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Ariel Feldstein

Title(s)Professor, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
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    Hepatocyte-derived extracellular vesicles in alcoholic liver disease
    NIH/NIAAA R01AA028134Jul 1, 2020 - Mar 31, 2025
    Role: Principal Investigator
    Gain of function mutations in inflammasome related genes in human and experimental alcoholic liver disease
    NIH/NIAAA R01AA024206Sep 20, 2017 - Aug 31, 2022
    Role: Principal Investigator
    Gain of function mutations in inflammasome related genes in human and experimental alcoholic liver disease
    NIH/NIAAA U01AA024206Sep 20, 2017 - Aug 31, 2022
    Role: Principal Investigator
    Sterile inflammation and pyroptotic cell death in liver fibrosis
    NIH/NIDDK R01DK113592Mar 1, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Encapsulated RNAs in extracellular vesicles contribute ALD progression
    NIH/NIAAA R21AA023574Sep 5, 2015 - Aug 31, 2017
    Role: Principal Investigator
    Oxidized Metabolites of Linoleic Acid in Alcohol-induced Liver Injury
    NIH/NIAAA U01AA022489Sep 1, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Alcoholic liver disease: Biochemical, cellular and systemic responses to ethanol
    NIH P20AA017837Sep 30, 2009 - Aug 31, 2014
    Role: Co-Investigator
    Caspase Dependent Cell Death in Nonalcoholic Fatty Liver Disease
    NIH/NIDDK R01DK082451Aug 24, 2009 - Jun 30, 2013
    Role: Principal Investigator
    The Lysosomal-Mitochondrial Axis in Nonalcoholic Fatty Liver Disease
    NIH/NIDDK R01DK076852Mar 1, 2007 - Jul 4, 2011
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Low ω-6 to ω-3 PUFA Ratio (n-6:n-3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth. J Nutr. 2020 Sep 01; 150(9):2314-2321. Van Name MA, Savoye M, Chick JM, Galuppo BT, Feldstein AE, Pierpont B, Johnson C, Shabanova V, Ekong U, Valentino PL, Kim G, Caprio S, Santoro N. PMID: 32652034.
      View in: PubMed   Mentions:    Fields:    
    2. Mechanisms of nonalcoholic fatty liver disease and implications for surgery. Langenbecks Arch Surg. 2020 Aug 24. Kaufmann B, Reca A, Wang B, Friess H, Feldstein AE, Hartmann D. PMID: 32833053.
      View in: PubMed   Mentions:    Fields:    
    3. Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis. J Hepatol. 2020 Aug 04. Gaul S, Leszczynska A, Alegre F, Kaufmann B, Johnson CD, Adams LA, Wree A, Damm G, Seehofer D, Calvente CJ, Povero D, Kisseleva T, Eguchi A, McGeough MD, Hoffman HM, Pelegrin P, Laufs U, Feldstein AE. PMID: 32763266.
      View in: PubMed   Mentions:    Fields:    
    4. The Power of Single Cell Analysis for the Study of Liver Pathobiology. Hepatology. 2020 Aug 01. Chu AL, Schilling JD, King KR, Feldstein AE. PMID: 32740968.
      View in: PubMed   Mentions:    Fields:    
    5. Characterization and Proteome of Circulating Extracellular Vesicles as Potential Biomarkers for NASH. Hepatol Commun. 2020 Sep; 4(9):1263-1278. Povero D, Yamashita H, Ren W, Subramanian MG, Myers RP, Eguchi A, Simonetto DA, Goodman ZD, Harrison SA, Sanyal AJ, Bosch J, Feldstein AE. PMID: 32923831.
      View in: PubMed   Mentions:
    6. Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1ß and IL-17 upregulation in alcoholic hepatitis mice. J Mol Med (Berl). 2020 Jul; 98(7):1021-1034. Eguchi A, Yan R, Pan SQ, Wu R, Kim J, Chen Y, Ansong C, Smith RD, Tempaku M, Ohno-Machado L, Takei Y, Feldstein AE, Tsukamoto H. PMID: 32556367.
      View in: PubMed   Mentions:    Fields:    
    7. The NLRP3 Inflammasome in Alcoholic and Nonalcoholic Steatohepatitis. Semin Liver Dis. 2020 Aug; 40(3):298-306. Knorr J, Wree A, Tacke F, Feldstein AE. PMID: 32526788.
      View in: PubMed   Mentions: 1     Fields:    
    8. ASK1 inhibition reduces cell death and hepatic fibrosis in an Nlrp3 mutant liver injury model. JCI Insight. 2020 01 30; 5(2). Schuster-Gaul S, Geisler LJ, McGeough MD, Johnson CD, Zagorska A, Li L, Wree A, Barry V, Mikaelian I, Jih LJ, Papouchado BG, Budas G, Hoffman HM, Feldstein AE. PMID: 31996485.
      View in: PubMed   Mentions: 3     Fields:    
    9. Identification of actin network proteins, talin-1 and filamin-A, in circulating extracellular vesicles as blood biomarkers for human myalgic encephalomyelitis/chronic fatigue syndrome. Brain Behav Immun. 2020 02; 84:106-114. Eguchi A, Fukuda S, Kuratsune H, Nojima J, Nakatomi Y, Watanabe Y, Feldstein AE. PMID: 31759091.
      View in: PubMed   Mentions: 1     Fields:    
    10. Designing Clinical Trials in Pediatric Nonalcoholic Steatohepatitis: Tips for Patient Selection and Appropriate Endpoints. Hepatol Commun. 2019 Dec; 3(12):1563-1570. Alkhouri N, Kohli R, Feldstein AE. PMID: 31832567.
      View in: PubMed   Mentions:
    11. MicroRNA 223 3p Negatively Regulates the NLRP3 Inflammasome in Acute and Chronic Liver Injury. Mol Ther. 2020 02 05; 28(2):653-663. Jimenez Calvente C, Del Pilar H, Tameda M, Johnson CD, Feldstein AE. PMID: 31585800.
      View in: PubMed   Mentions: 5     Fields:    
    12. Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223. J Clin Invest. 2019 07 11; 129(10):4091-4109. Calvente CJ, Tameda M, Johnson CD, Del Pilar H, Lin YC, Adronikou N, De Mollerat Du Jeu X, Llorente C, Boyer J, Feldstein AE. PMID: 31295147.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    13. NAFLD in children: new genes, new diagnostic modalities and new drugs. Nat Rev Gastroenterol Hepatol. 2019 09; 16(9):517-530. Nobili V, Alisi A, Valenti L, Miele L, Feldstein AE, Alkhouri N. PMID: 31278377.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    14. Human induced pluripotent stem cell-derived extracellular vesicles reduce hepatic stellate cell activation and liver fibrosis. JCI Insight. 2019 06 11; 5. Povero D, Pinatel EM, Leszczynska A, Goyal NP, Nishio T, Kim J, Kneiber D, de Araujo Horcel L, Eguchi A, Ordonez PM, Kisseleva T, Feldstein AE. PMID: 31184999.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    15. Novel Drivers of the Inflammatory Response in Liver Injury and Fibrosis. Semin Liver Dis. 2019 07; 39(3):275-282. Wree A, Holtmann TM, Inzaugarat ME, Feldstein AE. PMID: 31100758.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    16. Extracellular vesicles, the liquid biopsy of the future. J Hepatol. 2019 06; 70(6):1292-1294. Eguchi A, Kostallari E, Feldstein AE, Shah VH. PMID: 30982591.
      View in: PubMed   Mentions: 4     Fields:    
    17. NLR Family Pyrin Domain-Containing 3 Inflammasome Activation in Hepatic Stellate Cells Induces Liver Fibrosis in Mice. Hepatology. 2019 02; 69(2):845-859. Inzaugarat ME, Johnson CD, Holtmann TM, McGeough MD, Trautwein C, Papouchado BG, Schwabe R, Hoffman HM, Wree A, Feldstein AE. PMID: 30180270.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    18. Extracellular Vesicles in Liver Diseases: Meeting Report from the International Liver Congress 2018. Hepatol Commun. 2019 Feb; 3(2):305-315. Banales JM, Feldstein AE, Sänger H, Lukacs-Kornek V, Szabo G, Kornek M. PMID: 30766966.
      View in: PubMed   Mentions:
    19. Non-alcoholic fatty liver disease in pediatric type 2 diabetes: Metabolic and histologic characteristics in 38 subjects. Pediatr Diabetes. 2019 02; 20(1):41-47. Newfield RS, Graves CL, Newbury RO, Schwimmer JB, Proudfoot JA, Say DS, Feldstein AE. PMID: 30467936.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. Differential Activation of Hepatic Invariant NKT Cell Subsets Plays a Key Role in Progression of Nonalcoholic Steatohepatitis. J Immunol. 2018 11 15; 201(10):3017-3035. Maricic I, Marrero I, Eguchi A, Nakamura R, Johnson CD, Dasgupta S, Hernandez CD, Nguyen PS, Swafford AD, Knight R, Feldstein AE, Loomba R, Kumar V. PMID: 30322964.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    21. Correction: Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein levels predict the presence of fibrotic nonalcoholic steatohepatitis (NASH) and NASH cirrhosis. PLoS One. 2018; 13(10):e0205541. Alkhouri N, Johnson C, Adams L, Kitajima S, Tsuruno C, Colpitts TL, Hatcho K, Lawitz E, Lopez R, Feldstein AE. PMID: 30286196.
      View in: PubMed   Mentions:    Fields:    
    22. Ethanol and unsaturated dietary fat induce unique patterns of hepatic ω-6 and ω-3 PUFA oxylipins in a mouse model of alcoholic liver disease. PLoS One. 2018; 13(9):e0204119. Warner DR, Liu H, Ghosh Dastidar S, Warner JB, Prodhan MAI, Yin X, Zhang X, Feldstein AE, Gao B, Prough RA, McClain CJ, Kirpich IA. PMID: 30256818.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    23. Complex Network of NKT Cell Subsets Controls Immune Homeostasis in Liver and Gut. Front Immunol. 2018; 9:2082. Marrero I, Maricic I, Feldstein AE, Loomba R, Schnabl B, Rivera-Nieves J, Eckmann L, Kumar V. PMID: 30254647.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    24. Liquid biopsy for liver diseases. Gut. 2018 12; 67(12):2204-2212. Mann J, Reeves HL, Feldstein AE. PMID: 30177542.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    25. Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein levels predict the presence of fibrotic nonalcoholic steatohepatitis (NASH) and NASH cirrhosis. PLoS One. 2018; 13(8):e0202226. Alkhouri N, Johnson C, Adams L, Kitajima S, Tsuruno C, Colpitts TL, Hatcho K, Lawitz E, Lopez R, Feldstein AE. PMID: 30161179.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    26. Effects of diets enriched in linoleic acid and its peroxidation products on brain fatty acids, oxylipins, and aldehydes in mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 10; 1863(10):1206-1213. Ramsden CE, Hennebelle M, Schuster S, Keyes GS, Johnson CD, Kirpich IA, Dahlen JE, Horowitz MS, Zamora D, Feldstein AE, McClain CJ, Muhlhausler BS, Makrides M, Gibson RA, Taha AY. PMID: 30053599.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    27. Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice. J Lipid Res. 2018 09; 59(9):1597-1609. Schuster S, Johnson CD, Hennebelle M, Holtmann T, Taha AY, Kirpich IA, Eguchi A, Ramsden CE, Papouchado BG, McClain CJ, Feldstein AE. PMID: 30084831.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    28. Triggering and resolution of inflammation in NASH. Nat Rev Gastroenterol Hepatol. 2018 06; 15(6):349-364. Schuster S, Cabrera D, Arrese M, Feldstein AE. PMID: 29740166.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    29. Emricasan, a pan-caspase inhibitor, improves survival and portal hypertension in a murine model of common bile-duct ligation. J Mol Med (Berl). 2018 06; 96(6):575-583. Eguchi A, Koyama Y, Wree A, Johnson CD, Nakamura R, Povero D, Kneiber D, Tameda M, Contreras P, Spada A, Feldstein AE. PMID: 29728708.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    30. Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress. Biomolecules. 2018 03 26; 8(2). Kharbanda KK, Ronis MJJ, Shearn CT, Petersen DR, Zakhari S, Warner DR, Feldstein AE, McClain CJ, Kirpich IA. PMID: 29587455.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. Extracellular vesicles in non-alcoholic and alcoholic fatty liver diseases. Liver Res. 2018 Mar; 2(1):30-34. Eguchi A, Feldstein AE. PMID: 30345152.
      View in: PubMed   Mentions:
    32. Transmembrane BAX Inhibitor motif-containing 1, a novel anti-inflammatory approach for nonalcoholic steatohepatitis treatment. Hepatology. 2018 01; 67(1):438-441. Wree A, Inzaugarat ME, Feldstein AE. PMID: 28859227.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    33. NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL-17 and TNF in mice. Hepatology. 2018 02; 67(2):736-749. Wree A, McGeough MD, Inzaugarat ME, Eguchi A, Schuster S, Johnson CD, Peña CA, Geisler LJ, Papouchado BG, Hoffman HM, Feldstein AE. PMID: 28902427.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    34. TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies. J Clin Invest. 2017 12 01; 127(12):4488-4497. McGeough MD, Wree A, Inzaugarat ME, Haimovich A, Johnson CD, Peña CA, Goldbach-Mansky R, Broderick L, Feldstein AE, Hoffman HM. PMID: 29130929.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    35. Dietary Linoleic Acid and Its Oxidized Metabolites Exacerbate Liver Injury Caused by Ethanol via Induction of Hepatic Proinflammatory Response in Mice. Am J Pathol. 2017 Oct; 187(10):2232-2245. Warner DR, Liu H, Miller ME, Ramsden CE, Gao B, Feldstein AE, Schuster S, McClain CJ, Kirpich IA. PMID: 28923202.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    36. Traffic-related air pollution associations with cytokeratin-18, a marker of hepatocellular apoptosis, in an overweight and obese paediatric population. Pediatr Obes. 2018 06; 13(6):342-347. Hsieh S, Leaderer BP, Feldstein AE, Santoro N, McKay LA, Caprio S, McConnell R. PMID: 28730729.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    37. Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis. Sci Rep. 2017 06 14; 7(1):3491. Cabrera D, Wree A, Povero D, Solís N, Hernandez A, Pizarro M, Moshage H, Torres J, Feldstein AE, Cabello-Verrugio C, Brandan E, Barrera F, Arab JP, Arrese M. PMID: 28615649.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    38. Inflammasomes in Liver Fibrosis. Semin Liver Dis. 2017 05; 37(2):119-127. Alegre F, Pelegrin P, Feldstein AE. PMID: 28564720.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    39. Oxidized Derivatives of Linoleic Acid in Pediatric Metabolic Syndrome: Is Their Pathogenic Role Modulated by the Genetic Background and the Gut Microbiota? Antioxid Redox Signal. 2019 01 10; 30(2):241-250. Tricò D, Di Sessa A, Caprio S, Chalasani N, Liu W, Liang T, Graf J, Herzog RI, Johnson CD, Umano GR, Feldstein AE, Santoro N. PMID: 28279074.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    40. NASH-RELATED CIRRHOSIS: AN OCCULT LIVER DISEASE BURDEN. Hepatol Commun. 2017 Apr; 1(2):84-86. Arrese M, Feldstein AE. PMID: 29335681.
      View in: PubMed   Mentions:
    41. NASH: Novel therapeutic strategies targeting ASK1 in NASH. Nat Rev Gastroenterol Hepatol. 2017 06; 14(6):329-330. Schuster S, Feldstein AE. PMID: 28377639.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    42. Treating nonalcoholic steatohepatitis in children: Not a cinch task. Hepatology. 2017 04; 65(4):1407-1409. Alkhouri N, Feldstein AE. PMID: 28073147.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    43. Microvesicles released from fat-laden cells promote activation of hepatocellular NLRP3 inflammasome: A pro-inflammatory link between lipotoxicity and non-alcoholic steatohepatitis. PLoS One. 2017; 12(3):e0172575. Cannito S, Morello E, Bocca C, Foglia B, Benetti E, Novo E, Chiazza F, Rogazzo M, Fantozzi R, Povero D, Sutti S, Bugianesi E, Feldstein AE, Albano E, Collino M, Parola M. PMID: 28249038.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    44. Update on lipid species and paediatric nonalcoholic fatty liver disease. Curr Opin Clin Nutr Metab Care. 2017 03; 20(2):110-116. Mann JP, Feldstein AE, Nobili V. PMID: 27906700.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    45. NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. J Hepatol. 2017 05; 66(5):1037-1046. Mridha AR, Wree A, Robertson AAB, Yeh MM, Johnson CD, Van Rooyen DM, Haczeyni F, Teoh NC, Savard C, Ioannou GN, Masters SL, Schroder K, Cooper MA, Feldstein AE, Farrell GC. PMID: 28167322.
      View in: PubMed   Mentions: 84     Fields:    Translation:Animals
    46. Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood. Hepatology. 2017 02; 65(2):475-490. Eguchi A, Lazaro RG, Wang J, Kim J, Povero D, Willliams B, Ho SB, Stärkel P, Schnabl B, Ohno-Machado L, Tsukamoto H, Feldstein AE. PMID: 27639178.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    47. Fatty liver in adolescents: Mechanisms, clinical features and therapy. J Hepatol. 2016 12; 65(6):1258-1260. Nobili V, Feldstein AE. PMID: 27742132.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    48. Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress. J Mol Med (Berl). 2016 11; 94(11):1241-1253. Eguchi A, Lazic M, Armando AM, Phillips SA, Katebian R, Maraka S, Quehenberger O, Sears DD, Feldstein AE. PMID: 27394413.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    49. Hepatocyte mitochondrial DNA released in microparticles and toll-like receptor 9 activation: A link between lipotoxicity and inflammation during nonalcoholic steatohepatitis. Hepatology. 2016 08; 64(2):669-71. Inzaugarat ME, Wree A, Feldstein AE. PMID: 27239763.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    50. Soluble IgM links apoptosis to complement activation in early alcoholic liver disease in mice. Mol Immunol. 2016 Apr; 72:9-18. Smathers RL, Chiang DJ, McMullen MR, Feldstein AE, Roychowdhury S, Nagy LE. PMID: 26922040.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    51. Targeting Cell Death and Sterile Inflammation Loop for the Treatment of Nonalcoholic Steatohepatitis. Semin Liver Dis. 2016 Feb; 36(1):27-36. Wree A, Mehal WZ, Feldstein AE. PMID: 26870930.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    52. Innate Immunity and Inflammation in NAFLD/NASH. Dig Dis Sci. 2016 May; 61(5):1294-303. Arrese M, Cabrera D, Kalergis AM, Feldstein AE. PMID: 26841783.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    53. Noninvasive diagnosis of nonalcoholic fatty liver disease: Are we there yet? Metabolism. 2016 Aug; 65(8):1087-95. Alkhouri N, Feldstein AE. PMID: 26972222.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    54. Novel Molecular Mechanisms in the Development of Non-Alcoholic Steatohepatitis. Diabetes Metab J. 2016 Feb; 40(1):1-11. Povero D, Feldstein AE. PMID: 26912150.
      View in: PubMed   Mentions:
    55. Similarities and differences between pediatric and adult nonalcoholic fatty liver disease. Metabolism. 2016 Aug; 65(8):1161-71. Crespo M, Lappe S, Feldstein AE, Alkhouri N. PMID: 26961580.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    56. Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study. Hepatology. 2016 Jan; 63(1):117-25. Goffredo M, Caprio S, Feldstein AE, D'Adamo E, Shaw MM, Pierpont B, Savoye M, Zhao H, Bale AE, Santoro N. PMID: 26457389.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    57. Liver Bid suppression for treatment of fibrosis associated with non-alcoholic steatohepatitis. J Hepatol. 2016 Mar; 64(3):699-707. Eguchi A, De Mollerat Du Jeu X, Johnson CD, Nektaria A, Feldstein AE. PMID: 26555271.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    58. Lipid-induced hepatocyte-derived extracellular vesicles regulate hepatic stellate cell via microRNAs targeting PPAR-?. Cell Mol Gastroenterol Hepatol. 2015 Nov 01; 1(6):646-663.e4. Povero D, Panera N, Eguchi A, Johnson CD, Papouchado BG, de Araujo Horcel L, Pinatel EM, Alisi A, Nobili V, Feldstein AE. PMID: 26783552.
      View in: PubMed   Mentions: 37     Fields:    
    59. Etiology, outcome and prognostic factors of childhood acute liver failure in a German Single Center. Ann Hepatol. 2015 Sep-Oct; 14(5):722-8. Kathemann S, Bechmann LP, Sowa JP, Manka P, Dechêne A, Gerner P, Lainka E, Hoyer PF, Feldstein AE, Canbay A. PMID: 26256901.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    60. Burden of nonalcoholic fatty liver disease and advanced fibrosis in a Texas Hispanic community cohort. World J Hepatol. 2015 Jun 18; 7(11):1586-94. Pan JJ, Fisher-Hoch SP, Chen C, Feldstein AE, McCormick JB, Rahbar MH, Beretta L, Fallon MB. PMID: 26085918.
      View in: PubMed   Mentions:
    61. Redox nanoparticles as a novel treatment approach for inflammation and fibrosis associated with nonalcoholic steatohepatitis. Nanomedicine (Lond). 2015; 10(17):2697-708. Eguchi A, Yoshitomi T, Lazic M, Johnson CD, Vong LB, Wree A, Povero D, Papouchado BG, Nagasaki Y, Feldstein AE. PMID: 26020857.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    62. Serum cytokeratin-18 fragment levels predict development of type 2 diabetes mellitus in adult patients with NAFLD. Liver Int. 2015 Dec; 35(12):2621. Nagpal SJ, Lopez R, Feldstein AE, Alkhouri N. PMID: 25939859.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    63. Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation. Cell Death Differ. 2015 Dec; 22(12):1985-94. Wree A, Johnson CD, Font-Burgada J, Eguchi A, Povero D, Karin M, Feldstein AE. PMID: 25909884.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    64. Microparticles release by adipocytes act as "find-me" signals to promote macrophage migration. PLoS One. 2015; 10(4):e0123110. Eguchi A, Mulya A, Lazic M, Radhakrishnan D, Berk MP, Povero D, Gornicka A, Feldstein AE. PMID: 25849214.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    65. Circulating Soluble Fas and Fas Ligand Levels Are Elevated in Children with Nonalcoholic Steatohepatitis. Dig Dis Sci. 2015 Aug; 60(8):2353-9. Alkhouri N, Alisi A, Okwu V, Matloob A, Ferrari F, Crudele A, De Vito R, Lopez R, Feldstein AE, Nobili V. PMID: 25764498.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    66. Beneficial effects of mineralocorticoid receptor blockade in experimental non-alcoholic steatohepatitis. Liver Int. 2015 Sep; 35(9):2129-38. Pizarro M, Solís N, Quintero P, Barrera F, Cabrera D, Rojas-de Santiago P, Arab JP, Padilla O, Roa JC, Moshage H, Wree A, Inzaugarat E, Feldstein AE, Fardella CE, Baudrand R, Riquelme A, Arrese M. PMID: 25646700.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    67. Endoscopic treatment of pediatric post-transplant biliary complications is safe and effective. Dig Endosc. 2015 May; 27(4):505-511. Dechêne A, Kodde C, Kathemann S, Treckmann J, Lainka E, Paul A, Gerken G, Feldstein AE, Hoyer PF, Canbay A. PMID: 25545826.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    68. Circulating microRNAs: emerging biomarkers of liver disease. Semin Liver Dis. 2015 Feb; 35(1):43-54. Arrese M, Eguchi A, Feldstein AE. PMID: 25632934.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    69. The evaluation of hepatic fibrosis scores in children with nonalcoholic fatty liver disease. Dig Dis Sci. 2015 May; 60(5):1440-7. Mansoor S, Yerian L, Kohli R, Xanthakos S, Angulo P, Ling S, Lopez R, Christine CK, Feldstein AE, Alkhouri N. PMID: 25540086.
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    70. Circulating extracellular vesicles with specific proteome and liver microRNAs are potential biomarkers for liver injury in experimental fatty liver disease. PLoS One. 2014; 9(12):e113651. Povero D, Eguchi A, Li H, Johnson CD, Papouchado BG, Wree A, Messer K, Feldstein AE. PMID: 25470250.
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    71. Transient receptor potential vanilloid 1 gene deficiency ameliorates hepatic injury in a mouse model of chronic binge alcohol-induced alcoholic liver disease. Am J Pathol. 2015 Jan; 185(1):43-54. Liu H, Beier JI, Arteel GE, Ramsden CE, Feldstein AE, McClain CJ, Kirpich IA. PMID: 25447051.
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    72. Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis. PLoS One. 2014; 9(9):e107658. Lazic M, Inzaugarat ME, Povero D, Zhao IC, Chen M, Nalbandian M, Miller YI, Cherñavsky AC, Feldstein AE, Sears DD. PMID: 25251155.
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    73. Arginase 2 deficiency results in spontaneous steatohepatitis: a novel link between innate immune activation and hepatic de novo lipogenesis. J Hepatol. 2015 Feb; 62(2):412-20. Navarro LA, Wree A, Povero D, Berk MP, Eguchi A, Ghosh S, Papouchado BG, Erzurum SC, Feldstein AE. PMID: 25234945.
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    74. Adipocyte cell size, free fatty acids and apolipoproteins are associated with non-alcoholic liver injury progression in severely obese patients. Metabolism. 2014 Dec; 63(12):1542-52. Wree A, Schlattjan M, Bechmann LP, Claudel T, Sowa JP, Stojakovic T, Scharnagl H, Köfeler H, Baba HA, Gerken G, Feldstein AE, Trauner M, Canbay A. PMID: 25267016.
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    75. Adipocyte cell death, fatty liver disease and associated metabolic disorders. Dig Dis. 2014; 32(5):579-85. Eguchi A, Feldstein AE. PMID: 25034291.
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    76. NLRP3 inflammasome activation is required for fibrosis development in NAFLD. J Mol Med (Berl). 2014 Oct; 92(10):1069-82. Wree A, McGeough MD, Peña CA, Schlattjan M, Li H, Inzaugarat ME, Messer K, Canbay A, Hoffman HM, Feldstein AE. PMID: 24861026.
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    77. Caspase 3 inactivation protects against hepatic cell death and ameliorates fibrogenesis in a diet-induced NASH model. Dig Dis Sci. 2014 Jun; 59(6):1197-206. Thapaliya S, Wree A, Povero D, Inzaugarat ME, Berk M, Dixon L, Papouchado BG, Feldstein AE. PMID: 24795036.
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    78. Letter: gender-associated cell-free microRNA profiles in non-alcoholic fatty liver disease--authors' reply. Aliment Pharmacol Ther. 2014 May; 39(9):999. Newton KP, Awai HI, Feldstein AE, Schwimmer JB. PMID: 24689350.
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    79. Leptin deficiency recapitulates the histological features of pulmonary arterial hypertension in mice. Int J Clin Exp Pathol. 2014; 7(5):1935-46. Aytekin M, Tonelli AR, Farver CF, Feldstein AE, Dweik RA. PMID: 24966903.
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    80. Lipidomic profiling of bile in distinguishing benign from malignant biliary strictures: a single-blinded pilot study. Am J Gastroenterol. 2014 Jun; 109(6):895-902. Navaneethan U, Gutierrez NG, Venkatesh PG, Jegadeesan R, Zhang R, Jang S, Sanaka MR, Vargo JJ, Parsi MA, Feldstein AE, Stevens T. PMID: 24710507.
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    81. Differential regulation of inflammation and apoptosis in Fas-resistant hepatocyte-specific Bid-deficient mice. J Hepatol. 2014 Jul; 61(1):107-15. Lazic M, Eguchi A, Berk MP, Povero D, Papouchado B, Mulya A, Johnson CD, Feldstein AE. PMID: 24681344.
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    82. [Cytokeratin 18 as marker for non-invasive diagnosis and prognosis of acute and chronic liver diseases]. Z Gastroenterol. 2014 Mar; 52(3):290-5. Canbay A, Feldstein A, Kronenberger B, Schulze-Osthoff K, Bantel H. PMID: 24622872.
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    83. Obesity, nutrition, and liver disease in children. Clin Liver Dis. 2014 Feb; 18(1):219-31. Feldstein AE, Patton-Ku D, Boutelle KN. PMID: 24274876.
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    84. NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice. Hepatology. 2014 Mar; 59(3):898-910. Wree A, Eguchi A, McGeough MD, Pena CA, Johnson CD, Canbay A, Hoffman HM, Feldstein AE. PMID: 23813842.
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    85. OxNASH score correlates with histologic features and severity of nonalcoholic fatty liver disease. Dig Dis Sci. 2014 Jul; 59(7):1617-24. Alkhouri N, Berk M, Yerian L, Lopez R, Chung YM, Zhang R, McIntyre TM, Feldstein AE, Hazen SL. PMID: 24464211.
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    86. Biomarkers of liver cell death. J Hepatol. 2014 May; 60(5):1063-74. Eguchi A, Wree A, Feldstein AE. PMID: 24412608.
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    87. Dipeptidyl peptidase IV inhibitor lowers PPAR? agonist-induced body weight gain by affecting food intake, fat mass, and beige/brown fat but not fluid retention. Am J Physiol Endocrinol Metab. 2014 Feb 15; 306(4):E388-98. Masuda T, Fu Y, Eguchi A, Czogalla J, Rose MA, Kuczkowski A, Gerasimova M, Feldstein AE, Scadeng M, Vallon V. PMID: 24347054.
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    88. Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal Controls. Gastroenterol Res Pract. 2013; 2013:498296. Patel NS, Peterson MR, Lin GY, Feldstein A, Schnabl B, Bettencourt R, Seki E, Sirlin CB, Loomba R. PMID: 24348536.
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    90. Health-related quality of life in children with autoimmune liver disease. J Pediatr Gastroenterol Nutr. 2013 Oct; 57(4):444-50. Gulati R, Radhakrishnan KR, Hupertz V, Wyllie R, Alkhouri N, Worley S, Feldstein AE. PMID: 23783017.
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    91. From NAFLD to NASH to cirrhosis-new insights into disease mechanisms. Nat Rev Gastroenterol Hepatol. 2013 Nov; 10(11):627-36. Wree A, Broderick L, Canbay A, Hoffman HM, Feldstein AE. PMID: 23958599.
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    92. Limited value of plasma cytokeratin-18 as a biomarker for NASH and fibrosis in patients with non-alcoholic fatty liver disease. J Hepatol. 2014 Jan; 60(1):167-74. Cusi K, Chang Z, Harrison S, Lomonaco R, Bril F, Orsak B, Ortiz-Lopez C, Hecht J, Feldstein AE, Webb A, Louden C, Goros M, Tio F. PMID: 23973932.
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    93. Oxidized fatty acids: A potential pathogenic link between fatty liver and type 2 diabetes in obese adolescents? Antioxid Redox Signal. 2014 Jan 10; 20(2):383-9. Santoro N, Caprio S, Giannini C, Kim G, Kursawe R, Pierpont B, Shaw MM, Feldstein AE. PMID: 23815500.
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    94. Oxidized metabolites of linoleic acid as biomarkers of liver injury in nonalcoholic steatohepatitis. Clin Lipidol. 2013 Aug 01; 8(4):411-418. Santoro N, Caprio S, Feldstein AE. PMID: 26405460.
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    95. Stearoyl-CoA desaturase plays an important role in proliferation and chemoresistance in human hepatocellular carcinoma. J Surg Res. 2014 Jan; 186(1):29-38. Bansal S, Berk M, Alkhouri N, Partrick DA, Fung JJ, Feldstein A. PMID: 24135379.
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    96. Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial. Pain. 2013 Nov; 154(11):2441-51. Ramsden CE, Faurot KR, Zamora D, Suchindran CM, Macintosh BA, Gaylord S, Ringel A, Hibbeln JR, Feldstein AE, Mori TA, Barden A, Lynch C, Coble R, Mas E, Palsson O, Barrow DA, Mann JD. PMID: 23886520.
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    97. Serum bilirubin level is inversely associated with nonalcoholic steatohepatitis in children. J Pediatr Gastroenterol Nutr. 2013 Jul; 57(1):114-8. Puri K, Nobili V, Melville K, Corte CD, Sartorelli MR, Lopez R, Feldstein AE, Alkhouri N. PMID: 23518490.
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    98. Mice lacking C1q are protected from high fat diet-induced hepatic insulin resistance and impaired glucose homeostasis. J Biol Chem. 2013 Aug 02; 288(31):22565-75. Hillian AD, McMullen MR, Sebastian BM, Roychowdhury S, Rowchowdhury S, Kashyap SR, Schauer PR, Kirwan JP, Feldstein AE, Nagy LE. PMID: 23788643.
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    99. Serum cytokeratin-18 fragment levels are useful biomarkers for nonalcoholic steatohepatitis in children. Am J Gastroenterol. 2013 Sep; 108(9):1526-31. Feldstein AE, Alkhouri N, De Vito R, Alisi A, Lopez R, Nobili V. PMID: 23752877.
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    100. Circulating levels of FGF-21 in obese youth: associations with liver fat content and markers of liver damage. J Clin Endocrinol Metab. 2013 Jul; 98(7):2993-3000. Giannini C, Feldstein AE, Santoro N, Kim G, Kursawe R, Pierpont B, Caprio S. PMID: 23626003.
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    101. Novel therapeutic targets for nonalcoholic fatty liver disease. Expert Opin Ther Targets. 2013 Jul; 17(7):773-9. Eguchi A, Povero D, Alkhouri N, Feldstein AE. PMID: 23600493.
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    102. Lysosomal Cathepsin D contributes to cell death during adipocyte hypertrophy. Adipocyte. 2013 Jul 01; 2(3):170-5. Eguchi A, Feldstein AE. PMID: 23991364.
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    103. Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis. PLoS One. 2013; 8(2):e56100. Dixon LJ, Flask CA, Papouchado BG, Feldstein AE, Nagy LE. PMID: 23409132.
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    104. The association between hepatic fat content and liver injury in obese children and adolescents: effects of ethnicity, insulin resistance, and common gene variants. Diabetes Care. 2013 May; 36(5):1353-60. Santoro N, Feldstein AE, Enoksson E, Pierpont B, Kursawe R, Kim G, Caprio S. PMID: 23275357.
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    105. Combined paediatric NAFLD fibrosis index and transient elastography to predict clinically significant fibrosis in children with fatty liver disease. Liver Int. 2013 Jan; 33(1):79-85. Alkhouri N, Sedki E, Alisi A, Lopez R, Pinzani M, Feldstein AE, Nobili V. PMID: 23146095.
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    106. Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism. Hepatology. 2012 Oct; 56(4):1291-9. Zein CO, Lopez R, Fu X, Kirwan JP, Yerian LM, McCullough AJ, Hazen SL, Feldstein AE. PMID: 22505276.
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    107. Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. Prostaglandins Leukot Essent Fatty Acids. 2012 Oct-Nov; 87(4-5):135-41. Ramsden CE, Ringel A, Feldstein AE, Taha AY, MacIntosh BA, Hibbeln JR, Majchrzak-Hong SF, Faurot KR, Rapoport SI, Cheon Y, Chung YM, Berk M, Mann JD. PMID: 22959954.
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    108. Longitudinal effects of MRI-measured hepatic steatosis on biomarkers of glucose homeostasis and hepatic apoptosis in obese youth. Diabetes Care. 2013 Jan; 36(1):130-6. Kim G, Giannini C, Pierpont B, Feldstein AE, Santoro N, Kursawe R, Shaw M, Duran E, Goldberg R, Dziura J, Caprio S. PMID: 22933439.
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    109. Development and validation of a new histological score for pediatric non-alcoholic fatty liver disease. J Hepatol. 2012 Dec; 57(6):1312-8. Alkhouri N, De Vito R, Alisi A, Yerian L, Lopez R, Feldstein AE, Nobili V. PMID: 22871498.
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    110. Adipocyte hypertrophy is associated with lysosomal permeability both in vivo and in vitro: role in adipose tissue inflammation. Am J Physiol Endocrinol Metab. 2012 Sep 01; 303(5):E597-606. Gornicka A, Fettig J, Eguchi A, Berk MP, Thapaliya S, Dixon LJ, Feldstein AE. PMID: 22739104.
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    111. Lipidomic profiling of serum and pancreatic fluid in chronic pancreatitis. Pancreas. 2012 May; 41(4):518-22. Stevens T, Berk MP, Lopez R, Chung YM, Zhang R, Parsi MA, Bronner MP, Feldstein AE. PMID: 22504378.
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    112. Markers of activated inflammatory cells correlate with severity of liver damage in children with nonalcoholic fatty liver disease. Int J Mol Med. 2012 Jul; 30(1):49-56. De Vito R, Alisi A, Masotti A, Ceccarelli S, Panera N, Citti A, Salata M, Valenti L, Feldstein AE, Nobili V. PMID: 22505182.
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    113. Leptin levels predict survival in pulmonary arterial hypertension. Pulm Circ. 2012 Apr-Jun; 2(2):214-9. Tonelli AR, Aytekin M, Feldstein AE, Dweik RA. PMID: 22837862.
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    116. Inhibition of apoptosis protects mice from ethanol-mediated acceleration of early markers of CCl4 -induced fibrosis but not steatosis or inflammation. Alcohol Clin Exp Res. 2012 Jul; 36(7):1139-47. Roychowdhury S, Chiang DJ, Mandal P, McMullen MR, Liu X, Cohen JI, Pollard J, Feldstein AE, Nagy LE. PMID: 22273278.
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    117. Pediatric nonalcoholic fatty liver disease: a multidisciplinary approach. Nat Rev Gastroenterol Hepatol. 2012 Jan 17; 9(3):152-61. Alisi A, Feldstein AE, Villani A, Raponi M, Nobili V. PMID: 22249728.
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    118. Mean platelet volume as a marker of increased cardiovascular risk in patients with nonalcoholic steatohepatitis. Hepatology. 2012 Jan; 55(1):331. Alkhouri N, Kistangari G, Campbell C, Lopez R, Zein NN, Feldstein AE. PMID: 21969091.
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    119. Response to hepatitis A vaccine in children with inflammatory bowel disease receiving infliximab. Inflamm Bowel Dis. 2011 Dec; 17(12):E160. Moses J, Alkhouri N, Shannon A, Feldstein A, Carter-Kent C. PMID: 21953938.
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    120. Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease. Liver Int. 2012 Feb; 32(2):297-302. Alkhouri N, Morris-Stiff G, Campbell C, Lopez R, Tamimi TA, Yerian L, Zein NN, Feldstein AE. PMID: 22097893.
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    121. Hepatitis B immunity and response to booster vaccination in children with inflammatory bowel disease treated with infliximab. Am J Gastroenterol. 2012 Jan; 107(1):133-8. Moses J, Alkhouri N, Shannon A, Raig K, Lopez R, Danziger-Isakov L, Feldstein AE, Zein NN, Wyllie R, Carter-Kent C. PMID: 21876562.
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    122. Pentoxifylline improves nonalcoholic steatohepatitis: a randomized placebo-controlled trial. Hepatology. 2011 Nov; 54(5):1610-9. Zein CO, Yerian LM, Gogate P, Lopez R, Kirwan JP, Feldstein AE, McCullough AJ. PMID: 21748765.
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    123. Identification of a cytochrome P4502E1/Bid/C1q-dependent axis mediating inflammation in adipose tissue after chronic ethanol feeding to mice. J Biol Chem. 2011 Oct 14; 286(41):35989-97. Sebastian BM, Roychowdhury S, Tang H, Hillian AD, Feldstein AE, Stahl GL, Takahashi K, Nagy LE. PMID: 21856753.
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    124. The use of ultrasound in clinical setting for children affected by NAFLD: is it safe and accurate? Ital J Pediatr. 2011 Aug 02; 37:36. Nobili V, Della Corte C, Monti L, Alisi A, Feldstein A. PMID: 21810223.
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    125. Ultrasonographic quantitative estimation of hepatic steatosis in children With NAFLD. J Pediatr Gastroenterol Nutr. 2011 Aug; 53(2):190-5. Shannon A, Alkhouri N, Carter-Kent C, Monti L, Devito R, Lopez R, Feldstein AE, Nobili V. PMID: 21788761.
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    126. The role of lifestyle changes in the management of chronic liver disease. BMC Med. 2011 Jun 06; 9:70. Nobili V, Carter-Kent C, Feldstein AE. PMID: 21645344.
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    127. Atherogenic dyslipidemia and cardiovascular risk in children with nonalcoholic fatty liver disease. Clin Lipidol. 2011 Jun 01; 6(3):305-314. Alkhouri N, Carter-Kent C, Elias M, Feldstein AE. PMID: 22162978.
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    129. NASH animal models: are we there yet? J Hepatol. 2011 Oct; 55(4):941-3. Kohli R, Feldstein AE. PMID: 21708199.
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    130. Transcriptional profile of genes involved in oxidative stress and antioxidant defense in a dietary murine model of steatohepatitis. Antioxid Redox Signal. 2011 Jul 15; 15(2):437-45. Gornicka A, Morris-Stiff G, Thapaliya S, Papouchado BG, Berk M, Feldstein AE. PMID: 21194384.
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    131. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 2011 Apr 07; 472(7341):57-63. Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WH, DiDonato JA, Lusis AJ, Hazen SL. PMID: 21475195.
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    132. Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications. Expert Rev Gastroenterol Hepatol. 2011 Apr; 5(2):201-12. Alkhouri N, Carter-Kent C, Feldstein AE. PMID: 21476915.
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    133. An apoptosis panel for nonalcoholic steatohepatitis diagnosis. J Hepatol. 2011 Jun; 54(6):1224-9. Tamimi TI, Elgouhari HM, Alkhouri N, Yerian LM, Berk MP, Lopez R, Schauer PR, Zein NN, Feldstein AE. PMID: 21145805.
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    134. Non-invasive diagnosis of nonalcoholic fatty liver and nonalcoholic steatohepatitis. J Dig Dis. 2011 Feb; 12(1):10-6. Adams LA, Feldstein AE. PMID: 21091933.
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    135. Relations of steatosis type, grade, and zonality to histological features in pediatric nonalcoholic fatty liver disease. J Pediatr Gastroenterol Nutr. 2011 Feb; 52(2):190-7. Carter-Kent C, Brunt EM, Yerian LM, Alkhouri N, Angulo P, Kohli R, Ling SC, Xanthakos SA, Whitington PF, Charatcharoenwitthaya P, Yap J, Lopez R, McCullough AJ, Feldstein AE. PMID: 21240012.
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    136. Recurrence of Disease Following Liver Transplantation: Nonalcoholic Steatohepatitis vs Hepatitis C Virus Infection. Int J Organ Transplant Med. 2011; 2(2):57-65. Hanouneh IA, Macaron C, Lopez R, Feldstein AE, Yerian L, Eghtesad B, Zein NN. PMID: 25013596.
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    138. Biomarkers in nonalcoholic fatty liver disease: a new era in diagnosis and staging of disease in children. J Pediatr Gastroenterol Nutr. 2010 Oct; 51(4):378-9. Feldstein AE, Nobili V. PMID: 20808243.
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    139. A combination of the pediatric NAFLD fibrosis index and enhanced liver fibrosis test identifies children with fibrosis. Clin Gastroenterol Hepatol. 2011 Feb; 9(2):150-5. Alkhouri N, Carter-Kent C, Lopez R, Rosenberg WM, Pinzani M, Bedogni G, Feldstein AE, Nobili V. PMID: 20888433.
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    140. Nonalcoholic steatohepatitis: risk factors and diagnosis. Expert Rev Gastroenterol Hepatol. 2010 Oct; 4(5):623-35. Adams LA, Feldstein AE. PMID: 20932147.
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    141. High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology. 2010 Sep; 52(3):934-44. Kohli R, Kirby M, Xanthakos SA, Softic S, Feldstein AE, Saxena V, Tang PH, Miles L, Miles MV, Balistreri WF, Woods SC, Seeley RJ. PMID: 20607689.
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    142. Fibroblast growth factor 21 as a biomarker for NAFLD: integrating pathobiology into clinical practice. J Hepatol. 2010 Nov; 53(5):795-6. Morris-Stiff G, Feldstein AE. PMID: 20800308.
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    143. Mass spectrometric profiling of oxidized lipid products in human nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. J Lipid Res. 2010 Oct; 51(10):3046-54. Feldstein AE, Lopez R, Tamimi TA, Yerian L, Chung YM, Berk M, Zhang R, McIntyre TM, Hazen SL. PMID: 20631297.
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    144. Severity of liver injury and atherogenic lipid profile in children with nonalcoholic fatty liver disease. Pediatr Res. 2010 Jun; 67(6):665-70. Nobili V, Alkhouri N, Bartuli A, Manco M, Lopez R, Alisi A, Feldstein AE. PMID: 20496475.
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    145. Chronic alcohol exposure increases circulating bioactive oxidized phospholipids. J Biol Chem. 2010 Jul 16; 285(29):22211-20. Yang L, Latchoumycandane C, McMullen MR, Pratt BT, Zhang R, Papouchado BG, Nagy LE, Feldstein AE, McIntyre TM. PMID: 20460374.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    146. Autoimmune hepatitis in children--impact of cirrhosis at presentation on natural history and long-term outcome. Dig Liver Dis. 2010 Oct; 42(10):724-8. Radhakrishnan KR, Alkhouri N, Worley S, Arrigain S, Hupertz V, Kay M, Yerian L, Wyllie R, Feldstein AE. PMID: 20163994.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    147. The inflamed liver and atherosclerosis: a link between histologic severity of nonalcoholic fatty liver disease and increased cardiovascular risk. Dig Dis Sci. 2010 Sep; 55(9):2644-50. Alkhouri N, Tamimi TA, Yerian L, Lopez R, Zein NN, Feldstein AE. PMID: 19960252.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    148. Diabetes mellitus is associated with impaired response to antiviral therapy in chronic hepatitis C infection. Dig Dis Sci. 2009 Dec; 54(12):2699-705. Elgouhari HM, Zein CO, Hanouneh I, Feldstein AE, Zein NN. PMID: 19148751.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    149. Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis. J Biol Chem. 2010 Jan 29; 285(5):3428-38. Alkhouri N, Gornicka A, Berk MP, Thapaliya S, Dixon LJ, Kashyap S, Schauer PR, Feldstein AE. PMID: 19940134.
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    150. Serum retinol-binding protein 4 levels in patients with nonalcoholic fatty liver disease. J Clin Gastroenterol. 2009 Nov-Dec; 43(10):985-9. Alkhouri N, Lopez R, Berk M, Feldstein AE. PMID: 19525859.
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    151. Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study. Hepatology. 2009 Oct; 50(4):1113-20. Carter-Kent C, Yerian LM, Brunt EM, Angulo P, Kohli R, Ling SC, Xanthakos SA, Whitington PF, Charatcharoenwitthaya P, Yap J, Lopez R, McCullough AJ, Feldstein AE. PMID: 19637190.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    152. Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study. Hepatology. 2009 Oct; 50(4):1072-8. Feldstein AE, Wieckowska A, Lopez AR, Liu YC, Zein NN, McCullough AJ. PMID: 19585618.
      View in: PubMed   Mentions: 184     Fields:    Translation:Humans
    153. Suppression of mitochondrial function by oxidatively truncated phospholipids is reversible, aided by bid, and suppressed by Bcl-XL. J Biol Chem. 2009 Sep 25; 284(39):26297-308. Chen R, Feldstein AE, McIntyre TM. PMID: 19654426.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    154. Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal. Expert Rev Gastroenterol Hepatol. 2009 Aug; 3(4):445-51. Alkhouri N, Dixon LJ, Feldstein AE. PMID: 19673631.
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    155. Non-alcoholic steatohepatitis over multiple generations. Dig Dis Sci. 2010 May; 55(5):1494-7. Carter-Kent C, Feldstein AE. PMID: 19629685.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    156. The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years. Gut. 2009 Nov; 58(11):1538-44. Feldstein AE, Charatcharoenwitthaya P, Treeprasertsuk S, Benson JT, Enders FB, Angulo P. PMID: 19625277.
      View in: PubMed   Mentions: 163     Fields:    Translation:Humans
    157. Triglyceride levels and not adipokine concentrations are closely related to severity of nonalcoholic fatty liver disease in an obesity surgery cohort. Obesity (Silver Spring). 2009 Sep; 17(9):1696-701. Kashyap SR, Diab DL, Baker AR, Yerian L, Bajaj H, Gray-McGuire C, Schauer PR, Gupta M, Feldstein AE, Hazen SL, Stein CM. PMID: 19360015.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    158. Severe hepatocellular injury with apoptosis induced by a hepatitis C polymerase inhibitor. J Clin Gastroenterol. 2009 Apr; 43(4):374-81. Feldstein A, Kleiner D, Kravetz D, Buck M. PMID: 19098685.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    159. Role of interleukin-6 in human nonalcoholic steatohepatitis. Response to Dogru et al. Am J Gastroenterol. 2009 Mar; 104(3):author reply 788. Wieckowska A, Papouchado BG, Li Z, Lopez R, Zein NN, Feldstein AE. PMID: 19174778.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    160. Retinol-binding protein 4: a promising circulating marker of liver damage in pediatric nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2009 May; 7(5):575-9. Nobili V, Alkhouri N, Alisi A, Ottino S, Lopez R, Manco M, Feldstein AE. PMID: 19268270.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    161. Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase. J Biol Chem. 2009 Feb 27; 284(9):5637-44. Li ZZ, Berk M, McIntyre TM, Feldstein AE. PMID: 19119140.
      View in: PubMed   Mentions: 144     Fields:    Translation:AnimalsCells
    162. Diagnosis of nonalcoholic fatty liver disease: invasive versus noninvasive. Semin Liver Dis. 2008 Nov; 28(4):386-95. Wieckowska A, Feldstein AE. PMID: 18956295.
      View in: PubMed   Mentions: 81     Fields:    Translation:Humans
    163. The significance of metabolic syndrome in the setting of recurrent hepatitis C after liver transplantation. Liver Transpl. 2008 Sep; 14(9):1287-93. Hanouneh IA, Feldstein AE, McCullough AJ, Miller C, Aucejo F, Yerian L, Lopez R, Zein NN. PMID: 18756451.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    164. Cytokeratin 18 fragment levels as a noninvasive biomarker for nonalcoholic steatohepatitis in bariatric surgery patients. Clin Gastroenterol Hepatol. 2008 Nov; 6(11):1249-54. Diab DL, Yerian L, Schauer P, Kashyap SR, Lopez R, Hazen SL, Feldstein AE. PMID: 18995215.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    165. Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis. Am J Gastroenterol. 2008 Jun; 103(6):1372-9. Wieckowska A, Papouchado BG, Li Z, Lopez R, Zein NN, Feldstein AE. PMID: 18510618.
      View in: PubMed   Mentions: 166     Fields:    Translation:Humans
    166. Clinical significance of metabolic syndrome in the setting of chronic hepatitis C virus infection. Clin Gastroenterol Hepatol. 2008 May; 6(5):584-9. Hanouneh IA, Feldstein AE, Lopez R, Yerian L, Pillai A, Zein CO, Zein NN. PMID: 18455698.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    167. The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity. Hepatology. 2008 May; 47(5):1495-503. Li Z, Berk M, McIntyre TM, Gores GJ, Feldstein AE. PMID: 18220271.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    168. Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: implications for treatment. Am J Gastroenterol. 2008 Apr; 103(4):1036-42. Carter-Kent C, Zein NN, Feldstein AE. PMID: 18177455.
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    169. Increasing calories, decreasing morbidity and mortality: is improved nutrition the answer to better outcomes in patients with biliary atresia? Hepatology. 2007 Nov; 46(5):1329-31. Carter-Kent C, Radhakrishnan K, Feldstein AE. PMID: 17969044.
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    170. Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future. Hepatology. 2007 Aug; 46(2):582-9. Wieckowska A, McCullough AJ, Feldstein AE. PMID: 17661414.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansCells
    171. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology. 2006 Jul; 44(1):27-33. Wieckowska A, Zein NN, Yerian LM, Lopez AR, McCullough AJ, Feldstein AE. PMID: 16799979.
      View in: PubMed   Mentions: 182     Fields:    Translation:HumansCells
    172. Bax inhibition protects against free fatty acid-induced lysosomal permeabilization. Am J Physiol Gastrointest Liver Physiol. 2006 Jun; 290(6):G1339-46. Feldstein AE, Werneburg NW, Li Z, Bronk SF, Gores GJ. PMID: 16484678.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    173. Nonalcoholic fatty liver disease in the pediatric population: a review. Curr Opin Pediatr. 2005 Oct; 17(5):636-41. Wieckowska A, Feldstein AE. PMID: 16160540.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    174. Apoptosis in alcoholic and nonalcoholic steatohepatitis. Front Biosci. 2005 Sep 01; 10:3093-9. Feldstein AE, Gores GJ. PMID: 15970563.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    175. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology. 2005 Jul; 129(1):113-21. Adams LA, Lymp JF, St Sauver J, Sanderson SO, Lindor KD, Feldstein A, Angulo P. PMID: 16012941.
      View in: PubMed   Mentions: 764     Fields:    Translation:Humans
    176. Hepatic stellate cells and fibrosis progression in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2005 Apr; 3(4):384-9. Feldstein AE, Papouchado BG, Angulo P, Sanderson S, Adams L, Gores GJ. PMID: 15822044.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    177. An apoptosis biomarker goes to the HCV clinic. Hepatology. 2004 Nov; 40(5):1044-6. Feldstein AE, Gores GJ. PMID: 15486920.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    178. Steatohepatitis and apoptosis: therapeutic implications. Am J Gastroenterol. 2004 Sep; 99(9):1718-9. Feldstein A, Gores GJ. PMID: 15330908.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    179. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology. 2004 Jul; 40(1):185-94. Feldstein AE, Werneburg NW, Canbay A, Guicciardi ME, Bronk SF, Rydzewski R, Burgart LJ, Gores GJ. PMID: 15239102.
      View in: PubMed   Mentions: 223     Fields:    Translation:HumansAnimalsCells
    180. Nonalcoholic fatty liver disease among patients with hypothalamic and pituitary dysfunction. Hepatology. 2004 Apr; 39(4):909-14. Adams LA, Feldstein A, Lindor KD, Angulo P. PMID: 15057893.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    181. Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice. J Hepatol. 2003 Dec; 39(6):978-83. Feldstein AE, Canbay A, Guicciardi ME, Higuchi H, Bronk SF, Gores GJ. PMID: 14642615.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    182. The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse. J Pharmacol Exp Ther. 2004 Mar; 308(3):1191-6. Canbay A, Feldstein A, Baskin-Bey E, Bronk SF, Gores GJ. PMID: 14617689.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    183. Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression. Hepatology. 2003 Nov; 38(5):1188-98. Canbay A, Feldstein AE, Higuchi H, Werneburg N, Grambihler A, Bronk SF, Gores GJ. PMID: 14578857.
      View in: PubMed   Mentions: 137     Fields:    Translation:AnimalsCells
    184. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology. 2003 Aug; 125(2):437-43. Feldstein AE, Canbay A, Angulo P, Taniai M, Burgart LJ, Lindor KD, Gores GJ. PMID: 12891546.
      View in: PubMed   Mentions: 295     Fields:    Translation:HumansCells
    185. Primary sclerosing cholangitis in children: a long-term follow-up study. Hepatology. 2003 Jul; 38(1):210-7. Feldstein AE, Perrault J, El-Youssif M, Lindor KD, Freese DK, Angulo P. PMID: 12830004.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    186. Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis. J Clin Invest. 2003 Jul; 112(2):152-9. Canbay A, Guicciardi ME, Higuchi H, Feldstein A, Bronk SF, Rydzewski R, Taniai M, Gores GJ. PMID: 12865404.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    187. Lipid-lowering-independent effects of simvastatin on the kidney in experimental hypercholesterolaemia. Nephrol Dial Transplant. 2003 Apr; 18(4):703-9. Wilson SH, Chade AR, Feldstein A, Sawamura T, Napoli C, Lerman A, Lerman LO. PMID: 12637638.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    188. Chronic intestinal pseudoobstruction associated with altered interstitial cells of cajal networks. J Pediatr Gastroenterol Nutr. 2003 Apr; 36(4):492-7. Feldstein AE, Miller SM, El-Youssef M, Rodeberg D, Lindor NM, Burgart LJ, Szurszewski JH, Farrugia G. PMID: 12658043.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    189. Prevalence and clinical significance of human herpesviruses 6 and 7 active infection in pediatric liver transplant patients. Pediatr Transplant. 2003 Apr; 7(2):125-9. Feldstein AE, Razonable RR, Boyce TG, Freese DK, El-Youssef M, Perrault J, Paya CV, Ishitani MB. PMID: 12654053.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    190. In vivo renal vascular and tubular function in experimental hypercholesterolemia. Hypertension. 1999 Oct; 34(4 Pt 2):859-64. Feldstein A, Krier JD, Sarafov MH, Lerman A, Best PJ, Wilson SH, Lerman LO. PMID: 10523374.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    191. New insights into the pathophysiology of renovascular hypertension. Mayo Clin Proc. 1997 Mar; 72(3):251-60. Romero JC, Feldstein AE, Rodriguez-Porcel MG, Cases-Amenos A. PMID: 9070202.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    192. The effect of ethanol on the in vivo conversion of 5-HTP-14C to serotonin-14C, 5-hydroxyindoleacetaldehyde-14C and its metabolites in rat brain. Int J Neuropharmacol. 1969 Jul; 8(4):347-51. Feldstein A, Sidel CM. PMID: 5307042.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
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