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Recombinant Methioninase Lowers the Effective Dose of Regorafenib Against Colon-Cancer Cells: A Strategy for Widespread Clinical Use of a Toxic Drug. Cancer Diagn Progn. 2023 Nov-Dec; 3(6):655-659.
Choobin BB, Kubota Y, Han Q, Ardjmand D, Morinaga S, Mizuta K, Bouvet M, Tsunoda T, Hoffman RM. PMID: 37927805; PMCID: PMC10619565.
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Recombinant-methioninase-producing Escherichia coli Instilled in the Microbiome Inhibits Triple-negative Breast Cancer in an Orthotopic Cell-line Mouse Model. Cancer Diagn Progn. 2023 Nov-Dec; 3(6):649-654.
Kubota Y, Han Q, Morinaga S, Mizuta K, Bouvet M, Tsunoda T, Hoffman RM. PMID: 37927811; PMCID: PMC10619576.
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Non-invasive omics analysis delineates molecular changes in water-only fasting and its sex-discriminating features in metabolic syndrome patients. MedComm (2020). 2023 Dec; 4(6):e393.
Jiang Y, Tang Z, Zhu X, Xiao B, Tian H, Lei X, Peng H, Qin J, Zhang Y, Hoffman RM, Hu X, Chen Q, Ji G, Jia L. PMID: 37929015; PMCID: PMC10622739.
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PubMed Mentions:
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Humanized Anti-Carcinoembryonic Antigen Antibodies Brightly Target and Label Gastric Cancer in Orthotopic Mouse Models. J Surg Res. 2023 Oct 13; 293:701-708.
Cox KE, Turner MA, Amirfakhri S, Lwin TM, Hosseini M, Ghosh P, Obonyo M, Murakami T, Hoffman RM, Yazaki PJ, Bouvet M. PMID: 37839102.
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PubMed Mentions: Fields:
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High Clinical Concordance of Drug Resistance in Patient-derived Orthotopic Xenograft (PDOX) Mouse Models: First Step to Validated Precise Individualized Cancer Chemotherapy. Anticancer Res. 2023 Oct; 43(10):4277-4284.
Higuchi T, Yamamoto N, Hayashi K, Miwa S, Igarashi K, Tsuchiya H, Hoffman RM. PMID: 37772554.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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Rapid Reduction of CEA and Stable Metastasis in an NRAS-mutant Rectal-Cancer Patient Treated With FOLFIRI and Bevacizumab Combined With Oral Recombinant Methioninase and a Low-Methionine Diet Upon Metastatic Recurrence After FOLFIRI and Bevacizumab Treatment Alone. In Vivo. 2023 Sep-Oct; 37(5):2134-2138.
Kubota Y, Han Q, Morinaga S, Tsunoda T, Hoffman RM. PMID: 37652473; PMCID: PMC10500498.
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PubMed Mentions: Fields:
Translation:
Humans
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Methionine Restriction Increases Exosome Production and Secretion in Breast Cancer Cells. Cancer Genomics Proteomics. 2023 Sep-Oct; 20(5):412-416.
Inubushi S, Kunihisa T, Mizumoto S, Inoue S, Miki M, Suetsugu A, Tanino H, Hoffman RM. PMID: 37643781; PMCID: PMC10464940.
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PubMed Mentions: Fields:
Translation:
HumansCells
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SLC26A3/NHERF2-IκB/NFκB/p65 feedback loop suppresses tumorigenesis and metastasis in colorectal cancer. Oncogenesis. 2023 Aug 12; 12(1):41.
Lin C, Lin P, Lin H, Yao H, Liu S, He R, Chen H, Teng Z, Hoffman RM, Ye J, Zhu G. PMID: 37573425; PMCID: PMC10423209.
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PubMed Mentions:
1
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PEGylated Fluorescent Anti-carcinoembryonic Antigen Antibody Labels Colorectal Cancer Tumors in Orthotopic Mouse Models. J Surg Res. 2023 11; 291:596-602.
Turner MA, Amirfakhri S, Nishino H, Neel NC, Hosseini M, Cox KE, Lwin TM, Li L, Hong T, Sherman A, Shively JE, Hoffman RM, Yazaki PJ, Bouvet M. PMID: 37540977.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Long-lasting Limb Salvage After Malignant Femoral-Bone Tumor Resection Reconstructed With a Thin-mantle Titanium Stem Fixated With Cement. Anticancer Res. 2023 Aug; 43(8):3507-3511.
Aoki Y, Tome Y, Oshiro H, Mizuta K, Katsuki R, Hoffman RM, Nishida K. PMID: 37500137.
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PubMed Mentions: Fields:
Translation:
Humans
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Positive Circumferential Resection Margin in Rectal Cancer Is a Robust Predictor of Poor Long-term Prognosis With Clinicopathological Bias Between Groups Compensated by Propensity-score Matching Analysis. Anticancer Res. 2023 Aug; 43(8):3623-3630.
Sugimoto K, Takahashi H, Irie T, Kawaguchi M, Kobari A, Amemiya K, Tsuchiya Y, Motegi S, Tsukamoto R, Honjo K, Okazawa YU, Kawai M, Ishiyama S, Takahashi M, Hoffman RM, Sakamoto K. PMID: 37500146.
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PubMed Mentions: Fields:
Translation:
Humans
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Bioinformatics Analysis of Immune Infiltration In Endometrial Carcinoma Tumors and its Relationship With Prognosis. Cancer Diagn Progn. 2023 Jul-Aug; 3(4):416-427.
Lin Y, Liu S, Bian L, Lin C, Lin P, Teng Z, Hoffman RM, Zhu G, Zhang B. PMID: 37405226; PMCID: PMC10316055.
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PubMed Mentions:
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Targeting Autophagy With the Synergistic Combination of Chloroquine and Rapamycin as a Novel Effective Treatment for Well-differentiated Liposarcoma. Cancer Genomics Proteomics. 2023 Jul-Aug; 20(4):317-322.
Masaki N, Aoki Y, Obara K, Kubota Y, Bouvet M, Miyazaki J, Hoffman RM. PMID: 37400145; PMCID: PMC10320558.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Targeting Methionine Addiction of Cancer Cells with Methioninase. Biochemistry (Mosc). 2023 Jul; 88(7):944-952.
Pokrovsky VS, Qoura LA, Demidova EA, Han Q, Hoffman RM. PMID: 37751865.
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PubMed Mentions: Fields:
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Precise and Facile Endotracheal Lung-tumor-implantation Mouse Model Visualized by GFP Expression. In Vivo. 2023 Jul-Aug; 37(4):1477-1481.
Aoki Y, Kobayashi KJ, Varshney N, Kubota Y, Masaki N, Obara K, Wang JD, Tome Y, Bouvet M, Nishida K, Hoffman RM. PMID: 37369517; PMCID: PMC10347943.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Meckel's Diverticulum Carcinoma Is Arrested by Oxaliplatinum and Eradicated by 5-Fluorouracil in a PDX Mouse Model Indicating Candidate First-line Treatment for a Rare Cancer. In Vivo. 2023 Jul-Aug; 37(4):1482-1485.
Masaki N, Yonemura Y, Hozumi C, Obara K, Kubota Y, Aoki Y, Hoffman RM. PMID: 37369464; PMCID: PMC10347928.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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Old-age-induced obesity reversed by a methionine-deficient diet or oral administration of recombinant methioninase-producing Escherichia coli in C57BL/6 mice. Aging (Albany NY). 2023 06 09; 15(11):4642-4648.
Kubota Y, Han Q, Reynoso J, Aoki Y, Masaki N, Obara K, Hamada K, Bouvet M, Tsunoda T, Hoffman RM. PMID: 37301544; PMCID: PMC10292902.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Colon-cancer liver metastasis is effectively targeted by recombinant methioninase (rMETase) in an orthotopic mouse model. Tissue Cell. 2023 Aug; 83:102125.
Miyake K, Han Q, Murakami T, Kiyuna T, Kawaguchi K, Igarashi K, Lwin TM, Miyake M, Yamamoto J, Bouvet M, Endo I, Hoffman RM. PMID: 37320867.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Highly Selective Targeting of Pancreatic Cancer in the Liver with a Near-Infrared Anti-MUC5AC Probe in a PDOX Mouse Model: A Proof-of-Concept Study. J Pers Med. 2023 May 20; 13(5).
Turner MA, Cox KE, Neel N, Amirfakhri S, Nishino H, Clary BM, Hosseini M, Natarajan G, Mallya K, Mohs AM, Hoffman RM, Batra SK, Bouvet M. PMID: 37241027; PMCID: PMC10221372.
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PubMed Mentions:
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Synergy of Combining Methionine Restriction and Chemotherapy: The Disruptive Next Generation of Cancer Treatment. Cancer Diagn Progn. 2023 May-Jun; 3(3):272-281.
Kubota Y, Han Q, Aoki Y, Masaki N, Obara K, Hamada K, Hozumi C, Wong ACW, Bouvet M, Tsunoda T, Hoffman RM. PMID: 37168964; PMCID: PMC10165382.
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PubMed Mentions:
3
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Specific Targeting and Labeling of Colonic Polyps in CPC-APC Mice with Mucin 5AC Fluorescent Antibodies: A Model for Detection of Early Colon Cancer. Curr Issues Mol Biol. 2023 Apr 11; 45(4):3347-3358.
Turner MA, Cox KE, Liu S, Neel N, Amirfakhri S, Nishino H, Hosseini M, Alcantara JA, Abd El-Hafeez AA, Lwin TM, Mallya K, Pisegna JR, Singh SK, Ghosh P, Hoffman RM, Batra SK, Bouvet M. PMID: 37185743; PMCID: PMC10136452.
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PubMed Mentions: Fields:
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Oncogenes and Methionine Addiction of Cancer: Role of c-MYC. Cancer Genomics Proteomics. 2023 Mar-Apr; 20(2):165-170.
Aoki Y, Han Q, Kubota Y, Masaki N, Obara K, Tome Y, Bouvet M, Nishida K, Hoffman RM. PMID: 36870694; PMCID: PMC9989672.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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The Mucin Family of Proteins: Candidates as Potential Biomarkers for Colon Cancer. Cancers (Basel). 2023 Feb 27; 15(5).
Cox KE, Liu S, Lwin TM, Hoffman RM, Batra SK, Bouvet M. PMID: 36900282; PMCID: PMC10000725.
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PubMed Mentions:
6
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Superiority of [11C]methionine over [18F]deoxyglucose for PET Imaging of Multiple Cancer Types Due to the Methionine Addiction of Cancer. Int J Mol Sci. 2023 Jan 18; 24(3).
Kubota Y, Sato T, Hozumi C, Han Q, Aoki Y, Masaki N, Obara K, Tsunoda T, Hoffman RM. PMID: 36768257; PMCID: PMC9915427.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Direct implantation of hair-follicle-associated pluripotent (HAP) stem cells repairs intracerebral hemorrhage and reduces neuroinflammation in mouse model. PLoS One. 2023; 18(1):e0280304.
Obara K, Shirai K, Hamada Y, Arakawa N, Hasegawa A, Takaoka N, Aki R, Hoffman RM, Amoh Y. PMID: 36638123; PMCID: PMC9838830.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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TRAF6 regulates the abundance of RIPK1 and inhibits the RIPK1/RIPK3/MLKL necroptosis signaling pathway and affects the progression of colorectal cancer. Cell Death Dis. 2023 01 05; 14(1):6.
Lin P, Lin C, He R, Chen H, Teng Z, Yao H, Liu S, Hoffman RM, Ye J, Zhu G. PMID: 36604411; PMCID: PMC9816173.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Recombinant Oral Methioninase (o-rMETase) Combined With Oxaliplatinum Plus 5-Fluorouracil Improves Survival of Mice With Massive Colon-Cancer Peritoneal Carcinomatosis. Anticancer Res. 2023 Jan; 43(1):19-24.
Kim MJ, Han Q, Bouvet M, Hoffman RM, Park JH. PMID: 36585181.
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PubMed Mentions:
1 Fields:
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Elevated Pro-inflammatory Cytokine Levels in Acute Reflux Esophagitis Are Reduced by 1,25 Dihydroxy Vitamin D3. In Vivo. 2023 Jan-Feb; 37(1):79-87.
Wei J, Zhang J, Jiang Y, Lian T, Zhang P, Hoffman RM, Zhu G, Zhuang Z. PMID: 36593017.
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PubMed Mentions: Fields:
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ASO Visual Abstract: Proof of Principle of Combining Fluorescence-Guided Surgery with Photoimmunotherapy to Improve the Outcome of Pancreatic Cancer Therapy in an Orthotopic Mouse Model. Ann Surg Oncol. 2023 Jan; 30(1):626-627.
Nishino H, Turner MA, Amirfakhri S, Lwin TM, Hosseini M, Singer BB, Hoffman RM, Bouvet M. PMID: 36056196.
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PubMed Mentions: Fields:
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Synergy of oral recombinant methioninase (rMETase) and 5-fluorouracil on poorly differentiated gastric cancer. Biochem Biophys Res Commun. 2022 Dec 21; 643:48-54.
Miyake M, Miyake K, Han Q, Igarashi K, Kawaguchi K, Barangi M, Kiyuna T, Sugisawa N, Higuchi T, Oshiro H, Zhang Z, Razmjooei S, Bouvet M, Endo I, Hoffman RM. PMID: 36586158.
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PubMed Mentions:
1 Fields:
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Hair follicle associated pluripotent (HAP) stem cells jump from transplanted whiskers to pelage follicles and stimulate hair growth. Sci Rep. 2022 Dec 07; 12(1):21174.
Obara K, Reynoso J, Hamada Y, Aoki Y, Kubota Y, Masaki N, Amoh Y, Hoffman RM. PMID: 36476963.
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PubMed Mentions: Fields:
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Elimination of Axillary-Lymph-Node Metastases in a Patient With Invasive Lobular Breast Cancer Treated by First-line Neo-adjuvant Chemotherapy Combined With Methionine Restriction. Anticancer Res. 2022 Dec; 42(12):5819-5823.
Kubota Y, Han Q, Masaki N, Hozumi C, Hamada K, Aoki Y, Obara K, Tsunoda T, Hoffman RM. PMID: 36456116.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Reversion of methionine addiction of osteosarcoma cells to methionine independence results in loss of malignancy, modulation of the epithelial-mesenchymal phenotype and alteration of histone-H3 lysine-methylation. Front Oncol. 2022; 12:1009548.
Aoki Y, Han Q, Tome Y, Yamamoto J, Kubota Y, Masaki N, Obara K, Hamada K, Wang JD, Inubushi S, Bouvet M, Clarke SG, Nishida K, Hoffman RM. PMID: 36408173; PMCID: PMC9671209.
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PubMed Mentions:
7
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Oral-recombinant Methioninase in Combination With Rapamycin Eradicates Osteosarcoma of the Breast in a Patient-derived Orthotopic Xenograft Mouse Model. Anticancer Res. 2022 Nov; 42(11):5217-5222.
Masaki N, Han Q, Samonte C, Wu NF, Hozumi C, Wu J, Obara K, Kubota Y, Aoki Y, Bouvet M, Hoffman RM. PMID: 36288875.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Oral Installation of Recombinant Methioninase-producing Escherichia coli into the Microbiome Inhibits Colon-cancer Growth in a Syngeneic Mouse Model. Cancer Genomics Proteomics. 2022 Nov-Dec; 19(6):683-691.
Kubota Y, Han Q, Hamada K, Aoki Y, Masaki N, Obara K, Baranov A, Bouvet M, Tsunoda T, Hoffman RM. PMID: 36316039; PMCID: PMC9620449.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Oral-recombinant Methioninase Lowers the Effective Dose and Eliminates Toxicity of Cisplatinum for Primary Osteosarcoma of the Mammary Gland in a Patient-derived Orthotopic Xenograft Mouse Model. In Vivo. 2022 Nov-Dec; 36(6):2598-2603.
Masaki N, Han Q, Wu NF, Samonte C, Wu J, Hozumi C, Obara K, Kubota Y, Aoki Y, Miyazaki J, Hoffman RM. PMID: 36309364.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
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Chloroquine Combined With Rapamycin Arrests Tumor Growth in a Patient-derived Orthotopic Xenograft (PDOX) Mouse Model of Dedifferentiated Liposarcoma. In Vivo. 2022 Nov-Dec; 36(6):2630-2637.
Masaki N, Aoki Y, Kubota Y, Obara K, Miyazaki J, Hoffman RM. PMID: 36309387.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
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Evodiamine inhibits ESCC by inducing M-phase cell-cycle arrest via CUL4A/p53/p21 axis and activating noxa-dependent intrinsic and DR4-dependent extrinsic apoptosis. Phytomedicine. 2023 Jan; 108:154493.
Zhang L, Li L, Chen X, Yuan S, Xu T, Zhao W, Li M, Wang F, Hoffman RM, Jia L. PMID: 36265256.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Long-chain Non-coding RNA MIR4435-2HG Expression Correlates With Size of Intestinal Polyps in Children and With Metastasis of Colon Cancer. Anticancer Res. 2022 Oct; 42(10):4707-4714.
Zhu D, Guo P, Jin XY, Zhang R, Ji G, Yang Z, Hoffman RM, Sheng W. PMID: 36191994.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Micro RNA miR-1303 Promotion of Proliferation, Migration and Invasion of Human Liver Cancer Cells Is Enhanced by Low Talin 1 (TLN1) Expression. Anticancer Res. 2022 Oct; 42(10):4715-4725.
Huang J, Xi Q, Xiong J, Peng H, Yang H, Sun YU, Hoffman RM. PMID: 36192016.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Inhibition of pancreatic cancer-cell growth and metastasis in vivo by a pyrazole compound characterized as a cell-migration inhibitor by an in vitro chemotaxis assay. Biomed Pharmacother. 2022 Nov; 155:113733.
Okamoto S, Miyano K, Choshi T, Sugisawa N, Nishiyama T, Kotouge R, Yamamura M, Sakaguchi M, Kinoshita R, Tomonobu N, Katase N, Sasaki K, Nishina S, Hino K, Kurose K, Oka M, Kubota H, Ueno T, Hirai T, Fujiwara H, Kawai C, Itadani M, Morihara A, Matsushima K, Kanegasaki S, Hoffman RM, Yamauchi A, Kuribayashi F. PMID: 36271542.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Resistance to tyrosine kinase inhibitors promotes renal cancer progression through MCPIP1 tumor-suppressor downregulation and c-Met activation. Cell Death Dis. 2022 Sep 22; 13(9):814.
Marona P, Górka J, Kwapisz O, Jura J, Rys J, Hoffman RM, Miekus K. PMID: 36138026; PMCID: PMC9500022.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells. Signal Transduct Target Ther. 2022 09 09; 7(1):313.
Ni S, Liu Q, Chen X, Ding L, Cai L, Mao F, Shi D, Hoffman RM, Li J, Jia L. PMID: 36075909; PMCID: PMC9458665.
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PubMed Mentions:
1 Fields:
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Proof of Principle of Combining Fluorescence-Guided Surgery with Photoimmunotherapy to Improve the Outcome of Pancreatic Cancer Therapy in an Orthotopic Mouse Model. Ann Surg Oncol. 2023 Jan; 30(1):618-625.
Nishino H, Turner MA, Amirfakhri S, Lwin TM, Hosseini M, Singer BB, Hoffman RM, Bouvet M. PMID: 36057899; PMCID: PMC9726788.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Review: Precise sarcoma patient-derived orthotopic xenograft (PDOX) mouse models enable identification of novel effective combination therapies with the cyclin-dependent kinase inhibitor palbociclib: A strategy for clinical application. Front Oncol. 2022; 12:957844.
Higuchi T, Igarashi K, Yamamoto N, Hayashi K, Kimura H, Miwa S, Bouvet M, Tsuchiya H, Hoffman RM. PMID: 36003796; PMCID: PMC9393494.
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PubMed Mentions:
1
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Proof of concept of improved fluorescence-guided surgery of colon cancer liver metastasis using color-coded imaging of a tumor-labeling fluorescent antibody and indocyanine green restricted to the adjacent liver segment. Surgery. 2022 10; 172(4):1156-1163.
Nishino H, Turner MA, Amirfakhri S, Hollandsworth HM, Lwin TM, Hosseini M, Framery B, Cailler F, Pèlegrin A, Hoffman RM, Bouvet M. PMID: 35927078.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Long-term Stable Disease in a Rectal-cancer Patient Treated by Methionine Restriction With Oral Recombinant Methioninase and a Low-methionine Diet. Anticancer Res. 2022 Aug; 42(8):3857-3861.
Kubota Y, Han Q, Hamada K, Aoki Y, Masaki N, Obara K, Tsunoda T, Hoffman RM. PMID: 35896248.
View in:
PubMed Mentions:
5 Fields:
Translation:
Humans
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Non-invasively Imageable Tibia-tumor-fragment Implantation Experimental-bone-metastasis Mouse Model of GFP-expressing Prostate Cancer. In Vivo. 2022 Jul-Aug; 36(4):1647-1650.
Aoki Y, Masaki N, Tome Y, Kubota Y, Aoki Y, Bouvet M, Nishida K, Hoffman RM. PMID: 35738622; PMCID: PMC9301422.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Obesity Strongly Promotes Growth of Mouse MC38 Colon Cancer in an Orthotopic-syngeneic C57BL/6 Mouse Model. In Vivo. 2022 Jul-Aug; 36(4):1643-1646.
Hamada K, Kubota Y, Aoki Y, Sugisawa N, Yamamoto J, Tashiro Y, Bouvet M, Tsunoda T, Hoffman RM. PMID: 35738603; PMCID: PMC9301442.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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The First Mouse Model of Meckel's Diverticulum Carcinoma. In Vivo. 2022 Jul-Aug; 36(4):1603-1607.
Masaki N, Yonemura Y, Wu NF, Samonte C, Hozumi C, Kubota Y, Aoki Y, Bouvet M, Miyazaki J, Hoffman RM. PMID: 35738609; PMCID: PMC9301432.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Anti-mucin 4 fluorescent antibody brightly targets colon cancer in patient-derived orthotopic xenograft mouse models: A proof-of-concept study for future clinical applications. Am J Surg. 2022 10; 224(4):1081-1085.
Turner MA, Hollandsworth HM, Amirfakhri S, Lwin TM, Nishino H, Neel NC, Natarajan G, Kaur S, Mallya K, Hoffman RM, Batra SK, Bouvet M. PMID: 35715267; PMCID: PMC9987031.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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Fluorescent Anti-CEA Nanobody for Rapid Tumor-Targeting and Imaging in Mouse Models of Pancreatic Cancer. Biomolecules. 2022 05 16; 12(5).
Lwin TM, Turner MA, Nishino H, Amirfakhri S, Hernot S, Hoffman RM, Bouvet M. PMID: 35625638; PMCID: PMC9138244.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
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Hair-follicle-associated pluripotent (HAP) stem cells differentiate into mature beating cardiomyocyte sheets on flexible substrates in vitro. Med Mol Morphol. 2022 Sep; 55(3):248-257.
Takaoka N, Yamane M, Obara K, Shirai K, Aki R, Hamada Y, Arakawa N, Hoffman RM, Amoh Y. PMID: 35536435.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Stage IV Pancreatic Cancer Patient Treated With FOLFIRINOX Combined With Oral Methioninase: A Highly-Rare Case With Long-term Stable Disease. Anticancer Res. 2022 May; 42(5):2567-2572.
Kubota Y, Han Q, Hozumi C, Masaki N, Yamamoto J, Aoki Y, Tsunoda T, Hoffman RM. PMID: 35489727.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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Deletion of MTAP Highly Sensitizes Osteosarcoma Cells to Methionine Restriction With Recombinant Methioninase. Cancer Genomics Proteomics. 2022 May-Jun; 19(3):299-304.
Aoki Y, Tome Y, Han Q, Yamamoto J, Hamada K, Masaki N, Kubota Y, Bouvet M, Nishida K, Hoffman RM. PMID: 35430564; PMCID: PMC9016482.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Guanylate-binding Protein 2 Expression Is Associated With Poor Survival and Malignancy in Clear-cell Renal Cell Carcinoma. Anticancer Res. 2022 May; 42(5):2341-2354.
Liu Q, Hoffman RM, Song J, Miao S, Zhang J, Ding D, Wang D. PMID: 35489720.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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ATR inhibition sensitizes liposarcoma to doxorubicin by increasing DNA damage. Am J Cancer Res. 2022; 12(4):1577-1592.
Cui J, Dean D, Hornicek FJ, Pollock RE, Hoffman RM, Duan Z. PMID: 35530299; PMCID: PMC9077062.
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PubMed Mentions:
2
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Linkage of methionine addiction, histone lysine hypermethylation, and malignancy. iScience. 2022 Apr 15; 25(4):104162.
Yamamoto J, Inubushi S, Han Q, Tashiro Y, Sugisawa N, Hamada K, Aoki Y, Miyake K, Matsuyama R, Bouvet M, Clarke SG, Endo I, Hoffman RM. PMID: 35434545; PMCID: PMC9010622.
View in:
PubMed Mentions:
7
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Indocyanine Green Labeling of Tumors in the Liver Recurring After Radiofrequency Ablation Enables Complete Resection by Fluorescence-guided Surgery. Anticancer Res. 2022 Mar; 42(3):1345-1350.
Tashiro Y, Aoki T, Hirai T, Koizumi T, Kusano T, Matsuda K, Yamada K, Nogaki K, Hakozaki T, Wada Y, Shibata H, Tomioka K, Yamazaki T, Saito K, Fujimori A, Enami Y, Hoffman RM. PMID: 35220226.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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TRAF6 regulates the signaling pathway influencing colorectal cancer function through ubiquitination mechanisms. Cancer Sci. 2022 Apr; 113(4):1393-1405.
Guangwei Z, Zhibin C, Qin W, Chunlin L, Penghang L, Ruofan H, Hui C, Hoffman RM, Jianxin Y. PMID: 35179811; PMCID: PMC8990288.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
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CHFR-Promoter-Methylation Status Is Predictive of Response to Irinotecan-based Systemic Chemotherapy in Advanced Colorectal Cancer. Anticancer Res. 2022 Feb; 42(2):697-707.
Hagiwara T, Sugimoto K, Momose H, Irie T, Honjo K, Okazawa YU, Kawai M, Kawano S, Munakata S, Takahashi M, Kojima Y, Serizawa N, Nagahara A, Hoffman RM, Brock MV, Sakamoto K. PMID: 35093868.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Oral-recombinant Methioninase Converts an Osteosarcoma from Methotrexate-resistant to -sensitive in a Patient-derived Orthotopic-xenograft (PDOX) Mouse Model. Anticancer Res. 2022 Feb; 42(2):731-737.
Aoki Y, Tome Y, Han Q, Yamamoto J, Hamada K, Masaki N, Kubota Y, Bouvet M, Nishida K, Hoffman RM. PMID: 35093871.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimals
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High Incidence of Lymph-node Metastasis in a Pancreatic-cancer Patient-derived Orthotopic Xenograft (PDOX) NOG-Mouse Model. Anticancer Res. 2022 Feb; 42(2):739-743.
Sugisawa N, Miyake K, Higuchi T, Oshiro H, Park JH, Kawaguchi K, Bouvet M, Unno M, Hoffman RM. PMID: 35093872.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
-
Methionine Restriction: Ready for Prime Time in the Cancer Clinic? Anticancer Res. 2022 Feb; 42(2):641-644.
Yamamoto J, Han Q, Simon M, Thomas D, Hoffman RM. PMID: 35093861.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimals
-
Chronic spinal cord injury functionally repaired by direct implantation of encapsulated hair-follicle-associated pluripotent (HAP) stem cells in a mouse model: Potential for clinical regenerative medicine. PLoS One. 2022; 17(1):e0262755.
Obara K, Shirai K, Hamada Y, Arakawa N, Yamane M, Takaoka N, Aki R, Hoffman RM, Amoh Y. PMID: 35085322; PMCID: PMC8794105.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
-
Fluorescence Molecular Targeting of Colon Cancer to Visualize the Invisible. Cells. 2022 01 12; 11(2).
Lwin TM, Turner MA, Amirfakhri S, Nishino H, Hoffman RM, Bouvet M. PMID: 35053365; PMCID: PMC8773892.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimals
-
Andrographolide, a diterpene lactone from the Traditional Chinese Medicine Andrographis paniculate, induces senescence in human lung adenocarcinoma via p53/p21 and Skp2/p27. Phytomedicine. 2022 Apr; 98:153933.
Zhang J, Li C, Zhang L, Heng Y, Wang S, Pan Y, Cai L, Zhang Y, Xu T, Chen X, Hoffman RM, Jia L. PMID: 35121394.
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PubMed Mentions:
2 Fields:
-
Fluorescent Anti-MUC5AC Brightly Targets Pancreatic Cancer in a Patient-derived Orthotopic Xenograft. In Vivo. 2022 Jan-Feb; 36(1):57-62.
Turner MA, Hollandsworth HM, Nishino H, Amirfakhri S, Lwin TM, Lowy AM, Kaur S, Natarajan G, Mallya K, Hoffman RM, Batra SK, Bouvet M. PMID: 34972700; PMCID: PMC8765132.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
-
Extent and Instability of Trimethylation of Histone H3 Lysine Increases With Degree of Malignancy and Methionine Addiction. Cancer Genomics Proteomics. 2022 Jan-Feb; 19(1):12-18.
Yamamoto J, Aoki Y, Inubushi S, Han Q, Hamada K, Tashiro Y, Miyake K, Matsuyama R, Bouvet M, Clarke SG, Endo I, Hoffman RM. PMID: 34949655; PMCID: PMC8717956.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
-
Determinative Structural Features Identified With Probe-based Confocal Endomicroscopy for the Accurate Diagnosis of Gallbladder Malignancy. Anticancer Res. 2022 Jan; 42(1):67-73.
Koizumi T, Aoki T, Yamochi T, Tashiro Y, Yamazaki T, Kusano T, Matsuda K, Wada Y, Shibata H, Saito K, Nogaki K, Hakozaki T, Tomioka K, Hirai T, Fujimori A, Mansour DA, Abbas Gahin AE, Hoffman RM. PMID: 34969710.
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PubMed Mentions: Fields:
Translation:
Humans
-
The cancer-inhibitory effects of proliferating tumor-residing fibroblasts. Biochim Biophys Acta Rev Cancer. 2022 01; 1877(1):188673.
Delinassios JG, Hoffman RM. PMID: 34953931.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
-
The Use of Fluorescent Anti-CEA Antibodies to Label, Resect and Treat Cancers: A Review. Biomolecules. 2021 12 02; 11(12).
Turner MA, Lwin TM, Amirfakhri S, Nishino H, Hoffman RM, Yazaki PJ, Bouvet M. PMID: 34944463; PMCID: PMC8699160.
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PubMed Mentions:
3 Fields:
-
Osteosarcoma Patient-derived Orthotopic Xenograft (PDOX) Models Used to Identify Novel and Effective Therapeutics: A Review. Anticancer Res. 2021 Dec; 41(12):5865-5871.
Higuchi T, Igarashi K, Yamamoto N, Hayashi K, Kimura H, Miwa S, Bouvet M, Tsuchiya H, Hoffman RM. PMID: 34848441.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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A Case of Rare Matrix-producing Triple-negative Breast Carcinoma for Which Drug Response in a Patient-derived Orthotopic Xenograft Mouse Model Was Correlated With Patient Response. Anticancer Res. 2021 Dec; 41(12):6191-6197.
Nomura T, Kurebayashi J, Moriya T, Saito W, Murata T, Yamamoto J, Hozumi C, Hoffman RM. PMID: 34848473.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
-
Histone H3 lysine-trimethylation markers are decreased by recombinant methioninase and increased by methotrexate at concentrations which inhibit methionine-addicted osteosarcoma cell proliferation. Biochem Biophys Rep. 2021 Dec; 28:101177.
Aoki Y, Tome Y, Han Q, Yamamoto J, Hamada K, Masaki N, Bouvet M, Nishida K, Hoffman RM. PMID: 34877414; PMCID: PMC8633566.
View in:
PubMed Mentions:
6
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Salmonella typhimurium A1-R Exquisitely Targets and Arrests a Matrix-producing Triple-negative Breast Carcinoma in a PDOX Model. In Vivo. 2021 Nov-Dec; 35(6):3067-3071.
Hamada K, Aoki Y, Yamamoto J, Hozumi C, Zhao M, Murata T, Sugisawa N, Bouvet M, Tsunoda T, Hoffman RM. PMID: 34697138; PMCID: PMC8627766.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
-
Osteosarcoma of the Breast in a Patient Derived Orthotopic Xenograft (PDOX) Mouse Model Is Arrested by both Cisplatinum and Eribulin. In Vivo. 2021 Nov-Dec; 35(6):3107-3110.
Masaki N, Wu NF, Aoki Y, Yamamoto J, Miyazaki J, Hoffman RM. PMID: 34697141; PMCID: PMC8627742.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
-
Survival Response of Patients With Gastric Cancer Treated With Regional Arterial-Perfusion Chemotherapy Is Correlated With Borrmann Classification. Anticancer Res. 2021 Nov; 41(11):5507-5515.
Ma YE, Liang X, Liu LI, Gao D, Yang T, Hoffman RM, Xu J. PMID: 34732421.
View in:
PubMed Mentions:
1 Fields:
Translation:
Humans
-
Over-methylation of Histone H3 Lysines Is a Common Molecular Change Among the Three Major Types of Soft-tissue Sarcoma in Patient-derived Xenograft (PDX) Mouse Models. Cancer Genomics Proteomics. 2021 Nov-Dec; 18(6):715-721.
Aoki Y, Yamamoto J, Tome Y, Hamada K, Masaki N, Inubushi S, Tashiro Y, Bouvet M, Endo I, Nishida K, Hoffman RM. PMID: 34697064; PMCID: PMC8569816.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
-
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19. Nat Commun. 2021 10 18; 12(1):6055.
Boras B, Jones RM, Anson BJ, Arenson D, Aschenbrenner L, Bakowski MA, Beutler N, Binder J, Chen E, Eng H, Hammond H, Hammond J, Haupt RE, Hoffman R, Kadar EP, Kania R, Kimoto E, Kirkpatrick MG, Lanyon L, Lendy EK, Lillis JR, Logue J, Luthra SA, Ma C, Mason SW, McGrath ME, Noell S, Obach RS, O' Brien MN, O'Connor R, Ogilvie K, Owen D, Pettersson M, Reese MR, Rogers TF, Rosales R, Rossulek MI, Sathish JG, Shirai N, Steppan C, Ticehurst M, Updyke LW, Weston S, Zhu Y, White KM, García-Sastre A, Wang J, Chatterjee AK, Mesecar AD, Frieman MB, Anderson AS, Allerton C. PMID: 34663813; PMCID: PMC8523698.
View in:
PubMed Mentions:
122 Fields:
Translation:
HumansAnimalsCells
-
Anti-inflammatory and Anti-thrombotic Efficacy of Targeted Ultrasound Microbubbles on LPS-induced HUVEC Cells. Anticancer Res. 2021 Oct; 41(10):4761-4769.
Sun J, Pan S, Yu H, Hu H, Sun YU, Yang Z, Hoffman RM, Yuan H. PMID: 34593425.
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PubMed Mentions: Fields:
Translation:
HumansCells
-
Antibiotic Usage Reduced Overall Survival by over 70% in Non-small Cell Lung Cancer Patients on Anti-PD-1 Immunotherapy. Anticancer Res. 2021 Oct; 41(10):4985-4993.
Hamada K, Yoshimura K, Hirasawa Y, Hosonuma M, Murayama M, Narikawa Y, Ariizumi H, Ohkuma R, Shida M, Kubota Y, Matsukuma S, Ishiguro T, Sambe T, Horiike A, Kuramasu A, Wada S, Tsurutani J, Inoue E, Uchida N, Kiuchi Y, Kobayashi S, Hoffman RM, Tsunoda T. PMID: 34593446.
View in:
PubMed Mentions:
10 Fields:
Translation:
Humans
-
The Combination of Cisplatinum and Doxorubicin Regressed Primary Osteosarcoma of the Breast in a PDOX Mouse Model. Anticancer Res. 2021 Oct; 41(10):4715-4718.
Wu NF, Yamamoto J, Aoki Y, Masaki N, Samonte C, Wu J, Bouvet M, Hoffman RM. PMID: 34593419.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
-
Efficacy of Oral Recombinant Methioninase and Eribulin on a PDOX Model of Triple-negative Breast Cancer (TNBC) Liver Metastasis. In Vivo. 2021 Sep-Oct; 35(5):2531-2534.
Lim HI, Sun YU, Han Q, Yamamoto J, Hoffman RM. PMID: 34410939; PMCID: PMC8408690.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
-
Multikinase-Inhibitor Screening in Drug-resistant Osteosarcoma Patient-derived Orthotopic Xenograft Mouse Models Identifies the Clinical Potential of Regorafenib. Cancer Genomics Proteomics. 2021 Sep-Oct; 18(5):637-643.
Higuchi T, Igarashi K, Yamamoto N, Hayashi K, Kimura H, Miwa S, Bouvet M, Tsuchiya H, Hoffman RM. PMID: 34479916; PMCID: PMC8441758.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsPHPublic Health
-
Five-day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers without toxicity in a clinical trial of normal-weight individuals. Clin Transl Med. 2021 08; 11(8):e502.
Jiang Y, Yang X, Dong C, Lu Y, Yin H, Xiao B, Yang X, Chen W, Cheng W, Tian H, Guo L, Hu X, Fang H, Chen W, Li Z, Zhou W, Sun W, Guo X, Li S, Lin Y, He R, Chen X, Liu D, Zhang M, Zhang Y, Zhao H, Zheng P, Seyfried TN, Hoffman RM, Jia W, Ji G, Jia L. PMID: 34459130; PMCID: PMC8320652.
View in:
PubMed Mentions:
5 Fields:
Translation:
Humans
-
Indocyanine Green Fluorescence Image-guided Laparoscopic Hepatectomy Enabled Resection of a Tumor Invisible With Ultrasonography. Anticancer Res. 2021 Aug; 41(8):3867-3869.
Oura K, Aoki T, Tashiro Y, Matsuda K, Koizumi T, Kusano T, Wada Y, Shibata H, Yamashita T, Date H, Ariyoshi T, Goto S, Yamazaki K, Watanabe M, Fujimori A, Enami Y, Otsuka K, Hoffman RM, Murakami M. PMID: 34281847.
View in:
PubMed Mentions:
1 Fields:
Translation:
Humans
-
Rapid tumor-labeling kinetics with a site-specific near-infrared anti-CEA nanobody in a patient-derived orthotopic xenograft mouse model of colon cancer. J Surg Oncol. 2021 Dec; 124(7):1121-1127.
Lwin TM, Turner MA, Amirfakhri S, Nishino H, Debie P, Cosman BC, Hoffman RM, Hernot S, Bouvet M. PMID: 34309885; PMCID: PMC8556245.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
-
Combination of CDK4/6 and mTOR Inhibitors Suppressed Doxorubicin-resistant Osteosarcoma in a Patient-derived Orthotopic Xenograft Mouse Model: A Translatable Strategy for Recalcitrant Disease. Anticancer Res. 2021 Jul; 41(7):3287-3292.
Oshiro H, Tome Y, Miyake K, Higuchi T, Sugisawa N, Kanaya F, Nishida K, Hoffman RM. PMID: 34230123.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
-
A Patient-Derived Orthotopic Xenograft Model of Gastroesophageal-Junction Adenocarcinoma Translated to the Clinic by Tumor-Targeting Fluorescent Antibodies to Carcinoembryonic-Antigen-Related Cell-Adhesion Molecules. In Vivo. 2021 Jul-Aug; 35(4):1959-1963.
Turner MA, Amirfakhri S, Nishino H, Lwin TM, Savides TJ, Reid TR, Singer BB, Hoffman RM, Bouvet M. PMID: 34182469; PMCID: PMC8286470.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
-
The First Mouse Model of Primary Osteosarcoma of the Breast. In Vivo. 2021 Jul-Aug; 35(4):1979-1983.
Wu NF, Wu J, Yamamoto J, Aoki Y, Hozumi C, Bouvet M, Hoffman RM. PMID: 34182472; PMCID: PMC8286515.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
-
Traditional Chinese Medicine Xihuang Wan Inhibited Lewis Lung Carcinoma in a Syngeneic Model, Equivalent to Cytotoxic Chemotherapy, by Altering Multiple Signaling Pathways. In Vivo. 2021 Jul-Aug; 35(4):2005-2014.
Zhang Z, Wang J, Duan H, Liu D, Zhou X, Lin X, Pang H, Sun M, Zhou T, Hoffman RM, Hu K. PMID: 34182475; PMCID: PMC8286502.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
-
Chronic Treatment of an Advanced Prostate-cancer Patient With Oral Methioninase Resulted in Long-term Stabilization of Rapidly Rising PSA Levels. In Vivo. 2021 Jul-Aug; 35(4):2171-2176.
Han Q, Hoffman RM. PMID: 34182494; PMCID: PMC8286516.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
-
Immuno-hyperthermia effected by antibody-conjugated nanoparticles selectively targets and eradicates individual cancer cells. Cell Cycle. 2021 07; 20(13):1221-1230.
Kagawa T, Matsumi Y, Aono H, Ohara T, Tazawa H, Shigeyasu K, Yano S, Takeda S, Komatsu Y, Hoffman RM, Fujiwara T, Kishimoto H. PMID: 34148497; PMCID: PMC8330994.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
-
Effective Tumor Targeting by EphA2-Agonist-Biotin-Streptavidin Conjugates. Molecules. 2021 Jun 17; 26(12).
Udompholkul P, Baggio C, Gambini L, Sun Y, Zhao M, Hoffman RM, Pellecchia M. PMID: 34204178; PMCID: PMC8235110.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
-
Fangchinoline Inhibits Human Esophageal Cancer by Transactivating ATF4 to Trigger Both Noxa-Dependent Intrinsic and DR5-Dependent Extrinsic Apoptosis. Front Oncol. 2021; 11:666549.
Zhang Y, Wang S, Chen Y, Zhang J, Yang J, Xian J, Li L, Zhao H, Hoffman RM, Zhang Y, Jia L. PMID: 34195076; PMCID: PMC8236818.
View in:
PubMed Mentions:
5
-
Hyperthermia generated by magnetic nanoparticles for effective treatment of disseminated peritoneal cancer in an orthotopic nude-mouse model. Cell Cycle. 2021 06; 20(12):1122-1133.
Matsumi Y, Kagawa T, Yano S, Tazawa H, Shigeyasu K, Takeda S, Ohara T, Aono H, Hoffman RM, Fujiwara T, Kishimoto H. PMID: 34110969; PMCID: PMC8265816.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
-
Neddylation Regulates Macrophages and Implications for Cancer Therapy. Front Cell Dev Biol. 2021; 9:681186.
Jiang Y, Li L, Li Y, Liu G, Hoffman RM, Jia L. PMID: 34164400; PMCID: PMC8215544.
View in:
PubMed Mentions:
4
-
Exosome Transfer Between Pancreatic-cancer Cells Is Associated With Metastasis in a Nude-mouse Model. Anticancer Res. 2021 Jun; 41(6):2829-2834.
Ichikawa H, Suetsugu A, Satake T, Aoki H, Kunisada T, Shimizu M, Hoffman RM. PMID: 34083272.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
-
Traditional Chinese Medicine Brucea Javanica Oil Enhances the Efficacy of Anlotinib in a Mouse Model of Liver-Metastasis of Small-cell Lung Cancer. In Vivo. 2021 May-Jun; 35(3):1437-1441.
Peng S, Dong W, Chu Q, Meng J, Yang H, DU Y, Sun YU, Hoffman RM. PMID: 33910820; PMCID: PMC8193324.
View in:
PubMed Mentions:
3 Fields:
Translation:
Animals
-
Efficacy of YAP1-gene Knockdown to Inhibit Alveolar-Epithelial-Cell Senescence and Alleviate Idiopathic Pulmonary Fibrosis (IPF). Cancer Genomics Proteomics. 2021 May-Jun; 18(3 Suppl):451-459.
Xu W, Song W, Wang YU, Zan Y, Zhang M, Li M, Huang Q, Zhao W, Sun YU, Hoffman RM, Wu J. PMID: 33994367; PMCID: PMC8240039.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
-
Andrographolide Induces Noxa-Dependent Apoptosis by Transactivating ATF4 in Human Lung Adenocarcinoma Cells. Front Pharmacol. 2021; 12:680589.
Zhang J, Li C, Zhang L, Heng Y, Xu T, Zhang Y, Chen X, Hoffman RM, Jia L. PMID: 33995110; PMCID: PMC8117100.
View in:
PubMed Mentions:
6
-
An mTOR and VEGFR inhibitor combination arrests a doxorubicin resistant lung metastatic osteosarcoma in a PDOX mouse model. Sci Rep. 2021 04 21; 11(1):8583.
Oshiro H, Tome Y, Miyake K, Higuchi T, Sugisawa N, Kanaya F, Nishida K, Hoffman RM. PMID: 33883561; PMCID: PMC8060249.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimals
-
A Novel Color-Coded Liver Metastasis Mouse Model to Distinguish Tumor and Adjacent Liver Segment. J Surg Res. 2021 08; 264:327-333.
Nishino H, Hollandsworth HM, Amirfakhri S, Tashiro Y, Yamamoto J, Turner MA, Lwin TM, Singer BB, Hoffman RM, Bouvet M. PMID: 33848831; PMCID: PMC8222089.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
-
Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Can Extensively Differentiate to Tyrosine-Hydroxylase-Expressing Dopamine-Secreting Neurons. Cells. 2021 04 10; 10(4).
Yamane M, Takaoka N, Obara K, Shirai K, Aki R, Hamada Y, Arakawa N, Hoffman RM, Amoh Y. PMID: 33920157; PMCID: PMC8069047.
View in:
PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
-
Eribulin Inhibits Osteosarcoma in a Clinically-accurate Bone-tumor-insertion PDOX Mouse Model. Anticancer Res. 2021 Apr; 41(4):1779-1784.
Wu NF, Yamamoto J, Aoki Y, Bouvet M, Hoffman RM. PMID: 33813382.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
-
Oral-recombinant Methioninase Converts an Osteosarcoma from Docetaxel-resistant to -Sensitive in a Clinically-relevant Patient-derived Orthotopic-xenograft (PDOX) Mouse Model. Anticancer Res. 2021 Apr; 41(4):1745-1751.
Aoki Y, Tome Y, Wu NF, Yamamoto J, Hamada K, Han Q, Bouvet M, Nishida K, Hoffman RM. PMID: 33813378.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansAnimals
-
Lowering and Stabilizing PSA Levels in Advanced-prostate Cancer Patients With Oral Methioninase. Anticancer Res. 2021 Apr; 41(4):1921-1926.
Han Q, Hoffman RM. PMID: 33813397.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCellsCTClinical Trials
-
Oral recombinant methioninase combined with paclitaxel arrests recalcitrant ovarian clear cell carcinoma growth in a patient-derived orthotopic xenograft (PDOX) nude-mouse model. Cancer Chemother Pharmacol. 2021 07; 88(1):61-67.
Sugisawa N, Higuchi T, Han Q, Hozumi C, Yamamoto J, Tashiro Y, Nishino H, Kawaguchi K, Bouvet M, Murata T, Unno M, Hoffman RM. PMID: 33768300.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
-
Overexpressed NEDD8 as a potential therapeutic target in esophageal squamous cell carcinoma. Cancer Biol Med. 2021 Mar 18.
Xian J, Wang S, Jiang Y, Li L, Cai L, Chen P, Liu Y, Zeng X, Chen G, Ding C, Hoffman RM, Jia L, Zhao H, Zhang Y. PMID: 33733647; PMCID: PMC9088192.
View in:
PubMed Mentions:
2 Fields:
-
The Anti-oxidant Monoterpene p-Cymene Reduced the Occurrence of Colorectal Cancer in a Hyperlipidemia Rat Model by Reducing Oxidative Stress and Expression of Inflammatory Cytokines. Anticancer Res. 2021 Mar; 41(3):1213-1218.
Wang S, Wang X, Wang YU, Leng Q, Sun YU, Hoffman RM, Jin H. PMID: 33788712.
View in:
PubMed Mentions:
6 Fields:
Translation:
Animals
-
The Experience of Greece as a Model to Contain COVID-19 Infection Spread. In Vivo. 2021 Mar-Apr; 35(2):1285-1294.
Delinasios GJ, Fragkou PC, Gkirmpa AM, Tsangaris G, Hoffman RM, Anagnostopoulos AK. PMID: 33622932; PMCID: PMC8045105.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCellsPHPublic Health
-
Combination Methionine-methylation-axis Blockade: A Novel Approach to Target the Methionine Addiction of Cancer. Cancer Genomics Proteomics. 2021 Mar-Apr; 18(2):113-120.
Higuchi T, Han Q, Sugisawa N, Yamamoto J, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 33608308; PMCID: PMC7943212.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
-
Unique Benefits of Tumor-Specific Nanobodies for Fluorescence Guided Surgery. Biomolecules. 2021 02 18; 11(2).
Lwin TM, Hoffman RM, Bouvet M. PMID: 33670740; PMCID: PMC7921980.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
-
A Novel Orthotopic Mouse Model of Lung Metastasis Using Fluorescent Patient-derived Osteosarcoma Cells. Anticancer Res. 2021 Feb; 41(2):635-640.
Oshiro H, Tome Y, Miyake K, Higuchi T, Sugisawa N, Park JH, Zhang Z, Razmjooei S, Kanaya F, Nishida K, Hoffman RM. PMID: 33517267.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
-
Reversion from Methionine Addiction to Methionine Independence Results in Loss of Tumorigenic Potential of Highly-malignant Lung-cancer Cells. Anticancer Res. 2021 Feb; 41(2):641-643.
Yamamoto J, Aoki Y, Han Q, Sugisawa N, Sun YU, Hamada K, Nishino H, Inubushi S, Miyake K, Matsuyama R, Bouvet M, Endo I, Hoffman RM. PMID: 33517268.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
-
Real-Time Fluorescence Image-Guided Oncolytic Virotherapy for Precise Cancer Treatment. Int J Mol Sci. 2021 Jan 17; 22(2).
Yano S, Tazawa H, Kishimoto H, Kagawa S, Fujiwara T, Hoffman RM. PMID: 33477279; PMCID: PMC7830621.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
-
Color-Coded Imaging of Cancer and Stromal-Cell Interaction in the Pancreatic-Cancer Tumor Microenvironment (TME). Methods Mol Biol. 2021; 2224:99-111.
Suetsugu A, Hoffman RM. PMID: 33606209.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
-
A Novel Procedure for Orthotopic Tibia Implantation for Establishment of a More Clinical Osteosarcoma PDOX Mouse Model. In Vivo. 2021 Jan-Feb; 35(1):105-109.
Wu NF, Yamamoto J, Bouvet M, Hoffman RM. PMID: 33402455; PMCID: PMC7880751.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
-
Triple-Methyl Blockade With Recombinant Methioninase, Cycloleucine, and Azacitidine Arrests a Pancreatic Cancer Patient-Derived Orthotopic Xenograft Model. Pancreas. 2021 01 01; 50(1):93-98.
Sugisawa N, Yamamoto J, Han Q, Tan Y, Tashiro Y, Nishino H, Inubushi S, Hamada K, Kawaguchi K, Unno M, Bouvet M, Hoffman RM. PMID: 33370029.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
-
Color-Coded Imaging of the Tumor Microenvironment (TME) in Human Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models. Adv Exp Med Biol. 2021; 1329:163-179.
Suetsugu A, Hoffman RM. PMID: 34664239.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
-
A Universal Gelfoam 3-D Histoculture Method to Establish Patient-derived Cancer Cells (3D-PDCC) Without Fibroblasts from Patient-derived Xenografts. Anticancer Res. 2020 Dec; 40(12):6765-6768.
Yamamoto J, Sugisawa N, Hamada K, Nishino H, Miyake K, Matsuyama R, Inubushi S, Tanino H, Bouvet M, Endo I, Hoffman RM. PMID: 33288569.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
-
View in:
PubMed Mentions:
5 Fields:
Translation:
Humans
-
A novel patient-derived orthotopic xenograft (PDOX) mouse model of highly-aggressive liver metastasis for identification of candidate effective drug-combinations. Sci Rep. 2020 11 18; 10(1):20105.
Zhang Z, Hu K, Miyake K, Kiyuna T, Oshiro H, Wangsiricharoen S, Kawaguchi K, Higuchi T, Razmjooei S, Miyake M, Chawla SP, Singh SR, Hoffman RM. PMID: 33208807; PMCID: PMC7676248.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimals
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A Non-invasive Imageable GFP-expressing Mouse Model of Orthotopic Human Bladder Cancer. In Vivo. 2020 Nov-Dec; 34(6):3225-3231.
Sun YU, Nishino H, Zhao M, Miyake K, Sugisawa N, Yamamoto J, Tashiro Y, Inubushi S, Hamada K, Zhu G, Lim H, Hoffman RM. PMID: 33144427; PMCID: PMC7811621.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Co-implantation of Tumor and Extensive Surrounding Tissue Improved the Establishment Rate of Surgical Specimens of Human-Patient Cancer in Nude Mice: Toward the Goal of Universal Individualized Cancer Therapy. In Vivo. 2020 Nov-Dec; 34(6):3241-3245.
Murata T, Hozumi C, Hiroshima Y, Shimoya K, Hongo A, Inubushi S, Tanino H, Hoffman RM. PMID: 33144429; PMCID: PMC7811650.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Sutureless Surgical Orthotopic Implantation Technique of Primary and Metastatic Cancer in the Liver of Mouse Models. In Vivo. 2020 Nov-Dec; 34(6):3153-3157.
Nishino H, Hollandsworth HM, Sugisawa N, Yamamoto J, Tashiro Y, Inubushi S, Hamada K, Sun YU, Lim H, Amirfakhri S, Filemoni F, Hoffman RM, Bouvet M. PMID: 33144418; PMCID: PMC7811661.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
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Ligation Method to Specifically Label a Liver Segment With Indocyanine Green in an Orthotopic Nude-Mouse Liver-Metastasis Model. In Vivo. 2020 Nov-Dec; 34(6):3159-3162.
Nishino H, Hollandsworth HM, Tashiro Y, Yamamoto J, Amirfakhri S, Filemoni F, Sugisawa N, Hoffman RM, Bouvet M. PMID: 33144419; PMCID: PMC7811678.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Response of Triple-negative Breast Cancer Liver Metastasis to Oral Recombinant Methioninase in a Patient-derived Orthotopic Xenograft (PDOX) Model. In Vivo. 2020 Nov-Dec; 34(6):3163-3169.
Lim HI, Yamamoto J, Han Q, Sun YU, Nishino H, Tashiro Y, Sugisawa N, Tan Y, Choi HJ, Nam SJ, Bouvet M, Hoffman RM. PMID: 33144420; PMCID: PMC7811664.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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Oral Recombinant Methioninase Sensitizes a Bladder Cancer Orthotopic Xenograft Mouse Model to Low-dose Cisplatinum and Prevents Metastasis. Anticancer Res. 2020 Nov; 40(11):6083-6091.
Sun YU, Nishino H, Sugisawa N, Yamamoto J, Hamada K, Zhu G, Lim HI, Hoffman RM. PMID: 33109546.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Ischemia reperfusion-induced metastasis is resistant to PPARγ agonist pioglitazone in a murine model of colon cancer. Sci Rep. 2020 10 29; 10(1):18565.
Tashiro Y, Nishino H, Higuchi T, Sugisawa N, Fukuda Y, Yamamoto J, Inubushi S, Aoki T, Murakami M, Singh SR, Bouvet M, Hoffman RM. PMID: 33122687; PMCID: PMC7596558.
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PubMed Mentions: Fields:
Translation:
Animals
-
Histone methylation status of H3K4me3 and H3K9me3 under methionine restriction is unstable in methionine-addicted cancer cells, but stable in normal cells. Biochem Biophys Res Commun. 2020 12 17; 533(4):1034-1038.
Yamamoto J, Han Q, Inubushi S, Sugisawa N, Hamada K, Nishino H, Miyake K, Kumamoto T, Matsuyama R, Bouvet M, Endo I, Hoffman RM. PMID: 33019978.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansCells
-
Prostate Cancer Metastases Are Strongly Inhibited by Agonistic Epha2 Ligands in an Orthotopic Mouse Model. Cancers (Basel). 2020 Oct 02; 12(10).
Salem AF, Gambini L, Billet S, Sun Y, Oshiro H, Zhao M, Hoffman RM, Bhowmick NA, Pellecchia M. PMID: 33023262; PMCID: PMC7600344.
View in:
PubMed Mentions:
8
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A Gemcitabine Plus 5-Fluorouracil Combination Inhibits Gastric-Cancer Liver Metastasis in a PDOX Model: A Novel Treatment Strategy. Anticancer Res. 2020 Oct; 40(10):5393-5397.
Sugisawa N, Nishino H, Higuchi T, Park JH, Yamamoto J, Tashiro Y, Kawaguchi K, Bouvet M, Unno M, Hoffman RM. PMID: 32988858.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
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Fluorescence-guided hepatobiliary surgery with long and short wavelength fluorophores. Hepatobiliary Surg Nutr. 2020 Oct; 9(5):615-639.
Lwin TM, Hoffman RM, Bouvet M. PMID: 33163512; PMCID: PMC7603922.
View in:
PubMed Mentions:
8
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FUCCI Real-Time Cell-Cycle Imaging as a Guide for Designing Improved Cancer Therapy: A Review of Innovative Strategies to Target Quiescent Chemo-Resistant Cancer Cells. Cancers (Basel). 2020 Sep 17; 12(9).
Yano S, Tazawa H, Kagawa S, Fujiwara T, Hoffman RM. PMID: 32957652; PMCID: PMC7563319.
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PubMed Mentions:
5
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Adjuvant Oral Recombinant Methioninase Inhibits Lung Metastasis in a Surgical Breast-Cancer Orthotopic Syngeneic Model. Anticancer Res. 2020 Sep; 40(9):4869-4874.
Sugisawa N, Hamada K, Han Q, Yamamoto J, Sun YU, Nishino H, Kawaguchi K, Bouvet M, Unno M, Hoffman RM. PMID: 32878774.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
Brucea javanica Increases Survival and Enhances Gemcitabine Efficacy in a Patient-derived Orthotopic Xenograft (PDOX) Mouse Model of Pancreatic Cancer. Anticancer Res. 2020 Sep; 40(9):4969-4978.
Yang H, Tong Z, Shen L, Sun YU, Hoffman RM, Huang J. PMID: 32878785.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Indocyanine Green Labels an Orthotopic Nude-Mouse Model of Very-Early Colon-Cancer Liver Metastases. In Vivo. 2020 Sep-Oct; 34(5):2277-2280.
Tashiro Y, Hollandsworth HM, Nishino H, Yamamoto J, Amirfakhri S, Filemoni F, Sugisawa N, Aoki T, Murakami M, Hoffman RM, Bouvet M. PMID: 32871750; PMCID: PMC7652533.
View in:
PubMed Mentions:
4 Fields:
Translation:
Animals
-
Oral Methioninase Inhibits Recurrence in a PDOX Mouse Model of Aggressive Triple-negative Breast Cancer. In Vivo. 2020 Sep-Oct; 34(5):2281-2286.
Lim HI, Hamada K, Yamamoto J, Han Q, Tan Y, Choi HJ, Nam SJ, Bouvet M, Hoffman RM. PMID: 32871751; PMCID: PMC7652477.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimals
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Humanized Fluorescent Tumor-associated Glycoprotein-72 Antibody Selectively Labels Colon-cancer Liver Metastases in Orthotopic Mouse Models. In Vivo. 2020 Sep-Oct; 34(5):2303-2307.
Hollandsworth HM, Nishino H, Turner M, Amirfakhri S, Filemoni F, Hoffman RM, Yazaki PJ, Bouvet M. PMID: 32871754; PMCID: PMC7652487.
View in:
PubMed Mentions:
2 Fields:
Translation:
Animals
-
An Improved Encapsulation Method for Cryopreserving Hepatocytes for Functional Transplantation Using a Thermo-reversible Gelation Polymer. In Vivo. 2020 Sep-Oct; 34(5):2309-2316.
Yamada K, Aoki T, Enami Y, Tashiro Y, Zehaou Z, Koizumi T, Kusano T, Matsuda K, Wada Y, Shibata H, Tomioka K, Siriratsivawong K, Hoffman RM, Murakami M. PMID: 32871755; PMCID: PMC7652459.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Fluorophore-conjugated Helicobacter pylori recombinant membrane protein (HopQ) labels primary colon cancer and metastases in orthotopic mouse models by binding CEA-related cell adhesion molecules. Transl Oncol. 2020 Dec; 13(12):100857.
Hollandsworth HM, Schmitt V, Amirfakhri S, Filemoni F, Schmidt A, Landström M, Lyndin M, Backert S, Gerhard M, Wennemuth G, Hoffman RM, Singer BB, Bouvet M. PMID: 32866936; PMCID: PMC7475271.
View in:
PubMed Mentions:
3
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Oral recombinant methioninase increases TRAIL receptor-2 expression to regress pancreatic cancer in combination with agonist tigatuzumab in an orthotopic mouse model. Cancer Lett. 2020 11 01; 492:174-184.
Yamamoto J, Miyake K, Han Q, Tan Y, Inubushi S, Sugisawa N, Higuchi T, Tashiro Y, Nishino H, Homma Y, Matsuyama R, Chawla SP, Bouvet M, Singh SR, Endo I, Hoffman RM. PMID: 32739322.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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The identification of candidate effective combination regimens for pancreatic cancer using the histoculture drug response assay. Sci Rep. 2020 07 20; 10(1):12004.
Jun E, Park Y, Lee W, Kwon J, Lee S, Kim MB, Lee JS, Song KB, Hwang DW, Lee JH, Hoffman RM, Kim SC. PMID: 32686712; PMCID: PMC7371642.
View in:
PubMed Mentions:
2 Fields:
Translation:
Humans
-
NEDD8-conjugating enzyme UBC12 as a novel therapeutic target in esophageal squamous cell carcinoma. Signal Transduct Target Ther. 2020 07 10; 5(1):123.
Wang S, Xian J, Li L, Jiang Y, Liu Y, Cai L, Hoffman RM, Jia L, Zhao H, Zhang Y. PMID: 32651357; PMCID: PMC7351728.
View in:
PubMed Mentions:
7 Fields:
Translation:
Humans
-
Osimertinib regressed an EGFR-mutant lung-adenocarcinoma bone-metastasis mouse model and increased long-term survival. Transl Oncol. 2020 Oct; 13(10):100826.
Higuchi T, Sugisawa N, Park JH, Sun Y, Zhu G, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 32659740; PMCID: PMC7356269.
View in:
PubMed Mentions:
4
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Pathological Validity of Using Near-infrared Fluorescence Imaging for Securing Surgical Margins During Liver Resection. Anticancer Res. 2020 Jul; 40(7):3873-3882.
Tashiro Y, Aoki T, Hirai T, Koizumi T, Mansou DA, Kusano T, Matsuda K, Yamada K, Nogaki K, Hakozaki T, Wada Y, Shibata H, Tomioka K, Yamazaki T, Saito K, Fujimori A, Enami Y, Hoffman RM, Murakami M. PMID: 32620627.
View in:
PubMed Mentions:
7 Fields:
Translation:
Humans
-
Eribulin Regresses a Doxorubicin-resistant Dedifferentiated Liposarcoma in a Patient-derived Orthotopic Xenograft Mouse Model. Cancer Genomics Proteomics. 2020 Jul-Aug; 17(4):351-358.
Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Higuchi T, Yamamoto N, Hayashi K, Kimura H, Miwa S, Singh SR, Tsuchiya H, Hoffman RM. PMID: 32576580; PMCID: PMC7367606.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Near-infrared photoimmunotherapy is effective treatment for colorectal cancer in orthotopic nude-mouse models. PLoS One. 2020; 15(6):e0234643.
Hollandsworth HM, Amirfakhri S, Filemoni F, Molnar J, Hoffman RM, Yazaki P, Bouvet M. PMID: 32555717; PMCID: PMC7302706.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Oral Methioninase for Covid-19 Methionine-restriction Therapy. In Vivo. 2020 Jun; 34(3 Suppl):1593-1596.
Hoffman RM, Han Q. PMID: 32503816; PMCID: PMC8378026.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCellsPHPublic Health
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Oncogenic miRNAs Identified in Tear Exosomes From Metastatic Breast Cancer Patients. Anticancer Res. 2020 06; 40(6):3091-3096.
Inubushi S, Kawaguchi H, Mizumoto S, Kunihisa T, Baba M, Kitayama Y, Takeuchi T, Hoffman RM, Sasaki R. PMID: 32487603.
View in:
PubMed Mentions:
37 Fields:
Translation:
HumansCells
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The future of tumour-specific fluorescence-guided surgery for pancreatic cancer. Lancet Gastroenterol Hepatol. 2020 08; 5(8):715-717.
Lwin TM, Hoffman RM, Bouvet M. PMID: 32416765.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Myc is a prognostic biomarker and potential therapeutic target in osteosarcoma. Ther Adv Med Oncol. 2020; 12:1758835920922055.
Feng W, Dean DC, Hornicek FJ, Spentzos D, Hoffman RM, Shi H, Duan Z. PMID: 32426053; PMCID: PMC7222246.
View in:
PubMed Mentions:
30
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Tumor-specific near-infrared nanobody probe rapidly labels tumors in an orthotopic mouse model of pancreatic cancer. Surgery. 2020 07; 168(1):85-91.
Lwin TM, Hernot S, Hollandsworth H, Amirfakhri S, Filemoni F, Debie P, Hoffman RM, Bouvet M. PMID: 32370916; PMCID: PMC7311276.
View in:
PubMed Mentions:
9 Fields:
Translation:
Animals
-
Oral Recombinant Methioninase Inhibits Diabetes Onset in Mice on a High-fat Diet. In Vivo. 2020 May-Jun; 34(3):973-978.
Tashiro Y, Han Q, Tan Y, Sugisawa N, Yamamoto J, Nishino H, Inubushi S, Sun YU, Zhu G, Lim H, Aoki T, Murakami M, Bouvet M, Hoffman RM. PMID: 32354882; PMCID: PMC7279799.
View in:
PubMed Mentions:
2 Fields:
Translation:
Animals
-
A Novel Anionic-phosphate-platinum Complex Effectively Targets a Cisplatinum-resistant Osteosarcoma in a Patient-derived Orthotopic Xenograft Mouse Model. Cancer Genomics Proteomics. 2020 May-Jun; 17(3):217-223.
Igarashi K, Kawaguchi K, Yamamoto N, Hayashi K, Kimura H, Miwa S, Higuchi T, Taniguchi Y, Yonezawa H, Araki Y, Morinaga S, Misra S, Nelson SD, Dry SM, Li Y, Odani A, Singh SR, Tsuchiya H, Hoffman RM. PMID: 32345663; PMCID: PMC7259888.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Recombinant Methioninase Combined With Tumor-targeting Salmonella typhimurium A1-R Induced Regression in a PDOX Mouse Model of Doxorubicin-resistant Dedifferentiated Liposarcoma. Anticancer Res. 2020 May; 40(5):2515-2523.
Igarashi K, Kawaguchi K, Zhao M, Han Q, Tan Y, Kiyuna T, Miyake K, Higuchi T, Nelson SD, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Singh SR, Tsuchiya H, Hoffman RM. PMID: 32366396.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Oral Recombinant Methioninase Prevents Nonalcoholic Fatty Liver Disease in Mice on a High Fat Diet. In Vivo. 2020 May-Jun; 34(3):979-984.
Tashiro Y, Han Q, Tan Y, Sugisawa N, Yamamoto J, Nishino H, Inubushi S, Sun YU, Lim H, Aoki T, Murakami M, Takahashi Y, Bouvet M, Hoffman RM. PMID: 32354883; PMCID: PMC7279815.
View in:
PubMed Mentions:
1 Fields:
Translation:
Animals
-
Comparison of the Efficacy of EGFR Tyrosine Kinase Inhibitors Erlotinib and Low-dose Osimertinib on a PC-9-GFP EGFR Mutant Non-small-cell Lung Cancer Growing in the Brain of Nude Mice. In Vivo. 2020 May-Jun; 34(3):1027-1030.
Katsuya Y, Miyake K, Higuchi T, Oshiro H, Sugisawa N, Singh SR, Goto Y, Zhao M, Hoffman RM. PMID: 32354888; PMCID: PMC7279826.
View in:
PubMed Mentions: Fields:
Translation:
AnimalsCells
-
Eribulin Regresses a Cisplatinum-resistant Rare-type Triple-negative Matrix-producing Breast Carcinoma Patient-derived Orthotopic Xenograft Mouse Model. Anticancer Res. 2020 May; 40(5):2475-2479.
Yamamoto J, Murata T, Sugisawa N, Higuchi T, Tashiro Y, Nishino H, Inubushi S, Sun YU, Lim H, Miyake K, Shimoya K, Nomura T, Kurebayashi J, Tanino H, Hozumi C, Bouvet M, Singh SR, Endo I, Hoffman RM. PMID: 32366391.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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A Single Low Dose of Eribulin Regressed a Highly Aggressive Triple-negative Breast Cancer in a Patient-derived Orthotopic Xenograft Model. Anticancer Res. 2020 May; 40(5):2481-2485.
Lim HI, Yamamoto J, Inubushi S, Nishino H, Tashiro Y, Sugisawa N, Han Q, Sun YU, Choi HJ, Nam SJ, Kim MB, Lee JS, Hozumi C, Bouvet M, Singh SR, Hoffman RM. PMID: 32366392.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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A Triple-negative Matrix-producing Breast Carcinoma Patient-derived Orthotopic Xenograft (PDOX) Mouse Model Is Sensitive to Bevacizumab and Vinorelbine, Regressed by Eribulin and Resistant to Olaparib. Anticancer Res. 2020 May; 40(5):2509-2514.
Yamamoto J, Murata T, Tashiro Y, Higuchi T, Sugisawa N, Nishino H, Inubushi S, Sun YU, Lim H, Miyake K, Hongo A, Nomura T, Saitoh W, Moriya T, Tanino H, Hozumi C, Bouvet M, Singh SR, Endo I, Hoffman RM. PMID: 32366395.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Oral dosing of Recombinant Methioninase Is Associated With a 70% Drop in PSA in a Patient With Bone-metastatic Prostate Cancer and 50% Reduction in Circulating Methionine in a High-stage Ovarian Cancer Patient. Anticancer Res. 2020 May; 40(5):2813-2819.
Han Q, Tan Y, Hoffman RM. PMID: 32366428.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimals
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Humanized Anti-Tumor-Associated Glycoprotein-72 for Submillimeter Near-Infrared Detection of Colon Cancer in Metastatic Mouse Models. J Surg Res. 2020 08; 252:16-21.
Hollandsworth HM, Amirfakhri S, Filemoni F, Hoffman RM, Molnar J, Yazaki PJ, Bouvet M. PMID: 32217350; PMCID: PMC7295682.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Temozolomide and Pazopanib Combined with FOLFOX Regressed a Primary Colorectal Cancer in a Patient-derived Orthotopic Xenograft Mouse Model. Transl Oncol. 2020 Mar; 13(3):100739.
Zhu G, Zhao M, Han Q, Tan Y, Sun Y, Bouvet M, Clary B, Singh SR, Ye J, Hoffman RM. PMID: 32143177; PMCID: PMC7058405.
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PubMed Mentions:
2
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Oral Recombinant Methioninase Prevents Obesity in Mice on a High-fat Diet. In Vivo. 2020 Mar-Apr; 34(2):489-494.
Tashiro Y, Han Q, Tan Y, Sugisawa N, Yamamoto J, Nishino H, Inubushi S, Higuchi T, Aoki T, Murakami M, Hoffman RM. PMID: 32111745; PMCID: PMC7157881.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimals
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Pazopanib Inhibits Tumor Growth, Lymph-node Metastasis and Lymphangiogenesis of an Orthotopic Mouse of Colorectal Cancer. Cancer Genomics Proteomics. 2020 Mar-Apr; 17(2):131-139.
Zhu G, Zhao M, Han Q, Tan Y, Sun YU, Bouvet M, Singh SR, Ye J, Hoffman RM. PMID: 32108035; PMCID: PMC7078832.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
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APELA/ELA32 Reduces Iodixanol-induced Apoptosis, Inflammatory Response and Mitochondrial and DNA Damage in Renal Tubular Epithelial Cells. Anticancer Res. 2020 Feb; 40(2):635-643.
Li Y, Huang J, He S, Lu Z, Zhang J, Li X, Yang Z, Hoffman RM, Wu Q. PMID: 32014904.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Anti-carcinoembryonic antigen-related cell adhesion molecule antibody for fluorescence visualization of primary colon cancer and metastases in patient-derived orthotopic xenograft mouse models. Oncotarget. 2020 Jan 28; 11(4):429-439.
Hollandsworth HM, Amirfakhri S, Filemoni F, Schmitt V, Wennemuth G, Schmidt A, Hoffman RM, Singer BB, Bouvet M. PMID: 32064046; PMCID: PMC6996915.
View in:
PubMed Mentions:
15 Fields:
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Effective targeting of the ubiquitin-like modifier NEDD8 for lung adenocarcinoma treatment. Cell Biol Toxicol. 2020 08; 36(4):349-364.
Jiang Y, Cheng W, Li L, Zhou L, Liang Y, Zhang W, Chen W, Wang S, Zhao H, Chen G, Zhou W, Ji G, Zhang Y, Hoffman RM, Wang M, Jia L. PMID: 31907687.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Collective cancer invasion forms an integrin-dependent radioresistant niche. J Exp Med. 2020 01 06; 217(1).
Haeger A, Alexander S, Vullings M, Kaiser FMP, Veelken C, Flucke U, Koehl GE, Hirschberg M, Flentje M, Hoffman RM, Geissler EK, Kissler S, Friedl P. PMID: 31658985; PMCID: PMC7037234.
View in:
PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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TRAF6-Mediated Inflammatory Cytokines Secretion in LPS-induced Colorectal Cancer Cells Is Regulated by miR-140. Cancer Genomics Proteomics. 2020 Jan-Feb; 17(1):23-33.
Zhu G, Lin C, Cheng Z, Wang Q, Hoffman RM, Singh SR, Huang Y, Zheng W, Yang S, Ye J. PMID: 31882548; PMCID: PMC6937127.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansCells
-
PPARγ Agonist Pioglitazone in Combination With Cisplatinum Arrests a Chemotherapy-resistant Osteosarcoma PDOX Model. Cancer Genomics Proteomics. 2020 Jan-Feb; 17(1):35-40.
Higuchi T, Yamamoto J, Sugisawa N, Tashiro Y, Nishino H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31882549; PMCID: PMC6937125.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Relevance of Vitamin D in Melanoma Development, Progression and Therapy. Anticancer Res. 2020 Jan; 40(1):473-489.
Brozyna AA, Hoffman RM, Slominski AT. PMID: 31892603; PMCID: PMC6948187.
View in:
PubMed Mentions:
26 Fields:
Translation:
Humans
-
Exquisite Tumor Targeting by Salmonella A1-R in Combination with Caffeine and Valproic Acid Regresses an Adult Pleomorphic Rhabdomyosarcoma Patient-Derived Orthotopic Xenograft Mouse Model. Transl Oncol. 2020 Feb; 13(2):393-400.
Igarashi K, Kawaguchi K, Zhao M, Kiyuna T, Miyake K, Miyake M, Nelson SD, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Higuchi T, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31896528; PMCID: PMC6940643.
View in:
PubMed Mentions:
7
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Combination of oral recombinant methioninase and decitabine arrests a chemotherapy-resistant undifferentiated soft-tissue sarcoma patient-derived orthotopic xenograft mouse model. Biochem Biophys Res Commun. 2020 02 26; 523(1):135-139.
Higuchi T, Han Q, Miyake K, Oshiro H, Sugisawa N, Tan Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31839218.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimals
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Combination of Trabectedin With Irinotecan, Leucovorin and 5-Fluorouracil Arrests Primary Colorectal Cancer in an Imageable Patient-derived Orthotopic Xenograft Mouse Model. Anticancer Res. 2019 Dec; 39(12):6463-6470.
Zhu G, Zhao M, Han Q, Tan Y, Sun YU, Bouvet M, Clary B, Singh SR, Ye J, Hoffman RM. PMID: 31810910.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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The combination of oral-recombinant methioninase and azacitidine arrests a chemotherapy-resistant osteosarcoma patient-derived orthotopic xenograft mouse model. Cancer Chemother Pharmacol. 2020 02; 85(2):285-291.
Higuchi T, Sugisawa N, Yamamoto J, Oshiro H, Han Q, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Tan Y, Kuchipudi S, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31705268.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimals
-
Double-negative T Cells Inhibit Proliferation and Invasion of Human Pancreatic Cancer Cells in Co-culture. Anticancer Res. 2019 Nov; 39(11):5911-5918.
Lu Y, Hu P, Zhou H, Yang Z, Sun YU, Hoffman RM, Chen J. PMID: 31704815.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
-
Aurora-A/NF-ĸB Signaling Is Associated With Radio-resistance in Human Lung Adenocarcinoma. Anticancer Res. 2019 Nov; 39(11):5991-5998.
Liu JB, Hu L, Yang Z, Sun YU, Hoffman RM, Yi Z. PMID: 31704824.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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MyD88 Regulates LPS-induced NF-ĸB/MAPK Cytokines and Promotes Inflammation and Malignancy in Colorectal Cancer Cells. Cancer Genomics Proteomics. 2019 Nov-Dec; 16(6):409-419.
Zhu G, Cheng Z, Lin C, Hoffman RM, Huang Y, Singh SR, Zheng W, Yang S, Ye J. PMID: 31659096; PMCID: PMC6885359.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Robo1-specific CAR-NK Immunotherapy Enhances Efficacy of 125I Seed Brachytherapy in an Orthotopic Mouse Model of Human Pancreatic Carcinoma. Anticancer Res. 2019 Nov; 39(11):5919-5925.
Xia N, Haopeng P, Gong JU, Lu J, Chen Z, Zheng Y, Wang Z, Sun YU, Yang Z, Hoffman RM, Liu F. PMID: 31704816.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Combination of Trabectedin With Oxaliplatinum and 5-Fluorouracil Arrests a Primary Colorectal Cancer in a Patient-derived Orthotopic Xenograft Mouse Model. Anticancer Res. 2019 Nov; 39(11):5999-6005.
Zhu G, Zhao M, Han Q, Tan Y, Sun YU, Bouvet M, Singh SR, Ye J, Hoffman RM. PMID: 31704825.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Novel targets identified by integrated cancer-stromal interactome analysis of pancreatic adenocarcinoma. Cancer Lett. 2020 01 28; 469:217-227.
Hiroshima Y, Kasajima R, Kimura Y, Komura D, Ishikawa S, Ichikawa Y, Bouvet M, Yamamoto N, Oshima T, Morinaga S, Singh SR, Hoffman RM, Endo I, Miyagi Y. PMID: 31669204.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Patient-derived orthotopic xenograft models of sarcoma. Cancer Lett. 2020 01 28; 469:332-339.
Igarashi K, Kawaguchi K, Murakami T, Miyake K, Kiyuna T, Miyake M, Hiroshima Y, Higuchi T, Oshiro H, Nelson SD, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31639427.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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Induction of Metastasis by Low-dose Gemcitabine in a Pancreatic Cancer Orthotopic Mouse Model: An Opposite Effect of Chemotherapy. Anticancer Res. 2019 Oct; 39(10):5339-5344.
Sugisawa N, Miyake K, Higuchi T, Oshiro H, Zhang Z, Park JH, Kawaguchi K, Chawla SP, Bouvet M, Singh SR, Unno M, Hoffman RM. PMID: 31570427.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Oral recombinant methioninase combined with oxaliplatinum and 5-fluorouracil regressed a colon cancer growing on the peritoneal surface in a patient-derived orthotopic xenograft mouse model. Tissue Cell. 2019 Dec; 61:109-114.
Park JH, Han Q, Zhao M, Tan Y, Higuchi T, Yoon SN, Sugisawa N, Yamamoto J, Bouvet M, Clary B, Singh SR, Hoffman RM. PMID: 31759402.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimals
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AMMECR1 Inhibits Apoptosis and Promotes Cell-cycle Progression and Proliferation of the A549 Human Lung Cancer Cell Line. Anticancer Res. 2019 Sep; 39(9):4637-4642.
Ge H, Cheng N, Xu X, Yang Z, Hoffman RM, Zhu J. PMID: 31519561.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Oral Recombinant Methioninase, Combined With Oral Caffeine and Injected Cisplatinum, Overcome Cisplatinum-Resistance and Regresses Patient-derived Orthotopic Xenograft Model of Osteosarcoma. Anticancer Res. 2019 Sep; 39(9):4653-4657.
Higuchi T, Oshiro H, Miyake K, Sugisawa N, Han Q, Tan Y, Park J, Zhang Z, Razmjooei S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Chawla SP, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31519563.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimals
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Oral Recombinant Methioninase Overcomes Colorectal-cancer Liver Metastasis Resistance to the Combination of 5-Fluorouracil and Oxaliplatinum in a Patient-derived Orthotopic Xenograft Mouse Model. Anticancer Res. 2019 Sep; 39(9):4667-4671.
Oshiro H, Tome Y, Kiyuna T, Yoon SN, Lwin TM, Han Q, Tan Y, Miyake K, Higuchi T, Sugisawa N, Katsuya Y, Park JH, Zang Z, Razmjooei S, Bouvet M, Clary B, Singh SR, Kanaya F, Nishida K, Hoffman RM. PMID: 31519565.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansAnimals
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Eribulin Suppressed Cisplatinum- and Doxorubicin-resistant Recurrent Lung Metastatic Osteosarcoma in a Patient-derived Orthotopic Xenograft Mouse Model. Anticancer Res. 2019 Sep; 39(9):4775-4779.
Kiyuna T, Tome Y, Miyake K, Murakami T, Oshiro H, Igarashi K, Kawaguchi K, Hsu J, Singh M, Li Y, Nelson S, Bouvet M, Singh SR, Kanaya F, Hoffman RM. PMID: 31519578.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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Combination Treatment With Sorafenib and Everolimus Regresses a Doxorubicin-resistant Osteosarcoma in a PDOX Mouse Model. Anticancer Res. 2019 Sep; 39(9):4781-4786.
Higuchi T, Sugisawa N, Miyake K, Oshiro H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Kline Z, Belt P, Chawla SP, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31519579.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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Pioglitazone, an agonist of PPARγ, reverses doxorubicin-resistance in an osteosarcoma patient-derived orthotopic xenograft model by downregulating P-glycoprotein expression. Biomed Pharmacother. 2019 Oct; 118:109356.
Higuchi T, Sugisawa N, Miyake K, Oshiro H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Kline Z, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31545293.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Efficacy of oral recombinant methioninase combined with oxaliplatinum and 5-fluorouracil on primary colon cancer in a patient-derived orthotopic xenograft mouse model. Biochem Biophys Res Commun. 2019 10 15; 518(2):306-310.
Park JH, Zhao M, Han Q, Sun Y, Higuchi T, Sugisawa N, Yamamoto J, Singh SR, Clary B, Bouvet M, Hoffman RM. PMID: 31421825.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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High-Mobility Group Box 1 expression predicts survival of patients after resection of adenocarcinoma of the ampulla of Vater. World J Surg Oncol. 2019 Aug 09; 17(1):140.
Murakami T, Matsuyama R, Ueda M, Mochizuki Y, Homma Y, Kameda K, Yazawa K, Izumisawa Y, Fukushima T, Kamimukai N, Yoshida K, Kamiya N, Hoffman RM, Endo I. PMID: 31399104; PMCID: PMC6689175.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Color-coded Imaging of the Fate of Cancer-cell-derived Exosomes During Pancreatic Cancer Metastases in a Nude-mouse Model. Anticancer Res. 2019 Aug; 39(8):4055-4060.
Satake T, Suetsugu A, Nakamura M, Kunisada T, Saji S, Moriwaki H, Shimizu M, Hoffman RM. PMID: 31366487.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Choline-deficient-diet Decreases Fibroblasts in the Circulating Tumor Cell (CTC) Microenvironment. Anticancer Res. 2019 Aug; 39(8):4061-4064.
Matsuura K, Suetsugu A, Satake T, Nakamura M, Kunisada T, Shimizu M, Hoffman RM. PMID: 31366488.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Tumor-sealing Surgical Orthotopic Implantation of Human Colon Cancer in Nude Mice Induces Clinically-relevant Metastases Without Early Peritoneal Carcinomatosis. Anticancer Res. 2019 Aug; 39(8):4065-4071.
Yoon SN, Park JH, Lwin TM, Miyake K, Singh SR, Hoffman RM, Bouvet M. PMID: 31366489.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Sorafenib and Palbociclib Combination Regresses a Cisplatinum-resistant Osteosarcoma in a PDOX Mouse Model. Anticancer Res. 2019 Aug; 39(8):4079-4084.
Higuchi T, Sugisawa N, Miyake K, Oshiro H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Chawla SP, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31366491.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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The Combination of Olaratumab with Doxorubicin and Cisplatinum Regresses a Chemotherapy-Resistant Osteosarcoma in a Patient-Derived Orthotopic Xenograft Mouse Model. Transl Oncol. 2019 Sep; 12(9):1257-1263.
Higuchi T, Sugisawa N, Miyake K, Oshiro H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31299622; PMCID: PMC6624322.
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PubMed Mentions:
6
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RE: "Intraoperative Near-infrared Imaging Can Identify Neoplasms and Aid in Real-time Margin Assessment During Pancreatic Resection". Ann Surg. 2019 07; 270(1):21-22.
Bouvet M, Lwin TM, Hoffman RM. PMID: 31188174.
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PubMed Mentions: Fields:
Translation:
Humans
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Peritoneal Metastases in a Patient-derived Orthotopic Xenograft (PDOX) Model of Colon Cancer Imaged Non-invasively via Red Fluorescent Protein Labeled Stromal Cells. Anticancer Res. 2019 Jul; 39(7):3463-3467.
Park JH, Zhao M, Oshiro H, Miyake K, Higuchi T, Reynoso J, Razmjooei S, Bouvet M, Clary B, Zhang Z, Sugisawa N, Yamamoto J, Singh SR, Hoffman RM. PMID: 31262870.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Hair-follicle-associated pluripotent stem cells derived from cryopreserved intact human hair follicles sustain multilineage differentiation potential. Sci Rep. 2019 06 27; 9(1):9326.
Obara K, Tohgi N, Mii S, Hamada Y, Arakawa N, Aki R, Singh SR, Hoffman RM, Amoh Y. PMID: 31249324; PMCID: PMC6597789.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Promotion of tumor-associated macrophages infiltration by elevated neddylation pathway via NF-κB-CCL2 signaling in lung cancer. Oncogene. 2019 07; 38(29):5792-5804.
Zhou L, Jiang Y, Liu X, Li L, Yang X, Dong C, Liu X, Lin Y, Li Y, Yu J, He R, Huang S, Liu G, Zhang Y, Jeong LS, Hoffman RM, Jia L. PMID: 31243299.
View in:
PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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Expression of anti-aging type-XVII collagen (COL17A1/BP180) in hair follicle-associated pluripotent (HAP) stem cells during differentiation. Tissue Cell. 2019 Aug; 59:33-38.
Shirai K, Obara K, Tohgi N, Yamazaki A, Aki R, Hamada Y, Arakawa N, Singh SR, Hoffman RM, Amoh Y. PMID: 31383286.
View in:
PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Efficacy of Tumor-Targeting Salmonella typhimurium A1-R against Malignancies in Patient-Derived Orthotopic Xenograft (PDOX) Murine Models. Cells. 2019 06 16; 8(6).
Murakami T, Hiroshima Y, Miyake K, Kiyuna T, Endo I, Zhao M, Hoffman RM. PMID: 31208120; PMCID: PMC6628209.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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The combination of gemcitabine and docetaxel arrests a doxorubicin-resistant dedifferentiated liposarcoma in a patient-derived orthotopic xenograft model. Biomed Pharmacother. 2019 Sep; 117:109093.
Miyake K, Higuchi T, Oshiro H, Zhang Z, Sugisawa N, Park JH, Razmjooei S, Katsuya Y, Barangi M, Li Y, Nelson SD, Murakami T, Homma Y, Hiroshima Y, Matsuyama R, Bouvet M, Chawla SP, Singh SR, Endo I, Hoffman RM. PMID: 31200257.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
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Knockdown of Histone Methyltransferase WHSC1 Induces Apoptosis and Inhibits Cell Proliferation and Tumorigenesis in Salivary Adenoid Cystic Carcinoma. Anticancer Res. 2019 Jun; 39(6):2729-2737.
Liu C, Jiang YH, Zhao ZL, Wu HW, Zhang L, Yang Z, Hoffman RM, Zheng JW. PMID: 31177108.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Improved antibody-guided surgery with a near-infrared dye on a pegylated linker for CEA-positive tumors. J Biomed Opt. 2019 06; 24(6):1-9.
Yazaki P, Lwin T, Minnix M, Li L, Sherman A, Molnar J, Miller A, Frankel P, Chea J, Poku E, Bowles N, Hoffman R, Shively J, Bouvet M. PMID: 31254333; PMCID: PMC6978469.
View in:
PubMed Mentions:
10 Fields:
Translation:
Animals
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Traditional Chinese Medicine (TCM) Astragalus Membranaceus and Curcuma Wenyujin Promote Vascular Normalization in Tumor-derived Endothelial Cells of Human Hepatocellular Carcinoma. Anticancer Res. 2019 Jun; 39(6):2739-2747.
Zang W, Bian H, Huang X, Yin G, Zhang C, Han LI, Hao P, Ding S, Sun YU, Yang Z, Hoffman RM, Tang D. PMID: 31177109.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Cyt-Geist: Current and Future Challenges in Cytometry: Reports of the CYTO 2018 Conference Workshops. Cytometry A. 2019 06; 95(6):598-644.
Czechowska K, Lannigan J, Wang L, Arcidiacono J, Ashhurst TM, Barnard RM, Bauer S, Bispo C, Bonilla DL, Brinkman RR, Cabanski M, Chang HD, Chakrabarti L, Chojnowski G, Cotleur B, Degheidy H, Dela Cruz GV, Eck S, Elliott J, Errington R, Filby A, Gagnon D, Gardner R, Green C, Gregory M, Groves CJ, Hall C, Hammes F, Hedrick M, Hoffman R, Icha J, Ivaska J, Jenner DC, Jones D, Kerckhof FM, Kukat C, Lanham D, Leavesley S, Lee M, Lin-Gibson S, Litwin V, Liu Y, Molloy J, Moore JS, Müller S, Nedbal J, Niesner R, Nitta N, Ohlsson-Wilhelm B, Paul NE, Perfetto S, Portat Z, Props R, Radtke S, Rayanki R, Rieger A, Rogers S, Rubbens P, Salomon R, Schiemann M, Sharpe J, Sonder SU, Stewart JJ, Sun Y, Ulrich H, Van Isterdael G, Vitaliti A, van Vreden C, Weber M, Zimmermann J, Vacca G, Wallace P, Tárnok A. PMID: 31207046.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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Targeting neddylation inhibits intravascular survival and extravasation of cancer cells to prevent lung-cancer metastasis. Cell Biol Toxicol. 2019 06; 35(3):233-245.
Jiang Y, Liang Y, Li L, Zhou L, Cheng W, Yang X, Yang X, Qi H, Yu J, Jeong LS, Hoffman RM, Zheng P, Jia L. PMID: 31140025.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Anti-Claudin-1 Conjugated to a Near-Infrared Fluorophore Targets Colon Cancer in PDOX Mouse Models. J Surg Res. 2019 10; 242:145-150.
Hollandsworth HM, Lwin TM, Amirfakhri S, Filemoni F, Batra SK, Hoffman RM, Dhawan P, Bouvet M. PMID: 31077946; PMCID: PMC7144806.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Pazopanib regresses a doxorubicin-resistant synovial sarcoma in a patient-derived orthotopic xenograft mouse model. Tissue Cell. 2019 Jun; 58:107-111.
Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyake M, Nelson SD, Russell TA, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Higuchi T, Singh SR, Tsuchiya H, Hoffman RM. PMID: 31133237.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review. Cells. 2019 05 02; 8(5).
Kawaguchi K, Han Q, Li S, Tan Y, Igarashi K, Murakami T, Unno M, Hoffman RM. PMID: 31052611; PMCID: PMC6562625.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimals
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Tumor-targeting Salmonella typhimurium A1-R overcomes nab-paclitaxel resistance in a cervical cancer PDOX mouse model. Arch Gynecol Obstet. 2019 06; 299(6):1683-1690.
Miyake K, Murata T, Murakami T, Zhao M, Kiyuna T, Kawaguchi K, Igarashi K, Miyake M, Lwin TM, Hozumi C, Komatsu S, Kikuchi T, Bouvet M, Shimoya K, Singh SR, Endo I, Hoffman RM. PMID: 30953192.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Trabectedin and irinotecan combination regresses a cisplatinum-resistant osteosarcoma in a patient-derived orthotopic xenograft nude-mouse model. Biochem Biophys Res Commun. 2019 May 28; 513(2):326-331.
Higuchi T, Miyake K, Oshiro H, Sugisawa N, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Chawla SP, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 30955860.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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Temozolomide targets and arrests a doxorubicin-resistant follicular dendritic-cell sarcoma patient-derived orthotopic xenograft mouse model. Tissue Cell. 2019 Jun; 58:17-23.
Oshiro H, Tome Y, Kiyuna T, Miyake K, Kawaguchi K, Higuchi T, Miyake M, Zang Z, Razmjooei S, Barangi M, Wangsiricharoen S, Nelson SD, Li Y, Bouvet M, Singh SR, Kanaya F, Hoffman RM. PMID: 31133242.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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Chemo-resistant Gastric Cancer Associated Gene Expression Signature: Bioinformatics Analysis Based on Gene Expression Omnibus. Anticancer Res. 2019 Apr; 39(4):1689-1698.
Liu JB, Jian T, Yue C, Chen D, Chen W, Bao TT, Liu HX, Cao Y, Li WB, Yang Z, Hoffman RM, Yu C. PMID: 30952707.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
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P-Glycoprotein Overexpression Is Associated With Cisplatin Resistance in Human Osteosarcoma. Anticancer Res. 2019 Apr; 39(4):1711-1718.
He C, Sun Z, Hoffman RM, Yang Z, Jiang Y, Wang L, Hao Y. PMID: 30952710.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Surgical and histological boundary of the hepatic hilar plate system: basic study relevant to surgery for hilar cholangiocarcinoma regarding the "true" proximal ductal margin. J Hepatobiliary Pancreat Sci. 2019 May; 26(5):159-168.
Kikuchi Y, Matuyama R, Hiroshima Y, Murakami T, Bouvet M, Morioka D, Hoffman RM, Endo I. PMID: 30825363.
View in:
PubMed Mentions:
1 Fields:
Translation:
Humans
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The combination of olaratumab with gemcitabine and docetaxel arrests a chemotherapy-resistant undifferentiated soft-tissue sarcoma in a patient-derived orthotopic xenograft mouse model. Cancer Chemother Pharmacol. 2019 06; 83(6):1075-1082.
Higuchi T, Miyake K, Sugisawa N, Oshiro H, Zhang Z, Razmjooei S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 30929053.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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Olaratumab combined with doxorubicin and ifosfamide overcomes individual doxorubicin and olaratumab resistance of an undifferentiated soft-tissue sarcoma in a PDOX mouse model. Cancer Lett. 2019 06 01; 451:122-127.
Higuchi T, Miyake K, Sugisawa N, Oshiro H, Zhang Z, Razmjooei S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 30867142.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
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β-Catenin Expression Correlates With Prognosis in Hepatocellular Carcinoma Patients Treated With Transcatheter Arterial Chemoembolization. Anticancer Res. 2019 Mar; 39(3):1129-1134.
Xu X, Gao D, Yuan X, Liu LI, Zhang X, Liang X, Chen S, Ai M, Chen BO, Shi D, Yang Z, Hoffman RM, Xu J. PMID: 30842141.
View in:
PubMed Mentions:
5 Fields:
Translation:
Humans
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A patient-derived orthotopic xenograft (PDOX) nude-mouse model precisely identifies effective and ineffective therapies for recurrent leiomyosarcoma. Pharmacol Res. 2019 04; 142:169-175.
Zhang Z, Hu K, Kiyuna T, Miyake K, Kawaguchi K, Igarashi K, Nelson SD, Li Y, Singh SR, Hoffman RM. PMID: 30807865.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
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Osimertinib Regresses an EGFR-Mutant Cisplatinum- Resistant Lung Adenocarcinoma Growing in the Brain in Nude Mice. Transl Oncol. 2019 Apr; 12(4):640-645.
Higuchi T, Oshiro H, Zhang Z, Miyake K, Sugisawa N, Katsuya Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Zhao M, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. PMID: 30807997; PMCID: PMC6393699.
View in:
PubMed Mentions:
5
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Regorafenib regressed a doxorubicin-resistant Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude mouse model. Cancer Chemother Pharmacol. 2019 05; 83(5):809-815.
Miyake K, Kiyuna T, Kawaguchi K, Higuchi T, Oshiro H, Zhang Z, Wangsiricharoen S, Razmjooei S, Li Y, Nelson SD, Murakami T, Hiroshima Y, Matsuyama R, Bouvet M, Chawla SP, Singh SR, Endo I, Hoffman RM. PMID: 30758647.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Encapsulated on Polyvinylidene Fluoride Membranes (PFM) Promote Functional Recovery from Spinal Cord Injury. Stem Cell Rev Rep. 2019 02; 15(1):59-66.
Obara K, Tohgi N, Shirai K, Mii S, Hamada Y, Arakawa N, Aki R, Singh SR, Hoffman RM, Amoh Y. PMID: 30341634.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Combining Tumor-Selective Bacterial Therapy with Salmonella typhimurium A1-R and Cancer Metabolism Targeting with Oral Recombinant Methioninase Regressed an Ewing's Sarcoma in a Patient-Derived Orthotopic Xenograft Model. Chemotherapy. 2018; 63(5):278-283.
Miyake K, Kiyuna T, Li S, Han Q, Tan Y, Zhao M, Oshiro H, Kawaguchi K, Higuchi T, Zhang Z, Razmjooei S, Barangi M, Wangsiricharoen S, Murakami T, Singh AS, Li Y, Nelson SD, Eilber FC, Bouvet M, Hiroshima Y, Chishima T, Matsuyama R, Singh SR, Endo I, Hoffman RM. PMID: 30673664.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Gemcitabine combined with docetaxel precisely regressed a recurrent leiomyosarcoma peritoneal metastasis in a patient-derived orthotopic xenograft (PDOX) model. Biochem Biophys Res Commun. 2019 02 19; 509(4):1041-1046.
Miyake K, Kiyuna T, Miyake M, Kawaguchi K, Zhang Z, Wangsiricharoen S, Razmjooei S, Oshiro H, Higuchi T, Li Y, Nelson SD, Murakami T, Hiroshima Y, Kumamoto T, Matsuyama R, Bouvet M, Singh SR, Chawla SP, Endo I, Hoffman RM. PMID: 30660363.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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Role of the tumor microenvironment in pancreatic cancer. Ann Gastroenterol Surg. 2019 Mar; 3(2):130-137.
Murakami T, Hiroshima Y, Matsuyama R, Homma Y, Hoffman RM, Endo I. PMID: 30923782; PMCID: PMC6422798.
View in:
PubMed Mentions:
64
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The combination of gemcitabine and nab-paclitaxel as a novel effective treatment strategy for undifferentiated soft-tissue sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model. Biomed Pharmacother. 2019 Mar; 111:835-840.
Higuchi T, Kawaguchi K, Miyake K, Oshiro H, Zhang Z, Razmjooei S, Wangsiricharoen S, Igarashi K, Yamamoto N, Hayashi K, Kimura H, Miwa S, Nelson SD, Dry SM, Li Y, Chawla SP, Eilber FC, Singh SR, Tsuchiya H, Hoffman RM. PMID: 30616082.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
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Altered Methionine Metabolism in Cancer Cells. Methods Mol Biol. 2019; 1866:13-26.
Hoffman RM, Stern PH, Coalson DW, Douglas Wallace C, Erbe RW. PMID: 30725404.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Linkage of Methionine Dependence and Other Features of Malignancy. Methods Mol Biol. 2019; 1866:27-36.
Hoffman RM, Erbe RW. PMID: 30725405.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Tumor-Specific S/G2-Phase Cell Cycle Arrest of Cancer Cells by Methionine Restriction. Methods Mol Biol. 2019; 1866:49-60.
Hoffman RM, Yano S. PMID: 30725407.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Efficacy of Methionine-Restricted Diets on Cancers In Vivo. Methods Mol Biol. 2019; 1866:75-81.
Hoffman RM, Hoshiya Y, Guo W. PMID: 30725409.
View in:
PubMed Mentions:
1 Fields:
Translation:
Animals
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Dietary Methionine Restriction-Based Cancer Chemotherapy in Rodents. Methods Mol Biol. 2019; 1866:83-94.
Hoffman RM, Stern PH. PMID: 30725410.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Clinical Studies of Methionine-Restricted Diets for Cancer Patients. Methods Mol Biol. 2019; 1866:95-105.
Hoffman RM. PMID: 30725411.
View in:
PubMed Mentions:
10 Fields:
Translation:
Humans
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Development of Recombinant Methioninase for Cancer Treatment. Methods Mol Biol. 2019; 1866:107-131.
Hoffman RM, Tan Y, Li S, Han Q, Yagi S, Takakura T, Takimoto A, Inagaki K, Kudou D. PMID: 30725412.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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High Efficacy of Recombinant Methioninase on Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Cancer. Methods Mol Biol. 2019; 1866:149-161.
Hoffman RM, Murakami T, Kawaguchi K, Igarashi K, Tan Y, Li S, Han Q. PMID: 30725414.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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L-[Methyl-11C] Methionine-Positron-Emission Tomography (MET-PET). Methods Mol Biol. 2019; 1866:267-271.
Hoffman RM. PMID: 30725422.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Recombinant Methioninase as a DNA Demethylation Agent. Methods Mol Biol. 2019; 1866:279-284.
Hoffman RM, Machover D. PMID: 30725424.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Afterword: Oral Methioninase-Answer to Cancer and Fountain of Youth? Methods Mol Biol. 2019; 1866:311-322.
Hoffman RM, Han Q, Kawaguchi K, Li S, Tan Y. PMID: 30725426.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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Detection of Metastasis in a Patient-derived Orthotopic Xenograft (PDOX) Model of Undifferentiated Pleomorphic Sarcoma with Red Fluorescent Protein. Anticancer Res. 2019 Jan; 39(1):81-85.
Oshiro H, Kiyuna T, Tome Y, Miyake K, Kawaguchi K, Higuchi T, Miyake M, Zhang Z, Razmjooei S, Barangi M, Wangsiricharoen S, Nelson SD, Li Y, Bouvet M, Singh SR, Kanaya F, Hoffman RM. PMID: 30591443.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimals
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Human Hair Follicle Associated-Pluripotent (hHAP) Stem Cells Differentiate to Cardiac Muscle Cells. Methods Mol Biol. 2019; 1879:385-392.
Hoffman RM. PMID: 29992514.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Methioninase Cell-Cycle Trap Cancer Chemotherapy. Methods Mol Biol. 2019; 1866:133-148.
Hoffman RM, Yano S, Igarashi K. PMID: 30725413.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Total Methionine Restriction Treatment of Cancer. Methods Mol Biol. 2019; 1866:163-171.
Hoffman RM, Kokkinakis DM, Frenkel EP. PMID: 30725415.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Methioninase Gene Therapy. Methods Mol Biol. 2019; 1866:173-197.
Hoffman RM, Miki K, Al-Refaie W, Xu M, Tan Y. PMID: 30725416.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Safety and Toxicity of Recombinant Methioninase and Polyethylene Glycol (PEG) Recombinant Methioninase in Primates. Methods Mol Biol. 2019; 1866:211-229.
Hoffman RM, Yang Z, Tan Y, Han Q, Li S, Yagi S. PMID: 30725418.
View in:
PubMed Mentions:
3 Fields:
Translation:
Animals
-
Pilot Phase I Clinical Trial of Methioninase on High-Stage Cancer Patients: Rapid Depletion of Circulating Methionine. Methods Mol Biol. 2019; 1866:231-242.
Hoffman RM, Tan Y, Li S, Han Q, Zavala J, Zavala J. PMID: 30725419.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCellsCTClinical Trials
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Methionine Restriction and Life-Span Extension. Methods Mol Biol. 2019; 1866:263-266.
Hoffman RM. PMID: 30725421.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Is the Hoffman Effect for Methionine Overuse Analogous to the Warburg Effect for Glucose Overuse in Cancer? Methods Mol Biol. 2019; 1866:273-278.
Hoffman RM. PMID: 30725423.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Fluorescent humanized anti-CEA antibody specifically labels metastatic pancreatic cancer in a patient-derived orthotopic xenograft (PDOX) mouse model. Oncotarget. 2018 Dec 18; 9(99):37333-37342.
Lwin TM, Miyake K, Murakami T, DeLong JC, Amirfakhri S, Filemoni F, Yoon SN, Yazaki PJ, Shivley JE, Datnow B, Clary BM, Hoffman RM, Bouvet M. PMID: 30647873; PMCID: PMC6324662.
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PubMed Mentions:
10 Fields:
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Fluorescent Proteins as Sensors for Cellular Behavior in Mice. Prog Mol Biol Transl Sci. 2018; 160:29-45.
Hoffman RM. PMID: 30470291.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Metabolic targeting with recombinant methioninase combined with palbociclib regresses a doxorubicin-resistant dedifferentiated liposarcoma. Biochem Biophys Res Commun. 2018 12 02; 506(4):912-917.
Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyaki M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Higuchi T, Singh AS, Chmielowski B, Nelson SD, Russell TA, Eckardt MA, Dry SM, Li Y, Singh SR, Chawla SP, Eilber FC, Tsuchiya H, Hoffman RM. PMID: 30392912.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimals
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Hair Follicle-Associated Pluripotent(HAP) Stem Cells. Prog Mol Biol Transl Sci. 2018; 160:23-28.
Hoffman RM, Amoh Y. PMID: 30470290.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Real-Time Determination of the Cell-Cycle Position of Individual Cells within Live Tumors Using FUCCI Cell-Cycle Imaging. Cells. 2018 Oct 14; 7(10).
Yano S, Hoffman RM. PMID: 30322204; PMCID: PMC6210921.
View in:
PubMed Mentions:
10 Fields:
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A combination of irinotecan/cisplatinum and irinotecan/temozolomide or tumor-targeting Salmonella typhimurium A1-R arrest doxorubicin- and temozolomide-resistant myxofibrosarcoma in a PDOX mouse model. Biochem Biophys Res Commun. 2018 11 02; 505(3):733-739.
Kiyuna T, Tome Y, Murakami T, Miyake K, Igarashi K, Kawaguchi K, Oshiro H, Higuchi T, Miyake M, Sugisawa N, Zhang Z, Razmjooei S, Wangsiricharoen S, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Eckardt MA, Singh AS, Chawla S, Kanaya F, Eilber FC, Singh SR, Zhao M, Hoffman RM. PMID: 30292411.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Oral Recombinant Methioninase Combined with Caffeine and Doxorubicin Induced Regression of a Doxorubicin-resistant Synovial Sarcoma in a PDOX Mouse Model. Anticancer Res. 2018 Oct; 38(10):5639-5644.
Higuchi T, Kawaguchi K, Miyake K, Han Q, Tan Y, Oshiro H, Sugisawa N, Zhang Z, Razmjooei S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Chawla SP, Singh AS, Eilber FC, Singh SR, Tsuchiya H, Hoffman RM. PMID: 30275182.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Color-coded Imaging of the Circulating Tumor Cell Microenvironment. Anticancer Res. 2018 Oct; 38(10):5635-5638.
Satake T, Suetsugu A, Nakamura M, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. PMID: 30275181.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Tumor targeting Salmonella typhimurium A1-R in combination with gemcitabine (GEM) regresses partially GEM-resistant pancreatic cancer patient-derived orthotopic xenograft (PDOX) nude mouse models. Cell Cycle. 2018; 17(16):2019-2026.
Kawaguchi K, Miyake K, Zhao M, Kiyuna T, Igarashi K, Miyake M, Higuchi T, Oshiro H, Bouvet M, Unno M, Hoffman RM. PMID: 29963961; PMCID: PMC6224272.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Tumor-targeting Salmonella typhimurium A1-R overcomes partial carboplatinum-resistance of a cancer of unknown primary (CUP). Tissue Cell. 2018 Oct; 54:144-149.
Miyake K, Kiyuna T, Miyake M, Zhao M, Wangsiricharoen S, Kawaguchi K, Zhang Z, Higuchi T, Razmjooei S, Li Y, Nelson SD, Russell T, Singh A, Murakami T, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Singh SR, Chawla SP, Eilber FC, Endo I, Hoffman RM. PMID: 30309504.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Ultrasound Microbubble Delivery Targeting Intraplaque Neovascularization Inhibits Atherosclerotic Plaque in an APOE-deficient Mouse Model. In Vivo. 2018 Sep-Oct; 32(5):1025-1032.
Yuan H, Hu H, Sun J, Shi M, Yu H, Li C, Sun YU, Yang Z, Hoffman RM. PMID: 30150423; PMCID: PMC6199608.
View in:
PubMed Mentions:
7 Fields:
Translation:
Animals
-
Combination therapy of tumor-targeting Salmonella typhimurium A1-R and oral recombinant methioninase regresses a BRAF-V600E-negative melanoma. Biochem Biophys Res Commun. 2018 09 18; 503(4):3086-3092.
Kawaguchi K, Higuchi T, Li S, Han Q, Tan Y, Igarashi K, Zhao M, Miyake K, Kiyuna T, Miyake M, Ohshiro H, Sugisawa N, Zhang Z, Razmjooei S, Wangsiricharoen S, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Eckardt MA, Singh AS, Singh SR, Eilber FC, Unno M, Hoffman RM. PMID: 30166061.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Imaging the interaction of αv integrin-GFP in osteosarcoma cells with RFP-expressing host stromal cells and tumor-scaffold collagen in the primary and metastatic tumor microenvironment. J Cell Biochem. 2019 01; 120(1):283-289.
Tome Y, Kiyuna T, Uehara F, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM. PMID: 30145815.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Patterns of sensitivity to a panel of drugs are highly individualised for undifferentiated/unclassified soft tissue sarcoma (USTS) in patient-derived orthotopic xenograft (PDOX) nude-mouse models. J Drug Target. 2019 02; 27(2):211-216.
Kawaguchi K, Igarashi K, Miyake K, Kiyuna T, Miyake M, Singh AS, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Unno M, Singh SR, Eilber FC, Hoffman RM. PMID: 30024282.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
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Trabectedin arrests a doxorubicin-resistant PDGFRA-activated liposarcoma patient-derived orthotopic xenograft (PDOX) nude mouse model. BMC Cancer. 2018 Aug 20; 18(1):840.
Kiyuna T, Tome Y, Murakami T, Kawaguchi K, Igarashi K, Miyake K, Miyake M, Li Y, Nelson SD, Dry SM, Singh AS, Russell TA, Elliott I, Singh SR, Kanaya F, Eilber FC, Hoffman RM. PMID: 30126369; PMCID: PMC6102848.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
-
White paper on microbial anti-cancer therapy and prevention. J Immunother Cancer. 2018 08 06; 6(1):78.
Forbes NS, Coffin RS, Deng L, Evgin L, Fiering S, Giacalone M, Gravekamp C, Gulley JL, Gunn H, Hoffman RM, Kaur B, Liu K, Lyerly HK, Marciscano AE, Moradian E, Ruppel S, Saltzman DA, Tattersall PJ, Thorne S, Vile RG, Zhang HH, Zhou S, McFadden G. PMID: 30081947; PMCID: PMC6091193.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
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Advantages of patient-derived orthotopic mouse models and genetic reporters for developing fluorescence-guided surgery. J Surg Oncol. 2018 Aug; 118(2):253-264.
Lwin TM, Hoffman RM, Bouvet M. PMID: 30080930; PMCID: PMC6146062.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Intravital microscopy of osteolytic progression and therapy response of cancer lesions in the bone. Sci Transl Med. 2018 08 01; 10(452).
Dondossola E, Alexander S, Holzapfel BM, Filippini S, Starbuck MW, Hoffman RM, Navone N, De-Juan-Pardo EM, Logothetis CJ, Hutmacher DW, Friedl P. PMID: 30068572; PMCID: PMC6326183.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Color-coded Imaging Distinguishes Cancer Cells, Stromal Cells, and Recombinant Cancer-stromal Cells in the Tumor Microenvironment During Metastasis. Anticancer Res. 2018 Aug; 38(8):4417-4423.
Nakamura M, Suetsugu A, Hasegawa K, Satake T, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. PMID: 30061205.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
Analysis of Anticancer Activity and Chemical Sensitization Effects of Dendropanax morbifera and Commersonia bartramia Extracts. Anticancer Res. 2018 Jul; 38(7):3853-3861.
Kim S, Park SG, Song YJ, Park JK, Choi CH, Lee S, Hoffman RM. PMID: 29970505.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Tumor-targeting Salmonella typhimurium A1-R arrests a doxorubicin-resistant PDGFRA-amplified patient-derived orthotopic xenograft mouse model of pleomorphic liposarcoma. J Cell Biochem. 2018 09; 119(9):7827-7833.
Kiyuna T, Tome Y, Murakami T, Zhao M, Miyake K, Igarashi K, Kawaguchi K, Miyake M, Oshiro H, Higuchi T, Li Y, Dry SM, Nelson SD, Russell TA, Eckardt MA, Singh AS, Kanaya F, Eilber FC, Hoffman RM. PMID: 29932244; PMCID: PMC6150816.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Oral recombinant methioninase (o-rMETase) is superior to injectable rMETase and overcomes acquired gemcitabine resistance in pancreatic cancer. Cancer Lett. 2018 09 28; 432:251-259.
Kawaguchi K, Miyake K, Han Q, Li S, Tan Y, Igarashi K, Kiyuna T, Miyake M, Higuchi T, Oshiro H, Zhang Z, Razmjooei S, Wangsiricharoen S, Bouvet M, Singh SR, Unno M, Hoffman RM. PMID: 29928962.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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In silico-designed mutations increase variable new-antigen receptor single-domain antibodies for VEGF165 neutralization. Oncotarget. 2018 Jun 15; 9(46):28016-28029.
Millán-Gómez D, Dueñas S, Muñoz PLA, Camacho-Villegas T, Elosua C, Cabanillas-Bernal O, Escalante T, Perona A, Abia D, Drescher F, Fournier PGJ, Ramos MA, Mares RE, Paniagua-Solis J, Mata-Gonzalez T, Gonzalez-Canudas J, Hoffman RM, Licea-Navarro A, Sánchez-Campos N. PMID: 29963259; PMCID: PMC6021326.
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PubMed Mentions:
2 Fields:
-
Erratum: Publisher Correction: Is DNA methylation the new guardian of the genome? Mol Cytogenet. 2018; 11:38.
Hoffman RM. PMID: 29946362; PMCID: PMC6001167.
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PubMed Mentions:
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Tumor-targeting Salmonella typhimurium A1-R suppressed an imatinib-resistant gastrointestinal stromal tumor with c-kit exon 11 and 17 mutations. Heliyon. 2018 Jun; 4(6):e00643.
Miyake K, Kawaguchi K, Miyake M, Zhao M, Kiyuna T, Igarashi K, Zhang Z, Murakami T, Li Y, Nelson SD, Bouvet M, Elliott I, Russell TA, Singh AS, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Singh SR, Endo I, Eilber FC, Hoffman RM. PMID: 30003151; PMCID: PMC6040627.
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PubMed Mentions:
5
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Moesin Up-regulation Is Associated with Enhanced Tumor Progression Imaged Non-invasively in an Orthotopic Mouse Model of Human Glioblastoma. Anticancer Res. 2018 Jun; 38(6):3267-3272.
Wang Q, Lu X, Wang J, Yang Z, Hoffman RM, Wu X. PMID: 29848673.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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The development of fluorescence guided surgery for pancreatic cancer: from bench to clinic. Expert Rev Anticancer Ther. 2018 07; 18(7):651-662.
Lwin TM, Hoffman RM, Bouvet M. PMID: 29768067; PMCID: PMC6298876.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansAnimals
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Doxorubicin-resistant pleomorphic liposarcoma with PDGFRA gene amplification is targeted and regressed by pazopanib in a patient-derived orthotopic xenograft mouse model. Tissue Cell. 2018 Aug; 53:30-36.
Kiyuna T, Murakami T, Tome Y, Igarashi K, Kawaguchi K, Miyake K, Miyake M, Li Y, Nelson SD, Dry SM, Singh AS, Russell TA, Singh SR, Kanaya F, Eilber FC, Hoffman RM. PMID: 30060824.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimals
-
Targeting altered cancer methionine metabolism with recombinant methioninase (rMETase) overcomes partial gemcitabine-resistance and regresses a patient-derived orthotopic xenograft (PDOX) nude mouse model of pancreatic cancer. Cell Cycle. 2018; 17(7):868-873.
Kawaguchi K, Miyake K, Han Q, Li S, Tan Y, Igarashi K, Lwin TM, Higuchi T, Kiyuna T, Miyake M, Oshiro H, Bouvet M, Unno M, Hoffman RM. PMID: 29623758; PMCID: PMC6056209.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
-
Temozolomide regresses a doxorubicin-resistant undifferentiated spindle-cell sarcoma patient-derived orthotopic xenograft (PDOX): precision-oncology nude-mouse model matching the patient with effective therapy. J Cell Biochem. 2018 08; 119(8):6598-6603.
Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyake M, Li Y, Nelson SD, Dry SM, Singh AS, Elliott IA, Russell TA, Eckardt MA, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 29737543.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCTClinical Trials
-
MEK inhibitor trametinib in combination with gemcitabine regresses a patient-derived orthotopic xenograft (PDOX) pancreatic cancer nude mouse model. Tissue Cell. 2018 Jun; 52:124-128.
Kawaguchi K, Igarashi K, Miyake K, Lwin TM, Miyake M, Kiyuna T, Hwang HK, Murakami T, Delong JC, Singh SR, Clary B, Bouvet M, Unno M, Hoffman RM. PMID: 29857821.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimals
-
Exploiting methionine restriction for cancer treatment. Biochem Pharmacol. 2018 08; 154:170-173.
Chaturvedi S, Hoffman RM, Bertino JR. PMID: 29733806.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Patient-derived orthotopic xenograft models for cancer of unknown primary precisely distinguish chemotherapy, and tumor-targeting S. typhimurium A1-R is superior to first-line chemotherapy. Signal Transduct Target Ther. 2018; 3:12.
Miyake K, Kiyuna T, Miyake M, Kawaguchi K, Yoon SN, Zhang Z, Igarashi K, Razmjooei S, Wangsiricharoen S, Murakami T, Li Y, Nelson SD, Russell TA, Singh AS, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Singh SR, Endo I, Eilber FC, Hoffman RM. PMID: 29713497; PMCID: PMC5923205.
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PubMed Mentions:
2 Fields:
-
Recombinant methioninase combined with doxorubicin (DOX) regresses a DOX-resistant synovial sarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model. Oncotarget. 2018 Apr 10; 9(27):19263-19272.
Igarashi K, Kawaguchi K, Li S, Han Q, Tan Y, Gainor E, Kiyuna T, Miyake K, Miyake M, Higuchi T, Oshiro H, Singh AS, Eckardt MA, Nelson SD, Russell TA, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 29721200; PMCID: PMC5922394.
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PubMed Mentions:
9 Fields:
-
Tumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: decoy, trap and kill chemotherapy moves toward the clinic. Cell Cycle. 2018; 17(6):801-809.
Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyake M, Li S, Han Q, Tan Y, Zhao M, Li Y, Nelson SD, Dry SM, Singh AS, Elliott IA, Russell TA, Eckardt MA, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 29374999; PMCID: PMC5969544.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Ethanolic Extract of Traditional Chinese Medicine (TCM) Gamboge Inhibits Colon Cancer via the Wnt/Beta-Catenin Signaling Pathway in an Orthotopic Mouse Model. Anticancer Res. 2018 04; 38(4):1917-1925.
Wang W, Li Y, Chen Y, Chen H, Zhu P, Xu M, Wang H, Wu M, Yang Z, Hoffman RM, Gu Y. PMID: 29599307.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Differential Organ-targeting and Cellular Characteristics of Metastatic Human Pancreatic Cancer Cell Lines in Mouse Models. Anticancer Res. 2018 04; 38(4):1927-1935.
Satake T, Suetsugu A, Nakamura M, Hasegawa K, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. PMID: 29599308.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Visualizing the Tumor Microenvironment by Color-coded Imaging in Orthotopic Mouse Models of Cancer. Anticancer Res. 2018 04; 38(4):1847-1857.
Suetsugu A, Shimizu M, Saji S, Moriwaki H, Hoffman RM. PMID: 29599301.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Individualized doxorubicin sensitivity testing of undifferentiated soft tissue sarcoma (USTS) in a patient-derived orthotopic xenograft (PDOX) model demonstrates large differences between patients. Cell Cycle. 2018; 17(5):627-633.
Kawaguchi K, Igarashi K, Kiyuna T, Miyake K, Miyake M, Murakami T, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Singh AS, Unno M, Eilber FC, Hoffman RM. PMID: 29384032; PMCID: PMC5969558.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Targeting methionine with oral recombinant methioninase (o-rMETase) arrests a patient-derived orthotopic xenograft (PDOX) model of BRAF-V600E mutant melanoma: implications for chronic clinical cancer therapy and prevention. Cell Cycle. 2018; 17(3):356-361.
Kawaguchi K, Han Q, Li S, Tan Y, Igarashi K, Kiyuna T, Miyake K, Miyake M, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Singh AS, Eckardt MA, Unno M, Eilber FC, Hoffman RM. PMID: 29187018; PMCID: PMC5914727.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimals
-
Tumor-targeting Salmonella typhimurium A1-R is a highly effective general therapeutic for undifferentiated soft tissue sarcoma patient-derived orthotopic xenograft nude-mouse models. Biochem Biophys Res Commun. 2018 03 18; 497(4):1055-1061.
Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyake M, Singh AS, Eckardt MA, Nelson SD, Russell TA, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Singh SR, Eilber FC, Hoffman RM. PMID: 29481803.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
-
RT-PCR of peritoneal washings predicts peritoneal pancreatic cancer recurrence. J Surg Res. 2018 06; 226:122-130.
Sato K, Mori R, Hiroshima Y, Oba MS, Matsuyama R, Bouvet M, Hoffman RM, Endo I. PMID: 29661277.
View in:
PubMed Mentions:
2 Fields:
Translation:
Humans
-
Inhibition of growth and metastasis of triple-negative breast cancer targeted by Traditional Chinese Medicine Tubeimu in orthotopic mice models. Chin J Cancer Res. 2018 Feb; 30(1):112-121.
Wang J, Yang X, Han H, Wang L, Bao W, Wang S, Hoffman RM, Yang M, Qi H, An C, Hu K. PMID: 29545725; PMCID: PMC5842225.
View in:
PubMed Mentions:
6
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Fluorescence-guided Surgery with Splenic Preservation Prevents Tumor Recurrence in an Orthotopic Nude-mouse Model of Human Pancreatic Cancer. Anticancer Res. 2018 02; 38(2):665-670.
Hwang HK, Kang CM, Lee SH, Murakami T, Kiyuna T, Kim SH, Hoffman RM, Bouvet M. PMID: 29374688.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
-
Tumor-Specific Labeling of Pancreatic Cancer Using a Humanized Anti-CEA Antibody Conjugated to a Near-Infrared Fluorophore. Ann Surg Oncol. 2018 Apr; 25(4):1079-1085.
Lwin TM, Murakami T, Miyake K, Yazaki PJ, Shivley JE, Hoffman RM, Bouvet M. PMID: 29372363; PMCID: PMC5842124.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Bacterial Therapy of Cancer: Promises, Limitations, and Insights for Future Directions. Front Microbiol. 2018; 9:16.
Kramer MG, Masner M, Ferreira FA, Hoffman RM. PMID: 29472896; PMCID: PMC5810261.
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PubMed Mentions:
43
-
Intra-tumor L-methionine level highly correlates with tumor size in both pancreatic cancer and melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse models. Oncotarget. 2018 Feb 16; 9(13):11119-11125.
Kawaguchi K, Han Q, Li S, Tan Y, Igarashi K, Miyake K, Kiyuna T, Miyake M, Chemielwski B, Nelson SD, Russell TA, Dry SM, Li Y, Singh AS, Eckardt MA, Unno M, Eilber FC, Hoffman RM. PMID: 29541401; PMCID: PMC5834286.
View in:
PubMed Mentions:
15 Fields:
-
Engineered mesenchymal stem-cell-sheets patches prevents postoperative pancreatic leakage in a rat model. Sci Rep. 2018 01 10; 8(1):360.
Kim SR, Yi HJ, Lee YN, Park JY, Hoffman RM, Okano T, Shim IK, Kim SC. PMID: 29321630; PMCID: PMC5762914.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Recombinant methioninase in combination with doxorubicin (DOX) overcomes first-line DOX resistance in a patient-derived orthotopic xenograft nude-mouse model of undifferentiated spindle-cell sarcoma. Cancer Lett. 2018 03 28; 417:168-173.
Igarashi K, Kawaguchi K, Li S, Han Q, Tan Y, Murakami T, Kiyuna T, Miyake K, Miyake M, Singh AS, Eckardt MA, Nelson SD, Russell TA, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Singh SR, Eilber FC, Hoffman RM. PMID: 29306021.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimals
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Growth of doxorubicin-resistant undifferentiated spindle-cell sarcoma PDOX is arrested by metabolic targeting with recombinant methioninase. J Cell Biochem. 2018 04; 119(4):3537-3544.
Igarashi K, Li S, Han Q, Tan Y, Kawaguchi K, Murakami T, Kiyuna T, Miyake K, Li Y, Nelson SD, Dry SM, Singh AS, Elliott IA, Russell TA, Eckardt MA, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 29143983.
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PubMed Mentions:
12 Fields:
Translation:
Animals
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Regorafenib regresses an imatinib-resistant recurrent gastrointestinal stromal tumor (GIST) with a mutation in exons 11 and 17 of c-kit in a patient-derived orthotopic xenograft (PDOX) nude mouse model. Cell Cycle. 2018; 17(6):722-727.
Miyake K, Kawaguchi K, Kiyuna T, Miyake M, Igarashi K, Zhang Z, Murakami T, Li Y, Nelson SD, Elliott I, Russell T, Singh A, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Endo I, Eilber FC, Hoffman RM. PMID: 29334307; PMCID: PMC5969563.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Beating Heart Cells from Hair-Follicle-Associated Pluripotent (HAP) Stem Cells. Methods Mol Biol. 2018; 1842:241-254.
Hoffman RM, Amoh Y. PMID: 30196415.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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3D Sponge-Matrix Histoculture: An Overview. Methods Mol Biol. 2018; 1760:11-17.
Hoffman RM. PMID: 29572789.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
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Clinical Correlation of the Histoculture Drug Response Assay in Gastrointestinal Cancer. Methods Mol Biol. 2018; 1760:61-72.
Hoffman RM. PMID: 29572794.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Clinical Correlation of the Histoculture Drug Response Assay for Head and Neck Cancer. Methods Mol Biol. 2018; 1760:83-92.
Hoffman RM. PMID: 29572796.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Nerve Growth and Interaction in Gelfoam® Histoculture: A Nervous System Organoid. Methods Mol Biol. 2018; 1760:163-186.
Hoffman RM, Mii S, Duong J, Amoh Y. PMID: 29572803.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Imaging DNA Repair After UV Irradiation Damage of Cancer Cells in Gelfoam® Histoculture. Methods Mol Biol. 2018; 1760:199-203.
Miwa S, Hoffman RM. PMID: 29572805.
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PubMed Mentions: Fields:
Translation:
HumansCellsPHPublic Health
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Diagnosis and Pathological Analysis of Patient Cancers by Detection of Proliferating Cells in Gelfoam® Histoculture. Methods Mol Biol. 2018; 1760:49-60.
Hoffman RM. PMID: 29572793.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Imaging the Governing Step of Metastasis in Gelfoam® Histoculture. Methods Mol Biol. 2018; 1760:215-220.
Hoffman RM, Chishima T. PMID: 29572807.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Development of the Histoculture Drug Response Assay (HDRA). Methods Mol Biol. 2018; 1760:39-48.
Hoffman RM, Vescio RA. PMID: 29572792.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Expression and Targeting of Tumor Markers in Gelfoam® Histoculture: Potential Individualized Assays for Immuno-Oncology. Methods Mol Biol. 2018; 1760:29-37.
Hoffman RM, Guadagni F. PMID: 29572791.
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PubMed Mentions: Fields:
Translation:
Humans
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In Vivo-Like Growth Patterns of Multiple Types of Tumors in Gelfoam® Histoculture. Methods Mol Biol. 2018; 1760:19-28.
Hoffman RM, Freeman AE. PMID: 29572790.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Effects of siRNA Silencing of TUG1 and LCAL6 Long Non-coding RNAs on Patient-derived Xenograft of Non-small Cell Lung Cancer. Anticancer Res. 2018 01; 38(1):179-186.
Fang T, Huang H, Li X, Liao J, Yang Z, Hoffman RM, Cheng XI, Liang L, Hu W, Yun S. PMID: 29277771.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
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Traditional Chinese Medicine Curcumin Sensitizes Human Colon Cancer to Radiation by Altering the Expression of DNA Repair-related Genes. Anticancer Res. 2018 01; 38(1):131-136.
Yang G, Qiu J, Wang D, Tao Y, Song Y, Wang H, Tang J, Wang X, Sun YU, Yang Z, Hoffman RM. PMID: 29277765.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Tumor-targeting Salmonella typhimurium A1-R Inhibits Osteosarcoma Angiogenesis in the In Vivo Gelfoam® Assay Visualized by Color-coded Imaging. Anticancer Res. 2018 01; 38(1):159-164.
Kiyuna T, Tome Y, Uehara F, Murakami T, Zhang Y, Zhao M, Kanaya F, Hoffman RM. PMID: 29277768.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Prospective Clinical Correlation of the Histoculture Drug Response Assay for Ovarian Cancer. Methods Mol Biol. 2018; 1760:73-81.
Hoffman RM, Jung PS, Kim MB, Nam JH. PMID: 29572795.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Clinical Usefulness of the Histoculture Drug Response Assay for Breast Cancer. Methods Mol Biol. 2018; 1760:93-100.
Hoffman RM, Tanino H. PMID: 29572797.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Clinical Usefulness of the Histoculture Drug Response Assay for Prostate Cancer and Benign Prostate Hypertrophy (BPH). Methods Mol Biol. 2018; 1760:101-107.
Hoffman RM. PMID: 29572798.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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In Vivo-Like Cell-Cycle Phase Distribution of Cancer Cells in Gelfoam® Histoculture Observed in Real Time by FUCCI Imaging. Methods Mol Biol. 2018; 1760:109-123.
Hoffman RM, Yano S. PMID: 29572799.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Methionine Dependency Determination of Human Patient Tumors in Gelfoam® Histoculture. Methods Mol Biol. 2018; 1760:125-131.
Hoffman RM. PMID: 29572800.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Hair-Shaft Growth in Gelfoam® Histoculture of Skin and Isolated Hair Follicles. Methods Mol Biol. 2018; 1760:133-144.
Hoffman RM, Li L, Cao W. PMID: 29572801.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Hair Follicle-Associated Pluripotent (HAP) Stem Cells in Gelfoam® Histoculture for Use in Spinal Cord Repair. Methods Mol Biol. 2018; 1760:145-162.
Liu F, Hoffman RM. PMID: 29572802.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Comparison of "Dimensionality" of Cancer Cell Culture in Gelfoam® Histoculture and Matrigel. Methods Mol Biol. 2018; 1760:205-214.
Tome Y, Uehara F, Kanaya F, Hoffman RM. PMID: 29572806.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Genetic and metabolic comparison of orthotopic and heterotopic patient-derived pancreatic-cancer xenografts to the original patient tumors. Oncotarget. 2018 Jan 30; 9(8):7867-7881.
Jun E, Hong SM, Yoo HJ, Kim MB, Won JS, An S, Shim IK, Chang S, Hoffman RM, Kim SC. PMID: 29487698; PMCID: PMC5814265.
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PubMed Mentions:
8 Fields:
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Recombinant methioninase (rMETase) is an effective therapeutic for BRAF-V600E-negative as well as -positive melanoma in patient-derived orthotopic xenograft (PDOX) mouse models. Oncotarget. 2018 Jan 02; 9(1):915-923.
Kawaguchi K, Igarashi K, Li S, Han Q, Tan Y, Miyake K, Kiyuna T, Miyake M, Murakami T, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Unno M, Eilber FC, Hoffman RM. PMID: 29416666; PMCID: PMC5787523.
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PubMed Mentions:
19 Fields:
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Temozolomide combined with irinotecan regresses a cisplatinum-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) precision-oncology mouse model. Oncotarget. 2018 Jan 30; 9(8):7774-7781.
Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyake M, Li Y, Nelson SD, Dry SM, Singh AS, Elliott IA, Russell TA, Eckardt MA, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 29487690; PMCID: PMC5814257.
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PubMed Mentions:
6 Fields:
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Near-infrared-conjugated humanized anti-carcinoembryonic antigen antibody targets colon cancer in an orthotopic nude-mouse model. J Surg Res. 2017 10; 218:139-143.
DeLong JC, Murakami T, Yazaki PJ, Hoffman RM, Bouvet M. PMID: 28985840; PMCID: PMC5650098.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Splenectomy is associated with an aggressive tumor growth pattern and altered host immunity in an orthotopic syngeneic murine pancreatic cancer model. Oncotarget. 2017 Oct 24; 8(51):88827-88834.
Hwang HK, Murakami T, Kiyuna T, Kim SH, Lee SH, Kang CM, Hoffman RM, Bouvet M. PMID: 29179479; PMCID: PMC5687649.
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PubMed Mentions:
3 Fields:
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Regarding the applications of fusion-fluorescence imaging using indocyanine green in laparoscopic hepatectomy. Transl Gastroenterol Hepatol. 2017; 2:70.
Lwin TM, Hoffman RM, Bouvet M. PMID: 29034343; PMCID: PMC5638993.
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PubMed Mentions:
3
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Eribulin regresses a doxorubicin-resistant Ewing's sarcoma with a FUS-ERG fusion and CDKN2A-deletion in a patient-derived orthotopic xenograft (PDOX) nude mouse model. J Cell Biochem. 2018 01; 119(1):967-972.
Miyake K, Murakami T, Kiyuna T, Igarashi K, Kawaguchi K, Li Y, Singh AS, Dry SM, Eckardt MA, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Endo I, Eilber FC, Hoffman RM. PMID: 28681998.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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The combination of temozolomide-irinotecan regresses a doxorubicin-resistant patient-derived orthotopic xenograft (PDOX) nude-mouse model of recurrent Ewing's sarcoma with a FUS-ERG fusion and CDKN2A deletion: Direction for third-line patient therapy. Oncotarget. 2017 Nov 28; 8(61):103129-103136.
Miyake K, Murakami T, Kiyuna T, Igarashi K, Kawaguchi K, Miyake M, Li Y, Nelson SD, Dry SM, Bouvet M, Elliott IA, Russell TA, Singh AS, Eckardt MA, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Endo I, Eilber FC, Hoffman RM. PMID: 29262551; PMCID: PMC5732717.
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PubMed Mentions:
17 Fields:
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Implanted hair-follicle-associated pluripotent (HAP) stem cells encapsulated in polyvinylidene fluoride membrane cylinders promote effective recovery of peripheral nerve injury. Cell Cycle. 2017 Oct 18; 16(20):1927-1932.
Yamazaki A, Obara K, Tohgi N, Shirai K, Mii S, Hamada Y, Arakawa N, Aki R, Hoffman RM, Amoh Y. PMID: 28886268; PMCID: PMC5638363.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
-
Hair follicle-associated-pluripotent (HAP) stem cells. Cell Cycle. 2017; 16(22):2169-2175.
Amoh Y, Hoffman RM. PMID: 28749199; PMCID: PMC5736337.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Effective Metabolic Targeting of Human Osteosarcoma Cells In Vitro and in Orthotopic Nude-mouse Models with Recombinant Methioninase. Anticancer Res. 2017 09; 37(9):4807-4812.
Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Murakami T, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Hoffman RM. PMID: 28870899.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Patient-Derived Orthotopic Xenograft (PDOX) Models of Melanoma. Int J Mol Sci. 2017 Aug 31; 18(9).
Hoffman RM. PMID: 28858204; PMCID: PMC5618524.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimals
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Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model. Oncotarget. 2017 Oct 17; 8(49):85516-85525.
Kawaguchi K, Igarashi K, Li S, Han Q, Tan Y, Kiyuna T, Miyake K, Murakami T, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Unno M, Eilber FC, Hoffman RM. PMID: 29156737; PMCID: PMC5689627.
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PubMed Mentions:
32 Fields:
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Tumor-Targeting Salmonella typhimurium A1-R Promotes Tumoricidal CD8+ T Cell Tumor Infiltration and Arrests Growth and Metastasis in a Syngeneic Pancreatic-Cancer Orthotopic Mouse Model. J Cell Biochem. 2018 01; 119(1):634-639.
Murakami T, Hiroshima Y, Zhang Y, Zhao M, Kiyuna T, Hwang HK, Miyake K, Homma Y, Mori R, Matsuyama R, Chishima T, Ichikawa Y, Tanaka K, Bouvet M, Endo I, Hoffman RM. PMID: 28628234.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Clinical Factors That Affect the Establishment of Soft Tissue Sarcoma Patient-Derived Orthotopic Xenografts: A University of California, Los Angeles, Sarcoma Program Prospective Clinical Trial. JCO Precis Oncol. 2017; 2017.
Russell TA, Eckardt MA, Murakami T, Elliott IA, Kawaguchi K, Kiyuna T, Igarashi K, Li Y, Crompton JG, Graham DS, Dry SM, Bernthal N, Yanagawa J, Kalbasi A, Federman N, Chmielowski B, Singh AS, Hoffman RM, Eilber FC. PMID: 30613825; PMCID: PMC6319895.
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PubMed Mentions:
1 Fields:
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Efficacy In Vitro of Caffeine and Valproic Acid on Patient-Derived Undifferentiated Pleomorphic Sarcoma and Rhabdomyosarcoma Cell Lines. Anticancer Res. 2017 08; 37(8):4081-4084.
Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Miwa S, Nelson SD, Dry SM, Li Y, Singh AS, Kimura H, Hayashi K, Yamamoto N, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 28739691.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Chemoprevention by Quercetin of Oral Squamous Cell Carcinoma by Suppression of the NF-κB Signaling Pathway in DMBA-treated Hamsters. Anticancer Res. 2017 08; 37(8):4041-4049.
Zhang W, Yin G, Dai J, Sun YU, Hoffman RM, Yang Z, Fan Y. PMID: 28739686.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Therapeutic Cell-Cycle-Decoy Efficacy of a Telomerase-Dependent Adenovirus in an Orthotopic Model of Chemotherapy-Resistant Human Stomach Carcinomatosis Peritonitis Visualized With FUCCI Imaging. J Cell Biochem. 2017 11; 118(11):3635-3642.
Yano S, Takehara K, Tazawa H, Kishimoto H, Urata Y, Kagawa S, Fujiwara T, Hoffman RM. PMID: 27171483.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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MEK inhibitors cobimetinib and trametinib, regressed a gemcitabine-resistant pancreatic-cancer patient-derived orthotopic xenograft (PDOX). Oncotarget. 2017 Jul 18; 8(29):47490-47496.
Kawaguchi K, Igarashi K, Murakami T, Kiyuna T, Lwin TM, Hwang HK, Delong JC, Clary BM, Bouvet M, Unno M, Hoffman RM. PMID: 28537897; PMCID: PMC5564580.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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A patient-derived orthotopic xenograft (PDOX) mouse model of a cisplatinum-resistant osteosarcoma lung metastasis that was sensitive to temozolomide and trabectedin: implications for precision oncology. Oncotarget. 2017 Sep 22; 8(37):62111-62119.
Igarashi K, Murakami T, Kawaguchi K, Kiyuna T, Miyake K, Zhang Y, Nelson SD, Dry SM, Li Y, Yanagawa J, Russell TA, Singh AS, Tsuchiya H, Elliott I, Eilber FC, Hoffman RM. PMID: 28977930; PMCID: PMC5617490.
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PubMed Mentions:
23 Fields:
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On the role of classical and novel forms of vitamin D in melanoma progression and management. J Steroid Biochem Mol Biol. 2018 03; 177:159-170.
Slominski AT, Brozyna AA, Skobowiat C, Zmijewski MA, Kim TK, Janjetovic Z, Oak AS, Jozwicki W, Jetten AM, Mason RS, Elmets C, Li W, Hoffman RM, Tuckey RC. PMID: 28676457; PMCID: PMC5748362.
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PubMed Mentions:
50 Fields:
Translation:
HumansAnimals
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Choline-Deficient-Diet-Induced Fatty Liver Is a Metastasis-Resistant Microenvironment. Anticancer Res. 2017 07; 37(7):3429-3434.
Nakamura M, Suetsugu A, Hasegawa K, Matsumoto T, Aoki H, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. PMID: 28668831.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Imaging the Role of Multinucleate Pancreatic Cancer Cells and Cancer-Associated Fibroblasts in Peritoneal Metastasis in Mouse Models. Anticancer Res. 2017 07; 37(7):3435-3440.
Hasegawa K, Suetsugu A, Nakamura M, Matsumoto T, Aoki H, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. PMID: 28668832.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Enhancement of Wound Healing by the Traditional Chinese Medicine Herbal Mixture Sophora flavescens in a Rat Model of Perianal Ulceration. In Vivo. 2017 Jul-Aug; 31(4):543-549.
Xu X, Li X, Zhang L, Liu Z, Pan Y, Chen D, Bin D, Deng Q, Sun YU, Hoffman RM, Yang Z, Yuan H. PMID: 28652418; PMCID: PMC5566901.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
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Pancreatic cancer-derived exosomes promote tumor metastasis and liver pre-metastatic niche formation. Oncotarget. 2017 Sep 08; 8(38):63461-63483.
Yu Z, Zhao S, Ren L, Wang L, Chen Z, Hoffman RM, Zhou J. PMID: 28969005; PMCID: PMC5609937.
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PubMed Mentions:
58 Fields:
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A novel anionic-phosphate-platinum complex effectively targets an undifferentiated pleomorphic sarcoma better than cisplatinum and doxorubicin in a patient-derived orthotopic xenograft (PDOX). Oncotarget. 2017 Sep 08; 8(38):63353-63359.
Igarashi K, Kawaguchi K, Murakami T, Kiyuna T, Miyake K, Yamamoto N, Hayashi K, Kimura H, Nelson SD, Dry SM, Li Y, Singh AS, Miwa S, Odani A, Eilber FC, Tsuchiya H, Hoffman RM. PMID: 28968995; PMCID: PMC5609927.
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PubMed Mentions:
11 Fields:
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Locally-applied 5-fluorouracil-loaded slow-release patch prevents pancreatic cancer growth in an orthotopic mouse model. Oncotarget. 2017 Jun 20; 8(25):40140-40151.
Shim IK, Yi HJ, Yi HG, Lee CM, Lee YN, Choi YJ, Jeong SY, Jun E, Hoffman RM, Cho DW, Kim SC. PMID: 28498800; PMCID: PMC5522260.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Salmonella typhimurium A1-R targeting of a chemotherapy-resistant BRAF-V600E melanoma in a patient-derived orthotopic xenograft (PDOX) model is enhanced in combination with either vemurafenib or temozolomide. Cell Cycle. 2017 Jul 03; 16(13):1288-1294.
Kawaguchi K, Igarashi K, Murakami T, Kiyuna T, Zhao M, Zhang Y, Nelson SD, Russell TA, Dry SM, Singh AS, Chmielowski B, Li Y, Unno M, Eilber FC, Hoffman RM. PMID: 28622068; PMCID: PMC5531627.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Neoadjuvant chemoradiotherapy of pancreatic cancer induces a favorable immunogenic tumor microenvironment associated with increased major histocompatibility complex class I-related chain A/B expression. J Surg Oncol. 2017 Sep; 116(3):416-426.
Murakami T, Homma Y, Matsuyama R, Mori R, Miyake K, Tanaka Y, Den K, Nagashima Y, Nakazawa M, Hiroshima Y, Ueda M, Tanaka K, Hoffman RM, Bouvet M, Endo I. PMID: 28608409.
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Genetic Recombination Between Stromal and Cancer Cells Results in Highly Malignant Cells Identified by Color-Coded Imaging in a Mouse Lymphoma Model. J Cell Biochem. 2017 12; 118(12):4216-4221.
Nakamura M, Suetsugu A, Hasegawa K, Matsumoto T, Aoki H, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. PMID: 28419513.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Recombinant methioninase effectively targets a Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model. Oncotarget. 2017 May 30; 8(22):35630-35638.
Murakami T, Li S, Han Q, Tan Y, Kiyuna T, Igarashi K, Kawaguchi K, Hwang HK, Miyake K, Singh AS, Nelson SD, Dry SM, Li Y, Hiroshima Y, Lwin TM, DeLong JC, Chishima T, Tanaka K, Bouvet M, Endo I, Eilber FC, Hoffman RM. PMID: 28404944; PMCID: PMC5482604.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimals
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Strategies for In Vivo Imaging Using Fluorescent Proteins. J Cell Biochem. 2017 09; 118(9):2571-2580.
Hoffman RM. PMID: 27564860.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Analysis of Stroma Labeling During Multiple Passage of a Sarcoma Imageable Patient-Derived Orthotopic Xenograft (iPDOX) in Red Fluorescent Protein Transgenic Nude Mice. J Cell Biochem. 2017 10; 118(10):3367-3371.
Kiyuna T, Murakami T, Tome Y, Kawaguchi K, Igarashi K, Miyake K, Kanaya F, Singh A, Eilber FC, Hoffman RM. PMID: 28300287; PMCID: PMC5550328.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
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Intra-arterial administration of tumor-targeting Salmonella typhimurium A1-R regresses a cisplatin-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model. Cell Cycle. 2017 Jun 18; 16(12):1164-1170.
Igarashi K, Kawaguchi K, Murakami T, Kiyuna T, Miyake K, Nelson SD, Dry SM, Li Y, Yanagawa J, Russell TA, Singh AS, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 28494180; PMCID: PMC5499917.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Toxicology and efficacy of tumor-targeting Salmonella typhimurium A1-R compared to VNP 20009 in a syngeneic mouse tumor model in immunocompetent mice. Oncotarget. 2017 Aug 15; 8(33):54616-54628.
Zhang Y, Cao W, Toneri M, Zhang N, Kiyuna T, Murakami T, Nelson SD, Dry SM, Li Y, Li S, Wang X, Ma H, Singh AS, Eilber FC, Hoffman RM, Zhao M. PMID: 28903369; PMCID: PMC5589608.
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PubMed Mentions:
9 Fields:
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Moesin Expression Is Associated with Glioblastoma Cell Proliferation and Invasion. Anticancer Res. 2017 05; 37(5):2211-2218.
Wang Q, Lu X, Zhao S, Pang M, Wu X, Wu H, Hoffman RM, Yang Z, Zhang Y. PMID: 28476784.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Color-coded intravital imaging demonstrates a transforming growth factor-β (TGF-β) antagonist selectively targets stromal cells in a human pancreatic-cancer orthotopic mouse model. Cell Cycle. 2017 May 19; 16(10):1008-1014.
Murakami T, Hiroshima Y, Miyake K, Hwang HK, Kiyuna T, DeLong JC, Lwin TM, Matsuyama R, Mori R, Kumamoto T, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM. PMID: 28441080; PMCID: PMC5462077.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Tumor-Targeting Salmonella typhimurium A1-R Sensitizes Melanoma With a BRAF-V600E Mutation to Vemurafenib in a Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model. J Cell Biochem. 2017 08; 118(8):2314-2319.
Kawaguchi K, Igarashi K, Murakami T, Zhao M, Zhang Y, Chmielowski B, Kiyuna T, Nelson SD, Russell TA, Dry SM, Li Y, Unno M, Eilber FC, Hoffman RM. PMID: 28106277.
View in:
PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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High Efficacy of Pazopanib on an Undifferentiated Spindle-Cell Sarcoma Resistant to First-Line Therapy Is Identified With a Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model. J Cell Biochem. 2017 09; 118(9):2739-2743.
Igarashi K, Kawaguchi K, Murakami T, Kiyuna T, Miyake K, Singh AS, Nelson SD, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 28176365.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimals
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Combination of gemcitabine and docetaxel regresses both gastric leiomyosarcoma proliferation and invasion in an imageable patient-derived orthotopic xenograft (iPDOX) model. Cell Cycle. 2017 Jun 03; 16(11):1063-1069.
Kawaguchi K, Igarashi K, Murakami T, Kiyuna T, Nelson SD, Dry SM, Li Y, Russell TA, Singh AS, Chmielowski B, Unno M, Eilber FC, Hoffman RM. PMID: 28426279; PMCID: PMC5499841.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimals
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Is DNA methylation the new guardian of the genome? Mol Cytogenet. 2017; 10:11.
Hoffman RM. PMID: 28396696; PMCID: PMC5381125.
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PubMed Mentions:
15
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Temozolomide combined with irinotecan caused regression in an adult pleomorphic rhabdomyosarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model. Oncotarget. 2017 Sep 29; 8(44):75874-75880.
Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Miwa S, Nelson SD, Dry SM, Li Y, Singh AS, Kimura H, Hayashi K, Yamamoto N, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 29100276; PMCID: PMC5652670.
View in:
PubMed Mentions:
17 Fields:
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High-efficacy targeting of colon-cancer liver metastasis with Salmonella typhimurium A1-R via intra-portal-vein injection in orthotopic nude-mouse models. Oncotarget. 2017 Mar 21; 8(12):19065-19073.
Kawaguchi K, Murakami T, Suetsugu A, Kiyuna T, Igarashi K, Hiroshima Y, Zhao M, Zhang Y, Bouvet M, Clary BM, Unno M, Hoffman RM. PMID: 27683127; PMCID: PMC5386670.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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The wayward methyl group and the cascade to cancer. Cell Cycle. 2017 May 03; 16(9):825-829.
Hoffman RM. PMID: 28318368; PMCID: PMC5444351.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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The irony of highly-effective bacterial therapy of a patient-derived orthotopic xenograft (PDOX) model of Ewing's sarcoma, which was blocked by Ewing himself 80 years ago. Cell Cycle. 2017 Jun 03; 16(11):1046-1052.
Murakami T, Kiyuna T, Kawaguchi K, Igarashi K, Singh AS, Hiroshima Y, Zhang Y, Zhao M, Miyake K, Nelson SD, Dry SM, Li Y, DeLong JC, Lwin TM, Chishima T, Tanaka K, Bouvet M, Endo I, Eilber FC, Hoffman RM. PMID: 28296559; PMCID: PMC5499836.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Antimetastatic Efficacy of the Combination of Caffeine and Valproic Acid on an Orthotopic Human Osteosarcoma Cell Line Model in Nude Mice. Anticancer Res. 2017 03; 37(3):1005-1011.
Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Hoffman RM. PMID: 28314258.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Anti-metastatic Efficacy of Traditional Chinese Medicine (TCM) Ginsenoside Conjugated to a VEFGR-3 Antibody on Human Gastric Cancer in an Orthotopic Mouse Model. Anticancer Res. 2017 03; 37(3):979-986.
Dai X, Liu D, Liu M, Zhang X, Wang W, Jin F, Qian Y, Wang X, Zhao J, Wu Y, Xiong F, Chang NA, Sun YU, Yang Z, Hoffman RM, Liu Y. PMID: 28314255.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Potential of immunotherapy for sarcoma. Cancer. 2017 05 01; 123(9):1488-1489.
Hoffman RM, Singh AS, Eilber FC. PMID: 28241102.
View in:
PubMed Mentions:
4 Fields:
Translation:
Humans
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GFP labeling kinetics of triple-negative human breast cancer by a killer-reporter adenovirus in 3D Gelfoam® histoculture. In Vitro Cell Dev Biol Anim. 2017 Jun; 53(6):479-482.
Yano S, Takehara K, Miwa S, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 28233141.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Synergistic Inhibitory Effect of Traditional Chinese Medicine Astragaloside IV and Curcumin on Tumor Growth and Angiogenesis in an Orthotopic Nude-Mouse Model of Human Hepatocellular Carcinoma. Anticancer Res. 2017 02; 37(2):465-473.
Zhang S, Tang D, Zang W, Yin G, Dai J, Sun YU, Yang Z, Hoffman RM, Guo X. PMID: 28179291.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Tumor-targeting Salmonella typhimurium A1-R regresses an osteosarcoma in a patient-derived xenograft model resistant to a molecular-targeting drug. Oncotarget. 2017 Jan 31; 8(5):8035-8042.
Murakami T, Igarashi K, Kawaguchi K, Kiyuna T, Zhang Y, Zhao M, Hiroshima Y, Nelson SD, Dry SM, Li Y, Yanagawa J, Russell T, Federman N, Singh A, Elliott I, Matsuyama R, Chishima T, Tanaka K, Endo I, Eilber FC, Hoffman RM. PMID: 28030831; PMCID: PMC5352380.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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High-metastatic triple-negative breast-cancer variants selected in vivo become chemoresistant in vitro. In Vitro Cell Dev Biol Anim. 2017 Apr; 53(4):285-287.
Yano S, Takehara K, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 28127701.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
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A novel method for RNA extraction from FFPE samples reveals significant differences in biomarker expression between orthotopic and subcutaneous pancreatic cancer patient-derived xenografts. Oncotarget. 2017 Jan 24; 8(4):5885-5894.
Hoover M, Adamian Y, Brown M, Maawy A, Chang A, Lee J, Gharibi A, Katz MH, Fleming J, Hoffman RM, Bouvet M, Doebler R, Kelber JA. PMID: 27602776; PMCID: PMC5351598.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansAnimals
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Reconstitution of a metastatic-resistant tumor microenvironment with cancer-associated fibroblasts enables metastasis. Cell Cycle. 2017 Mar 19; 16(6):533-535.
Murata T, Mekada E, Hoffman RM. PMID: 28103135; PMCID: PMC5384587.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Eradication of melanoma in vitro and in vivo via targeting with a Killer-Red-containing telomerase-dependent adenovirus. Cell Cycle. 2017 Aug 18; 16(16):1502-1508.
Takehara K, Yano S, Tazawa H, Kishimoto H, Narii N, Mizuguchi H, Urata Y, Kagawa S, Fujiwara T, Hoffman RM. PMID: 28055296; PMCID: PMC5584861.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Cervical Cancer Patient-Derived Orthotopic Xenograft (PDOX) Is Sensitive to Cisplatinum and Resistant to Nab-paclitaxel. Anticancer Res. 2017 01; 37(1):61-65.
Murakami T, Murata T, Kawaguchi K, Kiyuna T, Igarashi K, Hwang HK, Hiroshima Y, Hozumi C, Komatsu S, Kikuchi T, Lwin TM, Delong JC, Miyake K, Zhang Y, Tanaka K, Bouvet M, Endo I, Hoffman RM. PMID: 28011474; PMCID: PMC5831332.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
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Comparison of Tumor Recurrence After Resection of Highly- and Poorly-Metastatic Triple-negative Breast Cancer in Orthotopic Nude-Mouse Models. Anticancer Res. 2017 01; 37(1):57-60.
Yano S, Takehara K, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Fujiwara T, Bouvet M, Hoffman RM. PMID: 28011473.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Tumor-targeting Salmonella typhimurium A1-R combined with temozolomide regresses malignant melanoma with a BRAF-V600E mutation in a patient-derived orthotopic xenograft (PDOX) model. Oncotarget. 2016 Dec 27; 7(52):85929-85936.
Kawaguchi K, Igarashi K, Murakami T, Chmielowski B, Kiyuna T, Zhao M, Zhang Y, Singh A, Unno M, Nelson SD, Russell TA, Dry SM, Li Y, Eilber FC, Hoffman RM. PMID: 27835903; PMCID: PMC5349886.
View in:
PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
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The disintegrin echistatin in combination with doxorubicin targets high-metastatic human osteosarcoma overexpressing ανβ3 integrin in chick embryo and nude mouse models. Oncotarget. 2016 Dec 27; 7(52):87031-87036.
Tome Y, Kimura H, Sugimoto N, Tsuchiya H, Kanaya F, Bouvet M, Hoffman RM. PMID: 27894082; PMCID: PMC5349968.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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Tumor-targeting adenovirus OBP-401 inhibits primary and metastatic tumor growth of triple-negative breast cancer in orthotopic nude-mouse models. Oncotarget. 2016 Dec 20; 7(51):85273-85282.
Yano S, Takehara K, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 27863373; PMCID: PMC5356735.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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BRCAness and Prognosis in Triple-Negative Breast Cancer Patients Treated with Neoadjuvant Chemotherapy. PLoS One. 2016; 11(12):e0165721.
Tanino H, Kosaka Y, Nishimiya H, Tanaka Y, Minatani N, Kikuchi M, Shida A, Waraya M, Katoh H, Enomoto T, Sengoku N, Kajita S, Hoffman RM, Watanabe M. PMID: 27935989; PMCID: PMC5147808.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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In Vivo Selection of Intermediately- and Highly-Malignant Variants of Triple-negative Breast Cancer in Orthotopic Nude Mouse Models. Anticancer Res. 2016 12; 36(12):6273-6277.
Yano S, Takehara K, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 27919946.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Human hair-follicle associated pluripotent (hHAP) stem cells differentiate to cardiac-muscle cells. Cell Cycle. 2017 Jan 02; 16(1):95-99.
Tohgi N, Obara K, Yashiro M, Hamada Y, Arakawa N, Mii S, Aki R, Hoffman RM, Amoh Y. PMID: 27880068; PMCID: PMC5270544.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Efficacy of glycogen synthase kinase-3β targeting against osteosarcoma via activation of β-catenin. Oncotarget. 2016 Nov 22; 7(47):77038-77051.
Shimozaki S, Yamamoto N, Domoto T, Nishida H, Hayashi K, Kimura H, Takeuchi A, Miwa S, Igarashi K, Kato T, Aoki Y, Higuchi T, Hirose M, Hoffman RM, Minamoto T, Tsuchiya H. PMID: 27780915; PMCID: PMC5363568.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Fluorescence-guided surgery of a highly-metastatic variant of human triple-negative breast cancer targeted with a cancer-specific GFP adenovirus prevents recurrence. Oncotarget. 2016 11 15; 7(46):75635-75647.
Yano S, Takehara K, Miwa S, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 27689331; PMCID: PMC5342766.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Patient-derived orthotopic xenograft (PDOX) mouse model of adult rhabdomyosarcoma invades and recurs after resection in contrast to the subcutaneous ectopic model. Cell Cycle. 2017 Jan 02; 16(1):91-94.
Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Miwa S, Nelson SD, Dry SM, Li Y, Singh A, Kimura H, Hayashi K, Yamamoto N, Tsuchiya H, Eilber FC, Hoffman RM. PMID: 27830986; PMCID: PMC5270546.
View in:
PubMed Mentions:
21 Fields:
Translation:
HumansAnimals
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Vemurafenib-resistant BRAF-V600E-mutated melanoma is regressed by MEK-targeting drug trametinib, but not cobimetinib in a patient-derived orthotopic xenograft (PDOX) mouse model. Oncotarget. 2016 Nov 01; 7(44):71737-71743.
Kawaguchi K, Murakami T, Chmielowski B, Igarashi K, Kiyuna T, Unno M, Nelson SD, Russell TA, Dry SM, Li Y, Eilber FC, Hoffman RM. PMID: 27690220; PMCID: PMC5342117.
View in:
PubMed Mentions:
41 Fields:
Translation:
HumansAnimals
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Patient-derived mouse models of cancer need to be orthotopic in order to evaluate targeted anti-metastatic therapy. Oncotarget. 2016 11 01; 7(44):71696-71702.
Hiroshima Y, Maawy A, Zhang Y, Zhang N, Murakami T, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM. PMID: 27765934; PMCID: PMC5342112.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansAnimals
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Comparison of in vitro invasiveness of high- and low-metastatic triple-negative human breast cancer visualized by color-coded imaging. In Vitro Cell Dev Biol Anim. 2017 Feb; 53(2):96-98.
Yano S, Takehara K, Tazawa H, Kishimoto H, Kagawa S, Fujiwara T, Hoffman RM. PMID: 27778228.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Enhanced Metastatic Recurrence Via Lymphatic Trafficking of a High-Metastatic Variant of Human Triple-Negative Breast Cancer After Surgical Resection in Orthotopic Nude Mouse Models. J Cell Biochem. 2017 03; 118(3):559-569.
Yano S, Takehara K, Tazawa H, Kishimoto H, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 27626220.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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Effective fluorescence-guided surgery of liver metastasis using a fluorescent anti-CEA antibody. J Surg Oncol. 2016 Dec; 114(8):951-958.
Hiroshima Y, Lwin TM, Murakami T, Mawy AA, Kuniya T, Chishima T, Endo I, Clary BM, Hoffman RM, Bouvet M. PMID: 27696448; PMCID: PMC5565879.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Hypoxia Enhances Differentiation of Hair Follicle-Associated-Pluripotent (HAP) Stem Cells to Cardiac-Muscle Cells. J Cell Biochem. 2017 03; 118(3):554-558.
Shirai K, Hamada Y, Arakawa N, Yamazaki A, Tohgi N, Aki R, Mii S, Hoffman RM, Amoh Y. PMID: 27627796.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Efficacy of a Cell-Cycle Decoying Killer Adenovirus on 3-D Gelfoam®-Histoculture and Tumor-Sphere Models of Chemo-Resistant Stomach Carcinomatosis Visualized by FUCCI Imaging. PLoS One. 2016; 11(9):e0162991.
Yano S, Takehara K, Tazawa H, Kishimoto H, Urata Y, Kagawa S, Fujiwara T, Hoffman RM. PMID: 27673332; PMCID: PMC5038935.
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PubMed Mentions:
1 Fields:
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Fluorescent Orthotopic Mouse Model of Pancreatic Cancer. J Vis Exp. 2016 09 20; (115).
Moreno JA, Sanchez A, Hoffman RM, Nur S, Lambros MP. PMID: 27685334; PMCID: PMC5092057.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Real-Time GFP Intravital Imaging of the Differences in Cellular and Angiogenic Behavior of Subcutaneous and Orthotopic Nude-Mouse Models of Human PC-3 Prostate Cancer. J Cell Biochem. 2016 11; 117(11):2546-51.
Zhang Y, Toneri M, Ma H, Yang Z, Bouvet M, Goto Y, Seki N, Hoffman RM. PMID: 27012365.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Color-coded Imaging Enables Fluorescence-guided Surgery to Resect the Tumor Along with the Tumor Microenvironment in a Syngeneic Mouse Model of EL-4 Lymphoma. Anticancer Res. 2016 09; 36(9):4443-8.
Hasegawa K, Suetsugu A, Nakamura M, Matsumoto T, Kunisada T, Shimizu M, Saji S, Moriwaki H, Bouvet M, Hoffman RM. PMID: 27630280.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Non-toxic Efficacy of the Combination of Caffeine and Valproic Acid on Human Osteosarcoma Cells In Vitro and in Orthotopic Nude-mouse Models. Anticancer Res. 2016 09; 36(9):4477-82.
Igarashi K, Yamamoto N, Hayashi K, Takeuchi A, Kimura H, Miwa S, Hoffman RM, Tsuchiya H. PMID: 27630284.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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A Mouse Model of Fluorescent Protein-expressing Disseminated Peritoneal Lymphoma for Fluorescence-guided Surgery. Anticancer Res. 2016 09; 36(9):4483-7.
Matsumoto T, Suetsugu A, Hasegawa K, Nakamura M, Shibata Y, Aoki H, Kunisada T, Tsurumi H, Shimizu M, Bouvet M, Hoffman RM. PMID: 27630285.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Cell-cycle-dependent drug-resistant quiescent cancer cells induce tumor angiogenesis after chemotherapy as visualized by real-time FUCCI imaging. Cell Cycle. 2017 Mar 04; 16(5):406-414.
Yano S, Takehara K, Tazawa H, Kishimoto H, Urata Y, Kagawa S, Fujiwara T, Hoffman RM. PMID: 27715464; PMCID: PMC5351920.
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Efficacy of Tumor-Targeting Salmonella A1-R on a Melanoma Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Model. PLoS One. 2016; 11(8):e0160882.
Yamamoto M, Zhao M, Hiroshima Y, Zhang Y, Shurell E, Eilber FC, Bouvet M, Noda M, Hoffman RM. PMID: 27500926; PMCID: PMC4976963.
View in:
PubMed Mentions:
55 Fields:
Translation:
HumansAnimalsCells
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Use of αv Integrin Linked to Green Fluorescent Protein in Osteosarcoma Cells and Confocal Microscopy to Image Molecular Dynamics During Lung Metastasis in Nude Mice. Anticancer Res. 2016 Aug; 36(8):3811-6.
Tome Y, Yano S, Sugimoto N, Mii S, Uehara F, Miwa S, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM. PMID: 27466481.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Color-coded Live Imaging of Heterokaryon Formation and Nuclear Fusion of Hybridizing Cancer Cells. Anticancer Res. 2016 Aug; 36(8):3827-31.
Suetsugu A, Matsumoto T, Hasegawa K, Nakamura M, Kunisada T, Shimizu M, Saji S, Moriwaki H, Bouvet M, Hoffman RM. PMID: 27466484.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Efficacy of the Combination of a PARP Inhibitor and UVC on Cancer Cells as Imaged by Focus Formation by the DNA Repair-related Protein 53BP1 Linked to Green Fluorescent Protein. Anticancer Res. 2016 Aug; 36(8):3821-6.
Tome Y, Uehara F, Miwa S, Yano S, Mii S, Efimova EV, Bouvet M, Kimura H, Tsuchiya H, Kanaya F, Hoffman RM. PMID: 27466483.
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PubMed Mentions: Fields:
Translation:
HumansCells
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In Vivo Isolation of a Highly-aggressive Variant of Triple-negative Human Breast Cancer MDA-MB-231 Using Serial Orthotopic Transplantation. Anticancer Res. 2016 Aug; 36(8):3817-20.
Yano S, Takehara K, Miwa S, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 27466482.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Effective molecular targeting of CDK4/6 and IGF-1R in a rare FUS-ERG fusion CDKN2A-deletion doxorubicin-resistant Ewing's sarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model. Oncotarget. 2016 Jul 26; 7(30):47556-47564.
Murakami T, Singh AS, Kiyuna T, Dry SM, Li Y, James AW, Igarashi K, Kawaguchi K, DeLong JC, Zhang Y, Hiroshima Y, Russell T, Eckardt MA, Yanagawa J, Federman N, Matsuyama R, Chishima T, Tanaka K, Bouvet M, Endo I, Eilber FC, Hoffman RM. PMID: 27286459; PMCID: PMC5216960.
View in:
PubMed Mentions:
50 Fields:
Translation:
HumansAnimals
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Disintegrin targeting of an αvβ3 integrin-over-expressing high-metastatic human osteosarcoma with echistatin inhibits cell proliferation, migration, invasion and adhesion in vitro. Oncotarget. 2016 07 19; 7(29):46315-46320.
Tome Y, Kimura H, Kiyuna T, Sugimoto N, Tsuchiya H, Kanaya F, Bouvet M, Hoffman RM. PMID: 27331872; PMCID: PMC5216800.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Early-age-dependent selective decrease of differentiation potential of hair-follicle-associated pluripotent (HAP) stem cells to beating cardiac-muscle cells. Cell Cycle. 2016 Oct; 15(19):2619-2625.
Yamazaki A, Hamada Y, Arakawa N, Yashiro M, Mii S, Aki R, Kawahara K, Hoffman RM, Amoh Y. PMID: 27428074; PMCID: PMC5053548.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Labeling the Stroma of a Patient-Derived Orthotopic Xenograft (PDOX) Mouse Model of Undifferentiated Pleomorphic Soft-Tissue Sarcoma With Red Fluorescent Protein for Rapid Non-Invasive Imaging for Drug Screening. J Cell Biochem. 2017 02; 118(2):361-365.
Kiyuna T, Murakami T, Tome Y, Igarashi K, Kawaguchi K, Russell T, Eckardt MA, Crompton J, Singh A, Bernthal N, Bukata S, Federman N, Kanaya F, Eilber FC, Hoffman RM. PMID: 27357060.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansAnimals
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Use of αv Integrin Linked to GFP to Image Molecular Dynamics in Trafficking Cancer-Cell Emboli. J Cell Biochem. 2017 01; 118(1):26-30.
Tome Y, Yano S, Sugimoto N, Mii S, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM. PMID: 27191371.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Solid tumors provide niche-specific conditions that lead to preferential growth of Salmonella. Oncotarget. 2016 Jun 07; 7(23):35169-80.
Silva-Valenzuela CA, Desai PT, Molina-Quiroz RC, Pezoa D, Zhang Y, Porwollik S, Zhao M, Hoffman RM, Contreras I, Santiviago CA, McClelland M. PMID: 27145267; PMCID: PMC5085218.
View in:
PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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siRNA Targeting of MDR1 Reverses Multidrug Resistance in a Nude Mouse Model of Doxorubicin-resistant Human Hepatocellular Carcinoma. Anticancer Res. 2016 Jun; 36(6):2675-82.
Yang H, Ding R, Tong Z, Huang J, Shen L, Sun YU, Liao J, Yang Z, Hoffman RM, Wang C, Meng X. PMID: 27272776.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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High efficacy of tumor-targeting Salmonella typhimurium A1-R on a doxorubicin- and dactolisib-resistant follicular dendritic-cell sarcoma in a patient-derived orthotopic xenograft PDOX nude mouse model. Oncotarget. 2016 May 31; 7(22):33046-54.
Kiyuna T, Murakami T, Tome Y, Kawaguchi K, Igarashi K, Zhang Y, Zhao M, Li Y, Bouvet M, Kanaya F, Singh A, Dry S, Eilber FC, Hoffman RM. PMID: 27105519; PMCID: PMC5078074.
View in:
PubMed Mentions:
50 Fields:
Translation:
HumansAnimalsCells
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Tumor-specific cell-cycle decoy by Salmonella typhimurium A1-R combined with tumor-selective cell-cycle trap by methioninase overcome tumor intrinsic chemoresistance as visualized by FUCCI imaging. Cell Cycle. 2016 07 02; 15(13):1715-23.
Yano S, Takehara K, Zhao M, Tan Y, Han Q, Li S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 27152859; PMCID: PMC4957602.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Orthotopic Implantation of Intact Tumor Tissue Leads to Metastasis of OCUM-2MD3 Human Gastric Cancer in Nude Mice Visualized in Real Time by Intravital Fluorescence Imaging. Anticancer Res. 2016 May; 36(5):2125-30.
Murakami T, Zhang Y, Wang X, Hiroshima Y, Kasashima H, Yashiro M, Hirakawa K, Miwa A, Kiyuna T, Matsuyama R, Tanaka K, Bouvet M, Endo I, Hoffman RM. PMID: 27127113.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Imaging Nuclear-Cytoplasmic Dynamics in Primary and Metastatic Colon Cancer in Nude Mice. Anticancer Res. 2016 May; 36(5):2113-7.
Hasegawa K, Suetsugu A, Nakamura M, Matsumoto T, Aoki H, Kunisada T, Bouvet M, Shimizu M, Hoffman RM. PMID: 27127111.
View in:
PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Therapeutic Efficacy of the Traditional Chinese Medicine Baishaoqiwu on TNBS-induced Colitis is Associated with Down-regulation of the TLR4/MyD88/NF-κB Signaling Pathway. In Vivo. 2016 May-Jun; 30(3):181-6.
Xu X, Zhang L, Liu Z, Pan Y, Chen D, Yang Z, Deng Q, Cao X, Sun YU, Yang Z, Hoffman RM, Yuan H. PMID: 27107073.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Bone Marrow Mesenchymal Stem Cells Reverse Liver Damage in a Carbon Tetrachloride-induced Mouse Model of Chronic Liver Injury. In Vivo. 2016 May-Jun; 30(3):187-93.
Wang M, Zhang X, Xiong XI, Yang Z, Li P, Wang J, Sun YU, Yang Z, Hoffman RM. PMID: 27107074.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Blockage of autophagy pathway enhances Salmonella tumor-targeting. Oncotarget. 2016 Apr 19; 7(16):22873-82.
Liu B, Jiang Y, Dong T, Zhao M, Wu J, Li L, Chu Y, She S, Zhao H, Hoffman RM, Jia L. PMID: 27013582; PMCID: PMC5008408.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Real-Time In Vivo Confocal Fluorescence Imaging of Prostate Cancer Bone-Marrow Micrometastasis Development at the Cellular Level in Nude Mice. J Cell Biochem. 2016 11; 117(11):2533-7.
Miwa S, Toneri M, Igarashi K, Yano S, Kimura H, Hayashi K, Yamamoto N, Tsuchiya H, Hoffman RM. PMID: 26990763.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Adenoviral targeting of malignant melanoma for fluorescence-guided surgery prevents recurrence in orthotopic nude-mouse models. Oncotarget. 2016 Apr 05; 7(14):18558-72.
Yano S, Takehara K, Kishimoto H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 26701857; PMCID: PMC4951309.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Targeting the insulin growth factor-1 receptor with fluorescent antibodies enables high resolution imaging of human pancreatic cancer in orthotopic mouse models. Oncotarget. 2016 Apr 05; 7(14):18262-8.
Park JY, Lee JY, Zhang Y, Hoffman RM, Bouvet M. PMID: 26919100; PMCID: PMC4951286.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Modified Liver Hanging Maneuver for En-bloc Right-sided Hepatectomy Combined with Total Caudate Lobectomy for Colon-Cancer Liver Metastasis and Hepatocellular Carcinoma. Anticancer Res. 2016 Apr; 36(4):1729-35.
Hiroshima Y, Matsuo K, Kawaguchi D, Kikuchi Y, Endo I, Koda K, Togo S, Hoffman RM, Tanaka K. PMID: 27069152.
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PubMed Mentions: Fields:
Translation:
Humans
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Color-Coded Imaging of Syngeneic Orthotopic Malignant Lymphoma Interacting with Host Stromal Cells During Metastasis. Anticancer Res. 2016 Apr; 36(4):1473-8.
Matsumoto T, Suetsugu A, Hasegawa K, Nakamura M, Aoki H, Kunisada T, Tsurumi H, Shimizu M, Hoffman RM. PMID: 27069122.
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Translation:
AnimalsCells
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Neddylation Inhibition Activates the Extrinsic Apoptosis Pathway through ATF4-CHOP-DR5 Axis in Human Esophageal Cancer Cells. Clin Cancer Res. 2016 Aug 15; 22(16):4145-57.
Chen P, Hu T, Liang Y, Li P, Chen X, Zhang J, Ma Y, Hao Q, Wang J, Zhang P, Zhang Y, Zhao H, Yang S, Yu J, Jeong LS, Qi H, Yang M, Hoffman RM, Dong Z, Jia L. PMID: 26983464.
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PubMed Mentions:
58 Fields:
Translation:
HumansAnimalsCells
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Tumor-targeting Salmonella typhimurium A1-R in combination with doxorubicin eradicate soft tissue sarcoma in a patient-derived orthotopic xenograft (PDOX) model. Oncotarget. 2016 Mar 15; 7(11):12783-90.
Murakami T, DeLong J, Eilber FC, Zhao M, Zhang Y, Zhang N, Singh A, Russell T, Deng S, Reynoso J, Quan C, Hiroshima Y, Matsuyama R, Chishima T, Tanaka K, Bouvet M, Chawla S, Endo I, Hoffman RM. PMID: 26859573; PMCID: PMC4914321.
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PubMed Mentions:
65 Fields:
Translation:
HumansAnimalsCells
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Decreased Expression of Tumor-suppressor Gene LKB1 Correlates with Poor Prognosis in Human Gastric Cancer. Anticancer Res. 2016 Mar; 36(3):869-75.
Sun J, Ling B, Xu X, Ma R, Li G, Cao X, Ling W, Yang Z, Hoffman RM, Lu J. PMID: 26976973.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Use of fluorescent proteins and color-coded imaging to visualize cancer cells with different genetic properties. Cancer Metastasis Rev. 2016 Mar; 35(1):5-19.
Hoffman RM. PMID: 26942457.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Tumor relapse prevented by combining adoptive T cell therapy with Salmonella typhimurium. Oncoimmunology. 2016 Jun; 5(6):e1130207.
Binder DC, Arina A, Wen F, Tu T, Zhao M, Hoffman RM, Wainwright DA, Schreiber H. PMID: 27471609; PMCID: PMC4938310.
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PubMed Mentions:
10 Fields:
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Improved Resection and Outcome of Colon-Cancer Liver Metastasis with Fluorescence-Guided Surgery Using In Situ GFP Labeling with a Telomerase-Dependent Adenovirus in an Orthotopic Mouse Model. PLoS One. 2016; 11(2):e0148760.
Yano S, Takehara K, Miwa S, Kishimoto H, Hiroshima Y, Murakami T, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. PMID: 26849435; PMCID: PMC4743860.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Surgical and Oncological Factors Affecting the Successful Engraftment of Patient-derived Xenografts in Pancreatic Ductal Adenocarcinoma. Anticancer Res. 2016 Feb; 36(2):517-21.
Jun E, Jung J, Jeong SY, Choi EK, Kim MB, Lee JS, Hong SM, Seol HS, Hwang C, Hoffman RM, Shim IK, Chang S, Kim SC. PMID: 26851005.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Fluorescence-guided surgery of human prostate cancer experimental bone metastasis in nude mice using anti-CEA DyLight 650 for tumor illumination. J Orthop Res. 2016 Apr; 34(4):559-65.
Miwa S, De Magalhães N, Toneri M, Zhang Y, Cao W, Bouvet M, Tsuchiya H, Hoffman RM. PMID: 26135883.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Analysis of Two Complementary Single-Gene Deletion Mutant Libraries of Salmonella Typhimurium in Intraperitoneal Infection of BALB/c Mice. Front Microbiol. 2015; 6:1455.
Silva-Valenzuela CA, Molina-Quiroz RC, Desai P, Valenzuela C, Porwollik S, Zhao M, Hoffman RM, Andrews-Polymenis H, Contreras I, Santiviago CA, McClelland M. PMID: 26779130; PMCID: PMC4700939.
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PubMed Mentions:
8
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Fluorescent-Antibody Targeting of Insulin-Like Growth Factor-1 Receptor Visualizes Metastatic Human Colon Cancer in Orthotopic Mouse Models. PLoS One. 2016; 11(1):e0146504.
Park JY, Murakami T, Lee JY, Zhang Y, Hoffman RM, Bouvet M. PMID: 26731105; PMCID: PMC4701661.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Discovery of HAP Stem Cells. Methods Mol Biol. 2016; 1453:15-20.
Li L, Hoffman RM. PMID: 27431242.
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AnimalsCells
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Protocols for Ectopic Hair Growth from Transplanted Whisker Follicles on the Spinal Cord of Mice. Methods Mol Biol. 2016; 1453:137-44.
Cao W, Liu F, Amoh Y, Hoffman RM. PMID: 27431253.
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AnimalsCells
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Cryopreservation of Hair-Follicle Associated Pluripotent (HAP) Stem Cells Maintains Differentiation and Hair-Growth Potential. Adv Exp Med Biol. 2016; 951:191-198.
Hoffman RM, Kajiura S, Cao W, Liu F, Amoh Y. PMID: 27837565.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Tumor-Targeting Salmonella typhimurium A1-R: An Overview. Methods Mol Biol. 2016; 1409:1-8.
Hoffman RM. PMID: 26846797.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Methods for Tumor Targeting with Salmonella typhimurium A1-R. Methods Mol Biol. 2016; 1409:143-64.
Hoffman RM, Zhao M. PMID: 26846809.
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HumansAnimalsCells
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Future of Bacterial Therapy of Cancer. Methods Mol Biol. 2016; 1409:177-84.
Hoffman RM. PMID: 26846811.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Aging hair follicles rejuvenated by transplantation to a young subcutaneous environment. Cell Cycle. 2016; 15(8):1093-8.
Cao W, Li L, Kajiura S, Amoh Y, Tan Y, Liu F, Hoffman RM. PMID: 26940664; PMCID: PMC4889257.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells