Robert Hoffman

Title(s)Recall Faculty, Surgery
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Overview
    Research Overview
    Our research program centers on cancer with the ultimate goal of developing a general cure.

    Research Topics
    - Angiogenesis
    - Cancer
    - Cell Biology
    - Development
    - Drug Delivery
    - Genetics
    - Genomics
    - Regeneration/Stem Cells
    - Translational Research

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    Collapse Research Activities and Funding
    Establishment of a patient-like mouse models of soft-tissue sarcoma sub-types
    NIH R43CA213649Dec 15, 2016 - Nov 30, 2017
    Role: Principal Investigator
    METHIONINE DEPENDENCE, METHYLATION AND ONCOGENESIS
    NIH K04CA000804Sep 1, 1982 - Aug 31, 1987
    Role: Principal Investigator
    METHIONINE DEPENDENCE, A METABOLIC MARKER IN CANCER
    NIH R01CA027564Sep 1, 1979 - Nov 30, 1993
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Engineered Methioninase-expressing Tumor-targeting Salmonella typhimurium A1-R Inhibits Syngeneic-Cancer Mouse Models by Depleting Tumor Methionine. Cancer Genomics Proteomics. 2025 Mar-Apr; 22(2):247-257. Kubota Y, Zhao M, Han Q, Aoki Y, Masaki N, Obara K, Morinaga S, Mizuta K, Sato M, Bouvet M, Kubota K, Tsunoda T, Hoffman RM. PMID: 39993809.
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    2. Dynamic Fluorescence Imaging of Orally-administered Tumor-targeting Salmonella typhimurium A1-R Expressing Green Fluorescent Protein Trafficking Through the Gastrointestinal System to Target Fibrosarcomas in Nude Mice. In Vivo. 2025 Mar-Apr; 39(2):640-647. Morinaga S, Zhao M, Mizuta K, Kang BM, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 40010967.
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    3. HT1080 Fibrosarcoma With Acquired Trabectedin Resistance: Increased Malignancy But Sustained Sensitivity to Methionine Restriction. In Vivo. 2025 Mar-Apr; 39(2):683-690. Morinaga S, Han Q, Mizuta K, Kang BM, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 40010975.
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    4. Bone Marrow Origin of Mammary Phagocytic Intraductal Macrophages (Foam Cells). Int J Mol Sci. 2025 Feb 17; 26(4). Barsky SH, Mcphail K, Wang J, Hoffman RM, Ye Y. PMID: 40004162; PMCID: PMC11855042.
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    5. Targeting Methionine Addiction of Osteosarcoma with Methionine Restriction to Overcome Drug Resistance: A New Paradigm for a Recalcitrant Disease. Cancers (Basel). 2025 Feb 03; 17(3). Aoki Y, Kubota Y, Masaki N, Tome Y, Bouvet M, Nishida K, Hoffman RM. PMID: 39941872; PMCID: PMC11817422.
      View in: PubMed   Mentions:
    6. Recombinant Methioninase (rMETase) Synergistically Sensitizes Ivermectin-resistant MCF-7 Breast Cancer Cells 9.9 Fold to Low-dose Ivermectin. Anticancer Res. 2025 Feb; 45(2):451-455. Morinaga S, Han Q, Mizuta K, Kang BM, Hozumi C, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39890170.
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    7. Bright and Specific Targeting of Metastatic Lymph Nodes in Orthotopic Mouse Models of Gastric Cancer with a Fluorescent Anti-CEA Antibody. Ann Surg Oncol. 2025 Jan 29. Cox KE, Amirfakhri S, Lwin TM, Hosseini M, Ghosh P, Obonyo M, Hoffman RM, Yazaki PJ, Bouvet M. PMID: 39878844.
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    8. Complete Response (CR) in a Previously-progressing Chronic Lymphocytic Leukemia (CLL) Patient Treated With Methionine Restriction in Combination With First-line Chemotherapy. Cancer Diagn Progn. 2025 Jan-Feb; 5(1):21-26. Morinaga S, Han Q, Mizuta K, Kang BM, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39758229; PMCID: PMC11696344.
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    9. Elevated-c-MYC-expressing Fibrosarcoma Cells With Acquired Gemcitabine Resistance Remain Sensitive to Recombinant Methioninase: A Potential Clinical Strategy for a Recalcitrant Disease. Cancer Diagn Progn. 2025 Jan-Feb; 5(1):8-14. Morinaga S, Han Q, Mizuta K, Kang BM, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39758233; PMCID: PMC11696348.
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    10. Prostate Cancer Patient With Lymph-node Metastasis Treated Only With Methionine Restriction Has Stable Disease for Two Years Demonstrated With PET/CT and PSMA-PET Scanning and PSA Testing. Cancer Diagn Progn. 2025 Jan-Feb; 5(1):27-31. Morinaga S, Han Q, Mizuta K, Kang BM, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39758238; PMCID: PMC11696347.
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    11. Immune Stress-induced Tumor Mutation Burden and Neoantigen Expression in 4T1 Mammary Cancer Cells: A Potential Mechanism for Long-term Survival in Patients Treated With Immune Checkpoint Inhibitors. Cancer Genomics Proteomics. 2025 Jan-Feb; 22(1):1-12. Ishiguro T, Takeda K, Takayanagi D, Mura E, Suzuki R, Tsurui T, Iriguchi N, Hirasawa Y, Ohkuma R, Shimokawa M, Ariizumi H, Kubota Y, Horiike A, Izumizaki M, Wada S, Yoshimura K, Hoffman RM, Tsunoda T. PMID: 39730175; PMCID: PMC11696327.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    12. Ivermectin Combined With Recombinant Methioninase (rMETase) Synergistically Eradicates MiaPaCa-2 Pancreatic Cancer Cells. Anticancer Res. 2025 Jan; 45(1):97-103. Morinaga S, Han Q, Mizuta K, Kang BM, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39740811.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. Comparison of Cell-death Kinetics of Recombinant Methioninase (rMETase)-treated Cancer and Normal Cells: Only Cancer Cells Undergo Methionine-depletion Catastrophe at Low rMETase Concentrations. Anticancer Res. 2025 Jan; 45(1):105-111. Kang BM, Han Q, Mizuta K, Morinaga S, Bouvet M, Hoffman RM. PMID: 39740830.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. Alternating Oxaliplatin and Irinotecan Chemotherapy Combined With Capecitabine and Bevacizumab for Microsatellite-stable Stage IV Metastatic Colon Cancer With a BRAF V600E Mutation: Two Case Reports Indicating Survival Improvement over Standard Therapy. Anticancer Res. 2025 Jan; 45(1):399-404. Zhang Y, Li X, Li S, Yang Z, Hoffman RM, Yu C. PMID: 39740847.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. The Combination of Tumor-targeting Salmonella typhimurium A1-R Plus the Autophagy-inhibitor Chloroquine Synergistically Eradicates HT1080 Fibrosarcoma Cells In Vitro and In Vivo. In Vivo. 2025 Jan-Feb; 39(1):102-109. Morinaga S, Zhao M, Mizuta K, Kang BM, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39740880; PMCID: PMC11705149.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    16. Synergistic Eradication of Fibrosarcoma With Acquired Ifosfamide Resistance Using Methionine Restriction Combined With Ifosfamide in Nude-mouse Models. In Vivo. 2025 Jan-Feb; 39(1):120-126. Morinaga S, Han Q, Mizuta K, Kang BM, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39740911; PMCID: PMC11705138.
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    17. Sub-toxic cisplatin concentrations induce extensive chromosomal, nuclear and nucleolar abnormalities associated with high malignancy before acquired resistance develops: Implications for clinical caution. PLoS One. 2024; 19(12):e0311976. Delinassios JG, Hoffman RM, Koumakis G, Palitskaris D, Poulatsidou KN, Delinasios GJ. PMID: 39724069; PMCID: PMC11670937.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    18. The Potential of Hair-Follicle-Associated Pluripotent (HAP) Stem Cells for Regenerative Medicine. Methods Mol Biol. 2024 Dec 21. Obara K, Baba K, Hamada Y, Hoffman RM. PMID: 39702862.
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    19. Selective Synergy of Recombinant Methioninase Plus Docetaxel Against Docetaxel-resistant and -sensitive Fibrosarcoma Cells Compared to Normal Fibroblasts. Anticancer Res. 2024 Dec; 44(12):5207-5213. Morinaga S, Han Q, Mizuta K, Kang BM, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39626920.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    20. Recombinant Methioninase Synergistically Reverses High-docetaxel Resistance Developed in Osteosarcoma Cells. Anticancer Res. 2024 Nov; 44(11):4773-4778. Morinaga S, Han Q, Mizuta K, Kang BM, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39477291.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    21. Accurate and Safe Tumor Targeting of Orally-administered Salmonella typhimurium A1-R Leads to Regression of an Aggressive Fibrosarcoma in Nude Mice. In Vivo. 2024 Nov-Dec; 38(6):2601-2609. Morinaga S, Zhao M, Mizuta K, Kang BM, Sato M, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39477429; PMCID: PMC11535920.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    22. Serum Exosomes Expressing CD9, CD63 and HER2 From Breast-Cancer Patients Decreased After Surgery of the Primary Tumor: A Potential Biomarker of Tumor Burden. Cancer Genomics Proteomics. 2024 Nov-Dec; 21(6):580-584. Inubushi S, Kunihisa T, Kuniyasu M, Inoue S, Yamamoto M, Yamashita Y, Miki M, Mizumoto S, Baba M, Hoffman RM, Tanino H. PMID: 39467625; PMCID: PMC11534029.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    23. Extensive DNA Damage and Loss of Cell Viability Occur Synergistically With the Combination of Recombinant Methioninase and Paclitaxel on Pancreatic Cancer Cells which Report DNA-Damage Response in Real Time. Cancer Genomics Proteomics. 2024 Nov-Dec; 21(6):585-590. Morinaga S, Han Q, Mizuta K, Kang BM, Sato M, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39467627; PMCID: PMC11534037.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    24. Targeting Human Pancreatic Cancer with a Fluorophore-Conjugated Mucin 4 (MUC4) Antibody: Initial Characterization in Orthotopic Cell Line Mouse Models. J Clin Med. 2024 Oct 18; 13(20). Jaiswal S, Cox KE, Amirfakhri S, Din Parast Saleh A, Kobayashi K, Lwin TM, Talib S, Aithal A, Mallya K, Jain M, Mohs AM, Hoffman RM, Batra SK, Bouvet M. PMID: 39458160; PMCID: PMC11508345.
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    25. Lymphovascular Tumoral Emboli in Inflammatory Breast Cancer Result from Haptotaxis-Mediated Encircling Lymphangiogenesis. Lymphatics. 2024 Dec; 2(4):195-211. Wang J, Hoffman RM, Ye Y, Dillard J, Barsky SH. PMID: 39669476; PMCID: PMC11632961.
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    26. Loss of Malignancy of Super-Methotrexate-resistant Osteosarcoma Cells Is Associated With an Increase of Methylated Histone Marks H3K9me3 and H3K27me3. Anticancer Res. 2024 Oct; 44(10):4213-4218. Aoki Y, Kubota Y, Masaki N, Obara K, Tome Y, Bouvet M, Nishida K, Hoffman RM. PMID: 39348992.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    27. Accurate Co-Localization of Luciferase Expression and Fluorescent Anti-CEA Antibody Targeting of Liver Metastases in an Orthotopic Mouse Model of Colon Cancer. Cancers (Basel). 2024 Sep 29; 16(19). Lee KH, Cox KE, Amirfakhri S, Jaiswal S, Liu S, Hosseini M, Lwin TM, Yazaki PJ, Hoffman RM, Bouvet M. PMID: 39409961; PMCID: PMC11475688.
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    28. Non-Invasive Direct Visualization of Luciferase-Luciferin Emitted Light Producing True Images from an Orthotopic Lung Cancer Xenograft Model in Nude Mice Using an Ultra-sensitive Low-light Camera and Optics. In Vivo. 2024 Sep-Oct; 38(5):2122-2125. Mizuta K, Gallagher S, Wang A, Chang N, Morinaga S, Sato M, Kang BM, Hoffman RM. PMID: 39187316; PMCID: PMC11363753.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    29. EL4 Murine-Lymphoma-Stromal-Cell Fusion Hybrids Observed With Multiple Distinct Morphologies in the Primary Tumor and Metastatic Organs of a Syngeneic Mouse Model. In Vivo. 2024 Sep-Oct; 38(5):2115-2121. Yamashita K, Suetsugu A, Hayashi S, Shimizu M, Hoffman RM. PMID: 39187323; PMCID: PMC11363744.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    30. First-line Chemotherapy in Combination With Oral Recombinant Methioninase and a Low-methionine Diet for a Stage IV Inoperable Pancreatic-Cancer Patient Resulted in 40% Tumor Reduction and an 86% CA19-9 Biomarker Decrease. Anticancer Res. 2024 Sep; 44(9):3885-3889. Sato M, Han Q, Hozumi C, Kujiraoka H, Mizuta K, Morinaga S, Kang BM, Kobayashi N, Ichikawa Y, Nakajima A, Hoffman RM. PMID: 39197890.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. [11C]Methionine PET vs. [18F]Fluorodeoxyglucose PET Whole-body Imaging to Determine the Extent of Methionine-addiction Compared to Glucose-addiction of Primary and Metastatic Cancer of the Trunk in Patients. Anticancer Res. 2024 Sep; 44(9):3891-3898. Sato M, Sato T, Hozumi C, Han Q, Mizuta K, Morinaga S, Kang BM, Kobayashi N, Ichikawa Y, Nakajima A, Hoffman RM. PMID: 39197923.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    32. Overcoming High Trabectedin Resistance of Soft-tissue Sarcoma With Recombinant Methioninase: A Potential Solution of a Recalcitrant Clinical Problem. Anticancer Res. 2024 Sep; 44(9):3785-3791. Morinaga S, Han Q, Mizuta K, Kang BM, Sato M, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39197928.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    33. Recombinant Methioninase Increases Eribulin Efficacy 16-fold in Highly Eribulin-resistant HT1080 Fibrosarcoma Cells, Demonstrating Potential to Overcome the Clinical Challenge of Drug-resistant Soft-tissue Sarcoma. Anticancer Res. 2024 Sep; 44(9):3777-3783. Morinaga S, Han Q, Mizuta K, Kang BM, Sato M, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39197933.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    34. Imaging Transgenic Nude Mice Expressing Spectrally-distinct Fluorescent Reporters Emitting From Blue to Far Red Light With One Instrument With Single-nanometer-tuning of Laser-excitation Fluorescence. Cancer Diagn Progn. 2024 Sep-Oct; 4(5):563-566. Mizuta K, Reynoso J, Gallagher S, Wang A, Chang N, Morinaga S, Sato M, Kang BM, Hoffman RM. PMID: 39238628; PMCID: PMC11372684.
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    35. The Role of Microsurgery and Fluorescent-reporter Genes in Establishing Mouse Models for Real-Time Imaging of Metastatic Cancer-Cell Trafficking and Colony Formation: A Revolutionary and Disruptive Technology for Metastasis Research. Cancer Diagn Progn. 2024 Sep-Oct; 4(5):544-557. Morinaga S, Yamamoto N, Yamauchi K, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39238629; PMCID: PMC11372698.
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    36. Recombinant Methioninase Is Selectively Synergistic With Doxorubicin Against Wild-type Fibrosarcoma Cells Compared to Normal Cells and Overcomes Highly-Doxorubicin-resistant Fibrosarcoma. Anticancer Res. 2024 Aug; 44(8):3261-3268. Morinaga S, Han Q, Mizuta K, Kang BM, Sato M, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 39060039.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    37. Exosome Transfer Between Different Co-implanted Human Pancreatic Cancer Cell Lines Occurs in the Primary Tumor and Multiple Metastatic Sites of Nude Mice But Not in Co-Culture In Vitro. Anticancer Res. 2024 Aug; 44(8):3307-3315. Yamashita K, Suetsugu A, Hayashi S, Shimizu M, Hoffman RM. PMID: 39060068.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    38. Maximum Efficacy of Immune Checkpoint Inhibitors Occurs in Esophageal Cancer Patients With a Low Neutrophil-to-Lymphocyte Ratio and Good Performance Status Prior to Treatment. Anticancer Res. 2024 Aug; 44(8):3397-3407. Hirasawa Y, Kubota Y, Mura E, Suzuki R, Tsurui T, Iriguchi N, Ishiguro T, Ohkuma R, Shimokawa M, Ariizumi H, Horiike A, Wada S, Ariyoshi T, Goto S, Otsuka K, Murakami M, Kiuchi Y, Yoshimura K, Hoffman RM, Tsunoda T. PMID: 39060084.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    39. The Combination of Methionine Restriction and Docetaxel Synergistically Arrests Androgen-independent Prostate Cancer But Not Normal Cells. Cancer Diagn Progn. 2024 Jul-Aug; 4(4):402-407. Mizuta K, Mori R, Han Q, Morinaga S, Sato M, Kang BM, Bouvet M, Tome Y, Nishida K, Hoffman RM. PMID: 38962551; PMCID: PMC11215443.
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    40. Synergy of Rapamycin and Methioninase on Colorectal Cancer Cells Requires Simultaneous and Not Sequential Administration: Implications for mTOR Inhibition. Cancer Diagn Progn. 2024 Jul-Aug; 4(4):396-401. Ardjmand D, Sato M, Han Q, Kubota Y, Mizuta K, Morinaga S, Hoffman RM. PMID: 38962555; PMCID: PMC11215436.
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    41. Head-to-head Comparison of Green Fluorescent Protein (GFP) Imaging With Luciferase-luciferin Imaging In Vivo Using Single-nanometer Laser-excitation Tuning and an Ultra-low-light-detection Camera and Optics Demonstrates the Superiority of GFP. Anticancer Res. 2024 Jul; 44(7):2823-2826. Mizuta K, Gallagher S, Wang A, Chang N, Morinaga S, Sato M, Kang BM, Hoffman RM. PMID: 38925805.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    42. Reduced Malignancy of Super Methotrexate-resistant Osteosarcoma Cells With Dihydrofolate Reductase Amplification Despite Paradoxical Gain of Oncogenic PI3K/AKT/mTOR and c-MYC expression. Anticancer Res. 2024 Jul; 44(7):2787-2792. Aoki Y, Kubota Y, Masaki N, Obara K, Tome Y, Bouvet M, Nishida K, Hoffman RM. PMID: 38925854.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    43. Expression of PD-L1 Is Increased by Methionine Restriction Using Recombinant Methioninase in Human Colorectal Cancer Cells. Cancer Genomics Proteomics. 2024 Jul-Aug; 21(4):395-398. Mizuta K, Kang BM, Han Q, Kubota Y, Morinaga S, Sato M, Bouvet M, Tome Y, Nishida K, Hoffman RM. PMID: 38944421; PMCID: PMC11215431.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    44. Induction of the DNA-Repair Gene POLQ only in BRCA1-mutant Breast-Cancer Cells by Methionine Restriction. Cancer Genomics Proteomics. 2024 Jul-Aug; 21(4):399-404. Kunihisa T, Inubushi S, Tanino H, Hoffman RM. PMID: 38944428; PMCID: PMC11215430.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    45. Targeting Patient-Derived Orthotopic Gastric Cancers with a Fluorescent Humanized Anti-CEA Antibody. Ann Surg Oncol. 2024 Sep; 31(9):6291-6299. Cox KE, Turner MA, Lwin TM, Amirfakhri S, Kelly KJ, Hosseini M, Ghosh P, Obonyo M, Hoffman RM, Yazaki PJ, Bouvet M. PMID: 38888861; PMCID: PMC11300635.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    46. Hair-follicle associated pluripotent (HAP)-cell-sheet implantation enhanced wound healing in diabetic db/db mice. PLoS One. 2024; 19(6):e0304676. Hasegawa-Haruki A, Obara K, Takaoka N, Shirai K, Hamada Y, Arakawa N, Aki R, Hoffman RM, Amoh Y. PMID: 38875234; PMCID: PMC11178214.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    47. DNA-Binding Agent Trabectedin Combined With Recombinant Methioninase Is Synergistic to Decrease Fibrosarcoma Cell Viability and Induce Nuclear Fragmentation But Not Synergistic on Normal Fibroblasts. Anticancer Res. 2024 Jun; 44(6):2359-2367. Morinaga S, Han Q, Kubota Y, Mizuta K, Kang BM, Sato M, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. PMID: 38821601.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    48. The potential of methioninase for cancer treatment. Biochim Biophys Acta Rev Cancer. 2024 07; 1879(4):189122. Abo Qoura L, Balakin KV, Hoffman RM, Pokrovsky VS. PMID: 38796027.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    49. Efficacy of Recombinant Methioninase on Late-stage Patient Cancer in the Histoculture Drug Response Assay (HDRA) as a Potential Functional Biomarker of Sensitivity to Methionine-restriction Therapy in the Clinic. Cancer Diagn Progn. 2024 May-Jun; 4(3):239-243. Kubota Y, Sasaki M, Han Q, Hozumi C, Tsunoda T, Hoffman RM. PMID: 38707720; PMCID: PMC11062157.
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    50. Extensive Shrinkage and Long-term Stable Disease in a Teenage Female Patient With High-grade Glioma Treated With Temozolomide and Radiation in Combination With Oral Recombinant Methioninase and a Low-methionine Diet. In Vivo. 2024 May-Jun; 38(3):1459-1464. Sato M, Han Q, Mizuta K, Mori R, Kang BM, Morinaga S, Kobayashi N, Ichikawa Y, Nakajima A, Hoffman RM. PMID: 38688589; PMCID: PMC11059867.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    51. Targeting Methionine Addiction Combined With Low-dose Irinotecan Arrested Colon Cancer in Contrast to High-dose Irinotecan Alone, Which Was Ineffective, in a Nude-mouse Model. In Vivo. 2024 May-Jun; 38(3):1058-1063. Sato M, Mizuta K, Han Q, Morinaga S, Kang BM, Kubota Y, Mori R, Baranov A, Kobayashi K, Ardjmand D, Kobayashi N, Bouvet M, Ichikawa Y, Nakajima A, Hoffman RM. PMID: 38688611; PMCID: PMC11059914.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    52. Methionine Dependence of Hair Maintenance in C57BL/6 Mice. In Vivo. 2024 May-Jun; 38(3):1199-1202. Kubota Y, Varshney N, Kobayashi K, Tsunoda T, Hoffman RM. PMID: 38688645; PMCID: PMC11059892.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    53. Reduction of Tumor Biomarkers from very High to Normal and Extensive Metastatic Lesions to Undetectability in a Patient With Stage IV HER2-positive Breast Cancer Treated With Low-dose Trastuzumab Deruxtecan in Combination With Oral Recombinant Methioninase and a Low-methionine Diet. Anticancer Res. 2024 Apr; 44(4):1499-1504. Sato M, Han Q, Mori R, Mizuta K, Kang BM, Morinaga S, Kobayashi N, Ichikawa Y, Nakajima A, Hoffman RM. PMID: 38538002.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    54. Anlotinib Inhibits Ovarian Cancer and Enhances Cisplatinum Sensitivity via Suppressing NOTCH2 Expression and Stemness. Anticancer Res. 2024 Apr; 44(4):1399-1407. Xu X, Wang Q, Shen L, Shen Y, Liu H, Liu Y, Yang Z, Hoffman RM, Feng W. PMID: 38538004.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    55. Selective Synergy of Rapamycin Combined With Methioninase on Cancer Cells Compared to Normal Cells. Anticancer Res. 2024 Mar; 44(3):929-933. Ardjmand D, Kubota Y, Sato M, Han Q, Mizuta K, Morinaga S, Hoffman RM. PMID: 38423628.
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    56. Extensive Synergy Between Recombinant Methioninase and Eribulin Against Fibrosarcoma Cells But Not Normal Fibroblasts. Anticancer Res. 2024 Mar; 44(3):921-928. Morinaga S, Han Q, Kubota Y, Mizuta K, Kang BM, Sato M, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Hoffman RM. PMID: 38423656.
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    57. The Expression of the Claudin Family of Proteins in Colorectal Cancer. Biomolecules. 2024 Feb 24; 14(3). Cox KE, Liu S, Hoffman RM, Batra SK, Dhawan P, Bouvet M. PMID: 38540693; PMCID: PMC10967842.
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    58. Rat hair-follicle-associated pluripotent (HAP) stem cells can differentiate into atrial or ventricular cardiomyocytes in culture controlled by specific supplementation. PLoS One. 2024; 19(1):e0297443. Takaoka N, Yamane M, Hasegawa A, Obara K, Shirai K, Aki R, Hatakeyama H, Hamada Y, Arakawa N, Tanaka M, Hoffman RM, Amoh Y. PMID: 38277391; PMCID: PMC10817212.
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    59. Precise Non-invasive Imaging Mouse Model of Pancreatic Cancer: Very Narrow Band-width Laser Fluorescence Excitation of Green Fluorescent Protein Provides Ultra-bright Tumor Images With no Skin Autofluorescence. Cancer Diagn Progn. 2024 Jan-Feb; 4(1):30-33. Kubota Y, Wang A, Chang N, Tarantino S, Gallagher S, Aoki Y, Masaki N, Obara K, Morinaga S, Tsunoda T, Hoffman RM. PMID: 38173656; PMCID: PMC10758840.
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    60. Non-invasive Fluorescence Imaging of Breast Cancer Metastasis to the Brain in an Orthotopic Nude-mouse Model With Very-narrow-band-width Laser Excitation of Red Fluorescent Protein Resulting in an Ultra-bright Signal Without Skin Autofluorescence. In Vivo. 2024 Jan-Feb; 38(1):69-72. Kubota Y, Aoki Y, Wang A, Chang N, Tarantino S, Gallagher S, Tsunoda T, Hoffman RM. PMID: 38148053; PMCID: PMC10756473.
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    61. [11C] Methionine-PET Imaging as a Cancer Biomarker for Methionine Addiction and Sensitivity to Methionine-restriction-based Combination Chemotherapy. In Vivo. 2024 Jan-Feb; 38(1):253-258. Kubota Y, Sato T, Han Q, Hozumi C, Morinaga S, Mizuta K, Tsunoda T, Hoffman RM. PMID: 38148095; PMCID: PMC10756438.
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    62. Non-classical Monocytes Enhance the Efficacy of Immune Checkpoint Inhibitors on Colon Cancer in a Syngeneic Mouse Model. Anticancer Res. 2024 Jan; 44(1):23-29. Goshima T, Ieguchi K, Onishi N, Shimizu T, Takayanagi D, Watanabe M, Fujimoto Y, Ohkuma R, Suzuki R, Tsurui T, Mura E, Iriguchi N, Ishiguro T, Shimokawa M, Hirasawa Y, Kubota Y, Ariizumi H, Horiike A, Yoshimura K, Tsuji M, Kiuchi Y, Kobayashi S, Fujishiro J, Hoffman RM, Tsunoda T, Wada S. PMID: 38159965.
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    63. Recombinant Methioninase Decreased the Effective Dose of Irinotecan by 15-fold Against Colon Cancer Cells: A Strategy for Effective Low-toxicity Treatment of Colon Cancer. Anticancer Res. 2024 Jan; 44(1):31-35. Sato M, Han Q, Kubota Y, Baranov A, Ardjmand D, Mizuta K, Morinaga S, Kang BM, Kobayashi N, Bouvet M, Ichikawa Y, Nakajima A, Hoffman RM. PMID: 38159986.
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    64. Methionine restriction of glioma does not induce MGMT and greatly improves temozolomide efficacy in an orthotopic nude-mouse model: A potential curable approach to a clinically-incurable disease. Biochem Biophys Res Commun. 2024 02 05; 695:149418. Kubota Y, Aoki Y, Masaki N, Obara K, Hamada K, Han Q, Bouvet M, Tsunoda T, Hoffman RM. PMID: 38176171.
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    65. Asymmetric and symmetric protein arginine methylation in methionine-addicted human cancer cells. PLoS One. 2023; 18(12):e0296291. Holtz AG, Lowe TL, Aoki Y, Kubota Y, Hoffman RM, Clarke SG. PMID: 38134182; PMCID: PMC10745221.
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    66. The Combination of Methioninase and Ethionine Exploits Methionine Addiction to Selectively Eradicate Osteosarcoma Cells and Not Normal Cells and Synergistically Down-regulates the Expression of C-MYC. Cancer Genomics Proteomics. 2023 Dec; 20(6suppl):679-685. Aoki Y, Kubota Y, Han Q, Masaki N, Obara K, Bouvet M, Chawla SP, Tome Y, Nishida K, Hoffman RM. PMID: 38035708; PMCID: PMC10687729.
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    67. Recombinant Methioninase Lowers the Effective Dose of Regorafenib Against Colon-Cancer Cells: A Strategy for Widespread Clinical Use of a Toxic Drug. Cancer Diagn Progn. 2023 Nov-Dec; 3(6):655-659. Choobin BB, Kubota Y, Han Q, Ardjmand D, Morinaga S, Mizuta K, Bouvet M, Tsunoda T, Hoffman RM. PMID: 37927805; PMCID: PMC10619565.
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    68. Recombinant-methioninase-producing Escherichia coli Instilled in the Microbiome Inhibits Triple-negative Breast Cancer in an Orthotopic Cell-line Mouse Model. Cancer Diagn Progn. 2023 Nov-Dec; 3(6):649-654. Kubota Y, Han Q, Morinaga S, Mizuta K, Bouvet M, Tsunoda T, Hoffman RM. PMID: 37927811; PMCID: PMC10619576.
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    69. Non-invasive omics analysis delineates molecular changes in water-only fasting and its sex-discriminating features in metabolic syndrome patients. MedComm (2020). 2023 Dec; 4(6):e393. Jiang Y, Tang Z, Zhu X, Xiao B, Tian H, Lei X, Peng H, Qin J, Zhang Y, Hoffman RM, Hu X, Chen Q, Ji G, Jia L. PMID: 37929015; PMCID: PMC10622739.
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    70. Erratum: ATR inhibition sensitizes liposarcoma to doxorubicin by increasing DNA damage. Am J Cancer Res. 2023; 13(10):5021-5023. Cui J, Dean D, Hornicek FJ, Pollock RE, Hoffman RM, Duan Z. PMID: 37970365; PMCID: PMC10636686.
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    71. Humanized Anti-Carcinoembryonic Antigen Antibodies Brightly Target and Label Gastric Cancer in Orthotopic Mouse Models. J Surg Res. 2024 01; 293:701-708. Cox KE, Turner MA, Amirfakhri S, Lwin TM, Hosseini M, Ghosh P, Obonyo M, Murakami T, Hoffman RM, Yazaki PJ, Bouvet M. PMID: 37839102; PMCID: PMC11060874.
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    72. High Clinical Concordance of Drug Resistance in Patient-derived Orthotopic Xenograft (PDOX) Mouse Models: First Step to Validated Precise Individualized Cancer Chemotherapy. Anticancer Res. 2023 Oct; 43(10):4277-4284. Higuchi T, Yamamoto N, Hayashi K, Miwa S, Igarashi K, Tsuchiya H, Hoffman RM. PMID: 37772554.
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    73. Methionine Restriction Increases Exosome Production and Secretion in Breast Cancer Cells. Cancer Genomics Proteomics. 2023 Sep-Oct; 20(5):412-416. Inubushi S, Kunihisa T, Mizumoto S, Inoue S, Miki M, Suetsugu A, Tanino H, Hoffman RM. PMID: 37643781; PMCID: PMC10464940.
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    74. Rapid Reduction of CEA and Stable Metastasis in an NRAS-mutant Rectal-Cancer Patient Treated With FOLFIRI and Bevacizumab Combined With Oral Recombinant Methioninase and a Low-Methionine Diet Upon Metastatic Recurrence After FOLFIRI and Bevacizumab Treatment Alone. In Vivo. 2023 Sep-Oct; 37(5):2134-2138. Kubota Y, Han Q, Morinaga S, Tsunoda T, Hoffman RM. PMID: 37652473; PMCID: PMC10500498.
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    75. SLC26A3/NHERF2-IκB/NFκB/p65 feedback loop suppresses tumorigenesis and metastasis in colorectal cancer. Oncogenesis. 2023 Aug 12; 12(1):41. Lin C, Lin P, Lin H, Yao H, Liu S, He R, Chen H, Teng Z, Hoffman RM, Ye J, Zhu G. PMID: 37573425; PMCID: PMC10423209.
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    76. PEGylated Fluorescent Anti-carcinoembryonic Antigen Antibody Labels Colorectal Cancer Tumors in Orthotopic Mouse Models. J Surg Res. 2023 11; 291:596-602. Turner MA, Amirfakhri S, Nishino H, Neel NC, Hosseini M, Cox KE, Lwin TM, Li L, Hong T, Sherman A, Shively JE, Hoffman RM, Yazaki PJ, Bouvet M. PMID: 37540977.
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    77. Long-lasting Limb Salvage After Malignant Femoral-Bone Tumor Resection Reconstructed With a Thin-mantle Titanium Stem Fixated With Cement. Anticancer Res. 2023 Aug; 43(8):3507-3511. Aoki Y, Tome Y, Oshiro H, Mizuta K, Katsuki R, Hoffman RM, Nishida K. PMID: 37500137.
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    78. Positive Circumferential Resection Margin in Rectal Cancer Is a Robust Predictor of Poor Long-term Prognosis With Clinicopathological Bias Between Groups Compensated by Propensity-score Matching Analysis. Anticancer Res. 2023 Aug; 43(8):3623-3630. Sugimoto K, Takahashi H, Irie T, Kawaguchi M, Kobari A, Amemiya K, Tsuchiya Y, Motegi S, Tsukamoto R, Honjo K, Okazawa YU, Kawai M, Ishiyama S, Takahashi M, Hoffman RM, Sakamoto K. PMID: 37500146.
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    79. Bioinformatics Analysis of Immune Infiltration In Endometrial Carcinoma Tumors and its Relationship With Prognosis. Cancer Diagn Progn. 2023 Jul-Aug; 3(4):416-427. Lin Y, Liu S, Bian L, Lin C, Lin P, Teng Z, Hoffman RM, Zhu G, Zhang B. PMID: 37405226; PMCID: PMC10316055.
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    80. Targeting Methionine Addiction of Cancer Cells with Methioninase. Biochemistry (Mosc). 2023 Jul; 88(7):944-952. Pokrovsky VS, Qoura LA, Demidova EA, Han Q, Hoffman RM. PMID: 37751865.
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    81. Meckel's Diverticulum Carcinoma Is Arrested by Oxaliplatinum and Eradicated by 5-Fluorouracil in a PDX Mouse Model Indicating Candidate First-line Treatment for a Rare Cancer. In Vivo. 2023 Jul-Aug; 37(4):1482-1485. Masaki N, Yonemura Y, Hozumi C, Obara K, Kubota Y, Aoki Y, Hoffman RM. PMID: 37369464; PMCID: PMC10347928.
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    82. Precise and Facile Endotracheal Lung-tumor-implantation Mouse Model Visualized by GFP Expression. In Vivo. 2023 Jul-Aug; 37(4):1477-1481. Aoki Y, Kobayashi KJ, Varshney N, Kubota Y, Masaki N, Obara K, Wang JD, Tome Y, Bouvet M, Nishida K, Hoffman RM. PMID: 37369517; PMCID: PMC10347943.
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    83. Targeting Autophagy With the Synergistic Combination of Chloroquine and Rapamycin as a Novel Effective Treatment for Well-differentiated Liposarcoma. Cancer Genomics Proteomics. 2023 Jul-Aug; 20(4):317-322. Masaki N, Aoki Y, Obara K, Kubota Y, Bouvet M, Miyazaki J, Hoffman RM. PMID: 37400145; PMCID: PMC10320558.
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    84. Old-age-induced obesity reversed by a methionine-deficient diet or oral administration of recombinant methioninase-producing Escherichia coli in C57BL/6 mice. Aging (Albany NY). 2023 06 09; 15(11):4642-4648. Kubota Y, Han Q, Reynoso J, Aoki Y, Masaki N, Obara K, Hamada K, Bouvet M, Tsunoda T, Hoffman RM. PMID: 37301544; PMCID: PMC10292902.
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    85. Colon-cancer liver metastasis is effectively targeted by recombinant methioninase (rMETase) in an orthotopic mouse model. Tissue Cell. 2023 Aug; 83:102125. Miyake K, Han Q, Murakami T, Kiyuna T, Kawaguchi K, Igarashi K, Lwin TM, Miyake M, Yamamoto J, Bouvet M, Endo I, Hoffman RM. PMID: 37320867.
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    86. Highly Selective Targeting of Pancreatic Cancer in the Liver with a Near-Infrared Anti-MUC5AC Probe in a PDOX Mouse Model: A Proof-of-Concept Study. J Pers Med. 2023 May 20; 13(5). Turner MA, Cox KE, Neel N, Amirfakhri S, Nishino H, Clary BM, Hosseini M, Natarajan G, Mallya K, Mohs AM, Hoffman RM, Batra SK, Bouvet M. PMID: 37241027; PMCID: PMC10221372.
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    87. Synergy of Combining Methionine Restriction and Chemotherapy: The Disruptive Next Generation of Cancer Treatment. Cancer Diagn Progn. 2023 May-Jun; 3(3):272-281. Kubota Y, Han Q, Aoki Y, Masaki N, Obara K, Hamada K, Hozumi C, Wong ACW, Bouvet M, Tsunoda T, Hoffman RM. PMID: 37168964; PMCID: PMC10165382.
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    88. Specific Targeting and Labeling of Colonic Polyps in CPC-APC Mice with Mucin 5AC Fluorescent Antibodies: A Model for Detection of Early Colon Cancer. Curr Issues Mol Biol. 2023 Apr 11; 45(4):3347-3358. Turner MA, Cox KE, Liu S, Neel N, Amirfakhri S, Nishino H, Hosseini M, Alcantara JA, Abd El-Hafeez AA, Lwin TM, Mallya K, Pisegna JR, Singh SK, Ghosh P, Hoffman RM, Batra SK, Bouvet M. PMID: 37185743; PMCID: PMC10136452.
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    89. Oncogenes and Methionine Addiction of Cancer: Role of c-MYC. Cancer Genomics Proteomics. 2023 Mar-Apr; 20(2):165-170. Aoki Y, Han Q, Kubota Y, Masaki N, Obara K, Tome Y, Bouvet M, Nishida K, Hoffman RM. PMID: 36870694; PMCID: PMC9989672.
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    90. The Mucin Family of Proteins: Candidates as Potential Biomarkers for Colon Cancer. Cancers (Basel). 2023 Feb 27; 15(5). Cox KE, Liu S, Lwin TM, Hoffman RM, Batra SK, Bouvet M. PMID: 36900282; PMCID: PMC10000725.
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    91. Superiority of [11C]methionine over [18F]deoxyglucose for PET Imaging of Multiple Cancer Types Due to the Methionine Addiction of Cancer. Int J Mol Sci. 2023 Jan 18; 24(3). Kubota Y, Sato T, Hozumi C, Han Q, Aoki Y, Masaki N, Obara K, Tsunoda T, Hoffman RM. PMID: 36768257; PMCID: PMC9915427.
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    92. Direct implantation of hair-follicle-associated pluripotent (HAP) stem cells repairs intracerebral hemorrhage and reduces neuroinflammation in mouse model. PLoS One. 2023; 18(1):e0280304. Obara K, Shirai K, Hamada Y, Arakawa N, Hasegawa A, Takaoka N, Aki R, Hoffman RM, Amoh Y. PMID: 36638123; PMCID: PMC9838830.
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    93. TRAF6 regulates the abundance of RIPK1 and inhibits the RIPK1/RIPK3/MLKL necroptosis signaling pathway and affects the progression of colorectal cancer. Cell Death Dis. 2023 01 05; 14(1):6. Lin P, Lin C, He R, Chen H, Teng Z, Yao H, Liu S, Hoffman RM, Ye J, Zhu G. PMID: 36604411; PMCID: PMC9816173.
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    94. Recombinant Oral Methioninase (o-rMETase) Combined With Oxaliplatinum Plus 5-Fluorouracil Improves Survival of Mice With Massive Colon-Cancer Peritoneal Carcinomatosis. Anticancer Res. 2023 Jan; 43(1):19-24. Kim MJ, Han Q, Bouvet M, Hoffman RM, Park JH. PMID: 36585181.
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    95. Elevated Pro-inflammatory Cytokine Levels in Acute Reflux Esophagitis Are Reduced by 1,25 Dihydroxy Vitamin D3. In Vivo. 2023 Jan-Feb; 37(1):79-87. Wei J, Zhang J, Jiang Y, Lian T, Zhang P, Hoffman RM, Zhu G, Zhuang Z. PMID: 36593017; PMCID: PMC9843781.
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    96. Synergy of oral recombinant methioninase (rMETase) and 5-fluorouracil on poorly differentiated gastric cancer. Biochem Biophys Res Commun. 2023 Feb 05; 643:48-54. Miyake M, Miyake K, Han Q, Igarashi K, Kawaguchi K, Barangi M, Kiyuna T, Sugisawa N, Higuchi T, Oshiro H, Zhang Z, Razmjooei S, Bouvet M, Endo I, Hoffman RM. PMID: 36586158.
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    97. Hair follicle associated pluripotent (HAP) stem cells jump from transplanted whiskers to pelage follicles and stimulate hair growth. Sci Rep. 2022 12 07; 12(1):21174. Obara K, Reynoso J, Hamada Y, Aoki Y, Kubota Y, Masaki N, Amoh Y, Hoffman RM. PMID: 36476963; PMCID: PMC9729176.
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    98. Elimination of Axillary-Lymph-Node Metastases in a Patient With Invasive Lobular Breast Cancer Treated by First-line Neo-adjuvant Chemotherapy Combined With Methionine Restriction. Anticancer Res. 2022 Dec; 42(12):5819-5823. Kubota Y, Han Q, Masaki N, Hozumi C, Hamada K, Aoki Y, Obara K, Tsunoda T, Hoffman RM. PMID: 36456116.
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    99. Reversion of methionine addiction of osteosarcoma cells to methionine independence results in loss of malignancy, modulation of the epithelial-mesenchymal phenotype and alteration of histone-H3 lysine-methylation. Front Oncol. 2022; 12:1009548. Aoki Y, Han Q, Tome Y, Yamamoto J, Kubota Y, Masaki N, Obara K, Hamada K, Wang JD, Inubushi S, Bouvet M, Clarke SG, Nishida K, Hoffman RM. PMID: 36408173; PMCID: PMC9671209.
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    100. Oral Installation of Recombinant Methioninase-producing Escherichia coli into the Microbiome Inhibits Colon-cancer Growth in a Syngeneic Mouse Model. Cancer Genomics Proteomics. 2022 Nov-Dec; 19(6):683-691. Kubota Y, Han Q, Hamada K, Aoki Y, Masaki N, Obara K, Baranov A, Bouvet M, Tsunoda T, Hoffman RM. PMID: 36316039; PMCID: PMC9620449.
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    101. Oral-recombinant Methioninase Lowers the Effective Dose and Eliminates Toxicity of Cisplatinum for Primary Osteosarcoma of the Mammary Gland in a Patient-derived Orthotopic Xenograft Mouse Model. In Vivo. 2022 Nov-Dec; 36(6):2598-2603. Masaki N, Han Q, Wu NF, Samonte C, Wu J, Hozumi C, Obara K, Kubota Y, Aoki Y, Miyazaki J, Hoffman RM. PMID: 36309364; PMCID: PMC9677772.
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    102. Chloroquine Combined With Rapamycin Arrests Tumor Growth in a Patient-derived Orthotopic Xenograft (PDOX) Mouse Model of Dedifferentiated Liposarcoma. In Vivo. 2022 Nov-Dec; 36(6):2630-2637. Masaki N, Aoki Y, Kubota Y, Obara K, Miyazaki J, Hoffman RM. PMID: 36309387; PMCID: PMC9677795.
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    103. Oral-recombinant Methioninase in Combination With Rapamycin Eradicates Osteosarcoma of the Breast in a Patient-derived Orthotopic Xenograft Mouse Model. Anticancer Res. 2022 Nov; 42(11):5217-5222. Masaki N, Han Q, Samonte C, Wu NF, Hozumi C, Wu J, Obara K, Kubota Y, Aoki Y, Bouvet M, Hoffman RM. PMID: 36288875.
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    104. Evodiamine inhibits ESCC by inducing M-phase cell-cycle arrest via CUL4A/p53/p21 axis and activating noxa-dependent intrinsic and DR4-dependent extrinsic apoptosis. Phytomedicine. 2023 Jan; 108:154493. Zhang L, Li L, Chen X, Yuan S, Xu T, Zhao W, Li M, Wang F, Hoffman RM, Jia L. PMID: 36265256.
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    105. Long-chain Non-coding RNA MIR4435-2HG Expression Correlates With Size of Intestinal Polyps in Children and With Metastasis of Colon Cancer. Anticancer Res. 2022 Oct; 42(10):4707-4714. Zhu D, Guo P, Jin XY, Zhang R, Ji G, Yang Z, Hoffman RM, Sheng W. PMID: 36191994.
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    106. Micro RNA miR-1303 Promotion of Proliferation, Migration and Invasion of Human Liver Cancer Cells Is Enhanced by Low Talin 1 (TLN1) Expression. Anticancer Res. 2022 Oct; 42(10):4715-4725. Huang J, Xi Q, Xiong J, Peng H, Yang H, Sun YU, Hoffman RM. PMID: 36192016.
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    107. Inhibition of pancreatic cancer-cell growth and metastasis in vivo by a pyrazole compound characterized as a cell-migration inhibitor by an in vitro chemotaxis assay. Biomed Pharmacother. 2022 Nov; 155:113733. Okamoto S, Miyano K, Choshi T, Sugisawa N, Nishiyama T, Kotouge R, Yamamura M, Sakaguchi M, Kinoshita R, Tomonobu N, Katase N, Sasaki K, Nishina S, Hino K, Kurose K, Oka M, Kubota H, Ueno T, Hirai T, Fujiwara H, Kawai C, Itadani M, Morihara A, Matsushima K, Kanegasaki S, Hoffman RM, Yamauchi A, Kuribayashi F. PMID: 36271542.
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    108. Resistance to tyrosine kinase inhibitors promotes renal cancer progression through MCPIP1 tumor-suppressor downregulation and c-Met activation. Cell Death Dis. 2022 09 22; 13(9):814. Marona P, Górka J, Kwapisz O, Jura J, Rys J, Hoffman RM, Miekus K. PMID: 36138026; PMCID: PMC9500022.
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    109. Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells. Signal Transduct Target Ther. 2022 09 09; 7(1):313. Ni S, Liu Q, Chen X, Ding L, Cai L, Mao F, Shi D, Hoffman RM, Li J, Jia L. PMID: 36075909; PMCID: PMC9458665.
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    110. Proof of Principle of Combining Fluorescence-Guided Surgery with Photoimmunotherapy to Improve the Outcome of Pancreatic Cancer Therapy in an Orthotopic Mouse Model. Ann Surg Oncol. 2023 Jan; 30(1):618-625. Nishino H, Turner MA, Amirfakhri S, Lwin TM, Hosseini M, Singer BB, Hoffman RM, Bouvet M. PMID: 36057899; PMCID: PMC9726788.
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    111. Review: Precise sarcoma patient-derived orthotopic xenograft (PDOX) mouse models enable identification of novel effective combination therapies with the cyclin-dependent kinase inhibitor palbociclib: A strategy for clinical application. Front Oncol. 2022; 12:957844. Higuchi T, Igarashi K, Yamamoto N, Hayashi K, Kimura H, Miwa S, Bouvet M, Tsuchiya H, Hoffman RM. PMID: 36003796; PMCID: PMC9393494.
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    112. Proof of concept of improved fluorescence-guided surgery of colon cancer liver metastasis using color-coded imaging of a tumor-labeling fluorescent antibody and indocyanine green restricted to the adjacent liver segment. Surgery. 2022 10; 172(4):1156-1163. Nishino H, Turner MA, Amirfakhri S, Hollandsworth HM, Lwin TM, Hosseini M, Framery B, Cailler F, Pèlegrin A, Hoffman RM, Bouvet M. PMID: 35927078.
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    113. Long-term Stable Disease in a Rectal-cancer Patient Treated by Methionine Restriction With Oral Recombinant Methioninase and a Low-methionine Diet. Anticancer Res. 2022 Aug; 42(8):3857-3861. Kubota Y, Han Q, Hamada K, Aoki Y, Masaki N, Obara K, Tsunoda T, Hoffman RM. PMID: 35896248.
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    114. Obesity Strongly Promotes Growth of Mouse MC38 Colon Cancer in an Orthotopic-syngeneic C57BL/6 Mouse Model. In Vivo. 2022 Jul-Aug; 36(4):1643-1646. Hamada K, Kubota Y, Aoki Y, Sugisawa N, Yamamoto J, Tashiro Y, Bouvet M, Tsunoda T, Hoffman RM. PMID: 35738603; PMCID: PMC9301442.
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    116. Non-invasively Imageable Tibia-tumor-fragment Implantation Experimental-bone-metastasis Mouse Model of GFP-expressing Prostate Cancer. In Vivo. 2022 Jul-Aug; 36(4):1647-1650. Aoki Y, Masaki N, Tome Y, Kubota Y, Aoki Y, Bouvet M, Nishida K, Hoffman RM. PMID: 35738622; PMCID: PMC9301422.
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    118. Fluorescent Anti-CEA Nanobody for Rapid Tumor-Targeting and Imaging in Mouse Models of Pancreatic Cancer. Biomolecules. 2022 05 16; 12(5). Lwin TM, Turner MA, Nishino H, Amirfakhri S, Hernot S, Hoffman RM, Bouvet M. PMID: 35625638; PMCID: PMC9138244.
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    119. Hair-follicle-associated pluripotent (HAP) stem cells differentiate into mature beating cardiomyocyte sheets on flexible substrates in vitro. Med Mol Morphol. 2022 Sep; 55(3):248-257. Takaoka N, Yamane M, Obara K, Shirai K, Aki R, Hamada Y, Arakawa N, Hoffman RM, Amoh Y. PMID: 35536435.
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    121. Stage IV Pancreatic Cancer Patient Treated With FOLFIRINOX Combined With Oral Methioninase: A Highly-Rare Case With Long-term Stable Disease. Anticancer Res. 2022 May; 42(5):2567-2572. Kubota Y, Han Q, Hozumi C, Masaki N, Yamamoto J, Aoki Y, Tsunoda T, Hoffman RM. PMID: 35489727.
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    122. Guanylate-binding Protein 2 Expression Is Associated With Poor Survival and Malignancy in Clear-cell Renal Cell Carcinoma. Anticancer Res. 2022 May; 42(5):2341-2354. Liu Q, Hoffman RM, Song J, Miao S, Zhang J, Ding D, Wang D. PMID: 35489720.
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    123. ATR inhibition sensitizes liposarcoma to doxorubicin by increasing DNA damage. Am J Cancer Res. 2022; 12(4):1577-1592. Cui J, Dean D, Hornicek FJ, Pollock RE, Hoffman RM, Duan Z. PMID: 35530299; PMCID: PMC9077062.
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    126. Indocyanine Green Labeling of Tumors in the Liver Recurring After Radiofrequency Ablation Enables Complete Resection by Fluorescence-guided Surgery. Anticancer Res. 2022 Mar; 42(3):1345-1350. Tashiro Y, Aoki T, Hirai T, Koizumi T, Kusano T, Matsuda K, Yamada K, Nogaki K, Hakozaki T, Wada Y, Shibata H, Tomioka K, Yamazaki T, Saito K, Fujimori A, Enami Y, Hoffman RM. PMID: 35220226.
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    127. CHFR-Promoter-Methylation Status Is Predictive of Response to Irinotecan-based Systemic Chemotherapy in Advanced Colorectal Cancer. Anticancer Res. 2022 Feb; 42(2):697-707. Hagiwara T, Sugimoto K, Momose H, Irie T, Honjo K, Okazawa YU, Kawai M, Kawano S, Munakata S, Takahashi M, Kojima Y, Serizawa N, Nagahara A, Hoffman RM, Brock MV, Sakamoto K. PMID: 35093868.
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    128. Oral-recombinant Methioninase Converts an Osteosarcoma from Methotrexate-resistant to -sensitive in a Patient-derived Orthotopic-xenograft (PDOX) Mouse Model. Anticancer Res. 2022 Feb; 42(2):731-737. Aoki Y, Tome Y, Han Q, Yamamoto J, Hamada K, Masaki N, Kubota Y, Bouvet M, Nishida K, Hoffman RM. PMID: 35093871.
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    129. High Incidence of Lymph-node Metastasis in a Pancreatic-cancer Patient-derived Orthotopic Xenograft (PDOX) NOG-Mouse Model. Anticancer Res. 2022 Feb; 42(2):739-743. Sugisawa N, Miyake K, Higuchi T, Oshiro H, Park JH, Kawaguchi K, Bouvet M, Unno M, Hoffman RM. PMID: 35093872.
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    130. Methionine Restriction: Ready for Prime Time in the Cancer Clinic? Anticancer Res. 2022 Feb; 42(2):641-644. Yamamoto J, Han Q, Simon M, Thomas D, Hoffman RM. PMID: 35093861.
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    131. Chronic spinal cord injury functionally repaired by direct implantation of encapsulated hair-follicle-associated pluripotent (HAP) stem cells in a mouse model: Potential for clinical regenerative medicine. PLoS One. 2022; 17(1):e0262755. Obara K, Shirai K, Hamada Y, Arakawa N, Yamane M, Takaoka N, Aki R, Hoffman RM, Amoh Y. PMID: 35085322; PMCID: PMC8794105.
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    132. Fluorescence Molecular Targeting of Colon Cancer to Visualize the Invisible. Cells. 2022 01 12; 11(2). Lwin TM, Turner MA, Amirfakhri S, Nishino H, Hoffman RM, Bouvet M. PMID: 35053365; PMCID: PMC8773892.
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    133. Andrographolide, a diterpene lactone from the Traditional Chinese Medicine Andrographis paniculate, induces senescence in human lung adenocarcinoma via p53/p21 and Skp2/p27. Phytomedicine. 2022 Apr; 98:153933. Zhang J, Li C, Zhang L, Heng Y, Wang S, Pan Y, Cai L, Zhang Y, Xu T, Chen X, Hoffman RM, Jia L. PMID: 35121394.
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    135. Determinative Structural Features Identified With Probe-based Confocal Endomicroscopy for the Accurate Diagnosis of Gallbladder Malignancy. Anticancer Res. 2022 Jan; 42(1):67-73. Koizumi T, Aoki T, Yamochi T, Tashiro Y, Yamazaki T, Kusano T, Matsuda K, Wada Y, Shibata H, Saito K, Nogaki K, Hakozaki T, Tomioka K, Hirai T, Fujimori A, Mansour DA, Abbas Gahin AE, Hoffman RM. PMID: 34969710.
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    136. Extent and Instability of Trimethylation of Histone H3 Lysine Increases With Degree of Malignancy and Methionine Addiction. Cancer Genomics Proteomics. 2022 Jan-Feb; 19(1):12-18. Yamamoto J, Aoki Y, Inubushi S, Han Q, Hamada K, Tashiro Y, Miyake K, Matsuyama R, Bouvet M, Clarke SG, Endo I, Hoffman RM. PMID: 34949655; PMCID: PMC8717956.
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    137. The cancer-inhibitory effects of proliferating tumor-residing fibroblasts. Biochim Biophys Acta Rev Cancer. 2022 01; 1877(1):188673. Delinassios JG, Hoffman RM. PMID: 34953931.
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    138. The Use of Fluorescent Anti-CEA Antibodies to Label, Resect and Treat Cancers: A Review. Biomolecules. 2021 Dec 02; 11(12). Turner MA, Lwin TM, Amirfakhri S, Nishino H, Hoffman RM, Yazaki PJ, Bouvet M. PMID: 34944463; PMCID: PMC8699160.
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    139. Osteosarcoma Patient-derived Orthotopic Xenograft (PDOX) Models Used to Identify Novel and Effective Therapeutics: A Review. Anticancer Res. 2021 Dec; 41(12):5865-5871. Higuchi T, Igarashi K, Yamamoto N, Hayashi K, Kimura H, Miwa S, Bouvet M, Tsuchiya H, Hoffman RM. PMID: 34848441.
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    140. A Case of Rare Matrix-producing Triple-negative Breast Carcinoma for Which Drug Response in a Patient-derived Orthotopic Xenograft Mouse Model Was Correlated With Patient Response. Anticancer Res. 2021 Dec; 41(12):6191-6197. Nomura T, Kurebayashi J, Moriya T, Saito W, Murata T, Yamamoto J, Hozumi C, Hoffman RM. PMID: 34848473.
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    141. Histone H3 lysine-trimethylation markers are decreased by recombinant methioninase and increased by methotrexate at concentrations which inhibit methionine-addicted osteosarcoma cell proliferation. Biochem Biophys Rep. 2021 Dec; 28:101177. Aoki Y, Tome Y, Han Q, Yamamoto J, Hamada K, Masaki N, Bouvet M, Nishida K, Hoffman RM. PMID: 34877414; PMCID: PMC8633566.
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    142. Survival Response of Patients With Gastric Cancer Treated With Regional Arterial-Perfusion Chemotherapy Is Correlated With Borrmann Classification. Anticancer Res. 2021 Nov; 41(11):5507-5515. Ma YE, Liang X, Liu LI, Gao D, Yang T, Hoffman RM, Xu J. PMID: 34732421.
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    143. Over-methylation of Histone H3 Lysines Is a Common Molecular Change Among the Three Major Types of Soft-tissue Sarcoma in Patient-derived Xenograft (PDX) Mouse Models. Cancer Genomics Proteomics. 2021 Nov-Dec; 18(6):715-721. Aoki Y, Yamamoto J, Tome Y, Hamada K, Masaki N, Inubushi S, Tashiro Y, Bouvet M, Endo I, Nishida K, Hoffman RM. PMID: 34697064; PMCID: PMC8569816.
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    144. Salmonella typhimurium A1-R Exquisitely Targets and Arrests a Matrix-producing Triple-negative Breast Carcinoma in a PDOX Model. In Vivo. 2021 Nov-Dec; 35(6):3067-3071. Hamada K, Aoki Y, Yamamoto J, Hozumi C, Zhao M, Murata T, Sugisawa N, Bouvet M, Tsunoda T, Hoffman RM. PMID: 34697138; PMCID: PMC8627766.
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    145. Osteosarcoma of the Breast in a Patient Derived Orthotopic Xenograft (PDOX) Mouse Model Is Arrested by both Cisplatinum and Eribulin. In Vivo. 2021 Nov-Dec; 35(6):3107-3110. Masaki N, Wu NF, Aoki Y, Yamamoto J, Miyazaki J, Hoffman RM. PMID: 34697141; PMCID: PMC8627742.
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    146. Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19. Nat Commun. 2021 10 18; 12(1):6055. Boras B, Jones RM, Anson BJ, Arenson D, Aschenbrenner L, Bakowski MA, Beutler N, Binder J, Chen E, Eng H, Hammond H, Hammond J, Haupt RE, Hoffman R, Kadar EP, Kania R, Kimoto E, Kirkpatrick MG, Lanyon L, Lendy EK, Lillis JR, Logue J, Luthra SA, Ma C, Mason SW, McGrath ME, Noell S, Obach RS, O' Brien MN, O'Connor R, Ogilvie K, Owen D, Pettersson M, Reese MR, Rogers TF, Rosales R, Rossulek MI, Sathish JG, Shirai N, Steppan C, Ticehurst M, Updyke LW, Weston S, Zhu Y, White KM, García-Sastre A, Wang J, Chatterjee AK, Mesecar AD, Frieman MB, Anderson AS, Allerton C. PMID: 34663813; PMCID: PMC8523698.
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    147. The Combination of Cisplatinum and Doxorubicin Regressed Primary Osteosarcoma of the Breast in a PDOX Mouse Model. Anticancer Res. 2021 Oct; 41(10):4715-4718. Wu NF, Yamamoto J, Aoki Y, Masaki N, Samonte C, Wu J, Bouvet M, Hoffman RM. PMID: 34593419.
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    148. Antibiotic Usage Reduced Overall Survival by over 70% in Non-small Cell Lung Cancer Patients on Anti-PD-1 Immunotherapy. Anticancer Res. 2021 Oct; 41(10):4985-4993. Hamada K, Yoshimura K, Hirasawa Y, Hosonuma M, Murayama M, Narikawa Y, Ariizumi H, Ohkuma R, Shida M, Kubota Y, Matsukuma S, Ishiguro T, Sambe T, Horiike A, Kuramasu A, Wada S, Tsurutani J, Inoue E, Uchida N, Kiuchi Y, Kobayashi S, Hoffman RM, Tsunoda T. PMID: 34593446.
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    149. Anti-inflammatory and Anti-thrombotic Efficacy of Targeted Ultrasound Microbubbles on LPS-induced HUVEC Cells. Anticancer Res. 2021 Oct; 41(10):4761-4769. Sun J, Pan S, Yu H, Hu H, Sun YU, Yang Z, Hoffman RM, Yuan H. PMID: 34593425.
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    151. Multikinase-Inhibitor Screening in Drug-resistant Osteosarcoma Patient-derived Orthotopic Xenograft Mouse Models Identifies the Clinical Potential of Regorafenib. Cancer Genomics Proteomics. 2021 Sep-Oct; 18(5):637-643. Higuchi T, Igarashi K, Yamamoto N, Hayashi K, Kimura H, Miwa S, Bouvet M, Tsuchiya H, Hoffman RM. PMID: 34479916; PMCID: PMC8441758.
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    152. Five-day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers without toxicity in a clinical trial of normal-weight individuals. Clin Transl Med. 2021 08; 11(8):e502. Jiang Y, Yang X, Dong C, Lu Y, Yin H, Xiao B, Yang X, Chen W, Cheng W, Tian H, Guo L, Hu X, Fang H, Chen W, Li Z, Zhou W, Sun W, Guo X, Li S, Lin Y, He R, Chen X, Liu D, Zhang M, Zhang Y, Zhao H, Zheng P, Seyfried TN, Hoffman RM, Jia W, Ji G, Jia L. PMID: 34459130; PMCID: PMC8320652.
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    153. Indocyanine Green Fluorescence Image-guided Laparoscopic Hepatectomy Enabled Resection of a Tumor Invisible With Ultrasonography. Anticancer Res. 2021 Aug; 41(8):3867-3869. Oura K, Aoki T, Tashiro Y, Matsuda K, Koizumi T, Kusano T, Wada Y, Shibata H, Yamashita T, Date H, Ariyoshi T, Goto S, Yamazaki K, Watanabe M, Fujimori A, Enami Y, Otsuka K, Hoffman RM, Murakami M. PMID: 34281847.
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    154. Rapid tumor-labeling kinetics with a site-specific near-infrared anti-CEA nanobody in a patient-derived orthotopic xenograft mouse model of colon cancer. J Surg Oncol. 2021 Dec; 124(7):1121-1127. Lwin TM, Turner MA, Amirfakhri S, Nishino H, Debie P, Cosman BC, Hoffman RM, Hernot S, Bouvet M. PMID: 34309885; PMCID: PMC8556245.
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    155. Combination of CDK4/6 and mTOR Inhibitors Suppressed Doxorubicin-resistant Osteosarcoma in a Patient-derived Orthotopic Xenograft Mouse Model: A Translatable Strategy for Recalcitrant Disease. Anticancer Res. 2021 Jul; 41(7):3287-3292. Oshiro H, Tome Y, Miyake K, Higuchi T, Sugisawa N, Kanaya F, Nishida K, Hoffman RM. PMID: 34230123.
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    156. Traditional Chinese Medicine Xihuang Wan Inhibited Lewis Lung Carcinoma in a Syngeneic Model, Equivalent to Cytotoxic Chemotherapy, by Altering Multiple Signaling Pathways. In Vivo. 2021 Jul-Aug; 35(4):2005-2014. Zhang Z, Wang J, Duan H, Liu D, Zhou X, Lin X, Pang H, Sun M, Zhou T, Hoffman RM, Hu K. PMID: 34182475; PMCID: PMC8286502.
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    157. Chronic Treatment of an Advanced Prostate-cancer Patient With Oral Methioninase Resulted in Long-term Stabilization of Rapidly Rising PSA Levels. In Vivo. 2021 Jul-Aug; 35(4):2171-2176. Han Q, Hoffman RM. PMID: 34182494; PMCID: PMC8286516.
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    158. The First Mouse Model of Primary Osteosarcoma of the Breast. In Vivo. 2021 Jul-Aug; 35(4):1979-1983. Wu NF, Wu J, Yamamoto J, Aoki Y, Hozumi C, Bouvet M, Hoffman RM. PMID: 34182472; PMCID: PMC8286515.
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    159. A Patient-Derived Orthotopic Xenograft Model of Gastroesophageal-Junction Adenocarcinoma Translated to the Clinic by Tumor-Targeting Fluorescent Antibodies to Carcinoembryonic-Antigen-Related Cell-Adhesion Molecules. In Vivo. 2021 Jul-Aug; 35(4):1959-1963. Turner MA, Amirfakhri S, Nishino H, Lwin TM, Savides TJ, Reid TR, Singer BB, Hoffman RM, Bouvet M. PMID: 34182469; PMCID: PMC8286470.
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    160. Immuno-hyperthermia effected by antibody-conjugated nanoparticles selectively targets and eradicates individual cancer cells. Cell Cycle. 2021 07; 20(13):1221-1230. Kagawa T, Matsumi Y, Aono H, Ohara T, Tazawa H, Shigeyasu K, Yano S, Takeda S, Komatsu Y, Hoffman RM, Fujiwara T, Kishimoto H. PMID: 34148497; PMCID: PMC8330994.
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    161. Effective Tumor Targeting by EphA2-Agonist-Biotin-Streptavidin Conjugates. Molecules. 2021 Jun 17; 26(12). Udompholkul P, Baggio C, Gambini L, Sun Y, Zhao M, Hoffman RM, Pellecchia M. PMID: 34204178; PMCID: PMC8235110.
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    162. Fangchinoline Inhibits Human Esophageal Cancer by Transactivating ATF4 to Trigger Both Noxa-Dependent Intrinsic and DR5-Dependent Extrinsic Apoptosis. Front Oncol. 2021; 11:666549. Zhang Y, Wang S, Chen Y, Zhang J, Yang J, Xian J, Li L, Zhao H, Hoffman RM, Zhang Y, Jia L. PMID: 34195076; PMCID: PMC8236818.
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    164. Neddylation Regulates Macrophages and Implications for Cancer Therapy. Front Cell Dev Biol. 2021; 9:681186. Jiang Y, Li L, Li Y, Liu G, Hoffman RM, Jia L. PMID: 34164400; PMCID: PMC8215544.
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    165. Exosome Transfer Between Pancreatic-cancer Cells Is Associated With Metastasis in a Nude-mouse Model. Anticancer Res. 2021 Jun; 41(6):2829-2834. Ichikawa H, Suetsugu A, Satake T, Aoki H, Kunisada T, Shimizu M, Hoffman RM. PMID: 34083272.
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    166. Traditional Chinese Medicine Brucea Javanica Oil Enhances the Efficacy of Anlotinib in a Mouse Model of Liver-Metastasis of Small-cell Lung Cancer. In Vivo. 2021 May-Jun; 35(3):1437-1441. Peng S, Dong W, Chu Q, Meng J, Yang H, DU Y, Sun YU, Hoffman RM. PMID: 33910820; PMCID: PMC8193324.
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    167. Efficacy of YAP1-gene Knockdown to Inhibit Alveolar-Epithelial-Cell Senescence and Alleviate Idiopathic Pulmonary Fibrosis (IPF). Cancer Genomics Proteomics. 2021 May-Jun; 18(3 Suppl):451-459. Xu W, Song W, Wang YU, Zan Y, Zhang M, Li M, Huang Q, Zhao W, Sun YU, Hoffman RM, Wu J. PMID: 33994367; PMCID: PMC8240039.
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    168. Andrographolide Induces Noxa-Dependent Apoptosis by Transactivating ATF4 in Human Lung Adenocarcinoma Cells. Front Pharmacol. 2021; 12:680589. Zhang J, Li C, Zhang L, Heng Y, Xu T, Zhang Y, Chen X, Hoffman RM, Jia L. PMID: 33995110; PMCID: PMC8117100.
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    170. Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Can Extensively Differentiate to Tyrosine-Hydroxylase-Expressing Dopamine-Secreting Neurons. Cells. 2021 04 10; 10(4). Yamane M, Takaoka N, Obara K, Shirai K, Aki R, Hamada Y, Arakawa N, Hoffman RM, Amoh Y. PMID: 33920157; PMCID: PMC8069047.
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    171. A Novel Color-Coded Liver Metastasis Mouse Model to Distinguish Tumor and Adjacent Liver Segment. J Surg Res. 2021 08; 264:327-333. Nishino H, Hollandsworth HM, Amirfakhri S, Tashiro Y, Yamamoto J, Turner MA, Lwin TM, Singer BB, Hoffman RM, Bouvet M. PMID: 33848831; PMCID: PMC8222089.
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    173. Eribulin Inhibits Osteosarcoma in a Clinically-accurate Bone-tumor-insertion PDOX Mouse Model. Anticancer Res. 2021 Apr; 41(4):1779-1784. Wu NF, Yamamoto J, Aoki Y, Bouvet M, Hoffman RM. PMID: 33813382.
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    174. Lowering and Stabilizing PSA Levels in Advanced-prostate Cancer Patients With Oral Methioninase. Anticancer Res. 2021 Apr; 41(4):1921-1926. Han Q, Hoffman RM. PMID: 33813397.
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    176. Overexpressed NEDD8 as a potential therapeutic target in esophageal squamous cell carcinoma. Cancer Biol Med. 2021 Mar 18. Xian J, Wang S, Jiang Y, Li L, Cai L, Chen P, Liu Y, Zeng X, Chen G, Ding C, Hoffman RM, Jia L, Zhao H, Zhang Y. PMID: 33733647; PMCID: PMC9088192.
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    177. The Experience of Greece as a Model to Contain COVID-19 Infection Spread. In Vivo. 2021 Mar-Apr; 35(2):1285-1294. Delinasios GJ, Fragkou PC, Gkirmpa AM, Tsangaris G, Hoffman RM, Anagnostopoulos AK. PMID: 33622932; PMCID: PMC8045105.
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    178. Combination Methionine-methylation-axis Blockade: A Novel Approach to Target the Methionine Addiction of Cancer. Cancer Genomics Proteomics. 2021 Mar-Apr; 18(2):113-120. Higuchi T, Han Q, Sugisawa N, Yamamoto J, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 33608308; PMCID: PMC7943212.
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    179. The Anti-oxidant Monoterpene p-Cymene Reduced the Occurrence of Colorectal Cancer in a Hyperlipidemia Rat Model by Reducing Oxidative Stress and Expression of Inflammatory Cytokines. Anticancer Res. 2021 Mar; 41(3):1213-1218. Wang S, Wang X, Wang YU, Leng Q, Sun YU, Hoffman RM, Jin H. PMID: 33788712.
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    180. Unique Benefits of Tumor-Specific Nanobodies for Fluorescence Guided Surgery. Biomolecules. 2021 02 18; 11(2). Lwin TM, Hoffman RM, Bouvet M. PMID: 33670740; PMCID: PMC7921980.
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    181. A Novel Orthotopic Mouse Model of Lung Metastasis Using Fluorescent Patient-derived Osteosarcoma Cells. Anticancer Res. 2021 Feb; 41(2):635-640. Oshiro H, Tome Y, Miyake K, Higuchi T, Sugisawa N, Park JH, Zhang Z, Razmjooei S, Kanaya F, Nishida K, Hoffman RM. PMID: 33517267.
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    182. Reversion from Methionine Addiction to Methionine Independence Results in Loss of Tumorigenic Potential of Highly-malignant Lung-cancer Cells. Anticancer Res. 2021 Feb; 41(2):641-643. Yamamoto J, Aoki Y, Han Q, Sugisawa N, Sun YU, Hamada K, Nishino H, Inubushi S, Miyake K, Matsuyama R, Bouvet M, Endo I, Hoffman RM. PMID: 33517268.
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    183. Real-Time Fluorescence Image-Guided Oncolytic Virotherapy for Precise Cancer Treatment. Int J Mol Sci. 2021 Jan 17; 22(2). Yano S, Tazawa H, Kishimoto H, Kagawa S, Fujiwara T, Hoffman RM. PMID: 33477279; PMCID: PMC7830621.
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    184. Color-Coded Imaging of the Tumor Microenvironment (TME) in Human Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models. Adv Exp Med Biol. 2021; 1329:163-179. Suetsugu A, Hoffman RM. PMID: 34664239.
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    185. A Novel Procedure for Orthotopic Tibia Implantation for Establishment of a More Clinical Osteosarcoma PDOX Mouse Model. In Vivo. 2021 Jan-Feb; 35(1):105-109. Wu NF, Yamamoto J, Bouvet M, Hoffman RM. PMID: 33402455; PMCID: PMC7880751.
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    186. Color-Coded Imaging of Cancer and Stromal-Cell Interaction in the Pancreatic-Cancer Tumor Microenvironment (TME). Methods Mol Biol. 2021; 2224:99-111. Suetsugu A, Hoffman RM. PMID: 33606209.
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    187. Triple-Methyl Blockade With Recombinant Methioninase, Cycloleucine, and Azacitidine Arrests a Pancreatic Cancer Patient-Derived Orthotopic Xenograft Model. Pancreas. 2021 01 01; 50(1):93-98. Sugisawa N, Yamamoto J, Han Q, Tan Y, Tashiro Y, Nishino H, Inubushi S, Hamada K, Kawaguchi K, Unno M, Bouvet M, Hoffman RM. PMID: 33370029.
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    188. A Universal Gelfoam 3-D Histoculture Method to Establish Patient-derived Cancer Cells (3D-PDCC) Without Fibroblasts from Patient-derived Xenografts. Anticancer Res. 2020 Dec; 40(12):6765-6768. Yamamoto J, Sugisawa N, Hamada K, Nishino H, Miyake K, Matsuyama R, Inubushi S, Tanino H, Bouvet M, Endo I, Hoffman RM. PMID: 33288569.
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    189. A review of tumor-specific fluorescence-guided surgery for colorectal cancer. Surg Oncol. 2021 Mar; 36:84-90. Hollandsworth HM, Turner MA, Hoffman RM, Bouvet M. PMID: 33316684; PMCID: PMC7855598.
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    190. A novel patient-derived orthotopic xenograft (PDOX) mouse model of highly-aggressive liver metastasis for identification of candidate effective drug-combinations. Sci Rep. 2020 11 18; 10(1):20105. Zhang Z, Hu K, Miyake K, Kiyuna T, Oshiro H, Wangsiricharoen S, Kawaguchi K, Higuchi T, Razmjooei S, Miyake M, Chawla SP, Singh SR, Hoffman RM. PMID: 33208807; PMCID: PMC7676248.
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    191. Sutureless Surgical Orthotopic Implantation Technique of Primary and Metastatic Cancer in the Liver of Mouse Models. In Vivo. 2020 Nov-Dec; 34(6):3153-3157. Nishino H, Hollandsworth HM, Sugisawa N, Yamamoto J, Tashiro Y, Inubushi S, Hamada K, Sun YU, Lim H, Amirfakhri S, Filemoni F, Hoffman RM, Bouvet M. PMID: 33144418; PMCID: PMC7811661.
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    192. Ligation Method to Specifically Label a Liver Segment With Indocyanine Green in an Orthotopic Nude-Mouse Liver-Metastasis Model. In Vivo. 2020 Nov-Dec; 34(6):3159-3162. Nishino H, Hollandsworth HM, Tashiro Y, Yamamoto J, Amirfakhri S, Filemoni F, Sugisawa N, Hoffman RM, Bouvet M. PMID: 33144419; PMCID: PMC7811678.
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    193. Response of Triple-negative Breast Cancer Liver Metastasis to Oral Recombinant Methioninase in a Patient-derived Orthotopic Xenograft (PDOX) Model. In Vivo. 2020 Nov-Dec; 34(6):3163-3169. Lim HI, Yamamoto J, Han Q, Sun YU, Nishino H, Tashiro Y, Sugisawa N, Tan Y, Choi HJ, Nam SJ, Bouvet M, Hoffman RM. PMID: 33144420; PMCID: PMC7811664.
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    194. A Non-invasive Imageable GFP-expressing Mouse Model of Orthotopic Human Bladder Cancer. In Vivo. 2020 Nov-Dec; 34(6):3225-3231. Sun YU, Nishino H, Zhao M, Miyake K, Sugisawa N, Yamamoto J, Tashiro Y, Inubushi S, Hamada K, Zhu G, Lim H, Hoffman RM. PMID: 33144427; PMCID: PMC7811621.
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    195. Co-implantation of Tumor and Extensive Surrounding Tissue Improved the Establishment Rate of Surgical Specimens of Human-Patient Cancer in Nude Mice: Toward the Goal of Universal Individualized Cancer Therapy. In Vivo. 2020 Nov-Dec; 34(6):3241-3245. Murata T, Hozumi C, Hiroshima Y, Shimoya K, Hongo A, Inubushi S, Tanino H, Hoffman RM. PMID: 33144429; PMCID: PMC7811650.
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    196. Oral Recombinant Methioninase Sensitizes a Bladder Cancer Orthotopic Xenograft Mouse Model to Low-dose Cisplatinum and Prevents Metastasis. Anticancer Res. 2020 Nov; 40(11):6083-6091. Sun YU, Nishino H, Sugisawa N, Yamamoto J, Hamada K, Zhu G, Lim HI, Hoffman RM. PMID: 33109546.
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    197. Ischemia reperfusion-induced metastasis is resistant to PPARγ agonist pioglitazone in a murine model of colon cancer. Sci Rep. 2020 10 29; 10(1):18565. Tashiro Y, Nishino H, Higuchi T, Sugisawa N, Fukuda Y, Yamamoto J, Inubushi S, Aoki T, Murakami M, Singh SR, Bouvet M, Hoffman RM. PMID: 33122687; PMCID: PMC7596558.
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    198. Histone methylation status of H3K4me3 and H3K9me3 under methionine restriction is unstable in methionine-addicted cancer cells, but stable in normal cells. Biochem Biophys Res Commun. 2020 12 17; 533(4):1034-1038. Yamamoto J, Han Q, Inubushi S, Sugisawa N, Hamada K, Nishino H, Miyake K, Kumamoto T, Matsuyama R, Bouvet M, Endo I, Hoffman RM. PMID: 33019978.
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    199. Prostate Cancer Metastases Are Strongly Inhibited by Agonistic Epha2 Ligands in an Orthotopic Mouse Model. Cancers (Basel). 2020 Oct 02; 12(10). Salem AF, Gambini L, Billet S, Sun Y, Oshiro H, Zhao M, Hoffman RM, Bhowmick NA, Pellecchia M. PMID: 33023262; PMCID: PMC7600344.
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    200. A Gemcitabine Plus 5-Fluorouracil Combination Inhibits Gastric-Cancer Liver Metastasis in a PDOX Model: A Novel Treatment Strategy. Anticancer Res. 2020 Oct; 40(10):5393-5397. Sugisawa N, Nishino H, Higuchi T, Park JH, Yamamoto J, Tashiro Y, Kawaguchi K, Bouvet M, Unno M, Hoffman RM. PMID: 32988858.
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    201. Fluorescence-guided hepatobiliary surgery with long and short wavelength fluorophores. Hepatobiliary Surg Nutr. 2020 Oct; 9(5):615-639. Lwin TM, Hoffman RM, Bouvet M. PMID: 33163512; PMCID: PMC7603922.
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    202. FUCCI Real-Time Cell-Cycle Imaging as a Guide for Designing Improved Cancer Therapy: A Review of Innovative Strategies to Target Quiescent Chemo-Resistant Cancer Cells. Cancers (Basel). 2020 Sep 17; 12(9). Yano S, Tazawa H, Kagawa S, Fujiwara T, Hoffman RM. PMID: 32957652; PMCID: PMC7563319.
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    203. Adjuvant Oral Recombinant Methioninase Inhibits Lung Metastasis in a Surgical Breast-Cancer Orthotopic Syngeneic Model. Anticancer Res. 2020 Sep; 40(9):4869-4874. Sugisawa N, Hamada K, Han Q, Yamamoto J, Sun YU, Nishino H, Kawaguchi K, Bouvet M, Unno M, Hoffman RM. PMID: 32878774.
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    204. Brucea javanica Increases Survival and Enhances Gemcitabine Efficacy in a Patient-derived Orthotopic Xenograft (PDOX) Mouse Model of Pancreatic Cancer. Anticancer Res. 2020 Sep; 40(9):4969-4978. Yang H, Tong Z, Shen L, Sun YU, Hoffman RM, Huang J. PMID: 32878785.
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    205. Indocyanine Green Labels an Orthotopic Nude-Mouse Model of Very-Early Colon-Cancer Liver Metastases. In Vivo. 2020 Sep-Oct; 34(5):2277-2280. Tashiro Y, Hollandsworth HM, Nishino H, Yamamoto J, Amirfakhri S, Filemoni F, Sugisawa N, Aoki T, Murakami M, Hoffman RM, Bouvet M. PMID: 32871750; PMCID: PMC7652533.
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    206. Oral Methioninase Inhibits Recurrence in a PDOX Mouse Model of Aggressive Triple-negative Breast Cancer. In Vivo. 2020 Sep-Oct; 34(5):2281-2286. Lim HI, Hamada K, Yamamoto J, Han Q, Tan Y, Choi HJ, Nam SJ, Bouvet M, Hoffman RM. PMID: 32871751; PMCID: PMC7652477.
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    207. Humanized Fluorescent Tumor-associated Glycoprotein-72 Antibody Selectively Labels Colon-cancer Liver Metastases in Orthotopic Mouse Models. In Vivo. 2020 Sep-Oct; 34(5):2303-2307. Hollandsworth HM, Nishino H, Turner M, Amirfakhri S, Filemoni F, Hoffman RM, Yazaki PJ, Bouvet M. PMID: 32871754; PMCID: PMC7652487.
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    208. An Improved Encapsulation Method for Cryopreserving Hepatocytes for Functional Transplantation Using a Thermo-reversible Gelation Polymer. In Vivo. 2020 Sep-Oct; 34(5):2309-2316. Yamada K, Aoki T, Enami Y, Tashiro Y, Zehaou Z, Koizumi T, Kusano T, Matsuda K, Wada Y, Shibata H, Tomioka K, Siriratsivawong K, Hoffman RM, Murakami M. PMID: 32871755; PMCID: PMC7652459.
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    209. Fluorophore-conjugated Helicobacter pylori recombinant membrane protein (HopQ) labels primary colon cancer and metastases in orthotopic mouse models by binding CEA-related cell adhesion molecules. Transl Oncol. 2020 Dec; 13(12):100857. Hollandsworth HM, Schmitt V, Amirfakhri S, Filemoni F, Schmidt A, Landström M, Lyndin M, Backert S, Gerhard M, Wennemuth G, Hoffman RM, Singer BB, Bouvet M. PMID: 32866936; PMCID: PMC7475271.
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    210. Oral recombinant methioninase increases TRAIL receptor-2 expression to regress pancreatic cancer in combination with agonist tigatuzumab in an orthotopic mouse model. Cancer Lett. 2020 11 01; 492:174-184. Yamamoto J, Miyake K, Han Q, Tan Y, Inubushi S, Sugisawa N, Higuchi T, Tashiro Y, Nishino H, Homma Y, Matsuyama R, Chawla SP, Bouvet M, Singh SR, Endo I, Hoffman RM. PMID: 32739322.
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    211. The identification of candidate effective combination regimens for pancreatic cancer using the histoculture drug response assay. Sci Rep. 2020 07 20; 10(1):12004. Jun E, Park Y, Lee W, Kwon J, Lee S, Kim MB, Lee JS, Song KB, Hwang DW, Lee JH, Hoffman RM, Kim SC. PMID: 32686712; PMCID: PMC7371642.
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    212. NEDD8-conjugating enzyme UBC12 as a novel therapeutic target in esophageal squamous cell carcinoma. Signal Transduct Target Ther. 2020 07 10; 5(1):123. Wang S, Xian J, Li L, Jiang Y, Liu Y, Cai L, Hoffman RM, Jia L, Zhao H, Zhang Y. PMID: 32651357; PMCID: PMC7351728.
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    213. Osimertinib regressed an EGFR-mutant lung-adenocarcinoma bone-metastasis mouse model and increased long-term survival. Transl Oncol. 2020 Oct; 13(10):100826. Higuchi T, Sugisawa N, Park JH, Sun Y, Zhu G, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 32659740; PMCID: PMC7356269.
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    214. Eribulin Regresses a Doxorubicin-resistant Dedifferentiated Liposarcoma in a Patient-derived Orthotopic Xenograft Mouse Model. Cancer Genomics Proteomics. 2020 Jul-Aug; 17(4):351-358. Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Higuchi T, Yamamoto N, Hayashi K, Kimura H, Miwa S, Singh SR, Tsuchiya H, Hoffman RM. PMID: 32576580; PMCID: PMC7367606.
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    215. Pathological Validity of Using Near-infrared Fluorescence Imaging for Securing Surgical Margins During Liver Resection. Anticancer Res. 2020 Jul; 40(7):3873-3882. Tashiro Y, Aoki T, Hirai T, Koizumi T, Mansou DA, Kusano T, Matsuda K, Yamada K, Nogaki K, Hakozaki T, Wada Y, Shibata H, Tomioka K, Yamazaki T, Saito K, Fujimori A, Enami Y, Hoffman RM, Murakami M. PMID: 32620627.
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    216. Near-infrared photoimmunotherapy is effective treatment for colorectal cancer in orthotopic nude-mouse models. PLoS One. 2020; 15(6):e0234643. Hollandsworth HM, Amirfakhri S, Filemoni F, Molnar J, Hoffman RM, Yazaki P, Bouvet M. PMID: 32555717; PMCID: PMC7302706.
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    217. Oral Methioninase for Covid-19 Methionine-restriction Therapy. In Vivo. 2020 Jun; 34(3 Suppl):1593-1596. Hoffman RM, Han Q. PMID: 32503816; PMCID: PMC8378026.
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    218. Oncogenic miRNAs Identified in Tear Exosomes From Metastatic Breast Cancer Patients. Anticancer Res. 2020 06; 40(6):3091-3096. Inubushi S, Kawaguchi H, Mizumoto S, Kunihisa T, Baba M, Kitayama Y, Takeuchi T, Hoffman RM, Sasaki R. PMID: 32487603.
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    219. The future of tumour-specific fluorescence-guided surgery for pancreatic cancer. Lancet Gastroenterol Hepatol. 2020 08; 5(8):715-717. Lwin TM, Hoffman RM, Bouvet M. PMID: 32416765; PMCID: PMC11057912.
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    220. Myc is a prognostic biomarker and potential therapeutic target in osteosarcoma. Ther Adv Med Oncol. 2020; 12:1758835920922055. Feng W, Dean DC, Hornicek FJ, Spentzos D, Hoffman RM, Shi H, Duan Z. PMID: 32426053; PMCID: PMC7222246.
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    222. A Novel Anionic-phosphate-platinum Complex Effectively Targets a Cisplatinum-resistant Osteosarcoma in a Patient-derived Orthotopic Xenograft Mouse Model. Cancer Genomics Proteomics. 2020 May-Jun; 17(3):217-223. Igarashi K, Kawaguchi K, Yamamoto N, Hayashi K, Kimura H, Miwa S, Higuchi T, Taniguchi Y, Yonezawa H, Araki Y, Morinaga S, Misra S, Nelson SD, Dry SM, Li Y, Odani A, Singh SR, Tsuchiya H, Hoffman RM. PMID: 32345663; PMCID: PMC7259888.
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    223. Recombinant Methioninase Combined With Tumor-targeting Salmonella typhimurium A1-R Induced Regression in a PDOX Mouse Model of Doxorubicin-resistant Dedifferentiated Liposarcoma. Anticancer Res. 2020 May; 40(5):2515-2523. Igarashi K, Kawaguchi K, Zhao M, Han Q, Tan Y, Kiyuna T, Miyake K, Higuchi T, Nelson SD, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Singh SR, Tsuchiya H, Hoffman RM. PMID: 32366396.
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    224. Oral dosing of Recombinant Methioninase Is Associated With a 70% Drop in PSA in a Patient With Bone-metastatic Prostate Cancer and 50% Reduction in Circulating Methionine in a High-stage Ovarian Cancer Patient. Anticancer Res. 2020 May; 40(5):2813-2819. Han Q, Tan Y, Hoffman RM. PMID: 32366428.
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    225. Oral Recombinant Methioninase Inhibits Diabetes Onset in Mice on a High-fat Diet. In Vivo. 2020 May-Jun; 34(3):973-978. Tashiro Y, Han Q, Tan Y, Sugisawa N, Yamamoto J, Nishino H, Inubushi S, Sun YU, Zhu G, Lim H, Aoki T, Murakami M, Bouvet M, Hoffman RM. PMID: 32354882; PMCID: PMC7279799.
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    226. A Triple-negative Matrix-producing Breast Carcinoma Patient-derived Orthotopic Xenograft (PDOX) Mouse Model Is Sensitive to Bevacizumab and Vinorelbine, Regressed by Eribulin and Resistant to Olaparib. Anticancer Res. 2020 May; 40(5):2509-2514. Yamamoto J, Murata T, Tashiro Y, Higuchi T, Sugisawa N, Nishino H, Inubushi S, Sun YU, Lim H, Miyake K, Hongo A, Nomura T, Saitoh W, Moriya T, Tanino H, Hozumi C, Bouvet M, Singh SR, Endo I, Hoffman RM. PMID: 32366395.
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    227. Comparison of the Efficacy of EGFR Tyrosine Kinase Inhibitors Erlotinib and Low-dose Osimertinib on a PC-9-GFP EGFR Mutant Non-small-cell Lung Cancer Growing in the Brain of Nude Mice. In Vivo. 2020 May-Jun; 34(3):1027-1030. Katsuya Y, Miyake K, Higuchi T, Oshiro H, Sugisawa N, Singh SR, Goto Y, Zhao M, Hoffman RM. PMID: 32354888; PMCID: PMC7279826.
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    228. Eribulin Regresses a Cisplatinum-resistant Rare-type Triple-negative Matrix-producing Breast Carcinoma Patient-derived Orthotopic Xenograft Mouse Model. Anticancer Res. 2020 May; 40(5):2475-2479. Yamamoto J, Murata T, Sugisawa N, Higuchi T, Tashiro Y, Nishino H, Inubushi S, Sun YU, Lim H, Miyake K, Shimoya K, Nomura T, Kurebayashi J, Tanino H, Hozumi C, Bouvet M, Singh SR, Endo I, Hoffman RM. PMID: 32366391.
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    229. Oral Recombinant Methioninase Prevents Nonalcoholic Fatty Liver Disease in Mice on a High Fat Diet. In Vivo. 2020 May-Jun; 34(3):979-984. Tashiro Y, Han Q, Tan Y, Sugisawa N, Yamamoto J, Nishino H, Inubushi S, Sun YU, Lim H, Aoki T, Murakami M, Takahashi Y, Bouvet M, Hoffman RM. PMID: 32354883; PMCID: PMC7279815.
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    230. A Single Low Dose of Eribulin Regressed a Highly Aggressive Triple-negative Breast Cancer in a Patient-derived Orthotopic Xenograft Model. Anticancer Res. 2020 May; 40(5):2481-2485. Lim HI, Yamamoto J, Inubushi S, Nishino H, Tashiro Y, Sugisawa N, Han Q, Sun YU, Choi HJ, Nam SJ, Kim MB, Lee JS, Hozumi C, Bouvet M, Singh SR, Hoffman RM. PMID: 32366392.
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    231. Humanized Anti-Tumor-Associated Glycoprotein-72 for Submillimeter Near-Infrared Detection of Colon Cancer in Metastatic Mouse Models. J Surg Res. 2020 08; 252:16-21. Hollandsworth HM, Amirfakhri S, Filemoni F, Hoffman RM, Molnar J, Yazaki PJ, Bouvet M. PMID: 32217350; PMCID: PMC7295682.
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    232. Temozolomide and Pazopanib Combined with FOLFOX Regressed a Primary Colorectal Cancer in a Patient-derived Orthotopic Xenograft Mouse Model. Transl Oncol. 2020 Mar; 13(3):100739. Zhu G, Zhao M, Han Q, Tan Y, Sun Y, Bouvet M, Clary B, Singh SR, Ye J, Hoffman RM. PMID: 32143177; PMCID: PMC7058405.
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    233. Oral Recombinant Methioninase Prevents Obesity in Mice on a High-fat Diet. In Vivo. 2020 Mar-Apr; 34(2):489-494. Tashiro Y, Han Q, Tan Y, Sugisawa N, Yamamoto J, Nishino H, Inubushi S, Higuchi T, Aoki T, Murakami M, Hoffman RM. PMID: 32111745; PMCID: PMC7157881.
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    234. Pazopanib Inhibits Tumor Growth, Lymph-node Metastasis and Lymphangiogenesis of an Orthotopic Mouse of Colorectal Cancer. Cancer Genomics Proteomics. 2020 Mar-Apr; 17(2):131-139. Zhu G, Zhao M, Han Q, Tan Y, Sun YU, Bouvet M, Singh SR, Ye J, Hoffman RM. PMID: 32108035; PMCID: PMC7078832.
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    235. APELA/ELA32 Reduces Iodixanol-induced Apoptosis, Inflammatory Response and Mitochondrial and DNA Damage in Renal Tubular Epithelial Cells. Anticancer Res. 2020 Feb; 40(2):635-643. Li Y, Huang J, He S, Lu Z, Zhang J, Li X, Yang Z, Hoffman RM, Wu Q. PMID: 32014904.
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    236. Anti-carcinoembryonic antigen-related cell adhesion molecule antibody for fluorescence visualization of primary colon cancer and metastases in patient-derived orthotopic xenograft mouse models. Oncotarget. 2020 Jan 28; 11(4):429-439. Hollandsworth HM, Amirfakhri S, Filemoni F, Schmitt V, Wennemuth G, Schmidt A, Hoffman RM, Singer BB, Bouvet M. PMID: 32064046; PMCID: PMC6996915.
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    237. Effective targeting of the ubiquitin-like modifier NEDD8 for lung adenocarcinoma treatment. Cell Biol Toxicol. 2020 08; 36(4):349-364. Jiang Y, Cheng W, Li L, Zhou L, Liang Y, Zhang W, Chen W, Wang S, Zhao H, Chen G, Zhou W, Ji G, Zhang Y, Hoffman RM, Wang M, Jia L. PMID: 31907687.
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    238. Collective cancer invasion forms an integrin-dependent radioresistant niche. J Exp Med. 2020 01 06; 217(1). Haeger A, Alexander S, Vullings M, Kaiser FMP, Veelken C, Flucke U, Koehl GE, Hirschberg M, Flentje M, Hoffman RM, Geissler EK, Kissler S, Friedl P. PMID: 31658985; PMCID: PMC7037234.
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    239. TRAF6-Mediated Inflammatory Cytokines Secretion in LPS-induced Colorectal Cancer Cells Is Regulated by miR-140. Cancer Genomics Proteomics. 2020 Jan-Feb; 17(1):23-33. Zhu G, Lin C, Cheng Z, Wang Q, Hoffman RM, Singh SR, Huang Y, Zheng W, Yang S, Ye J. PMID: 31882548; PMCID: PMC6937127.
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    240. PPARγ Agonist Pioglitazone in Combination With Cisplatinum Arrests a Chemotherapy-resistant Osteosarcoma PDOX Model. Cancer Genomics Proteomics. 2020 Jan-Feb; 17(1):35-40. Higuchi T, Yamamoto J, Sugisawa N, Tashiro Y, Nishino H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31882549; PMCID: PMC6937125.
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    241. Relevance of Vitamin D in Melanoma Development, Progression and Therapy. Anticancer Res. 2020 Jan; 40(1):473-489. Brozyna AA, Hoffman RM, Slominski AT. PMID: 31892603; PMCID: PMC6948187.
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    242. Exquisite Tumor Targeting by Salmonella A1-R in Combination with Caffeine and Valproic Acid Regresses an Adult Pleomorphic Rhabdomyosarcoma Patient-Derived Orthotopic Xenograft Mouse Model. Transl Oncol. 2020 Feb; 13(2):393-400. Igarashi K, Kawaguchi K, Zhao M, Kiyuna T, Miyake K, Miyake M, Nelson SD, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Higuchi T, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31896528; PMCID: PMC6940643.
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    244. Combination of Trabectedin With Irinotecan, Leucovorin and 5-Fluorouracil Arrests Primary Colorectal Cancer in an Imageable Patient-derived Orthotopic Xenograft Mouse Model. Anticancer Res. 2019 Dec; 39(12):6463-6470. Zhu G, Zhao M, Han Q, Tan Y, Sun YU, Bouvet M, Clary B, Singh SR, Ye J, Hoffman RM. PMID: 31810910.
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    245. The combination of oral-recombinant methioninase and azacitidine arrests a chemotherapy-resistant osteosarcoma patient-derived orthotopic xenograft mouse model. Cancer Chemother Pharmacol. 2020 02; 85(2):285-291. Higuchi T, Sugisawa N, Yamamoto J, Oshiro H, Han Q, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Tan Y, Kuchipudi S, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31705268.
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    246. MyD88 Regulates LPS-induced NF-ĸB/MAPK Cytokines and Promotes Inflammation and Malignancy in Colorectal Cancer Cells. Cancer Genomics Proteomics. 2019 Nov-Dec; 16(6):409-419. Zhu G, Cheng Z, Lin C, Hoffman RM, Huang Y, Singh SR, Zheng W, Yang S, Ye J. PMID: 31659096; PMCID: PMC6885359.
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    247. Double-negative T Cells Inhibit Proliferation and Invasion of Human Pancreatic Cancer Cells in Co-culture. Anticancer Res. 2019 Nov; 39(11):5911-5918. Lu Y, Hu P, Zhou H, Yang Z, Sun YU, Hoffman RM, Chen J. PMID: 31704815.
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    248. Robo1-specific CAR-NK Immunotherapy Enhances Efficacy of 125I Seed Brachytherapy in an Orthotopic Mouse Model of Human Pancreatic Carcinoma. Anticancer Res. 2019 Nov; 39(11):5919-5925. Xia N, Haopeng P, Gong JU, Lu J, Chen Z, Zheng Y, Wang Z, Sun YU, Yang Z, Hoffman RM, Liu F. PMID: 31704816.
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    249. Aurora-A/NF-ĸB Signaling Is Associated With Radio-resistance in Human Lung Adenocarcinoma. Anticancer Res. 2019 Nov; 39(11):5991-5998. Liu JB, Hu L, Yang Z, Sun YU, Hoffman RM, Yi Z. PMID: 31704824.
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    250. Combination of Trabectedin With Oxaliplatinum and 5-Fluorouracil Arrests a Primary Colorectal Cancer in a Patient-derived Orthotopic Xenograft Mouse Model. Anticancer Res. 2019 Nov; 39(11):5999-6005. Zhu G, Zhao M, Han Q, Tan Y, Sun YU, Bouvet M, Singh SR, Ye J, Hoffman RM. PMID: 31704825.
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    251. Novel targets identified by integrated cancer-stromal interactome analysis of pancreatic adenocarcinoma. Cancer Lett. 2020 01 28; 469:217-227. Hiroshima Y, Kasajima R, Kimura Y, Komura D, Ishikawa S, Ichikawa Y, Bouvet M, Yamamoto N, Oshima T, Morinaga S, Singh SR, Hoffman RM, Endo I, Miyagi Y. PMID: 31669204.
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    252. Patient-derived orthotopic xenograft models of sarcoma. Cancer Lett. 2020 01 28; 469:332-339. Igarashi K, Kawaguchi K, Murakami T, Miyake K, Kiyuna T, Miyake M, Hiroshima Y, Higuchi T, Oshiro H, Nelson SD, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31639427.
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    253. Induction of Metastasis by Low-dose Gemcitabine in a Pancreatic Cancer Orthotopic Mouse Model: An Opposite Effect of Chemotherapy. Anticancer Res. 2019 Oct; 39(10):5339-5344. Sugisawa N, Miyake K, Higuchi T, Oshiro H, Zhang Z, Park JH, Kawaguchi K, Chawla SP, Bouvet M, Singh SR, Unno M, Hoffman RM. PMID: 31570427.
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    254. Oral recombinant methioninase combined with oxaliplatinum and 5-fluorouracil regressed a colon cancer growing on the peritoneal surface in a patient-derived orthotopic xenograft mouse model. Tissue Cell. 2019 Dec; 61:109-114. Park JH, Han Q, Zhao M, Tan Y, Higuchi T, Yoon SN, Sugisawa N, Yamamoto J, Bouvet M, Clary B, Singh SR, Hoffman RM. PMID: 31759402.
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    255. AMMECR1 Inhibits Apoptosis and Promotes Cell-cycle Progression and Proliferation of the A549 Human Lung Cancer Cell Line. Anticancer Res. 2019 Sep; 39(9):4637-4642. Ge H, Cheng N, Xu X, Yang Z, Hoffman RM, Zhu J. PMID: 31519561.
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    256. Oral Recombinant Methioninase, Combined With Oral Caffeine and Injected Cisplatinum, Overcome Cisplatinum-Resistance and Regresses Patient-derived Orthotopic Xenograft Model of Osteosarcoma. Anticancer Res. 2019 Sep; 39(9):4653-4657. Higuchi T, Oshiro H, Miyake K, Sugisawa N, Han Q, Tan Y, Park J, Zhang Z, Razmjooei S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Chawla SP, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31519563.
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    257. Oral Recombinant Methioninase Overcomes Colorectal-cancer Liver Metastasis Resistance to the Combination of 5-Fluorouracil and Oxaliplatinum in a Patient-derived Orthotopic Xenograft Mouse Model. Anticancer Res. 2019 Sep; 39(9):4667-4671. Oshiro H, Tome Y, Kiyuna T, Yoon SN, Lwin TM, Han Q, Tan Y, Miyake K, Higuchi T, Sugisawa N, Katsuya Y, Park JH, Zang Z, Razmjooei S, Bouvet M, Clary B, Singh SR, Kanaya F, Nishida K, Hoffman RM. PMID: 31519565.
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    258. Eribulin Suppressed Cisplatinum- and Doxorubicin-resistant Recurrent Lung Metastatic Osteosarcoma in a Patient-derived Orthotopic Xenograft Mouse Model. Anticancer Res. 2019 Sep; 39(9):4775-4779. Kiyuna T, Tome Y, Miyake K, Murakami T, Oshiro H, Igarashi K, Kawaguchi K, Hsu J, Singh M, Li Y, Nelson S, Bouvet M, Singh SR, Kanaya F, Hoffman RM. PMID: 31519578.
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    259. Combination Treatment With Sorafenib and Everolimus Regresses a Doxorubicin-resistant Osteosarcoma in a PDOX Mouse Model. Anticancer Res. 2019 Sep; 39(9):4781-4786. Higuchi T, Sugisawa N, Miyake K, Oshiro H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Kline Z, Belt P, Chawla SP, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31519579.
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    260. Pioglitazone, an agonist of PPARγ, reverses doxorubicin-resistance in an osteosarcoma patient-derived orthotopic xenograft model by downregulating P-glycoprotein expression. Biomed Pharmacother. 2019 Oct; 118:109356. Higuchi T, Sugisawa N, Miyake K, Oshiro H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Kline Z, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31545293.
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    261. Efficacy of oral recombinant methioninase combined with oxaliplatinum and 5-fluorouracil on primary colon cancer in a patient-derived orthotopic xenograft mouse model. Biochem Biophys Res Commun. 2019 10 15; 518(2):306-310. Park JH, Zhao M, Han Q, Sun Y, Higuchi T, Sugisawa N, Yamamoto J, Singh SR, Clary B, Bouvet M, Hoffman RM. PMID: 31421825.
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    262. High-Mobility Group Box 1 expression predicts survival of patients after resection of adenocarcinoma of the ampulla of Vater. World J Surg Oncol. 2019 Aug 09; 17(1):140. Murakami T, Matsuyama R, Ueda M, Mochizuki Y, Homma Y, Kameda K, Yazawa K, Izumisawa Y, Fukushima T, Kamimukai N, Yoshida K, Kamiya N, Hoffman RM, Endo I. PMID: 31399104; PMCID: PMC6689175.
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    263. Color-coded Imaging of the Fate of Cancer-cell-derived Exosomes During Pancreatic Cancer Metastases in a Nude-mouse Model. Anticancer Res. 2019 Aug; 39(8):4055-4060. Satake T, Suetsugu A, Nakamura M, Kunisada T, Saji S, Moriwaki H, Shimizu M, Hoffman RM. PMID: 31366487.
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    264. Choline-deficient-diet Decreases Fibroblasts in the Circulating Tumor Cell (CTC) Microenvironment. Anticancer Res. 2019 Aug; 39(8):4061-4064. Matsuura K, Suetsugu A, Satake T, Nakamura M, Kunisada T, Shimizu M, Hoffman RM. PMID: 31366488.
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    265. Tumor-sealing Surgical Orthotopic Implantation of Human Colon Cancer in Nude Mice Induces Clinically-relevant Metastases Without Early Peritoneal Carcinomatosis. Anticancer Res. 2019 Aug; 39(8):4065-4071. Yoon SN, Park JH, Lwin TM, Miyake K, Singh SR, Hoffman RM, Bouvet M. PMID: 31366489; PMCID: PMC11058567.
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    266. Sorafenib and Palbociclib Combination Regresses a Cisplatinum-resistant Osteosarcoma in a PDOX Mouse Model. Anticancer Res. 2019 Aug; 39(8):4079-4084. Higuchi T, Sugisawa N, Miyake K, Oshiro H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Chawla SP, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31366491.
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    267. The Combination of Olaratumab with Doxorubicin and Cisplatinum Regresses a Chemotherapy-Resistant Osteosarcoma in a Patient-Derived Orthotopic Xenograft Mouse Model. Transl Oncol. 2019 Sep; 12(9):1257-1263. Higuchi T, Sugisawa N, Miyake K, Oshiro H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31299622; PMCID: PMC6624322.
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    268. Peritoneal Metastases in a Patient-derived Orthotopic Xenograft (PDOX) Model of Colon Cancer Imaged Non-invasively via Red Fluorescent Protein Labeled Stromal Cells. Anticancer Res. 2019 Jul; 39(7):3463-3467. Park JH, Zhao M, Oshiro H, Miyake K, Higuchi T, Reynoso J, Razmjooei S, Bouvet M, Clary B, Zhang Z, Sugisawa N, Yamamoto J, Singh SR, Hoffman RM. PMID: 31262870.
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    269. RE: "Intraoperative Near-infrared Imaging Can Identify Neoplasms and Aid in Real-time Margin Assessment During Pancreatic Resection". Ann Surg. 2019 07; 270(1):21-22. Bouvet M, Lwin TM, Hoffman RM. PMID: 31188174.
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    270. Hair-follicle-associated pluripotent stem cells derived from cryopreserved intact human hair follicles sustain multilineage differentiation potential. Sci Rep. 2019 06 27; 9(1):9326. Obara K, Tohgi N, Mii S, Hamada Y, Arakawa N, Aki R, Singh SR, Hoffman RM, Amoh Y. PMID: 31249324; PMCID: PMC6597789.
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    271. Promotion of tumor-associated macrophages infiltration by elevated neddylation pathway via NF-κB-CCL2 signaling in lung cancer. Oncogene. 2019 07; 38(29):5792-5804. Zhou L, Jiang Y, Liu X, Li L, Yang X, Dong C, Liu X, Lin Y, Li Y, Yu J, He R, Huang S, Liu G, Zhang Y, Jeong LS, Hoffman RM, Jia L. PMID: 31243299.
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    273. Efficacy of Tumor-Targeting Salmonella typhimurium A1-R against Malignancies in Patient-Derived Orthotopic Xenograft (PDOX) Murine Models. Cells. 2019 06 16; 8(6). Murakami T, Hiroshima Y, Miyake K, Kiyuna T, Endo I, Zhao M, Hoffman RM. PMID: 31208120; PMCID: PMC6628209.
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    274. The combination of gemcitabine and docetaxel arrests a doxorubicin-resistant dedifferentiated liposarcoma in a patient-derived orthotopic xenograft model. Biomed Pharmacother. 2019 Sep; 117:109093. Miyake K, Higuchi T, Oshiro H, Zhang Z, Sugisawa N, Park JH, Razmjooei S, Katsuya Y, Barangi M, Li Y, Nelson SD, Murakami T, Homma Y, Hiroshima Y, Matsuyama R, Bouvet M, Chawla SP, Singh SR, Endo I, Hoffman RM. PMID: 31200257.
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    275. Knockdown of Histone Methyltransferase WHSC1 Induces Apoptosis and Inhibits Cell Proliferation and Tumorigenesis in Salivary Adenoid Cystic Carcinoma. Anticancer Res. 2019 Jun; 39(6):2729-2737. Liu C, Jiang YH, Zhao ZL, Wu HW, Zhang L, Yang Z, Hoffman RM, Zheng JW. PMID: 31177108.
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    276. Traditional Chinese Medicine (TCM) Astragalus Membranaceus and Curcuma Wenyujin Promote Vascular Normalization in Tumor-derived Endothelial Cells of Human Hepatocellular Carcinoma. Anticancer Res. 2019 Jun; 39(6):2739-2747. Zang W, Bian H, Huang X, Yin G, Zhang C, Han LI, Hao P, Ding S, Sun YU, Yang Z, Hoffman RM, Tang D. PMID: 31177109.
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    277. Improved antibody-guided surgery with a near-infrared dye on a pegylated linker for CEA-positive tumors. J Biomed Opt. 2019 06; 24(6):1-9. Yazaki P, Lwin T, Minnix M, Li L, Sherman A, Molnar J, Miller A, Frankel P, Chea J, Poku E, Bowles N, Hoffman R, Shively J, Bouvet M. PMID: 31254333; PMCID: PMC6978469.
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    278. Cyt-Geist: Current and Future Challenges in Cytometry: Reports of the CYTO 2018 Conference Workshops. Cytometry A. 2019 06; 95(6):598-644. Czechowska K, Lannigan J, Wang L, Arcidiacono J, Ashhurst TM, Barnard RM, Bauer S, Bispo C, Bonilla DL, Brinkman RR, Cabanski M, Chang HD, Chakrabarti L, Chojnowski G, Cotleur B, Degheidy H, Dela Cruz GV, Eck S, Elliott J, Errington R, Filby A, Gagnon D, Gardner R, Green C, Gregory M, Groves CJ, Hall C, Hammes F, Hedrick M, Hoffman R, Icha J, Ivaska J, Jenner DC, Jones D, Kerckhof FM, Kukat C, Lanham D, Leavesley S, Lee M, Lin-Gibson S, Litwin V, Liu Y, Molloy J, Moore JS, Müller S, Nedbal J, Niesner R, Nitta N, Ohlsson-Wilhelm B, Paul NE, Perfetto S, Portat Z, Props R, Radtke S, Rayanki R, Rieger A, Rogers S, Rubbens P, Salomon R, Schiemann M, Sharpe J, Sonder SU, Stewart JJ, Sun Y, Ulrich H, Van Isterdael G, Vitaliti A, van Vreden C, Weber M, Zimmermann J, Vacca G, Wallace P, Tárnok A. PMID: 31207046.
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    279. Targeting neddylation inhibits intravascular survival and extravasation of cancer cells to prevent lung-cancer metastasis. Cell Biol Toxicol. 2019 06; 35(3):233-245. Jiang Y, Liang Y, Li L, Zhou L, Cheng W, Yang X, Yang X, Qi H, Yu J, Jeong LS, Hoffman RM, Zheng P, Jia L. PMID: 31140025.
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    280. Anti-Claudin-1 Conjugated to a Near-Infrared Fluorophore Targets Colon Cancer in PDOX Mouse Models. J Surg Res. 2019 10; 242:145-150. Hollandsworth HM, Lwin TM, Amirfakhri S, Filemoni F, Batra SK, Hoffman RM, Dhawan P, Bouvet M. PMID: 31077946; PMCID: PMC7144806.
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    281. Pazopanib regresses a doxorubicin-resistant synovial sarcoma in a patient-derived orthotopic xenograft mouse model. Tissue Cell. 2019 Jun; 58:107-111. Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyake M, Nelson SD, Russell TA, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Higuchi T, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31133237.
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    282. Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review. Cells. 2019 05 02; 8(5). Kawaguchi K, Han Q, Li S, Tan Y, Igarashi K, Murakami T, Unno M, Hoffman RM. PMID: 31052611; PMCID: PMC6562625.
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    283. Tumor-targeting Salmonella typhimurium A1-R overcomes nab-paclitaxel resistance in a cervical cancer PDOX mouse model. Arch Gynecol Obstet. 2019 06; 299(6):1683-1690. Miyake K, Murata T, Murakami T, Zhao M, Kiyuna T, Kawaguchi K, Igarashi K, Miyake M, Lwin TM, Hozumi C, Komatsu S, Kikuchi T, Bouvet M, Shimoya K, Singh SR, Endo I, Hoffman RM. PMID: 30953192; PMCID: PMC11066583.
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    284. Trabectedin and irinotecan combination regresses a cisplatinum-resistant osteosarcoma in a patient-derived orthotopic xenograft nude-mouse model. Biochem Biophys Res Commun. 2019 May 28; 513(2):326-331. Higuchi T, Miyake K, Oshiro H, Sugisawa N, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Chawla SP, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 30955860.
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    285. Temozolomide targets and arrests a doxorubicin-resistant follicular dendritic-cell sarcoma patient-derived orthotopic xenograft mouse model. Tissue Cell. 2019 Jun; 58:17-23. Oshiro H, Tome Y, Kiyuna T, Miyake K, Kawaguchi K, Higuchi T, Miyake M, Zang Z, Razmjooei S, Barangi M, Wangsiricharoen S, Nelson SD, Li Y, Bouvet M, Singh SR, Kanaya F, Hoffman RM. PMID: 31133242.
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    286. Chemo-resistant Gastric Cancer Associated Gene Expression Signature: Bioinformatics Analysis Based on Gene Expression Omnibus. Anticancer Res. 2019 Apr; 39(4):1689-1698. Liu JB, Jian T, Yue C, Chen D, Chen W, Bao TT, Liu HX, Cao Y, Li WB, Yang Z, Hoffman RM, Yu C. PMID: 30952707.
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    287. P-Glycoprotein Overexpression Is Associated With Cisplatin Resistance in Human Osteosarcoma. Anticancer Res. 2019 Apr; 39(4):1711-1718. He C, Sun Z, Hoffman RM, Yang Z, Jiang Y, Wang L, Hao Y. PMID: 30952710.
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    288. Surgical and histological boundary of the hepatic hilar plate system: basic study relevant to surgery for hilar cholangiocarcinoma regarding the "true" proximal ductal margin. J Hepatobiliary Pancreat Sci. 2019 May; 26(5):159-168. Kikuchi Y, Matuyama R, Hiroshima Y, Murakami T, Bouvet M, Morioka D, Hoffman RM, Endo I. PMID: 30825363.
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    289. The combination of olaratumab with gemcitabine and docetaxel arrests a chemotherapy-resistant undifferentiated soft-tissue sarcoma in a patient-derived orthotopic xenograft mouse model. Cancer Chemother Pharmacol. 2019 06; 83(6):1075-1082. Higuchi T, Miyake K, Sugisawa N, Oshiro H, Zhang Z, Razmjooei S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 30929053.
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    290. Olaratumab combined with doxorubicin and ifosfamide overcomes individual doxorubicin and olaratumab resistance of an undifferentiated soft-tissue sarcoma in a PDOX mouse model. Cancer Lett. 2019 06 01; 451:122-127. Higuchi T, Miyake K, Sugisawa N, Oshiro H, Zhang Z, Razmjooei S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 30867142.
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    291. β-Catenin Expression Correlates With Prognosis in Hepatocellular Carcinoma Patients Treated With Transcatheter Arterial Chemoembolization. Anticancer Res. 2019 Mar; 39(3):1129-1134. Xu X, Gao D, Yuan X, Liu LI, Zhang X, Liang X, Chen S, Ai M, Chen BO, Shi D, Yang Z, Hoffman RM, Xu J. PMID: 30842141.
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    292. A patient-derived orthotopic xenograft (PDOX) nude-mouse model precisely identifies effective and ineffective therapies for recurrent leiomyosarcoma. Pharmacol Res. 2019 04; 142:169-175. Zhang Z, Hu K, Kiyuna T, Miyake K, Kawaguchi K, Igarashi K, Nelson SD, Li Y, Singh SR, Hoffman RM. PMID: 30807865.
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    293. Osimertinib Regresses an EGFR-Mutant Cisplatinum- Resistant Lung Adenocarcinoma Growing in the Brain in Nude Mice. Transl Oncol. 2019 Apr; 12(4):640-645. Higuchi T, Oshiro H, Zhang Z, Miyake K, Sugisawa N, Katsuya Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Zhao M, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 30807997; PMCID: PMC6393699.
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    294. Regorafenib regressed a doxorubicin-resistant Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude mouse model. Cancer Chemother Pharmacol. 2019 05; 83(5):809-815. Miyake K, Kiyuna T, Kawaguchi K, Higuchi T, Oshiro H, Zhang Z, Wangsiricharoen S, Razmjooei S, Li Y, Nelson SD, Murakami T, Hiroshima Y, Matsuyama R, Bouvet M, Chawla SP, Singh SR, Endo I, Hoffman RM. PMID: 30758647.
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    295. Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Encapsulated on Polyvinylidene Fluoride Membranes (PFM) Promote Functional Recovery from Spinal Cord Injury. Stem Cell Rev Rep. 2019 02; 15(1):59-66. Obara K, Tohgi N, Shirai K, Mii S, Hamada Y, Arakawa N, Aki R, Singh SR, Hoffman RM, Amoh Y. PMID: 30341634.
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    296. Combining Tumor-Selective Bacterial Therapy with Salmonella typhimurium A1-R and Cancer Metabolism Targeting with Oral Recombinant Methioninase Regressed an Ewing's Sarcoma in a Patient-Derived Orthotopic Xenograft Model. Chemotherapy. 2018; 63(5):278-283. Miyake K, Kiyuna T, Li S, Han Q, Tan Y, Zhao M, Oshiro H, Kawaguchi K, Higuchi T, Zhang Z, Razmjooei S, Barangi M, Wangsiricharoen S, Murakami T, Singh AS, Li Y, Nelson SD, Eilber FC, Bouvet M, Hiroshima Y, Chishima T, Matsuyama R, Singh SR, Endo I, Hoffman RM. PMID: 30673664.
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    297. Gemcitabine combined with docetaxel precisely regressed a recurrent leiomyosarcoma peritoneal metastasis in a patient-derived orthotopic xenograft (PDOX) model. Biochem Biophys Res Commun. 2019 02 19; 509(4):1041-1046. Miyake K, Kiyuna T, Miyake M, Kawaguchi K, Zhang Z, Wangsiricharoen S, Razmjooei S, Oshiro H, Higuchi T, Li Y, Nelson SD, Murakami T, Hiroshima Y, Kumamoto T, Matsuyama R, Bouvet M, Singh SR, Chawla SP, Endo I, Hoffman RM. PMID: 30660363.
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    298. The combination of gemcitabine and nab-paclitaxel as a novel effective treatment strategy for undifferentiated soft-tissue sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model. Biomed Pharmacother. 2019 Mar; 111:835-840. Higuchi T, Kawaguchi K, Miyake K, Oshiro H, Zhang Z, Razmjooei S, Wangsiricharoen S, Igarashi K, Yamamoto N, Hayashi K, Kimura H, Miwa S, Nelson SD, Dry SM, Li Y, Chawla SP, Eilber FC, Singh SR, Tsuchiya H, Hoffman RM. PMID: 30616082.
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    299. Role of the tumor microenvironment in pancreatic cancer. Ann Gastroenterol Surg. 2019 Mar; 3(2):130-137. Murakami T, Hiroshima Y, Matsuyama R, Homma Y, Hoffman RM, Endo I. PMID: 30923782; PMCID: PMC6422798.
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    300. Pilot Phase I Clinical Trial of Methioninase on High-Stage Cancer Patients: Rapid Depletion of Circulating Methionine. Methods Mol Biol. 2019; 1866:231-242. Hoffman RM, Tan Y, Li S, Han Q, Zavala J, Zavala J. PMID: 30725419.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCellsCTClinical Trials
    301. Development of Recombinant Methioninase for Cancer Treatment. Methods Mol Biol. 2019; 1866:107-131. Hoffman RM, Tan Y, Li S, Han Q, Yagi S, Takakura T, Takimoto A, Inagaki K, Kudou D. PMID: 30725412.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    302. Methioninase Cell-Cycle Trap Cancer Chemotherapy. Methods Mol Biol. 2019; 1866:133-148. Hoffman RM, Yano S, Igarashi K. PMID: 30725413.
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    303. High Efficacy of Recombinant Methioninase on Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Cancer. Methods Mol Biol. 2019; 1866:149-161. Hoffman RM, Murakami T, Kawaguchi K, Igarashi K, Tan Y, Li S, Han Q. PMID: 30725414.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    304. Total Methionine Restriction Treatment of Cancer. Methods Mol Biol. 2019; 1866:163-171. Hoffman RM, Kokkinakis DM, Frenkel EP. PMID: 30725415.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    305. Methioninase Gene Therapy. Methods Mol Biol. 2019; 1866:173-197. Hoffman RM, Miki K, Al-Refaie W, Xu M, Tan Y. PMID: 30725416.
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    306. Safety and Toxicity of Recombinant Methioninase and Polyethylene Glycol (PEG) Recombinant Methioninase in Primates. Methods Mol Biol. 2019; 1866:211-229. Hoffman RM, Yang Z, Tan Y, Han Q, Li S, Yagi S. PMID: 30725418.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    307. Methionine Restriction and Life-Span Extension. Methods Mol Biol. 2019; 1866:263-266. Hoffman RM. PMID: 30725421.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    308. L-[Methyl-11C] Methionine-Positron-Emission Tomography (MET-PET). Methods Mol Biol. 2019; 1866:267-271. Hoffman RM. PMID: 30725422.
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    309. Is the Hoffman Effect for Methionine Overuse Analogous to the Warburg Effect for Glucose Overuse in Cancer? Methods Mol Biol. 2019; 1866:273-278. Hoffman RM. PMID: 30725423.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    310. Recombinant Methioninase as a DNA Demethylation Agent. Methods Mol Biol. 2019; 1866:279-284. Hoffman RM, Machover D. PMID: 30725424.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    311. Tumor-Specific S/G2-Phase Cell Cycle Arrest of Cancer Cells by Methionine Restriction. Methods Mol Biol. 2019; 1866:49-60. Hoffman RM, Yano S. PMID: 30725407.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    312. Efficacy of Methionine-Restricted Diets on Cancers In Vivo. Methods Mol Biol. 2019; 1866:75-81. Hoffman RM, Hoshiya Y, Guo W. PMID: 30725409.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    313. Afterword: Oral Methioninase-Answer to Cancer and Fountain of Youth? Methods Mol Biol. 2019; 1866:311-322. Hoffman RM, Han Q, Kawaguchi K, Li S, Tan Y. PMID: 30725426.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    314. Clinical Studies of Methionine-Restricted Diets for Cancer Patients. Methods Mol Biol. 2019; 1866:95-105. Hoffman RM. PMID: 30725411.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    315. Dietary Methionine Restriction-Based Cancer Chemotherapy in Rodents. Methods Mol Biol. 2019; 1866:83-94. Hoffman RM, Stern PH. PMID: 30725410.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    316. Altered Methionine Metabolism in Cancer Cells. Methods Mol Biol. 2019; 1866:13-26. Hoffman RM, Stern PH, Coalson DW, Douglas Wallace C, Erbe RW. PMID: 30725404.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    317. Linkage of Methionine Dependence and Other Features of Malignancy. Methods Mol Biol. 2019; 1866:27-36. Hoffman RM, Erbe RW. PMID: 30725405.
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    318. Detection of Metastasis in a Patient-derived Orthotopic Xenograft (PDOX) Model of Undifferentiated Pleomorphic Sarcoma with Red Fluorescent Protein. Anticancer Res. 2019 Jan; 39(1):81-85. Oshiro H, Kiyuna T, Tome Y, Miyake K, Kawaguchi K, Higuchi T, Miyake M, Zhang Z, Razmjooei S, Barangi M, Wangsiricharoen S, Nelson SD, Li Y, Bouvet M, Singh SR, Kanaya F, Hoffman RM. PMID: 30591443.
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    319. Human Hair Follicle Associated-Pluripotent (hHAP) Stem Cells Differentiate to Cardiac Muscle Cells. Methods Mol Biol. 2019; 1879:385-392. Hoffman RM. PMID: 29992514.
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    320. Fluorescent humanized anti-CEA antibody specifically labels metastatic pancreatic cancer in a patient-derived orthotopic xenograft (PDOX) mouse model. Oncotarget. 2018 Dec 18; 9(99):37333-37342. Lwin TM, Miyake K, Murakami T, DeLong JC, Amirfakhri S, Filemoni F, Yoon SN, Yazaki PJ, Shivley JE, Datnow B, Clary BM, Hoffman RM, Bouvet M. PMID: 30647873; PMCID: PMC6324662.
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    321. Fluorescent Proteins as Sensors for Cellular Behavior in Mice. Prog Mol Biol Transl Sci. 2018; 160:29-45. Hoffman RM. PMID: 30470291.
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    322. Metabolic targeting with recombinant methioninase combined with palbociclib regresses a doxorubicin-resistant dedifferentiated liposarcoma. Biochem Biophys Res Commun. 2018 12 02; 506(4):912-917. Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyaki M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Higuchi T, Singh AS, Chmielowski B, Nelson SD, Russell TA, Eckardt MA, Dry SM, Li Y, Singh SR, Chawla SP, Eilber FC, Tsuchiya H, Hoffman RM. PMID: 30392912.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    323. Hair Follicle-Associated Pluripotent(HAP) Stem Cells. Prog Mol Biol Transl Sci. 2018; 160:23-28. Hoffman RM, Amoh Y. PMID: 30470290.
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    324. Real-Time Determination of the Cell-Cycle Position of Individual Cells within Live Tumors Using FUCCI Cell-Cycle Imaging. Cells. 2018 Oct 14; 7(10). Yano S, Hoffman RM. PMID: 30322204; PMCID: PMC6210921.
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    325. A combination of irinotecan/cisplatinum and irinotecan/temozolomide or tumor-targeting Salmonella typhimurium A1-R arrest doxorubicin- and temozolomide-resistant myxofibrosarcoma in a PDOX mouse model. Biochem Biophys Res Commun. 2018 11 02; 505(3):733-739. Kiyuna T, Tome Y, Murakami T, Miyake K, Igarashi K, Kawaguchi K, Oshiro H, Higuchi T, Miyake M, Sugisawa N, Zhang Z, Razmjooei S, Wangsiricharoen S, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Eckardt MA, Singh AS, Chawla S, Kanaya F, Eilber FC, Singh SR, Zhao M, Hoffman RM. PMID: 30292411.
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    326. Color-coded Imaging of the Circulating Tumor Cell Microenvironment. Anticancer Res. 2018 Oct; 38(10):5635-5638. Satake T, Suetsugu A, Nakamura M, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. PMID: 30275181.
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    327. Oral Recombinant Methioninase Combined with Caffeine and Doxorubicin Induced Regression of a Doxorubicin-resistant Synovial Sarcoma in a PDOX Mouse Model. Anticancer Res. 2018 Oct; 38(10):5639-5644. Higuchi T, Kawaguchi K, Miyake K, Han Q, Tan Y, Oshiro H, Sugisawa N, Zhang Z, Razmjooei S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Chawla SP, Singh AS, Eilber FC, Singh SR, Tsuchiya H, Hoffman RM. PMID: 30275182.
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    328. Tumor targeting Salmonella typhimurium A1-R in combination with gemcitabine (GEM) regresses partially GEM-resistant pancreatic cancer patient-derived orthotopic xenograft (PDOX) nude mouse models. Cell Cycle. 2018; 17(16):2019-2026. Kawaguchi K, Miyake K, Zhao M, Kiyuna T, Igarashi K, Miyake M, Higuchi T, Oshiro H, Bouvet M, Unno M, Hoffman RM. PMID: 29963961; PMCID: PMC6224272.
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    329. Tumor-targeting Salmonella typhimurium A1-R overcomes partial carboplatinum-resistance of a cancer of unknown primary (CUP). Tissue Cell. 2018 Oct; 54:144-149. Miyake K, Kiyuna T, Miyake M, Zhao M, Wangsiricharoen S, Kawaguchi K, Zhang Z, Higuchi T, Razmjooei S, Li Y, Nelson SD, Russell T, Singh A, Murakami T, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Singh SR, Chawla SP, Eilber FC, Endo I, Hoffman RM. PMID: 30309504.
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    330. Ultrasound Microbubble Delivery Targeting Intraplaque Neovascularization Inhibits Atherosclerotic Plaque in an APOE-deficient Mouse Model. In Vivo. 2018 Sep-Oct; 32(5):1025-1032. Yuan H, Hu H, Sun J, Shi M, Yu H, Li C, Sun YU, Yang Z, Hoffman RM. PMID: 30150423; PMCID: PMC6199608.
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    331. Combination therapy of tumor-targeting Salmonella typhimurium A1-R and oral recombinant methioninase regresses a BRAF-V600E-negative melanoma. Biochem Biophys Res Commun. 2018 09 18; 503(4):3086-3092. Kawaguchi K, Higuchi T, Li S, Han Q, Tan Y, Igarashi K, Zhao M, Miyake K, Kiyuna T, Miyake M, Ohshiro H, Sugisawa N, Zhang Z, Razmjooei S, Wangsiricharoen S, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Eckardt MA, Singh AS, Singh SR, Eilber FC, Unno M, Hoffman RM. PMID: 30166061.
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    332. Imaging the interaction of αv integrin-GFP in osteosarcoma cells with RFP-expressing host stromal cells and tumor-scaffold collagen in the primary and metastatic tumor microenvironment. J Cell Biochem. 2019 01; 120(1):283-289. Tome Y, Kiyuna T, Uehara F, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM. PMID: 30145815.
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    333. Patterns of sensitivity to a panel of drugs are highly individualised for undifferentiated/unclassified soft tissue sarcoma (USTS) in patient-derived orthotopic xenograft (PDOX) nude-mouse models. J Drug Target. 2019 02; 27(2):211-216. Kawaguchi K, Igarashi K, Miyake K, Kiyuna T, Miyake M, Singh AS, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Unno M, Singh SR, Eilber FC, Hoffman RM. PMID: 30024282.
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    334. Trabectedin arrests a doxorubicin-resistant PDGFRA-activated liposarcoma patient-derived orthotopic xenograft (PDOX) nude mouse model. BMC Cancer. 2018 Aug 20; 18(1):840. Kiyuna T, Tome Y, Murakami T, Kawaguchi K, Igarashi K, Miyake K, Miyake M, Li Y, Nelson SD, Dry SM, Singh AS, Russell TA, Elliott I, Singh SR, Kanaya F, Eilber FC, Hoffman RM. PMID: 30126369; PMCID: PMC6102848.
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    335. Advantages of patient-derived orthotopic mouse models and genetic reporters for developing fluorescence-guided surgery. J Surg Oncol. 2018 Aug; 118(2):253-264. Lwin TM, Hoffman RM, Bouvet M. PMID: 30080930; PMCID: PMC6146062.
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    336. White paper on microbial anti-cancer therapy and prevention. J Immunother Cancer. 2018 08 06; 6(1):78. Forbes NS, Coffin RS, Deng L, Evgin L, Fiering S, Giacalone M, Gravekamp C, Gulley JL, Gunn H, Hoffman RM, Kaur B, Liu K, Lyerly HK, Marciscano AE, Moradian E, Ruppel S, Saltzman DA, Tattersall PJ, Thorne S, Vile RG, Zhang HH, Zhou S, McFadden G. PMID: 30081947; PMCID: PMC6091193.
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    337. Intravital microscopy of osteolytic progression and therapy response of cancer lesions in the bone. Sci Transl Med. 2018 08 01; 10(452). Dondossola E, Alexander S, Holzapfel BM, Filippini S, Starbuck MW, Hoffman RM, Navone N, De-Juan-Pardo EM, Logothetis CJ, Hutmacher DW, Friedl P. PMID: 30068572; PMCID: PMC6326183.
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    338. Color-coded Imaging Distinguishes Cancer Cells, Stromal Cells, and Recombinant Cancer-stromal Cells in the Tumor Microenvironment During Metastasis. Anticancer Res. 2018 Aug; 38(8):4417-4423. Nakamura M, Suetsugu A, Hasegawa K, Satake T, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. PMID: 30061205.
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    339. Analysis of Anticancer Activity and Chemical Sensitization Effects of Dendropanax morbifera and Commersonia bartramia Extracts. Anticancer Res. 2018 Jul; 38(7):3853-3861. Kim S, Park SG, Song YJ, Park JK, Choi CH, Lee S, Hoffman RM. PMID: 29970505.
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    340. Tumor-targeting Salmonella typhimurium A1-R arrests a doxorubicin-resistant PDGFRA-amplified patient-derived orthotopic xenograft mouse model of pleomorphic liposarcoma. J Cell Biochem. 2018 09; 119(9):7827-7833. Kiyuna T, Tome Y, Murakami T, Zhao M, Miyake K, Igarashi K, Kawaguchi K, Miyake M, Oshiro H, Higuchi T, Li Y, Dry SM, Nelson SD, Russell TA, Eckardt MA, Singh AS, Kanaya F, Eilber FC, Hoffman RM. PMID: 29932244; PMCID: PMC6150816.
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    341. Oral recombinant methioninase (o-rMETase) is superior to injectable rMETase and overcomes acquired gemcitabine resistance in pancreatic cancer. Cancer Lett. 2018 09 28; 432:251-259. Kawaguchi K, Miyake K, Han Q, Li S, Tan Y, Igarashi K, Kiyuna T, Miyake M, Higuchi T, Oshiro H, Zhang Z, Razmjooei S, Wangsiricharoen S, Bouvet M, Singh SR, Unno M, Hoffman RM. PMID: 29928962.
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    342. In silico-designed mutations increase variable new-antigen receptor single-domain antibodies for VEGF165 neutralization. Oncotarget. 2018 Jun 15; 9(46):28016-28029. Millán-Gómez D, Dueñas S, Muñoz PLA, Camacho-Villegas T, Elosua C, Cabanillas-Bernal O, Escalante T, Perona A, Abia D, Drescher F, Fournier PGJ, Ramos MA, Mares RE, Paniagua-Solis J, Mata-Gonzalez T, Gonzalez-Canudas J, Hoffman RM, Licea-Navarro A, Sánchez-Campos N. PMID: 29963259; PMCID: PMC6021326.
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    343. Erratum: Publisher Correction: Is DNA methylation the new guardian of the genome? Mol Cytogenet. 2018; 11:38. Hoffman RM. PMID: 29946362; PMCID: PMC6001167.
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    344. Tumor-targeting Salmonella typhimurium A1-R suppressed an imatinib-resistant gastrointestinal stromal tumor with c-kit exon 11 and 17 mutations. Heliyon. 2018 Jun; 4(6):e00643. Miyake K, Kawaguchi K, Miyake M, Zhao M, Kiyuna T, Igarashi K, Zhang Z, Murakami T, Li Y, Nelson SD, Bouvet M, Elliott I, Russell TA, Singh AS, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Singh SR, Endo I, Eilber FC, Hoffman RM. PMID: 30003151; PMCID: PMC6040627.
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    345. Moesin Up-regulation Is Associated with Enhanced Tumor Progression Imaged Non-invasively in an Orthotopic Mouse Model of Human Glioblastoma. Anticancer Res. 2018 Jun; 38(6):3267-3272. Wang Q, Lu X, Wang J, Yang Z, Hoffman RM, Wu X. PMID: 29848673.
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    346. The development of fluorescence guided surgery for pancreatic cancer: from bench to clinic. Expert Rev Anticancer Ther. 2018 07; 18(7):651-662. Lwin TM, Hoffman RM, Bouvet M. PMID: 29768067; PMCID: PMC6298876.
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    347. Doxorubicin-resistant pleomorphic liposarcoma with PDGFRA gene amplification is targeted and regressed by pazopanib in a patient-derived orthotopic xenograft mouse model. Tissue Cell. 2018 Aug; 53:30-36. Kiyuna T, Murakami T, Tome Y, Igarashi K, Kawaguchi K, Miyake K, Miyake M, Li Y, Nelson SD, Dry SM, Singh AS, Russell TA, Singh SR, Kanaya F, Eilber FC, Hoffman RM. PMID: 30060824.
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    348. Targeting altered cancer methionine metabolism with recombinant methioninase (rMETase) overcomes partial gemcitabine-resistance and regresses a patient-derived orthotopic xenograft (PDOX) nude mouse model of pancreatic cancer. Cell Cycle. 2018; 17(7):868-873. Kawaguchi K, Miyake K, Han Q, Li S, Tan Y, Igarashi K, Lwin TM, Higuchi T, Kiyuna T, Miyake M, Oshiro H, Bouvet M, Unno M, Hoffman RM. PMID: 29623758; PMCID: PMC6056209.
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    349. Temozolomide regresses a doxorubicin-resistant undifferentiated spindle-cell sarcoma patient-derived orthotopic xenograft (PDOX): precision-oncology nude-mouse model matching the patient with effective therapy. J Cell Biochem. 2018 08; 119(8):6598-6603. Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyake M, Li Y, Nelson SD, Dry SM, Singh AS, Elliott IA, Russell TA, Eckardt MA, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 29737543.
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    350. MEK inhibitor trametinib in combination with gemcitabine regresses a patient-derived orthotopic xenograft (PDOX) pancreatic cancer nude mouse model. Tissue Cell. 2018 Jun; 52:124-128. Kawaguchi K, Igarashi K, Miyake K, Lwin TM, Miyake M, Kiyuna T, Hwang HK, Murakami T, Delong JC, Singh SR, Clary B, Bouvet M, Unno M, Hoffman RM. PMID: 29857821.
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    351. Exploiting methionine restriction for cancer treatment. Biochem Pharmacol. 2018 08; 154:170-173. Chaturvedi S, Hoffman RM, Bertino JR. PMID: 29733806.
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    352. Patient-derived orthotopic xenograft models for cancer of unknown primary precisely distinguish chemotherapy, and tumor-targeting S. typhimurium A1-R is superior to first-line chemotherapy. Signal Transduct Target Ther. 2018; 3:12. Miyake K, Kiyuna T, Miyake M, Kawaguchi K, Yoon SN, Zhang Z, Igarashi K, Razmjooei S, Wangsiricharoen S, Murakami T, Li Y, Nelson SD, Russell TA, Singh AS, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Singh SR, Endo I, Eilber FC, Hoffman RM. PMID: 29713497; PMCID: PMC5923205.
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    353. Tumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: decoy, trap and kill chemotherapy moves toward the clinic. Cell Cycle. 2018; 17(6):801-809. Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyake M, Li S, Han Q, Tan Y, Zhao M, Li Y, Nelson SD, Dry SM, Singh AS, Elliott IA, Russell TA, Eckardt MA, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 29374999; PMCID: PMC5969544.
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    354. Recombinant methioninase combined with doxorubicin (DOX) regresses a DOX-resistant synovial sarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model. Oncotarget. 2018 Apr 10; 9(27):19263-19272. Igarashi K, Kawaguchi K, Li S, Han Q, Tan Y, Gainor E, Kiyuna T, Miyake K, Miyake M, Higuchi T, Oshiro H, Singh AS, Eckardt MA, Nelson SD, Russell TA, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 29721200; PMCID: PMC5922394.
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    355. Visualizing the Tumor Microenvironment by Color-coded Imaging in Orthotopic Mouse Models of Cancer. Anticancer Res. 2018 04; 38(4):1847-1857. Suetsugu A, Shimizu M, Saji S, Moriwaki H, Hoffman RM. PMID: 29599301.
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    356. Ethanolic Extract of Traditional Chinese Medicine (TCM) Gamboge Inhibits Colon Cancer via the Wnt/Beta-Catenin Signaling Pathway in an Orthotopic Mouse Model. Anticancer Res. 2018 04; 38(4):1917-1925. Wang W, Li Y, Chen Y, Chen H, Zhu P, Xu M, Wang H, Wu M, Yang Z, Hoffman RM, Gu Y. PMID: 29599307.
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    357. Differential Organ-targeting and Cellular Characteristics of Metastatic Human Pancreatic Cancer Cell Lines in Mouse Models. Anticancer Res. 2018 04; 38(4):1927-1935. Satake T, Suetsugu A, Nakamura M, Hasegawa K, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. PMID: 29599308.
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    358. Individualized doxorubicin sensitivity testing of undifferentiated soft tissue sarcoma (USTS) in a patient-derived orthotopic xenograft (PDOX) model demonstrates large differences between patients. Cell Cycle. 2018; 17(5):627-633. Kawaguchi K, Igarashi K, Kiyuna T, Miyake K, Miyake M, Murakami T, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Singh AS, Unno M, Eilber FC, Hoffman RM. PMID: 29384032; PMCID: PMC5969558.
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    359. Targeting methionine with oral recombinant methioninase (o-rMETase) arrests a patient-derived orthotopic xenograft (PDOX) model of BRAF-V600E mutant melanoma: implications for chronic clinical cancer therapy and prevention. Cell Cycle. 2018; 17(3):356-361. Kawaguchi K, Han Q, Li S, Tan Y, Igarashi K, Kiyuna T, Miyake K, Miyake M, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Singh AS, Eckardt MA, Unno M, Eilber FC, Hoffman RM. PMID: 29187018; PMCID: PMC5914727.
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    360. Tumor-targeting Salmonella typhimurium A1-R is a highly effective general therapeutic for undifferentiated soft tissue sarcoma patient-derived orthotopic xenograft nude-mouse models. Biochem Biophys Res Commun. 2018 03 18; 497(4):1055-1061. Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyake M, Singh AS, Eckardt MA, Nelson SD, Russell TA, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Singh SR, Eilber FC, Hoffman RM. PMID: 29481803.
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    361. RT-PCR of peritoneal washings predicts peritoneal pancreatic cancer recurrence. J Surg Res. 2018 06; 226:122-130. Sato K, Mori R, Hiroshima Y, Oba MS, Matsuyama R, Bouvet M, Hoffman RM, Endo I. PMID: 29661277.
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    362. Inhibition of growth and metastasis of triple-negative breast cancer targeted by Traditional Chinese Medicine Tubeimu in orthotopic mice models. Chin J Cancer Res. 2018 Feb; 30(1):112-121. Wang J, Yang X, Han H, Wang L, Bao W, Wang S, Hoffman RM, Yang M, Qi H, An C, Hu K. PMID: 29545725; PMCID: PMC5842225.
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    363. Fluorescence-guided Surgery with Splenic Preservation Prevents Tumor Recurrence in an Orthotopic Nude-mouse Model of Human Pancreatic Cancer. Anticancer Res. 2018 02; 38(2):665-670. Hwang HK, Kang CM, Lee SH, Murakami T, Kiyuna T, Kim SH, Hoffman RM, Bouvet M. PMID: 29374688.
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    364. Tumor-Specific Labeling of Pancreatic Cancer Using a Humanized Anti-CEA Antibody Conjugated to a Near-Infrared Fluorophore. Ann Surg Oncol. 2018 Apr; 25(4):1079-1085. Lwin TM, Murakami T, Miyake K, Yazaki PJ, Shivley JE, Hoffman RM, Bouvet M. PMID: 29372363; PMCID: PMC5842124.
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    365. Bacterial Therapy of Cancer: Promises, Limitations, and Insights for Future Directions. Front Microbiol. 2018; 9:16. Kramer MG, Masner M, Ferreira FA, Hoffman RM. PMID: 29472896; PMCID: PMC5810261.
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    366. Intra-tumor L-methionine level highly correlates with tumor size in both pancreatic cancer and melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse models. Oncotarget. 2018 Feb 16; 9(13):11119-11125. Kawaguchi K, Han Q, Li S, Tan Y, Igarashi K, Miyake K, Kiyuna T, Miyake M, Chemielwski B, Nelson SD, Russell TA, Dry SM, Li Y, Singh AS, Eckardt MA, Unno M, Eilber FC, Hoffman RM. PMID: 29541401; PMCID: PMC5834286.
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    367. Engineered mesenchymal stem-cell-sheets patches prevents postoperative pancreatic leakage in a rat model. Sci Rep. 2018 01 10; 8(1):360. Kim SR, Yi HJ, Lee YN, Park JY, Hoffman RM, Okano T, Shim IK, Kim SC. PMID: 29321630; PMCID: PMC5762914.
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    368. Recombinant methioninase in combination with doxorubicin (DOX) overcomes first-line DOX resistance in a patient-derived orthotopic xenograft nude-mouse model of undifferentiated spindle-cell sarcoma. Cancer Lett. 2018 03 28; 417:168-173. Igarashi K, Kawaguchi K, Li S, Han Q, Tan Y, Murakami T, Kiyuna T, Miyake K, Miyake M, Singh AS, Eckardt MA, Nelson SD, Russell TA, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Singh SR, Eilber FC, Hoffman RM. PMID: 29306021.
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    369. Growth of doxorubicin-resistant undifferentiated spindle-cell sarcoma PDOX is arrested by metabolic targeting with recombinant methioninase. J Cell Biochem. 2018 04; 119(4):3537-3544. Igarashi K, Li S, Han Q, Tan Y, Kawaguchi K, Murakami T, Kiyuna T, Miyake K, Li Y, Nelson SD, Dry SM, Singh AS, Elliott IA, Russell TA, Eckardt MA, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 29143983.
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    370. 3D Sponge-Matrix Histoculture: An Overview. Methods Mol Biol. 2018; 1760:11-17. Hoffman RM. PMID: 29572789.
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    371. In Vivo-Like Growth Patterns of Multiple Types of Tumors in Gelfoam® Histoculture. Methods Mol Biol. 2018; 1760:19-28. Hoffman RM, Freeman AE. PMID: 29572790.
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    372. Expression and Targeting of Tumor Markers in Gelfoam® Histoculture: Potential Individualized Assays for Immuno-Oncology. Methods Mol Biol. 2018; 1760:29-37. Hoffman RM, Guadagni F. PMID: 29572791.
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    373. Development of the Histoculture Drug Response Assay (HDRA). Methods Mol Biol. 2018; 1760:39-48. Hoffman RM, Vescio RA. PMID: 29572792.
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    374. Diagnosis and Pathological Analysis of Patient Cancers by Detection of Proliferating Cells in Gelfoam® Histoculture. Methods Mol Biol. 2018; 1760:49-60. Hoffman RM. PMID: 29572793.
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    375. Clinical Correlation of the Histoculture Drug Response Assay in Gastrointestinal Cancer. Methods Mol Biol. 2018; 1760:61-72. Hoffman RM. PMID: 29572794.
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    376. Prospective Clinical Correlation of the Histoculture Drug Response Assay for Ovarian Cancer. Methods Mol Biol. 2018; 1760:73-81. Hoffman RM, Jung PS, Kim MB, Nam JH. PMID: 29572795.
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    377. Clinical Correlation of the Histoculture Drug Response Assay for Head and Neck Cancer. Methods Mol Biol. 2018; 1760:83-92. Hoffman RM. PMID: 29572796.
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    378. Clinical Usefulness of the Histoculture Drug Response Assay for Breast Cancer. Methods Mol Biol. 2018; 1760:93-100. Hoffman RM, Tanino H. PMID: 29572797.
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    379. Clinical Usefulness of the Histoculture Drug Response Assay for Prostate Cancer and Benign Prostate Hypertrophy (BPH). Methods Mol Biol. 2018; 1760:101-107. Hoffman RM. PMID: 29572798.
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    380. In Vivo-Like Cell-Cycle Phase Distribution of Cancer Cells in Gelfoam® Histoculture Observed in Real Time by FUCCI Imaging. Methods Mol Biol. 2018; 1760:109-123. Hoffman RM, Yano S. PMID: 29572799.
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    381. Methionine Dependency Determination of Human Patient Tumors in Gelfoam® Histoculture. Methods Mol Biol. 2018; 1760:125-131. Hoffman RM. PMID: 29572800.
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    382. Hair-Shaft Growth in Gelfoam® Histoculture of Skin and Isolated Hair Follicles. Methods Mol Biol. 2018; 1760:133-144. Hoffman RM, Li L, Cao W. PMID: 29572801.
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    383. Hair Follicle-Associated Pluripotent (HAP) Stem Cells in Gelfoam® Histoculture for Use in Spinal Cord Repair. Methods Mol Biol. 2018; 1760:145-162. Liu F, Hoffman RM. PMID: 29572802.
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    384. Nerve Growth and Interaction in Gelfoam® Histoculture: A Nervous System Organoid. Methods Mol Biol. 2018; 1760:163-186. Hoffman RM, Mii S, Duong J, Amoh Y. PMID: 29572803.
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    385. Imaging DNA Repair After UV Irradiation Damage of Cancer Cells in Gelfoam® Histoculture. Methods Mol Biol. 2018; 1760:199-203. Miwa S, Hoffman RM. PMID: 29572805.
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    386. Comparison of "Dimensionality" of Cancer Cell Culture in Gelfoam® Histoculture and Matrigel. Methods Mol Biol. 2018; 1760:205-214. Tome Y, Uehara F, Kanaya F, Hoffman RM. PMID: 29572806.
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    387. Imaging the Governing Step of Metastasis in Gelfoam® Histoculture. Methods Mol Biol. 2018; 1760:215-220. Hoffman RM, Chishima T. PMID: 29572807.
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    388. Regorafenib regresses an imatinib-resistant recurrent gastrointestinal stromal tumor (GIST) with a mutation in exons 11 and 17 of c-kit in a patient-derived orthotopic xenograft (PDOX) nude mouse model. Cell Cycle. 2018; 17(6):722-727. Miyake K, Kawaguchi K, Kiyuna T, Miyake M, Igarashi K, Zhang Z, Murakami T, Li Y, Nelson SD, Elliott I, Russell T, Singh A, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Endo I, Eilber FC, Hoffman RM. PMID: 29334307; PMCID: PMC5969563.
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    389. Traditional Chinese Medicine Curcumin Sensitizes Human Colon Cancer to Radiation by Altering the Expression of DNA Repair-related Genes. Anticancer Res. 2018 01; 38(1):131-136. Yang G, Qiu J, Wang D, Tao Y, Song Y, Wang H, Tang J, Wang X, Sun YU, Yang Z, Hoffman RM. PMID: 29277765.
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    390. Tumor-targeting Salmonella typhimurium A1-R Inhibits Osteosarcoma Angiogenesis in the In Vivo Gelfoam® Assay Visualized by Color-coded Imaging. Anticancer Res. 2018 01; 38(1):159-164. Kiyuna T, Tome Y, Uehara F, Murakami T, Zhang Y, Zhao M, Kanaya F, Hoffman RM. PMID: 29277768.
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    391. Effects of siRNA Silencing of TUG1 and LCAL6 Long Non-coding RNAs on Patient-derived Xenograft of Non-small Cell Lung Cancer. Anticancer Res. 2018 01; 38(1):179-186. Fang T, Huang H, Li X, Liao J, Yang Z, Hoffman RM, Cheng XI, Liang L, Hu W, Yun S. PMID: 29277771.
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    392. Beating Heart Cells from Hair-Follicle-Associated Pluripotent (HAP) Stem Cells. Methods Mol Biol. 2018; 1842:241-254. Hoffman RM, Amoh Y. PMID: 30196415.
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    393. Genetic and metabolic comparison of orthotopic and heterotopic patient-derived pancreatic-cancer xenografts to the original patient tumors. Oncotarget. 2018 Jan 30; 9(8):7867-7881. Jun E, Hong SM, Yoo HJ, Kim MB, Won JS, An S, Shim IK, Chang S, Hoffman RM, Kim SC. PMID: 29487698; PMCID: PMC5814265.
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    394. Recombinant methioninase (rMETase) is an effective therapeutic for BRAF-V600E-negative as well as -positive melanoma in patient-derived orthotopic xenograft (PDOX) mouse models. Oncotarget. 2018 Jan 02; 9(1):915-923. Kawaguchi K, Igarashi K, Li S, Han Q, Tan Y, Miyake K, Kiyuna T, Miyake M, Murakami T, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Unno M, Eilber FC, Hoffman RM. PMID: 29416666; PMCID: PMC5787523.
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    395. Temozolomide combined with irinotecan regresses a cisplatinum-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) precision-oncology mouse model. Oncotarget. 2018 Jan 30; 9(8):7774-7781. Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyake M, Li Y, Nelson SD, Dry SM, Singh AS, Elliott IA, Russell TA, Eckardt MA, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 29487690; PMCID: PMC5814257.
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    396. Near-infrared-conjugated humanized anti-carcinoembryonic antigen antibody targets colon cancer in an orthotopic nude-mouse model. J Surg Res. 2017 10; 218:139-143. DeLong JC, Murakami T, Yazaki PJ, Hoffman RM, Bouvet M. PMID: 28985840; PMCID: PMC5650098.
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    397. Splenectomy is associated with an aggressive tumor growth pattern and altered host immunity in an orthotopic syngeneic murine pancreatic cancer model. Oncotarget. 2017 Oct 24; 8(51):88827-88834. Hwang HK, Murakami T, Kiyuna T, Kim SH, Lee SH, Kang CM, Hoffman RM, Bouvet M. PMID: 29179479; PMCID: PMC5687649.
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    398. Eribulin regresses a doxorubicin-resistant Ewing's sarcoma with a FUS-ERG fusion and CDKN2A-deletion in a patient-derived orthotopic xenograft (PDOX) nude mouse model. J Cell Biochem. 2018 01; 119(1):967-972. Miyake K, Murakami T, Kiyuna T, Igarashi K, Kawaguchi K, Li Y, Singh AS, Dry SM, Eckardt MA, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Endo I, Eilber FC, Hoffman RM. PMID: 28681998.
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    399. Regarding the applications of fusion-fluorescence imaging using indocyanine green in laparoscopic hepatectomy. Transl Gastroenterol Hepatol. 2017; 2:70. Lwin TM, Hoffman RM, Bouvet M. PMID: 29034343; PMCID: PMC5638993.
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    400. The combination of temozolomide-irinotecan regresses a doxorubicin-resistant patient-derived orthotopic xenograft (PDOX) nude-mouse model of recurrent Ewing's sarcoma with a FUS-ERG fusion and CDKN2A deletion: Direction for third-line patient therapy. Oncotarget. 2017 Nov 28; 8(61):103129-103136. Miyake K, Murakami T, Kiyuna T, Igarashi K, Kawaguchi K, Miyake M, Li Y, Nelson SD, Dry SM, Bouvet M, Elliott IA, Russell TA, Singh AS, Eckardt MA, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Endo I, Eilber FC, Hoffman RM. PMID: 29262551; PMCID: PMC5732717.
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    401. Implanted hair-follicle-associated pluripotent (HAP) stem cells encapsulated in polyvinylidene fluoride membrane cylinders promote effective recovery of peripheral nerve injury. Cell Cycle. 2017 Oct 18; 16(20):1927-1932. Yamazaki A, Obara K, Tohgi N, Shirai K, Mii S, Hamada Y, Arakawa N, Aki R, Hoffman RM, Amoh Y. PMID: 28886268; PMCID: PMC5638363.
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    402. Hair follicle-associated-pluripotent (HAP) stem cells. Cell Cycle. 2017; 16(22):2169-2175. Amoh Y, Hoffman RM. PMID: 28749199; PMCID: PMC5736337.
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    403. Effective Metabolic Targeting of Human Osteosarcoma Cells In Vitro and in Orthotopic Nude-mouse Models with Recombinant Methioninase. Anticancer Res. 2017 09; 37(9):4807-4812. Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Murakami T, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Hoffman RM. PMID: 28870899.
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    404. Patient-Derived Orthotopic Xenograft (PDOX) Models of Melanoma. Int J Mol Sci. 2017 Aug 31; 18(9). Hoffman RM. PMID: 28858204; PMCID: PMC5618524.
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    405. Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model. Oncotarget. 2017 Oct 17; 8(49):85516-85525. Kawaguchi K, Igarashi K, Li S, Han Q, Tan Y, Kiyuna T, Miyake K, Murakami T, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Unno M, Eilber FC, Hoffman RM. PMID: 29156737; PMCID: PMC5689627.
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    406. Tumor-Targeting Salmonella typhimurium A1-R Promotes Tumoricidal CD8+ T Cell Tumor Infiltration and Arrests Growth and Metastasis in a Syngeneic Pancreatic-Cancer Orthotopic Mouse Model. J Cell Biochem. 2018 01; 119(1):634-639. Murakami T, Hiroshima Y, Zhang Y, Zhao M, Kiyuna T, Hwang HK, Miyake K, Homma Y, Mori R, Matsuyama R, Chishima T, Ichikawa Y, Tanaka K, Bouvet M, Endo I, Hoffman RM. PMID: 28628234.
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    407. Clinical Factors That Affect the Establishment of Soft Tissue Sarcoma Patient-Derived Orthotopic Xenografts: A University of California, Los Angeles, Sarcoma Program Prospective Clinical Trial. JCO Precis Oncol. 2017; 2017. Russell TA, Eckardt MA, Murakami T, Elliott IA, Kawaguchi K, Kiyuna T, Igarashi K, Li Y, Crompton JG, Graham DS, Dry SM, Bernthal N, Yanagawa J, Kalbasi A, Federman N, Chmielowski B, Singh AS, Hoffman RM, Eilber FC. PMID: 30613825; PMCID: PMC6319895.
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    408. Efficacy In Vitro of Caffeine and Valproic Acid on Patient-Derived Undifferentiated Pleomorphic Sarcoma and Rhabdomyosarcoma Cell Lines. Anticancer Res. 2017 08; 37(8):4081-4084. Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Miwa S, Nelson SD, Dry SM, Li Y, Singh AS, Kimura H, Hayashi K, Yamamoto N, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 28739691.
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    409. Chemoprevention by Quercetin of Oral Squamous Cell Carcinoma by Suppression of the NF-κB Signaling Pathway in DMBA-treated Hamsters. Anticancer Res. 2017 08; 37(8):4041-4049. Zhang W, Yin G, Dai J, Sun YU, Hoffman RM, Yang Z, Fan Y. PMID: 28739686.
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    410. Therapeutic Cell-Cycle-Decoy Efficacy of a Telomerase-Dependent Adenovirus in an Orthotopic Model of Chemotherapy-Resistant Human Stomach Carcinomatosis Peritonitis Visualized With FUCCI Imaging. J Cell Biochem. 2017 11; 118(11):3635-3642. Yano S, Takehara K, Tazawa H, Kishimoto H, Urata Y, Kagawa S, Fujiwara T, Hoffman RM. PMID: 27171483.
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    411. MEK inhibitors cobimetinib and trametinib, regressed a gemcitabine-resistant pancreatic-cancer patient-derived orthotopic xenograft (PDOX). Oncotarget. 2017 Jul 18; 8(29):47490-47496. Kawaguchi K, Igarashi K, Murakami T, Kiyuna T, Lwin TM, Hwang HK, Delong JC, Clary BM, Bouvet M, Unno M, Hoffman RM. PMID: 28537897; PMCID: PMC5564580.
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    412. A patient-derived orthotopic xenograft (PDOX) mouse model of a cisplatinum-resistant osteosarcoma lung metastasis that was sensitive to temozolomide and trabectedin: implications for precision oncology. Oncotarget. 2017 Sep 22; 8(37):62111-62119. Igarashi K, Murakami T, Kawaguchi K, Kiyuna T, Miyake K, Zhang Y, Nelson SD, Dry SM, Li Y, Yanagawa J, Russell TA, Singh AS, Tsuchiya H, Elliott I, Eilber FC, Hoffman RM. PMID: 28977930; PMCID: PMC5617490.
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    413. Enhancement of Wound Healing by the Traditional Chinese Medicine Herbal Mixture Sophora flavescens in a Rat Model of Perianal Ulceration. In Vivo. 2017 Jul-Aug; 31(4):543-549. Xu X, Li X, Zhang L, Liu Z, Pan Y, Chen D, Bin D, Deng Q, Sun YU, Hoffman RM, Yang Z, Yuan H. PMID: 28652418; PMCID: PMC5566901.
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    414. Choline-Deficient-Diet-Induced Fatty Liver Is a Metastasis-Resistant Microenvironment. Anticancer Res. 2017 07; 37(7):3429-3434. Nakamura M, Suetsugu A, Hasegawa K, Matsumoto T, Aoki H, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. PMID: 28668831.
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    415. Imaging the Role of Multinucleate Pancreatic Cancer Cells and Cancer-Associated Fibroblasts in Peritoneal Metastasis in Mouse Models. Anticancer Res. 2017 07; 37(7):3435-3440. Hasegawa K, Suetsugu A, Nakamura M, Matsumoto T, Aoki H, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. PMID: 28668832.
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    416. On the role of classical and novel forms of vitamin D in melanoma progression and management. J Steroid Biochem Mol Biol. 2018 03; 177:159-170. Slominski AT, Brozyna AA, Skobowiat C, Zmijewski MA, Kim TK, Janjetovic Z, Oak AS, Jozwicki W, Jetten AM, Mason RS, Elmets C, Li W, Hoffman RM, Tuckey RC. PMID: 28676457; PMCID: PMC5748362.
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    417. A novel anionic-phosphate-platinum complex effectively targets an undifferentiated pleomorphic sarcoma better than cisplatinum and doxorubicin in a patient-derived orthotopic xenograft (PDOX). Oncotarget. 2017 Sep 08; 8(38):63353-63359. Igarashi K, Kawaguchi K, Murakami T, Kiyuna T, Miyake K, Yamamoto N, Hayashi K, Kimura H, Nelson SD, Dry SM, Li Y, Singh AS, Miwa S, Odani A, Eilber FC, Tsuchiya H, Hoffman RM. PMID: 28968995; PMCID: PMC5609927.
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    418. Pancreatic cancer-derived exosomes promote tumor metastasis and liver pre-metastatic niche formation. Oncotarget. 2017 Sep 08; 8(38):63461-63483. Yu Z, Zhao S, Ren L, Wang L, Chen Z, Hoffman RM, Zhou J. PMID: 28969005; PMCID: PMC5609937.
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    419. Locally-applied 5-fluorouracil-loaded slow-release patch prevents pancreatic cancer growth in an orthotopic mouse model. Oncotarget. 2017 Jun 20; 8(25):40140-40151. Shim IK, Yi HJ, Yi HG, Lee CM, Lee YN, Choi YJ, Jeong SY, Jun E, Hoffman RM, Cho DW, Kim SC. PMID: 28498800; PMCID: PMC5522260.
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    420. Salmonella typhimurium A1-R targeting of a chemotherapy-resistant BRAF-V600E melanoma in a patient-derived orthotopic xenograft (PDOX) model is enhanced in combination with either vemurafenib or temozolomide. Cell Cycle. 2017 Jul 03; 16(13):1288-1294. Kawaguchi K, Igarashi K, Murakami T, Kiyuna T, Zhao M, Zhang Y, Nelson SD, Russell TA, Dry SM, Singh AS, Chmielowski B, Li Y, Unno M, Eilber FC, Hoffman RM. PMID: 28622068; PMCID: PMC5531627.
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    421. Neoadjuvant chemoradiotherapy of pancreatic cancer induces a favorable immunogenic tumor microenvironment associated with increased major histocompatibility complex class I-related chain A/B expression. J Surg Oncol. 2017 Sep; 116(3):416-426. Murakami T, Homma Y, Matsuyama R, Mori R, Miyake K, Tanaka Y, Den K, Nagashima Y, Nakazawa M, Hiroshima Y, Ueda M, Tanaka K, Hoffman RM, Bouvet M, Endo I. PMID: 28608409.
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    422. Genetic Recombination Between Stromal and Cancer Cells Results in Highly Malignant Cells Identified by Color-Coded Imaging in a Mouse Lymphoma Model. J Cell Biochem. 2017 12; 118(12):4216-4221. Nakamura M, Suetsugu A, Hasegawa K, Matsumoto T, Aoki H, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. PMID: 28419513.
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    423. Recombinant methioninase effectively targets a Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model. Oncotarget. 2017 May 30; 8(22):35630-35638. Murakami T, Li S, Han Q, Tan Y, Kiyuna T, Igarashi K, Kawaguchi K, Hwang HK, Miyake K, Singh AS, Nelson SD, Dry SM, Li Y, Hiroshima Y, Lwin TM, DeLong JC, Chishima T, Tanaka K, Bouvet M, Endo I, Eilber FC, Hoffman RM. PMID: 28404944; PMCID: PMC5482604.
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    424. Strategies for In Vivo Imaging Using Fluorescent Proteins. J Cell Biochem. 2017 09; 118(9):2571-2580. Hoffman RM. PMID: 27564860.
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    425. Analysis of Stroma Labeling During Multiple Passage of a Sarcoma Imageable Patient-Derived Orthotopic Xenograft (iPDOX) in Red Fluorescent Protein Transgenic Nude Mice. J Cell Biochem. 2017 10; 118(10):3367-3371. Kiyuna T, Murakami T, Tome Y, Kawaguchi K, Igarashi K, Miyake K, Kanaya F, Singh A, Eilber FC, Hoffman RM. PMID: 28300287; PMCID: PMC5550328.
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    426. Intra-arterial administration of tumor-targeting Salmonella typhimurium A1-R regresses a cisplatin-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model. Cell Cycle. 2017 Jun 18; 16(12):1164-1170. Igarashi K, Kawaguchi K, Murakami T, Kiyuna T, Miyake K, Nelson SD, Dry SM, Li Y, Yanagawa J, Russell TA, Singh AS, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 28494180; PMCID: PMC5499917.
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    427. Toxicology and efficacy of tumor-targeting Salmonella typhimurium A1-R compared to VNP 20009 in a syngeneic mouse tumor model in immunocompetent mice. Oncotarget. 2017 Aug 15; 8(33):54616-54628. Zhang Y, Cao W, Toneri M, Zhang N, Kiyuna T, Murakami T, Nelson SD, Dry SM, Li Y, Li S, Wang X, Ma H, Singh AS, Eilber FC, Hoffman RM, Zhao M. PMID: 28903369; PMCID: PMC5589608.
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    428. Moesin Expression Is Associated with Glioblastoma Cell Proliferation and Invasion. Anticancer Res. 2017 05; 37(5):2211-2218. Wang Q, Lu X, Zhao S, Pang M, Wu X, Wu H, Hoffman RM, Yang Z, Zhang Y. PMID: 28476784.
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    429. Color-coded intravital imaging demonstrates a transforming growth factor-β (TGF-β) antagonist selectively targets stromal cells in a human pancreatic-cancer orthotopic mouse model. Cell Cycle. 2017 May 19; 16(10):1008-1014. Murakami T, Hiroshima Y, Miyake K, Hwang HK, Kiyuna T, DeLong JC, Lwin TM, Matsuyama R, Mori R, Kumamoto T, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM. PMID: 28441080; PMCID: PMC5462077.
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    430. Tumor-Targeting Salmonella typhimurium A1-R Sensitizes Melanoma With a BRAF-V600E Mutation to Vemurafenib in a Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model. J Cell Biochem. 2017 08; 118(8):2314-2319. Kawaguchi K, Igarashi K, Murakami T, Zhao M, Zhang Y, Chmielowski B, Kiyuna T, Nelson SD, Russell TA, Dry SM, Li Y, Unno M, Eilber FC, Hoffman RM. PMID: 28106277.
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    431. High Efficacy of Pazopanib on an Undifferentiated Spindle-Cell Sarcoma Resistant to First-Line Therapy Is Identified With a Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model. J Cell Biochem. 2017 09; 118(9):2739-2743. Igarashi K, Kawaguchi K, Murakami T, Kiyuna T, Miyake K, Singh AS, Nelson SD, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 28176365.
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    432. Combination of gemcitabine and docetaxel regresses both gastric leiomyosarcoma proliferation and invasion in an imageable patient-derived orthotopic xenograft (iPDOX) model. Cell Cycle. 2017 Jun 03; 16(11):1063-1069. Kawaguchi K, Igarashi K, Murakami T, Kiyuna T, Nelson SD, Dry SM, Li Y, Russell TA, Singh AS, Chmielowski B, Unno M, Eilber FC, Hoffman RM. PMID: 28426279; PMCID: PMC5499841.
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    433. Is DNA methylation the new guardian of the genome? Mol Cytogenet. 2017; 10:11. Hoffman RM. PMID: 28396696; PMCID: PMC5381125.
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    434. Temozolomide combined with irinotecan caused regression in an adult pleomorphic rhabdomyosarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model. Oncotarget. 2017 Sep 29; 8(44):75874-75880. Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Miwa S, Nelson SD, Dry SM, Li Y, Singh AS, Kimura H, Hayashi K, Yamamoto N, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 29100276; PMCID: PMC5652670.
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    435. High-efficacy targeting of colon-cancer liver metastasis with Salmonella typhimurium A1-R via intra-portal-vein injection in orthotopic nude-mouse models. Oncotarget. 2017 Mar 21; 8(12):19065-19073. Kawaguchi K, Murakami T, Suetsugu A, Kiyuna T, Igarashi K, Hiroshima Y, Zhao M, Zhang Y, Bouvet M, Clary BM, Unno M, Hoffman RM. PMID: 27683127; PMCID: PMC5386670.
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    436. The wayward methyl group and the cascade to cancer. Cell Cycle. 2017 May 03; 16(9):825-829. Hoffman RM. PMID: 28318368; PMCID: PMC5444351.
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    437. The irony of highly-effective bacterial therapy of a patient-derived orthotopic xenograft (PDOX) model of Ewing's sarcoma, which was blocked by Ewing himself 80 years ago. Cell Cycle. 2017 Jun 03; 16(11):1046-1052. Murakami T, Kiyuna T, Kawaguchi K, Igarashi K, Singh AS, Hiroshima Y, Zhang Y, Zhao M, Miyake K, Nelson SD, Dry SM, Li Y, DeLong JC, Lwin TM, Chishima T, Tanaka K, Bouvet M, Endo I, Eilber FC, Hoffman RM. PMID: 28296559; PMCID: PMC5499836.
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    438. Anti-metastatic Efficacy of Traditional Chinese Medicine (TCM) Ginsenoside Conjugated to a VEFGR-3 Antibody on Human Gastric Cancer in an Orthotopic Mouse Model. Anticancer Res. 2017 03; 37(3):979-986. Dai X, Liu D, Liu M, Zhang X, Wang W, Jin F, Qian Y, Wang X, Zhao J, Wu Y, Xiong F, Chang NA, Sun YU, Yang Z, Hoffman RM, Liu Y. PMID: 28314255.
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    439. Antimetastatic Efficacy of the Combination of Caffeine and Valproic Acid on an Orthotopic Human Osteosarcoma Cell Line Model in Nude Mice. Anticancer Res. 2017 03; 37(3):1005-1011. Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Hoffman RM. PMID: 28314258.
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    440. Potential of immunotherapy for sarcoma. Cancer. 2017 05 01; 123(9):1488-1489. Hoffman RM, Singh AS, Eilber FC. PMID: 28241102.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    441. GFP labeling kinetics of triple-negative human breast cancer by a killer-reporter adenovirus in 3D Gelfoam® histoculture. In Vitro Cell Dev Biol Anim. 2017 Jun; 53(6):479-482. Yano S, Takehara K, Miwa S, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 28233141.
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    442. Synergistic Inhibitory Effect of Traditional Chinese Medicine Astragaloside IV and Curcumin on Tumor Growth and Angiogenesis in an Orthotopic Nude-Mouse Model of Human Hepatocellular Carcinoma. Anticancer Res. 2017 02; 37(2):465-473. Zhang S, Tang D, Zang W, Yin G, Dai J, Sun YU, Yang Z, Hoffman RM, Guo X. PMID: 28179291.
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    443. Tumor-targeting Salmonella typhimurium A1-R regresses an osteosarcoma in a patient-derived xenograft model resistant to a molecular-targeting drug. Oncotarget. 2017 Jan 31; 8(5):8035-8042. Murakami T, Igarashi K, Kawaguchi K, Kiyuna T, Zhang Y, Zhao M, Hiroshima Y, Nelson SD, Dry SM, Li Y, Yanagawa J, Russell T, Federman N, Singh A, Elliott I, Matsuyama R, Chishima T, Tanaka K, Endo I, Eilber FC, Hoffman RM. PMID: 28030831; PMCID: PMC5352380.
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    444. High-metastatic triple-negative breast-cancer variants selected in vivo become chemoresistant in vitro. In Vitro Cell Dev Biol Anim. 2017 Apr; 53(4):285-287. Yano S, Takehara K, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 28127701.
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    445. A novel method for RNA extraction from FFPE samples reveals significant differences in biomarker expression between orthotopic and subcutaneous pancreatic cancer patient-derived xenografts. Oncotarget. 2017 Jan 24; 8(4):5885-5894. Hoover M, Adamian Y, Brown M, Maawy A, Chang A, Lee J, Gharibi A, Katz MH, Fleming J, Hoffman RM, Bouvet M, Doebler R, Kelber JA. PMID: 27602776; PMCID: PMC5351598.
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    446. Reconstitution of a metastatic-resistant tumor microenvironment with cancer-associated fibroblasts enables metastasis. Cell Cycle. 2017 Mar 19; 16(6):533-535. Murata T, Mekada E, Hoffman RM. PMID: 28103135; PMCID: PMC5384587.
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    447. Eradication of melanoma in vitro and in vivo via targeting with a Killer-Red-containing telomerase-dependent adenovirus. Cell Cycle. 2017 Aug 18; 16(16):1502-1508. Takehara K, Yano S, Tazawa H, Kishimoto H, Narii N, Mizuguchi H, Urata Y, Kagawa S, Fujiwara T, Hoffman RM. PMID: 28055296; PMCID: PMC5584861.
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    448. Comparison of Tumor Recurrence After Resection of Highly- and Poorly-Metastatic Triple-negative Breast Cancer in Orthotopic Nude-Mouse Models. Anticancer Res. 2017 01; 37(1):57-60. Yano S, Takehara K, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Fujiwara T, Bouvet M, Hoffman RM. PMID: 28011473.
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    449. Cervical Cancer Patient-Derived Orthotopic Xenograft (PDOX) Is Sensitive to Cisplatinum and Resistant to Nab-paclitaxel. Anticancer Res. 2017 01; 37(1):61-65. Murakami T, Murata T, Kawaguchi K, Kiyuna T, Igarashi K, Hwang HK, Hiroshima Y, Hozumi C, Komatsu S, Kikuchi T, Lwin TM, Delong JC, Miyake K, Zhang Y, Tanaka K, Bouvet M, Endo I, Hoffman RM. PMID: 28011474; PMCID: PMC5831332.
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    450. The disintegrin echistatin in combination with doxorubicin targets high-metastatic human osteosarcoma overexpressing ανβ3 integrin in chick embryo and nude mouse models. Oncotarget. 2016 Dec 27; 7(52):87031-87036. Tome Y, Kimura H, Sugimoto N, Tsuchiya H, Kanaya F, Bouvet M, Hoffman RM. PMID: 27894082; PMCID: PMC5349968.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    451. Tumor-targeting Salmonella typhimurium A1-R combined with temozolomide regresses malignant melanoma with a BRAF-V600E mutation in a patient-derived orthotopic xenograft (PDOX) model. Oncotarget. 2016 Dec 27; 7(52):85929-85936. Kawaguchi K, Igarashi K, Murakami T, Chmielowski B, Kiyuna T, Zhao M, Zhang Y, Singh A, Unno M, Nelson SD, Russell TA, Dry SM, Li Y, Eilber FC, Hoffman RM. PMID: 27835903; PMCID: PMC5349886.
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    452. Tumor-targeting adenovirus OBP-401 inhibits primary and metastatic tumor growth of triple-negative breast cancer in orthotopic nude-mouse models. Oncotarget. 2016 Dec 20; 7(51):85273-85282. Yano S, Takehara K, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 27863373; PMCID: PMC5356735.
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    453. BRCAness and Prognosis in Triple-Negative Breast Cancer Patients Treated with Neoadjuvant Chemotherapy. PLoS One. 2016; 11(12):e0165721. Tanino H, Kosaka Y, Nishimiya H, Tanaka Y, Minatani N, Kikuchi M, Shida A, Waraya M, Katoh H, Enomoto T, Sengoku N, Kajita S, Hoffman RM, Watanabe M. PMID: 27935989; PMCID: PMC5147808.
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    454. In Vivo Selection of Intermediately- and Highly-Malignant Variants of Triple-negative Breast Cancer in Orthotopic Nude Mouse Models. Anticancer Res. 2016 12; 36(12):6273-6277. Yano S, Takehara K, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 27919946.
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    455. Human hair-follicle associated pluripotent (hHAP) stem cells differentiate to cardiac-muscle cells. Cell Cycle. 2017 Jan 02; 16(1):95-99. Tohgi N, Obara K, Yashiro M, Hamada Y, Arakawa N, Mii S, Aki R, Hoffman RM, Amoh Y. PMID: 27880068; PMCID: PMC5270544.
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    456. Efficacy of glycogen synthase kinase-3β targeting against osteosarcoma via activation of β-catenin. Oncotarget. 2016 Nov 22; 7(47):77038-77051. Shimozaki S, Yamamoto N, Domoto T, Nishida H, Hayashi K, Kimura H, Takeuchi A, Miwa S, Igarashi K, Kato T, Aoki Y, Higuchi T, Hirose M, Hoffman RM, Minamoto T, Tsuchiya H. PMID: 27780915; PMCID: PMC5363568.
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    457. Fluorescence-guided surgery of a highly-metastatic variant of human triple-negative breast cancer targeted with a cancer-specific GFP adenovirus prevents recurrence. Oncotarget. 2016 11 15; 7(46):75635-75647. Yano S, Takehara K, Miwa S, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 27689331; PMCID: PMC5342766.
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    458. Patient-derived orthotopic xenograft (PDOX) mouse model of adult rhabdomyosarcoma invades and recurs after resection in contrast to the subcutaneous ectopic model. Cell Cycle. 2017 Jan 02; 16(1):91-94. Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Miwa S, Nelson SD, Dry SM, Li Y, Singh A, Kimura H, Hayashi K, Yamamoto N, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 27830986; PMCID: PMC5270546.
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    459. Patient-derived mouse models of cancer need to be orthotopic in order to evaluate targeted anti-metastatic therapy. Oncotarget. 2016 11 01; 7(44):71696-71702. Hiroshima Y, Maawy A, Zhang Y, Zhang N, Murakami T, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM. PMID: 27765934; PMCID: PMC5342112.
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    460. Vemurafenib-resistant BRAF-V600E-mutated melanoma is regressed by MEK-targeting drug trametinib, but not cobimetinib in a patient-derived orthotopic xenograft (PDOX) mouse model. Oncotarget. 2016 Nov 01; 7(44):71737-71743. Kawaguchi K, Murakami T, Chmielowski B, Igarashi K, Kiyuna T, Unno M, Nelson SD, Russell TA, Dry SM, Li Y, Eilber FC, Hoffman RM. PMID: 27690220; PMCID: PMC5342117.
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    461. Comparison of in vitro invasiveness of high- and low-metastatic triple-negative human breast cancer visualized by color-coded imaging. In Vitro Cell Dev Biol Anim. 2017 Feb; 53(2):96-98. Yano S, Takehara K, Tazawa H, Kishimoto H, Kagawa S, Fujiwara T, Hoffman RM. PMID: 27778228.
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    462. Enhanced Metastatic Recurrence Via Lymphatic Trafficking of a High-Metastatic Variant of Human Triple-Negative Breast Cancer After Surgical Resection in Orthotopic Nude Mouse Models. J Cell Biochem. 2017 03; 118(3):559-569. Yano S, Takehara K, Tazawa H, Kishimoto H, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 27626220.
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    463. Effective fluorescence-guided surgery of liver metastasis using a fluorescent anti-CEA antibody. J Surg Oncol. 2016 Dec; 114(8):951-958. Hiroshima Y, Lwin TM, Murakami T, Mawy AA, Kuniya T, Chishima T, Endo I, Clary BM, Hoffman RM, Bouvet M. PMID: 27696448; PMCID: PMC5565879.
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    464. Hypoxia Enhances Differentiation of Hair Follicle-Associated-Pluripotent (HAP) Stem Cells to Cardiac-Muscle Cells. J Cell Biochem. 2017 03; 118(3):554-558. Shirai K, Hamada Y, Arakawa N, Yamazaki A, Tohgi N, Aki R, Mii S, Hoffman RM, Amoh Y. PMID: 27627796.
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    465. Efficacy of a Cell-Cycle Decoying Killer Adenovirus on 3-D Gelfoam®-Histoculture and Tumor-Sphere Models of Chemo-Resistant Stomach Carcinomatosis Visualized by FUCCI Imaging. PLoS One. 2016; 11(9):e0162991. Yano S, Takehara K, Tazawa H, Kishimoto H, Urata Y, Kagawa S, Fujiwara T, Hoffman RM. PMID: 27673332; PMCID: PMC5038935.
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    466. Fluorescent Orthotopic Mouse Model of Pancreatic Cancer. J Vis Exp. 2016 09 20; (115). Moreno JA, Sanchez A, Hoffman RM, Nur S, Lambros MP. PMID: 27685334; PMCID: PMC5092057.
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    467. Real-Time GFP Intravital Imaging of the Differences in Cellular and Angiogenic Behavior of Subcutaneous and Orthotopic Nude-Mouse Models of Human PC-3 Prostate Cancer. J Cell Biochem. 2016 11; 117(11):2546-51. Zhang Y, Toneri M, Ma H, Yang Z, Bouvet M, Goto Y, Seki N, Hoffman RM. PMID: 27012365.
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    468. Non-toxic Efficacy of the Combination of Caffeine and Valproic Acid on Human Osteosarcoma Cells In Vitro and in Orthotopic Nude-mouse Models. Anticancer Res. 2016 09; 36(9):4477-82. Igarashi K, Yamamoto N, Hayashi K, Takeuchi A, Kimura H, Miwa S, Hoffman RM, Tsuchiya H. PMID: 27630284.
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    469. Color-coded Imaging Enables Fluorescence-guided Surgery to Resect the Tumor Along with the Tumor Microenvironment in a Syngeneic Mouse Model of EL-4 Lymphoma. Anticancer Res. 2016 09; 36(9):4443-8. Hasegawa K, Suetsugu A, Nakamura M, Matsumoto T, Kunisada T, Shimizu M, Saji S, Moriwaki H, Bouvet M, Hoffman RM. PMID: 27630280.
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    470. A Mouse Model of Fluorescent Protein-expressing Disseminated Peritoneal Lymphoma for Fluorescence-guided Surgery. Anticancer Res. 2016 09; 36(9):4483-7. Matsumoto T, Suetsugu A, Hasegawa K, Nakamura M, Shibata Y, Aoki H, Kunisada T, Tsurumi H, Shimizu M, Bouvet M, Hoffman RM. PMID: 27630285.
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    471. Cell-cycle-dependent drug-resistant quiescent cancer cells induce tumor angiogenesis after chemotherapy as visualized by real-time FUCCI imaging. Cell Cycle. 2017 Mar 04; 16(5):406-414. Yano S, Takehara K, Tazawa H, Kishimoto H, Urata Y, Kagawa S, Fujiwara T, Hoffman RM. PMID: 27715464; PMCID: PMC5351920.
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    472. Efficacy of Tumor-Targeting Salmonella A1-R on a Melanoma Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Model. PLoS One. 2016; 11(8):e0160882. Yamamoto M, Zhao M, Hiroshima Y, Zhang Y, Shurell E, Eilber FC, Bouvet M, Noda M, Hoffman RM. PMID: 27500926; PMCID: PMC4976963.
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    473. In Vivo Isolation of a Highly-aggressive Variant of Triple-negative Human Breast Cancer MDA-MB-231 Using Serial Orthotopic Transplantation. Anticancer Res. 2016 Aug; 36(8):3817-20. Yano S, Takehara K, Miwa S, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 27466482.
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    474. Efficacy of the Combination of a PARP Inhibitor and UVC on Cancer Cells as Imaged by Focus Formation by the DNA Repair-related Protein 53BP1 Linked to Green Fluorescent Protein. Anticancer Res. 2016 Aug; 36(8):3821-6. Tome Y, Uehara F, Miwa S, Yano S, Mii S, Efimova EV, Bouvet M, Kimura H, Tsuchiya H, Kanaya F, Hoffman RM. PMID: 27466483.
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    475. Color-coded Live Imaging of Heterokaryon Formation and Nuclear Fusion of Hybridizing Cancer Cells. Anticancer Res. 2016 Aug; 36(8):3827-31. Suetsugu A, Matsumoto T, Hasegawa K, Nakamura M, Kunisada T, Shimizu M, Saji S, Moriwaki H, Bouvet M, Hoffman RM. PMID: 27466484.
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    476. Use of αv Integrin Linked to Green Fluorescent Protein in Osteosarcoma Cells and Confocal Microscopy to Image Molecular Dynamics During Lung Metastasis in Nude Mice. Anticancer Res. 2016 Aug; 36(8):3811-6. Tome Y, Yano S, Sugimoto N, Mii S, Uehara F, Miwa S, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM. PMID: 27466481.
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    477. Effective molecular targeting of CDK4/6 and IGF-1R in a rare FUS-ERG fusion CDKN2A-deletion doxorubicin-resistant Ewing's sarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model. Oncotarget. 2016 Jul 26; 7(30):47556-47564. Murakami T, Singh AS, Kiyuna T, Dry SM, Li Y, James AW, Igarashi K, Kawaguchi K, DeLong JC, Zhang Y, Hiroshima Y, Russell T, Eckardt MA, Yanagawa J, Federman N, Matsuyama R, Chishima T, Tanaka K, Bouvet M, Endo I, Eilber FC, Hoffman RM. PMID: 27286459; PMCID: PMC5216960.
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    478. Disintegrin targeting of an αvβ3 integrin-over-expressing high-metastatic human osteosarcoma with echistatin inhibits cell proliferation, migration, invasion and adhesion in vitro. Oncotarget. 2016 07 19; 7(29):46315-46320. Tome Y, Kimura H, Kiyuna T, Sugimoto N, Tsuchiya H, Kanaya F, Bouvet M, Hoffman RM. PMID: 27331872; PMCID: PMC5216800.
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    479. Early-age-dependent selective decrease of differentiation potential of hair-follicle-associated pluripotent (HAP) stem cells to beating cardiac-muscle cells. Cell Cycle. 2016 Oct; 15(19):2619-2625. Yamazaki A, Hamada Y, Arakawa N, Yashiro M, Mii S, Aki R, Kawahara K, Hoffman RM, Amoh Y. PMID: 27428074; PMCID: PMC5053548.
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    480. Labeling the Stroma of a Patient-Derived Orthotopic Xenograft (PDOX) Mouse Model of Undifferentiated Pleomorphic Soft-Tissue Sarcoma With Red Fluorescent Protein for Rapid Non-Invasive Imaging for Drug Screening. J Cell Biochem. 2017 02; 118(2):361-365. Kiyuna T, Murakami T, Tome Y, Igarashi K, Kawaguchi K, Russell T, Eckardt MA, Crompton J, Singh A, Bernthal N, Bukata S, Federman N, Kanaya F, Eilber FC, Hoffman RM. PMID: 27357060.
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    481. Use of αv Integrin Linked to GFP to Image Molecular Dynamics in Trafficking Cancer-Cell Emboli. J Cell Biochem. 2017 01; 118(1):26-30. Tome Y, Yano S, Sugimoto N, Mii S, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM. PMID: 27191371.
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    482. Solid tumors provide niche-specific conditions that lead to preferential growth of Salmonella. Oncotarget. 2016 Jun 07; 7(23):35169-80. Silva-Valenzuela CA, Desai PT, Molina-Quiroz RC, Pezoa D, Zhang Y, Porwollik S, Zhao M, Hoffman RM, Contreras I, Santiviago CA, McClelland M. PMID: 27145267; PMCID: PMC5085218.
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    483. siRNA Targeting of MDR1 Reverses Multidrug Resistance in a Nude Mouse Model of Doxorubicin-resistant Human Hepatocellular Carcinoma. Anticancer Res. 2016 Jun; 36(6):2675-82. Yang H, Ding R, Tong Z, Huang J, Shen L, Sun YU, Liao J, Yang Z, Hoffman RM, Wang C, Meng X. PMID: 27272776.
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    484. High efficacy of tumor-targeting Salmonella typhimurium A1-R on a doxorubicin- and dactolisib-resistant follicular dendritic-cell sarcoma in a patient-derived orthotopic xenograft PDOX nude mouse model. Oncotarget. 2016 May 31; 7(22):33046-54. Kiyuna T, Murakami T, Tome Y, Kawaguchi K, Igarashi K, Zhang Y, Zhao M, Li Y, Bouvet M, Kanaya F, Singh A, Dry S, Eilber FC, Hoffman RM. PMID: 27105519; PMCID: PMC5078074.
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    485. Tumor-specific cell-cycle decoy by Salmonella typhimurium A1-R combined with tumor-selective cell-cycle trap by methioninase overcome tumor intrinsic chemoresistance as visualized by FUCCI imaging. Cell Cycle. 2016 07 02; 15(13):1715-23. Yano S, Takehara K, Zhao M, Tan Y, Han Q, Li S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 27152859; PMCID: PMC4957602.
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    486. Therapeutic Efficacy of the Traditional Chinese Medicine Baishaoqiwu on TNBS-induced Colitis is Associated with Down-regulation of the TLR4/MyD88/NF-κB Signaling Pathway. In Vivo. 2016 May-Jun; 30(3):181-6. Xu X, Zhang L, Liu Z, Pan Y, Chen D, Yang Z, Deng Q, Cao X, Sun YU, Yang Z, Hoffman RM, Yuan H. PMID: 27107073.
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    487. Bone Marrow Mesenchymal Stem Cells Reverse Liver Damage in a Carbon Tetrachloride-induced Mouse Model of Chronic Liver Injury. In Vivo. 2016 May-Jun; 30(3):187-93. Wang M, Zhang X, Xiong XI, Yang Z, Li P, Wang J, Sun YU, Yang Z, Hoffman RM. PMID: 27107074.
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    488. Imaging Nuclear-Cytoplasmic Dynamics in Primary and Metastatic Colon Cancer in Nude Mice. Anticancer Res. 2016 May; 36(5):2113-7. Hasegawa K, Suetsugu A, Nakamura M, Matsumoto T, Aoki H, Kunisada T, Bouvet M, Shimizu M, Hoffman RM. PMID: 27127111.
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    489. Orthotopic Implantation of Intact Tumor Tissue Leads to Metastasis of OCUM-2MD3 Human Gastric Cancer in Nude Mice Visualized in Real Time by Intravital Fluorescence Imaging. Anticancer Res. 2016 May; 36(5):2125-30. Murakami T, Zhang Y, Wang X, Hiroshima Y, Kasashima H, Yashiro M, Hirakawa K, Miwa A, Kiyuna T, Matsuyama R, Tanaka K, Bouvet M, Endo I, Hoffman RM. PMID: 27127113.
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    490. Blockage of autophagy pathway enhances Salmonella tumor-targeting. Oncotarget. 2016 Apr 19; 7(16):22873-82. Liu B, Jiang Y, Dong T, Zhao M, Wu J, Li L, Chu Y, She S, Zhao H, Hoffman RM, Jia L. PMID: 27013582; PMCID: PMC5008408.
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    491. Real-Time In Vivo Confocal Fluorescence Imaging of Prostate Cancer Bone-Marrow Micrometastasis Development at the Cellular Level in Nude Mice. J Cell Biochem. 2016 11; 117(11):2533-7. Miwa S, Toneri M, Igarashi K, Yano S, Kimura H, Hayashi K, Yamamoto N, Tsuchiya H, Hoffman RM. PMID: 26990763.
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    492. Targeting the insulin growth factor-1 receptor with fluorescent antibodies enables high resolution imaging of human pancreatic cancer in orthotopic mouse models. Oncotarget. 2016 Apr 05; 7(14):18262-8. Park JY, Lee JY, Zhang Y, Hoffman RM, Bouvet M. PMID: 26919100; PMCID: PMC4951286.
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    493. Adenoviral targeting of malignant melanoma for fluorescence-guided surgery prevents recurrence in orthotopic nude-mouse models. Oncotarget. 2016 Apr 05; 7(14):18558-72. Yano S, Takehara K, Kishimoto H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 26701857; PMCID: PMC4951309.
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    494. Modified Liver Hanging Maneuver for En-bloc Right-sided Hepatectomy Combined with Total Caudate Lobectomy for Colon-Cancer Liver Metastasis and Hepatocellular Carcinoma. Anticancer Res. 2016 Apr; 36(4):1729-35. Hiroshima Y, Matsuo K, Kawaguchi D, Kikuchi Y, Endo I, Koda K, Togo S, Hoffman RM, Tanaka K. PMID: 27069152.
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    495. Color-Coded Imaging of Syngeneic Orthotopic Malignant Lymphoma Interacting with Host Stromal Cells During Metastasis. Anticancer Res. 2016 Apr; 36(4):1473-8. Matsumoto T, Suetsugu A, Hasegawa K, Nakamura M, Aoki H, Kunisada T, Tsurumi H, Shimizu M, Hoffman RM. PMID: 27069122.
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    496. Neddylation Inhibition Activates the Extrinsic Apoptosis Pathway through ATF4-CHOP-DR5 Axis in Human Esophageal Cancer Cells. Clin Cancer Res. 2016 Aug 15; 22(16):4145-57. Chen P, Hu T, Liang Y, Li P, Chen X, Zhang J, Ma Y, Hao Q, Wang J, Zhang P, Zhang Y, Zhao H, Yang S, Yu J, Jeong LS, Qi H, Yang M, Hoffman RM, Dong Z, Jia L. PMID: 26983464.
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    497. Tumor-targeting Salmonella typhimurium A1-R in combination with doxorubicin eradicate soft tissue sarcoma in a patient-derived orthotopic xenograft (PDOX) model. Oncotarget. 2016 Mar 15; 7(11):12783-90. Murakami T, DeLong J, Eilber FC, Zhao M, Zhang Y, Zhang N, Singh A, Russell T, Deng S, Reynoso J, Quan C, Hiroshima Y, Matsuyama R, Chishima T, Tanaka K, Bouvet M, Chawla S, Endo I, Hoffman RM. PMID: 26859573; PMCID: PMC4914321.
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    498. Decreased Expression of Tumor-suppressor Gene LKB1 Correlates with Poor Prognosis in Human Gastric Cancer. Anticancer Res. 2016 Mar; 36(3):869-75. Sun J, Ling B, Xu X, Ma R, Li G, Cao X, Ling W, Yang Z, Hoffman RM, Lu J. PMID: 26976973.
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    499. Use of fluorescent proteins and color-coded imaging to visualize cancer cells with different genetic properties. Cancer Metastasis Rev. 2016 Mar; 35(1):5-19. Hoffman RM. PMID: 26942457.
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    500. Tumor relapse prevented by combining adoptive T cell therapy with Salmonella typhimurium. Oncoimmunology. 2016 Jun; 5(6):e1130207. Binder DC, Arina A, Wen F, Tu T, Zhao M, Hoffman RM, Wainwright DA, Schreiber H. PMID: 27471609; PMCID: PMC4938310.
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    501. Improved Resection and Outcome of Colon-Cancer Liver Metastasis with Fluorescence-Guided Surgery Using In Situ GFP Labeling with a Telomerase-Dependent Adenovirus in an Orthotopic Mouse Model. PLoS One. 2016; 11(2):e0148760. Yano S, Takehara K, Miwa S, Kishimoto H, Hiroshima Y, Murakami T, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 26849435; PMCID: PMC4743860.
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    502. Surgical and Oncological Factors Affecting the Successful Engraftment of Patient-derived Xenografts in Pancreatic Ductal Adenocarcinoma. Anticancer Res. 2016 Feb; 36(2):517-21. Jun E, Jung J, Jeong SY, Choi EK, Kim MB, Lee JS, Hong SM, Seol HS, Hwang C, Hoffman RM, Shim IK, Chang S, Kim SC. PMID: 26851005.
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    503. Fluorescence-guided surgery of human prostate cancer experimental bone metastasis in nude mice using anti-CEA DyLight 650 for tumor illumination. J Orthop Res. 2016 Apr; 34(4):559-65. Miwa S, De Magalhães N, Toneri M, Zhang Y, Cao W, Bouvet M, Tsuchiya H, Hoffman RM. PMID: 26135883.
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    504. Analysis of Two Complementary Single-Gene Deletion Mutant Libraries of Salmonella Typhimurium in Intraperitoneal Infection of BALB/c Mice. Front Microbiol. 2015; 6:1455. Silva-Valenzuela CA, Molina-Quiroz RC, Desai P, Valenzuela C, Porwollik S, Zhao M, Hoffman RM, Andrews-Polymenis H, Contreras I, Santiviago CA, McClelland M. PMID: 26779130; PMCID: PMC4700939.
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    505. Fluorescent-Antibody Targeting of Insulin-Like Growth Factor-1 Receptor Visualizes Metastatic Human Colon Cancer in Orthotopic Mouse Models. PLoS One. 2016; 11(1):e0146504. Park JY, Murakami T, Lee JY, Zhang Y, Hoffman RM, Bouvet M. PMID: 26731105; PMCID: PMC4701661.
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    506. Tumor-Targeting Salmonella typhimurium A1-R: An Overview. Methods Mol Biol. 2016; 1409:1-8. Hoffman RM. PMID: 26846797.
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    507. Methods for Tumor Targeting with Salmonella typhimurium A1-R. Methods Mol Biol. 2016; 1409:143-64. Hoffman RM, Zhao M. PMID: 26846809.
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    508. Salmonella typhimurium A1-R and Cell-Cycle Decoy Therapy of Cancer. Methods Mol Biol. 2016; 1409:165-75. Hoffman RM, Yano S. PMID: 26846810.
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    509. Future of Bacterial Therapy of Cancer. Methods Mol Biol. 2016; 1409:177-84. Hoffman RM. PMID: 26846811.
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    510. Cryopreservation of Hair-Follicle Associated Pluripotent (HAP) Stem Cells Maintains Differentiation and Hair-Growth Potential. Adv Exp Med Biol. 2016; 951:191-198. Hoffman RM, Kajiura S, Cao W, Liu F, Amoh Y. PMID: 27837565.
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    511. Isoproterenol directs hair follicle-associated pluripotent (HAP) stem cells to differentiate in vitro to cardiac muscle cells which can be induced to form beating heart-muscle tissue sheets. Cell Cycle. 2016; 15(5):760-5. Yamazaki A, Yashiro M, Mii S, Aki R, Hamada Y, Arakawa N, Kawahara K, Hoffman RM, Amoh Y. PMID: 27104748; PMCID: PMC4845933.
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    512. Introduction to Hair-Follicle-Associated Pluripotent Stem Cells. Methods Mol Biol. 2016; 1453:1-5. Hoffman RM. PMID: 27431240.
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    513. Discovery of HAP Stem Cells. Methods Mol Biol. 2016; 1453:15-20. Li L, Hoffman RM. PMID: 27431242.
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    514. Peripheral-Nerve and Spinal-Cord Regeneration in Mice Using Hair-Follicle-Associated Pluripotent (HAP) Stem Cells. Methods Mol Biol. 2016; 1453:21-32. Amoh Y, Katsuoka K, Hoffman RM. PMID: 27431243.
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    515. Nestin-Expressing Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Promote Whisker Sensory-Nerve Growth in Long-Term 3D-Gelfoam® Histoculture. Methods Mol Biol. 2016; 1453:39-47. Mii S, Duong J, Tome Y, Uchugonova A, Liu F, Amoh Y, Saito N, Katsuoka K, Hoffman RM. PMID: 27431245.
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    516. Protocols for Ectopic Hair Growth from Transplanted Whisker Follicles on the Spinal Cord of Mice. Methods Mol Biol. 2016; 1453:137-44. Cao W, Liu F, Amoh Y, Hoffman RM. PMID: 27431253.
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    517. Protocols for Gelfoam(®) Histoculture of Hair-Shaft-Producing Mouse Whisker Follicles Containing Nestin-GFP-Expressing Hair-Follicle-Associated Pluripotent (HAP) Stem Cells for Long Time Periods. Methods Mol Biol. 2016; 1453:145-50. Cao W, Liu F, Amoh Y, Hoffman RM. PMID: 27431254.
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    518. Protocols for Efficient Differentiation of Hair Follicle-Associated Pluripotent (HAP) Stem Cells to Beating Cardiac Muscle Cells. Methods Mol Biol. 2016; 1453:151-9. Yashiro M, Mii S, Aki R, Hamada Y, Arakawa N, Kawahara K, Hoffman RM, Amoh Y. PMID: 27431255.
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    519. Protocols for Cryopreservation of Intact Hair Follicle That Maintain Pluripotency of Nestin-Expressing Hair-Follicle-Associated Pluripotent (HAP) Stem Cells. Methods Mol Biol. 2016; 1453:173-8. Kajiura S, Mii S, Aki R, Hamada Y, Arakawa N, Kawahara K, Li L, Katsuoka K, Hoffman RM, Amoh Y. PMID: 27431257.
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    520. Aging hair follicles rejuvenated by transplantation to a young subcutaneous environment. Cell Cycle. 2016; 15(8):1093-8. Cao W, Li L, Kajiura S, Amoh Y, Tan Y, Liu F, Hoffman RM. PMID: 26940664; PMCID: PMC4889257.
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    521. Extensive Hair Shaft Growth after Mouse Whisker Follicle Isolation, Cryopreservation and Transplantation in Nude Mice. PLoS One. 2015; 10(12):e0145997. Cao W, Li L, Tran B, Kajiura S, Amoh Y, Liu F, Hoffman RM. PMID: 26716690; PMCID: PMC4696652.
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    522. Imaging the microenvironment of pancreatic cancer patient-derived orthotopic xenografts (PDOX) growing in transgenic nude mice expressing GFP, RFP, or CFP. Cancer Lett. 2016 09 28; 380(1):349-55. Hoffman RM, Bouvet M. PMID: 26742463.
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    523. Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model. Oncotarget. 2015 Dec 08; 6(39):41856-62. Murakami T, Hiroshima Y, Zhao M, Zhang Y, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM. PMID: 26497690; PMCID: PMC4747193.
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    524. Current status and future perspectives of fluorescence-guided surgery for cancer. Expert Rev Anticancer Ther. 2016; 16(1):71-81. DeLong JC, Hoffman RM, Bouvet M. PMID: 26567611; PMCID: PMC5572645.
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    525. Color-Coded Imaging of Breast Cancer Metastatic Niche Formation in Nude Mice. J Cell Biochem. 2015 Dec; 116(12):2730-4. Suetsugu A, Momiyama M, Hiroshima Y, Shimizu M, Saji S, Moriwaki H, Bouvet M, Hoffman RM. PMID: 25981355; PMCID: PMC4600030.
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    526. Prostate Cancer Heterogeneous High-Metastatic Multi-Organ-Colonizing Chemo-Resistant Variants Selected by Serial Metastatic Passage in Nude Mice Are Highly Enriched for Multinucleate Giant Cells. PLoS One. 2015; 10(11):e0140721. Zhang L, Wu C, Hoffman RM. PMID: 26536025; PMCID: PMC4633180.
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    527. Eradication of osteosarcoma by fluorescence-guided surgery with tumor labeling by a killer-reporter adenovirus. J Orthop Res. 2016 05; 34(5):836-44. Yano S, Miwa S, Kishimoto H, Urata Y, Tazawa H, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 26479501.
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    528. Recruitment of Cancer-Associated Fibroblasts and Blood Vessels by Orthotopic Liver Tumors Imaged in Red Fluorescent Protein (RFP) Transgenic Nude Mice. Anticancer Res. 2015 Nov; 35(11):5821-5. Suetsugu A, Hiroshima Y, Matsumoto T, Hasagawa K, Nakamura M, Shimizu M, Saji S, Moriwaki H, Bouvet M, Hoffman RM. PMID: 26504003.
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    529. Real Time Metastatic Route Tracking of Orthotopic PC-3-GFP Human Prostate Cancer Using Intravital Imaging. J Cell Biochem. 2016 Apr; 117(4):1027-32. Zhang Y, Wang X, Hoffman RM, Seki N. PMID: 26515240.
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    530. Therapeutic efficacy of tumor-targeting Salmonella typhimurium A1-R on human colorectal cancer liver metastasis in orthotopic nude-mouse models. Oncotarget. 2015 Oct 13; 6(31):31368-77. Murakami T, Hiroshima Y, Zhao M, Zhang Y, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM. PMID: 26375054; PMCID: PMC4741612.
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    531. Tumor-targeting Salmonella typhimurium A1-R inhibits human prostate cancer experimental bone metastasis in mouse models. Oncotarget. 2015 Oct 13; 6(31):31335-43. Toneri M, Miwa S, Zhang Y, Hu C, Yano S, Matsumoto Y, Bouvet M, Nakanishi H, Hoffman RM, Zhao M. PMID: 26431498; PMCID: PMC4741609.
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    532. Fluorescence-Guided Surgery of Liver Metastasis in Orthotopic Nude-Mouse Models. PLoS One. 2015; 10(10):e0138752. Murakami T, Hiroshima Y, Zhang Y, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM. PMID: 26427050; PMCID: PMC4591295.
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    533. Imaging the Different Mechanisms of Prostate Cancer Cell-killing by Tumor-targeting Salmonella typhimurium A1-R. Anticancer Res. 2015 Oct; 35(10):5225-9. Uchugonova A, Zhang Y, Salz R, Liu F, Suetsugu A, Zhang L, Koenig K, Hoffman RM, Zhao M. PMID: 26408681.
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    534. Extensive Hair-Shaft Elongation by Isolated Mouse Whisker Follicles in Very Long-Term Gelfoam® Histoculture. PLoS One. 2015; 10(9):e0138005. Cao W, Li L, Mii S, Amoh Y, Liu F, Hoffman RM. PMID: 26421923; PMCID: PMC4589329.
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    535. Precise navigation surgery of tumours in the lung in mouse models enabled by in situ fluorescence labelling with a killer-reporter adenovirus. BMJ Open Respir Res. 2015; 2(1):e000096. Yano S, Zhang Y, Miwa S, Kishimoto H, Urata Y, Bouvet M, Kagawa S, Fujiwara T, Hoffman RM. PMID: 26380093; PMCID: PMC4567685.
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    536. A Color-coded Imageable Syngeneic Mouse Model of Stromal-cell Recruitment by Metastatic Lymphoma. Anticancer Res. 2015 Sep; 35(9):4647-54. Matsumoto T, Suetsugu A, Shibata Y, Nakamura N, Aoki H, Kunisada T, Tsurumi H, Shimizu M, Hoffman RM. PMID: 26254354.
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    537. Comparison of GFP-Expressing Imageable Mouse Models of Human Esophageal Squamous Cell Carcinoma Established in Various Anatomical Sites. Anticancer Res. 2015 Sep; 35(9):4655-63. Hu T, Qi H, Li P, Zhao G, Ma Y, Hao Q, Gao C, Zhang Y, Wang C, Yang M, Hoffman RM, Chen P, Dong Z. PMID: 26254355.
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    538. Surgically-Induced Multi-organ Metastasis in an Orthotopic Syngeneic Imageable Model of 4T1 Murine Breast Cancer. Anticancer Res. 2015 Sep; 35(9):4641-6. Zhang Y, Zhang N, Hoffman RM, Zhao M. PMID: 26254353.
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    539. Improved disease-free survival and overall survival after fluorescence-guided surgery of liver metastasis in an orthotopic nude mouse model. J Surg Oncol. 2015 Aug; 112(2):119-24. Murakami T, Hiroshima Y, Zhang Y, Bouvet M, Chishima T, Tanaka K, Endo I, Hoffman RM. PMID: 26266663.
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    540. Long-Term Extensive Ectopic Hair Growth on the Spinal Cord of Mice from Transplanted Whisker Follicles. PLoS One. 2015; 10(8):e0133475. Cao W, Li L, Mii S, Amoh Y, Liu F, Hoffman RM. PMID: 26244638; PMCID: PMC4526646.
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    541. Tumor-Targeting Salmonella typhimurium A1-R Arrests a Chemo-Resistant Patient Soft-Tissue Sarcoma in Nude Mice. PLoS One. 2015; 10(8):e0134324. Hiroshima Y, Zhao M, Zhang Y, Zhang N, Maawy A, Murakami T, Mii S, Uehara F, Yamamoto M, Miwa S, Yano S, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM. PMID: 26237416; PMCID: PMC4523197.
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    542. Patient-derived orthotopic xenografts: better mimic of metastasis than subcutaneous xenografts. Nat Rev Cancer. 2015 08; 15(8):451-2. Hoffman RM. PMID: 26422835.
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    543. Real-time Non-invasive Spectral Imaging of Orthotopic Red Fluorescent Protein-expressing Lung Tumor Growth in Nude Mice. Anticancer Res. 2015 Jul; 35(7):3755-9. Zhang Y, Zhang N, Zhao M, Hoffman RM. PMID: 26124318.
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    544. Comparison of the selective targeting efficacy of Salmonella typhimurium A1-R and VNP20009 on the Lewis lung carcinoma in nude mice. Oncotarget. 2015 Jun 10; 6(16):14625-31. Zhang Y, Zhang N, Zhao M, Hoffman RM. PMID: 25714030; PMCID: PMC4546492.
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    545. Tumor-Targeting Salmonella typhimurium A1-R in Combination with Trastuzumab Eradicates HER-2-Positive Cervical Cancer Cells in Patient-Derived Mouse Models. PLoS One. 2015; 10(6):e0120358. Hiroshima Y, Zhang Y, Zhao M, Zhang N, Murakami T, Maawy A, Mii S, Uehara F, Yamamoto M, Miwa S, Yano S, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM. PMID: 26047477; PMCID: PMC4457918.
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    546. Combination Efficacy of Astragalus membranaceus and Curcuma wenyujin at Different Stages of Tumor Progression in an Imageable Orthotopic Nude Mouse Model of Metastatic Human Ovarian Cancer Expressing Red Fluorescent Protein. Anticancer Res. 2015 Jun; 35(6):3193-207. Yin G, Tang D, Dai J, Liu M, Wu M, Sun YU, Yang Z, Hoffman RM, Li L, Zhang S, Guo X. PMID: 26026079.
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    547. Targeting tumors with a killer-reporter adenovirus for curative fluorescence-guided surgery of soft-tissue sarcoma. Oncotarget. 2015 May 30; 6(15):13133-48. Yano S, Miwa S, Kishimoto H, Uehara F, Tazawa H, Toneri M, Hiroshima Y, Yamamoto M, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 26033451; PMCID: PMC4537004.
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    548. Drug exposure in a metastatic human lung adenocarcinoma cell line gives rise to cells with differing adhesion, proliferation, and gene expression: Implications for cancer chemotherapy. Mol Med Rep. 2015 Sep; 12(3):3236-3242. Li H, He J, Zhong N, Hoffman RM. PMID: 26004767; PMCID: PMC4526089.
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    549. From hair to heart: nestin-expressing hair-follicle-associated pluripotent (HAP) stem cells differentiate to beating cardiac muscle cells. Cell Cycle. 2015; 14(14):2362-6. Yashiro M, Mii S, Aki R, Hamada Y, Arakawa N, Kawahara K, Hoffman RM, Amoh Y. PMID: 25970547; PMCID: PMC4614865.
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    550. Intraperitoneal administration of tumor-targeting Salmonella typhimurium A1-R inhibits disseminated human ovarian cancer and extends survival in nude mice. Oncotarget. 2015 May 10; 6(13):11369-77. Matsumoto Y, Miwa S, Zhang Y, Zhao M, Yano S, Uehara F, Yamamoto M, Hiroshima Y, Toneri M, Bouvet M, Matsubara H, Tsuchiya H, Hoffman RM. PMID: 25957417; PMCID: PMC4484462.
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    551. Imaging the Interaction of Pancreatic Cancer and Stellate Cells in the Tumor Microenvironment during Metastasis. Anticancer Res. 2015 May; 35(5):2545-51. Suetsugu A, Snyder CS, Moriwaki H, Saji S, Bouvet M, Hoffman RM. PMID: 25964528.
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    552. Nanoparticle albumin-bound-paclitaxel: a limited improvement under the current therapeutic paradigm of pancreatic cancer. Expert Opin Pharmacother. 2015 May; 16(7):943-7. Hoffman RM, Bouvet M. PMID: 25887245; PMCID: PMC5559227.
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    553. Toward Curative Fluorescence-Guided Surgery of Pancreatic Cancer. Hepatogastroenterology. 2015 May; 62(139):715-22. Bouvet M, Hoffman RM. PMID: 26897960.
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    554. Early Reporting of Apoptosis by Real-time Imaging of Cancer Cells Labeled with Green Fluorescent Protein in the Nucleus and Red Fluorescent Protein in the Cytoplasm. Anticancer Res. 2015 May; 35(5):2539-43. Yang M, Jiang P, Hoffman RM. PMID: 25964527.
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    555. The Use of Living Cancer Cells Expressing Green Fluorescent Protein in the Nucleus and Red Fluorescence Protein in the Cytoplasm for Real-time Confocal Imaging of Chromosome and Cytoplasmic Dynamics During Mitosis. Anticancer Res. 2015 May; 35(5):2553-7. Suetsugu A, Jiang P, Yang M, Yamamoto N, Moriwaki H, Saji S, Hoffman RM. PMID: 25964529.
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    556. Experimental Curative Fluorescence-guided Surgery of Highly Invasive Glioblastoma Multiforme Selectively Labeled With a Killer-reporter Adenovirus. Mol Ther. 2015 Jul; 23(7):1182-1188. Yano S, Miwa S, Kishimoto H, Toneri M, Hiroshima Y, Yamamoto M, Bouvet M, Urata Y, Tazawa H, Kagawa S, Fujiwara T, Hoffman RM. PMID: 25896244; PMCID: PMC4817790.
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    557. Synergistic inhibition of autophagy and neddylation pathways as a novel therapeutic approach for targeting liver cancer. Oncotarget. 2015 Apr 20; 6(11):9002-17. Chen P, Hu T, Liang Y, Jiang Y, Pan Y, Li C, Zhang P, Wei D, Li P, Jeong LS, Chu Y, Qi H, Yang M, Hoffman RM, Dong Z, Jia L. PMID: 25797246; PMCID: PMC4496198.
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    558. Photoimmunotherapy Inhibits Tumor Recurrence After Surgical Resection on a Pancreatic Cancer Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model. Ann Surg Oncol. 2015 Dec; 22 Suppl 3:S1469-74. Hiroshima Y, Maawy A, Zhang Y, Guzman MG, Heim R, Makings L, Luiken GA, Kobayashi H, Tanaka K, Endo I, Hoffman RM, Bouvet M. PMID: 25893411; PMCID: PMC7711336.
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    559. Cryopreservation of the Hair Follicle Maintains Pluripotency of Nestin-Expressing Hair Follicle-Associated Pluripotent Stem Cells. Tissue Eng Part C Methods. 2015 Aug; 21(8):825-31. Kajiura S, Mii S, Aki R, Hamada Y, Arakawa N, Kawahara K, Li L, Katsuoka K, Hoffman RM, Amoh Y. PMID: 25743086; PMCID: PMC4523096.
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    560. Real-time fluorescence imaging of the DNA damage repair response during mitosis. J Cell Biochem. 2015 Apr; 116(4):661-6. Miwa S, Yano S, Yamamoto M, Matsumoto Y, Uehara F, Hiroshima Y, Toneri M, Murakami T, Kimura H, Hayashi K, Yamamoto N, Efimova EV, Tsuchiya H, Hoffman RM. PMID: 25418288.
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    561. MUC1 selectively targets human pancreatic cancer in orthotopic nude mouse models. PLoS One. 2015; 10(3):e0122100. Park JY, Hiroshima Y, Lee JY, Maawy AA, Hoffman RM, Bouvet M. PMID: 25815753; PMCID: PMC4376872.
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    562. Near infra-red photoimmunotherapy with anti-CEA-IR700 results in extensive tumor lysis and a significant decrease in tumor burden in orthotopic mouse models of pancreatic cancer. PLoS One. 2015; 10(3):e0121989. Maawy AA, Hiroshima Y, Zhang Y, Heim R, Makings L, Garcia-Guzman M, Luiken GA, Kobayashi H, Hoffman RM, Bouvet M. PMID: 25799218; PMCID: PMC4370703.
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    563. Traditional Chinese medicine herbal mixture LQ arrests FUCCI-expressing HeLa cells in G₀/G₁ phase in 2D plastic, 2.5D Matrigel, and 3D Gelfoam culture visualized with FUCCI imaging. Oncotarget. 2015 Mar 10; 6(7):5292-8. Zhang L, Wu C, Bouvet M, Yano S, Hoffman RM. PMID: 25779660; PMCID: PMC4467149.
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    564. Fluorescence-guided surgery, but not bright-light surgery, prevents local recurrence in a pancreatic cancer patient derived orthotopic xenograft (PDOX) model resistant to neoadjuvant chemotherapy (NAC). Pancreatology. 2015 May-Jun; 15(3):295-301. Hiroshima Y, Maawy A, Zhang Y, Murakami T, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Endo I, Hoffman RM, Bouvet M. PMID: 25800176; PMCID: PMC4446223.
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    565. Nestin-expressing hair follicle-accessible pluripotent stem cells for nerve and spinal cord repair. Cells Tissues Organs. 2014; 200(1):42-47. Hoffman RM. PMID: 25766743.
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    566. Fluorescence-guided surgery: it is the cure that matters: in reply to Giorgakis and colleagues. J Am Coll Surg. 2015 Mar; 220(3):377-9. Bouvet M, Hoffman RM. PMID: 25700908.
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    567. Fluorescence-guided surgery of retroperitoneal-implanted human fibrosarcoma in nude mice delays or eliminates tumor recurrence and increases survival compared to bright-light surgery. PLoS One. 2015; 10(2):e0116865. Uehara F, Hiroshima Y, Miwa S, Tome Y, Yano S, Yamamoto M, Matsumoto Y, Maehara H, Tanaka K, Bouvet M, Kanaya F, Hoffman RM. PMID: 25710463; PMCID: PMC4339719.
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    568. Tumor-targeting Salmonella typhimurium A1-R arrests growth of breast-cancer brain metastasis. Oncotarget. 2015 Feb 20; 6(5):2615-22. Zhang Y, Miwa S, Zhang N, Hoffman RM, Zhao M. PMID: 25575815; PMCID: PMC4413605.
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    569. Photoimmunotherapy lowers recurrence after pancreatic cancer surgery in orthotopic nude mouse models. J Surg Res. 2015 Jul; 197(1):5-11. Maawy AA, Hiroshima Y, Zhang Y, Garcia-Guzman M, Luiken GA, Kobayashi H, Hoffman RM, Bouvet M. PMID: 25799527; PMCID: PMC4457622.
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    570. Establishment of a patient-derived orthotopic Xenograft (PDOX) model of HER-2-positive cervical cancer expressing the clinical metastatic pattern. PLoS One. 2015; 10(2):e0117417. Hiroshima Y, Zhang Y, Zhang N, Maawy A, Mii S, Yamamoto M, Uehara F, Miwa S, Yano S, Murakami T, Momiyama M, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Murata T, Endo I, Hoffman RM. PMID: 25689852; PMCID: PMC4331082.
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    571. Application of GFP imaging in cancer. Lab Invest. 2015 Apr; 95(4):432-52. Hoffman RM. PMID: 25686095; PMCID: PMC4383682.
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    572. Complementarity of variable-magnification and spectral-separation fluorescence imaging systems for noninvasive detection of metastasis and intravital detection of single cancer cells in mouse models. Anticancer Res. 2015 Feb; 35(2):661-7. Zhang Y, Hiroshima Y, Ma H, Zhang N, Zhao M, Hoffman RM. PMID: 25667443.
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    573. Patient-derived orthotopic xenograft (PDOX) nude mouse model of soft-tissue sarcoma more closely mimics the patient behavior in contrast to the subcutaneous ectopic model. Anticancer Res. 2015 Feb; 35(2):697-701. Hiroshima Y, Zhang Y, Zhang N, Uehara F, Maawy A, Murakami T, Mii S, Yamamoto M, Miwa S, Yano S, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM. PMID: 25667448.
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    574. Tumor imaging technologies in mouse models. Methods Mol Biol. 2015; 1267:321-48. Bouvet M, Hoffman RM. PMID: 25636477.
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    575. Comparison of label-free and GFP multiphoton imaging of hair follicle-associated pluripotent (HAP) stem cells in mouse whiskers. Cell Cycle. 2015; 14(21):3430-3. Uchugonova A, Cao W, Hoffman RM, Koenig K. PMID: 26397024; PMCID: PMC4825630.
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    576. Back to the Future: Are Tumor-Targeting Bacteria the Next-Generation Cancer Therapy? Methods Mol Biol. 2015; 1317:239-60. Hoffman RM. PMID: 26072411.
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    577. Heterogeneous cell-cycle behavior in response to UVB irradiation by a population of single cancer cells visualized by time-lapse FUCCI imaging. Cell Cycle. 2015; 14(12):1932-7. Miwa S, Yano S, Kimura H, Yamamoto M, Toneri M, Murakami T, Hayashi K, Yamamoto N, Fujiwara T, Tsuchiya H, Hoffman RM. PMID: 25946083; PMCID: PMC4615034.
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    578. Cell-cycle fate-monitoring distinguishes individual chemosensitive and chemoresistant cancer cells in drug-treated heterogeneous populations demonstrated by real-time FUCCI imaging. Cell Cycle. 2015; 14(4):621-9. Miwa S, Yano S, Kimura H, Yamamoto M, Toneri M, Matsumoto Y, Uehara F, Hiroshima Y, Murakami T, Hayashi K, Yamamoto N, Bouvet M, Fujiwara T, Tsuchiya H, Hoffman RM. PMID: 25551170; PMCID: PMC4613186.
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    579. Cancer cells mimic in vivo spatial-temporal cell-cycle phase distribution and chemosensitivity in 3-dimensional Gelfoam® histoculture but not 2-dimensional culture as visualized with real-time FUCCI imaging. Cell Cycle. 2015; 14(6):808-19. Yano S, Miwa S, Mii S, Hiroshima Y, Uehara F, Kishimoto H, Tazawa H, Zhao M, Bouvet M, Fujiwara T, Hoffman RM. PMID: 25564963; PMCID: PMC4614530.
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    580. Inhibition of spontaneous and experimental lung metastasis of soft-tissue sarcoma by tumor-targeting Salmonella typhimurium A1-R. Oncotarget. 2014 Dec 30; 5(24):12849-61. Miwa S, Zhang Y, Baek KE, Uehara F, Yano S, Yamamoto M, Hiroshima Y, Matsumoto Y, Kimura H, Hayashi K, Yamamoto N, Bouvet M, Tsuchiya H, Hoffman RM, Zhao M. PMID: 25528763; PMCID: PMC4350333.
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    581. Biological ablation of sentinel lymph node metastasis in submucosally invaded early gastrointestinal cancer. Mol Ther. 2015 Mar; 23(3):501-9. Kikuchi S, Kishimoto H, Tazawa H, Hashimoto Y, Kuroda S, Nishizaki M, Nagasaka T, Shirakawa Y, Kagawa S, Urata Y, Hoffman RM, Fujiwara T. PMID: 25523761; PMCID: PMC4351467.
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    582. Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models. Oncotarget. 2014 Dec 15; 5(23):12346-57. Hiroshima Y, Zhang Y, Murakami T, Maawy A, Miwa S, Yamamoto M, Yano S, Sato S, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Zhao M, Hoffman RM. PMID: 25402324; PMCID: PMC4322966.
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    583. Development of recombinant methioninase to target the general cancer-specific metabolic defect of methionine dependence: a 40-year odyssey. Expert Opin Biol Ther. 2015 Jan; 15(1):21-31. Hoffman RM. PMID: 25439528.
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    584. Metastatic recurrence in a pancreatic cancer patient derived orthotopic xenograft (PDOX) nude mouse model is inhibited by neoadjuvant chemotherapy in combination with fluorescence-guided surgery with an anti-CA 19-9-conjugated fluorophore. PLoS One. 2014; 9(12):e114310. Hiroshima Y, Maawy A, Zhang Y, Murakami T, Momiyama M, Mori R, Matsuyama R, Katz MH, Fleming JB, Chishima T, Tanaka K, Ichikawa Y, Endo I, Hoffman RM, Bouvet M. PMID: 25463150; PMCID: PMC4252107.
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    585. Independence of cytotoxic drug sensitivity profiles and receptor subtype of invasive ductal breast carcinoma demonstrated by the histoculture drug response assay (HDRA). Anticancer Res. 2014 Dec; 34(12):7197-201. Kim KY, Chung BW, Yang I, Kim MB, Hoffman RM. PMID: 25503149.
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    586. Orthotopic mouse models of tumor metastasis expressing fluorescent reporters produce imageable circulating tumor cells. Cancer Microenviron. 2014 Dec; 7(3):133-8. Hoffman RM. PMID: 25417145; PMCID: PMC4275499.
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    587. Selective efficacy of zoledronic acid on metastasis in a patient-derived orthotopic xenograph (PDOX) nude-mouse model of human pancreatic cancer. J Surg Oncol. 2015 Mar; 111(3):311-5. Hiroshima Y, Maawy AA, Katz MH, Fleming JB, Bouvet M, Endo I, Hoffman RM. PMID: 25394368.
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    588. Efficacy of tumor-targeting Salmonella typhimurium A1-R on nude mouse models of metastatic and disseminated human ovarian cancer. J Cell Biochem. 2014 Nov; 115(11):1996-2003. Matsumoto Y, Miwa S, Zhang Y, Hiroshima Y, Yano S, Uehara F, Yamamoto M, Toneri M, Bouvet M, Matsubara H, Hoffman RM, Zhao M. PMID: 24924355.
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    589. Ratiometric activatable cell-penetrating peptides label pancreatic cancer, enabling fluorescence-guided surgery, which reduces metastases and recurrence in orthotopic mouse models. Ann Surg Oncol. 2015; 22(6):2082-7. Metildi CA, Felsen CN, Savariar EN, Nguyen QT, Kaushal S, Hoffman RM, Tsien RY, Bouvet M. PMID: 25319581; PMCID: PMC4400250.
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    590. Comparison of efficacy and toxicity of traditional Chinese medicine (TCM) herbal mixture LQ and conventional chemotherapy on lung cancer metastasis and survival in mouse models. PLoS One. 2014; 9(10):e109814. Zhang L, Wu C, Zhang Y, Liu F, Wang X, Zhao M, Hoffman RM. PMID: 25286158; PMCID: PMC4186882.
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    591. Comparison of UVB and UVC effects on the DNA damage-response protein 53BP1 in human pancreatic cancer. J Cell Biochem. 2014 Oct; 115(10):1724-8. Uehara F, Miwa S, Tome Y, Hiroshima Y, Yano S, Yamamoto M, Efimova E, Matsumoto Y, Maehara H, Bouvet M, Kanaya F, Hoffman RM. PMID: 24819034.
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    592. Selective methioninase-induced trap of cancer cells in S/G2 phase visualized by FUCCI imaging confers chemosensitivity. Oncotarget. 2014 Sep 30; 5(18):8729-36. Yano S, Li S, Han Q, Tan Y, Bouvet M, Fujiwara T, Hoffman RM. PMID: 25238266; PMCID: PMC4226717.
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    593. Osteosarcoma cells enhance angiogenesis visualized by color-coded imaging in the in vivo Gelfoam® assay. J Cell Biochem. 2014 Sep; 115(9):1490-4. Uehara F, Tome Y, Miwa S, Hiroshima Y, Yano S, Yamamoto M, Mii S, Maehara H, Bouvet M, Kanaya F, Hoffman RM. PMID: 24590470; PMCID: PMC4107116.
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    594. Tumor-targeting Salmonella typhimurium A1-R prevents experimental human breast cancer bone metastasis in nude mice. Oncotarget. 2014 Aug 30; 5(16):7119-25. Miwa S, Yano S, Zhang Y, Matsumoto Y, Uehara F, Yamamoto M, Hiroshima Y, Kimura H, Hayashi K, Yamamoto N, Bouvet M, Tsuchiya H, Hoffman RM, Zhao M. PMID: 25216526; PMCID: PMC4196188.
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    595. In vitro culture and characterization of human lung cancer circulating tumor cells isolated by size exclusion from an orthotopic nude-mouse model expressing fluorescent protein. J Fluoresc. 2014 Sep; 24(5):1531-6. Kolostova K, Zhang Y, Hoffman RM, Bobek V. PMID: 25141982; PMCID: PMC4159578.
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    596. Fluorescence-guided surgery improves outcome in an orthotopic osteosarcoma nude-mouse model. J Orthop Res. 2014 Dec; 32(12):1596-601. Miwa S, Hiroshima Y, Yano S, Zhang Y, Matsumoto Y, Uehara F, Yamamoto M, Kimura H, Hayashi K, Bouvet M, Tsuchiya H, Hoffman RM. PMID: 25138581; PMCID: PMC4198468.
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    597. The tumor-educated-macrophage increase of malignancy of human pancreatic cancer is prevented by zoledronic acid. PLoS One. 2014; 9(8):e103382. Hiroshima Y, Maawy A, Hassanein MK, Menen R, Momiyama M, Murakami T, Miwa S, Yamamoto M, Uehara F, Yano S, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM. PMID: 25116261; PMCID: PMC4130525.
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    598. 3-dimensional tissue is formed from cancer cells in vitro on Gelfoam®, but not on Matrigel™. J Cell Biochem. 2014 Aug; 115(8):1362-7. Tome Y, Uehara F, Mii S, Yano S, Zhang L, Sugimoto N, Maehara H, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM. PMID: 24497277.
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    599. Protein-tyrosine pseudokinase 7 (PTK7) directs cancer cell motility and metastasis. J Biol Chem. 2014 Aug 29; 289(35):24238-49. Golubkov VS, Prigozhina NL, Zhang Y, Stoletov K, Lewis JD, Schwartz PE, Hoffman RM, Strongin AY. PMID: 25006253; PMCID: PMC4148854.
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    600. Methods for the development of tumor-targeting bacteria. Expert Opin Drug Discov. 2014 Jul; 9(7):741-50. Hoffman RM, Zhao M. PMID: 24949888.
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    601. Efficacy of Salmonella typhimurium A1-R versus chemotherapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX). J Cell Biochem. 2014 Jul; 115(7):1254-61. Hiroshima Y, Zhao M, Maawy A, Zhang Y, Katz MH, Fleming JB, Uehara F, Miwa S, Yano S, Momiyama M, Suetsugu A, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM. PMID: 24435915.
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    602. Specificity of lectin-immobilized fluorescent nanospheres for colorectal tumors in a mouse model which better resembles the clinical disease. Contrast Media Mol Imaging. 2015 Mar-Apr; 10(2):135-43. Kitamura T, Sakuma S, Shimosato M, Higashino H, Masaoka Y, Kataoka M, Yamashita S, Hiwatari K, Kumagai H, Morimoto N, Koike S, Tobita E, Hoffman RM, Gore JC, Pham W. PMID: 24976331; PMCID: PMC4277738.
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    603. Fluorescence-guided surgery in combination with UVC irradiation cures metastatic human pancreatic cancer in orthotopic mouse models. PLoS One. 2014; 9(6):e99977. Hiroshima Y, Maawy A, Zhang Y, Sato S, Murakami T, Yamamoto M, Uehara F, Miwa S, Yano S, Momiyama M, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM. PMID: 24924955; PMCID: PMC4055701.
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    604. Comparison of nestin-expressing multipotent stem cells in the tongue fungiform papilla and vibrissa hair follicle. J Cell Biochem. 2014 Jun; 115(6):1070-6. Mii S, Amoh Y, Katsuoka K, Hoffman RM. PMID: 24142339.
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    605. Fluorescence-guided surgery of prostate cancer bone metastasis. J Surg Res. 2014 Nov; 192(1):124-33. Miwa S, Matsumoto Y, Hiroshima Y, Yano S, Uehara F, Yamamoto M, Zhang Y, Kimura H, Hayashi K, Yamamoto N, Bouvet M, Sugimoto N, Tsuchiya H, Hoffman RM. PMID: 24972740.
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    606. Polyethylene glycol (PEG) linked to near infrared (NIR) dyes conjugated to chimeric anti-carcinoembryonic antigen (CEA) antibody enhances imaging of liver metastases in a nude-mouse model of human colon cancer. PLoS One. 2014; 9(5):e97965. Maawy AA, Hiroshima Y, Zhang Y, Luiken GA, Hoffman RM, Bouvet M. PMID: 24859320; PMCID: PMC4032229.
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    607. Overactivated neddylation pathway as a therapeutic target in lung cancer. J Natl Cancer Inst. 2014 Jun; 106(6):dju083. Li L, Wang M, Yu G, Chen P, Li H, Wei D, Zhu J, Xie L, Jia H, Shi J, Li C, Yao W, Wang Y, Gao Q, Jeong LS, Lee HW, Yu J, Hu F, Mei J, Wang P, Chu Y, Qi H, Yang M, Dong Z, Sun Y, Hoffman RM, Jia L. PMID: 24853380.
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    608. Spatial-temporal FUCCI imaging of each cell in a tumor demonstrates locational dependence of cell cycle dynamics and chemoresponsiveness. Cell Cycle. 2014; 13(13):2110-9. Yano S, Zhang Y, Miwa S, Tome Y, Hiroshima Y, Uehara F, Yamamoto M, Suetsugu A, Kishimoto H, Tazawa H, Zhao M, Bouvet M, Fujiwara T, Hoffman RM. PMID: 24811200; PMCID: PMC4111702.
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    609. Advantages of fluorescence-guided laparoscopic surgery of pancreatic cancer labeled with fluorescent anti-carcinoembryonic antigen antibodies in an orthotopic mouse model. J Am Coll Surg. 2014 Jul; 219(1):132-41. Metildi CA, Kaushal S, Luiken GA, Hoffman RM, Bouvet M. PMID: 24768506; PMCID: PMC4065820.
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    610. Color-coded fluorescence imaging of lymph-node metastasis, angiogenesis, and its drug-induced inhibition. J Cell Biochem. 2014 Mar; 115(3):457-63. Aki R, Amoh Y, Bouvet M, Katsuoka K, Hoffman RM. PMID: 24115019.
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    611. Fluorescence-guided surgery with a fluorophore-conjugated antibody to carcinoembryonic antigen (CEA), that highlights the tumor, improves surgical resection and increases survival in orthotopic mouse models of human pancreatic cancer. Ann Surg Oncol. 2014 Apr; 21(4):1405-11. Metildi CA, Kaushal S, Pu M, Messer KA, Luiken GA, Moossa AR, Hoffman RM, Bouvet M. PMID: 24499827; PMCID: PMC4334378.
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    612. Successful fluorescence-guided surgery on human colon cancer patient-derived orthotopic xenograft mouse models using a fluorophore-conjugated anti-CEA antibody and a portable imaging system. J Laparoendosc Adv Surg Tech A. 2014 Apr; 24(4):241-7. Hiroshima Y, Maawy A, Metildi CA, Zhang Y, Uehara F, Miwa S, Yano S, Sato S, Murakami T, Momiyama M, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM. PMID: 24494971; PMCID: PMC4047993.
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    613. Parathyroid hormone related-protein promotes epithelial-to-mesenchymal transition in prostate cancer. PLoS One. 2014; 9(1):e85803. Ongkeko WM, Burton D, Kiang A, Abhold E, Kuo SZ, Rahimy E, Yang M, Hoffman RM, Wang-Rodriguez J, Deftos LJ. PMID: 24465715; PMCID: PMC3899059.
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    614. Invading cancer cells are predominantly in G0/G1 resulting in chemoresistance demonstrated by real-time FUCCI imaging. Cell Cycle. 2014; 13(6):953-60. Yano S, Miwa S, Mii S, Hiroshima Y, Uehara F, Yamamoto M, Kishimoto H, Tazawa H, Bouvet M, Fujiwara T, Hoffman RM. PMID: 24552821; PMCID: PMC3984318.
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    615. Imaging metastatic cell trafficking at the cellular level in vivo with fluorescent proteins. Methods Mol Biol. 2014; 1070:171-9. Hoffman RM. PMID: 24092439.
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    616. Tumor-targeting Salmonella typhimurium A1-R decoys quiescent cancer cells to cycle as visualized by FUCCI imaging and become sensitive to chemotherapy. Cell Cycle. 2014; 13(24):3958-63. Yano S, Zhang Y, Zhao M, Hiroshima Y, Miwa S, Uehara F, Kishimoto H, Tazawa H, Bouvet M, Fujiwara T, Hoffman RM. PMID: 25483077; PMCID: PMC4615054.
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    617. Imageable clinically relevant mouse models of metastasis. Methods Mol Biol. 2014; 1070:141-70. Hoffman RM. PMID: 24092438.
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    618. Specific tumor labeling enhanced by polyethylene glycol linkage of near infrared dyes conjugated to a chimeric anti-carcinoembryonic antigen antibody in a nude mouse model of human pancreatic cancer. J Biomed Opt. 2014; 19(10):101504. Maawy AA, Hiroshima Y, Zhang Y, Luiken GA, Hoffman RM, Bouvet M. PMID: 24887695; PMCID: PMC4160999.
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    619. Transgenic nude mice ubiquitously expressing fluorescent proteins for color-coded imaging of the tumor microenvironment. Methods Mol Biol. 2014; 1194:353-65. Hoffman RM. PMID: 25064114.
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    620. Fluorescent angiogenesis models using gelfoam® implanted in transgenic mice expressing fluorescent proteins. Methods Mol Biol. 2014; 1135:213-22. Hoffman RM. PMID: 24510867.
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    621. Comparison of a chimeric anti-carcinoembryonic antigen antibody conjugated with visible or near-infrared fluorescent dyes for imaging pancreatic cancer in orthotopic nude mouse models. J Biomed Opt. 2013 Dec; 18(12):126016. Maawy AA, Hiroshima Y, Kaushal S, Luiken GA, Hoffman RM, Bouvet M. PMID: 24356647; PMCID: PMC3868446.
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    622. Hand-held high-resolution fluorescence imaging system for fluorescence-guided surgery of patient and cell-line pancreatic tumors growing orthotopically in nude mice. J Surg Res. 2014 Apr; 187(2):510-7. Hiroshima Y, Maawy A, Sato S, Murakami T, Uehara F, Miwa S, Yano S, Momiyama M, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM. PMID: 24373959; PMCID: PMC3959586.
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    623. Fluorescently labeled chimeric anti-CEA antibody improves detection and resection of human colon cancer in a patient-derived orthotopic xenograft (PDOX) nude mouse model. J Surg Oncol. 2014 Apr; 109(5):451-8. Metildi CA, Kaushal S, Luiken GA, Talamini MA, Hoffman RM, Bouvet M. PMID: 24249594; PMCID: PMC3962702.
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    624. Development of a clinically-precise mouse model of rectal cancer. PLoS One. 2013; 8(11):e79453. Kishimoto H, Momiyama M, Aki R, Kimura H, Suetsugu A, Bouvet M, Fujiwara T, Hoffman RM. PMID: 24265772; PMCID: PMC3827128.
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    625. Dynamic color-coded fluorescence imaging of the cell-cycle phase, mitosis, and apoptosis demonstrates how caffeine modulates cisplatinum efficacy. J Cell Biochem. 2013 Nov; 114(11):2454-60. Miwa S, Yano S, Tome Y, Sugimoto N, Hiroshima Y, Uehara F, Mii S, Kimura H, Hayashi K, Efimova EV, Fujiwara T, Tsuchiya H, Hoffman RM. PMID: 23696238.
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    626. Imaging UVC-induced DNA damage response in models of minimal cancer. J Cell Biochem. 2013 Nov; 114(11):2493-9. Miwa S, Yano S, Hiroshima Y, Tome Y, Uehara F, Mii S, Efimova EV, Kimura H, Hayashi K, Tsuchiya H, Hoffman RM. PMID: 23744630.
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    627. Nestin-expressing stem cells from the hair follicle can differentiate into motor neurons and reduce muscle atrophy after transplantation to injured nerves. Tissue Eng Part A. 2014 Feb; 20(3-4):656-62. Liu F, Zhang C, Hoffman RM. PMID: 24020586; PMCID: PMC3927650.
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    628. Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell. 2013 Oct 10; 155(2):384-96. He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M. PMID: 24120137; PMCID: PMC4015514.
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    629. Imaging nuclear - cytoplasm dynamics of cancer cells in the intravascular niche of live mice. Anticancer Res. 2013 Oct; 33(10):4229-36. Suetsugu A, Jiang P, Moriwaki H, Saji S, Bouvet M, Hoffman RM. PMID: 24122986.
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    630. A genetically engineered oncolytic adenovirus decoys and lethally traps quiescent cancer stem-like cells in S/G2/M phases. Clin Cancer Res. 2013 Dec 01; 19(23):6495-505. Yano S, Tazawa H, Hashimoto Y, Shirakawa Y, Kuroda S, Nishizaki M, Kishimoto H, Uno F, Nagasaka T, Urata Y, Kagawa S, Hoffman RM, Fujiwara T. PMID: 24081978.
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    631. High lung-metastatic variant of human osteosarcoma cells, selected by passage of lung metastasis in nude mice, is associated with increased expression of α(v)β(3) integrin. Anticancer Res. 2013 Sep; 33(9):3623-7. Tome Y, Kimura H, Maehara H, Sugimoto N, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM. PMID: 24023288.
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    632. Efficacy comparison of traditional Chinese medicine LQ versus gemcitabine in a mouse model of pancreatic cancer. J Cell Biochem. 2013 Sep; 114(9):2131-7. Zhang L, Wu C, Zhang Y, Liu F, Zhao M, Bouvet M, Hoffman RM. PMID: 23553901.
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    633. In vivo fluorescence imaging of gastrointestinal stromal tumors using fluorophore-conjugated anti-KIT antibody. Ann Surg Oncol. 2013 Dec; 20 Suppl 3:S693-700. Metildi CA, Tang CM, Kaushal S, Leonard SY, Magistri P, Tran Cao HS, Hoffman RM, Bouvet M, Sicklick JK. PMID: 23943029; PMCID: PMC4127988.
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    634. Comparison of efficacy of Salmonella typhimurium A1-R and chemotherapy on stem-like and non-stem human pancreatic cancer cells. Cell Cycle. 2013 Sep 01; 12(17):2774-80. Hiroshima Y, Zhao M, Zhang Y, Maawy A, Hassanein MK, Uehara F, Miwa S, Yano S, Momiyama M, Suetsugu A, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM. PMID: 23966167; PMCID: PMC3899191.
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    635. A dual-color genetically engineered mouse model for multispectral imaging of the pancreatic microenvironment. Pancreas. 2013 Aug; 42(6):952-8. Snyder CS, Harrington AR, Kaushal S, Mose E, Lowy AM, Hoffman RM, Bouvet M. PMID: 23648841; PMCID: PMC3713119.
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    636. Real-time imaging of αv integrin molecular dynamics in osteosarcoma cells in vitro and in vivo. Anticancer Res. 2013 Aug; 33(8):3021-5. Tome Y, Sugimoto N, Yano S, Momiyama M, Mii S, Maehara H, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM. PMID: 23898055.
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    637. Color-coded imaging of spontaneous vessel anastomosis in vivo. Anticancer Res. 2013 Aug; 33(8):3041-5. Uehara F, Tome Y, Reynoso J, Mii S, Yano S, Miwa S, Bouvet M, Maehara H, Kanaya F, Moossa AR, Hoffman RM. PMID: 23898058.
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    638. Antigen-specific bacterial vaccine combined with anti-PD-L1 rescues dysfunctional endogenous T cells to reject long-established cancer. Cancer Immunol Res. 2013 Aug; 1(2):123-33. Binder DC, Engels B, Arina A, Yu P, Slauch JM, Fu YX, Karrison T, Burnette B, Idel C, Zhao M, Hoffman RM, Munn DH, Rowley DA, Schreiber H. PMID: 24455752; PMCID: PMC3895468.
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    639. Specific route mapping visualized with GFP of single-file streaming contralateral and systemic metastasis of Lewis lung carcinoma cells beginning within hours of orthotopic implantation [correction of implantion]. J Cell Biochem. 2013 Aug; 114(8):1738-43. Rashidi B, Moossa AR, Hoffman RM. PMID: 23444111.
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    640. In vivo fluorescence imaging reveals the promotion of mammary tumorigenesis by mesenchymal stromal cells. PLoS One. 2013; 8(7):e69658. Ke CC, Liu RS, Suetsugu A, Kimura H, Ho JH, Lee OK, Hoffman RM. PMID: 23936067; PMCID: PMC3723858.
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    641. Tumor growth control with IDO-silencing Salmonella--letter. Cancer Res. 2013 Jul 15; 73(14):4591. Hoffman RM. PMID: 23832662.
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    642. The role of hair follicle nestin-expressing stem cells during whisker sensory-nerve growth in long-term 3D culture. J Cell Biochem. 2013 Jul; 114(7):1674-84. Mii S, Duong J, Tome Y, Uchugonova A, Liu F, Amoh Y, Saito N, Katsuoka K, Hoffman RM. PMID: 23444061.
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    643. Nestin-Expressing Stem Cells Promote Nerve Growth in Long-Term 3-Dimensional Gelfoam®-Supported Histoculture. PLoS One. 2013; 8(6):e67153. Mii S, Uehara F, Yano S, Tran B, Miwa S, Hiroshima Y, Amoh Y, Katsuoka K, Hoffman RM. PMID: 23840607; PMCID: PMC3686756.
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    644. Ovarian tumor attachment, invasion, and vascularization reflect unique microenvironments in the peritoneum: insights from xenograft and mathematical models. Front Oncol. 2013; 3:97. Steinkamp MP, Winner KK, Davies S, Muller C, Zhang Y, Hoffman RM, Shirinifard A, Moses M, Jiang Y, Wilson BS. PMID: 23730620; PMCID: PMC3656359.
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    645. Salmonella typhimurium A1-R tumor targeting in immunocompetent mice is enhanced by a traditional Chinese medicine herbal mixture. Anticancer Res. 2013 May; 33(5):1837-43. Zhang Y, Zhang N, Su S, Hoffman RM, Zhao M. PMID: 23645728.
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    646. Paclitaxel nanosuspensions for targeted chemotherapy - nanosuspension preparation, characterization, and use. Pharm Dev Technol. 2014 Jun; 19(4):438-53. Lee SE, Bairstow SF, Werling JO, Chaubal MV, Lin L, Murphy MA, DiOrio JP, Gass J, Rabinow B, Wang X, Zhang Y, Yang Z, Hoffman RM. PMID: 23617261.
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    647. In vivo serial selection of human pancreatic cancer cells in orthotopic mouse models produces high metastatic variants irrespective of Kras status. J Surg Res. 2013 Sep; 184(1):290-8. Metildi CA, Kaushal S, Hoffman RM, Bouvet M. PMID: 23590868; PMCID: PMC3724759.
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    648. Dynamic subcellular imaging of cancer cell mitosis in the brain of live mice. Anticancer Res. 2013 Apr; 33(4):1367-71. Momiyama M, Suetsugu A, Kimura H, Chishima T, Bouvet M, Endo I, Hoffman RM. PMID: 23564774.
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    649. Single cell time-lapse imaging of focus formation by the DNA damage-response protein 53BP1 after UVC irradiation of human pancreatic cancer cells. Anticancer Res. 2013 Apr; 33(4):1373-7. Miwa S, Tome Y, Yano S, Hiroshima Y, Uehara F, Mii S, Kimura H, Hayashi K, Tsuchiya H, Bouvet M, Efimova EV, Hoffman RM. PMID: 23564775.
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    650. A color-coded imaging model of the interaction of αv integrin-GFP expressed in osteosarcoma cells and RFP expressing blood vessels in Gelfoam® vascularized in vivo. Anticancer Res. 2013 Apr; 33(4):1361-6. Uehara F, Tome Y, Yano S, Miwa S, Mii S, Hiroshima Y, Bouvet M, Maehara H, Kanaya F, Hoffman RM. PMID: 23564773.
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    651. Progression-free survival is accurately predicted in patients treated with chemotherapy for epithelial ovarian cancer by the histoculture drug response assay in a prospective correlative clinical trial at a single institution. Anticancer Res. 2013 Mar; 33(3):1029-34. Jung PS, Kim DY, Kim MB, Lee SW, Kim JH, Kim YM, Kim YT, Hoffman RM, Nam JH. PMID: 23482777.
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    652. Fluorescence-guided surgery and fluorescence laparoscopy for gastrointestinal cancers in clinically-relevant mouse models. Gastroenterol Res Pract. 2013; 2013:290634. Metildi CA, Hoffman RM, Bouvet M. PMID: 23533387; PMCID: PMC3590746.
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    653. Intraoperative imaging of metastatic lymph nodes using a fluorophore-conjugated antibody in a HER2/neu-expressing orthotopic breast cancer mouse model. Anticancer Res. 2013 Feb; 33(2):419-24. Wu J, Ma R, Cao H, Wang Z, Jing C, Sun Y, Zhang Y, Yang Z, Hoffman RM, Tang J. PMID: 23393332.
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    654. Imaging the efficacy of UVC irradiation on superficial brain tumors and metastasis in live mice at the subcellular level. J Cell Biochem. 2013 Feb; 114(2):428-34. Momiyama M, Suetsugu A, Kimura H, Kishimoto H, Aki R, Yamada A, Sakurada H, Chishima T, Bouvet M, Endo I, Hoffman RM. PMID: 22961687.
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    655. VEGF-C ShRNA inhibits pancreatic cancer growth and lymphangiogenesis in an orthotopic fluorescent nude mouse model. Anticancer Res. 2013 Feb; 33(2):409-17. Shi Y, Tong M, Wu Y, Yang Z, Hoffman RM, Zhang Y, Tian Y, Qi M, Lin Y, Liu Y, Dai L, Sun Y, Wang Z. PMID: 23393331.
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    656. Role of connexins in metastatic breast cancer and melanoma brain colonization. J Cell Sci. 2013 Feb 15; 126(Pt 4):904-13. Stoletov K, Strnadel J, Zardouzian E, Momiyama M, Park FD, Kelber JA, Pizzo DP, Hoffman R, VandenBerg SR, Klemke RL. PMID: 23321642; PMCID: PMC3625812.
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    657. Multiphoton tomography visualizes collagen fibers in the tumor microenvironment that maintain cancer-cell anchorage and shape. J Cell Biochem. 2013 Jan; 114(1):99-102. Uchugonova A, Zhao M, Weinigel M, Zhang Y, Bouvet M, Hoffman RM, König K. PMID: 22886742.
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    658. Subcellular real-time imaging of the efficacy of temozolomide on cancer cells in the brain of live mice. Anticancer Res. 2013 Jan; 33(1):103-6. Momiyama M, Suetsugu A, Chishima T, Bouvet M, Endo I, Hoffman RM. PMID: 23267133.
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    659. Primer dosing of S. typhimurium A1-R potentiates tumor-targeting and efficacy in immunocompetent mice. Anticancer Res. 2013 Jan; 33(1):97-102. Tome Y, Zhang Y, Momiyama M, Maehara H, Kanaya F, Tomita K, Tsuchiya H, Bouvet M, Hoffman RM, Zhao M. PMID: 23267132.
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    660. Enhanced resection of orthotopic red-fluorescent-protein-expressing human glioma by fluorescence-guided surgery in nude mice. Anticancer Res. 2013 Jan; 33(1):107-11. Momiyama M, Hiroshima Y, Suetsugu A, Tome Y, Mii S, Yano S, Bouvet M, Chishima T, Endo I, Hoffman RM. PMID: 23267134.
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    661. Fluorescent proteins as visible in vivo sensors. Prog Mol Biol Transl Sci. 2013; 113:389-402. Hoffman RM. PMID: 23244796.
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    662. Involvement of CXCR4 chemokine receptor in metastastic HER2-positive esophageal cancer. PLoS One. 2012; 7(10):e47287. Gros SJ, Kurschat N, Drenckhan A, Dohrmann T, Forberich E, Effenberger K, Reichelt U, Hoffman RM, Pantel K, Kaifi JT, Izbicki JR. PMID: 23082154; PMCID: PMC3474831.
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    663. Fluorescent proteins enhance UVC PDT of cancer cells. Anticancer Res. 2012 Oct; 32(10):4327-30. Momiyama M, Suetsugu A, Kimura H, Kishimoto H, Aki R, Yamada A, Sakurada H, Chishima T, Bouvet M, Bulgakova NN, Endo I, Hoffman RM. PMID: 23060554.
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    664. Cancer-cell killing by engineered Salmonella imaged by multiphoton tomography in live mice. Anticancer Res. 2012 Oct; 32(10):4331-7. Uchugonova A, Zhao M, Zhang Y, Weinigel M, König K, Hoffman RM. PMID: 23060555.
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    665. Fluorescence-guided surgery of human colon cancer increases complete resection resulting in cures in an orthotopic nude mouse model. J Surg Res. 2013 Jan; 179(1):87-93. Metildi CA, Kaushal S, Snyder CS, Hoffman RM, Bouvet M. PMID: 23079571; PMCID: PMC3518733.
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    666. Detection of colon cancer metastases with fluorescence laparoscopy in orthotopic nude mouse models. Arch Surg. 2012 Sep; 147(9):876-80. Menen RS, Kaushal S, Snyder CS, Talamini MA, Hoffman RM, Bouvet M. PMID: 22987187.
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    667. Tumor-specific fluorescence antibody imaging enables accurate staging laparoscopy in an orthotopic model of pancreatic cancer. Hepatogastroenterology. 2012 Sep; 59(118):1994-9. Tran Cao HS, Kaushal S, Metildi CA, Menen RS, Lee C, Snyder CS, Messer K, Pu M, Luiken GA, Talamini MA, Hoffman RM, Bouvet M. PMID: 22369743; PMCID: PMC4096574.
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    668. Multipotent nestin-expressing stem cells capable of forming neurons are located in the upper, middle and lower part of the vibrissa hair follicle. Cell Cycle. 2012 Sep 15; 11(18):3513-7. Amoh Y, Mii S, Aki R, Hamada Y, Kawahara K, Hoffman RM, Katsuoka K. PMID: 22918245; PMCID: PMC3466560.
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    669. Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models. Adv Drug Deliv Rev. 2013 Mar; 65(3):383-90. Suetsugu A, Honma K, Saji S, Moriwaki H, Ochiya T, Hoffman RM. PMID: 22921594.
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    670. Non-invasive fluorescent-protein imaging of orthotopic pancreatic-cancer-patient tumorgraft progression in nude mice. Anticancer Res. 2012 Aug; 32(8):3063-7. Suetsugu A, Katz M, Fleming J, Truty M, Thomas R, Saji S, Moriwaki H, Bouvet M, Hoffman RM. PMID: 22843874.
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    671. The challenges posed by cancer heterogeneity. Nat Biotechnol. 2012 Jul 10; 30(7):604-10. Bhatia S, Frangioni JV, Hoffman RM, Iafrate AJ, Polyak K. PMID: 22781679.
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    672. Real-time imaging of apoptosis induction of human breast cancer cells by the traditional Chinese medicinal herb tubeimu. Anticancer Res. 2012 Jul; 32(7):2509-14. Hu M, Zhao M, An C, Yang M, Li Q, Zhang Y, Suetsugu A, Tome Y, Yano S, Fu Y, Hoffman RM, Hu K. PMID: 22753707.
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    673. Comparative chemosensitivity of circulating human prostate cancer cells and primary cancer cells. Anticancer Res. 2012 Jul; 32(7):2881-4. Menen R, Zhao M, Zhang L, Hassanein MK, Bobek V, Kolostova K, Bouvet M, Hoffman RM. PMID: 22753751.
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    674. Bugging tumors. Cancer Discov. 2012 Jul; 2(7):588-90. Hoffman RM. PMID: 22787089; PMCID: PMC3706103.
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    675. Tumor-educated macrophages promote tumor growth and peritoneal metastasis in an orthotopic nude mouse model of human pancreatic cancer. In Vivo. 2012 Jul-Aug; 26(4):565-9. Menen RS, Hassanein MK, Momiyama M, Suetsugu A, Moossa AR, Hoffman RM, Bouvet M. PMID: 22773569.
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    676. Determination of the optimal route of administration of Salmonella typhimurium A1-R to target breast cancer in nude mice. Anticancer Res. 2012 Jul; 32(7):2501-8. Zhang Y, Tome Y, Suetsugu A, Zhang L, Zhang N, Hoffman RM, Zhao M. PMID: 22753706.
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    677. Multi-color palette of fluorescent proteins for imaging the tumor microenvironment of orthotopic tumorgraft mouse models of clinical pancreatic cancer specimens. J Cell Biochem. 2012 Jul; 113(7):2290-5. Suetsugu A, Katz M, Fleming J, Truty M, Thomas R, Moriwaki H, Bouvet M, Saji S, Hoffman RM. PMID: 22573550; PMCID: PMC3566777.
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    678. Fluorescence-guided surgery allows for more complete resection of pancreatic cancer, resulting in longer disease-free survival compared with standard surgery in orthotopic mouse models. J Am Coll Surg. 2012 Jul; 215(1):126-35; discussion 135-6. Metildi CA, Kaushal S, Hardamon CR, Snyder CS, Pu M, Messer KS, Talamini MA, Hoffman RM, Bouvet M. PMID: 22632917; PMCID: PMC3383387.
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    679. KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer. Cancer Res. 2012 May 15; 72(10):2554-64. Kelber JA, Reno T, Kaushal S, Metildi C, Wright T, Stoletov K, Weems JM, Park FD, Mose E, Wang Y, Hoffman RM, Lowy AM, Bouvet M, Klemke RL. PMID: 22589274; PMCID: PMC3366503.
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    680. Real-time confocal imaging of trafficking of nestin-expressing multipotent stem cells in mouse whiskers in long-term 3-D histoculture. In Vitro Cell Dev Biol Anim. 2012 May; 48(5):301-5. Duong J, Mii S, Uchugonova A, Liu F, Moossa AR, Hoffman RM. PMID: 22580909.
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    681. Inhibition of metastasis of circulating human prostate cancer cells in the chick embryo by an extracellular matrix produced by foreskin fibroblasts in culture. Anticancer Res. 2012 May; 32(5):1573-7. Menen R, Pinney E, Hassanein MK, Kolostova K, Bobek V, Suetsugu A, Zhang N, Bouvet M, Naughton GK, Hoffman RM. PMID: 22593434.
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    682. High accuracy of mesoscopic epi-fluorescence tomography for non-invasive quantitative volume determination of fluorescent protein-expressing tumours in mice. Eur Radiol. 2012 Sep; 22(9):1955-62. Abou-Elkacem L, Björn S, Doleschel D, Ntziachristos V, Schulz R, Hoffman RM, Kiessling F, Lederle W. PMID: 22544295.
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    683. An LED light source and novel fluorophore combinations improve fluorescence laparoscopic detection of metastatic pancreatic cancer in orthotopic mouse models. J Am Coll Surg. 2012 Jun; 214(6):997-1007.e2. Metildi CA, Kaushal S, Lee C, Hardamon CR, Snyder CS, Luiken GA, Talamini MA, Hoffman RM, Bouvet M. PMID: 22542065; PMCID: PMC3360832.
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    684. Site-specific cytomorphology of disseminated PC-3 prostate cancer cells visualized in vivo with fluorescent proteins. Diagn Cytopathol. 2013 May; 41(5):413-7. Bobek V, Hoffman RM, Kolostova K. PMID: 22508666.
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    685. Efficacy of the Chinese traditional medicinal herb Celastrus orbiculatus Thunb on human hepatocellular carcinoma in an orthothopic fluorescent nude mouse model. Anticancer Res. 2012 Apr; 32(4):1213-20. Wang M, Zhang X, Xiong X, Yang Z, Sun Y, Yang Z, Hoffman RM, Liu Y. PMID: 22493351.
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    686. Imageable fluorescent metastasis resulting in transgenic GFP mice orthotopically implanted with human-patient primary pancreatic cancer specimens. Anticancer Res. 2012 Apr; 32(4):1175-80. Suetsugu A, Katz M, Fleming J, Truty M, Thomas R, Saji S, Moriwaki H, Bouvet M, Hoffman RM. PMID: 22493347.
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    687. Major liver resection stimulates stromal recruitment and metastasis compared with repeated minor resection. J Surg Res. 2012 Nov; 178(1):280-7. Momiyama M, Kumamoto T, Suetsugu A, Kishimoto H, Chishima T, Tanaka K, Akiyama H, Ichikawa Y, Bouvet M, Endo I, Hoffman RM. PMID: 22487397; PMCID: PMC3396724.
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    688. Real-time in vivo cellular imaging of graft-versus-host disease and its reaction to immunomodulatory reagents. Immunol Lett. 2012 May 30; 144(1-2):33-40. Yamazaki T, Aoki K, Heike Y, Kim SW, Ochiya T, Wakeda T, Hoffman RM, Takaue Y, Nakagama H, Ikarashi Y. PMID: 22426442.
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    689. Imaging the inhibition by anti-β1 integrin antibody of lung seeding of single osteosarcoma cells in live mice. Int J Cancer. 2012 Nov 01; 131(9):2027-33. Kimura H, Tome Y, Momiyama M, Hayashi K, Tsuchiya H, Bouvet M, Hoffman RM. PMID: 22323248.
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    690. Cellular and subcellular imaging in live mice using fluorescent proteins. Curr Pharm Biotechnol. 2012 Mar; 13(4):537-44. Hoffman RM. PMID: 22214502.
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    691. Inhibition and eradication of human glioma with tumor-targeting Salmonella typhimurium in an orthotopic nude-mouse model. Cell Cycle. 2012 Feb 01; 11(3):628-32. Momiyama M, Zhao M, Kimura H, Tran B, Chishima T, Bouvet M, Endo I, Hoffman RM. PMID: 22274398; PMCID: PMC3315098.
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    692. In vivo imaging of nuclear-cytoplasmic deformation and partition during cancer cell death due to immune rejection. J Cell Biochem. 2012 Feb; 113(2):465-72. Amoh Y, Hamada Y, Katsuoka K, Hoffman RM. PMID: 21938737.
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    693. Lentivirus-based DsRed-2-transfected pancreatic cancer cells for deep in vivo imaging of metastatic disease. Methods Mol Biol. 2012; 872:69-83. Yu Z, Zhou J, Hoffman RM. PMID: 22700404.
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    694. Shedding (killer) light on tumors. Semin Thorac Cardiovasc Surg. 2012; 24(4):235-7. Hoffman RM, Bouvet M. PMID: 23465668.
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    695. Efficacy against lung metastasis with a tumor-targeting mutant of Salmonella typhimurium in immunocompetent mice. Cell Cycle. 2012 Jan 01; 11(1):187-93. Zhao M, Suetsugu A, Ma H, Zhang L, Liu F, Zhang Y, Tran B, Hoffman RM. PMID: 22186786; PMCID: PMC3272237.
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    696. Fluorescence lifetime microscopy of tumor cell invasion, drug delivery, and cytotoxicity. Methods Enzymol. 2012; 504:109-25. Bakker GJ, Andresen V, Hoffman RM, Friedl P. PMID: 22264531.
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    697. Color-coded real-time subcellular fluorescence imaging of the interaction between cancer and host cells in live mice. Anticancer Res. 2012 Jan; 32(1):39-43. Yamauchi K, Tome Y, Yamamoto N, Hayashi K, Kimura H, Tsuchiya H, Tomita K, Bouvet M, Hoffman RM. PMID: 22213286.
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    698. In vivo imaging of pancreatic cancer with fluorescent proteins in mouse models. Methods Mol Biol. 2012; 872:51-67. Bouvet M, Hoffman RM. PMID: 22700403.
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    699. The cyan fluorescent protein nude mouse as a host for multicolor-coded imaging models of primary and metastatic tumor microenvironments. Anticancer Res. 2012 Jan; 32(1):31-8. Suetsugu A, Hassanein MK, Reynoso J, Osawa Y, Nagaki M, Moriwaki H, Saji S, Bouvet M, Hoffman RM. PMID: 22213285.
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    700. Subcellular imaging in vivo: the next GFP revolution. Methods Mol Biol. 2012; 872:255-63. Hoffman RM. PMID: 22700417.
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    701. Live cell imaging in live animals with fluorescent proteins. Methods Enzymol. 2012; 506:197-224. Hoffman RM. PMID: 22341226.
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    702. The preclinical discovery of bacterial therapy for the treatment of metastatic cancer with unique advantages. Expert Opin Drug Discov. 2012 Jan; 7(1):73-83. Hoffman RM. PMID: 22468895.
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    703. Stem-like and non-stem human pancreatic cancer cells distinguished by morphology and metastatic behavior. J Cell Biochem. 2011 Dec; 112(12):3549-54. Hassanein MK, Suetsugu A, Saji S, Moriwaki H, Bouvet M, Moossa AR, Hoffman RM. PMID: 21780159.
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    704. Lectin-immobilized fluorescent nanospheres for targeting to colorectal cancer from a physicochemical perspective. Curr Drug Discov Technol. 2011 Dec 01; 8(4):367-78. Sakuma S, Yamashita S, Hiwatari K, Hoffman RM, Pham W. PMID: 21644921.
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    705. Glowing tumors make for better detection and resection. Sci Transl Med. 2011 Nov 23; 3(110):110fs10. Bouvet M, Hoffman RM. PMID: 22116932.
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    706. Nestin-positive hair follicle pluripotent stem cells can promote regeneration of impinged peripheral nerve injury. J Dermatol. 2012 Jan; 39(1):33-8. Amoh Y, Aki R, Hamada Y, Niiyama S, Eshima K, Kawahara K, Sato Y, Tani Y, Hoffman RM, Katsuoka K. PMID: 22098554.
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    707. Tail spontaneous metastatic mouse model: comparison of metastatic potential of orthotopic and heterotopic models imaged by GFP and RFP protein. In Vivo. 2011 Nov-Dec; 25(6):849-52. Bobek V, Kolostova K, Pinterova D, Boubelik M, Gurlich R, Hoffman RM. PMID: 22021676.
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    708. Comparison of cancer-cell seeding, viability and deformation in the lung, muscle and liver, visualized by subcellular real-time imaging in the live mouse. Anticancer Res. 2011 Nov; 31(11):3665-72. Hayashi K, Kimura H, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Kishimoto H, Hasegawa A, Bouvet M, Hoffman RM. PMID: 22110185.
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    709. HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers. Cancer Res. 2011 Nov 01; 71(21):6633-42. Murata T, Mizushima H, Chinen I, Moribe H, Yagi S, Hoffman RM, Kimura T, Yoshino K, Ueda Y, Enomoto T, Mekada E. PMID: 22009535.
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    710. A rapid imageable in vivo metastasis assay for circulating tumor cells. Anticancer Res. 2011 Oct; 31(10):3125-8. Menen RS, Pinney E, Kolostova K, Bobek V, Suetsugu A, Zhang N, Bouvet M, Hoffman RM. PMID: 21965717.
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    711. Comparison of μCT, MRI and optical reflectance imaging for assessing the growth of GFP/RFP-expressing tumors. Anticancer Res. 2011 Sep; 31(9):2907-13. Abou-Elkacem L, Gremse F, Barth S, Hoffman RM, Kiessling F, Lederle W. PMID: 21868537.
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    712. Development of new spontaneous metastatic heterotopic model of lewis lung carcinoma imaged by GFP expression. Cancer Invest. 2011 Dec; 29(10):692-5. Bobek V, Kolostova K, Pinterova D, Boubelik M, Hoffman RM. PMID: 21877939.
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    713. Tumor-selective, adenoviral-mediated GFP genetic labeling of human cancer in the live mouse reports future recurrence after resection. Cell Cycle. 2011 Aug 15; 10(16):2737-41. Kishimoto H, Aki R, Urata Y, Bouvet M, Momiyama M, Tanaka N, Fujiwara T, Hoffman RM. PMID: 21785265; PMCID: PMC3219541.
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    714. The bulge area is the origin of nestin-expressing pluripotent stem cells of the hair follicle. J Cell Biochem. 2011 Aug; 112(8):2046-50. Uchugonova A, Duong J, Zhang N, König K, Hoffman RM. PMID: 21465525.
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    715. Imaging of the interaction of cancer cells and the lymphatic system. Adv Drug Deliv Rev. 2011 Sep 10; 63(10-11):886-9. Tran Cao HS, McElroy M, Kaushal S, Hoffman RM, Bouvet M. PMID: 21718727; PMCID: PMC3164753.
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    716. Submillimeter-resolution fluorescence laparoscopy of pancreatic cancer in a carcinomatosis mouse model visualizes metastases not seen with standard laparoscopy. J Laparoendosc Adv Surg Tech A. 2011 Jul-Aug; 21(6):485-9. Tran Cao HS, Kaushal S, Menen RS, Metildi CA, Lee C, Snyder CS, Talamini MA, Hoffman RM, Bouvet M. PMID: 21699431; PMCID: PMC3142857.
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    717. Watching stem cells in the skin of living mice noninvasively. Cell Cycle. 2011 Jun 15; 10(12):2017-20. Uchugonova A, Hoffman RM, Weinigel M, Koenig K. PMID: 21558804.
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    718. Time-course imaging of therapeutic functional tumor vascular normalization by antiangiogenic agents. Mol Cancer Ther. 2011 Jul; 10(7):1173-84. Zhang Q, Bindokas V, Shen J, Fan H, Hoffman RM, Xing HR. PMID: 21586628.
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    719. Circulating human prostate cancer cells from an orthotopic mouse model rapidly captured by immunomagnetic beads and imaged by GFP expression. Anticancer Res. 2011 May; 31(5):1535-9. Kolostova K, Pinterova D, Hoffman RM, Bobek V. PMID: 21617207.
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    720. Tumor-seeking Salmonella amino acid auxotrophs. Curr Opin Biotechnol. 2011 Dec; 22(6):917-23. Hoffman RM. PMID: 21498066.
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    721. Knockdown of the β(1) integrin subunit reduces primary tumor growth and inhibits pancreatic cancer metastasis. Int J Cancer. 2011 Dec 15; 129(12):2905-15. Grzesiak JJ, Tran Cao HS, Burton DW, Kaushal S, Vargas F, Clopton P, Snyder CS, Deftos LJ, Hoffman RM, Bouvet M. PMID: 21491421; PMCID: PMC3167925.
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    722. Characterization of nerve conduits seeded with neurons and Schwann cells derived from hair follicle neural crest stem cells. Tissue Eng Part A. 2011 Jul; 17(13-14):1691-8. Lin H, Liu F, Zhang C, Zhang Z, Kong Z, Zhang X, Hoffman RM. PMID: 21338335.
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    723. Imaging the recruitment of cancer-associated fibroblasts by liver-metastatic colon cancer. J Cell Biochem. 2011 Mar; 112(3):949-53. Suetsugu A, Osawa Y, Nagaki M, Saji S, Moriwaki H, Bouvet M, Hoffman RM. PMID: 21328469.
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    724. The bulge area is the major hair follicle source of nestin-expressing pluripotent stem cells which can repair the spinal cord compared to the dermal papilla. Cell Cycle. 2011 Mar 01; 10(5):830-9. Liu F, Uchugonova A, Kimura H, Zhang C, Zhao M, Zhang L, Koenig K, Duong J, Aki R, Saito N, Mii S, Amoh Y, Katsuoka K, Hoffman RM. PMID: 21330787.
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    725. Tumor imaging with multicolor fluorescent protein expression. Int J Clin Oncol. 2011 Apr; 16(2):84-91. Yamamoto N, Tsuchiya H, Hoffman RM. PMID: 21347627.
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    726. Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling. Nature. 2011 Feb 24; 470(7335):548-53. Tan W, Zhang W, Strasner A, Grivennikov S, Cheng JQ, Hoffman RM, Karin M. PMID: 21326202; PMCID: PMC3166217.
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    727. Magnetic resonance and fluorescence-protein imaging of the anti-angiogenic and anti-tumor efficacy of selenium in an orthotopic model of human colon cancer. Anticancer Res. 2011 Feb; 31(2):387-93. Bhattacharya A, Turowski SG, San Martin ID, Rajput A, Rustum YM, Hoffman RM, Seshadri M. PMID: 21378316; PMCID: PMC3129004.
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    728. Transdifferentiation of glioblastoma cells into vascular endothelial cells. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4274-80. Soda Y, Marumoto T, Friedmann-Morvinski D, Soda M, Liu F, Michiue H, Pastorino S, Yang M, Hoffman RM, Kesari S, Verma IM. PMID: 21262804; PMCID: PMC3060261.
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    729. Selective advantage of resistant strains at trace levels of antibiotics: a simple and ultrasensitive color test for detection of antibiotics and genotoxic agents. Antimicrob Agents Chemother. 2011 Mar; 55(3):1204-10. Liu A, Fong A, Becket E, Yuan J, Tamae C, Medrano L, Maiz M, Wahba C, Lee C, Lee K, Tran KP, Yang H, Hoffman RM, Salih A, Miller JH. PMID: 21199928; PMCID: PMC3067110.
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    730. Nestin-driven green fluorescent protein as an imaging marker for nascent blood vessels in mouse models of cancer. Methods Mol Biol. 2011; 689:183-204. Hoffman RM. PMID: 21153793.
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    731. A clinically relevant, syngeneic model of spontaneous, highly metastatic B16 mouse melanoma. Anticancer Res. 2010 Dec; 30(12):4799-803. Bobek V, Kolostova K, Pinterova D, Kacprzak G, Adamiak J, Kolodziej J, Boubelik M, Kubecova M, Hoffman RM. PMID: 21187455.
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    732. Vessel destruction by tumor-targeting Salmonella typhimurium A1-R is enhanced by high tumor vascularity. Cell Cycle. 2010 Nov 15; 9(22):4518-24. Liu F, Zhang L, Hoffman RM, Zhao M. PMID: 21135579; PMCID: PMC3048048.
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    733. Long-working-distance fluorescence microscope with high-numerical-aperture objectives for variable-magnification imaging in live mice from macro- to subcellular. J Biomed Opt. 2010 Nov-Dec; 15(6):066029. Kimura H, Momiyama M, Tomita K, Tsuchiya H, Hoffman RM. PMID: 21198203.
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    734. Real-time imaging of tumor progression in a fluorescent orthotopic mouse model of thyroid cancer. Anticancer Res. 2010 Nov; 30(11):4415-22. Tran Cao HS, Kaushal S, Snyder CS, Ongkeko WM, Hoffman RM, Bouvet M. PMID: 21115887; PMCID: PMC4453926.
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    735. Simultaneous color-coded imaging to distinguish cancer "stem-like" and non-stem cells in the same tumor. J Cell Biochem. 2010 Nov 01; 111(4):1035-41. Suetsugu A, Osawa Y, Nagaki M, Moriwaki H, Saji S, Bouvet M, Hoffman RM. PMID: 20672309.
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    736. Enhancing magnetic resonance imaging tumor detection with fluorescence intensity and lifetime imaging. J Biomed Opt. 2010 Nov-Dec; 15(6):066012. Erten A, Hall D, Hoh C, Tran Cao HS, Kaushal S, Esener S, Hoffman RM, Bouvet M, Chen J, Kesari S, Makale M. PMID: 21198186; PMCID: PMC3014225.
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    737. The advantages of hair follicle pluripotent stem cells over embryonic stem cells and induced pluripotent stem cells for regenerative medicine. J Dermatol Sci. 2010 Dec; 60(3):131-7. Amoh Y, Katsuoka K, Hoffman RM. PMID: 21036545.
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    738. GFP-fluorescence-guided UVC irradiation inhibits melanoma growth and angiogenesis in nude mice. Anticancer Res. 2010 Sep; 30(9):3291-4. Tsai MH, Aki R, Amoh Y, Hoffman RM, Katsuoka K, Kimura H, Lee C, Chang CH. PMID: 20944099.
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    739. Orthotopic mouse models expressing fluorescent proteins for cancer drug discovery. Expert Opin Drug Discov. 2010 Sep; 5(9):851-66. Hoffman RM. PMID: 22823260.
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    740. UV light killing efficacy of fluorescent protein-expressing cancer cells in vitro and in vivo. J Cell Biochem. 2010 Aug 15; 110(6):1439-46. Kimura H, Lee C, Hayashi K, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Bouvet M, Hoffman RM. PMID: 20506255.
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    741. Embryonic development of hair follicle pluripotent stem (hfPS) cells. Med Mol Morphol. 2010 Jun; 43(2):123-7. Amoh Y, Li L, Katsuoka K, Hoffman RM. PMID: 20683701.
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    742. Metronomic gemcitabine in combination with sunitinib inhibits multisite metastasis and increases survival in an orthotopic model of pancreatic cancer. Mol Cancer Ther. 2010 Jul; 9(7):2068-78. Tran Cao HS, Bouvet M, Kaushal S, Keleman A, Romney E, Kim G, Fruehauf J, Imagawa DK, Hoffman RM, Katz MH. PMID: 20606044; PMCID: PMC4383085.
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    743. Effective therapeutic targeting of the overexpressed HER-2 receptor in a highly metastatic orthotopic model of esophageal carcinoma. Mol Cancer Ther. 2010 Jul; 9(7):2037-45. Gros SJ, Kurschat N, Dohrmann T, Reichelt U, Dancau AM, Peldschus K, Adam G, Hoffman RM, Izbicki JR, Kaifi JT. PMID: 20606043.
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    744. Magnetic resonance and fluorescence imaging of doxorubicin-loaded nanoparticles using a novel in vivo model. Nanomedicine. 2010 Dec; 6(6):797-807. Erten A, Wrasidlo W, Scadeng M, Esener S, Hoffman RM, Bouvet M, Makale M. PMID: 20599526; PMCID: PMC2980586.
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    745. Advances in cellular, subcellular, and nanoscale imaging in vitro and in vivo. Cytometry A. 2010 Jul; 77(7):667-76. Wessels JT, Yamauchi K, Hoffman RM, Wouters FS. PMID: 20564541.
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    746. High antimetastatic efficacy of MEN4901/T-0128, a novel camptothecin carboxymethyldextran conjugate. J Surg Res. 2011 Dec; 171(2):684-90. Ma H, Li X, Yang Z, Okuno S, Kawaguchi T, Yagi S, Bouvet M, Hoffman RM. PMID: 20851421; PMCID: PMC3008337.
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    747. Fluorescence laparoscopy imaging of pancreatic tumor progression in an orthotopic mouse model. Surg Endosc. 2011 Jan; 25(1):48-54. Tran Cao HS, Kaushal S, Lee C, Snyder CS, Thompson KJ, Horgan S, Talamini MA, Hoffman RM, Bouvet M. PMID: 20533064; PMCID: PMC3003784.
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    748. Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected]. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):10920-5. Wang Y, Kelber JA, Tran Cao HS, Cantin GT, Lin R, Wang W, Kaushal S, Bristow JM, Edgington TS, Hoffman RM, Bouvet M, Yates JR, Klemke RL. PMID: 20534451; PMCID: PMC2890752.
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    749. Marker expression in circulating cancer cells of pancreatic cancer patients. J Surg Res. 2011 Dec; 171(2):631-6. Zhou J, Hu L, Yu Z, Zheng J, Yang D, Bouvet M, Hoffman RM. PMID: 20869080.
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    750. The role of the intravascular microenvironment in spontaneous metastasis development. Int J Cancer. 2010 Jun 01; 126(11):2534-41. Zhang Q, Yang M, Shen J, Gerhold LM, Hoffman RM, Xing HR. PMID: 19847811.
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    751. Complementary use of fluorescence and magnetic resonance imaging of metastatic esophageal cancer in a novel orthotopic mouse model. Int J Cancer. 2010 Jun 01; 126(11):2671-81. Gros SJ, Dohrmann T, Peldschus K, Schurr PG, Kaifi JT, Kalinina T, Reichelt U, Mann O, Strate TG, Adam G, Hoffman RM, Izbicki JR. PMID: 19847813.
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    752. Mobilization of bone marrow stem cells with StemEnhance improves muscle regeneration in cardiotoxin-induced muscle injury. Cell Cycle. 2010 May; 9(9):1819-23. Drapeau C, Antarr D, Ma H, Yang Z, Tang L, Hoffman RM, Schaeffer DJ. PMID: 20404540.
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    753. Direct transplantation of uncultured hair-follicle pluripotent stem (hfPS) cells promotes the recovery of peripheral nerve injury. J Cell Biochem. 2010 May; 110(1):272-7. Amoh Y, Hamada Y, Aki R, Kawahara K, Hoffman RM, Katsuoka K. PMID: 20411592.
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    754. Nestin-expressing interfollicular blood vessel network contributes to skin transplant survival and wound healing. J Cell Biochem. 2010 May; 110(1):80-6. Aki R, Amoh Y, Li L, Katsuoka K, Hoffman RM. PMID: 20225276.
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    755. Broad selective efficacy of recombinant methioninase and polyethylene glycol-modified recombinant methioninase on cancer cells In Vitro. Anticancer Res. 2010 Apr; 30(4):1041-6. Tan Y, Xu M, Hoffman RM. PMID: 20530407.
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    756. Human breast cancer cell lines co-express neuronal, epithelial, and melanocytic differentiation markers in vitro and in vivo. PLoS One. 2010 Mar 16; 5(3):e9712. Zhang Q, Fan H, Shen J, Hoffman RM, Xing HR. PMID: 20300523; PMCID: PMC2838789.
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    757. High-throughput screening for salmonella avirulent mutants that retain targeting of solid tumors. Cancer Res. 2010 Mar 15; 70(6):2165-70. Arrach N, Cheng P, Zhao M, Santiviago CA, Hoffman RM, McClelland M. PMID: 20231149; PMCID: PMC4103738.
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    758. Broad selective efficacy of rMETase and PEG-rMETase on cancer cells in vitro. Anticancer Res. 2010 Mar; 30(3):793-8. Tan Y, Xu M, Hoffman RM. PMID: 20392998.
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    759. Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. J Clin Invest. 2010 Mar; 120(3):694-705. Kioi M, Vogel H, Schultz G, Hoffman RM, Harsh GR, Brown JM. PMID: 20179352; PMCID: PMC2827954.
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    760. Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4299-304. Murphy EA, Shields DJ, Stoletov K, Dneprovskaia E, McElroy M, Greenberg JI, Lindquist J, Acevedo LM, Anand S, Majeti BK, Tsigelny I, Saldanha A, Walsh B, Hoffman RM, Bouvet M, Klemke RL, Vogt PK, Arnold L, Wrasidlo W, Cheresh DA. PMID: 20154271; PMCID: PMC2840076.
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    761. Selective induction of apoptosis in the hamster flank sebaceous gland organ by a topical liposome 5-alpha-reductase inhibitor: a treatment strategy for acne. J Dermatol. 2010 Feb; 37(2):156-62. Li L, Tang L, Baranov E, Yang M, Amoh Y, Katsuoka K, Hoffman RM. PMID: 20175850.
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    762. The combination of 5-FU, leucovorin and CPT-11 (FOLFIRI) prolongs survival through inhibition of metastasis in an orthotopic model of colon cancer. Anticancer Res. 2010 Feb; 30(2):403-8. Ishihara Y, Matsunaga K, Iijima H, Hasegawa G, Suzuki T, Sato A, Kobayashi T, Yang M, Hoffman RM. PMID: 20332446.
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    763. Silencing of RON receptor signaling promotes apoptosis and gemcitabine sensitivity in pancreatic cancers. Cancer Res. 2010 Feb 01; 70(3):1130-40. Logan-Collins J, Thomas RM, Yu P, Jaquish D, Mose E, French R, Stuart W, McClaine R, Aronow B, Hoffman RM, Waltz SE, Lowy AM. PMID: 20103639; PMCID: PMC2943733.
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    764. Color-coded real-time cellular imaging of lung T-lymphocyte accumulation and focus formation in a mouse asthma model. J Allergy Clin Immunol. 2010 Feb; 125(2):461-468.e6. Hasegawa A, Hayashi K, Kishimoto H, Yang M, Tofukuji S, Suzuki K, Nakajima H, Hoffman RM, Shirai M, Nakayama T. PMID: 20031194.
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    765. Detection of early colorectal cancer imaged with peanut agglutinin-immobilized fluorescent nanospheres having surface poly(N-vinylacetamide) chains. Eur J Pharm Biopharm. 2010 Mar; 74(3):451-60. Sakuma S, Yano T, Masaoka Y, Kataoka M, Hiwatari K, Tachikawa H, Shoji Y, Kimura R, Ma H, Yang Z, Tang L, Hoffman RM, Yamashita S. PMID: 20060903.
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    766. Isolation and culture of hair follicle pluripotent stem (hfPS) cells and their use for nerve and spinal cord regeneration. Methods Mol Biol. 2010; 585:401-20. Amoh Y, Hoffman RM. PMID: 19908019.
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    767. Real-time imaging of single cancer-cell dynamics of lung metastasis. J Cell Biochem. 2010 Jan 01; 109(1):58-64. Kimura H, Hayashi K, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Kishimoto H, Bouvet M, Hoffman RM. PMID: 19911396.
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    768. Selective metastatic tumor labeling with green fluorescent protein and killing by systemic administration of telomerase-dependent adenoviruses. Mol Cancer Ther. 2009 Nov; 8(11):3001-8. Kishimoto H, Urata Y, Tanaka N, Fujiwara T, Hoffman RM. PMID: 19887549; PMCID: PMC5529117.
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    769. Low-dose metronomic cyclophosphamide combined with vascular disrupting therapy induces potent antitumor activity in preclinical human tumor xenograft models. Mol Cancer Ther. 2009 Oct; 8(10):2872-81. Daenen LG, Shaked Y, Man S, Xu P, Voest EE, Hoffman RM, Chaplin DJ, Kerbel RS. PMID: 19825805; PMCID: PMC2782518.
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    770. In vivo gene transfer between interacting human osteosarcoma cell lines is associated with acquisition of enhanced metastatic potential. J Cell Biochem. 2009 Oct 01; 108(2):362-7. Tome Y, Tsuchiya H, Hayashi K, Yamauchi K, Sugimoto N, Kanaya F, Tomita K, Hoffman RM. PMID: 19623575.
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    771. Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal-derived factor 1. Cancer Res. 2009 Sep 15; 69(18):7243-51. Folkins C, Shaked Y, Man S, Tang T, Lee CR, Zhu Z, Hoffman RM, Kerbel RS. PMID: 19738068; PMCID: PMC3409689.
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    772. CXC-chemokine/CXCR2 biological axis promotes angiogenesis in vitro and in vivo in pancreatic cancer. Int J Cancer. 2009 Sep 01; 125(5):1027-37. Matsuo Y, Raimondo M, Woodward TA, Wallace MB, Gill KR, Tong Z, Burdick MD, Yang Z, Strieter RM, Hoffman RM, Guha S. PMID: 19431209.
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    773. In vivo internal tumor illumination by telomerase-dependent adenoviral GFP for precise surgical navigation. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14514-7. Kishimoto H, Zhao M, Hayashi K, Urata Y, Tanaka N, Fujiwara T, Penman S, Hoffman RM. PMID: 19706537; PMCID: PMC2732810.
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    774. Human hair follicle pluripotent stem (hfPS) cells promote regeneration of peripheral-nerve injury: an advantageous alternative to ES and iPS cells. J Cell Biochem. 2009 Aug 01; 107(5):1016-20. Amoh Y, Kanoh M, Niiyama S, Hamada Y, Kawahara K, Sato Y, Hoffman RM, Katsuoka K. PMID: 19507228.
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    775. Upregulation of thrombospondin-1 and angiogenesis in an aggressive human pancreatic cancer cell line selected for high metastasis. Mol Cancer Ther. 2009 Jul; 8(7):1779-86. McElroy MK, Kaushal S, Tran Cao HS, Moossa AR, Talamini MA, Hoffman RM, Bouvet M. PMID: 19584238; PMCID: PMC3487474.
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    776. Efficacy of dietary antioxidants combined with a chemotherapeutic agent on human colon cancer progression in a fluorescent orthotopic mouse model. Anticancer Res. 2009 Jul; 29(7):2421-6. Ma H, Das T, Pereira S, Yang Z, Zhao M, Mukerji P, Hoffman RM. PMID: 19596909.
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    777. Efficacy of a genetically-modified Salmonella typhimurium in an orthotopic human pancreatic cancer in nude mice. Anticancer Res. 2009 Jun; 29(6):1873-8. Nagakura C, Hayashi K, Zhao M, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Bouvet M, Hoffman RM. PMID: 19528442.
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    778. Development of the transgenic cyan fluorescent protein (CFP)-expressing nude mouse for "Technicolor" cancer imaging. J Cell Biochem. 2009 May 15; 107(2):328-34. Tran Cao HS, Reynoso J, Yang M, Kimura H, Kaushal S, Snyder CS, Hoffman RM, Bouvet M. PMID: 19306297; PMCID: PMC2833326.
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    779. Cancer metastasis directly eradicated by targeted therapy with a modified Salmonella typhimurium. J Cell Biochem. 2009 Apr 15; 106(6):992-8. Hayashi K, Zhao M, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Hoffman RM. PMID: 19199339; PMCID: PMC2779055.
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    780. Complementarity of ultrasound and fluorescence imaging in an orthotopic mouse model of pancreatic cancer. BMC Cancer. 2009 Apr 08; 9:106. Snyder CS, Kaushal S, Kono Y, Tran Cao HS, Hoffman RM, Bouvet M. PMID: 19351417; PMCID: PMC2679761.
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    781. Monotherapy with a tumor-targeting mutant of S. typhimurium inhibits liver metastasis in a mouse model of pancreatic cancer. J Surg Res. 2010 Dec; 164(2):248-55. Yam C, Zhao M, Hayashi K, Ma H, Kishimoto H, McElroy M, Bouvet M, Hoffman RM. PMID: 19766244; PMCID: PMC2888721.
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    782. Infrared multiphoton microscopy: subcellular-resolved deep tissue imaging. Curr Opin Biotechnol. 2009 Feb; 20(1):54-62. Andresen V, Alexander S, Heupel WM, Hirschberg M, Hoffman RM, Friedl P. PMID: 19324541.
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    783. Tumor-targeting amino acid auxotrophic Salmonella typhimurium. Amino Acids. 2009 Sep; 37(3):509-21. Hoffman RM. PMID: 19291366.
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    784. Systemic targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma in nude mice with a tumor-selective strain of Salmonella typhimurium. Cell Cycle. 2009 Mar 15; 8(6):870-5. Hayashi K, Zhao M, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Kishimoto H, Bouvet M, Hoffman RM. PMID: 19221501.
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    785. The cyan fluorescent protein (CFP) transgenic mouse as a model for imaging pancreatic exocrine cells. JOP. 2009 Mar 09; 10(2):152-6. Tran Cao HS, Kimura H, Kaushal S, Snyder CS, Reynoso J, Hoffman RM, Bouvet M. PMID: 19287108; PMCID: PMC4454444.
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    786. Extended-working-distance multiphoton micromanipulation microscope for deep-penetration imaging in live mice and tissue. J Biomed Opt. 2009 Mar-Apr; 14(2):024032. Makale M, McElroy M, O'Brien P, Hoffman RM, Guo S, Bouvet M, Barnes L, Ingulli E, Cheresh D. PMID: 19405761; PMCID: PMC3098575.
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    787. A transgenic red fluorescent protein-expressing nude mouse for color-coded imaging of the tumor microenvironment. J Cell Biochem. 2009 Feb 01; 106(2):279-84. Yang M, Reynoso J, Bouvet M, Hoffman RM. PMID: 19097136; PMCID: PMC2739131.
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    788. Comment re: Preclinical model of spontaneous melanoma metastasis. Cancer Res. 2009 Jan 15; 69(2):719; author reply 720. Hoffman RM. PMID: 19147591.
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    789. Multipotent nestin-expressing hair follicle stem cells. J Dermatol. 2009 Jan; 36(1):1-9. Amoh Y, Li L, Katsuoka K, Hoffman RM. PMID: 19207430.
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    790. The stem cell mobilizer StemEnhance does not promote tumor growth in an orthotopic model of human breast cancer. Anticancer Res. 2009 Jan; 29(1):443-7. Drapeau C, Ma H, Yang Z, Tang L, Hoffman RM, Schaeffer DJ. PMID: 19331184.
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    791. Effect of verapamil on the expression of EGFR and NM23 in A549 human lung cancer cells. Anticancer Res. 2009 Jan; 29(1):27-32. Zhang C, Lv F, Zhou L, Li X, Wu XX, Hoffman RM. PMID: 19331130.
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    792. Human and mouse hair follicles contain both multipotent and monopotent stem cells. Cell Cycle. 2009 Jan 01; 8(1):176-7. Amoh Y, Kanoh M, Niiyama S, Kawahara K, Sato Y, Katsuoka K, Hoffman RM. PMID: 19106614.
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    793. Dual-color imaging of tumor angiogenesis. Methods Mol Biol. 2009; 515:45-61. Hoffman RM. PMID: 19378118.
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    794. In vitro/in vivo biorecognition of lectin-immobilized fluorescent nanospheres for human colorectal cancer cells. J Control Release. 2009 Feb 20; 134(1):2-10. Sakuma S, Yano T, Masaoka Y, Kataoka M, Hiwatari K, Tachikawa H, Shoji Y, Kimura R, Ma H, Yang Z, Tang L, Hoffman RM, Yamashita S. PMID: 19014984.
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    795. Real-time in vivo green fluorescent protein imaging of a murine leishmaniasis model as a new tool for Leishmania vaccine and drug discovery. Clin Vaccine Immunol. 2008 Dec; 15(12):1764-70. Mehta SR, Huang R, Yang M, Zhang XQ, Kolli B, Chang KP, Hoffman RM, Goto Y, Badaro R, Schooley RT. PMID: 18945882; PMCID: PMC2593180.
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    796. Lentivirus-based DsRed-2-transfected pancreatic cancer cells for deep in vivo imaging of metastatic disease. J Surg Res. 2009 Nov; 157(1):63-70. Zhou J, Yu Z, Zhao S, Hu L, Zheng J, Yang D, Bouvet M, Hoffman RM. PMID: 19589544.
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    797. Color-coded imaging of splenocyte-pancreatic cancer cell interactions in the tumor microenvironment. Cell Cycle. 2008 Sep 15; 7(18):2916-21. McElroy M, Kaushal S, Bouvet M, Hoffman RM. PMID: 18787410; PMCID: PMC4383086.
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    798. Imaging cancer dynamics in vivo at the tumor and cellular level with fluorescent proteins. Clin Exp Metastasis. 2009; 26(4):345-55. Hoffman RM. PMID: 18787963.
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    799. Human tumor growth in nude mice is associated with decreased plasma cysteine and homocysteine. Anticancer Res. 2008 Sep-Oct; 28(5A):2541-4. Al-Awadi F, Yang M, Tan Y, Han Q, Li S, Hoffman RM. PMID: 19035276.
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    800. In vivo fluorescence of medullary carcinoma of the thyroid: a technology with potential to improve visualization of malignant tissue at surgical resection. Ear Nose Throat J. 2008 Aug; 87(8):E1. Johnson TE, Luiken GA, Quigley MM, Xu M, Hoffman RM. PMID: 18712683.
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    801. Fluorophore-conjugated anti-CEA antibody for the intraoperative imaging of pancreatic and colorectal cancer. J Gastrointest Surg. 2008 Nov; 12(11):1938-50. Kaushal S, McElroy MK, Luiken GA, Talamini MA, Moossa AR, Hoffman RM, Bouvet M. PMID: 18665430; PMCID: PMC4396596.
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    802. In vivo real-time imaging of nuclear-cytoplasmic dynamics of dormancy, proliferation and death of cancer cells. APMIS. 2008 Jul-Aug; 116(7-8):716-29. Hoffman RM. PMID: 18834414.
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    803. Salmonella promoters preferentially activated inside tumors. Cancer Res. 2008 Jun 15; 68(12):4827-32. Arrach N, Zhao M, Porwollik S, Hoffman RM, McClelland M. PMID: 18559530.
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    804. Multipotent hair follicle stem cells promote repair of spinal cord injury and recovery of walking function. Cell Cycle. 2008 Jun 15; 7(12):1865-9. Amoh Y, Li L, Katsuoka K, Hoffman RM. PMID: 18583926.
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    805. Imaging of primary and metastatic pancreatic cancer using a fluorophore-conjugated anti-CA19-9 antibody for surgical navigation. World J Surg. 2008 Jun; 32(6):1057-66. McElroy M, Kaushal S, Luiken GA, Talamini MA, Moossa AR, Hoffman RM, Bouvet M. PMID: 18264829; PMCID: PMC4378829.
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    806. The use of transgenic fluorescent mouse strains, fluorescent protein coding vectors, and innovative imaging techniques in the life sciences. Cytometry A. 2008 Jun; 73(6):490-1. Wessels JT, Hoffman RM, Wouters FS. PMID: 18307256.
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    807. Targeted expression of GFP in the hair follicle using ex vivo viral transduction. J Vis Exp. 2008 Mar 17; (13). Hoffman RM, Li L. PMID: 19066571; PMCID: PMC2586868.
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    808. Imaging In Mice With Fluorescent Proteins: From Macro To Subcellular. Sensors (Basel). 2008 Feb 22; 8(2):1157-1173. Hoffman RM. PMID: 27879758; PMCID: PMC3927509.
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    809. Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs. J Med Chem. 2008 Apr 24; 51(8):2412-20. Duan JX, Jiao H, Kaizerman J, Stanton T, Evans JW, Lan L, Lorente G, Banica M, Jung D, Wang J, Ma H, Li X, Yang Z, Hoffman RM, Ammons WS, Hart CP, Matteucci M. PMID: 18257544.
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    810. Fluorescent LYVE-1 antibody to image dynamically lymphatic trafficking of cancer cells in vivo. J Surg Res. 2009 Jan; 151(1):68-73. McElroy M, Hayashi K, Garmy-Susini B, Kaushal S, Varner JA, Moossa AR, Hoffman RM, Bouvet M. PMID: 18599080; PMCID: PMC2628480.
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    811. Induction of cancer metastasis by cyclophosphamide pretreatment of host mice: an opposite effect of chemotherapy. Cancer Res. 2008 Jan 15; 68(2):516-20. Yamauchi K, Yang M, Hayashi K, Jiang P, Yamamoto N, Tsuchiya H, Tomita K, Moossa AR, Bouvet M, Hoffman RM. PMID: 18199547.
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    812. Enzymatic assay for total plasma Cys. Nat Protoc. 2008; 3(11):1778-81. Han Q, Hoffman RM. PMID: 18948977.
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    813. A highly sensitive single-enzyme homocysteine assay. Nat Protoc. 2008; 3(9):1388-94. Tan Y, Hoffman RM. PMID: 18772865.
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    814. Nonradioactive enzymatic assay for plasma and serum vitamin B(6). Nat Protoc. 2008; 3(12):1815-9. Han Q, Hoffman RM. PMID: 18989259.
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    815. Chapter 2. Color-coded fluorescent mouse models of cancer cell interactions with blood vessels and lymphatics. Methods Enzymol. 2008; 445:27-52. McElroy M, Bouvet M, Hoffman RM. PMID: 19022054.
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    816. Recent advances on in vivo imaging with fluorescent proteins. Methods Cell Biol. 2008; 85:485-95. Hoffman RM. PMID: 18155476.
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    817. Color-coded fluorescent protein imaging of angiogenesis: the AngioMouse models. Curr Pharm Des. 2008; 14(36):3810-9. Amoh Y, Katsuoka K, Hoffman RM. PMID: 19128234.
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    818. A better fluorescent protein for whole-body imaging. Trends Biotechnol. 2008 Jan; 26(1):1-4. Hoffman RM. PMID: 18037177.
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    819. Characterization of HCT116 human colon cancer cells in an orthotopic model. J Surg Res. 2008 Jun 15; 147(2):276-81. Rajput A, Dominguez San Martin I, Rose R, Beko A, Levea C, Sharratt E, Mazurchuk R, Hoffman RM, Brattain MG, Wang J. PMID: 17961596.
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    820. Real-time imaging of tumor-cell shedding and trafficking in lymphatic channels. Cancer Res. 2007 Sep 01; 67(17):8223-8. Hayashi K, Jiang P, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Moossa AR, Bouvet M, Hoffman RM. PMID: 17804736.
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    821. Imaging of nucleolar dynamics during the cell cycle of cancer cells in live mice. Cell Cycle. 2007 Nov 01; 6(21):2706-8. Yamauchi K, Yang M, Hayashi K, Jiang P, Yamamoto N, Tsuchiya H, Tomita K, Moossa AR, Bouvet M, Hoffman RM. PMID: 17912040.
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    822. A novel alkylating agent, glufosfamide, enhances the activity of gemcitabine in vitro and in vivo. Neoplasia. 2007 Aug; 9(8):625-33. Ammons WS, Wang JW, Yang Z, Tidmarsh GF, Hoffman RM. PMID: 17786181; PMCID: PMC1950432.
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    823. An imageable metastatic treatment model of nasopharyngeal carcinoma. Clin Cancer Res. 2007 Jul 01; 13(13):3960-7. Liu T, Ding Y, Xie W, Li Z, Bai X, Li X, Fang W, Ren C, Wang S, Hoffman RM, Yao K. PMID: 17606730.
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    824. Mutant PIK3CA-bearing colon cancer cells display increased metastasis in an orthotopic model. Cancer Res. 2007 Jun 15; 67(12):5851-8. Guo XN, Rajput A, Rose R, Hauser J, Beko A, Kuropatwinski K, LeVea C, Hoffman RM, Brattain MG, Wang J. PMID: 17575153.
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    825. Monotherapy with a tumor-targeting mutant of Salmonella typhimurium cures orthotopic metastatic mouse models of human prostate cancer. Proc Natl Acad Sci U S A. 2007 Jun 12; 104(24):10170-4. Zhao M, Geller J, Ma H, Yang M, Penman S, Hoffman RM. PMID: 17548809; PMCID: PMC1891231.
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    826. Whole-body subcellular multicolor imaging of tumor-host interaction and drug response in real time. Cancer Res. 2007 Jun 01; 67(11):5195-200. Yang M, Jiang P, Hoffman RM. PMID: 17545599.
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    827. Dual-color imaging of angiogenesis and its inhibition in bone and soft tissue sarcoma. J Surg Res. 2007 Jun 15; 140(2):165-70. Hayashi K, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Amoh Y, Hoffman RM, Bouvet M. PMID: 17418866; PMCID: PMC1994962.
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    828. Noninvasive imaging for evaluation of the systemic delivery of capsid-modified adenovirus in an orthotopic model of advanced lung cancer. Cancer. 2007 Mar 15; 109(6):1213; author reply 1214. Hoffman RM. PMID: 17279581.
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    829. The potential of nestin-expressing hair follicle stem cells in regenerative medicine. Expert Opin Biol Ther. 2007 Mar; 7(3):289-91. Hoffman RM. PMID: 17309321.
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    831. The camptothecin derivative CPT-11 inhibits angiogenesis in a dual-color imageable orthotopic metastatic nude mouse model of human colon cancer. Anticancer Res. 2007 Mar-Apr; 27(2):713-8. Ji Y, Hayashi K, Amoh Y, Tsuji K, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Bouvet M, Hoffman RM. PMID: 17465193.
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    832. In vitro photodynamic therapy of childhood rhabdomyosarcoma. Int J Oncol. 2007 Mar; 30(3):615-20. Seitz G, Warmann SW, Armeanu S, Heitmann H, Ruck P, Hoffman RM, Fuchs J, Wessels JT. PMID: 17273762.
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    833. Structure of the antitumour enzyme L-methionine gamma-lyase from Pseudomonas putida at 1.8 A resolution. J Biochem. 2007 Apr; 141(4):535-44. Kudou D, Misaki S, Yamashita M, Tamura T, Takakura T, Yoshioka T, Yagi S, Hoffman RM, Takimoto A, Esaki N, Inagaki K. PMID: 17289792.
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    834. Biomimetic amplification of nanoparticle homing to tumors. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):932-6. Simberg D, Duza T, Park JH, Essler M, Pilch J, Zhang L, Derfus AM, Yang M, Hoffman RM, Bhatia S, Sailor MJ, Ruoslahti E. PMID: 17215365; PMCID: PMC1783417.
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    835. Subcellular imaging of cancer cells in live mice. Methods Mol Biol. 2007; 411:121-9. Hoffman RM. PMID: 18287642.
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    836. In vivo color-coded imaging of the interaction of colon cancer cells and splenocytes in the formation of liver metastases. Cancer Res. 2006 Dec 01; 66(23):11293-7. Bouvet M, Tsuji K, Yang M, Jiang P, Moossa AR, Hoffman RM. PMID: 17145875.
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    837. Visualization of nascent tumor angiogenesis in lung and liver metastasis by differential dual-color fluorescence imaging in nestin-linked-GFP mice. Clin Exp Metastasis. 2006; 23(7-8):315-22. Amoh Y, Bouvet M, Li L, Tsuji K, Moossa AR, Katsuoka K, Hoffman RM. PMID: 17136576.
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    838. Targeting the lymphotoxin-beta receptor with agonist antibodies as a potential cancer therapy. Cancer Res. 2006 Oct 01; 66(19):9617-24. Lukashev M, LePage D, Wilson C, Bailly V, Garber E, Lukashin A, Ngam-ek A, Zeng W, Allaire N, Perrin S, Xu X, Szeliga K, Wortham K, Kelly R, Bottiglio C, Ding J, Griffith L, Heaney G, Silverio E, Yang W, Jarpe M, Fawell S, Reff M, Carmillo A, Miatkowski K, Amatucci J, Crowell T, Prentice H, Meier W, Violette SM, Mackay F, Yang D, Hoffman R, Browning JL. PMID: 17018619.
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    839. Real-time subcellular imaging in live animals: new visible targets for cancer drug discovery. IDrugs. 2006 Sep; 9(9):632-5. Hoffman RM. PMID: 16952071.
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    840. Dual-color imaging of nascent angiogenesis and its inhibition in liver metastases of pancreatic cancer. Anticancer Res. 2006 Sep-Oct; 26(5A):3237-42. Amoh Y, Nagakura C, Maitra A, Moossa AR, Katsuoka K, Hoffman RM, Bouvet M. PMID: 17094435.
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    841. Essential role for activation of the Polycomb group (PcG) protein chromatin silencing pathway in metastatic prostate cancer. Cell Cycle. 2006 Aug; 5(16):1886-901. Berezovska OP, Glinskii AB, Yang Z, Li XM, Hoffman RM, Glinsky GV. PMID: 16963837.
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    842. Visualization of xenotransplanted human rhabdomyosarcoma after transfection with red fluorescent protein. J Pediatr Surg. 2006 Aug; 41(8):1369-76. Seitz G, Warmann SW, Fuchs J, Mau-Holzmann UA, Ruck P, Heitmann H, Hoffman RM, Mahrt J, Müller GA, Wessels JT. PMID: 16863839.
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    843. Targeted therapy with a Salmonella typhimurium leucine-arginine auxotroph cures orthotopic human breast tumors in nude mice. Cancer Res. 2006 Aug 01; 66(15):7647-52. Zhao M, Yang M, Ma H, Li X, Tan X, Li S, Yang Z, Hoffman RM. PMID: 16885365.
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    844. Chemotherapy targets the hair-follicle vascular network but not the stem cells. J Invest Dermatol. 2007 Jan; 127(1):11-5. Amoh Y, Li L, Katsuoka K, Hoffman RM. PMID: 16841031.
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    845. Tumor cells genetically labeled with GFP in the nucleus and RFP in the cytoplasm for imaging cellular dynamics. Cell Cycle. 2006 Jun; 5(11):1198-201. Jiang P, Yamauchi K, Yang M, Tsuji K, Xu M, Maitra A, Bouvet M, Hoffman RM. PMID: 16760659.
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    846. The hair follicle and its stem cells as drug delivery targets. Expert Opin Drug Deliv. 2006 May; 3(3):437-43. Hoffman RM. PMID: 16640502.
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    847. Development of real-time subcellular dynamic multicolor imaging of cancer-cell trafficking in live mice with a variable-magnification whole-mouse imaging system. Cancer Res. 2006 Apr 15; 66(8):4208-14. Yamauchi K, Yang M, Jiang P, Xu M, Yamamoto N, Tsuchiya H, Tomita K, Moossa AR, Bouvet M, Hoffman RM. PMID: 16618743.
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    848. The bisphosphonate olpadronate inhibits skeletal prostate cancer progression in a green fluorescent protein nude mouse model. Clin Cancer Res. 2006 Apr 15; 12(8):2602-6. Yang M, Burton DW, Geller J, Hillegonds DJ, Hastings RH, Deftos LJ, Hoffman RM. PMID: 16638872.
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    849. Common bile duct injection as a novel method for establishing red fluorescent protein (RFP)-expressing human pancreatic cancer in nude mice. JOP. 2006 Mar 09; 7(2):193-9. Tsuji K, Yang M, Jiang P, Maitra A, Kaushal S, Yamauchi K, Katz MH, Moossa AR, Hoffman RM, Bouvet M. PMID: 16525203.
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    850. Physicochemical and pharmacokinetic characterization of highly potent recombinant L-methionine gamma-lyase conjugated with polyethylene glycol as an antitumor agent. Cancer Res. 2006 Mar 01; 66(5):2807-14. Takakura T, Takimoto A, Notsu Y, Yoshida H, Ito T, Nagatome H, Ohno M, Kobayashi Y, Yoshioka T, Inagaki K, Yagi S, Hoffman RM, Esaki N. PMID: 16510603.
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    851. Dual-color imaging of nascent blood vessels vascularizing pancreatic cancer in an orthotopic model demonstrates antiangiogenesis efficacy of gemcitabine. J Surg Res. 2006 May 15; 132(2):164-9. Amoh Y, Li L, Tsuji K, Moossa AR, Katsuoka K, Hoffman RM, Bouvet M. PMID: 16500746.
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    852. Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds. Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8):2800-4. Pilch J, Brown DM, Komatsu M, Järvinen TA, Yang M, Peters D, Hoffman RM, Ruoslahti E. PMID: 16476999; PMCID: PMC1413849.
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    853. The pluripotency of hair follicle stem cells. Cell Cycle. 2006 Feb; 5(3):232-3. Hoffman RM. PMID: 16410728.
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    854. Dual-color-coded imaging of viable circulating prostate carcinoma cells reveals genetic exchange between tumor cells in vivo, contributing to highly metastatic phenotypes. Cell Cycle. 2006 Jan; 5(2):191-7. Glinsky GV, Glinskii AB, Berezovskaya O, Smith BA, Jiang P, Li XM, Yang M, Hoffman RM. PMID: 16357534.
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    855. Dual-color imaging of nuclear-cytoplasmic dynamics, viability, and proliferation of cancer cells in the portal vein area. Cancer Res. 2006 Jan 01; 66(1):303-6. Tsuji K, Yamauchi K, Yang M, Jiang P, Bouvet M, Endo H, Kanai Y, Yamashita K, Moossa AR, Hoffman RM. PMID: 16397243.
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    856. Subcellular imaging in the live mouse. Nat Protoc. 2006; 1(2):775-82. Hoffman RM, Yang M. PMID: 17406307.
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    857. Color-coded fluorescence imaging of tumor-host interactions. Nat Protoc. 2006; 1(2):928-35. Hoffman RM, Yang M. PMID: 17406326.
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    858. Whole-body imaging of bacterial infection and antibiotic response. Nat Protoc. 2006; 1(6):2988-94. Hoffman RM, Zhao M. PMID: 17406559.
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    859. Whole-body imaging with fluorescent proteins. Nat Protoc. 2006; 1(3):1429-38. Hoffman RM, Yang M. PMID: 17406431.
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    860. Follicular penetration and targeting. J Investig Dermatol Symp Proc. 2005 Dec; 10(3):301-3. Lademann J, Otberg N, Jacobi U, Hoffman RM, Blume-Peytavi U. PMID: 16382687.
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    861. Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17734-8. Amoh Y, Li L, Campillo R, Kawahara K, Katsuoka K, Penman S, Hoffman RM. PMID: 16314569; PMCID: PMC1308908.
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    862. High correlation of whole-body red fluorescent protein imaging and magnetic resonance imaging on an orthotopic model of pancreatic cancer. Cancer Res. 2005 Nov 01; 65(21):9829-33. Bouvet M, Spernyak J, Katz MH, Mazurchuk RV, Takimoto S, Bernacki R, Rustum YM, Moossa AR, Hoffman RM. PMID: 16267005.
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    863. The multiple uses of fluorescent proteins to visualize cancer in vivo. Nat Rev Cancer. 2005 Oct; 5(10):796-806. Hoffman RM. PMID: 16195751.
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    864. Facile whole-body imaging of internal fluorescent tumors in mice with an LED flashlight. Biotechniques. 2005 Aug; 39(2):170, 172. Yang M, Luiken G, Baranov E, Hoffman RM. PMID: 16116787.
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    865. High-level expression and bulk crystallization of recombinant L-methionine gamma-lyase, an anticancer agent. Appl Microbiol Biotechnol. 2006 Mar; 70(2):183-92. Takakura T, Ito T, Yagi S, Notsu Y, Itakura T, Nakamura T, Inagaki K, Esaki N, Hoffman RM, Takimoto A. PMID: 16012835.
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    866. Advantages of multi-color fluorescent proteins for whole-body and in vivo cellular imaging. J Biomed Opt. 2005 Jul-Aug; 10(4):41202. Hoffman RM. PMID: 16178626.
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    867. Dual-color, whole-body imaging in mice. Nat Biotechnol. 2005 Jul; 23(7):790; author reply 791. Hoffman RM, Yang M. PMID: 16003354.
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    868. Nestin-linked green fluorescent protein transgenic nude mouse for imaging human tumor angiogenesis. Cancer Res. 2005 Jun 15; 65(12):5352-7. Amoh Y, Yang M, Li L, Reynoso J, Bouvet M, Moossa AR, Katsuoka K, Hoffman RM. PMID: 15958583.
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    869. Real-time in vivo dual-color imaging of intracapillary cancer cell and nucleus deformation and migration. Cancer Res. 2005 May 15; 65(10):4246-52. Yamauchi K, Yang M, Jiang P, Yamamoto N, Xu M, Amoh Y, Tsuji K, Bouvet M, Tsuchiya H, Tomita K, Moossa AR, Hoffman RM. PMID: 15899816.
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    870. Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5530-4. Amoh Y, Li L, Katsuoka K, Penman S, Hoffman RM. PMID: 15802470; PMCID: PMC556262.
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    871. Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells. Cancer Res. 2005 Mar 15; 65(6):2378-86. Berezovskaya O, Schimmer AD, Glinskii AB, Pinilla C, Hoffman RM, Reed JC, Glinsky GV. PMID: 15781653.
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    872. Hair follicle-derived blood vessels vascularize tumors in skin and are inhibited by Doxorubicin. Cancer Res. 2005 Mar 15; 65(6):2337-43. Amoh Y, Li L, Yang M, Jiang P, Moossa AR, Katsuoka K, Hoffman RM. PMID: 15781648.
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    873. Real-time whole-body imaging of an orthotopic metastatic prostate cancer model expressing red fluorescent protein. Prostate. 2005 Mar 01; 62(4):374-9. Yang M, Jiang P, Yamamoto N, Li L, Geller J, Moossa AR, Hoffman RM. PMID: 15389802.
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    874. Direct evidence that PTHrP expression promotes prostate cancer progression in bone. Biochem Biophys Res Commun. 2005 Feb 11; 327(2):468-72. Deftos LJ, Barken I, Burton DW, Hoffman RM, Geller J. PMID: 15629138.
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    875. Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):755-60. Zhao M, Yang M, Li XM, Jiang P, Baranov E, Li S, Xu M, Penman S, Hoffman RM. PMID: 15644448; PMCID: PMC545558.
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    876. In vivo cell biology of cancer cells visualized with fluorescent proteins. Curr Top Dev Biol. 2005; 70:121-44. Hoffman RM. PMID: 16338340.
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    877. Orthotopic metastatic (MetaMouse) models for discovery and development of novel chemotherapy. Methods Mol Med. 2005; 111:297-322. Hoffman RM. PMID: 15911987.
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    878. A rapid HPLC method for the measurement of ultra-low plasma methionine concentrations applicable to methionine depletion therapy. Anticancer Res. 2005 Jan-Feb; 25(1A):59-62. Sun X, Tan Y, Yang Z, Li S, Hoffman RM. PMID: 15816519.
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    879. Gene and stem cell therapy of the hair follicle. Methods Mol Biol. 2005; 289:437-48. Hoffman RM. PMID: 15502205.
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    880. Transgenic nude mouse with ubiquitous green fluorescent protein expression as a host for human tumors. Cancer Res. 2004 Dec 01; 64(23):8651-6. Yang M, Reynoso J, Jiang P, Li L, Moossa AR, Hoffman RM. PMID: 15574773.
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    881. Visualizing portal vein metastatic trafficking to the liver with green fluorescent protein-expressing tumor cells. Anticancer Res. 2004 Nov-Dec; 24(6):3699-702. Wang J, Yang M, Hoffman RM. PMID: 15736399.
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    882. Color coding cancer cells with fluorescent proteins to visualize in vivo cellular interaction in metastatic colonies. Anticancer Res. 2004 Nov-Dec; 24(6):4067-72. Yamamoto N, Yang M, Jiang P, Xu M, Yamauchi K, Tsuchiya H, Tomita K, Moossa AR, Hoffman RM. PMID: 15736453.
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    883. PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methioninase in primates. Cancer Res. 2004 Sep 15; 64(18):6673-8. Yang Z, Wang J, Lu Q, Xu J, Kobayashi Y, Takakura T, Takimoto A, Yoshioka T, Lian C, Chen C, Zhang D, Zhang Y, Li S, Sun X, Tan Y, Yagi S, Frenkel EP, Hoffman RM. PMID: 15374983.
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    884. 3-Deazaadenosine, a stabilizer of whole-blood homocysteine content, does not interfere with the single-enzyme homocysteine assay while totally inhibiting the enzyme conversion homocysteine immunoassay. Clin Chem. 2004 Sep; 50(9):1703-4. Han Q, Sun X, Xu M, Zhang N, Tang L, Tan Y, Hoffman RM. PMID: 15331515.
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    885. Nascent blood vessels in the skin arise from nestin-expressing hair-follicle cells. Proc Natl Acad Sci U S A. 2004 Sep 07; 101(36):13291-5. Amoh Y, Li L, Yang M, Moossa AR, Katsuoka K, Penman S, Hoffman RM. PMID: 15331785; PMCID: PMC516562.
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    886. Circulating half-life of PEGylated recombinant methioninase holoenzyme is highly dose dependent on cofactor pyridoxal-5'-phosphate. Cancer Res. 2004 Aug 15; 64(16):5775-8. Yang Z, Sun X, Li S, Tan Y, Wang X, Zhang N, Yagi S, Takakura T, Kobayashi Y, Takimoto A, Yoshioka T, Suginaka A, Frenkel EP, Hoffman RM. PMID: 15313919.
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    887. Protein carboxyl amidation increases the potential extent of protein polyethylene glycol conjugation. Anal Biochem. 2004 Jul 15; 330(2):264-71. Li S, Yang Z, Sun X, Tan Y, Yagi S, Hoffman RM. PMID: 15203332.
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    888. Homogeneous enzymatic colorimetric assay for total cysteine. Clin Chem. 2004 Jul; 50(7):1229-31. Han Q, Xu M, Tang L, Sun X, Zhang N, Tan X, Tan X, Tan Y, Hoffman RM. PMID: 15229150.
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    889. Imaging tumor angiogenesis with fluorescent proteins. APMIS. 2004 Jul-Aug; 112(7-8):441-9. Hoffman RM. PMID: 15563308.
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    890. Cellular dynamics visualized in live cells in vitro and in vivo by differential dual-color nuclear-cytoplasmic fluorescent-protein expression. Cancer Res. 2004 Jun 15; 64(12):4251-6. Yamamoto N, Jiang P, Yang M, Xu M, Yamauchi K, Tsuchiya H, Tomita K, Wahl GM, Moossa AR, Hoffman RM. PMID: 15205338.
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    891. Antitumor activity of a homing peptide that targets tumor lymphatics and tumor cells. Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9381-6. Laakkonen P, Akerman ME, Biliran H, Yang M, Ferrer F, Karpanen T, Hoffman RM, Ruoslahti E. PMID: 15197262; PMCID: PMC438985.
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    892. Oral 5-FU is a more effective antimetastatic agent than UFT. Anticancer Res. 2004 May-Jun; 24(3a):1353-60. Wang J, Yang M, Yagi S, Hoffman RM. PMID: 15274295.
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    893. Pharmacokinetics, methionine depletion, and antigenicity of recombinant methioninase in primates. Clin Cancer Res. 2004 Mar 15; 10(6):2131-8. Yang Z, Wang J, Yoshioka T, Li B, Lu Q, Li S, Sun X, Tan Y, Yagi S, Frenkel EP, Hoffman RM. PMID: 15041734.
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    894. Gene expression profiling predicts clinical outcome of prostate cancer. J Clin Invest. 2004 Mar; 113(6):913-23. Glinsky GV, Glinskii AB, Stephenson AJ, Hoffman RM, Gerald WL. PMID: 15067324; PMCID: PMC362118.
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    895. Survival efficacy of adjuvant cytosine-analogue CS-682 in a fluorescent orthotopic model of human pancreatic cancer. Cancer Res. 2004 Mar 01; 64(5):1828-33. Katz MH, Bouvet M, Takimoto S, Spivack D, Moossa AR, Hoffman RM. PMID: 14996746.
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    896. Development of a green fluorescent protein metastatic-cancer chick-embryo drug-screen model. Clin Exp Metastasis. 2004; 21(4):347-52. Bobek V, Plachy J, Pinterova D, Kolostova K, Boubelik M, Jiang P, Yang M, Hoffman RM. PMID: 15554391.
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    897. In vivo imaging with fluorescent proteins: the new cell biology. Acta Histochem. 2004; 106(2):77-87. Hoffman RM. PMID: 15147628.
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    899. Syngeneic lymph-node-targeting model of green fluorescent protein-expressing Lewis lung carcinoma. Clin Exp Metastasis. 2004; 21(8):705-8. Bobek V, Kolostova K, Pinterov D, Boubelik M, Jiang P, Yang M, Hoffman RM. PMID: 16035615.
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    900. In vivo efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol conjugation and pyridoxal 5'-phosphate supplementation. Cancer Res. 2003 Dec 01; 63(23):8377-83. Sun X, Yang Z, Li S, Tan Y, Zhang N, Wang X, Yagi S, Yoshioka T, Takimoto A, Mitsushima K, Suginaka A, Frenkel EP, Hoffman RM. PMID: 14678999.
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    902. Dual-color fluorescence imaging distinguishes tumor cells from induced host angiogenic vessels and stromal cells. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14259-62. Yang M, Li L, Jiang P, Moossa AR, Penman S, Hoffman RM. PMID: 14614130; PMCID: PMC283579.
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    905. Prolonged dormancy and site-specific growth potential of cancer cells spontaneously disseminated from nonmetastatic breast tumors as revealed by labeling with green fluorescent protein. Clin Cancer Res. 2003 Sep 01; 9(10 Pt 1):3808-14. Goodison S, Kawai K, Hihara J, Jiang P, Yang M, Urquidi V, Hoffman RM, Tarin D. PMID: 14506175.
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    906. Nestin expression in hair follicle sheath progenitor cells. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):9958-61. Li L, Mignone J, Yang M, Matic M, Penman S, Enikolopov G, Hoffman RM. PMID: 12904579; PMCID: PMC187900.
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    907. Gene therapy of pancreatic cancer with green fluorescent protein and tumor necrosis factor-related apoptosis-inducing ligand fusion gene expression driven by a human telomerase reverse transcriptase promoter. Ann Surg Oncol. 2003 Aug; 10(7):762-72. Katz MH, Spivack DE, Takimoto S, Fang B, Burton DW, Moossa AR, Hoffman RM, Bouvet M. PMID: 12900367.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    908. Viable circulating metastatic cells produced in orthotopic but not ectopic prostate cancer models. Cancer Res. 2003 Jul 15; 63(14):4239-43. Glinskii AB, Smith BA, Jiang P, Li XM, Yang M, Hoffman RM, Glinsky GV. PMID: 12874032.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    909. A novel red fluorescent protein orthotopic pancreatic cancer model for the preclinical evaluation of chemotherapeutics. J Surg Res. 2003 Jul; 113(1):151-60. Katz MH, Takimoto S, Spivack D, Moossa AR, Hoffman RM, Bouvet M. PMID: 12943825.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    910. The activity of camptothecin analogues is enhanced in histocultures of human tumors and human tumor xenografts by modulation of extracellular pH. Cancer Chemother Pharmacol. 2003 Sep; 52(3):253-61. Flowers JL, Hoffman RM, Driscoll TA, Wall ME, Wani MC, Manikumar G, Friedman HS, Dewhirst M, Colvin OM, Adams DJ. PMID: 12783198.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    911. Automated enzymatic assay for homocysteine. Clin Chem. 2003 Jun; 49(6 Pt 1):1029-30. Tan Y, Sun X, Tang L, Zhang N, Han Q, Xu M, Tan X, Tan X, Hoffman RM. PMID: 12766025.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    912. High-resolution magnetic resonance imaging of the efficacy of the cytosine analogue 1-[2-C-cyano-2-deoxy-beta-D-arabino-pentofuranosyl]-N(4)-palmitoyl cytosine (CS-682) in a liver-metastasis athymic nude mouse model. Cancer Res. 2003 May 15; 63(10):2477-82. Wu M, Mazurchuk R, Chaudhary ND, Spernyak J, Veith J, Pera P, Greco W, Hoffman RM, Kobayashi T, Bernacki RJ. PMID: 12750269.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    913. Immune reactions in skin and hair follicle gene therapy. Mol Ther. 2003 Mar; 7(3):294-5. Hoffman RM. PMID: 12668124.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    914. A simultaneous colorimetric assay of free and protein-coupled polyethylene glycol. Anal Biochem. 2003 Feb 15; 313(2):335-7. Li S, Yang Z, Sun X, Tan Y, Yagi S, Hoffman RM. PMID: 12605873.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    915. Metastatic orthotopic mouse models of lung cancer. Methods Mol Med. 2003; 74:457-64. Hoffman RM. PMID: 12415714.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    916. Real-time imaging of individual fluorescent-protein color-coded metastatic colonies in vivo. Clin Exp Metastasis. 2003; 20(7):633-8. Yamamoto N, Yang M, Jiang P, Xu M, Tsuchiya H, Tomita K, Moossa AR, Hoffman RM. PMID: 14669794.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    917. PEG-methioninase. Adv Exp Med Biol. 2003; 519:69-79. Hoffman RM. PMID: 12675209.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    918. Efficacy of camptothecin analog DX-8951f (Exatecan Mesylate) on human pancreatic cancer in an orthotopic metastatic model. Cancer Res. 2003 Jan 01; 63(1):80-5. Sun FX, Tohgo A, Bouvet M, Yagi S, Nassirpour R, Moossa AR, Hoffman RM. PMID: 12517781.
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    919. Real-time GFP imaging of spontaneous HT-1080 fibrosarcoma lung metastases. Clin Exp Metastasis. 2003; 20(2):181-5. Yamamoto N, Yang M, Jiang P, Tsuchiya H, Tomita K, Moossa AR, Hoffman RM. PMID: 12705639.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    920. Antimetastatic efficacy of oral 5-FU imaged by green fluorescent protein in real time. Anticancer Res. 2003 Jan-Feb; 23(1A):1-6. Wang JW, Yang M, Wang X, Sun FX, Li XM, Yagi S, Hoffman RM. PMID: 12680187.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    921. High efficiency genetic modification of hair follicles and growing hair shafts. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):13120-4. Saito N, Zhao M, Li L, Baranov E, Yang M, Ohta Y, Katsuoka K, Penman S, Hoffman RM. PMID: 12232045; PMCID: PMC130596.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    922. TIS7 interacts with the mammalian SIN3 histone deacetylase complex in epithelial cells. EMBO J. 2002 Sep 02; 21(17):4621-31. Vietor I, Vadivelu SK, Wick N, Hoffman R, Cotten M, Seiser C, Fialka I, Wunderlich W, Haase A, Korinkova G, Brosch G, Huber LA. PMID: 12198164; PMCID: PMC125408.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    923. Homogeneous, nonradioactive, enzymatic assay for plasma pyridoxal 5-phosphate. Clin Chem. 2002 Sep; 48(9):1560-4. Han Q, Xu M, Tang L, Tan X, Tan X, Tan Y, Hoffman RM. PMID: 12194934.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    924. Green fluorescent protein imaging of tumour growth, metastasis, and angiogenesis in mouse models. Lancet Oncol. 2002 Sep; 3(9):546-56. Hoffman R. PMID: 12217792.
      View in: PubMed   Mentions: 54     Fields:    Translation:Animals
    925. Treatment of cancer cells with methioninase produces DNA hypomethylation and increases DNA synthesis. Cancer Res. 2002 Aug 15; 62(16):4685-9. Machover D, Zittoun J, Saffroy R, Broët P, Giraudier S, Magnaldo T, Goldschmidt E, Debuire B, Orrico M, Tan Y, Mishal Z, Chevallier O, Tonetti C, Jouault H, Ulusakarya A, Tanguy ML, Metzger G, Hoffman RM. PMID: 12183426.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    926. Visualizing superficial human bladder cancer cell growth in vivo by green fluorescent protein expression. Cancer Gene Ther. 2002 Aug; 9(8):681-6. Zhou JH, Rosser CJ, Tanaka M, Yang M, Baranov E, Hoffman RM, Benedict WF. PMID: 12136429.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    927. Bax-induction gene therapy of pancreatic cancer. J Surg Res. 2002 Aug; 106(2):346-51. Pirocanac EC, Nassirpour R, Yang M, Wang J, Nardin SR, Gu J, Fang B, Moossa AR, Hoffman RM, Bouvet M. PMID: 12175991.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    928. Watching real-time metastasis in vivo. Trends Mol Med. 2002 Jul; 8(7):354-5. Hoffman RM. PMID: 12114116.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    929. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell. 2002 May 03; 109(3):335-46. Schmitt CA, Fridman JS, Yang M, Lee S, Baranov E, Hoffman RM, Lowe SW. PMID: 12015983.
      View in: PubMed   Mentions: 419     Fields:    Translation:AnimalsCells
    930. Prediction of survival in patients with head and neck cancer using the histoculture drug response assay. Head Neck. 2002 May; 24(5):437-42. Singh B, Li R, Xu L, Poluri A, Patel S, Shaha AR, Pfister D, Sherman E, Goberdhan A, Hoffman RM, Shah J. PMID: 12001073.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    931. Dissecting p53 tumor suppressor functions in vivo. Cancer Cell. 2002 Apr; 1(3):289-98. Schmitt CA, Fridman JS, Yang M, Baranov E, Hoffman RM, Lowe SW. PMID: 12086865.
      View in: PubMed   Mentions: 188     Fields:    Translation:HumansAnimals
    932. Parathyroid hormone-related protein as a novel tumor marker in pancreatic adenocarcinoma. Pancreas. 2002 Apr; 24(3):284-90. Bouvet M, Nardin SR, Burton DW, Lee NC, Yang M, Wang X, Baranov E, Behling C, Moossa AR, Hoffman RM, Deftos LJ. PMID: 11893937.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    933. Green fluorescent protein imaging of tumor cells in mice. Lab Anim (NY). 2002 Apr; 31(4):34-41. Hoffman RM. PMID: 11927960.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    934. Direct external imaging of nascent cancer, tumor progression, angiogenesis, and metastasis on internal organs in the fluorescent orthotopic model. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3824-9. Yang M, Baranov E, Wang JW, Jiang P, Wang X, Sun FX, Bouvet M, Moossa AR, Penman S, Hoffman RM. PMID: 11891294; PMCID: PMC122608.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    935. Real-time optical imaging of primary tumor growth and multiple metastatic events in a pancreatic cancer orthotopic model. Cancer Res. 2002 Mar 01; 62(5):1534-40. Bouvet M, Wang J, Nardin SR, Nassirpour R, Yang M, Baranov E, Jiang P, Moossa AR, Hoffman RM. PMID: 11888932.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    936. VEGF receptor antisense therapy inhibits angiogenesis and peritoneal dissemination of human gastric cancer in nude mice. Cancer Gene Ther. 2002 Feb; 9(2):197-201. Kamiyama M, Ichikawa Y, Ishikawa T, Chishima T, Hasegawa S, Hamaguchi Y, Nagashima Y, Miyagi Y, Mitsuhashi M, Hyndman D, Hoffman RM, Ohki S, Shimada H. PMID: 11857038.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    937. Evaluation of an enzymatic method to measure total homocysteine in plasma. Thromb Haemost. 2002 Jan; 87(1):172-3. Tripodi A, Chantarangkul V, Tan Y, Hoffman RM, Cattaneo M. PMID: 11848450.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    938. Whole-body fluorescence imaging with green fluorescence protein. Methods Mol Biol. 2002; 183:135-48. Hoffman RM. PMID: 12136749.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    939. Optically imageable metastatic model of human breast cancer. Clin Exp Metastasis. 2002; 19(4):347-50. Li X, Wang J, An Z, Yang M, Baranov E, Jiang P, Sun F, Moossa AR, Hoffman RM. PMID: 12090475.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
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