aki R, Hatakeyama H, Hamada Y, Arakawa N, Tanaka M, Hoffman RM, Amoh Y. PMID: 38277391; PMCID: PMC10817212.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    52. Precise Non-invasive Imaging Mouse Model of Pancreatic Cancer: Very Narrow Band-width Laser Fluorescence Excitation of Green Fluorescent Protein Provides Ultra-bright Tumor Images With no Skin Autofluorescence. Cancer Diagn Progn. 2024 Jan-Feb; 4(1):30-33. Kubota Y, Wang A, Chang N, Tarantino S, Gallagher S, Aoki Y, Masaki N, Obara K, Morinaga S, Tsunoda T, Hoffman RM. PMID: 38173656; PMCID: PMC10758840.
      View in: PubMed   Mentions: 2  
    53. Non-invasive Fluorescence Imaging of Breast Cancer Metastasis to the Brain in an Orthotopic Nude-mouse Model With Very-narrow-band-width Laser Excitation of Red Fluorescent Protein Resulting in an Ultra-bright Signal Without Skin Autofluorescence. In Vivo. 2024 Jan-Feb; 38(1):69-72. Kubota Y, Aoki Y, Wang A, Chang N, Tarantino S, Gallagher S, Tsunoda T, Hoffman RM. PMID: 38148053; PMCID: PMC10756473.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    54. [11C] Methionine-PET Imaging as a Cancer Biomarker for Methionine Addiction and Sensitivity to Methionine-restriction-based Combination Chemotherapy. In Vivo. 2024 Jan-Feb; 38(1):253-258. Kubota Y, Sato T, Han Q, Hozumi C, Morinaga S, Mizuta K, Tsunoda T, Hoffman RM. PMID: 38148095; PMCID: PMC10756438.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    55. Non-classical Monocytes Enhance the Efficacy of Immune Checkpoint Inhibitors on Colon Cancer in a Syngeneic Mouse Model. Anticancer Res. 2024 Jan; 44(1):23-29. Goshima T, Ieguchi K, Onishi N, Shimizu T, Takayanagi D, Watanabe M, Fujimoto Y, Ohkuma R, Suzuki R, Tsurui T, Mura E, Iriguchi N, Ishiguro T, Shimokawa M, Hirasawa Y, Kubota Y, Ariizumi H, Horiike A, Yoshimura K, Tsuji M, Kiuchi Y, Kobayashi S, Fujishiro J, Hoffman RM, Tsunoda T, Wada S. PMID: 38159965.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    56. Recombinant Methioninase Decreased the Effective Dose of Irinotecan by 15-fold Against Colon Cancer Cells: A Strategy for Effective Low-toxicity Treatment of Colon Cancer. Anticancer Res. 2024 Jan; 44(1):31-35. Sato M, Han Q, Kubota Y, Baranov A, Ardjmand D, Mizuta K, Morinaga S, Kang BM, Kobayashi N, Bouvet M, Ichikawa Y, Nakajima A, Hoffman RM. PMID: 38159986.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    57. Methionine restriction of glioma does not induce MGMT and greatly improves temozolomide efficacy in an orthotopic nude-mouse model: A potential curable approach to a clinically-incurable disease. Biochem Biophys Res Commun. 2024 02 05; 695:149418. Kubota Y, Aoki Y, Masaki N, Obara K, Hamada K, Han Q, Bouvet M, Tsunoda T, Hoffman RM. PMID: 38176171.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    58. Asymmetric and symmetric protein arginine methylation in methionine-addicted human cancer cells. PLoS One. 2023; 18(12):e0296291. Holtz AG, Lowe TL, Aoki Y, Kubota Y, Hoffman RM, Clarke SG. PMID: 38134182; PMCID: PMC10745221.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    59. The Combination of Methioninase and Ethionine Exploits Methionine Addiction to Selectively Eradicate Osteosarcoma Cells and Not Normal Cells and Synergistically Down-regulates the Expression of C-MYC. Cancer Genomics Proteomics. 2023 Dec; 20(6suppl):679-685. Aoki Y, Kubota Y, Han Q, Masaki N, Obara K, Bouvet M, Chawla SP, Tome Y, Nishida K, Hoffman RM. PMID: 38035708; PMCID: PMC10687729.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    60. Recombinant Methioninase Lowers the Effective Dose of Regorafenib Against Colon-Cancer Cells: A Strategy for Widespread Clinical Use of a Toxic Drug. Cancer Diagn Progn. 2023 Nov-Dec; 3(6):655-659. Choobin BB, Kubota Y, Han Q, Ardjmand D, Morinaga S, Mizuta K, Bouvet M, Tsunoda T, Hoffman RM. PMID: 37927805; PMCID: PMC10619565.
      View in: PubMed   Mentions: 2  
    61. Recombinant-methioninase-producing Escherichia coli Instilled in the Microbiome Inhibits Triple-negative Breast Cancer in an Orthotopic Cell-line Mouse Model. Cancer Diagn Progn. 2023 Nov-Dec; 3(6):649-654. Kubota Y, Han Q, Morinaga S, Mizuta K, Bouvet M, Tsunoda T, Hoffman RM. PMID: 37927811; PMCID: PMC10619576.
      View in: PubMed   Mentions:
    62. Non-invasive omics analysis delineates molecular changes in water-only fasting and its sex-discriminating features in metabolic syndrome patients. MedComm (2020). 2023 Dec; 4(6):e393. Jiang Y, Tang Z, Zhu X, Xiao B, Tian H, Lei X, Peng H, Qin J, Zhang Y, Hoffman RM, Hu X, Chen Q, Ji G, Jia L. PMID: 37929015; PMCID: PMC10622739.
      View in: PubMed   Mentions: 2  
    63. Erratum: ATR inhibition sensitizes liposarcoma to doxorubicin by increasing DNA damage. Am J Cancer Res. 2023; 13(10):5021-5023. Cui J, Dean D, Hornicek FJ, Pollock RE, Hoffman RM, Duan Z. PMID: 37970365; PMCID: PMC10636686.
      View in: PubMed   Mentions:
    64. Humanized Anti-Carcinoembryonic Antigen Antibodies Brightly Target and Label Gastric Cancer in Orthotopic Mouse Models. J Surg Res. 2024 01; 293:701-708. Cox KE, Turner MA, Amirfakhri S, Lwin TM, Hosseini M, Ghosh P, Obonyo M, Murakami T, Hoffman RM, Yazaki PJ, Bouvet M. PMID: 37839102; PMCID: PMC11060874.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    65. High Clinical Concordance of Drug Resistance in Patient-derived Orthotopic Xenograft (PDOX) Mouse Models: First Step to Validated Precise Individualized Cancer Chemotherapy. Anticancer Res. 2023 Oct; 43(10):4277-4284. Higuchi T, Yamamoto N, Hayashi K, Miwa S, Igarashi K, Tsuchiya H, Hoffman RM. PMID: 37772554.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    66. Methionine Restriction Increases Exosome Production and Secretion in Breast Cancer Cells. Cancer Genomics Proteomics. 2023 Sep-Oct; 20(5):412-416. Inubushi S, Kunihisa T, Mizumoto S, Inoue S, Miki M, Suetsugu A, Tanino H, Hoffman RM. PMID: 37643781; PMCID: PMC10464940.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    67. Rapid Reduction of CEA and Stable Metastasis in an NRAS-mutant Rectal-Cancer Patient Treated With FOLFIRI and Bevacizumab Combined With Oral Recombinant Methioninase and a Low-Methionine Diet Upon Metastatic Recurrence After FOLFIRI and Bevacizumab Treatment Alone. In Vivo. 2023 Sep-Oct; 37(5):2134-2138. Kubota Y, Han Q, Morinaga S, Tsunoda T, Hoffman RM. PMID: 37652473; PMCID: PMC10500498.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    68. SLC26A3/NHERF2-IκB/NFκB/p65 feedback loop suppresses tumorigenesis and metastasis in colorectal cancer. Oncogenesis. 2023 Aug 12; 12(1):41. Lin C, Lin P, Lin H, Yao H, Liu S, He R, Chen H, Teng Z, Hoffman RM, Ye J, Zhu G. PMID: 37573425; PMCID: PMC10423209.
      View in: PubMed   Mentions: 1  
    69. PEGylated Fluorescent Anti-carcinoembryonic Antigen Antibody Labels Colorectal Cancer Tumors in Orthotopic Mouse Models. J Surg Res. 2023 11; 291:596-602. Turner MA, Amirfakhri S, Nishino H, Neel NC, Hosseini M, Cox KE, Lwin TM, Li L, Hong T, Sherman A, Shively JE, Hoffman RM, Yazaki PJ, Bouvet M. PMID: 37540977.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    70. Long-lasting Limb Salvage After Malignant Femoral-Bone Tumor Resection Reconstructed With a Thin-mantle Titanium Stem Fixated With Cement. Anticancer Res. 2023 Aug; 43(8):3507-3511. Aoki Y, Tome Y, Oshiro H, Mizuta K, Katsuki R, Hoffman RM, Nishida K. PMID: 37500137.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    71. Positive Circumferential Resection Margin in Rectal Cancer Is a Robust Predictor of Poor Long-term Prognosis With Clinicopathological Bias Between Groups Compensated by Propensity-score Matching Analysis. Anticancer Res. 2023 Aug; 43(8):3623-3630. Sugimoto K, Takahashi H, Irie T, Kawaguchi M, Kobari A, Amemiya K, Tsuchiya Y, Motegi S, Tsukamoto R, Honjo K, Okazawa YU, Kawai M, Ishiyama S, Takahashi M, Hoffman RM, Sakamoto K. PMID: 37500146.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    72. Bioinformatics Analysis of Immune Infiltration In Endometrial Carcinoma Tumors and its Relationship With Prognosis. Cancer Diagn Progn. 2023 Jul-Aug; 3(4):416-427. Lin Y, Liu S, Bian L, Lin C, Lin P, Teng Z, Hoffman RM, Zhu G, Zhang B. PMID: 37405226; PMCID: PMC10316055.
      View in: PubMed   Mentions:
    73. Targeting Autophagy With the Synergistic Combination of Chloroquine and Rapamycin as a Novel Effective Treatment for Well-differentiated Liposarcoma. Cancer Genomics Proteomics. 2023 Jul-Aug; 20(4):317-322. Masaki N, Aoki Y, Obara K, Kubota Y, Bouvet M, Miyazaki J, Hoffman RM. PMID: 37400145; PMCID: PMC10320558.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    74. Meckel's Diverticulum Carcinoma Is Arrested by Oxaliplatinum and Eradicated by 5-Fluorouracil in a PDX Mouse Model Indicating Candidate First-line Treatment for a Rare Cancer. In Vivo. 2023 Jul-Aug; 37(4):1482-1485. Masaki N, Yonemura Y, Hozumi C, Obara K, Kubota Y, Aoki Y, Hoffman RM. PMID: 37369464; PMCID: PMC10347928.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    75. Precise and Facile Endotracheal Lung-tumor-implantation Mouse Model Visualized by GFP Expression. In Vivo. 2023 Jul-Aug; 37(4):1477-1481. Aoki Y, Kobayashi KJ, Varshney N, Kubota Y, Masaki N, Obara K, Wang JD, Tome Y, Bouvet M, Nishida K, Hoffman RM. PMID: 37369517; PMCID: PMC10347943.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    76. Targeting Methionine Addiction of Cancer Cells with Methioninase. Biochemistry (Mosc). 2023 Jul; 88(7):944-952. Pokrovsky VS, Qoura LA, Demidova EA, Han Q, Hoffman RM. PMID: 37751865.
      View in: PubMed   Mentions: 5     Fields:    
    77. Old-age-induced obesity reversed by a methionine-deficient diet or oral administration of recombinant methioninase-producing Escherichia coli in C57BL/6 mice. Aging (Albany NY). 2023 06 09; 15(11):4642-4648. Kubota Y, Han Q, Reynoso J, Aoki Y, Masaki N, Obara K, Hamada K, Bouvet M, Tsunoda T, Hoffman RM. PMID: 37301544; PMCID: PMC10292902.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    78. Colon-cancer liver metastasis is effectively targeted by recombinant methioninase (rMETase) in an orthotopic mouse model. Tissue Cell. 2023 Aug; 83:102125. Miyake K, Han Q, Murakami T, Kiyuna T, Kawaguchi K, Igarashi K, Lwin TM, Miyake M, Yamamoto J, Bouvet M, Endo I, Hoffman RM. PMID: 37320867.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    79. Highly Selective Targeting of Pancreatic Cancer in the Liver with a Near-Infrared Anti-MUC5AC Probe in a PDOX Mouse Model: A Proof-of-Concept Study. J Pers Med. 2023 May 20; 13(5). Turner MA, Cox KE, Neel N, Amirfakhri S, Nishino H, Clary BM, Hosseini M, Natarajan G, Mallya K, Mohs AM, Hoffman RM, Batra SK, Bouvet M. PMID: 37241027; PMCID: PMC10221372.
      View in: PubMed   Mentions:
    80. Synergy of Combining Methionine Restriction and Chemotherapy: The Disruptive Next Generation of Cancer Treatment. Cancer Diagn Progn. 2023 May-Jun; 3(3):272-281. Kubota Y, Han Q, Aoki Y, Masaki N, Obara K, Hamada K, Hozumi C, Wong ACW, Bouvet M, Tsunoda T, Hoffman RM. PMID: 37168964; PMCID: PMC10165382.
      View in: PubMed   Mentions: 14  
    81. Specific Targeting and Labeling of Colonic Polyps in CPC-APC Mice with Mucin 5AC Fluorescent Antibodies: A Model for Detection of Early Colon Cancer. Curr Issues Mol Biol. 2023 Apr 11; 45(4):3347-3358. Turner MA, Cox KE, Liu S, Neel N, Amirfakhri S, Nishino H, Hosseini M, Alcantara JA, Abd El-Hafeez AA, Lwin TM, Mallya K, Pisegna JR, Singh SK, Ghosh P, Hoffman RM, Batra SK, Bouvet M. PMID: 37185743; PMCID: PMC10136452.
      View in: PubMed   Mentions: 1     Fields:    
    82. Oncogenes and Methionine Addiction of Cancer: Role of c-MYC. Cancer Genomics Proteomics. 2023 Mar-Apr; 20(2):165-170. Aoki Y, Han Q, Kubota Y, Masaki N, Obara K, Tome Y, Bouvet M, Nishida K, Hoffman RM. PMID: 36870694; PMCID: PMC9989672.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    83. The Mucin Family of Proteins: Candidates as Potential Biomarkers for Colon Cancer. Cancers (Basel). 2023 Feb 27; 15(5). Cox KE, Liu S, Lwin TM, Hoffman RM, Batra SK, Bouvet M. PMID: 36900282; PMCID: PMC10000725.
      View in: PubMed   Mentions: 17  
    84. Superiority of [11C]methionine over [18F]deoxyglucose for PET Imaging of Multiple Cancer Types Due to the Methionine Addiction of Cancer. Int J Mol Sci. 2023 Jan 18; 24(3). Kubota Y, Sato T, Hozumi C, Han Q, Aoki Y, Masaki N, Obara K, Tsunoda T, Hoffman RM. PMID: 36768257; PMCID: PMC9915427.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    85. Direct implantation of hair-follicle-associated pluripotent (HAP) stem cells repairs intracerebral hemorrhage and reduces neuroinflammation in mouse model. PLoS One. 2023; 18(1):e0280304. Obara K, Shirai K, Hamada Y, Arakawa N, Hasegawa A, Takaoka N, Aki R, Hoffman RM, Amoh Y. PMID: 36638123; PMCID: PMC9838830.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    86. TRAF6 regulates the abundance of RIPK1 and inhibits the RIPK1/RIPK3/MLKL necroptosis signaling pathway and affects the progression of colorectal cancer. Cell Death Dis. 2023 01 05; 14(1):6. Lin P, Lin C, He R, Chen H, Teng Z, Yao H, Liu S, Hoffman RM, Ye J, Zhu G. PMID: 36604411; PMCID: PMC9816173.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    87. Recombinant Oral Methioninase (o-rMETase) Combined With Oxaliplatinum Plus 5-Fluorouracil Improves Survival of Mice With Massive Colon-Cancer Peritoneal Carcinomatosis. Anticancer Res. 2023 Jan; 43(1):19-24. Kim MJ, Han Q, Bouvet M, Hoffman RM, Park JH. PMID: 36585181.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    88. Elevated Pro-inflammatory Cytokine Levels in Acute Reflux Esophagitis Are Reduced by 1,25 Dihydroxy Vitamin D3. In Vivo. 2023 Jan-Feb; 37(1):79-87. Wei J, Zhang J, Jiang Y, Lian T, Zhang P, Hoffman RM, Zhu G, Zhuang Z. PMID: 36593017; PMCID: PMC9843781.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    89. Synergy of oral recombinant methioninase (rMETase) and 5-fluorouracil on poorly differentiated gastric cancer. Biochem Biophys Res Commun. 2023 Feb 05; 643:48-54. Miyake M, Miyake K, Han Q, Igarashi K, Kawaguchi K, Barangi M, Kiyuna T, Sugisawa N, Higuchi T, Oshiro H, Zhang Z, Razmjooei S, Bouvet M, Endo I, Hoffman RM. PMID: 36586158.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    90. Hair follicle associated pluripotent (HAP) stem cells jump from transplanted whiskers to pelage follicles and stimulate hair growth. Sci Rep. 2022 12 07; 12(1):21174. Obara K, Reynoso J, Hamada Y, Aoki Y, Kubota Y, Masaki N, Amoh Y, Hoffman RM. PMID: 36476963; PMCID: PMC9729176.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    91. Elimination of Axillary-Lymph-Node Metastases in a Patient With Invasive Lobular Breast Cancer Treated by First-line Neo-adjuvant Chemotherapy Combined With Methionine Restriction. Anticancer Res. 2022 Dec; 42(12):5819-5823. Kubota Y, Han Q, Masaki N, Hozumi C, Hamada K, Aoki Y, Obara K, Tsunoda T, Hoffman RM. PMID: 36456116.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    92. Reversion of methionine addiction of osteosarcoma cells to methionine independence results in loss of malignancy, modulation of the epithelial-mesenchymal phenotype and alteration of histone-H3 lysine-methylation. Front Oncol. 2022; 12:1009548. Aoki Y, Han Q, Tome Y, Yamamoto J, Kubota Y, Masaki N, Obara K, Hamada K, Wang JD, Inubushi S, Bouvet M, Clarke SG, Nishida K, Hoffman RM. PMID: 36408173; PMCID: PMC9671209.
      View in: PubMed   Mentions: 17  
    93. Oral Installation of Recombinant Methioninase-producing Escherichia coli into the Microbiome Inhibits Colon-cancer Growth in a Syngeneic Mouse Model. Cancer Genomics Proteomics. 2022 Nov-Dec; 19(6):683-691. Kubota Y, Han Q, Hamada K, Aoki Y, Masaki N, Obara K, Baranov A, Bouvet M, Tsunoda T, Hoffman RM. PMID: 36316039; PMCID: PMC9620449.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    94. Oral-recombinant Methioninase in Combination With Rapamycin Eradicates Osteosarcoma of the Breast in a Patient-derived Orthotopic Xenograft Mouse Model. Anticancer Res. 2022 Nov; 42(11):5217-5222. Masaki N, Han Q, Samonte C, Wu NF, Hozumi C, Wu J, Obara K, Kubota Y, Aoki Y, Bouvet M, Hoffman RM. PMID: 36288875.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    95. Oral-recombinant Methioninase Lowers the Effective Dose and Eliminates Toxicity of Cisplatinum for Primary Osteosarcoma of the Mammary Gland in a Patient-derived Orthotopic Xenograft Mouse Model. In Vivo. 2022 Nov-Dec; 36(6):2598-2603. Masaki N, Han Q, Wu NF, Samonte C, Wu J, Hozumi C, Obara K, Kubota Y, Aoki Y, Miyazaki J, Hoffman RM. PMID: 36309364; PMCID: PMC9677772.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    96. Chloroquine Combined With Rapamycin Arrests Tumor Growth in a Patient-derived Orthotopic Xenograft (PDOX) Mouse Model of Dedifferentiated Liposarcoma. In Vivo. 2022 Nov-Dec; 36(6):2630-2637. Masaki N, Aoki Y, Kubota Y, Obara K, Miyazaki J, Hoffman RM. PMID: 36309387; PMCID: PMC9677795.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    97. Evodiamine inhibits ESCC by inducing M-phase cell-cycle arrest via CUL4A/p53/p21 axis and activating noxa-dependent intrinsic and DR4-dependent extrinsic apoptosis. Phytomedicine. 2023 Jan; 108:154493. Zhang L, Li L, Chen X, Yuan S, Xu T, Zhao W, Li M, Wang F, Hoffman RM, Jia L. PMID: 36265256.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    98. Long-chain Non-coding RNA MIR4435-2HG Expression Correlates With Size of Intestinal Polyps in Children and With Metastasis of Colon Cancer. Anticancer Res. 2022 Oct; 42(10):4707-4714. Zhu D, Guo P, Jin XY, Zhang R, Ji G, Yang Z, Hoffman RM, Sheng W. PMID: 36191994.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    99. Micro RNA miR-1303 Promotion of Proliferation, Migration and Invasion of Human Liver Cancer Cells Is Enhanced by Low Talin 1 (TLN1) Expression. Anticancer Res. 2022 Oct; 42(10):4715-4725. Huang J, Xi Q, Xiong J, Peng H, Yang H, Sun YU, Hoffman RM. PMID: 36192016.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    100. Inhibition of pancreatic cancer-cell growth and metastasis in vivo by a pyrazole compound characterized as a cell-migration inhibitor by an in vitro chemotaxis assay. Biomed Pharmacother. 2022 Nov; 155:113733. Okamoto S, Miyano K, Choshi T, Sugisawa N, Nishiyama T, Kotouge R, Yamamura M, Sakaguchi M, Kinoshita R, Tomonobu N, Katase N, Sasaki K, Nishina S, Hino K, Kurose K, Oka M, Kubota H, Ueno T, Hirai T, Fujiwara H, Kawai C, Itadani M, Morihara A, Matsushima K, Kanegasaki S, Hoffman RM, Yamauchi A, Kuribayashi F. PMID: 36271542.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    101. Resistance to tyrosine kinase inhibitors promotes renal cancer progression through MCPIP1 tumor-suppressor downregulation and c-Met activation. Cell Death Dis. 2022 09 22; 13(9):814. Marona P, Górka J, Kwapisz O, Jura J, Rys J, Hoffman RM, Miekus K. PMID: 36138026; PMCID: PMC9500022.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    102. Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells. Signal Transduct Target Ther. 2022 09 09; 7(1):313. Ni S, Liu Q, Chen X, Ding L, Cai L, Mao F, Shi D, Hoffman RM, Li J, Jia L. PMID: 36075909; PMCID: PMC9458665.
      View in: PubMed   Mentions: 6     Fields:    
    103. Proof of Principle of Combining Fluorescence-Guided Surgery with Photoimmunotherapy to Improve the Outcome of Pancreatic Cancer Therapy in an Orthotopic Mouse Model. Ann Surg Oncol. 2023 Jan; 30(1):618-625. Nishino H, Turner MA, Amirfakhri S, Lwin TM, Hosseini M, Singer BB, Hoffman RM, Bouvet M. PMID: 36057899; PMCID: PMC9726788.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    104. Review: Precise sarcoma patient-derived orthotopic xenograft (PDOX) mouse models enable identification of novel effective combination therapies with the cyclin-dependent kinase inhibitor palbociclib: A strategy for clinical application. Front Oncol. 2022; 12:957844. Higuchi T, Igarashi K, Yamamoto N, Hayashi K, Kimura H, Miwa S, Bouvet M, Tsuchiya H, Hoffman RM. PMID: 36003796; PMCID: PMC9393494.
      View in: PubMed   Mentions: 4  
    105. Long-term Stable Disease in a Rectal-cancer Patient Treated by Methionine Restriction With Oral Recombinant Methioninase and a Low-methionine Diet. Anticancer Res. 2022 Aug; 42(8):3857-3861. Kubota Y, Han Q, Hamada K, Aoki Y, Masaki N, Obara K, Tsunoda T, Hoffman RM. PMID: 35896248.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    106. Proof of concept of improved fluorescence-guided surgery of colon cancer liver metastasis using color-coded imaging of a tumor-labeling fluorescent antibody and indocyanine green restricted to the adjacent liver segment. Surgery. 2022 10; 172(4):1156-1163. Nishino H, Turner MA, Amirfakhri S, Hollandsworth HM, Lwin TM, Hosseini M, Framery B, Cailler F, Pèlegrin A, Hoffman RM, Bouvet M. PMID: 35927078.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    107. Obesity Strongly Promotes Growth of Mouse MC38 Colon Cancer in an Orthotopic-syngeneic C57BL/6 Mouse Model. In Vivo. 2022 Jul-Aug; 36(4):1643-1646. Hamada K, Kubota Y, Aoki Y, Sugisawa N, Yamamoto J, Tashiro Y, Bouvet M, Tsunoda T, Hoffman RM. PMID: 35738603; PMCID: PMC9301442.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    108. The First Mouse Model of Meckel's Diverticulum Carcinoma. In Vivo. 2022 Jul-Aug; 36(4):1603-1607. Masaki N, Yonemura Y, Wu NF, Samonte C, Hozumi C, Kubota Y, Aoki Y, Bouvet M, Miyazaki J, Hoffman RM. PMID: 35738609; PMCID: PMC9301432.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    109. Non-invasively Imageable Tibia-tumor-fragment Implantation Experimental-bone-metastasis Mouse Model of GFP-expressing Prostate Cancer. In Vivo. 2022 Jul-Aug; 36(4):1647-1650. Aoki Y, Masaki N, Tome Y, Kubota Y, Aoki Y, Bouvet M, Nishida K, Hoffman RM. PMID: 35738622; PMCID: PMC9301422.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    110. Anti-mucin 4 fluorescent antibody brightly targets colon cancer in patient-derived orthotopic xenograft mouse models: A proof-of-concept study for future clinical applications. Am J Surg. 2022 10; 224(4):1081-1085. Turner MA, Hollandsworth HM, Amirfakhri S, Lwin TM, Nishino H, Neel NC, Natarajan G, Kaur S, Mallya K, Hoffman RM, Batra SK, Bouvet M. PMID: 35715267; PMCID: PMC9987031.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    111. Fluorescent Anti-CEA Nanobody for Rapid Tumor-Targeting and Imaging in Mouse Models of Pancreatic Cancer. Biomolecules. 2022 05 16; 12(5). Lwin TM, Turner MA, Nishino H, Amirfakhri S, Hernot S, Hoffman RM, Bouvet M. PMID: 35625638; PMCID: PMC9138244.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    112. Hair-follicle-associated pluripotent (HAP) stem cells differentiate into mature beating cardiomyocyte sheets on flexible substrates in vitro. Med Mol Morphol. 2022 Sep; 55(3):248-257. Takaoka N, Yamane M, Obara K, Shirai K, Aki R, Hamada Y, Arakawa N, Hoffman RM, Amoh Y. PMID: 35536435.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    113. Stage IV Pancreatic Cancer Patient Treated With FOLFIRINOX Combined With Oral Methioninase: A Highly-Rare Case With Long-term Stable Disease. Anticancer Res. 2022 May; 42(5):2567-2572. Kubota Y, Han Q, Hozumi C, Masaki N, Yamamoto J, Aoki Y, Tsunoda T, Hoffman RM. PMID: 35489727.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    114. Guanylate-binding Protein 2 Expression Is Associated With Poor Survival and Malignancy in Clear-cell Renal Cell Carcinoma. Anticancer Res. 2022 May; 42(5):2341-2354. Liu Q, Hoffman RM, Song J, Miao S, Zhang J, Ding D, Wang D. PMID: 35489720.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    115. Deletion of MTAP Highly Sensitizes Osteosarcoma Cells to Methionine Restriction With Recombinant Methioninase. Cancer Genomics Proteomics. 2022 May-Jun; 19(3):299-304. Aoki Y, Tome Y, Han Q, Yamamoto J, Hamada K, Masaki N, Kubota Y, Bouvet M, Nishida K, Hoffman RM. PMID: 35430564; PMCID: PMC9016482.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    116. ATR inhibition sensitizes liposarcoma to doxorubicin by increasing DNA damage. Am J Cancer Res. 2022; 12(4):1577-1592. Cui J, Dean D, Hornicek FJ, Pollock RE, Hoffman RM, Duan Z. PMID: 35530299; PMCID: PMC9077062.
      View in: PubMed   Mentions: 3  
    117. Linkage of methionine addiction, histone lysine hypermethylation, and malignancy. iScience. 2022 Apr 15; 25(4):104162. Yamamoto J, Inubushi S, Han Q, Tashiro Y, Sugisawa N, Hamada K, Aoki Y, Miyake K, Matsuyama R, Bouvet M, Clarke SG, Endo I, Hoffman RM. PMID: 35434545; PMCID: PMC9010622.
      View in: PubMed   Mentions: 17  
    118. TRAF6 regulates the signaling pathway influencing colorectal cancer function through ubiquitination mechanisms. Cancer Sci. 2022 Apr; 113(4):1393-1405. Guangwei Z, Zhibin C, Qin W, Chunlin L, Penghang L, Ruofan H, Hui C, Hoffman RM, Jianxin Y. PMID: 35179811; PMCID: PMC8990288.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    119. Indocyanine Green Labeling of Tumors in the Liver Recurring After Radiofrequency Ablation Enables Complete Resection by Fluorescence-guided Surgery. Anticancer Res. 2022 Mar; 42(3):1345-1350. Tashiro Y, Aoki T, Hirai T, Koizumi T, Kusano T, Matsuda K, Yamada K, Nogaki K, Hakozaki T, Wada Y, Shibata H, Tomioka K, Yamazaki T, Saito K, Fujimori A, Enami Y, Hoffman RM. PMID: 35220226.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    120. CHFR-Promoter-Methylation Status Is Predictive of Response to Irinotecan-based Systemic Chemotherapy in Advanced Colorectal Cancer. Anticancer Res. 2022 Feb; 42(2):697-707. Hagiwara T, Sugimoto K, Momose H, Irie T, Honjo K, Okazawa YU, Kawai M, Kawano S, Munakata S, Takahashi M, Kojima Y, Serizawa N, Nagahara A, Hoffman RM, Brock MV, Sakamoto K. PMID: 35093868.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    121. Oral-recombinant Methioninase Converts an Osteosarcoma from Methotrexate-resistant to -sensitive in a Patient-derived Orthotopic-xenograft (PDOX) Mouse Model. Anticancer Res. 2022 Feb; 42(2):731-737. Aoki Y, Tome Y, Han Q, Yamamoto J, Hamada K, Masaki N, Kubota Y, Bouvet M, Nishida K, Hoffman RM. PMID: 35093871.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    122. High Incidence of Lymph-node Metastasis in a Pancreatic-cancer Patient-derived Orthotopic Xenograft (PDOX) NOG-Mouse Model. Anticancer Res. 2022 Feb; 42(2):739-743. Sugisawa N, Miyake K, Higuchi T, Oshiro H, Park JH, Kawaguchi K, Bouvet M, Unno M, Hoffman RM. PMID: 35093872.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    123. Methionine Restriction: Ready for Prime Time in the Cancer Clinic? Anticancer Res. 2022 Feb; 42(2):641-644. Yamamoto J, Han Q, Simon M, Thomas D, Hoffman RM. PMID: 35093861.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    124. Chronic spinal cord injury functionally repaired by direct implantation of encapsulated hair-follicle-associated pluripotent (HAP) stem cells in a mouse model: Potential for clinical regenerative medicine. PLoS One. 2022; 17(1):e0262755. Obara K, Shirai K, Hamada Y, Arakawa N, Yamane M, Takaoka N, Aki R, Hoffman RM, Amoh Y. PMID: 35085322; PMCID: PMC8794105.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    125. Fluorescence Molecular Targeting of Colon Cancer to Visualize the Invisible. Cells. 2022 01 12; 11(2). Lwin TM, Turner MA, Amirfakhri S, Nishino H, Hoffman RM, Bouvet M. PMID: 35053365; PMCID: PMC8773892.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    126. Andrographolide, a diterpene lactone from the Traditional Chinese Medicine Andrographis paniculate, induces senescence in human lung adenocarcinoma via p53/p21 and Skp2/p27. Phytomedicine. 2022 Apr; 98:153933. Zhang J, Li C, Zhang L, Heng Y, Wang S, Pan Y, Cai L, Zhang Y, Xu T, Chen X, Hoffman RM, Jia L. PMID: 35121394.
      View in: PubMed   Mentions: 4     Fields:    
    127. Determinative Structural Features Identified With Probe-based Confocal Endomicroscopy for the Accurate Diagnosis of Gallbladder Malignancy. Anticancer Res. 2022 Jan; 42(1):67-73. Koizumi T, Aoki T, Yamochi T, Tashiro Y, Yamazaki T, Kusano T, Matsuda K, Wada Y, Shibata H, Saito K, Nogaki K, Hakozaki T, Tomioka K, Hirai T, Fujimori A, Mansour DA, Abbas Gahin AE, Hoffman RM. PMID: 34969710.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    128. Extent and Instability of Trimethylation of Histone H3 Lysine Increases With Degree of Malignancy and Methionine Addiction. Cancer Genomics Proteomics. 2022 Jan-Feb; 19(1):12-18. Yamamoto J, Aoki Y, Inubushi S, Han Q, Hamada K, Tashiro Y, Miyake K, Matsuyama R, Bouvet M, Clarke SG, Endo I, Hoffman RM. PMID: 34949655; PMCID: PMC8717956.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    129. Fluorescent Anti-MUC5AC Brightly Targets Pancreatic Cancer in a Patient-derived Orthotopic Xenograft. In Vivo. 2022 Jan-Feb; 36(1):57-62. Turner MA, Hollandsworth HM, Nishino H, Amirfakhri S, Lwin TM, Lowy AM, Kaur S, Natarajan G, Mallya K, Hoffman RM, Batra SK, Bouvet M. PMID: 34972700; PMCID: PMC8765132.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    130. The cancer-inhibitory effects of proliferating tumor-residing fibroblasts. Biochim Biophys Acta Rev Cancer. 2022 01; 1877(1):188673. Delinassios JG, Hoffman RM. PMID: 34953931.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    131. The Use of Fluorescent Anti-CEA Antibodies to Label, Resect and Treat Cancers: A Review. Biomolecules. 2021 Dec 02; 11(12). Turner MA, Lwin TM, Amirfakhri S, Nishino H, Hoffman RM, Yazaki PJ, Bouvet M. PMID: 34944463; PMCID: PMC8699160.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    132. Osteosarcoma Patient-derived Orthotopic Xenograft (PDOX) Models Used to Identify Novel and Effective Therapeutics: A Review. Anticancer Res. 2021 Dec; 41(12):5865-5871. Higuchi T, Igarashi K, Yamamoto N, Hayashi K, Kimura H, Miwa S, Bouvet M, Tsuchiya H, Hoffman RM. PMID: 34848441.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    133. A Case of Rare Matrix-producing Triple-negative Breast Carcinoma for Which Drug Response in a Patient-derived Orthotopic Xenograft Mouse Model Was Correlated With Patient Response. Anticancer Res. 2021 Dec; 41(12):6191-6197. Nomura T, Kurebayashi J, Moriya T, Saito W, Murata T, Yamamoto J, Hozumi C, Hoffman RM. PMID: 34848473.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    134. Histone H3 lysine-trimethylation markers are decreased by recombinant methioninase and increased by methotrexate at concentrations which inhibit methionine-addicted osteosarcoma cell proliferation. Biochem Biophys Rep. 2021 Dec; 28:101177. Aoki Y, Tome Y, Han Q, Yamamoto J, Hamada K, Masaki N, Bouvet M, Nishida K, Hoffman RM. PMID: 34877414; PMCID: PMC8633566.
      View in: PubMed   Mentions: 9  
    135. Survival Response of Patients With Gastric Cancer Treated With Regional Arterial-Perfusion Chemotherapy Is Correlated With Borrmann Classification. Anticancer Res. 2021 Nov; 41(11):5507-5515. Ma YE, Liang X, Liu LI, Gao D, Yang T, Hoffman RM, Xu J. PMID: 34732421.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    136. Over-methylation of Histone H3 Lysines Is a Common Molecular Change Among the Three Major Types of Soft-tissue Sarcoma in Patient-derived Xenograft (PDX) Mouse Models. Cancer Genomics Proteomics. 2021 Nov-Dec; 18(6):715-721. Aoki Y, Yamamoto J, Tome Y, Hamada K, Masaki N, Inubushi S, Tashiro Y, Bouvet M, Endo I, Nishida K, Hoffman RM. PMID: 34697064; PMCID: PMC8569816.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    137. Salmonella typhimurium A1-R Exquisitely Targets and Arrests a Matrix-producing Triple-negative Breast Carcinoma in a PDOX Model. In Vivo. 2021 Nov-Dec; 35(6):3067-3071. Hamada K, Aoki Y, Yamamoto J, Hozumi C, Zhao M, Murata T, Sugisawa N, Bouvet M, Tsunoda T, Hoffman RM. PMID: 34697138; PMCID: PMC8627766.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    138. Osteosarcoma of the Breast in a Patient Derived Orthotopic Xenograft (PDOX) Mouse Model Is Arrested by both Cisplatinum and Eribulin. In Vivo. 2021 Nov-Dec; 35(6):3107-3110. Masaki N, Wu NF, Aoki Y, Yamamoto J, Miyazaki J, Hoffman RM. PMID: 34697141; PMCID: PMC8627742.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    139. Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19. Nat Commun. 2021 10 18; 12(1):6055. Boras B, Jones RM, Anson BJ, Arenson D, Aschenbrenner L, Bakowski MA, Beutler N, Binder J, Chen E, Eng H, Hammond H, Hammond J, Haupt RE, Hoffman R, Kadar EP, Kania R, Kimoto E, Kirkpatrick MG, Lanyon L, Lendy EK, Lillis JR, Logue J, Luthra SA, Ma C, Mason SW, McGrath ME, Noell S, Obach RS, O' Brien MN, O'Connor R, Ogilvie K, Owen D, Pettersson M, Reese MR, Rogers TF, Rosales R, Rossulek MI, Sathish JG, Shirai N, Steppan C, Ticehurst M, Updyke LW, Weston S, Zhu Y, White KM, García-Sastre A, Wang J, Chatterjee AK, Mesecar AD, Frieman MB, Anderson AS, Allerton C. PMID: 34663813; PMCID: PMC8523698.
      View in: PubMed   Mentions: 149     Fields:    Translation:HumansAnimalsCells
    140. The Combination of Cisplatinum and Doxorubicin Regressed Primary Osteosarcoma of the Breast in a PDOX Mouse Model. Anticancer Res. 2021 Oct; 41(10):4715-4718. Wu NF, Yamamoto J, Aoki Y, Masaki N, Samonte C, Wu J, Bouvet M, Hoffman RM. PMID: 34593419.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    141. Anti-inflammatory and Anti-thrombotic Efficacy of Targeted Ultrasound Microbubbles on LPS-induced HUVEC Cells. Anticancer Res. 2021 Oct; 41(10):4761-4769. Sun J, Pan S, Yu H, Hu H, Sun YU, Yang Z, Hoffman RM, Yuan H. PMID: 34593425.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    142. Antibiotic Usage Reduced Overall Survival by over 70% in Non-small Cell Lung Cancer Patients on Anti-PD-1 Immunotherapy. Anticancer Res. 2021 Oct; 41(10):4985-4993. Hamada K, Yoshimura K, Hirasawa Y, Hosonuma M, Murayama M, Narikawa Y, Ariizumi H, Ohkuma R, Shida M, Kubota Y, Matsukuma S, Ishiguro T, Sambe T, Horiike A, Kuramasu A, Wada S, Tsurutani J, Inoue E, Uchida N, Kiuchi Y, Kobayashi S, Hoffman RM, Tsunoda T. PMID: 34593446.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    143. Efficacy of Oral Recombinant Methioninase and Eribulin on a PDOX Model of Triple-negative Breast Cancer (TNBC) Liver Metastasis. In Vivo. 2021 Sep-Oct; 35(5):2531-2534. Lim HI, Sun YU, Han Q, Yamamoto J, Hoffman RM. PMID: 34410939; PMCID: PMC8408690.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    144. Multikinase-Inhibitor Screening in Drug-resistant Osteosarcoma Patient-derived Orthotopic Xenograft Mouse Models Identifies the Clinical Potential of Regorafenib. Cancer Genomics Proteomics. 2021 Sep-Oct; 18(5):637-643. Higuchi T, Igarashi K, Yamamoto N, Hayashi K, Kimura H, Miwa S, Bouvet M, Tsuchiya H, Hoffman RM. PMID: 34479916; PMCID: PMC8441758.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsPHPublic Health
    145. Five-day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers without toxicity in a clinical trial of normal-weight individuals. Clin Transl Med. 2021 08; 11(8):e502. Jiang Y, Yang X, Dong C, Lu Y, Yin H, Xiao B, Yang X, Chen W, Cheng W, Tian H, Guo L, Hu X, Fang H, Chen W, Li Z, Zhou W, Sun W, Guo X, Li S, Lin Y, He R, Chen X, Liu D, Zhang M, Zhang Y, Zhao H, Zheng P, Seyfried TN, Hoffman RM, Jia W, Ji G, Jia L. PMID: 34459130; PMCID: PMC8320652.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    146. Indocyanine Green Fluorescence Image-guided Laparoscopic Hepatectomy Enabled Resection of a Tumor Invisible With Ultrasonography. Anticancer Res. 2021 Aug; 41(8):3867-3869. Oura K, Aoki T, Tashiro Y, Matsuda K, Koizumi T, Kusano T, Wada Y, Shibata H, Yamashita T, Date H, Ariyoshi T, Goto S, Yamazaki K, Watanabe M, Fujimori A, Enami Y, Otsuka K, Hoffman RM, Murakami M. PMID: 34281847.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    147. Rapid tumor-labeling kinetics with a site-specific near-infrared anti-CEA nanobody in a patient-derived orthotopic xenograft mouse model of colon cancer. J Surg Oncol. 2021 Dec; 124(7):1121-1127. Lwin TM, Turner MA, Amirfakhri S, Nishino H, Debie P, Cosman BC, Hoffman RM, Hernot S, Bouvet M. PMID: 34309885; PMCID: PMC8556245.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    148. Combination of CDK4/6 and mTOR Inhibitors Suppressed Doxorubicin-resistant Osteosarcoma in a Patient-derived Orthotopic Xenograft Mouse Model: A Translatable Strategy for Recalcitrant Disease. Anticancer Res. 2021 Jul; 41(7):3287-3292. Oshiro H, Tome Y, Miyake K, Higuchi T, Sugisawa N, Kanaya F, Nishida K, Hoffman RM. PMID: 34230123.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    149. A Patient-Derived Orthotopic Xenograft Model of Gastroesophageal-Junction Adenocarcinoma Translated to the Clinic by Tumor-Targeting Fluorescent Antibodies to Carcinoembryonic-Antigen-Related Cell-Adhesion Molecules. In Vivo. 2021 Jul-Aug; 35(4):1959-1963. Turner MA, Amirfakhri S, Nishino H, Lwin TM, Savides TJ, Reid TR, Singer BB, Hoffman RM, Bouvet M. PMID: 34182469; PMCID: PMC8286470.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    150. The First Mouse Model of Primary Osteosarcoma of the Breast. In Vivo. 2021 Jul-Aug; 35(4):1979-1983. Wu NF, Wu J, Yamamoto J, Aoki Y, Hozumi C, Bouvet M, Hoffman RM. PMID: 34182472; PMCID: PMC8286515.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    151. Traditional Chinese Medicine Xihuang Wan Inhibited Lewis Lung Carcinoma in a Syngeneic Model, Equivalent to Cytotoxic Chemotherapy, by Altering Multiple Signaling Pathways. In Vivo. 2021 Jul-Aug; 35(4):2005-2014. Zhang Z, Wang J, Duan H, Liu D, Zhou X, Lin X, Pang H, Sun M, Zhou T, Hoffman RM, Hu K. PMID: 34182475; PMCID: PMC8286502.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    152. Chronic Treatment of an Advanced Prostate-cancer Patient With Oral Methioninase Resulted in Long-term Stabilization of Rapidly Rising PSA Levels. In Vivo. 2021 Jul-Aug; 35(4):2171-2176. Han Q, Hoffman RM. PMID: 34182494; PMCID: PMC8286516.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    153. Immuno-hyperthermia effected by antibody-conjugated nanoparticles selectively targets and eradicates individual cancer cells. Cell Cycle. 2021 07; 20(13):1221-1230. Kagawa T, Matsumi Y, Aono H, Ohara T, Tazawa H, Shigeyasu K, Yano S, Takeda S, Komatsu Y, Hoffman RM, Fujiwara T, Kishimoto H. PMID: 34148497; PMCID: PMC8330994.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    154. Effective Tumor Targeting by EphA2-Agonist-Biotin-Streptavidin Conjugates. Molecules. 2021 Jun 17; 26(12). Udompholkul P, Baggio C, Gambini L, Sun Y, Zhao M, Hoffman RM, Pellecchia M. PMID: 34204178; PMCID: PMC8235110.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    155. Fangchinoline Inhibits Human Esophageal Cancer by Transactivating ATF4 to Trigger Both Noxa-Dependent Intrinsic and DR5-Dependent Extrinsic Apoptosis. Front Oncol. 2021; 11:666549. Zhang Y, Wang S, Chen Y, Zhang J, Yang J, Xian J, Li L, Zhao H, Hoffman RM, Zhang Y, Jia L. PMID: 34195076; PMCID: PMC8236818.
      View in: PubMed   Mentions: 6  
    156. Hyperthermia generated by magnetic nanoparticles for effective treatment of disseminated peritoneal cancer in an orthotopic nude-mouse model. Cell Cycle. 2021 06; 20(12):1122-1133. Matsumi Y, Kagawa T, Yano S, Tazawa H, Shigeyasu K, Takeda S, Ohara T, Aono H, Hoffman RM, Fujiwara T, Kishimoto H. PMID: 34110969; PMCID: PMC8265816.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    157. Neddylation Regulates Macrophages and Implications for Cancer Therapy. Front Cell Dev Biol. 2021; 9:681186. Jiang Y, Li L, Li Y, Liu G, Hoffman RM, Jia L. PMID: 34164400; PMCID: PMC8215544.
      View in: PubMed   Mentions: 13  
    158. Exosome Transfer Between Pancreatic-cancer Cells Is Associated With Metastasis in a Nude-mouse Model. Anticancer Res. 2021 Jun; 41(6):2829-2834. Ichikawa H, Suetsugu A, Satake T, Aoki H, Kunisada T, Shimizu M, Hoffman RM. PMID: 34083272.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    159. Traditional Chinese Medicine Brucea Javanica Oil Enhances the Efficacy of Anlotinib in a Mouse Model of Liver-Metastasis of Small-cell Lung Cancer. In Vivo. 2021 May-Jun; 35(3):1437-1441. Peng S, Dong W, Chu Q, Meng J, Yang H, DU Y, Sun YU, Hoffman RM. PMID: 33910820; PMCID: PMC8193324.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    160. Efficacy of YAP1-gene Knockdown to Inhibit Alveolar-Epithelial-Cell Senescence and Alleviate Idiopathic Pulmonary Fibrosis (IPF). Cancer Genomics Proteomics. 2021 May-Jun; 18(3 Suppl):451-459. Xu W, Song W, Wang YU, Zan Y, Zhang M, Li M, Huang Q, Zhao W, Sun YU, Hoffman RM, Wu J. PMID: 33994367; PMCID: PMC8240039.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    161. Andrographolide Induces Noxa-Dependent Apoptosis by Transactivating ATF4 in Human Lung Adenocarcinoma Cells. Front Pharmacol. 2021; 12:680589. Zhang J, Li C, Zhang L, Heng Y, Xu T, Zhang Y, Chen X, Hoffman RM, Jia L. PMID: 33995110; PMCID: PMC8117100.
      View in: PubMed   Mentions: 6  
    162. An mTOR and VEGFR inhibitor combination arrests a doxorubicin resistant lung metastatic osteosarcoma in a PDOX mouse model. Sci Rep. 2021 04 21; 11(1):8583. Oshiro H, Tome Y, Miyake K, Higuchi T, Sugisawa N, Kanaya F, Nishida K, Hoffman RM. PMID: 33883561; PMCID: PMC8060249.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    163. Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Can Extensively Differentiate to Tyrosine-Hydroxylase-Expressing Dopamine-Secreting Neurons. Cells. 2021 04 10; 10(4). Yamane M, Takaoka N, Obara K, Shirai K, Aki R, Hamada Y, Arakawa N, Hoffman RM, Amoh Y. PMID: 33920157; PMCID: PMC8069047.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    164. A Novel Color-Coded Liver Metastasis Mouse Model to Distinguish Tumor and Adjacent Liver Segment. J Surg Res. 2021 08; 264:327-333. Nishino H, Hollandsworth HM, Amirfakhri S, Tashiro Y, Yamamoto J, Turner MA, Lwin TM, Singer BB, Hoffman RM, Bouvet M. PMID: 33848831; PMCID: PMC8222089.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    165. Lowering and Stabilizing PSA Levels in Advanced-prostate Cancer Patients With Oral Methioninase. Anticancer Res. 2021 Apr; 41(4):1921-1926. Han Q, Hoffman RM. PMID: 33813397.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCellsCTClinical Trials
    166. Eribulin Inhibits Osteosarcoma in a Clinically-accurate Bone-tumor-insertion PDOX Mouse Model. Anticancer Res. 2021 Apr; 41(4):1779-1784. Wu NF, Yamamoto J, Aoki Y, Bouvet M, Hoffman RM. PMID: 33813382.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    167. Oral-recombinant Methioninase Converts an Osteosarcoma from Docetaxel-resistant to -Sensitive in a Clinically-relevant Patient-derived Orthotopic-xenograft (PDOX) Mouse Model. Anticancer Res. 2021 Apr; 41(4):1745-1751. Aoki Y, Tome Y, Wu NF, Yamamoto J, Hamada K, Han Q, Bouvet M, Nishida K, Hoffman RM. PMID: 33813378.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    168. Oral recombinant methioninase combined with paclitaxel arrests recalcitrant ovarian clear cell carcinoma growth in a patient-derived orthotopic xenograft (PDOX) nude-mouse model. Cancer Chemother Pharmacol. 2021 07; 88(1):61-67. Sugisawa N, Higuchi T, Han Q, Hozumi C, Yamamoto J, Tashiro Y, Nishino H, Kawaguchi K, Bouvet M, Murata T, Unno M, Hoffman RM. PMID: 33768300.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    169. Overexpressed NEDD8 as a potential therapeutic target in esophageal squamous cell carcinoma. Cancer Biol Med. 2021 Mar 18. Xian J, Wang S, Jiang Y, Li L, Cai L, Chen P, Liu Y, Zeng X, Chen G, Ding C, Hoffman RM, Jia L, Zhao H, Zhang Y. PMID: 33733647; PMCID: PMC9088192.
      View in: PubMed   Mentions: 5     Fields:    
    170. The Experience of Greece as a Model to Contain COVID-19 Infection Spread. In Vivo. 2021 Mar-Apr; 35(2):1285-1294. Delinasios GJ, Fragkou PC, Gkirmpa AM, Tsangaris G, Hoffman RM, Anagnostopoulos AK. PMID: 33622932; PMCID: PMC8045105.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCellsPHPublic Health
    171. The Anti-oxidant Monoterpene p-Cymene Reduced the Occurrence of Colorectal Cancer in a Hyperlipidemia Rat Model by Reducing Oxidative Stress and Expression of Inflammatory Cytokines. Anticancer Res. 2021 Mar; 41(3):1213-1218. Wang S, Wang X, Wang YU, Leng Q, Sun YU, Hoffman RM, Jin H. PMID: 33788712.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    172. Combination Methionine-methylation-axis Blockade: A Novel Approach to Target the Methionine Addiction of Cancer. Cancer Genomics Proteomics. 2021 Mar-Apr; 18(2):113-120. Higuchi T, Han Q, Sugisawa N, Yamamoto J, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 33608308; PMCID: PMC7943212.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    173. Unique Benefits of Tumor-Specific Nanobodies for Fluorescence Guided Surgery. Biomolecules. 2021 02 18; 11(2). Lwin TM, Hoffman RM, Bouvet M. PMID: 33670740; PMCID: PMC7921980.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    174. A Novel Orthotopic Mouse Model of Lung Metastasis Using Fluorescent Patient-derived Osteosarcoma Cells. Anticancer Res. 2021 Feb; 41(2):635-640. Oshiro H, Tome Y, Miyake K, Higuchi T, Sugisawa N, Park JH, Zhang Z, Razmjooei S, Kanaya F, Nishida K, Hoffman RM. PMID: 33517267.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    175. Reversion from Methionine Addiction to Methionine Independence Results in Loss of Tumorigenic Potential of Highly-malignant Lung-cancer Cells. Anticancer Res. 2021 Feb; 41(2):641-643. Yamamoto J, Aoki Y, Han Q, Sugisawa N, Sun YU, Hamada K, Nishino H, Inubushi S, Miyake K, Matsuyama R, Bouvet M, Endo I, Hoffman RM. PMID: 33517268.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    176. Real-Time Fluorescence Image-Guided Oncolytic Virotherapy for Precise Cancer Treatment. Int J Mol Sci. 2021 Jan 17; 22(2). Yano S, Tazawa H, Kishimoto H, Kagawa S, Fujiwara T, Hoffman RM. PMID: 33477279; PMCID: PMC7830621.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    177. Triple-Methyl Blockade With Recombinant Methioninase, Cycloleucine, and Azacitidine Arrests a Pancreatic Cancer Patient-Derived Orthotopic Xenograft Model. Pancreas. 2021 01 01; 50(1):93-98. Sugisawa N, Yamamoto J, Han Q, Tan Y, Tashiro Y, Nishino H, Inubushi S, Hamada K, Kawaguchi K, Unno M, Bouvet M, Hoffman RM. PMID: 33370029.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    178. A Novel Procedure for Orthotopic Tibia Implantation for Establishment of a More Clinical Osteosarcoma PDOX Mouse Model. In Vivo. 2021 Jan-Feb; 35(1):105-109. Wu NF, Yamamoto J, Bouvet M, Hoffman RM. PMID: 33402455; PMCID: PMC7880751.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    179. Color-Coded Imaging of the Tumor Microenvironment (TME) in Human Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models. Adv Exp Med Biol. 2021; 1329:163-179. Suetsugu A, Hoffman RM. PMID: 34664239.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    180. Color-Coded Imaging of Cancer and Stromal-Cell Interaction in the Pancreatic-Cancer Tumor Microenvironment (TME). Methods Mol Biol. 2021; 2224:99-111. Suetsugu A, Hoffman RM. PMID: 33606209.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    181. A Universal Gelfoam 3-D Histoculture Method to Establish Patient-derived Cancer Cells (3D-PDCC) Without Fibroblasts from Patient-derived Xenografts. Anticancer Res. 2020 Dec; 40(12):6765-6768. Yamamoto J, Sugisawa N, Hamada K, Nishino H, Miyake K, Matsuyama R, Inubushi S, Tanino H, Bouvet M, Endo I, Hoffman RM. PMID: 33288569.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    182. A review of tumor-specific fluorescence-guided surgery for colorectal cancer. Surg Oncol. 2021 Mar; 36:84-90. Hollandsworth HM, Turner MA, Hoffman RM, Bouvet M. PMID: 33316684; PMCID: PMC7855598.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    183. A novel patient-derived orthotopic xenograft (PDOX) mouse model of highly-aggressive liver metastasis for identification of candidate effective drug-combinations. Sci Rep. 2020 11 18; 10(1):20105. Zhang Z, Hu K, Miyake K, Kiyuna T, Oshiro H, Wangsiricharoen S, Kawaguchi K, Higuchi T, Razmjooei S, Miyake M, Chawla SP, Singh SR, Hoffman RM. PMID: 33208807; PMCID: PMC7676248.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    184. Oral Recombinant Methioninase Sensitizes a Bladder Cancer Orthotopic Xenograft Mouse Model to Low-dose Cisplatinum and Prevents Metastasis. Anticancer Res. 2020 Nov; 40(11):6083-6091. Sun YU, Nishino H, Sugisawa N, Yamamoto J, Hamada K, Zhu G, Lim HI, Hoffman RM. PMID: 33109546.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    185. Sutureless Surgical Orthotopic Implantation Technique of Primary and Metastatic Cancer in the Liver of Mouse Models. In Vivo. 2020 Nov-Dec; 34(6):3153-3157. Nishino H, Hollandsworth HM, Sugisawa N, Yamamoto J, Tashiro Y, Inubushi S, Hamada K, Sun YU, Lim H, Amirfakhri S, Filemoni F, Hoffman RM, Bouvet M. PMID: 33144418; PMCID: PMC7811661.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    186. Ligation Method to Specifically Label a Liver Segment With Indocyanine Green in an Orthotopic Nude-Mouse Liver-Metastasis Model. In Vivo. 2020 Nov-Dec; 34(6):3159-3162. Nishino H, Hollandsworth HM, Tashiro Y, Yamamoto J, Amirfakhri S, Filemoni F, Sugisawa N, Hoffman RM, Bouvet M. PMID: 33144419; PMCID: PMC7811678.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    187. Response of Triple-negative Breast Cancer Liver Metastasis to Oral Recombinant Methioninase in a Patient-derived Orthotopic Xenograft (PDOX) Model. In Vivo. 2020 Nov-Dec; 34(6):3163-3169. Lim HI, Yamamoto J, Han Q, Sun YU, Nishino H, Tashiro Y, Sugisawa N, Tan Y, Choi HJ, Nam SJ, Bouvet M, Hoffman RM. PMID: 33144420; PMCID: PMC7811664.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    188. A Non-invasive Imageable GFP-expressing Mouse Model of Orthotopic Human Bladder Cancer. In Vivo. 2020 Nov-Dec; 34(6):3225-3231. Sun YU, Nishino H, Zhao M, Miyake K, Sugisawa N, Yamamoto J, Tashiro Y, Inubushi S, Hamada K, Zhu G, Lim H, Hoffman RM. PMID: 33144427; PMCID: PMC7811621.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    189. Co-implantation of Tumor and Extensive Surrounding Tissue Improved the Establishment Rate of Surgical Specimens of Human-Patient Cancer in Nude Mice: Toward the Goal of Universal Individualized Cancer Therapy. In Vivo. 2020 Nov-Dec; 34(6):3241-3245. Murata T, Hozumi C, Hiroshima Y, Shimoya K, Hongo A, Inubushi S, Tanino H, Hoffman RM. PMID: 33144429; PMCID: PMC7811650.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    190. Ischemia reperfusion-induced metastasis is resistant to PPARγ agonist pioglitazone in a murine model of colon cancer. Sci Rep. 2020 10 29; 10(1):18565. Tashiro Y, Nishino H, Higuchi T, Sugisawa N, Fukuda Y, Yamamoto J, Inubushi S, Aoki T, Murakami M, Singh SR, Bouvet M, Hoffman RM. PMID: 33122687; PMCID: PMC7596558.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    191. Histone methylation status of H3K4me3 and H3K9me3 under methionine restriction is unstable in methionine-addicted cancer cells, but stable in normal cells. Biochem Biophys Res Commun. 2020 12 17; 533(4):1034-1038. Yamamoto J, Han Q, Inubushi S, Sugisawa N, Hamada K, Nishino H, Miyake K, Kumamoto T, Matsuyama R, Bouvet M, Endo I, Hoffman RM. PMID: 33019978.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    192. Prostate Cancer Metastases Are Strongly Inhibited by Agonistic Epha2 Ligands in an Orthotopic Mouse Model. Cancers (Basel). 2020 Oct 02; 12(10). Salem AF, Gambini L, Billet S, Sun Y, Oshiro H, Zhao M, Hoffman RM, Bhowmick NA, Pellecchia M. PMID: 33023262; PMCID: PMC7600344.
      View in: PubMed   Mentions: 7  
    193. A Gemcitabine Plus 5-Fluorouracil Combination Inhibits Gastric-Cancer Liver Metastasis in a PDOX Model: A Novel Treatment Strategy. Anticancer Res. 2020 Oct; 40(10):5393-5397. Sugisawa N, Nishino H, Higuchi T, Park JH, Yamamoto J, Tashiro Y, Kawaguchi K, Bouvet M, Unno M, Hoffman RM. PMID: 32988858.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    194. Fluorescence-guided hepatobiliary surgery with long and short wavelength fluorophores. Hepatobiliary Surg Nutr. 2020 Oct; 9(5):615-639. Lwin TM, Hoffman RM, Bouvet M. PMID: 33163512; PMCID: PMC7603922.
      View in: PubMed   Mentions: 9  
    195. FUCCI Real-Time Cell-Cycle Imaging as a Guide for Designing Improved Cancer Therapy: A Review of Innovative Strategies to Target Quiescent Chemo-Resistant Cancer Cells. Cancers (Basel). 2020 Sep 17; 12(9). Yano S, Tazawa H, Kagawa S, Fujiwara T, Hoffman RM. PMID: 32957652; PMCID: PMC7563319.
      View in: PubMed   Mentions: 11  
    196. Adjuvant Oral Recombinant Methioninase Inhibits Lung Metastasis in a Surgical Breast-Cancer Orthotopic Syngeneic Model. Anticancer Res. 2020 Sep; 40(9):4869-4874. Sugisawa N, Hamada K, Han Q, Yamamoto J, Sun YU, Nishino H, Kawaguchi K, Bouvet M, Unno M, Hoffman RM. PMID: 32878774.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    197. Brucea javanica Increases Survival and Enhances Gemcitabine Efficacy in a Patient-derived Orthotopic Xenograft (PDOX) Mouse Model of Pancreatic Cancer. Anticancer Res. 2020 Sep; 40(9):4969-4978. Yang H, Tong Z, Shen L, Sun YU, Hoffman RM, Huang J. PMID: 32878785.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    198. Indocyanine Green Labels an Orthotopic Nude-Mouse Model of Very-Early Colon-Cancer Liver Metastases. In Vivo. 2020 Sep-Oct; 34(5):2277-2280. Tashiro Y, Hollandsworth HM, Nishino H, Yamamoto J, Amirfakhri S, Filemoni F, Sugisawa N, Aoki T, Murakami M, Hoffman RM, Bouvet M. PMID: 32871750; PMCID: PMC7652533.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    199. Oral Methioninase Inhibits Recurrence in a PDOX Mouse Model of Aggressive Triple-negative Breast Cancer. In Vivo. 2020 Sep-Oct; 34(5):2281-2286. Lim HI, Hamada K, Yamamoto J, Han Q, Tan Y, Choi HJ, Nam SJ, Bouvet M, Hoffman RM. PMID: 32871751; PMCID: PMC7652477.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    200. Humanized Fluorescent Tumor-associated Glycoprotein-72 Antibody Selectively Labels Colon-cancer Liver Metastases in Orthotopic Mouse Models. In Vivo. 2020 Sep-Oct; 34(5):2303-2307. Hollandsworth HM, Nishino H, Turner M, Amirfakhri S, Filemoni F, Hoffman RM, Yazaki PJ, Bouvet M. PMID: 32871754; PMCID: PMC7652487.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    201. An Improved Encapsulation Method for Cryopreserving Hepatocytes for Functional Transplantation Using a Thermo-reversible Gelation Polymer. In Vivo. 2020 Sep-Oct; 34(5):2309-2316. Yamada K, Aoki T, Enami Y, Tashiro Y, Zehaou Z, Koizumi T, Kusano T, Matsuda K, Wada Y, Shibata H, Tomioka K, Siriratsivawong K, Hoffman RM, Murakami M. PMID: 32871755; PMCID: PMC7652459.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    202. Fluorophore-conjugated Helicobacter pylori recombinant membrane protein (HopQ) labels primary colon cancer and metastases in orthotopic mouse models by binding CEA-related cell adhesion molecules. Transl Oncol. 2020 Dec; 13(12):100857. Hollandsworth HM, Schmitt V, Amirfakhri S, Filemoni F, Schmidt A, Landström M, Lyndin M, Backert S, Gerhard M, Wennemuth G, Hoffman RM, Singer BB, Bouvet M. PMID: 32866936; PMCID: PMC7475271.
      View in: PubMed   Mentions: 5  
    203. Oral recombinant methioninase increases TRAIL receptor-2 expression to regress pancreatic cancer in combination with agonist tigatuzumab in an orthotopic mouse model. Cancer Lett. 2020 11 01; 492:174-184. Yamamoto J, Miyake K, Han Q, Tan Y, Inubushi S, Sugisawa N, Higuchi T, Tashiro Y, Nishino H, Homma Y, Matsuyama R, Chawla SP, Bouvet M, Singh SR, Endo I, Hoffman RM. PMID: 32739322.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    204. The identification of candidate effective combination regimens for pancreatic cancer using the histoculture drug response assay. Sci Rep. 2020 07 20; 10(1):12004. Jun E, Park Y, Lee W, Kwon J, Lee S, Kim MB, Lee JS, Song KB, Hwang DW, Lee JH, Hoffman RM, Kim SC. PMID: 32686712; PMCID: PMC7371642.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    205. NEDD8-conjugating enzyme UBC12 as a novel therapeutic target in esophageal squamous cell carcinoma. Signal Transduct Target Ther. 2020 07 10; 5(1):123. Wang S, Xian J, Li L, Jiang Y, Liu Y, Cai L, Hoffman RM, Jia L, Zhao H, Zhang Y. PMID: 32651357; PMCID: PMC7351728.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    206. Osimertinib regressed an EGFR-mutant lung-adenocarcinoma bone-metastasis mouse model and increased long-term survival. Transl Oncol. 2020 Oct; 13(10):100826. Higuchi T, Sugisawa N, Park JH, Sun Y, Zhu G, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 32659740; PMCID: PMC7356269.
      View in: PubMed   Mentions: 6  
    207. Eribulin Regresses a Doxorubicin-resistant Dedifferentiated Liposarcoma in a Patient-derived Orthotopic Xenograft Mouse Model. Cancer Genomics Proteomics. 2020 Jul-Aug; 17(4):351-358. Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Higuchi T, Yamamoto N, Hayashi K, Kimura H, Miwa S, Singh SR, Tsuchiya H, Hoffman RM. PMID: 32576580; PMCID: PMC7367606.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    208. Pathological Validity of Using Near-infrared Fluorescence Imaging for Securing Surgical Margins During Liver Resection. Anticancer Res. 2020 Jul; 40(7):3873-3882. Tashiro Y, Aoki T, Hirai T, Koizumi T, Mansou DA, Kusano T, Matsuda K, Yamada K, Nogaki K, Hakozaki T, Wada Y, Shibata H, Tomioka K, Yamazaki T, Saito K, Fujimori A, Enami Y, Hoffman RM, Murakami M. PMID: 32620627.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    209. Near-infrared photoimmunotherapy is effective treatment for colorectal cancer in orthotopic nude-mouse models. PLoS One. 2020; 15(6):e0234643. Hollandsworth HM, Amirfakhri S, Filemoni F, Molnar J, Hoffman RM, Yazaki P, Bouvet M. PMID: 32555717; PMCID: PMC7302706.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    210. Oral Methioninase for Covid-19 Methionine-restriction Therapy. In Vivo. 2020 Jun; 34(3 Suppl):1593-1596. Hoffman RM, Han Q. PMID: 32503816; PMCID: PMC8378026.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCellsPHPublic Health
    211. Oncogenic miRNAs Identified in Tear Exosomes From Metastatic Breast Cancer Patients. Anticancer Res. 2020 06; 40(6):3091-3096. Inubushi S, Kawaguchi H, Mizumoto S, Kunihisa T, Baba M, Kitayama Y, Takeuchi T, Hoffman RM, Sasaki R. PMID: 32487603.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    212. The future of tumour-specific fluorescence-guided surgery for pancreatic cancer. Lancet Gastroenterol Hepatol. 2020 08; 5(8):715-717. Lwin TM, Hoffman RM, Bouvet M. PMID: 32416765; PMCID: PMC11057912.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    213. Myc is a prognostic biomarker and potential therapeutic target in osteosarcoma. Ther Adv Med Oncol. 2020; 12:1758835920922055. Feng W, Dean DC, Hornicek FJ, Spentzos D, Hoffman RM, Shi H, Duan Z. PMID: 32426053; PMCID: PMC7222246.
      View in: PubMed   Mentions: 38  
    214. Tumor-specific near-infrared nanobody probe rapidly labels tumors in an orthotopic mouse model of pancreatic cancer. Surgery. 2020 07; 168(1):85-91. Lwin TM, Hernot S, Hollandsworth H, Amirfakhri S, Filemoni F, Debie P, Hoffman RM, Bouvet M. PMID: 32370916; PMCID: PMC7311276.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    215. Eribulin Regresses a Cisplatinum-resistant Rare-type Triple-negative Matrix-producing Breast Carcinoma Patient-derived Orthotopic Xenograft Mouse Model. Anticancer Res. 2020 May; 40(5):2475-2479. Yamamoto J, Murata T, Sugisawa N, Higuchi T, Tashiro Y, Nishino H, Inubushi S, Sun YU, Lim H, Miyake K, Shimoya K, Nomura T, Kurebayashi J, Tanino H, Hozumi C, Bouvet M, Singh SR, Endo I, Hoffman RM. PMID: 32366391.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    216. A Single Low Dose of Eribulin Regressed a Highly Aggressive Triple-negative Breast Cancer in a Patient-derived Orthotopic Xenograft Model. Anticancer Res. 2020 May; 40(5):2481-2485. Lim HI, Yamamoto J, Inubushi S, Nishino H, Tashiro Y, Sugisawa N, Han Q, Sun YU, Choi HJ, Nam SJ, Kim MB, Lee JS, Hozumi C, Bouvet M, Singh SR, Hoffman RM. PMID: 32366392.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    217. A Triple-negative Matrix-producing Breast Carcinoma Patient-derived Orthotopic Xenograft (PDOX) Mouse Model Is Sensitive to Bevacizumab and Vinorelbine, Regressed by Eribulin and Resistant to Olaparib. Anticancer Res. 2020 May; 40(5):2509-2514. Yamamoto J, Murata T, Tashiro Y, Higuchi T, Sugisawa N, Nishino H, Inubushi S, Sun YU, Lim H, Miyake K, Hongo A, Nomura T, Saitoh W, Moriya T, Tanino H, Hozumi C, Bouvet M, Singh SR, Endo I, Hoffman RM. PMID: 32366395.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    218. Recombinant Methioninase Combined With Tumor-targeting Salmonella typhimurium A1-R Induced Regression in a PDOX Mouse Model of Doxorubicin-resistant Dedifferentiated Liposarcoma. Anticancer Res. 2020 May; 40(5):2515-2523. Igarashi K, Kawaguchi K, Zhao M, Han Q, Tan Y, Kiyuna T, Miyake K, Higuchi T, Nelson SD, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Singh SR, Tsuchiya H, Hoffman RM. PMID: 32366396.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    219. Oral dosing of Recombinant Methioninase Is Associated With a 70% Drop in PSA in a Patient With Bone-metastatic Prostate Cancer and 50% Reduction in Circulating Methionine in a High-stage Ovarian Cancer Patient. Anticancer Res. 2020 May; 40(5):2813-2819. Han Q, Tan Y, Hoffman RM. PMID: 32366428.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    220. A Novel Anionic-phosphate-platinum Complex Effectively Targets a Cisplatinum-resistant Osteosarcoma in a Patient-derived Orthotopic Xenograft Mouse Model. Cancer Genomics Proteomics. 2020 May-Jun; 17(3):217-223. Igarashi K, Kawaguchi K, Yamamoto N, Hayashi K, Kimura H, Miwa S, Higuchi T, Taniguchi Y, Yonezawa H, Araki Y, Morinaga S, Misra S, Nelson SD, Dry SM, Li Y, Odani A, Singh SR, Tsuchiya H, Hoffman RM. PMID: 32345663; PMCID: PMC7259888.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    221. Oral Recombinant Methioninase Inhibits Diabetes Onset in Mice on a High-fat Diet. In Vivo. 2020 May-Jun; 34(3):973-978. Tashiro Y, Han Q, Tan Y, Sugisawa N, Yamamoto J, Nishino H, Inubushi S, Sun YU, Zhu G, Lim H, Aoki T, Murakami M, Bouvet M, Hoffman RM. PMID: 32354882; PMCID: PMC7279799.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    222. Oral Recombinant Methioninase Prevents Nonalcoholic Fatty Liver Disease in Mice on a High Fat Diet. In Vivo. 2020 May-Jun; 34(3):979-984. Tashiro Y, Han Q, Tan Y, Sugisawa N, Yamamoto J, Nishino H, Inubushi S, Sun YU, Lim H, Aoki T, Murakami M, Takahashi Y, Bouvet M, Hoffman RM. PMID: 32354883; PMCID: PMC7279815.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    223. Comparison of the Efficacy of EGFR Tyrosine Kinase Inhibitors Erlotinib and Low-dose Osimertinib on a PC-9-GFP EGFR Mutant Non-small-cell Lung Cancer Growing in the Brain of Nude Mice. In Vivo. 2020 May-Jun; 34(3):1027-1030. Katsuya Y, Miyake K, Higuchi T, Oshiro H, Sugisawa N, Singh SR, Goto Y, Zhao M, Hoffman RM. PMID: 32354888; PMCID: PMC7279826.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    224. Humanized Anti-Tumor-Associated Glycoprotein-72 for Submillimeter Near-Infrared Detection of Colon Cancer in Metastatic Mouse Models. J Surg Res. 2020 08; 252:16-21. Hollandsworth HM, Amirfakhri S, Filemoni F, Hoffman RM, Molnar J, Yazaki PJ, Bouvet M. PMID: 32217350; PMCID: PMC7295682.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    225. Temozolomide and Pazopanib Combined with FOLFOX Regressed a Primary Colorectal Cancer in a Patient-derived Orthotopic Xenograft Mouse Model. Transl Oncol. 2020 Mar; 13(3):100739. Zhu G, Zhao M, Han Q, Tan Y, Sun Y, Bouvet M, Clary B, Singh SR, Ye J, Hoffman RM. PMID: 32143177; PMCID: PMC7058405.
      View in: PubMed   Mentions: 3  
    226. Oral Recombinant Methioninase Prevents Obesity in Mice on a High-fat Diet. In Vivo. 2020 Mar-Apr; 34(2):489-494. Tashiro Y, Han Q, Tan Y, Sugisawa N, Yamamoto J, Nishino H, Inubushi S, Higuchi T, Aoki T, Murakami M, Hoffman RM. PMID: 32111745; PMCID: PMC7157881.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    227. Pazopanib Inhibits Tumor Growth, Lymph-node Metastasis and Lymphangiogenesis of an Orthotopic Mouse of Colorectal Cancer. Cancer Genomics Proteomics. 2020 Mar-Apr; 17(2):131-139. Zhu G, Zhao M, Han Q, Tan Y, Sun YU, Bouvet M, Singh SR, Ye J, Hoffman RM. PMID: 32108035; PMCID: PMC7078832.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    228. APELA/ELA32 Reduces Iodixanol-induced Apoptosis, Inflammatory Response and Mitochondrial and DNA Damage in Renal Tubular Epithelial Cells. Anticancer Res. 2020 Feb; 40(2):635-643. Li Y, Huang J, He S, Lu Z, Zhang J, Li X, Yang Z, Hoffman RM, Wu Q. PMID: 32014904.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    229. Anti-carcinoembryonic antigen-related cell adhesion molecule antibody for fluorescence visualization of primary colon cancer and metastases in patient-derived orthotopic xenograft mouse models. Oncotarget. 2020 Jan 28; 11(4):429-439. Hollandsworth HM, Amirfakhri S, Filemoni F, Schmitt V, Wennemuth G, Schmidt A, Hoffman RM, Singer BB, Bouvet M. PMID: 32064046; PMCID: PMC6996915.
      View in: PubMed   Mentions: 18     Fields:    
    230. Effective targeting of the ubiquitin-like modifier NEDD8 for lung adenocarcinoma treatment. Cell Biol Toxicol. 2020 08; 36(4):349-364. Jiang Y, Cheng W, Li L, Zhou L, Liang Y, Zhang W, Chen W, Wang S, Zhao H, Chen G, Zhou W, Ji G, Zhang Y, Hoffman RM, Wang M, Jia L. PMID: 31907687.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    231. Collective cancer invasion forms an integrin-dependent radioresistant niche. J Exp Med. 2020 01 06; 217(1). Haeger A, Alexander S, Vullings M, Kaiser FMP, Veelken C, Flucke U, Koehl GE, Hirschberg M, Flentje M, Hoffman RM, Geissler EK, Kissler S, Friedl P. PMID: 31658985; PMCID: PMC7037234.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    232. TRAF6-Mediated Inflammatory Cytokines Secretion in LPS-induced Colorectal Cancer Cells Is Regulated by miR-140. Cancer Genomics Proteomics. 2020 Jan-Feb; 17(1):23-33. Zhu G, Lin C, Cheng Z, Wang Q, Hoffman RM, Singh SR, Huang Y, Zheng W, Yang S, Ye J. PMID: 31882548; PMCID: PMC6937127.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    233. PPARγ Agonist Pioglitazone in Combination With Cisplatinum Arrests a Chemotherapy-resistant Osteosarcoma PDOX Model. Cancer Genomics Proteomics. 2020 Jan-Feb; 17(1):35-40. Higuchi T, Yamamoto J, Sugisawa N, Tashiro Y, Nishino H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31882549; PMCID: PMC6937125.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    234. Relevance of Vitamin D in Melanoma Development, Progression and Therapy. Anticancer Res. 2020 Jan; 40(1):473-489. Brozyna AA, Hoffman RM, Slominski AT. PMID: 31892603; PMCID: PMC6948187.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    235. Exquisite Tumor Targeting by Salmonella A1-R in Combination with Caffeine and Valproic Acid Regresses an Adult Pleomorphic Rhabdomyosarcoma Patient-Derived Orthotopic Xenograft Mouse Model. Transl Oncol. 2020 Feb; 13(2):393-400. Igarashi K, Kawaguchi K, Zhao M, Kiyuna T, Miyake K, Miyake M, Nelson SD, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Higuchi T, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31896528; PMCID: PMC6940643.
      View in: PubMed   Mentions: 9  
    236. Combination of oral recombinant methioninase and decitabine arrests a chemotherapy-resistant undifferentiated soft-tissue sarcoma patient-derived orthotopic xenograft mouse model. Biochem Biophys Res Commun. 2020 02 26; 523(1):135-139. Higuchi T, Han Q, Miyake K, Oshiro H, Sugisawa N, Tan Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31839218.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    237. Combination of Trabectedin With Irinotecan, Leucovorin and 5-Fluorouracil Arrests Primary Colorectal Cancer in an Imageable Patient-derived Orthotopic Xenograft Mouse Model. Anticancer Res. 2019 Dec; 39(12):6463-6470. Zhu G, Zhao M, Han Q, Tan Y, Sun YU, Bouvet M, Clary B, Singh SR, Ye J, Hoffman RM. PMID: 31810910.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    238. The combination of oral-recombinant methioninase and azacitidine arrests a chemotherapy-resistant osteosarcoma patient-derived orthotopic xenograft mouse model. Cancer Chemother Pharmacol. 2020 02; 85(2):285-291. Higuchi T, Sugisawa N, Yamamoto J, Oshiro H, Han Q, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Tan Y, Kuchipudi S, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31705268.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    239. MyD88 Regulates LPS-induced NF-ĸB/MAPK Cytokines and Promotes Inflammation and Malignancy in Colorectal Cancer Cells. Cancer Genomics Proteomics. 2019 Nov-Dec; 16(6):409-419. Zhu G, Cheng Z, Lin C, Hoffman RM, Huang Y, Singh SR, Zheng W, Yang S, Ye J. PMID: 31659096; PMCID: PMC6885359.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    240. Double-negative T Cells Inhibit Proliferation and Invasion of Human Pancreatic Cancer Cells in Co-culture. Anticancer Res. 2019 Nov; 39(11):5911-5918. Lu Y, Hu P, Zhou H, Yang Z, Sun YU, Hoffman RM, Chen J. PMID: 31704815.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    241. Robo1-specific CAR-NK Immunotherapy Enhances Efficacy of 125I Seed Brachytherapy in an Orthotopic Mouse Model of Human Pancreatic Carcinoma. Anticancer Res. 2019 Nov; 39(11):5919-5925. Xia N, Haopeng P, Gong JU, Lu J, Chen Z, Zheng Y, Wang Z, Sun YU, Yang Z, Hoffman RM, Liu F. PMID: 31704816.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    242. Aurora-A/NF-ĸB Signaling Is Associated With Radio-resistance in Human Lung Adenocarcinoma. Anticancer Res. 2019 Nov; 39(11):5991-5998. Liu JB, Hu L, Yang Z, Sun YU, Hoffman RM, Yi Z. PMID: 31704824.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    243. Combination of Trabectedin With Oxaliplatinum and 5-Fluorouracil Arrests a Primary Colorectal Cancer in a Patient-derived Orthotopic Xenograft Mouse Model. Anticancer Res. 2019 Nov; 39(11):5999-6005. Zhu G, Zhao M, Han Q, Tan Y, Sun YU, Bouvet M, Singh SR, Ye J, Hoffman RM. PMID: 31704825.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    244. Novel targets identified by integrated cancer-stromal interactome analysis of pancreatic adenocarcinoma. Cancer Lett. 2020 01 28; 469:217-227. Hiroshima Y, Kasajima R, Kimura Y, Komura D, Ishikawa S, Ichikawa Y, Bouvet M, Yamamoto N, Oshima T, Morinaga S, Singh SR, Hoffman RM, Endo I, Miyagi Y. PMID: 31669204.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    245. Patient-derived orthotopic xenograft models of sarcoma. Cancer Lett. 2020 01 28; 469:332-339. Igarashi K, Kawaguchi K, Murakami T, Miyake K, Kiyuna T, Miyake M, Hiroshima Y, Higuchi T, Oshiro H, Nelson SD, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31639427.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    246. Induction of Metastasis by Low-dose Gemcitabine in a Pancreatic Cancer Orthotopic Mouse Model: An Opposite Effect of Chemotherapy. Anticancer Res. 2019 Oct; 39(10):5339-5344. Sugisawa N, Miyake K, Higuchi T, Oshiro H, Zhang Z, Park JH, Kawaguchi K, Chawla SP, Bouvet M, Singh SR, Unno M, Hoffman RM. PMID: 31570427.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    247. Oral recombinant methioninase combined with oxaliplatinum and 5-fluorouracil regressed a colon cancer growing on the peritoneal surface in a patient-derived orthotopic xenograft mouse model. Tissue Cell. 2019 Dec; 61:109-114. Park JH, Han Q, Zhao M, Tan Y, Higuchi T, Yoon SN, Sugisawa N, Yamamoto J, Bouvet M, Clary B, Singh SR, Hoffman RM. PMID: 31759402.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    248. AMMECR1 Inhibits Apoptosis and Promotes Cell-cycle Progression and Proliferation of the A549 Human Lung Cancer Cell Line. Anticancer Res. 2019 Sep; 39(9):4637-4642. Ge H, Cheng N, Xu X, Yang Z, Hoffman RM, Zhu J. PMID: 31519561.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    249. Oral Recombinant Methioninase, Combined With Oral Caffeine and Injected Cisplatinum, Overcome Cisplatinum-Resistance and Regresses Patient-derived Orthotopic Xenograft Model of Osteosarcoma. Anticancer Res. 2019 Sep; 39(9):4653-4657. Higuchi T, Oshiro H, Miyake K, Sugisawa N, Han Q, Tan Y, Park J, Zhang Z, Razmjooei S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Chawla SP, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31519563.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    250. Oral Recombinant Methioninase Overcomes Colorectal-cancer Liver Metastasis Resistance to the Combination of 5-Fluorouracil and Oxaliplatinum in a Patient-derived Orthotopic Xenograft Mouse Model. Anticancer Res. 2019 Sep; 39(9):4667-4671. Oshiro H, Tome Y, Kiyuna T, Yoon SN, Lwin TM, Han Q, Tan Y, Miyake K, Higuchi T, Sugisawa N, Katsuya Y, Park JH, Zang Z, Razmjooei S, Bouvet M, Clary B, Singh SR, Kanaya F, Nishida K, Hoffman RM. PMID: 31519565.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    251. Eribulin Suppressed Cisplatinum- and Doxorubicin-resistant Recurrent Lung Metastatic Osteosarcoma in a Patient-derived Orthotopic Xenograft Mouse Model. Anticancer Res. 2019 Sep; 39(9):4775-4779. Kiyuna T, Tome Y, Miyake K, Murakami T, Oshiro H, Igarashi K, Kawaguchi K, Hsu J, Singh M, Li Y, Nelson S, Bouvet M, Singh SR, Kanaya F, Hoffman RM. PMID: 31519578.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    252. Combination Treatment With Sorafenib and Everolimus Regresses a Doxorubicin-resistant Osteosarcoma in a PDOX Mouse Model. Anticancer Res. 2019 Sep; 39(9):4781-4786. Higuchi T, Sugisawa N, Miyake K, Oshiro H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Kline Z, Belt P, Chawla SP, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31519579.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    253. Pioglitazone, an agonist of PPARγ, reverses doxorubicin-resistance in an osteosarcoma patient-derived orthotopic xenograft model by downregulating P-glycoprotein expression. Biomed Pharmacother. 2019 Oct; 118:109356. Higuchi T, Sugisawa N, Miyake K, Oshiro H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Kline Z, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31545293.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    254. Efficacy of oral recombinant methioninase combined with oxaliplatinum and 5-fluorouracil on primary colon cancer in a patient-derived orthotopic xenograft mouse model. Biochem Biophys Res Commun. 2019 10 15; 518(2):306-310. Park JH, Zhao M, Han Q, Sun Y, Higuchi T, Sugisawa N, Yamamoto J, Singh SR, Clary B, Bouvet M, Hoffman RM. PMID: 31421825.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    255. High-Mobility Group Box 1 expression predicts survival of patients after resection of adenocarcinoma of the ampulla of Vater. World J Surg Oncol. 2019 Aug 09; 17(1):140. Murakami T, Matsuyama R, Ueda M, Mochizuki Y, Homma Y, Kameda K, Yazawa K, Izumisawa Y, Fukushima T, Kamimukai N, Yoshida K, Kamiya N, Hoffman RM, Endo I. PMID: 31399104; PMCID: PMC6689175.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    256. Color-coded Imaging of the Fate of Cancer-cell-derived Exosomes During Pancreatic Cancer Metastases in a Nude-mouse Model. Anticancer Res. 2019 Aug; 39(8):4055-4060. Satake T, Suetsugu A, Nakamura M, Kunisada T, Saji S, Moriwaki H, Shimizu M, Hoffman RM. PMID: 31366487.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    257. Choline-deficient-diet Decreases Fibroblasts in the Circulating Tumor Cell (CTC) Microenvironment. Anticancer Res. 2019 Aug; 39(8):4061-4064. Matsuura K, Suetsugu A, Satake T, Nakamura M, Kunisada T, Shimizu M, Hoffman RM. PMID: 31366488.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    258. Tumor-sealing Surgical Orthotopic Implantation of Human Colon Cancer in Nude Mice Induces Clinically-relevant Metastases Without Early Peritoneal Carcinomatosis. Anticancer Res. 2019 Aug; 39(8):4065-4071. Yoon SN, Park JH, Lwin TM, Miyake K, Singh SR, Hoffman RM, Bouvet M. PMID: 31366489; PMCID: PMC11058567.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    259. Sorafenib and Palbociclib Combination Regresses a Cisplatinum-resistant Osteosarcoma in a PDOX Mouse Model. Anticancer Res. 2019 Aug; 39(8):4079-4084. Higuchi T, Sugisawa N, Miyake K, Oshiro H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Chawla SP, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31366491.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    260. The Combination of Olaratumab with Doxorubicin and Cisplatinum Regresses a Chemotherapy-Resistant Osteosarcoma in a Patient-Derived Orthotopic Xenograft Mouse Model. Transl Oncol. 2019 Sep; 12(9):1257-1263. Higuchi T, Sugisawa N, Miyake K, Oshiro H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31299622; PMCID: PMC6624322.
      View in: PubMed   Mentions: 7  
    261. Peritoneal Metastases in a Patient-derived Orthotopic Xenograft (PDOX) Model of Colon Cancer Imaged Non-invasively via Red Fluorescent Protein Labeled Stromal Cells. Anticancer Res. 2019 Jul; 39(7):3463-3467. Park JH, Zhao M, Oshiro H, Miyake K, Higuchi T, Reynoso J, Razmjooei S, Bouvet M, Clary B, Zhang Z, Sugisawa N, Yamamoto J, Singh SR, Hoffman RM. PMID: 31262870.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    262. RE: "Intraoperative Near-infrared Imaging Can Identify Neoplasms and Aid in Real-time Margin Assessment During Pancreatic Resection". Ann Surg. 2019 07; 270(1):21-22. Bouvet M, Lwin TM, Hoffman RM. PMID: 31188174.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    263. Hair-follicle-associated pluripotent stem cells derived from cryopreserved intact human hair follicles sustain multilineage differentiation potential. Sci Rep. 2019 06 27; 9(1):9326. Obara K, Tohgi N, Mii S, Hamada Y, Arakawa N, Aki R, Singh SR, Hoffman RM, Amoh Y. PMID: 31249324; PMCID: PMC6597789.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    264. Promotion of tumor-associated macrophages infiltration by elevated neddylation pathway via NF-κB-CCL2 signaling in lung cancer. Oncogene. 2019 07; 38(29):5792-5804. Zhou L, Jiang Y, Liu X, Li L, Yang X, Dong C, Liu X, Lin Y, Li Y, Yu J, He R, Huang S, Liu G, Zhang Y, Jeong LS, Hoffman RM, Jia L. PMID: 31243299.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    265. Expression of anti-aging type-XVII collagen (COL17A1/BP180) in hair follicle-associated pluripotent (HAP) stem cells during differentiation. Tissue Cell. 2019 Aug; 59:33-38. Shirai K, Obara K, Tohgi N, Yamazaki A, Aki R, Hamada Y, Arakawa N, Singh SR, Hoffman RM, Amoh Y. PMID: 31383286.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    266. Efficacy of Tumor-Targeting Salmonella typhimurium A1-R against Malignancies in Patient-Derived Orthotopic Xenograft (PDOX) Murine Models. Cells. 2019 06 16; 8(6). Murakami T, Hiroshima Y, Miyake K, Kiyuna T, Endo I, Zhao M, Hoffman RM. PMID: 31208120; PMCID: PMC6628209.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    267. The combination of gemcitabine and docetaxel arrests a doxorubicin-resistant dedifferentiated liposarcoma in a patient-derived orthotopic xenograft model. Biomed Pharmacother. 2019 Sep; 117:109093. Miyake K, Higuchi T, Oshiro H, Zhang Z, Sugisawa N, Park JH, Razmjooei S, Katsuya Y, Barangi M, Li Y, Nelson SD, Murakami T, Homma Y, Hiroshima Y, Matsuyama R, Bouvet M, Chawla SP, Singh SR, Endo I, Hoffman RM. PMID: 31200257.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    268. Knockdown of Histone Methyltransferase WHSC1 Induces Apoptosis and Inhibits Cell Proliferation and Tumorigenesis in Salivary Adenoid Cystic Carcinoma. Anticancer Res. 2019 Jun; 39(6):2729-2737. Liu C, Jiang YH, Zhao ZL, Wu HW, Zhang L, Yang Z, Hoffman RM, Zheng JW. PMID: 31177108.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    269. Traditional Chinese Medicine (TCM) Astragalus Membranaceus and Curcuma Wenyujin Promote Vascular Normalization in Tumor-derived Endothelial Cells of Human Hepatocellular Carcinoma. Anticancer Res. 2019 Jun; 39(6):2739-2747. Zang W, Bian H, Huang X, Yin G, Zhang C, Han LI, Hao P, Ding S, Sun YU, Yang Z, Hoffman RM, Tang D. PMID: 31177109.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    270. Improved antibody-guided surgery with a near-infrared dye on a pegylated linker for CEA-positive tumors. J Biomed Opt. 2019 06; 24(6):1-9. Yazaki P, Lwin T, Minnix M, Li L, Sherman A, Molnar J, Miller A, Frankel P, Chea J, Poku E, Bowles N, Hoffman R, Shively J, Bouvet M. PMID: 31254333; PMCID: PMC6978469.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    271. Cyt-Geist: Current and Future Challenges in Cytometry: Reports of the CYTO 2018 Conference Workshops. Cytometry A. 2019 06; 95(6):598-644. Czechowska K, Lannigan J, Wang L, Arcidiacono J, Ashhurst TM, Barnard RM, Bauer S, Bispo C, Bonilla DL, Brinkman RR, Cabanski M, Chang HD, Chakrabarti L, Chojnowski G, Cotleur B, Degheidy H, Dela Cruz GV, Eck S, Elliott J, Errington R, Filby A, Gagnon D, Gardner R, Green C, Gregory M, Groves CJ, Hall C, Hammes F, Hedrick M, Hoffman R, Icha J, Ivaska J, Jenner DC, Jones D, Kerckhof FM, Kukat C, Lanham D, Leavesley S, Lee M, Lin-Gibson S, Litwin V, Liu Y, Molloy J, Moore JS, Müller S, Nedbal J, Niesner R, Nitta N, Ohlsson-Wilhelm B, Paul NE, Perfetto S, Portat Z, Props R, Radtke S, Rayanki R, Rieger A, Rogers S, Rubbens P, Salomon R, Schiemann M, Sharpe J, Sonder SU, Stewart JJ, Sun Y, Ulrich H, Van Isterdael G, Vitaliti A, van Vreden C, Weber M, Zimmermann J, Vacca G, Wallace P, Tárnok A. PMID: 31207046.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    272. Targeting neddylation inhibits intravascular survival and extravasation of cancer cells to prevent lung-cancer metastasis. Cell Biol Toxicol. 2019 06; 35(3):233-245. Jiang Y, Liang Y, Li L, Zhou L, Cheng W, Yang X, Yang X, Qi H, Yu J, Jeong LS, Hoffman RM, Zheng P, Jia L. PMID: 31140025.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    273. Anti-Claudin-1 Conjugated to a Near-Infrared Fluorophore Targets Colon Cancer in PDOX Mouse Models. J Surg Res. 2019 10; 242:145-150. Hollandsworth HM, Lwin TM, Amirfakhri S, Filemoni F, Batra SK, Hoffman RM, Dhawan P, Bouvet M. PMID: 31077946; PMCID: PMC7144806.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    274. Pazopanib regresses a doxorubicin-resistant synovial sarcoma in a patient-derived orthotopic xenograft mouse model. Tissue Cell. 2019 Jun; 58:107-111. Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyake M, Nelson SD, Russell TA, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Higuchi T, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31133237.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    275. Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review. Cells. 2019 05 02; 8(5). Kawaguchi K, Han Q, Li S, Tan Y, Igarashi K, Murakami T, Unno M, Hoffman RM. PMID: 31052611; PMCID: PMC6562625.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    276. Tumor-targeting Salmonella typhimurium A1-R overcomes nab-paclitaxel resistance in a cervical cancer PDOX mouse model. Arch Gynecol Obstet. 2019 06; 299(6):1683-1690. Miyake K, Murata T, Murakami T, Zhao M, Kiyuna T, Kawaguchi K, Igarashi K, Miyake M, Lwin TM, Hozumi C, Komatsu S, Kikuchi T, Bouvet M, Shimoya K, Singh SR, Endo I, Hoffman RM. PMID: 30953192; PMCID: PMC11066583.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    277. Trabectedin and irinotecan combination regresses a cisplatinum-resistant osteosarcoma in a patient-derived orthotopic xenograft nude-mouse model. Biochem Biophys Res Commun. 2019 May 28; 513(2):326-331. Higuchi T, Miyake K, Oshiro H, Sugisawa N, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Chawla SP, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 30955860.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    278. Temozolomide targets and arrests a doxorubicin-resistant follicular dendritic-cell sarcoma patient-derived orthotopic xenograft mouse model. Tissue Cell. 2019 Jun; 58:17-23. Oshiro H, Tome Y, Kiyuna T, Miyake K, Kawaguchi K, Higuchi T, Miyake M, Zang Z, Razmjooei S, Barangi M, Wangsiricharoen S, Nelson SD, Li Y, Bouvet M, Singh SR, Kanaya F, Hoffman RM. PMID: 31133242.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    279. Chemo-resistant Gastric Cancer Associated Gene Expression Signature: Bioinformatics Analysis Based on Gene Expression Omnibus. Anticancer Res. 2019 Apr; 39(4):1689-1698. Liu JB, Jian T, Yue C, Chen D, Chen W, Bao TT, Liu HX, Cao Y, Li WB, Yang Z, Hoffman RM, Yu C. PMID: 30952707.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    280. P-Glycoprotein Overexpression Is Associated With Cisplatin Resistance in Human Osteosarcoma. Anticancer Res. 2019 Apr; 39(4):1711-1718. He C, Sun Z, Hoffman RM, Yang Z, Jiang Y, Wang L, Hao Y. PMID: 30952710.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    281. Surgical and histological boundary of the hepatic hilar plate system: basic study relevant to surgery for hilar cholangiocarcinoma regarding the "true" proximal ductal margin. J Hepatobiliary Pancreat Sci. 2019 May; 26(5):159-168. Kikuchi Y, Matuyama R, Hiroshima Y, Murakami T, Bouvet M, Morioka D, Hoffman RM, Endo I. PMID: 30825363.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    282. The combination of olaratumab with gemcitabine and docetaxel arrests a chemotherapy-resistant undifferentiated soft-tissue sarcoma in a patient-derived orthotopic xenograft mouse model. Cancer Chemother Pharmacol. 2019 06; 83(6):1075-1082. Higuchi T, Miyake K, Sugisawa N, Oshiro H, Zhang Z, Razmjooei S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 30929053.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    283. Olaratumab combined with doxorubicin and ifosfamide overcomes individual doxorubicin and olaratumab resistance of an undifferentiated soft-tissue sarcoma in a PDOX mouse model. Cancer Lett. 2019 06 01; 451:122-127. Higuchi T, Miyake K, Sugisawa N, Oshiro H, Zhang Z, Razmjooei S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 30867142.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    284. β-Catenin Expression Correlates With Prognosis in Hepatocellular Carcinoma Patients Treated With Transcatheter Arterial Chemoembolization. Anticancer Res. 2019 Mar; 39(3):1129-1134. Xu X, Gao D, Yuan X, Liu LI, Zhang X, Liang X, Chen S, Ai M, Chen BO, Shi D, Yang Z, Hoffman RM, Xu J. PMID: 30842141.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    285. A patient-derived orthotopic xenograft (PDOX) nude-mouse model precisely identifies effective and ineffective therapies for recurrent leiomyosarcoma. Pharmacol Res. 2019 04; 142:169-175. Zhang Z, Hu K, Kiyuna T, Miyake K, Kawaguchi K, Igarashi K, Nelson SD, Li Y, Singh SR, Hoffman RM. PMID: 30807865.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    286. Osimertinib Regresses an EGFR-Mutant Cisplatinum- Resistant Lung Adenocarcinoma Growing in the Brain in Nude Mice. Transl Oncol. 2019 Apr; 12(4):640-645. Higuchi T, Oshiro H, Zhang Z, Miyake K, Sugisawa N, Katsuya Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Zhao M, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 30807997; PMCID: PMC6393699.
      View in: PubMed   Mentions: 6  
    287. Regorafenib regressed a doxorubicin-resistant Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude mouse model. Cancer Chemother Pharmacol. 2019 05; 83(5):809-815. Miyake K, Kiyuna T, Kawaguchi K, Higuchi T, Oshiro H, Zhang Z, Wangsiricharoen S, Razmjooei S, Li Y, Nelson SD, Murakami T, Hiroshima Y, Matsuyama R, Bouvet M, Chawla SP, Singh SR, Endo I, Hoffman RM. PMID: 30758647.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    288. Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Encapsulated on Polyvinylidene Fluoride Membranes (PFM) Promote Functional Recovery from Spinal Cord Injury. Stem Cell Rev Rep. 2019 02; 15(1):59-66. Obara K, Tohgi N, Shirai K, Mii S, Hamada Y, Arakawa N, Aki R, Singh SR, Hoffman RM, Amoh Y. PMID: 30341634.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    289. Combining Tumor-Selective Bacterial Therapy with Salmonella typhimurium A1-R and Cancer Metabolism Targeting with Oral Recombinant Methioninase Regressed an Ewing's Sarcoma in a Patient-Derived Orthotopic Xenograft Model. Chemotherapy. 2018; 63(5):278-283. Miyake K, Kiyuna T, Li S, Han Q, Tan Y, Zhao M, Oshiro H, Kawaguchi K, Higuchi T, Zhang Z, Razmjooei S, Barangi M, Wangsiricharoen S, Murakami T, Singh AS, Li Y, Nelson SD, Eilber FC, Bouvet M, Hiroshima Y, Chishima T, Matsuyama R, Singh SR, Endo I, Hoffman RM. PMID: 30673664.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    290. Gemcitabine combined with docetaxel precisely regressed a recurrent leiomyosarcoma peritoneal metastasis in a patient-derived orthotopic xenograft (PDOX) model. Biochem Biophys Res Commun. 2019 02 19; 509(4):1041-1046. Miyake K, Kiyuna T, Miyake M, Kawaguchi K, Zhang Z, Wangsiricharoen S, Razmjooei S, Oshiro H, Higuchi T, Li Y, Nelson SD, Murakami T, Hiroshima Y, Kumamoto T, Matsuyama R, Bouvet M, Singh SR, Chawla SP, Endo I, Hoffman RM. PMID: 30660363.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    291. The combination of gemcitabine and nab-paclitaxel as a novel effective treatment strategy for undifferentiated soft-tissue sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model. Biomed Pharmacother. 2019 Mar; 111:835-840. Higuchi T, Kawaguchi K, Miyake K, Oshiro H, Zhang Z, Razmjooei S, Wangsiricharoen S, Igarashi K, Yamamoto N, Hayashi K, Kimura H, Miwa S, Nelson SD, Dry SM, Li Y, Chawla SP, Eilber FC, Singh SR, Tsuchiya H, Hoffman RM. PMID: 30616082.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    292. Role of the tumor microenvironment in pancreatic cancer. Ann Gastroenterol Surg. 2019 Mar; 3(2):130-137. Murakami T, Hiroshima Y, Matsuyama R, Homma Y, Hoffman RM, Endo I. PMID: 30923782; PMCID: PMC6422798.
      View in: PubMed   Mentions: 62  
    293. Detection of Metastasis in a Patient-derived Orthotopic Xenograft (PDOX) Model of Undifferentiated Pleomorphic Sarcoma with Red Fluorescent Protein. Anticancer Res. 2019 Jan; 39(1):81-85. Oshiro H, Kiyuna T, Tome Y, Miyake K, Kawaguchi K, Higuchi T, Miyake M, Zhang Z, Razmjooei S, Barangi M, Wangsiricharoen S, Nelson SD, Li Y, Bouvet M, Singh SR, Kanaya F, Hoffman RM. PMID: 30591443.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    294. Altered Methionine Metabolism in Cancer Cells. Methods Mol Biol. 2019; 1866:13-26. Hoffman RM, Stern PH, Coalson DW, Douglas Wallace C, Erbe RW. PMID: 30725404.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    295. Linkage of Methionine Dependence and Other Features of Malignancy. Methods Mol Biol. 2019; 1866:27-36. Hoffman RM, Erbe RW. PMID: 30725405.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    296. Tumor-Specific S/G2-Phase Cell Cycle Arrest of Cancer Cells by Methionine Restriction. Methods Mol Biol. 2019; 1866:49-60. Hoffman RM, Yano S. PMID: 30725407.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    297. Efficacy of Methionine-Restricted Diets on Cancers In Vivo. Methods Mol Biol. 2019; 1866:75-81. Hoffman RM, Hoshiya Y, Guo W. PMID: 30725409.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    298. Dietary Methionine Restriction-Based Cancer Chemotherapy in Rodents. Methods Mol Biol. 2019; 1866:83-94. Hoffman RM, Stern PH. PMID: 30725410.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    299. Clinical Studies of Methionine-Restricted Diets for Cancer Patients. Methods Mol Biol. 2019; 1866:95-105. Hoffman RM. PMID: 30725411.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    300. Development of Recombinant Methioninase for Cancer Treatment. Methods Mol Biol. 2019; 1866:107-131. Hoffman RM, Tan Y, Li S, Han Q, Yagi S, Takakura T, Takimoto A, Inagaki K, Kudou D. PMID: 30725412.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    301. Methioninase Cell-Cycle Trap Cancer Chemotherapy. Methods Mol Biol. 2019; 1866:133-148. Hoffman RM, Yano S, Igarashi K. PMID: 30725413.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    302. High Efficacy of Recombinant Methioninase on Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Cancer. Methods Mol Biol. 2019; 1866:149-161. Hoffman RM, Murakami T, Kawaguchi K, Igarashi K, Tan Y, Li S, Han Q. PMID: 30725414.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    303. Total Methionine Restriction Treatment of Cancer. Methods Mol Biol. 2019; 1866:163-171. Hoffman RM, Kokkinakis DM, Frenkel EP. PMID: 30725415.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    304. Methioninase Gene Therapy. Methods Mol Biol. 2019; 1866:173-197. Hoffman RM, Miki K, Al-Refaie W, Xu M, Tan Y. PMID: 30725416.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    305. Safety and Toxicity of Recombinant Methioninase and Polyethylene Glycol (PEG) Recombinant Methioninase in Primates. Methods Mol Biol. 2019; 1866:211-229. Hoffman RM, Yang Z, Tan Y, Han Q, Li S, Yagi S. PMID: 30725418.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    306. Pilot Phase I Clinical Trial of Methioninase on High-Stage Cancer Patients: Rapid Depletion of Circulating Methionine. Methods Mol Biol. 2019; 1866:231-242. Hoffman RM, Tan Y, Li S, Han Q, Zavala J, Zavala J. PMID: 30725419.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCellsCTClinical Trials
    307. Methionine Restriction and Life-Span Extension. Methods Mol Biol. 2019; 1866:263-266. Hoffman RM. PMID: 30725421.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    308. L-[Methyl-11C] Methionine-Positron-Emission Tomography (MET-PET). Methods Mol Biol. 2019; 1866:267-271. Hoffman RM. PMID: 30725422.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    309. Is the Hoffman Effect for Methionine Overuse Analogous to the Warburg Effect for Glucose Overuse in Cancer? Methods Mol Biol. 2019; 1866:273-278. Hoffman RM. PMID: 30725423.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    310. Recombinant Methioninase as a DNA Demethylation Agent. Methods Mol Biol. 2019; 1866:279-284. Hoffman RM, Machover D. PMID: 30725424.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    311. Afterword: Oral Methioninase-Answer to Cancer and Fountain of Youth? Methods Mol Biol. 2019; 1866:311-322. Hoffman RM, Han Q, Kawaguchi K, Li S, Tan Y. PMID: 30725426.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    312. Human Hair Follicle Associated-Pluripotent (hHAP) Stem Cells Differentiate to Cardiac Muscle Cells. Methods Mol Biol. 2019; 1879:385-392. Hoffman RM. PMID: 29992514.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    313. Fluorescent humanized anti-CEA antibody specifically labels metastatic pancreatic cancer in a patient-derived orthotopic xenograft (PDOX) mouse model. Oncotarget. 2018 Dec 18; 9(99):37333-37342. Lwin TM, Miyake K, Murakami T, DeLong JC, Amirfakhri S, Filemoni F, Yoon SN, Yazaki PJ, Shivley JE, Datnow B, Clary BM, Hoffman RM, Bouvet M. PMID: 30647873; PMCID: PMC6324662.
      View in: PubMed   Mentions: 12     Fields:    
    314. Fluorescent Proteins as Sensors for Cellular Behavior in Mice. Prog Mol Biol Transl Sci. 2018; 160:29-45. Hoffman RM. PMID: 30470291.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    315. Metabolic targeting with recombinant methioninase combined with palbociclib regresses a doxorubicin-resistant dedifferentiated liposarcoma. Biochem Biophys Res Commun. 2018 12 02; 506(4):912-917. Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyaki M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Higuchi T, Singh AS, Chmielowski B, Nelson SD, Russell TA, Eckardt MA, Dry SM, Li Y, Singh SR, Chawla SP, Eilber FC, Tsuchiya H, Hoffman RM. PMID: 30392912.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    316. Hair Follicle-Associated Pluripotent(HAP) Stem Cells. Prog Mol Biol Transl Sci. 2018; 160:23-28. Hoffman RM, Amoh Y. PMID: 30470290.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    317. Real-Time Determination of the Cell-Cycle Position of Individual Cells within Live Tumors Using FUCCI Cell-Cycle Imaging. Cells. 2018 Oct 14; 7(10). Yano S, Hoffman RM. PMID: 30322204; PMCID: PMC6210921.
      View in: PubMed   Mentions: 13     Fields:    
    318. A combination of irinotecan/cisplatinum and irinotecan/temozolomide or tumor-targeting Salmonella typhimurium A1-R arrest doxorubicin- and temozolomide-resistant myxofibrosarcoma in a PDOX mouse model. Biochem Biophys Res Commun. 2018 11 02; 505(3):733-739. Kiyuna T, Tome Y, Murakami T, Miyake K, Igarashi K, Kawaguchi K, Oshiro H, Higuchi T, Miyake M, Sugisawa N, Zhang Z, Razmjooei S, Wangsiricharoen S, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Eckardt MA, Singh AS, Chawla S, Kanaya F, Eilber FC, Singh SR, Zhao M, Hoffman RM. PMID: 30292411.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    319. Color-coded Imaging of the Circulating Tumor Cell Microenvironment. Anticancer Res. 2018 Oct; 38(10):5635-5638. Satake T, Suetsugu A, Nakamura M, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. PMID: 30275181.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    320. Oral Recombinant Methioninase Combined with Caffeine and Doxorubicin Induced Regression of a Doxorubicin-resistant Synovial Sarcoma in a PDOX Mouse Model. Anticancer Res. 2018 Oct; 38(10):5639-5644. Higuchi T, Kawaguchi K, Miyake K, Han Q, Tan Y, Oshiro H, Sugisawa N, Zhang Z, Razmjooei S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Chawla SP, Singh AS, Eilber FC, Singh SR, Tsuchiya H, Hoffman RM. PMID: 30275182.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    321. Tumor targeting Salmonella typhimurium A1-R in combination with gemcitabine (GEM) regresses partially GEM-resistant pancreatic cancer patient-derived orthotopic xenograft (PDOX) nude mouse models. Cell Cycle. 2018; 17(16):2019-2026. Kawaguchi K, Miyake K, Zhao M, Kiyuna T, Igarashi K, Miyake M, Higuchi T, Oshiro H, Bouvet M, Unno M, Hoffman RM. PMID: 29963961; PMCID: PMC6224272.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    322. Tumor-targeting Salmonella typhimurium A1-R overcomes partial carboplatinum-resistance of a cancer of unknown primary (CUP). Tissue Cell. 2018 Oct; 54:144-149. Miyake K, Kiyuna T, Miyake M, Zhao M, Wangsiricharoen S, Kawaguchi K, Zhang Z, Higuchi T, Razmjooei S, Li Y, Nelson SD, Russell T, Singh A, Murakami T, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Singh SR, Chawla SP, Eilber FC, Endo I, Hoffman RM. PMID: 30309504.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    323. Ultrasound Microbubble Delivery Targeting Intraplaque Neovascularization Inhibits Atherosclerotic Plaque in an APOE-deficient Mouse Model. In Vivo. 2018 Sep-Oct; 32(5):1025-1032. Yuan H, Hu H, Sun J, Shi M, Yu H, Li C, Sun YU, Yang Z, Hoffman RM. PMID: 30150423; PMCID: PMC6199608.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    324. Combination therapy of tumor-targeting Salmonella typhimurium A1-R and oral recombinant methioninase regresses a BRAF-V600E-negative melanoma. Biochem Biophys Res Commun. 2018 09 18; 503(4):3086-3092. Kawaguchi K, Higuchi T, Li S, Han Q, Tan Y, Igarashi K, Zhao M, Miyake K, Kiyuna T, Miyake M, Ohshiro H, Sugisawa N, Zhang Z, Razmjooei S, Wangsiricharoen S, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Eckardt MA, Singh AS, Singh SR, Eilber FC, Unno M, Hoffman RM. PMID: 30166061.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    325. Imaging the interaction of αv integrin-GFP in osteosarcoma cells with RFP-expressing host stromal cells and tumor-scaffold collagen in the primary and metastatic tumor microenvironment. J Cell Biochem. 2019 01; 120(1):283-289. Tome Y, Kiyuna T, Uehara F, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM. PMID: 30145815.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    326. Patterns of sensitivity to a panel of drugs are highly individualised for undifferentiated/unclassified soft tissue sarcoma (USTS) in patient-derived orthotopic xenograft (PDOX) nude-mouse models. J Drug Target. 2019 02; 27(2):211-216. Kawaguchi K, Igarashi K, Miyake K, Kiyuna T, Miyake M, Singh AS, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Unno M, Singh SR, Eilber FC, Hoffman RM. PMID: 30024282.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    327. Trabectedin arrests a doxorubicin-resistant PDGFRA-activated liposarcoma patient-derived orthotopic xenograft (PDOX) nude mouse model. BMC Cancer. 2018 Aug 20; 18(1):840. Kiyuna T, Tome Y, Murakami T, Kawaguchi K, Igarashi K, Miyake K, Miyake M, Li Y, Nelson SD, Dry SM, Singh AS, Russell TA, Elliott I, Singh SR, Kanaya F, Eilber FC, Hoffman RM. PMID: 30126369; PMCID: PMC6102848.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    328. Advantages of patient-derived orthotopic mouse models and genetic reporters for developing fluorescence-guided surgery. J Surg Oncol. 2018 Aug; 118(2):253-264. Lwin TM, Hoffman RM, Bouvet M. PMID: 30080930; PMCID: PMC6146062.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    329. White paper on microbial anti-cancer therapy and prevention. J Immunother Cancer. 2018 08 06; 6(1):78. Forbes NS, Coffin RS, Deng L, Evgin L, Fiering S, Giacalone M, Gravekamp C, Gulley JL, Gunn H, Hoffman RM, Kaur B, Liu K, Lyerly HK, Marciscano AE, Moradian E, Ruppel S, Saltzman DA, Tattersall PJ, Thorne S, Vile RG, Zhang HH, Zhou S, McFadden G. PMID: 30081947; PMCID: PMC6091193.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    330. Intravital microscopy of osteolytic progression and therapy response of cancer lesions in the bone. Sci Transl Med. 2018 08 01; 10(452). Dondossola E, Alexander S, Holzapfel BM, Filippini S, Starbuck MW, Hoffman RM, Navone N, De-Juan-Pardo EM, Logothetis CJ, Hutmacher DW, Friedl P. PMID: 30068572; PMCID: PMC6326183.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    331. Color-coded Imaging Distinguishes Cancer Cells, Stromal Cells, and Recombinant Cancer-stromal Cells in the Tumor Microenvironment During Metastasis. Anticancer Res. 2018 Aug; 38(8):4417-4423. Nakamura M, Suetsugu A, Hasegawa K, Satake T, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. PMID: 30061205.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    332. Analysis of Anticancer Activity and Chemical Sensitization Effects of Dendropanax morbifera and Commersonia bartramia Extracts. Anticancer Res. 2018 Jul; 38(7):3853-3861. Kim S, Park SG, Song YJ, Park JK, Choi CH, Lee S, Hoffman RM. PMID: 29970505.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    333. Tumor-targeting Salmonella typhimurium A1-R arrests a doxorubicin-resistant PDGFRA-amplified patient-derived orthotopic xenograft mouse model of pleomorphic liposarcoma. J Cell Biochem. 2018 09; 119(9):7827-7833. Kiyuna T, Tome Y, Murakami T, Zhao M, Miyake K, Igarashi K, Kawaguchi K, Miyake M, Oshiro H, Higuchi T, Li Y, Dry SM, Nelson SD, Russell TA, Eckardt MA, Singh AS, Kanaya F, Eilber FC, Hoffman RM. PMID: 29932244; PMCID: PMC6150816.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    334. Oral recombinant methioninase (o-rMETase) is superior to injectable rMETase and overcomes acquired gemcitabine resistance in pancreatic cancer. Cancer Lett. 2018 09 28; 432:251-259. Kawaguchi K, Miyake K, Han Q, Li S, Tan Y, Igarashi K, Kiyuna T, Miyake M, Higuchi T, Oshiro H, Zhang Z, Razmjooei S, Wangsiricharoen S, Bouvet M, Singh SR, Unno M, Hoffman RM. PMID: 29928962.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    335. In silico-designed mutations increase variable new-antigen receptor single-domain antibodies for VEGF165 neutralization. Oncotarget. 2018 Jun 15; 9(46):28016-28029. Millán-Gómez D, Dueñas S, Muñoz PLA, Camacho-Villegas T, Elosua C, Cabanillas-Bernal O, Escalante T, Perona A, Abia D, Drescher F, Fournier PGJ, Ramos MA, Mares RE, Paniagua-Solis J, Mata-Gonzalez T, Gonzalez-Canudas J, Hoffman RM, Licea-Navarro A, Sánchez-Campos N. PMID: 29963259; PMCID: PMC6021326.
      View in: PubMed   Mentions: 2     Fields:    
    336. Erratum: Publisher Correction: Is DNA methylation the new guardian of the genome? Mol Cytogenet. 2018; 11:38. Hoffman RM. PMID: 29946362; PMCID: PMC6001167.
      View in: PubMed   Mentions:
    337. Tumor-targeting Salmonella typhimurium A1-R suppressed an imatinib-resistant gastrointestinal stromal tumor with c-kit exon 11 and 17 mutations. Heliyon. 2018 Jun; 4(6):e00643. Miyake K, Kawaguchi K, Miyake M, Zhao M, Kiyuna T, Igarashi K, Zhang Z, Murakami T, Li Y, Nelson SD, Bouvet M, Elliott I, Russell TA, Singh AS, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Singh SR, Endo I, Eilber FC, Hoffman RM. PMID: 30003151; PMCID: PMC6040627.
      View in: PubMed   Mentions: 7  
    338. Moesin Up-regulation Is Associated with Enhanced Tumor Progression Imaged Non-invasively in an Orthotopic Mouse Model of Human Glioblastoma. Anticancer Res. 2018 Jun; 38(6):3267-3272. Wang Q, Lu X, Wang J, Yang Z, Hoffman RM, Wu X. PMID: 29848673.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    339. The development of fluorescence guided surgery for pancreatic cancer: from bench to clinic. Expert Rev Anticancer Ther. 2018 07; 18(7):651-662. Lwin TM, Hoffman RM, Bouvet M. PMID: 29768067; PMCID: PMC6298876.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    340. Doxorubicin-resistant pleomorphic liposarcoma with PDGFRA gene amplification is targeted and regressed by pazopanib in a patient-derived orthotopic xenograft mouse model. Tissue Cell. 2018 Aug; 53:30-36. Kiyuna T, Murakami T, Tome Y, Igarashi K, Kawaguchi K, Miyake K, Miyake M, Li Y, Nelson SD, Dry SM, Singh AS, Russell TA, Singh SR, Kanaya F, Eilber FC, Hoffman RM. PMID: 30060824.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    341. Targeting altered cancer methionine metabolism with recombinant methioninase (rMETase) overcomes partial gemcitabine-resistance and regresses a patient-derived orthotopic xenograft (PDOX) nude mouse model of pancreatic cancer. Cell Cycle. 2018; 17(7):868-873. Kawaguchi K, Miyake K, Han Q, Li S, Tan Y, Igarashi K, Lwin TM, Higuchi T, Kiyuna T, Miyake M, Oshiro H, Bouvet M, Unno M, Hoffman RM. PMID: 29623758; PMCID: PMC6056209.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    342. Temozolomide regresses a doxorubicin-resistant undifferentiated spindle-cell sarcoma patient-derived orthotopic xenograft (PDOX): precision-oncology nude-mouse model matching the patient with effective therapy. J Cell Biochem. 2018 08; 119(8):6598-6603. Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyake M, Li Y, Nelson SD, Dry SM, Singh AS, Elliott IA, Russell TA, Eckardt MA, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 29737543.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCTClinical Trials
    343. MEK inhibitor trametinib in combination with gemcitabine regresses a patient-derived orthotopic xenograft (PDOX) pancreatic cancer nude mouse model. Tissue Cell. 2018 Jun; 52:124-128. Kawaguchi K, Igarashi K, Miyake K, Lwin TM, Miyake M, Kiyuna T, Hwang HK, Murakami T, Delong JC, Singh SR, Clary B, Bouvet M, Unno M, Hoffman RM. PMID: 29857821.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    344. Exploiting methionine restriction for cancer treatment. Biochem Pharmacol. 2018 08; 154:170-173. Chaturvedi S, Hoffman RM, Bertino JR. PMID: 29733806.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    345. Patient-derived orthotopic xenograft models for cancer of unknown primary precisely distinguish chemotherapy, and tumor-targeting S. typhimurium A1-R is superior to first-line chemotherapy. Signal Transduct Target Ther. 2018; 3:12. Miyake K, Kiyuna T, Miyake M, Kawaguchi K, Yoon SN, Zhang Z, Igarashi K, Razmjooei S, Wangsiricharoen S, Murakami T, Li Y, Nelson SD, Russell TA, Singh AS, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Singh SR, Endo I, Eilber FC, Hoffman RM. PMID: 29713497; PMCID: PMC5923205.
      View in: PubMed   Mentions: 4     Fields:    
    346. Recombinant methioninase combined with doxorubicin (DOX) regresses a DOX-resistant synovial sarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model. Oncotarget. 2018 Apr 10; 9(27):19263-19272. Igarashi K, Kawaguchi K, Li S, Han Q, Tan Y, Gainor E, Kiyuna T, Miyake K, Miyake M, Higuchi T, Oshiro H, Singh AS, Eckardt MA, Nelson SD, Russell TA, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 29721200; PMCID: PMC5922394.
      View in: PubMed   Mentions: 9     Fields:    
    347. Tumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: decoy, trap and kill chemotherapy moves toward the clinic. Cell Cycle. 2018; 17(6):801-809. Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyake M, Li S, Han Q, Tan Y, Zhao M, Li Y, Nelson SD, Dry SM, Singh AS, Elliott IA, Russell TA, Eckardt MA, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 29374999; PMCID: PMC5969544.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    348. Ethanolic Extract of Traditional Chinese Medicine (TCM) Gamboge Inhibits Colon Cancer via the Wnt/Beta-Catenin Signaling Pathway in an Orthotopic Mouse Model. Anticancer Res. 2018 04; 38(4):1917-1925. Wang W, Li Y, Chen Y, Chen H, Zhu P, Xu M, Wang H, Wu M, Yang Z, Hoffman RM, Gu Y. PMID: 29599307.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    349. Differential Organ-targeting and Cellular Characteristics of Metastatic Human Pancreatic Cancer Cell Lines in Mouse Models. Anticancer Res. 2018 04; 38(4):1927-1935. Satake T, Suetsugu A, Nakamura M, Hasegawa K, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. PMID: 29599308.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    350. Visualizing the Tumor Microenvironment by Color-coded Imaging in Orthotopic Mouse Models of Cancer. Anticancer Res. 2018 04; 38(4):1847-1857. Suetsugu A, Shimizu M, Saji S, Moriwaki H, Hoffman RM. PMID: 29599301.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    351. Individualized doxorubicin sensitivity testing of undifferentiated soft tissue sarcoma (USTS) in a patient-derived orthotopic xenograft (PDOX) model demonstrates large differences between patients. Cell Cycle. 2018; 17(5):627-633. Kawaguchi K, Igarashi K, Kiyuna T, Miyake K, Miyake M, Murakami T, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Singh AS, Unno M, Eilber FC, Hoffman RM. PMID: 29384032; PMCID: PMC5969558.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    352. Targeting methionine with oral recombinant methioninase (o-rMETase) arrests a patient-derived orthotopic xenograft (PDOX) model of BRAF-V600E mutant melanoma: implications for chronic clinical cancer therapy and prevention. Cell Cycle. 2018; 17(3):356-361. Kawaguchi K, Han Q, Li S, Tan Y, Igarashi K, Kiyuna T, Miyake K, Miyake M, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Singh AS, Eckardt MA, Unno M, Eilber FC, Hoffman RM. PMID: 29187018; PMCID: PMC5914727.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    353. Tumor-targeting Salmonella typhimurium A1-R is a highly effective general therapeutic for undifferentiated soft tissue sarcoma patient-derived orthotopic xenograft nude-mouse models. Biochem Biophys Res Commun. 2018 03 18; 497(4):1055-1061. Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyake M, Singh AS, Eckardt MA, Nelson SD, Russell TA, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Singh SR, Eilber FC, Hoffman RM. PMID: 29481803.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    354. RT-PCR of peritoneal washings predicts peritoneal pancreatic cancer recurrence. J Surg Res. 2018 06; 226:122-130. Sato K, Mori R, Hiroshima Y, Oba MS, Matsuyama R, Bouvet M, Hoffman RM, Endo I. PMID: 29661277.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    355. Inhibition of growth and metastasis of triple-negative breast cancer targeted by Traditional Chinese Medicine Tubeimu in orthotopic mice models. Chin J Cancer Res. 2018 Feb; 30(1):112-121. Wang J, Yang X, Han H, Wang L, Bao W, Wang S, Hoffman RM, Yang M, Qi H, An C, Hu K. PMID: 29545725; PMCID: PMC5842225.
      View in: PubMed   Mentions: 7  
    356. Fluorescence-guided Surgery with Splenic Preservation Prevents Tumor Recurrence in an Orthotopic Nude-mouse Model of Human Pancreatic Cancer. Anticancer Res. 2018 02; 38(2):665-670. Hwang HK, Kang CM, Lee SH, Murakami T, Kiyuna T, Kim SH, Hoffman RM, Bouvet M. PMID: 29374688.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    357. Tumor-Specific Labeling of Pancreatic Cancer Using a Humanized Anti-CEA Antibody Conjugated to a Near-Infrared Fluorophore. Ann Surg Oncol. 2018 Apr; 25(4):1079-1085. Lwin TM, Murakami T, Miyake K, Yazaki PJ, Shivley JE, Hoffman RM, Bouvet M. PMID: 29372363; PMCID: PMC5842124.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    358. Bacterial Therapy of Cancer: Promises, Limitations, and Insights for Future Directions. Front Microbiol. 2018; 9:16. Kramer MG, Masner M, Ferreira FA, Hoffman RM. PMID: 29472896; PMCID: PMC5810261.
      View in: PubMed   Mentions: 52  
    359. Intra-tumor L-methionine level highly correlates with tumor size in both pancreatic cancer and melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse models. Oncotarget. 2018 Feb 16; 9(13):11119-11125. Kawaguchi K, Han Q, Li S, Tan Y, Igarashi K, Miyake K, Kiyuna T, Miyake M, Chemielwski B, Nelson SD, Russell TA, Dry SM, Li Y, Singh AS, Eckardt MA, Unno M, Eilber FC, Hoffman RM. PMID: 29541401; PMCID: PMC5834286.
      View in: PubMed   Mentions: 16     Fields:    
    360. Engineered mesenchymal stem-cell-sheets patches prevents postoperative pancreatic leakage in a rat model. Sci Rep. 2018 01 10; 8(1):360. Kim SR, Yi HJ, Lee YN, Park JY, Hoffman RM, Okano T, Shim IK, Kim SC. PMID: 29321630; PMCID: PMC5762914.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    361. Recombinant methioninase in combination with doxorubicin (DOX) overcomes first-line DOX resistance in a patient-derived orthotopic xenograft nude-mouse model of undifferentiated spindle-cell sarcoma. Cancer Lett. 2018 03 28; 417:168-173. Igarashi K, Kawaguchi K, Li S, Han Q, Tan Y, Murakami T, Kiyuna T, Miyake K, Miyake M, Singh AS, Eckardt MA, Nelson SD, Russell TA, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Singh SR, Eilber FC, Hoffman RM. PMID: 29306021.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    362. Growth of doxorubicin-resistant undifferentiated spindle-cell sarcoma PDOX is arrested by metabolic targeting with recombinant methioninase. J Cell Biochem. 2018 04; 119(4):3537-3544. Igarashi K, Li S, Han Q, Tan Y, Kawaguchi K, Murakami T, Kiyuna T, Miyake K, Li Y, Nelson SD, Dry SM, Singh AS, Elliott IA, Russell TA, Eckardt MA, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 29143983.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    363. Traditional Chinese Medicine Curcumin Sensitizes Human Colon Cancer to Radiation by Altering the Expression of DNA Repair-related Genes. Anticancer Res. 2018 01; 38(1):131-136. Yang G, Qiu J, Wang D, Tao Y, Song Y, Wang H, Tang J, Wang X, Sun YU, Yang Z, Hoffman RM. PMID: 29277765.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    364. Tumor-targeting Salmonella typhimurium A1-R Inhibits Osteosarcoma Angiogenesis in the In Vivo Gelfoam® Assay Visualized by Color-coded Imaging. Anticancer Res. 2018 01; 38(1):159-164. Kiyuna T, Tome Y, Uehara F, Murakami T, Zhang Y, Zhao M, Kanaya F, Hoffman RM. PMID: 29277768.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    365. In Vivo-Like Growth Patterns of Multiple Types of Tumors in Gelfoam® Histoculture. Methods Mol Biol. 2018; 1760:19-28. Hoffman RM, Freeman AE. PMID: 29572790.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    366. Expression and Targeting of Tumor Markers in Gelfoam® Histoculture: Potential Individualized Assays for Immuno-Oncology. Methods Mol Biol. 2018; 1760:29-37. Hoffman RM, Guadagni F. PMID: 29572791.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    367. Development of the Histoculture Drug Response Assay (HDRA). Methods Mol Biol. 2018; 1760:39-48. Hoffman RM, Vescio RA. PMID: 29572792.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    368. Diagnosis and Pathological Analysis of Patient Cancers by Detection of Proliferating Cells in Gelfoam® Histoculture. Methods Mol Biol. 2018; 1760:49-60. Hoffman RM. PMID: 29572793.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    369. Prospective Clinical Correlation of the Histoculture Drug Response Assay for Ovarian Cancer. Methods Mol Biol. 2018; 1760:73-81. Hoffman RM, Jung PS, Kim MB, Nam JH. PMID: 29572795.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    370. Clinical Usefulness of the Histoculture Drug Response Assay for Breast Cancer. Methods Mol Biol. 2018; 1760:93-100. Hoffman RM, Tanino H. PMID: 29572797.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    371. Comparison of "Dimensionality" of Cancer Cell Culture in Gelfoam® Histoculture and Matrigel. Methods Mol Biol. 2018; 1760:205-214. Tome Y, Uehara F, Kanaya F, Hoffman RM. PMID: 29572806.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    372. Imaging the Governing Step of Metastasis in Gelfoam® Histoculture. Methods Mol Biol. 2018; 1760:215-220. Hoffman RM, Chishima T. PMID: 29572807.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    373. Effects of siRNA Silencing of TUG1 and LCAL6 Long Non-coding RNAs on Patient-derived Xenograft of Non-small Cell Lung Cancer. Anticancer Res. 2018 01; 38(1):179-186. Fang T, Huang H, Li X, Liao J, Yang Z, Hoffman RM, Cheng XI, Liang L, Hu W, Yun S. PMID: 29277771.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    374. 3D Sponge-Matrix Histoculture: An Overview. Methods Mol Biol. 2018; 1760:11-17. Hoffman RM. PMID: 29572789.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    375. Clinical Correlation of the Histoculture Drug Response Assay for Head and Neck Cancer. Methods Mol Biol. 2018; 1760:83-92. Hoffman RM. PMID: 29572796.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    376. Nerve Growth and Interaction in Gelfoam® Histoculture: A Nervous System Organoid. Methods Mol Biol. 2018; 1760:163-186. Hoffman RM, Mii S, Duong J, Amoh Y. PMID: 29572803.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    377. Imaging DNA Repair After UV Irradiation Damage of Cancer Cells in Gelfoam® Histoculture. Methods Mol Biol. 2018; 1760:199-203. Miwa S, Hoffman RM. PMID: 29572805.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    378. Clinical Usefulness of the Histoculture Drug Response Assay for Prostate Cancer and Benign Prostate Hypertrophy (BPH). Methods Mol Biol. 2018; 1760:101-107. Hoffman RM. PMID: 29572798.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    379. In Vivo-Like Cell-Cycle Phase Distribution of Cancer Cells in Gelfoam® Histoculture Observed in Real Time by FUCCI Imaging. Methods Mol Biol. 2018; 1760:109-123. Hoffman RM, Yano S. PMID: 29572799.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    380. Methionine Dependency Determination of Human Patient Tumors in Gelfoam® Histoculture. Methods Mol Biol. 2018; 1760:125-131. Hoffman RM. PMID: 29572800.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    381. Hair-Shaft Growth in Gelfoam® Histoculture of Skin and Isolated Hair Follicles. Methods Mol Biol. 2018; 1760:133-144. Hoffman RM, Li L, Cao W. PMID: 29572801.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    382. Hair Follicle-Associated Pluripotent (HAP) Stem Cells in Gelfoam® Histoculture for Use in Spinal Cord Repair. Methods Mol Biol. 2018; 1760:145-162. Liu F, Hoffman RM. PMID: 29572802.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    383. Regorafenib regresses an imatinib-resistant recurrent gastrointestinal stromal tumor (GIST) with a mutation in exons 11 and 17 of c-kit in a patient-derived orthotopic xenograft (PDOX) nude mouse model. Cell Cycle. 2018; 17(6):722-727. Miyake K, Kawaguchi K, Kiyuna T, Miyake M, Igarashi K, Zhang Z, Murakami T, Li Y, Nelson SD, Elliott I, Russell T, Singh A, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Endo I, Eilber FC, Hoffman RM. PMID: 29334307; PMCID: PMC5969563.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    384. Clinical Correlation of the Histoculture Drug Response Assay in Gastrointestinal Cancer. Methods Mol Biol. 2018; 1760:61-72. Hoffman RM. PMID: 29572794.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    385. Beating Heart Cells from Hair-Follicle-Associated Pluripotent (HAP) Stem Cells. Methods Mol Biol. 2018; 1842:241-254. Hoffman RM, Amoh Y. PMID: 30196415.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    386. Genetic and metabolic comparison of orthotopic and heterotopic patient-derived pancreatic-cancer xenografts to the original patient tumors. Oncotarget. 2018 Jan 30; 9(8):7867-7881. Jun E, Hong SM, Yoo HJ, Kim MB, Won JS, An S, Shim IK, Chang S, Hoffman RM, Kim SC. PMID: 29487698; PMCID: PMC5814265.
      View in: PubMed   Mentions: 7     Fields:    
    387. Recombinant methioninase (rMETase) is an effective therapeutic for BRAF-V600E-negative as well as -positive melanoma in patient-derived orthotopic xenograft (PDOX) mouse models. Oncotarget. 2018 Jan 02; 9(1):915-923. Kawaguchi K, Igarashi K, Li S, Han Q, Tan Y, Miyake K, Kiyuna T, Miyake M, Murakami T, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Unno M, Eilber FC, Hoffman RM. PMID: 29416666; PMCID: PMC5787523.
      View in: PubMed   Mentions: 19     Fields:    
    388. Temozolomide combined with irinotecan regresses a cisplatinum-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) precision-oncology mouse model. Oncotarget. 2018 Jan 30; 9(8):7774-7781. Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyake M, Li Y, Nelson SD, Dry SM, Singh AS, Elliott IA, Russell TA, Eckardt MA, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 29487690; PMCID: PMC5814257.
      View in: PubMed   Mentions: 6     Fields:    
    389. Near-infrared-conjugated humanized anti-carcinoembryonic antigen antibody targets colon cancer in an orthotopic nude-mouse model. J Surg Res. 2017 10; 218:139-143. DeLong JC, Murakami T, Yazaki PJ, Hoffman RM, Bouvet M. PMID: 28985840; PMCID: PMC5650098.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    390. Splenectomy is associated with an aggressive tumor growth pattern and altered host immunity in an orthotopic syngeneic murine pancreatic cancer model. Oncotarget. 2017 Oct 24; 8(51):88827-88834. Hwang HK, Murakami T, Kiyuna T, Kim SH, Lee SH, Kang CM, Hoffman RM, Bouvet M. PMID: 29179479; PMCID: PMC5687649.
      View in: PubMed   Mentions: 6     Fields:    
    391. Regarding the applications of fusion-fluorescence imaging using indocyanine green in laparoscopic hepatectomy. Transl Gastroenterol Hepatol. 2017; 2:70. Lwin TM, Hoffman RM, Bouvet M. PMID: 29034343; PMCID: PMC5638993.
      View in: PubMed   Mentions: 3  
    392. Eribulin regresses a doxorubicin-resistant Ewing's sarcoma with a FUS-ERG fusion and CDKN2A-deletion in a patient-derived orthotopic xenograft (PDOX) nude mouse model. J Cell Biochem. 2018 01; 119(1):967-972. Miyake K, Murakami T, Kiyuna T, Igarashi K, Kawaguchi K, Li Y, Singh AS, Dry SM, Eckardt MA, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Endo I, Eilber FC, Hoffman RM. PMID: 28681998.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    393. The combination of temozolomide-irinotecan regresses a doxorubicin-resistant patient-derived orthotopic xenograft (PDOX) nude-mouse model of recurrent Ewing's sarcoma with a FUS-ERG fusion and CDKN2A deletion: Direction for third-line patient therapy. Oncotarget. 2017 Nov 28; 8(61):103129-103136. Miyake K, Murakami T, Kiyuna T, Igarashi K, Kawaguchi K, Miyake M, Li Y, Nelson SD, Dry SM, Bouvet M, Elliott IA, Russell TA, Singh AS, Eckardt MA, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Endo I, Eilber FC, Hoffman RM. PMID: 29262551; PMCID: PMC5732717.
      View in: PubMed   Mentions: 19     Fields:    
    394. Implanted hair-follicle-associated pluripotent (HAP) stem cells encapsulated in polyvinylidene fluoride membrane cylinders promote effective recovery of peripheral nerve injury. Cell Cycle. 2017 Oct 18; 16(20):1927-1932. Yamazaki A, Obara K, Tohgi N, Shirai K, Mii S, Hamada Y, Arakawa N, Aki R, Hoffman RM, Amoh Y. PMID: 28886268; PMCID: PMC5638363.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    395. Hair follicle-associated-pluripotent (HAP) stem cells. Cell Cycle. 2017; 16(22):2169-2175. Amoh Y, Hoffman RM. PMID: 28749199; PMCID: PMC5736337.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    396. Effective Metabolic Targeting of Human Osteosarcoma Cells In Vitro and in Orthotopic Nude-mouse Models with Recombinant Methioninase. Anticancer Res. 2017 09; 37(9):4807-4812. Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Murakami T, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Hoffman RM. PMID: 28870899.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    397. Patient-Derived Orthotopic Xenograft (PDOX) Models of Melanoma. Int J Mol Sci. 2017 Aug 31; 18(9). Hoffman RM. PMID: 28858204; PMCID: PMC5618524.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    398. Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model. Oncotarget. 2017 Oct 17; 8(49):85516-85525. Kawaguchi K, Igarashi K, Li S, Han Q, Tan Y, Kiyuna T, Miyake K, Murakami T, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Unno M, Eilber FC, Hoffman RM. PMID: 29156737; PMCID: PMC5689627.
      View in: PubMed   Mentions: 32     Fields:    
    399. Tumor-Targeting Salmonella typhimurium A1-R Promotes Tumoricidal CD8+ T Cell Tumor Infiltration and Arrests Growth and Metastasis in a Syngeneic Pancreatic-Cancer Orthotopic Mouse Model. J Cell Biochem. 2018 01; 119(1):634-639. Murakami T, Hiroshima Y, Zhang Y, Zhao M, Kiyuna T, Hwang HK, Miyake K, Homma Y, Mori R, Matsuyama R, Chishima T, Ichikawa Y, Tanaka K, Bouvet M, Endo I, Hoffman RM. PMID: 28628234.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    400. Clinical Factors That Affect the Establishment of Soft Tissue Sarcoma Patient-Derived Orthotopic Xenografts: A University of California, Los Angeles, Sarcoma Program Prospective Clinical Trial. JCO Precis Oncol. 2017; 2017. Russell TA, Eckardt MA, Murakami T, Elliott IA, Kawaguchi K, Kiyuna T, Igarashi K, Li Y, Crompton JG, Graham DS, Dry SM, Bernthal N, Yanagawa J, Kalbasi A, Federman N, Chmielowski B, Singh AS, Hoffman RM, Eilber FC. PMID: 30613825; PMCID: PMC6319895.
      View in: PubMed   Mentions: 3     Fields:    
    401. Chemoprevention by Quercetin of Oral Squamous Cell Carcinoma by Suppression of the NF-κB Signaling Pathway in DMBA-treated Hamsters. Anticancer Res. 2017 08; 37(8):4041-4049. Zhang W, Yin G, Dai J, Sun YU, Hoffman RM, Yang Z, Fan Y. PMID: 28739686.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    402. Efficacy In Vitro of Caffeine and Valproic Acid on Patient-Derived Undifferentiated Pleomorphic Sarcoma and Rhabdomyosarcoma Cell Lines. Anticancer Res. 2017 08; 37(8):4081-4084. Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Miwa S, Nelson SD, Dry SM, Li Y, Singh AS, Kimura H, Hayashi K, Yamamoto N, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 28739691.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    403. Therapeutic Cell-Cycle-Decoy Efficacy of a Telomerase-Dependent Adenovirus in an Orthotopic Model of Chemotherapy-Resistant Human Stomach Carcinomatosis Peritonitis Visualized With FUCCI Imaging. J Cell Biochem. 2017 11; 118(11):3635-3642. Yano S, Takehara K, Tazawa H, Kishimoto H, Urata Y, Kagawa S, Fujiwara T, Hoffman RM. PMID: 27171483.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    404. MEK inhibitors cobimetinib and trametinib, regressed a gemcitabine-resistant pancreatic-cancer patient-derived orthotopic xenograft (PDOX). Oncotarget. 2017 Jul 18; 8(29):47490-47496. Kawaguchi K, Igarashi K, Murakami T, Kiyuna T, Lwin TM, Hwang HK, Delong JC, Clary BM, Bouvet M, Unno M, Hoffman RM. PMID: 28537897; PMCID: PMC5564580.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    405. A patient-derived orthotopic xenograft (PDOX) mouse model of a cisplatinum-resistant osteosarcoma lung metastasis that was sensitive to temozolomide and trabectedin: implications for precision oncology. Oncotarget. 2017 Sep 22; 8(37):62111-62119. Igarashi K, Murakami T, Kawaguchi K, Kiyuna T, Miyake K, Zhang Y, Nelson SD, Dry SM, Li Y, Yanagawa J, Russell TA, Singh AS, Tsuchiya H, Elliott I, Eilber FC, Hoffman RM. PMID: 28977930; PMCID: PMC5617490.
      View in: PubMed   Mentions: 23     Fields:    
    406. Enhancement of Wound Healing by the Traditional Chinese Medicine Herbal Mixture Sophora flavescens in a Rat Model of Perianal Ulceration. In Vivo. 2017 Jul-Aug; 31(4):543-549. Xu X, Li X, Zhang L, Liu Z, Pan Y, Chen D, Bin D, Deng Q, Sun YU, Hoffman RM, Yang Z, Yuan H. PMID: 28652418; PMCID: PMC5566901.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    407. Choline-Deficient-Diet-Induced Fatty Liver Is a Metastasis-Resistant Microenvironment. Anticancer Res. 2017 07; 37(7):3429-3434. Nakamura M, Suetsugu A, Hasegawa K, Matsumoto T, Aoki H, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. PMID: 28668831.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    408. Imaging the Role of Multinucleate Pancreatic Cancer Cells and Cancer-Associated Fibroblasts in Peritoneal Metastasis in Mouse Models. Anticancer Res. 2017 07; 37(7):3435-3440. Hasegawa K, Suetsugu A, Nakamura M, Matsumoto T, Aoki H, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. PMID: 28668832.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    409. On the role of classical and novel forms of vitamin D in melanoma progression and management. J Steroid Biochem Mol Biol. 2018 03; 177:159-170. Slominski AT, Brozyna AA, Skobowiat C, Zmijewski MA, Kim TK, Janjetovic Z, Oak AS, Jozwicki W, Jetten AM, Mason RS, Elmets C, Li W, Hoffman RM, Tuckey RC. PMID: 28676457; PMCID: PMC5748362.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimals
    410. A novel anionic-phosphate-platinum complex effectively targets an undifferentiated pleomorphic sarcoma better than cisplatinum and doxorubicin in a patient-derived orthotopic xenograft (PDOX). Oncotarget. 2017 Sep 08; 8(38):63353-63359. Igarashi K, Kawaguchi K, Murakami T, Kiyuna T, Miyake K, Yamamoto N, Hayashi K, Kimura H, Nelson SD, Dry SM, Li Y, Singh AS, Miwa S, Odani A, Eilber FC, Tsuchiya H, Hoffman RM. PMID: 28968995; PMCID: PMC5609927.
      View in: PubMed   Mentions: 11     Fields:    
    411. Pancreatic cancer-derived exosomes promote tumor metastasis and liver pre-metastatic niche formation. Oncotarget. 2017 Sep 08; 8(38):63461-63483. Yu Z, Zhao S, Ren L, Wang L, Chen Z, Hoffman RM, Zhou J. PMID: 28969005; PMCID: PMC5609937.
      View in: PubMed   Mentions: 57     Fields:    
    412. Locally-applied 5-fluorouracil-loaded slow-release patch prevents pancreatic cancer growth in an orthotopic mouse model. Oncotarget. 2017 Jun 20; 8(25):40140-40151. Shim IK, Yi HJ, Yi HG, Lee CM, Lee YN, Choi YJ, Jeong SY, Jun E, Hoffman RM, Cho DW, Kim SC. PMID: 28498800; PMCID: PMC5522260.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    413. Salmonella typhimurium A1-R targeting of a chemotherapy-resistant BRAF-V600E melanoma in a patient-derived orthotopic xenograft (PDOX) model is enhanced in combination with either vemurafenib or temozolomide. Cell Cycle. 2017 Jul 03; 16(13):1288-1294. Kawaguchi K, Igarashi K, Murakami T, Kiyuna T, Zhao M, Zhang Y, Nelson SD, Russell TA, Dry SM, Singh AS, Chmielowski B, Li Y, Unno M, Eilber FC, Hoffman RM. PMID: 28622068; PMCID: PMC5531627.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    414. Neoadjuvant chemoradiotherapy of pancreatic cancer induces a favorable immunogenic tumor microenvironment associated with increased major histocompatibility complex class I-related chain A/B expression. J Surg Oncol. 2017 Sep; 116(3):416-426. Murakami T, Homma Y, Matsuyama R, Mori R, Miyake K, Tanaka Y, Den K, Nagashima Y, Nakazawa M, Hiroshima Y, Ueda M, Tanaka K, Hoffman RM, Bouvet M, Endo I. PMID: 28608409.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    415. Genetic Recombination Between Stromal and Cancer Cells Results in Highly Malignant Cells Identified by Color-Coded Imaging in a Mouse Lymphoma Model. J Cell Biochem. 2017 12; 118(12):4216-4221. Nakamura M, Suetsugu A, Hasegawa K, Matsumoto T, Aoki H, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. PMID: 28419513.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    416. Recombinant methioninase effectively targets a Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model. Oncotarget. 2017 May 30; 8(22):35630-35638. Murakami T, Li S, Han Q, Tan Y, Kiyuna T, Igarashi K, Kawaguchi K, Hwang HK, Miyake K, Singh AS, Nelson SD, Dry SM, Li Y, Hiroshima Y, Lwin TM, DeLong JC, Chishima T, Tanaka K, Bouvet M, Endo I, Eilber FC, Hoffman RM. PMID: 28404944; PMCID: PMC5482604.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimals
    417. Strategies for In Vivo Imaging Using Fluorescent Proteins. J Cell Biochem. 2017 09; 118(9):2571-2580. Hoffman RM. PMID: 27564860.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    418. Analysis of Stroma Labeling During Multiple Passage of a Sarcoma Imageable Patient-Derived Orthotopic Xenograft (iPDOX) in Red Fluorescent Protein Transgenic Nude Mice. J Cell Biochem. 2017 10; 118(10):3367-3371. Kiyuna T, Murakami T, Tome Y, Kawaguchi K, Igarashi K, Miyake K, Kanaya F, Singh A, Eilber FC, Hoffman RM. PMID: 28300287; PMCID: PMC5550328.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    419. Intra-arterial administration of tumor-targeting Salmonella typhimurium A1-R regresses a cisplatin-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model. Cell Cycle. 2017 Jun 18; 16(12):1164-1170. Igarashi K, Kawaguchi K, Murakami T, Kiyuna T, Miyake K, Nelson SD, Dry SM, Li Y, Yanagawa J, Russell TA, Singh AS, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 28494180; PMCID: PMC5499917.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    420. Toxicology and efficacy of tumor-targeting Salmonella typhimurium A1-R compared to VNP 20009 in a syngeneic mouse tumor model in immunocompetent mice. Oncotarget. 2017 Aug 15; 8(33):54616-54628. Zhang Y, Cao W, Toneri M, Zhang N, Kiyuna T, Murakami T, Nelson SD, Dry SM, Li Y, Li S, Wang X, Ma H, Singh AS, Eilber FC, Hoffman RM, Zhao M. PMID: 28903369; PMCID: PMC5589608.
      View in: PubMed   Mentions: 12     Fields:    
    421. Moesin Expression Is Associated with Glioblastoma Cell Proliferation and Invasion. Anticancer Res. 2017 05; 37(5):2211-2218. Wang Q, Lu X, Zhao S, Pang M, Wu X, Wu H, Hoffman RM, Yang Z, Zhang Y. PMID: 28476784.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    422. High Efficacy of Pazopanib on an Undifferentiated Spindle-Cell Sarcoma Resistant to First-Line Therapy Is Identified With a Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model. J Cell Biochem. 2017 09; 118(9):2739-2743. Igarashi K, Kawaguchi K, Murakami T, Kiyuna T, Miyake K, Singh AS, Nelson SD, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 28176365.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    423. Color-coded intravital imaging demonstrates a transforming growth factor-β (TGF-β) antagonist selectively targets stromal cells in a human pancreatic-cancer orthotopic mouse model. Cell Cycle. 2017 May 19; 16(10):1008-1014. Murakami T, Hiroshima Y, Miyake K, Hwang HK, Kiyuna T, DeLong JC, Lwin TM, Matsuyama R, Mori R, Kumamoto T, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM. PMID: 28441080; PMCID: PMC5462077.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    424. Tumor-Targeting Salmonella typhimurium A1-R Sensitizes Melanoma With a BRAF-V600E Mutation to Vemurafenib in a Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model. J Cell Biochem. 2017 08; 118(8):2314-2319. Kawaguchi K, Igarashi K, Murakami T, Zhao M, Zhang Y, Chmielowski B, Kiyuna T, Nelson SD, Russell TA, Dry SM, Li Y, Unno M, Eilber FC, Hoffman RM. PMID: 28106277.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    425. Combination of gemcitabine and docetaxel regresses both gastric leiomyosarcoma proliferation and invasion in an imageable patient-derived orthotopic xenograft (iPDOX) model. Cell Cycle. 2017 Jun 03; 16(11):1063-1069. Kawaguchi K, Igarashi K, Murakami T, Kiyuna T, Nelson SD, Dry SM, Li Y, Russell TA, Singh AS, Chmielowski B, Unno M, Eilber FC, Hoffman RM. PMID: 28426279; PMCID: PMC5499841.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    426. Is DNA methylation the new guardian of the genome? Mol Cytogenet. 2017; 10:11. Hoffman RM. PMID: 28396696; PMCID: PMC5381125.
      View in: PubMed   Mentions: 14  
    427. Temozolomide combined with irinotecan caused regression in an adult pleomorphic rhabdomyosarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model. Oncotarget. 2017 Sep 29; 8(44):75874-75880. Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Miwa S, Nelson SD, Dry SM, Li Y, Singh AS, Kimura H, Hayashi K, Yamamoto N, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 29100276; PMCID: PMC5652670.
      View in: PubMed   Mentions: 18     Fields:    
    428. High-efficacy targeting of colon-cancer liver metastasis with Salmonella typhimurium A1-R via intra-portal-vein injection in orthotopic nude-mouse models. Oncotarget. 2017 Mar 21; 8(12):19065-19073. Kawaguchi K, Murakami T, Suetsugu A, Kiyuna T, Igarashi K, Hiroshima Y, Zhao M, Zhang Y, Bouvet M, Clary BM, Unno M, Hoffman RM. PMID: 27683127; PMCID: PMC5386670.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    429. The wayward methyl group and the cascade to cancer. Cell Cycle. 2017 May 03; 16(9):825-829. Hoffman RM. PMID: 28318368; PMCID: PMC5444351.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    430. The irony of highly-effective bacterial therapy of a patient-derived orthotopic xenograft (PDOX) model of Ewing's sarcoma, which was blocked by Ewing himself 80 years ago. Cell Cycle. 2017 Jun 03; 16(11):1046-1052. Murakami T, Kiyuna T, Kawaguchi K, Igarashi K, Singh AS, Hiroshima Y, Zhang Y, Zhao M, Miyake K, Nelson SD, Dry SM, Li Y, DeLong JC, Lwin TM, Chishima T, Tanaka K, Bouvet M, Endo I, Eilber FC, Hoffman RM. PMID: 28296559; PMCID: PMC5499836.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    431. Anti-metastatic Efficacy of Traditional Chinese Medicine (TCM) Ginsenoside Conjugated to a VEFGR-3 Antibody on Human Gastric Cancer in an Orthotopic Mouse Model. Anticancer Res. 2017 03; 37(3):979-986. Dai X, Liu D, Liu M, Zhang X, Wang W, Jin F, Qian Y, Wang X, Zhao J, Wu Y, Xiong F, Chang NA, Sun YU, Yang Z, Hoffman RM, Liu Y. PMID: 28314255.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    432. Antimetastatic Efficacy of the Combination of Caffeine and Valproic Acid on an Orthotopic Human Osteosarcoma Cell Line Model in Nude Mice. Anticancer Res. 2017 03; 37(3):1005-1011. Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Hoffman RM. PMID: 28314258.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    433. Potential of immunotherapy for sarcoma. Cancer. 2017 05 01; 123(9):1488-1489. Hoffman RM, Singh AS, Eilber FC. PMID: 28241102.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    434. GFP labeling kinetics of triple-negative human breast cancer by a killer-reporter adenovirus in 3D Gelfoam® histoculture. In Vitro Cell Dev Biol Anim. 2017 Jun; 53(6):479-482. Yano S, Takehara K, Miwa S, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 28233141.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    435. Synergistic Inhibitory Effect of Traditional Chinese Medicine Astragaloside IV and Curcumin on Tumor Growth and Angiogenesis in an Orthotopic Nude-Mouse Model of Human Hepatocellular Carcinoma. Anticancer Res. 2017 02; 37(2):465-473. Zhang S, Tang D, Zang W, Yin G, Dai J, Sun YU, Yang Z, Hoffman RM, Guo X. PMID: 28179291.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    436. Tumor-targeting Salmonella typhimurium A1-R regresses an osteosarcoma in a patient-derived xenograft model resistant to a molecular-targeting drug. Oncotarget. 2017 Jan 31; 8(5):8035-8042. Murakami T, Igarashi K, Kawaguchi K, Kiyuna T, Zhang Y, Zhao M, Hiroshima Y, Nelson SD, Dry SM, Li Y, Yanagawa J, Russell T, Federman N, Singh A, Elliott I, Matsuyama R, Chishima T, Tanaka K, Endo I, Eilber FC, Hoffman RM. PMID: 28030831; PMCID: PMC5352380.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    437. High-metastatic triple-negative breast-cancer variants selected in vivo become chemoresistant in vitro. In Vitro Cell Dev Biol Anim. 2017 Apr; 53(4):285-287. Yano S, Takehara K, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 28127701.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    438. A novel method for RNA extraction from FFPE samples reveals significant differences in biomarker expression between orthotopic and subcutaneous pancreatic cancer patient-derived xenografts. Oncotarget. 2017 Jan 24; 8(4):5885-5894. Hoover M, Adamian Y, Brown M, Maawy A, Chang A, Lee J, Gharibi A, Katz MH, Fleming J, Hoffman RM, Bouvet M, Doebler R, Kelber JA. PMID: 27602776; PMCID: PMC5351598.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    439. Reconstitution of a metastatic-resistant tumor microenvironment with cancer-associated fibroblasts enables metastasis. Cell Cycle. 2017 Mar 19; 16(6):533-535. Murata T, Mekada E, Hoffman RM. PMID: 28103135; PMCID: PMC5384587.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    440. Eradication of melanoma in vitro and in vivo via targeting with a Killer-Red-containing telomerase-dependent adenovirus. Cell Cycle. 2017 Aug 18; 16(16):1502-1508. Takehara K, Yano S, Tazawa H, Kishimoto H, Narii N, Mizuguchi H, Urata Y, Kagawa S, Fujiwara T, Hoffman RM. PMID: 28055296; PMCID: PMC5584861.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    441. Comparison of Tumor Recurrence After Resection of Highly- and Poorly-Metastatic Triple-negative Breast Cancer in Orthotopic Nude-Mouse Models. Anticancer Res. 2017 01; 37(1):57-60. Yano S, Takehara K, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Fujiwara T, Bouvet M, Hoffman RM. PMID: 28011473.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    442. Cervical Cancer Patient-Derived Orthotopic Xenograft (PDOX) Is Sensitive to Cisplatinum and Resistant to Nab-paclitaxel. Anticancer Res. 2017 01; 37(1):61-65. Murakami T, Murata T, Kawaguchi K, Kiyuna T, Igarashi K, Hwang HK, Hiroshima Y, Hozumi C, Komatsu S, Kikuchi T, Lwin TM, Delong JC, Miyake K, Zhang Y, Tanaka K, Bouvet M, Endo I, Hoffman RM. PMID: 28011474; PMCID: PMC5831332.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    443. The disintegrin echistatin in combination with doxorubicin targets high-metastatic human osteosarcoma overexpressing ανβ3 integrin in chick embryo and nude mouse models. Oncotarget. 2016 Dec 27; 7(52):87031-87036. Tome Y, Kimura H, Sugimoto N, Tsuchiya H, Kanaya F, Bouvet M, Hoffman RM. PMID: 27894082; PMCID: PMC5349968.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    444. Tumor-targeting Salmonella typhimurium A1-R combined with temozolomide regresses malignant melanoma with a BRAF-V600E mutation in a patient-derived orthotopic xenograft (PDOX) model. Oncotarget. 2016 Dec 27; 7(52):85929-85936. Kawaguchi K, Igarashi K, Murakami T, Chmielowski B, Kiyuna T, Zhao M, Zhang Y, Singh A, Unno M, Nelson SD, Russell TA, Dry SM, Li Y, Eilber FC, Hoffman RM. PMID: 27835903; PMCID: PMC5349886.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    445. Tumor-targeting adenovirus OBP-401 inhibits primary and metastatic tumor growth of triple-negative breast cancer in orthotopic nude-mouse models. Oncotarget. 2016 Dec 20; 7(51):85273-85282. Yano S, Takehara K, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 27863373; PMCID: PMC5356735.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    446. BRCAness and Prognosis in Triple-Negative Breast Cancer Patients Treated with Neoadjuvant Chemotherapy. PLoS One. 2016; 11(12):e0165721. Tanino H, Kosaka Y, Nishimiya H, Tanaka Y, Minatani N, Kikuchi M, Shida A, Waraya M, Katoh H, Enomoto T, Sengoku N, Kajita S, Hoffman RM, Watanabe M. PMID: 27935989; PMCID: PMC5147808.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    447. In Vivo Selection of Intermediately- and Highly-Malignant Variants of Triple-negative Breast Cancer in Orthotopic Nude Mouse Models. Anticancer Res. 2016 12; 36(12):6273-6277. Yano S, Takehara K, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 27919946.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    448. Human hair-follicle associated pluripotent (hHAP) stem cells differentiate to cardiac-muscle cells. Cell Cycle. 2017 Jan 02; 16(1):95-99. Tohgi N, Obara K, Yashiro M, Hamada Y, Arakawa N, Mii S, Aki R, Hoffman RM, Amoh Y. PMID: 27880068; PMCID: PMC5270544.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    449. Efficacy of glycogen synthase kinase-3β targeting against osteosarcoma via activation of β-catenin. Oncotarget. 2016 Nov 22; 7(47):77038-77051. Shimozaki S, Yamamoto N, Domoto T, Nishida H, Hayashi K, Kimura H, Takeuchi A, Miwa S, Igarashi K, Kato T, Aoki Y, Higuchi T, Hirose M, Hoffman RM, Minamoto T, Tsuc