Peter Ernst

Title(s)Adjunct Professor, Medicine
SchoolHealth Sciences
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    Collapse Biography 
    Collapse Education and Training
    University of Toronto (Trinity College) BSc1977Gastrointestinal Physiology
    Ontario Veterinary College, Univ of GuelphDVM 1981Veterinary Medicine
    Ontario Veterinary College, Univ of GuelphMSc1981Epidemiology
    McMaster UniversityPodtdoc1985Mucosal Immunology
    McMaster UniversityPhD1986Mucosal Immunology

    Collapse Research 
    Collapse Research Activities and Funding
    UCSD Research Training Program for Veterinarians
    NIH T32OD017863May 2, 2014 - Apr 30, 2024
    Role: Principal Investigator
    Inhibition of Treg function to cure persistent H. pylori infection
    NIH/NIAID R21AI105916Mar 4, 2013 - Feb 28, 2015
    Role: Principal Investigator
    The Role of the Adenosine Receptor in Th Cell Development and Function
    NIH/NIAID R01AI079145Jun 15, 2010 - Nov 30, 2022
    Role: Principal Investigator
    Mechanisms of apoptotic cell clearance in the human stomach
    NIH/NIDDK R01DK084063May 1, 2010 - Apr 30, 2014
    Role: Principal Investigator
    Effects of apoptotic epithelial cell engulfment on mucosal inflammation
    NIH/NIAID R21AI083600Sep 1, 2009 - Sep 30, 2011
    Role: Principal Investigator
    The Role of Adenosine Receptors in Th Cell Development and Function
    NIH/NIAID R56AI079145Sep 30, 2008 - Aug 31, 2010
    Role: Principal Investigator
    Adenosine Receptor Agonists as an Immunotherapy for Biodefense
    NIH/NIAID U01AI070491Aug 15, 2006 - Jul 31, 2013
    Role: Principal Investigator
    The Novel Role for Adenosine Receptor Agonists in Acquired Neonatal Tolerance
    NIH/NIAID R21AI069880Jul 1, 2006 - Jun 30, 2008
    Role: Principal Investigator
    UVA Digestive Health Research Center
    NIH P30DK067629Jun 1, 2004 - May 31, 2010
    Role: Co-Investigator
    Education Program for Digestive Health Research
    NIH/NIDDK R25DK066021Feb 15, 2004 - Jan 31, 2010
    Role: Principal Investigator
    The pathobiology of gastrointestinal disease in mice
    NIH/NCRR K26RR000175Apr 1, 2001 - Mar 31, 2007
    Role: Principal Investigator
    NIH/NIAID T32AI007626Sep 30, 2000 - Jul 31, 2006
    Role: Principal Investigator
    NIH/NIAID R21AI048173Sep 1, 2000 - Aug 31, 2003
    Role: Principal Investigator
    Center for GI Infection and Injury
    NIH P30DK056338Dec 1, 1999 - Feb 28, 2018
    Role: Co-Investigator
    Cytokine Responses to H. pylori Infection, Immunization
    NIH/NIDDK R01DK051677Sep 1, 1997 - May 31, 2009
    Role: Principal Investigator
    NIH/NIDDK R01DK050980Sep 30, 1995 - Aug 31, 2000
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Tokuhara D, Kurashima Y, Kamioka M, Nakayama T, Ernst P, Kiyono H. A comprehensive understanding of the gut mucosal immune system in allergic inflammation. Allergol Int. 2019 Jan; 68(1):17-25. PMID: 30366757.
      View in: PubMed
    2. Tyler CJ, Pérez-Jeldres T, Ehinger E, Capaldo B, Karuppuchamy T, Boyer JD, Patel D, Dulai P, Boland BS, Lannigan J, Eckmann L, Ernst PB, Sandborn WJ, Ho SB, Rivera-Nieves J. Implementation of Mass Cytometry as a Tool for Mechanism of Action Studies in Inflammatory Bowel Disease. Inflamm Bowel Dis. 2018 Oct 12; 24(11):2366-2376. PMID: 29889233.
      View in: PubMed
    3. Garcia-Carbonell R, Wong J, Kim JY, Close LA, Boland BS, Wong TL, Harris PA, Ho SB, Das S, Ernst PB, Sasik R, Sandborn WJ, Bertin J, Gough PJ, Chang JT, Kelliher M, Boone D, Guma M, Karin M. Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death. Proc Natl Acad Sci U S A. 2018 09 25; 115(39):E9192-E9200. PMID: 30209212.
      View in: PubMed
    4. Ernst PB, Carvunis AR. Of mice, men and immunity: a case for evolutionary systems biology. Nat Immunol. 2018 May; 19(5):421-425. PMID: 29670240.
      View in: PubMed
    5. Sarkar A, Tindle C, Pranadinata RF, Reed S, Eckmann L, Stappenbeck TS, Ernst PB, Das S. ELMO1 Regulates Autophagy Induction and Bacterial Clearance During Enteric Infection. J Infect Dis. 2017 Dec 19; 216(12):1655-1666. PMID: 29029244.
      View in: PubMed
    6. Kurashima Y, Yamamoto D, Nelson S, Uematsu S, Ernst PB, Nakayama T, Kiyono H. Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System. Front Immunol. 2017; 8:1787. PMID: 29321781.
      View in: PubMed
    7. Ernst PB. Our New President- Sheila E. Crowe, MD. Gastroenterology. 2017 05; 152(6):1599-1604. PMID: 28363641.
      View in: PubMed
    8. Butcher LD, den Hartog G, Ernst PB, Crowe SE. Oxidative Stress Resulting From Helicobacter pylori Infection Contributes to Gastric Carcinogenesis. Cell Mol Gastroenterol Hepatol. 2017 May; 3(3):316-322. PMID: 28462373.
      View in: PubMed
    9. Chu H, Khosravi A, Kusumawardhani IP, Kwon AH, Vasconcelos AC, Cunha LD, Mayer AE, Shen Y, Wu WL, Kambal A, Targan SR, Xavier RJ, Ernst PB, Green DR, McGovern DP, Virgin HW, Mazmanian SK. Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science. 2016 May 27; 352(6289):1116-20. PMID: 27230380.
      View in: PubMed
    10. den Hartog G, Chattopadhyay R, Ablack A, Hall EH, Butcher LD, Bhattacharyya A, Eckmann L, Harris PR, Das S, Ernst PB, Crowe SE. Regulation of Rac1 and Reactive Oxygen Species Production in Response to Infection of Gastrointestinal Epithelia. PLoS Pathog. 2016 Jan; 12(1):e1005382. PMID: 26761793; PMCID: PMC4711900.
    11. Fox S, Ryan KA, Berger AH, Petro K, Das S, Crowe SE, Ernst PB. The role of C1q in recognition of apoptotic epithelial cells and inflammatory cytokine production by phagocytes during Helicobacter pylori infection. J Inflamm (Lond). 2015; 12:51. PMID: 26357509; PMCID: PMC4563842.
    12. Das S, Sarkar A, Choudhury SS, Owen KA, Castillo V, Fox S, Eckmann L, Elliott MR, Casanova JE, Ernst PB. ELMO1 has an essential role in the internalization of Salmonella Typhimurium into enteric macrophages that impacts disease outcome. Cell Mol Gastroenterol Hepatol. 2015 Apr 01; 1(3):311-324. PMID: 26878033.
      View in: PubMed
    13. Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Zou G, Chang JT. Validation of gene expression biomarker analysis for biopsy-based clinical trials in Crohn's disease. Inflamm Bowel Dis. 2015 Feb; 21(2):323-30. PMID: 25545378.
      View in: PubMed
    14. Kurtz CC, Drygiannakis I, Naganuma M, Feldman S, Bekiaris V, Linden J, Ware CF, Ernst PB. Extracellular adenosine regulates colitis through effects on lymphoid and nonlymphoid cells. Am J Physiol Gastrointest Liver Physiol. 2014 Aug 01; 307(3):G338-46. PMID: 24875104; PMCID: PMC4121634.
    15. Chang JT, Sandborn WJ, Ernst PB. Studies in human intestinal tissues: is it time to reemphasize research in human immunology? Gastroenterology. 2014 Jul; 147(1):26-30. PMID: 24877864.
      View in: PubMed
    16. Alam MS, Kuo JL, Ernst PB, Derr-Castillo V, Pereira M, Gaines D, Costales M, Bigley E, Williams K. Ecto-5'-nucleotidase (CD73) regulates host inflammatory responses and exacerbates murine salmonellosis. Sci Rep. 2014 Mar 27; 4:4486. PMID: 24670982; PMCID: PMC3967249.
    17. Das S, Sarkar A, Ryan KA, Fox S, Berger AH, Juncadella IJ, Bimczok D, Smythies LE, Harris PR, Ravichandran KS, Crowe SE, Smith PD, Ernst PB. Brain angiogenesis inhibitor 1 is expressed by gastric phagocytes during infection with Helicobacter pylori and mediates the recognition and engulfment of human apoptotic gastric epithelial cells. FASEB J. 2014 May; 28(5):2214-24. PMID: 24509909; PMCID: PMC3986834.
    18. Bimczok D, Smythies LE, Waites KB, Grams JM, Stahl RD, Mannon PJ, Peter S, Wilcox CM, Harris PR, Das S, Ernst PB, Smith PD. Helicobacter pylori infection inhibits phagocyte clearance of apoptotic gastric epithelial cells. J Immunol. 2013 Jun 15; 190(12):6626-34. PMID: 23686492; PMCID: PMC3725581.
    19. Mauldin JP, Lu M, Das S, Park D, Ernst PB, Ravichandran KS. A link between the cytoplasmic engulfment protein Elmo1 and the Mediator complex subunit Med31. Curr Biol. 2013 Jan 21; 23(2):162-7. PMID: 23273896; PMCID: PMC3556191.
    20. Tlaxca JL, Rychak JJ, Ernst PB, Konkalmatt PR, Shevchenko TI, Pizarro TT, Pizzaro TT, Rivera-Nieves J, Klibanov AL, Lawrence MB. Ultrasound-based molecular imaging and specific gene delivery to mesenteric vasculature by endothelial adhesion molecule targeted microbubbles in a mouse model of Crohn's disease. J Control Release. 2013 Feb 10; 165(3):216-25. PMID: 23142578; PMCID: PMC3711027.
    21. Röpcke S, Holz O, Lauer G, Müller M, Rittinghausen S, Ernst P, Lahu G, Elmlinger M, Krug N, Hohlfeld JM. Repeatability of and relationship between potential COPD biomarkers in bronchoalveolar lavage, bronchial biopsies, serum, and induced sputum. PLoS One. 2012; 7(10):e46207. PMID: 23056262; PMCID: PMC3464239.
    22. Luo Y, Kong Q, Yang J, Mitra A, Golden G, Wanda SY, Roland KL, Jensen RV, Ernst PB, Curtiss R. Comparative genome analysis of the high pathogenicity Salmonella Typhimurium strain UK-1. PLoS One. 2012; 7(7):e40645. PMID: 22792393; PMCID: PMC3391293.
    23. Warren CA, Calabrese GM, Li Y, Pawlowski SW, Figler RA, Rieger J, Ernst PB, Linden J, Guerrant RL. Effects of adenosine A2A receptor activation and alanyl-glutamine in Clostridium difficile toxin-induced ileitis in rabbits and cecitis in mice. BMC Infect Dis. 2012 Jan 20; 12:13. PMID: 22264229; PMCID: PMC3323464.
    24. Ernst PB, Erickson LD, Loo WM, Scott KG, Wiznerowicz EB, Brown CC, Torres-Velez FJ, Alam MS, Black SG, McDuffie M, Feldman SH, Wallace JL, McKnight GW, Padol IT, Hunt RH, Tung KS. Spontaneous autoimmune gastritis and hypochlorhydria are manifest in the ileitis-prone SAMP1/YitFcs mice. Am J Physiol Gastrointest Liver Physiol. 2012 Jan 01; 302(1):G105-15. PMID: 21921286; PMCID: PMC3345967.
    25. DeLyria ES, Nedrud JG, Ernst PB, Alam MS, Redline RW, Ding H, Czinn SJ, Xu J, Blanchard TG. Vaccine-induced immunity against Helicobacter pylori in the absence of IL-17A. Helicobacter. 2011 Jun; 16(3):169-78. PMID: 21585602; PMCID: PMC3107727.
    26. Luo Y, Kong Q, Yang J, Golden G, Wanda SY, Jensen RV, Ernst PB, Curtiss R. Complete genome sequence of the universal killer Salmonella enterica Serovar Typhimurium UK-1 (ATCC 68169). J Bacteriol. 2011 Aug; 193(15):4035-6. PMID: 21622747; PMCID: PMC3147501.
    27. Wilson JM, Kurtz CC, Black SG, Ross WG, Alam MS, Linden J, Ernst PB. The A2B adenosine receptor promotes Th17 differentiation via stimulation of dendritic cell IL-6. J Immunol. 2011 Jun 15; 186(12):6746-52. PMID: 21593380.
      View in: PubMed
    28. Drygiannakis I, Ernst PB, Lowe D, Glomski IJ. Immunological alterations mediated by adenosine during host-microbial interactions. Immunol Res. 2011 May; 50(1):69-77. PMID: 21479929; PMCID: PMC3361322.
    29. Das S, Owen KA, Ly KT, Park D, Black SG, Wilson JM, Sifri CD, Ravichandran KS, Ernst PB, Casanova JE. Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):2136-41. PMID: 21245295.
      View in: PubMed
    30. Ernst PB, Wiznerowicz EB, Feldman SH, Tung KS. Pathogenesis of gastritis in ileitis-prone SAMP1/Yit mice. Keio J Med. 2011; 60(2):65-8. PMID: 21720202.
      View in: PubMed
    31. Bhattacharyya A, Chattopadhyay R, Hall EH, Mebrahtu ST, Ernst PB, Crowe SE. Mechanism of hypoxia-inducible factor 1 alpha-mediated Mcl1 regulation in Helicobacter pylori-infected human gastric epithelium. Am J Physiol Gastrointest Liver Physiol. 2010 Nov; 299(5):G1177-86. PMID: 20829524; PMCID: PMC2993173.
    32. Ernst PB, Garrison JC, Thompson LF. Much ado about adenosine: adenosine synthesis and function in regulatory T cell biology. J Immunol. 2010 Aug 15; 185(4):1993-8. PMID: 20686167; PMCID: PMC3036969.
    33. Bhattacharyya A, Chattopadhyay R, Burnette BR, Cross JV, Mitra S, Ernst PB, Bhakat KK, Crowe SE. Acetylation of apurinic/apyrimidinic endonuclease-1 regulates Helicobacter pylori-mediated gastric epithelial cell apoptosis. Gastroenterology. 2009 Jun; 136(7):2258-69. PMID: 19505426; PMCID: PMC2694750.
    34. O'Hara AM, Bhattacharyya A, Bai J, Mifflin RC, Ernst PB, Mitra S, Crowe SE. Tumor necrosis factor (TNF)-alpha-induced IL-8 expression in gastric epithelial cells: role of reactive oxygen species and AP endonuclease-1/redox factor (Ref)-1. Cytokine. 2009 Jun; 46(3):359-69. PMID: 19376732; PMCID: PMC2846768.
    35. Wilson JM, Ross WG, Agbai ON, Frazier R, Figler RA, Rieger J, Linden J, Ernst PB. The A2B adenosine receptor impairs the maturation and immunogenicity of dendritic cells. J Immunol. 2009 Apr 15; 182(8):4616-23. PMID: 19342636.
      View in: PubMed
    36. Alam MS, Kurtz CC, Rowlett RM, Reuter BK, Wiznerowicz E, Das S, Linden J, Crowe SE, Ernst PB. CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice. J Infect Dis. 2009 Feb 15; 199(4):494-504. PMID: 19281303.
      View in: PubMed
    37. Ho J, Kurtz CC, Naganuma M, Ernst PB, Cominelli F, Rivera-Nieves J. A CD8+/CD103high T cell subset regulates TNF-mediated chronic murine ileitis. J Immunol. 2008 Feb 15; 180(4):2573-80. PMID: 18250468.
      View in: PubMed
    38. Minohara Y, Boyd DK, Hawkins HK, Ernst PB, Patel J, Crowe SE. The effect of the cag pathogenicity island on binding of Helicobacter pylori to gastric epithelial cells and the subsequent induction of apoptosis. Helicobacter. 2007 Dec; 12(6):583-90. PMID: 18001397; PMCID: PMC3036973.
    39. Rowlett RM, Chrestensen CA, Nyce M, Harp MG, Pelo JW, Cominelli F, Ernst PB, Pizarro TT, Sturgill TW, Worthington MT. MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages. Am J Physiol Gastrointest Liver Physiol. 2008 Feb; 294(2):G452-9. PMID: 18032482.
      View in: PubMed
    40. Ding SZ, Minohara Y, Fan XJ, Wang J, Reyes VE, Patel J, Dirden-Kramer B, Boldogh I, Ernst PB, Crowe SE. Helicobacter pylori infection induces oxidative stress and programmed cell death in human gastric epithelial cells. Infect Immun. 2007 Aug; 75(8):4030-9. PMID: 17562777; PMCID: PMC1952011.
    41. Croxen MA, Ernst PB, Hoffman PS. Antisense RNA modulation of alkyl hydroperoxide reductase levels in Helicobacter pylori correlates with organic peroxide toxicity but not infectivity. J Bacteriol. 2007 May; 189(9):3359-68. PMID: 17337572; PMCID: PMC1855876.
    42. O'Hara AM, Bhattacharyya A, Mifflin RC, Smith MF, Ryan KA, Scott KG, Naganuma M, Casola A, Izumi T, Mitra S, Ernst PB, Crowe SE. Interleukin-8 induction by Helicobacter pylori in gastric epithelial cells is dependent on apurinic/apyrimidinic endonuclease-1/redox factor-1. J Immunol. 2006 Dec 01; 177(11):7990-9. PMID: 17114472.
      View in: PubMed
    43. Naganuma M, Wiznerowicz EB, Lappas CM, Linden J, Worthington MT, Ernst PB. Cutting edge: Critical role for A2A adenosine receptors in the T cell-mediated regulation of colitis. J Immunol. 2006 Sep 01; 177(5):2765-9. PMID: 16920910.
      View in: PubMed
    44. Smith MF, Gautam JK, Black SG, Ernst PB. Microbial-induced regulation of syndecan expression: important host defense mechanism or an opportunity for pathogens? ScientificWorldJournal. 2006 Apr 04; 6:442-5. PMID: 16604254.
      View in: PubMed
    45. Olson TS, Reuter BK, Scott KG, Morris MA, Wang XM, Hancock LN, Burcin TL, Cohn SM, Ernst PB, Cominelli F, Meddings JB, Ley K, Pizarro TT. The primary defect in experimental ileitis originates from a nonhematopoietic source. J Exp Med. 2006 Mar 20; 203(3):541-52. PMID: 16505137; PMCID: PMC2118253.
    46. Ernst PB, Peura DA, Crowe SE. The translation of Helicobacter pylori basic research to patient care. Gastroenterology. 2006 Jan; 130(1):188-206; quiz 212-3. PMID: 16401482.
      View in: PubMed
    47. Ernst PB. Understanding immunity to Helicobacter pylori: unraveling the riddle, wrapped in a mystery, inside an enigma. Gastroenterology. 2005 Jul; 129(1):380-3. PMID: 16012971.
      View in: PubMed
    48. Barrera CA, Beswick EJ, Sierra JC, Bland D, Espejo R, Mifflin R, Adegboyega P, Crowe SE, Ernst PB, Reyes VE. Polarized expression of CD74 by gastric epithelial cells. J Histochem Cytochem. 2005 Dec; 53(12):1481-9. PMID: 15923369; PMCID: PMC3957538.
    49. Nurgalieva ZZ, Conner ME, Opekun AR, Zheng CQ, Elliott SN, Ernst PB, Osato M, Estes MK, Graham DY. B-cell and T-cell immune responses to experimental Helicobacter pylori infection in humans. Infect Immun. 2005 May; 73(5):2999-3006. PMID: 15845507; PMCID: PMC1087341.
    50. Ding SZ, O'Hara AM, Denning TL, Dirden-Kramer B, Mifflin RC, Reyes VE, Ryan KA, Elliott SN, Izumi T, Boldogh I, Mitra S, Ernst PB, Crowe SE. Helicobacter pylori and H2O2 increase AP endonuclease-1/redox factor-1 expression in human gastric epithelial cells. Gastroenterology. 2004 Sep; 127(3):845-58. PMID: 15362040.
      View in: PubMed
    51. Olson TS, Bamias G, Naganuma M, Rivera-Nieves J, Burcin TL, Ross W, Morris MA, Pizarro TT, Ernst PB, Cominelli F, Ley K. Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease. J Clin Invest. 2004 Aug; 114(3):389-98. PMID: 15286805; PMCID: PMC484978.
    52. Duck WM, Sobel J, Pruckler JM, Song Q, Swerdlow D, Friedman C, Sulka A, Swaminathan B, Taylor T, Hoekstra M, Griffin P, Smoot D, Peek R, Metz DC, Bloom PB, Goldschmidt S, Parsonnet J, Triadafilopoulos G, Perez-Perez GI, Vakil N, Ernst P, Czinn S, Dunne D, Gold BD. Antimicrobial resistance incidence and risk factors among Helicobacter pylori-infected persons, United States. Emerg Infect Dis. 2004 Jun; 10(6):1088-94. PMID: 15207062; PMCID: PMC3323181.
    53. Wendelbo Ø, Nesthus I, Sjo M, Paulsen K, Ernst P, Bruserud Ø. Functional characterization of T lymphocytes derived from patients with acute myelogenous leukemia and chemotherapy-induced leukopenia. Cancer Immunol Immunother. 2004 Aug; 53(8):740-7. PMID: 15133630.
      View in: PubMed
    54. Ryan KA, Smith MF, Sanders MK, Ernst PB. Reactive oxygen and nitrogen species differentially regulate Toll-like receptor 4-mediated activation of NF-kappa B and interleukin-8 expression. Infect Immun. 2004 Apr; 72(4):2123-30. PMID: 15039334; PMCID: PMC375203.
    55. Haeberle HA, Casola A, Gatalica Z, Petronella S, Dieterich HJ, Ernst PB, Brasier AR, Garofalo RP. IkappaB kinase is a critical regulator of chemokine expression and lung inflammation in respiratory syncytial virus infection. J Virol. 2004 Mar; 78(5):2232-41. PMID: 14963119; PMCID: PMC369265.
    56. Denning TL, Qi H, König R, Scott KG, Naganuma M, Ernst PB. CD4+ Th cells resembling regulatory T cells that inhibit chronic colitis differentiate in the absence of interactions between CD4 and class II MHC. J Immunol. 2003 Sep 01; 171(5):2279-86. PMID: 12928372.
      View in: PubMed
    57. Denning TL, Takaishi H, Crowe SE, Boldogh I, Jevnikar A, Ernst PB. Oxidative stress induces the expression of Fas and Fas ligand and apoptosis in murine intestinal epithelial cells. Free Radic Biol Med. 2002 Dec 15; 33(12):1641-50. PMID: 12488132.
      View in: PubMed
    58. Takata T, El-Omar E, Camorlinga M, Thompson SA, Minohara Y, Ernst PB, Blaser MJ. Helicobacter pylori does not require Lewis X or Lewis Y expression to colonize C3H/HeJ mice. Infect Immun. 2002 Jun; 70(6):3073-9. PMID: 12011000; PMCID: PMC127983.