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Ariel Feldstein

Title(s)Professor, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
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    Hepatocyte-derived extracellular vesicles in alcoholic liver disease
    NIH R01AA028134Jul 1, 2020 - Mar 31, 2025
    Role: Principal Investigator
    Gain of function mutations in inflammasome related genes in human and experimental alcoholic liver disease
    NIH R01AA024206Sep 20, 2017 - Aug 31, 2022
    Role: Principal Investigator
    Gain of function mutations in inflammasome related genes in human and experimental alcoholic liver disease
    NIH U01AA024206Sep 20, 2017 - Aug 31, 2022
    Role: Principal Investigator
    Sterile inflammation and pyroptotic cell death in liver fibrosis
    NIH R01DK113592Mar 1, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Encapsulated RNAs in extracellular vesicles contribute ALD progression
    NIH R21AA023574Sep 5, 2015 - Aug 31, 2018
    Role: Principal Investigator
    Oxidized Metabolites of Linoleic Acid in Alcohol-induced Liver Injury
    NIH U01AA022489Sep 1, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Alcoholic liver disease: Biochemical, cellular and systemic responses to ethanol
    NIH P20AA017837Sep 30, 2009 - Aug 31, 2014
    Role: Co-Investigator
    Caspase Dependent Cell Death in Nonalcoholic Fatty Liver Disease
    NIH R01DK082451Aug 24, 2009 - Jul 4, 2011
    Role: Principal Investigator
    The Lysosomal-Mitochondrial Axis in Nonalcoholic Fatty Liver Disease
    NIH R01DK076852Mar 1, 2007 - Jul 4, 2011
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH. Cell Rep. 2021 Jan 12; 34(2):108626. Daemen S, Gainullina A, Kalugotla G, He L, Chan MM, Beals JW, Liss KH, Klein S, Feldstein AE, Finck BN, Artyomov MN, Schilling JD. PMID: 33440159.
      View in: PubMed   Mentions:    Fields:    
    2. The Power of Single-Cell Analysis for the Study of Liver Pathobiology. Hepatology. 2021 Jan; 73(1):437-448. PMID: 32740968.
      View in: PubMed   Mentions:    Fields:    
    3. Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis. Gut. 2020 Nov 18. Koh EH, Yoon JE, Ko MS, Leem J, Yun JY, Hong CH, Cho YK, Lee SE, Jang JE, Baek JY, Yoo HJ, Kim SJ, Sung CO, Lim JS, Jeong WI, Back SH, Baek IJ, Torres S, Solsona-Vilarrasa E, Rosa LC, Garcia-Ruiz C, Feldstein AE, Fernandez-Checa JC, Lee KU. PMID: 33208407.
      View in: PubMed   Mentions:    Fields:    
    4. A Low ?-6 to ?-3 PUFA Ratio (n-6:n-3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth. J Nutr. 2020 09 01; 150(9):2314-2321. Van Name MA, Savoye M, Chick JM, Galuppo BT, Feldstein AE, Pierpont B, Johnson C, Shabanova V, Ekong U, Valentino PL, Kim G, Caprio S, Santoro N. PMID: 32652034.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    5. Mechanisms of nonalcoholic fatty liver disease and implications for surgery. Langenbecks Arch Surg. 2020 Aug 24. Kaufmann B, Reca A, Wang B, Friess H, Feldstein AE, Hartmann D. PMID: 32833053.
      View in: PubMed   Mentions:    Fields:    
    6. Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis. J Hepatol. 2021 Jan; 74(1):156-167. PMID: 32763266.
      View in: PubMed   Mentions:    Fields:    
    7. Characterization and Proteome of Circulating Extracellular Vesicles as Potential Biomarkers for NASH. Hepatol Commun. 2020 Sep; 4(9):1263-1278. Povero D, Yamashita H, Ren W, Subramanian MG, Myers RP, Eguchi A, Simonetto DA, Goodman ZD, Harrison SA, Sanyal AJ, Bosch J, Feldstein AE. PMID: 32923831.
      View in: PubMed   Mentions:
    8. Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1ß and IL-17 upregulation in alcoholic hepatitis mice. J Mol Med (Berl). 2020 07; 98(7):1021-1034. Eguchi A, Yan R, Pan SQ, Wu R, Kim J, Chen Y, Ansong C, Smith RD, Tempaku M, Ohno-Machado L, Takei Y, Feldstein AE, Tsukamoto H. PMID: 32556367.
      View in: PubMed   Mentions: 1     Fields:    
    9. The NLRP3 Inflammasome in Alcoholic and Nonalcoholic Steatohepatitis. Semin Liver Dis. 2020 Aug; 40(3):298-306. Knorr J, Wree A, Tacke F, Feldstein AE. PMID: 32526788.
      View in: PubMed   Mentions: 3     Fields:    
    10. ASK1 inhibition reduces cell death and hepatic fibrosis in an Nlrp3 mutant liver injury model. JCI Insight. 2020 01 30; 5(2). Schuster-Gaul S, Geisler LJ, McGeough MD, Johnson CD, Zagorska A, Li L, Wree A, Barry V, Mikaelian I, Jih LJ, Papouchado BG, Budas G, Hoffman HM, Feldstein AE. PMID: 31996485.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    11. Identification of actin network proteins, talin-1 and filamin-A, in circulating extracellular vesicles as blood biomarkers for human myalgic encephalomyelitis/chronic fatigue syndrome. Brain Behav Immun. 2020 02; 84:106-114. Eguchi A, Fukuda S, Kuratsune H, Nojima J, Nakatomi Y, Watanabe Y, Feldstein AE. PMID: 31759091.
      View in: PubMed   Mentions: 2     Fields:    
    12. Designing Clinical Trials in Pediatric Nonalcoholic Steatohepatitis: Tips for Patient Selection and Appropriate Endpoints. Hepatol Commun. 2019 Dec; 3(12):1563-1570. Alkhouri N, Kohli R, Feldstein AE. PMID: 31832567.
      View in: PubMed   Mentions:
    13. MicroRNA 223 3p Negatively Regulates the NLRP3 Inflammasome in Acute and Chronic Liver Injury. Mol Ther. 2020 02 05; 28(2):653-663. Jimenez Calvente C, Del Pilar H, Tameda M, Johnson CD, Feldstein AE. PMID: 31585800.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    14. Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223. J Clin Invest. 2019 07 11; 129(10):4091-4109. Calvente CJ, Tameda M, Johnson CD, Del Pilar H, Lin YC, Adronikou N, De Mollerat Du Jeu X, Llorente C, Boyer J, Feldstein AE. PMID: 31295147.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    15. NAFLD in children: new genes, new diagnostic modalities and new drugs. Nat Rev Gastroenterol Hepatol. 2019 09; 16(9):517-530. Nobili V, Alisi A, Valenti L, Miele L, Feldstein AE, Alkhouri N. PMID: 31278377.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    16. Human induced pluripotent stem cell-derived extracellular vesicles reduce hepatic stellate cell activation and liver fibrosis. JCI Insight. 2019 06 11; 5. Povero D, Pinatel EM, Leszczynska A, Goyal NP, Nishio T, Kim J, Kneiber D, de Araujo Horcel L, Eguchi A, Ordonez PM, Kisseleva T, Feldstein AE. PMID: 31184999.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    17. Novel Drivers of the Inflammatory Response in Liver Injury and Fibrosis. Semin Liver Dis. 2019 07; 39(3):275-282. Wree A, Holtmann TM, Inzaugarat ME, Feldstein AE. PMID: 31100758.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    18. Extracellular vesicles, the liquid biopsy of the future. J Hepatol. 2019 06; 70(6):1292-1294. Eguchi A, Kostallari E, Feldstein AE, Shah VH. PMID: 30982591.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    19. NLR Family Pyrin Domain-Containing 3 Inflammasome Activation in Hepatic Stellate Cells Induces Liver Fibrosis in Mice. Hepatology. 2019 02; 69(2):845-859. Inzaugarat ME, Johnson CD, Holtmann TM, McGeough MD, Trautwein C, Papouchado BG, Schwabe R, Hoffman HM, Wree A, Feldstein AE. PMID: 30180270.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    20. Extracellular Vesicles in Liver Diseases: Meeting Report from the International Liver Congress 2018. Hepatol Commun. 2019 Feb; 3(2):305-315. Banales JM, Feldstein AE, Sänger H, Lukacs-Kornek V, Szabo G, Kornek M. PMID: 30766966.
      View in: PubMed   Mentions:
    21. Non-alcoholic fatty liver disease in pediatric type 2 diabetes: Metabolic and histologic characteristics in 38 subjects. Pediatr Diabetes. 2019 02; 20(1):41-47. Newfield RS, Graves CL, Newbury RO, Schwimmer JB, Proudfoot JA, Say DS, Feldstein AE. PMID: 30467936.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Differential Activation of Hepatic Invariant NKT Cell Subsets Plays a Key Role in Progression of Nonalcoholic Steatohepatitis. J Immunol. 2018 11 15; 201(10):3017-3035. Maricic I, Marrero I, Eguchi A, Nakamura R, Johnson CD, Dasgupta S, Hernandez CD, Nguyen PS, Swafford AD, Knight R, Feldstein AE, Loomba R, Kumar V. PMID: 30322964.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    23. Correction: Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein levels predict the presence of fibrotic nonalcoholic steatohepatitis (NASH) and NASH cirrhosis. PLoS One. 2018; 13(10):e0205541. Alkhouri N, Johnson C, Adams L, Kitajima S, Tsuruno C, Colpitts TL, Hatcho K, Lawitz E, Lopez R, Feldstein AE. PMID: 30286196.
      View in: PubMed   Mentions:    Fields:    
    24. Ethanol and unsaturated dietary fat induce unique patterns of hepatic ?-6 and ?-3 PUFA oxylipins in a mouse model of alcoholic liver disease. PLoS One. 2018; 13(9):e0204119. Warner DR, Liu H, Ghosh Dastidar S, Warner JB, Prodhan MAI, Yin X, Zhang X, Feldstein AE, Gao B, Prough RA, McClain CJ, Kirpich IA. PMID: 30256818.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    25. Complex Network of NKT Cell Subsets Controls Immune Homeostasis in Liver and Gut. Front Immunol. 2018; 9:2082. Marrero I, Maricic I, Feldstein AE, Loomba R, Schnabl B, Rivera-Nieves J, Eckmann L, Kumar V. PMID: 30254647.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    26. Liquid biopsy for liver diseases. Gut. 2018 12; 67(12):2204-2212. Mann J, Reeves HL, Feldstein AE. PMID: 30177542.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    27. Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein levels predict the presence of fibrotic nonalcoholic steatohepatitis (NASH) and NASH cirrhosis. PLoS One. 2018; 13(8):e0202226. Alkhouri N, Johnson C, Adams L, Kitajima S, Tsuruno C, Colpitts TL, Hatcho K, Lawitz E, Lopez R, Feldstein AE. PMID: 30161179.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    28. Effects of diets enriched in linoleic acid and its peroxidation products on brain fatty acids, oxylipins, and aldehydes in mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 10; 1863(10):1206-1213. Ramsden CE, Hennebelle M, Schuster S, Keyes GS, Johnson CD, Kirpich IA, Dahlen JE, Horowitz MS, Zamora D, Feldstein AE, McClain CJ, Muhlhausler BS, Makrides M, Gibson RA, Taha AY. PMID: 30053599.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    29. Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice. J Lipid Res. 2018 09; 59(9):1597-1609. Schuster S, Johnson CD, Hennebelle M, Holtmann T, Taha AY, Kirpich IA, Eguchi A, Ramsden CE, Papouchado BG, McClain CJ, Feldstein AE. PMID: 30084831.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    30. Triggering and resolution of inflammation in NASH. Nat Rev Gastroenterol Hepatol. 2018 06; 15(6):349-364. Schuster S, Cabrera D, Arrese M, Feldstein AE. PMID: 29740166.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    31. Emricasan, a pan-caspase inhibitor, improves survival and portal hypertension in a murine model of common bile-duct ligation. J Mol Med (Berl). 2018 06; 96(6):575-583. Eguchi A, Koyama Y, Wree A, Johnson CD, Nakamura R, Povero D, Kneiber D, Tameda M, Contreras P, Spada A, Feldstein AE. PMID: 29728708.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    32. Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress. Biomolecules. 2018 03 26; 8(2). PMID: 29587455.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    33. Extracellular vesicles in non-alcoholic and alcoholic fatty liver diseases. Liver Res. 2018 Mar; 2(1):30-34. Eguchi A, Feldstein AE. PMID: 30345152.
      View in: PubMed   Mentions:
    34. Transmembrane BAX Inhibitor motif-containing 1, a novel anti-inflammatory approach for nonalcoholic steatohepatitis treatment. Hepatology. 2018 01; 67(1):438-441. PMID: 28859227.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    35. NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL-17 and TNF in mice. Hepatology. 2018 02; 67(2):736-749. Wree A, McGeough MD, Inzaugarat ME, Eguchi A, Schuster S, Johnson CD, Peña CA, Geisler LJ, Papouchado BG, Hoffman HM, Feldstein AE. PMID: 28902427.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    36. TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies. J Clin Invest. 2017 12 01; 127(12):4488-4497. PMID: 29130929.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    37. Dietary Linoleic Acid and Its Oxidized Metabolites Exacerbate Liver Injury Caused by Ethanol via Induction of Hepatic Proinflammatory Response in Mice. Am J Pathol. 2017 Oct; 187(10):2232-2245. Warner DR, Liu H, Miller ME, Ramsden CE, Gao B, Feldstein AE, Schuster S, McClain CJ, Kirpich IA. PMID: 28923202.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    38. Traffic-related air pollution associations with cytokeratin-18, a marker of hepatocellular apoptosis, in an overweight and obese paediatric population. Pediatr Obes. 2018 06; 13(6):342-347. PMID: 28730729.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    39. Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis. Sci Rep. 2017 06 14; 7(1):3491. PMID: 28615649.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    40. Inflammasomes in Liver Fibrosis. Semin Liver Dis. 2017 05; 37(2):119-127. PMID: 28564720.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    41. Oxidized Derivatives of Linoleic Acid in Pediatric Metabolic Syndrome: Is Their Pathogenic Role Modulated by the Genetic Background and the Gut Microbiota? Antioxid Redox Signal. 2019 01 10; 30(2):241-250. PMID: 28279074.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    42. NASH-RELATED CIRRHOSIS: AN OCCULT LIVER DISEASE BURDEN. Hepatol Commun. 2017 Apr; 1(2):84-86. Arrese M, Feldstein AE. PMID: 29335681.
      View in: PubMed   Mentions:
    43. NASH: Novel therapeutic strategies targeting ASK1 in NASH. Nat Rev Gastroenterol Hepatol. 2017 06; 14(6):329-330. PMID: 28377639.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    44. Treating nonalcoholic steatohepatitis in children: Not a cinch task. Hepatology. 2017 04; 65(4):1407-1409. PMID: 28073147.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    45. Microvesicles released from fat-laden cells promote activation of hepatocellular NLRP3 inflammasome: A pro-inflammatory link between lipotoxicity and non-alcoholic steatohepatitis. PLoS One. 2017; 12(3):e0172575. PMID: 28249038.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    46. Update on lipid species and paediatric nonalcoholic fatty liver disease. Curr Opin Clin Nutr Metab Care. 2017 03; 20(2):110-116. PMID: 27906700.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    47. NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. J Hepatol. 2017 05; 66(5):1037-1046. PMID: 28167322.
      View in: PubMed   Mentions: 104     Fields:    Translation:Animals
    48. Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood. Hepatology. 2017 02; 65(2):475-490. PMID: 27639178.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    49. Fatty liver in adolescents: Mechanisms, clinical features and therapy. J Hepatol. 2016 12; 65(6):1258-1260. PMID: 27742132.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    50. Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress. J Mol Med (Berl). 2016 11; 94(11):1241-1253. PMID: 27394413.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    51. Hepatocyte mitochondrial DNA released in microparticles and toll-like receptor 9 activation: A link between lipotoxicity and inflammation during nonalcoholic steatohepatitis. Hepatology. 2016 08; 64(2):669-71. PMID: 27239763.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    52. Soluble IgM links apoptosis to complement activation in early alcoholic liver disease in mice. Mol Immunol. 2016 Apr; 72:9-18. PMID: 26922040.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    53. Targeting Cell Death and Sterile Inflammation Loop for the Treatment of Nonalcoholic Steatohepatitis. Semin Liver Dis. 2016 Feb; 36(1):27-36. PMID: 26870930.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    54. Innate Immunity and Inflammation in NAFLD/NASH. Dig Dis Sci. 2016 May; 61(5):1294-303. PMID: 26841783.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    55. Noninvasive diagnosis of nonalcoholic fatty liver disease: Are we there yet? Metabolism. 2016 Aug; 65(8):1087-95. PMID: 26972222.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    56. Novel Molecular Mechanisms in the Development of Non-Alcoholic Steatohepatitis. Diabetes Metab J. 2016 Feb; 40(1):1-11. PMID: 26912150.
      View in: PubMed   Mentions:
    57. Similarities and differences between pediatric and adult nonalcoholic fatty liver disease. Metabolism. 2016 Aug; 65(8):1161-71. PMID: 26961580.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    58. Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study. Hepatology. 2016 Jan; 63(1):117-25. PMID: 26457389.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    59. Liver Bid suppression for treatment of fibrosis associated with non-alcoholic steatohepatitis. J Hepatol. 2016 Mar; 64(3):699-707. PMID: 26555271.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    60. Lipid-induced hepatocyte-derived extracellular vesicles regulate hepatic stellate cell via microRNAs targeting PPAR-?. Cell Mol Gastroenterol Hepatol. 2015 Nov 01; 1(6):646-663.e4. PMID: 26783552.
      View in: PubMed   Mentions: 39     Fields:    
    61. Etiology, outcome and prognostic factors of childhood acute liver failure in a German Single Center. Ann Hepatol. 2015 Sep-Oct; 14(5):722-8. PMID: 26256901.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    62. Burden of nonalcoholic fatty liver disease and advanced fibrosis in a Texas Hispanic community cohort. World J Hepatol. 2015 Jun 18; 7(11):1586-94. PMID: 26085918.
      View in: PubMed   Mentions:
    63. Redox nanoparticles as a novel treatment approach for inflammation and fibrosis associated with nonalcoholic steatohepatitis. Nanomedicine (Lond). 2015; 10(17):2697-708. PMID: 26020857.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    64. Serum cytokeratin-18 fragment levels predict development of type 2 diabetes mellitus in adult patients with NAFLD. Liver Int. 2015 Dec; 35(12):2621. PMID: 25939859.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    65. Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation. Cell Death Differ. 2015 Dec; 22(12):1985-94. PMID: 25909884.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    66. Microparticles release by adipocytes act as "find-me" signals to promote macrophage migration. PLoS One. 2015; 10(4):e0123110. PMID: 25849214.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    67. Circulating Soluble Fas and Fas Ligand Levels Are Elevated in Children with Nonalcoholic Steatohepatitis. Dig Dis Sci. 2015 Aug; 60(8):2353-9. PMID: 25764498.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    68. Beneficial effects of mineralocorticoid receptor blockade in experimental non-alcoholic steatohepatitis. Liver Int. 2015 Sep; 35(9):2129-38. PMID: 25646700.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    69. Endoscopic treatment of pediatric post-transplant biliary complications is safe and effective. Dig Endosc. 2015 May; 27(4):505-511. PMID: 25545826.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    70. Circulating microRNAs: emerging biomarkers of liver disease. Semin Liver Dis. 2015 Feb; 35(1):43-54. PMID: 25632934.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    71. The evaluation of hepatic fibrosis scores in children with nonalcoholic fatty liver disease. Dig Dis Sci. 2015 May; 60(5):1440-7. PMID: 25540086.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    72. Circulating extracellular vesicles with specific proteome and liver microRNAs are potential biomarkers for liver injury in experimental fatty liver disease. PLoS One. 2014; 9(12):e113651. PMID: 25470250.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    73. Transient receptor potential vanilloid 1 gene deficiency ameliorates hepatic injury in a mouse model of chronic binge alcohol-induced alcoholic liver disease. Am J Pathol. 2015 Jan; 185(1):43-54. PMID: 25447051.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    74. Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis. PLoS One. 2014; 9(9):e107658. PMID: 25251155.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    75. Arginase 2 deficiency results in spontaneous steatohepatitis: a novel link between innate immune activation and hepatic de novo lipogenesis. J Hepatol. 2015 Feb; 62(2):412-20. PMID: 25234945.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    76. Adipocyte cell size, free fatty acids and apolipoproteins are associated with non-alcoholic liver injury progression in severely obese patients. Metabolism. 2014 Dec; 63(12):1542-52. PMID: 25267016.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    77. Adipocyte cell death, fatty liver disease and associated metabolic disorders. Dig Dis. 2014; 32(5):579-85. PMID: 25034291.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    78. NLRP3 inflammasome activation is required for fibrosis development in NAFLD. J Mol Med (Berl). 2014 Oct; 92(10):1069-82. PMID: 24861026.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimals
    79. Caspase 3 inactivation protects against hepatic cell death and ameliorates fibrogenesis in a diet-induced NASH model. Dig Dis Sci. 2014 Jun; 59(6):1197-206. PMID: 24795036.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    80. Letter: gender-associated cell-free microRNA profiles in non-alcoholic fatty liver disease--authors' reply. Aliment Pharmacol Ther. 2014 May; 39(9):999. PMID: 24689350.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    81. Leptin deficiency recapitulates the histological features of pulmonary arterial hypertension in mice. Int J Clin Exp Pathol. 2014; 7(5):1935-46. PMID: 24966903.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    82. Lipidomic profiling of bile in distinguishing benign from malignant biliary strictures: a single-blinded pilot study. Am J Gastroenterol. 2014 Jun; 109(6):895-902. PMID: 24710507.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
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    174. Bax inhibition protects against free fatty acid-induced lysosomal permeabilization. Am J Physiol Gastrointest Liver Physiol. 2006 Jun; 290(6):G1339-46. Feldstein AE, Werneburg NW, Li Z, Bronk SF, Gores GJ. PMID: 16484678.
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    175. Nonalcoholic fatty liver disease in the pediatric population: a review. Curr Opin Pediatr. 2005 Oct; 17(5):636-41. Wieckowska A, Feldstein AE. PMID: 16160540.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    176. Apoptosis in alcoholic and nonalcoholic steatohepatitis. Front Biosci. 2005 Sep 01; 10:3093-9. Feldstein AE, Gores GJ. PMID: 15970563.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    177. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology. 2005 Jul; 129(1):113-21. Adams LA, Lymp JF, St Sauver J, Sanderson SO, Lindor KD, Feldstein A, Angulo P. PMID: 16012941.
      View in: PubMed   Mentions: 784     Fields:    Translation:Humans
    178. Hepatic stellate cells and fibrosis progression in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2005 Apr; 3(4):384-9. Feldstein AE, Papouchado BG, Angulo P, Sanderson S, Adams L, Gores GJ. PMID: 15822044.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    179. Effect of lifestyle modifications on blood pressure by race, sex, hypertension status, and age. J Hum Hypertens. 2005 Jan; 19(1):21-31. Svetkey LP, Erlinger TP, Vollmer WM, Feldstein A, Cooper LS, Appel LJ, Ard JD, Elmer PJ, Harsha D, Stevens VJ. PMID: 15385946.
      View in: PubMed   Mentions:
    180. An apoptosis biomarker goes to the HCV clinic. Hepatology. 2004 Nov; 40(5):1044-6. Feldstein AE, Gores GJ. PMID: 15486920.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    181. Steatohepatitis and apoptosis: therapeutic implications. Am J Gastroenterol. 2004 Sep; 99(9):1718-9. Feldstein A, Gores GJ. PMID: 15330908.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    182. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology. 2004 Jul; 40(1):185-94. Feldstein AE, Werneburg NW, Canbay A, Guicciardi ME, Bronk SF, Rydzewski R, Burgart LJ, Gores GJ. PMID: 15239102.
      View in: PubMed   Mentions: 227     Fields:    Translation:HumansAnimalsCells
    183. Nonalcoholic fatty liver disease among patients with hypothalamic and pituitary dysfunction. Hepatology. 2004 Apr; 39(4):909-14. Adams LA, Feldstein A, Lindor KD, Angulo P. PMID: 15057893.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    184. Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice. J Hepatol. 2003 Dec; 39(6):978-83. Feldstein AE, Canbay A, Guicciardi ME, Higuchi H, Bronk SF, Gores GJ. PMID: 14642615.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    185. The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse. J Pharmacol Exp Ther. 2004 Mar; 308(3):1191-6. Canbay A, Feldstein A, Baskin-Bey E, Bronk SF, Gores GJ. PMID: 14617689.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    186. Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression. Hepatology. 2003 Nov; 38(5):1188-98. Canbay A, Feldstein AE, Higuchi H, Werneburg N, Grambihler A, Bronk SF, Gores GJ. PMID: 14578857.
      View in: PubMed   Mentions: 140     Fields:    Translation:AnimalsCells
    187. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology. 2003 Aug; 125(2):437-43. Feldstein AE, Canbay A, Angulo P, Taniai M, Burgart LJ, Lindor KD, Gores GJ. PMID: 12891546.
      View in: PubMed   Mentions: 301     Fields:    Translation:HumansCells
    188. Primary sclerosing cholangitis in children: a long-term follow-up study. Hepatology. 2003 Jul; 38(1):210-7. Feldstein AE, Perrault J, El-Youssif M, Lindor KD, Freese DK, Angulo P. PMID: 12830004.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    189. Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis. J Clin Invest. 2003 Jul; 112(2):152-9. Canbay A, Guicciardi ME, Higuchi H, Feldstein A, Bronk SF, Rydzewski R, Taniai M, Gores GJ. PMID: 12865404.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    190. Lipid-lowering-independent effects of simvastatin on the kidney in experimental hypercholesterolaemia. Nephrol Dial Transplant. 2003 Apr; 18(4):703-9. Wilson SH, Chade AR, Feldstein A, Sawamura T, Napoli C, Lerman A, Lerman LO. PMID: 12637638.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    191. Chronic intestinal pseudoobstruction associated with altered interstitial cells of cajal networks. J Pediatr Gastroenterol Nutr. 2003 Apr; 36(4):492-7. Feldstein AE, Miller SM, El-Youssef M, Rodeberg D, Lindor NM, Burgart LJ, Szurszewski JH, Farrugia G. PMID: 12658043.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    192. Prevalence and clinical significance of human herpesviruses 6 and 7 active infection in pediatric liver transplant patients. Pediatr Transplant. 2003 Apr; 7(2):125-9. Feldstein AE, Razonable RR, Boyce TG, Freese DK, El-Youssef M, Perrault J, Paya CV, Ishitani MB. PMID: 12654053.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    193. In vivo renal vascular and tubular function in experimental hypercholesterolemia. Hypertension. 1999 Oct; 34(4 Pt 2):859-64. Feldstein A, Krier JD, Sarafov MH, Lerman A, Best PJ, Wilson SH, Lerman LO. PMID: 10523374.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    194. New insights into the pathophysiology of renovascular hypertension. Mayo Clin Proc. 1997 Mar; 72(3):251-60. Romero JC, Feldstein AE, Rodriguez-Porcel MG, Cases-Amenos A. PMID: 9070202.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    195. The effect of ethanol on the in vivo conversion of 5-HTP-14C to serotonin-14C, 5-hydroxyindoleacetaldehyde-14C and its metabolites in rat brain. Int J Neuropharmacol. 1969 Jul; 8(4):347-51. Feldstein A, Sidel CM. PMID: 5307042.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
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