Ariel Feldstein

Title(s)Adjunct Professor, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
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    Hepatocyte-derived extracellular vesicles in alcoholic liver disease
    NIH R01AA028134Jul 1, 2020 - Mar 31, 2025
    Role: Principal Investigator
    Gain of function mutations in inflammasome related genes in human and experimental alcoholic liver disease
    NIH R01AA024206Sep 20, 2017 - Aug 31, 2022
    Role: Principal Investigator
    Gain of function mutations in inflammasome related genes in human and experimental alcoholic liver disease
    NIH U01AA024206Sep 20, 2017 - Aug 31, 2022
    Role: Principal Investigator
    Sterile inflammation and pyroptotic cell death in liver fibrosis
    NIH R01DK113592Mar 1, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Encapsulated RNAs in extracellular vesicles contribute ALD progression
    NIH R21AA023574Sep 5, 2015 - Aug 31, 2018
    Role: Principal Investigator
    Oxidized Metabolites of Linoleic Acid in Alcohol-induced Liver Injury
    NIH U01AA022489Sep 1, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Alcoholic liver disease: Biochemical, cellular and systemic responses to ethanol
    NIH P20AA017837Sep 30, 2009 - Aug 31, 2014
    Role: Co-Investigator
    Caspase Dependent Cell Death in Nonalcoholic Fatty Liver Disease
    NIH R01DK082451Aug 24, 2009 - Jun 30, 2013
    Role: Principal Investigator
    The Lysosomal-Mitochondrial Axis in Nonalcoholic Fatty Liver Disease
    NIH R01DK076852Mar 1, 2007 - Jan 31, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cell Death in Liver Disease and Liver Surgery. Biomedicines. 2024 Mar 01; 12(3). Stoess C, Choi YK, Onyuru J, Friess H, Hoffman HM, Hartmann D, Feldstein AE. PMID: 38540172; PMCID: PMC10968531.
      View in: PubMed   Mentions:
    2. NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis. EMBO Rep. 2024 Jan; 25(1):455. Kaufmann B, Leszczynska A, Reca A, Booshehri LM, Onyuru J, Tan Z, Wree A, Friess H, Hartmann D, Papouchado B, Broderick L, Hoffman HM, Croker BA, Zhu YP, Feldstein AE. PMID: 38216786; PMCID: PMC10897131.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. BRP39 Regulates Neutrophil Recruitment in NLRP3 Inflammasome-Induced Liver Inflammation. Cell Mol Gastroenterol Hepatol. 2024; 17(3):481-497. Kui L, Kim AD, Onyuru J, Hoffman HM, Feldstein AE. PMID: 38092312; PMCID: PMC10837621.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    4. Correction to: Myeloid‑specific deletion of chitinase‑3‑like 1 protein ameliorates murine diet‑induced steatohepatitis progression. J Mol Med (Berl). 2023 Dec; 101(12):1627. Kim AD, Kui L, Kaufmann B, Kim SE, Leszczynska A, Feldstein AE. PMID: 37953339; PMCID: PMC10697864.
      View in: PubMed   Mentions:    Fields:    
    5. Author Correction: JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders. Sci Rep. 2023 Nov 16; 13(1):20081. Ambrus-Aikelin G, Takeda K, Joetham A, Lazic M, Povero D, Santini AM, Pranadinata R, Johnson CD, McGeough MD, Beasley FC, Stansfield R, McBride C, Trzoss L, Hoffman HM, Feldstein AE, Stafford JA, Veal JM, Bain G, Gelfand EW. PMID: 37973811; PMCID: PMC10654444.
      View in: PubMed   Mentions:    Fields:    
    6. Extracellular Vesicles as Therapeutic and Diagnostic Tools for Chronic Liver Diseases. Biomedicines. 2023 Oct 17; 11(10). Leszczynska A, Stoess C, Sung H, Povero D, Eguchi A, Feldstein A. PMID: 37893181; PMCID: PMC10604241.
      View in: PubMed   Mentions:
    7. JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders. Sci Rep. 2023 08 19; 13(1):13524. Ambrus-Aikelin G, Takeda K, Joetham A, Lazic M, Povero D, Santini AM, Pranadinata R, Johnson CD, McGeough MD, Beasley FC, Stansfield R, McBride C, Trzoss L, Hoffman HM, Feldstein AE, Stafford JA, Veal JM, Bain G, Gelfand EW. PMID: 37598239; PMCID: PMC10439952.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    8. Pyroptosis and gasdermins-Emerging insights and therapeutic opportunities in metabolic dysfunction-associated steatohepatitis. Front Cell Dev Biol. 2023; 11:1218807. Stoess C, Leszczynska A, Kui L, Feldstein AE. PMID: 37664463; PMCID: PMC10470644.
      View in: PubMed   Mentions: 1  
    9. Antisense Oligonucleotide Therapy Decreases IL-1β Expression and Prolongs Survival in Mutant Nlrp3 Mice. J Immunol. 2023 07 15; 211(2):287-294. Kaufmann B, de Los Reyes Jiménez M, Booshehri LM, Onyuru J, Leszczynska A, Uri A, Michel S, Klar R, Jaschinski F, Feldstein AE, Broderick L, Hoffman HM. PMID: 37256266.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    10. Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis. J Pharmacol Exp Ther. 2023 08; 386(2):242-258. Povero D, Lazic M, McBride C, Ambrus-Aikelin G, Stansfield R, Johnson CD, Santini AM, Pranadinata RF, McGeough MD, Stafford JA, Hoffman HM, Feldstein AE, Veal JM, Bain G. PMID: 37308266.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    11. Myeloid-specific deletion of chitinase-3-like 1 protein ameliorates murine diet-induced steatohepatitis progression. J Mol Med (Berl). 2023 07; 101(7):813-828. Kim AD, Kui L, Kaufmann B, Kim SE, Leszczynska A, Feldstein AE. PMID: 37166517; PMCID: PMC10300183.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    12. Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH. Cell Rep. 2022 Nov 15; 41(7):111660. Daemen S, Gainullina A, Kalugotla G, He L, Chan MM, Beals JW, Liss KH, Klein S, Feldstein AE, Finck BN, Artyomov MN, Schilling JD. PMID: 36384118.
      View in: PubMed   Mentions: 2     Fields:    
    13. Interleukin-18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Hepatology. 2023 06 01; 77(6):1968-1982. Knorr J, Kaufmann B, Inzaugarat ME, Holtmann TM, Geisler L, Hundertmark J, Kohlhepp MS, Boosheri LM, Chilin-Fuentes DR, Birmingham A, Fisch KM, Schilling JD, Loosen SH, Trautwein C, Roderburg C, Demir M, Tacke F, Hoffman HM, Feldstein AE, Wree A. PMID: 36059147; PMCID: PMC9984672.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    14. NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis. EMBO Rep. 2022 11 07; 23(11):e54446. Kaufmann B, Leszczynska A, Reca A, Booshehri LM, Onyuru J, Tan Z, Wree A, Friess H, Hartmann D, Papouchado B, Broderick L, Hoffman HM, Croker BA, Zhu YP, Feldstein AE. PMID: 36194627; PMCID: PMC9638850.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    15. The role of oxidized lipid species in insulin resistance and NASH in children. Front Endocrinol (Lausanne). 2022; 13:1019204. Santoro N, Feldstein AE. PMID: 36263326; PMCID: PMC9573982.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. A WISP1 antibody inhibits MRTF signaling to prevent the progression of established liver fibrosis. Cell Metab. 2022 09 06; 34(9):1377-1393.e8. Xi Y, LaCanna R, Ma HY, N'Diaye EN, Gierke S, Caplazi P, Sagolla M, Huang Z, Lucio L, Arlantico A, Jeet S, Brightbill H, Emson C, Wong A, Morshead KB, DePianto DJ, Roose-Girma M, Yu C, Tam L, Jia G, Ramalingam TR, Marsters S, Ashkenazi A, Kim SH, Kelly R, Wu S, Wolters PJ, Feldstein AE, Vander Heiden JA, Ding N. PMID: 35987202.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    17. Cell-specific Deletion of NLRP3 Inflammasome Identifies Myeloid Cells as Key Drivers of Liver Inflammation and Fibrosis in Murine Steatohepatitis. Cell Mol Gastroenterol Hepatol. 2022; 14(4):751-767. Kaufmann B, Kui L, Reca A, Leszczynska A, Kim AD, Booshehri LM, Wree A, Friess H, Hartmann D, Broderick L, Hoffman HM, Feldstein AE. PMID: 35787975; PMCID: PMC9424559.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    18. A low n-6 to n-3 polyunsaturated fatty acid ratio diet improves hyperinsulinaemia by restoring insulin clearance in obese youth. Diabetes Obes Metab. 2022 07; 24(7):1267-1276. Tricò D, Galderisi A, Van Name MA, Caprio S, Samuels S, Li Z, Galuppo BT, Savoye M, Mari A, Feldstein AE, Santoro N. PMID: 35297549; PMCID: PMC9177628.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    19. NOD-like receptor protein 3 activation causes spontaneous inflammation and fibrosis that mimics human NASH. Hepatology. 2022 09; 76(3):727-741. Calcagno DM, Chu A, Gaul S, Taghdiri N, Toomu A, Leszczynska A, Kaufmann B, Papouchado B, Wree A, Geisler L, Hoffman HM, Feldstein AE, King KR. PMID: 34997987; PMCID: PMC10176600.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    20. Protein and miRNA profile of circulating extracellular vesicles in patients with primary sclerosing cholangitis. Sci Rep. 2022 02 22; 12(1):3027. Povero D, Tameda M, Eguchi A, Ren W, Kim J, Myers R, Goodman ZD, Harrison SA, Sanyal AJ, Bosch J, Ohno-Machado L, Feldstein AE. PMID: 35194091; PMCID: PMC8863778.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    21. Cell-to-Cell Communications in Alcohol-Associated Liver Disease. Front Physiol. 2022; 13:831004. Osna NA, Eguchi A, Feldstein AE, Tsukamoto H, Dagur RS, Ganesan M, New-Aaron M, Arumugam MK, Chava S, Ribeiro M, Szabo G, Mueller S, Wang S, Chen C, Weinman SA, Kharbanda KK. PMID: 35264978; PMCID: PMC8899290.
      View in: PubMed   Mentions: 8  
    22. Dual role of neutrophils in modulating liver injury and fibrosis during development and resolution of diet-induced murine steatohepatitis. Sci Rep. 2021 12 17; 11(1):24194. Kim AD, Kim SE, Leszczynska A, Kaufmann B, Reca A, Kim DJ, Feldstein AE. PMID: 34921208; PMCID: PMC8683497.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    23. Bile Acids Activate NLRP3 Inflammasome, Promoting Murine Liver Inflammation or Fibrosis in a Cell Type-Specific Manner. Cells. 2021 10 01; 10(10). Holtmann TM, Inzaugarat ME, Knorr J, Geisler L, Schulz M, Bieghs V, Frissen M, Feldstein AE, Tacke F, Trautwein C, Wree A. PMID: 34685598; PMCID: PMC8534222.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    24. Pyroptosis in Steatohepatitis and Liver Diseases. J Mol Biol. 2022 02 28; 434(4):167271. Knorr J, Wree A, Feldstein AE. PMID: 34592216.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    25. Insights into Nonalcoholic Fatty-Liver Disease Heterogeneity. Semin Liver Dis. 2021 11; 41(4):421-434. Arrese M, Arab JP, Barrera F, Kaufmann B, Valenti L, Feldstein AE. PMID: 34233370; PMCID: PMC8492194.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    26. Feeding mice a diet high in oxidized linoleic acid metabolites does not alter liver oxylipin concentrations. Prostaglandins Leukot Essent Fatty Acids. 2021 09; 172:102316. Liang N, Hennebelle M, Gaul S, Johnson CD, Zhang Z, Kirpich IA, McClain CJ, Feldstein AE, Ramsden CE, Taha AY. PMID: 34403987; PMCID: PMC9157566.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    27. Novel Mechanisms for Resolution of Liver Inflammation: Therapeutic Implications. Semin Liver Dis. 2021 05; 41(2):150-162. Kaufmann B, Reca A, Kim AD, Feldstein AE. PMID: 34107544.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    28. Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH. Cell Rep. 2021 01 12; 34(2):108626. Daemen S, Gainullina A, Kalugotla G, He L, Chan MM, Beals JW, Liss KH, Klein S, Feldstein AE, Finck BN, Artyomov MN, Schilling JD. PMID: 33440159; PMCID: PMC7877246.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    29. The Power of Single-Cell Analysis for the Study of Liver Pathobiology. Hepatology. 2021 01; 73(1):437-448. Chu AL, Schilling JD, King KR, Feldstein AE. PMID: 32740968; PMCID: PMC7854989.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    30. Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis. Gut. 2021 10; 70(10):1954-1964. Koh EH, Yoon JE, Ko MS, Leem J, Yun JY, Hong CH, Cho YK, Lee SE, Jang JE, Baek JY, Yoo HJ, Kim SJ, Sung CO, Lim JS, Jeong WI, Back SH, Baek IJ, Torres S, Solsona-Vilarrasa E, Conde de la Rosa L, Garcia-Ruiz C, Feldstein AE, Fernandez-Checa JC, Lee KU. PMID: 33208407; PMCID: PMC8458090.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    31. A Low ω-6 to ω-3 PUFA Ratio (n-6:n-3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth. J Nutr. 2020 09 01; 150(9):2314-2321. Van Name MA, Savoye M, Chick JM, Galuppo BT, Feldstein AE, Pierpont B, Johnson C, Shabanova V, Ekong U, Valentino PL, Kim G, Caprio S, Santoro N. PMID: 32652034; PMCID: PMC7467848.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCTClinical Trials
    32. Mechanisms of nonalcoholic fatty liver disease and implications for surgery. Langenbecks Arch Surg. 2021 Feb; 406(1):1-17. Kaufmann B, Reca A, Wang B, Friess H, Feldstein AE, Hartmann D. PMID: 32833053; PMCID: PMC7870612.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    33. Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis. J Hepatol. 2021 01; 74(1):156-167. Gaul S, Leszczynska A, Alegre F, Kaufmann B, Johnson CD, Adams LA, Wree A, Damm G, Seehofer D, Calvente CJ, Povero D, Kisseleva T, Eguchi A, McGeough MD, Hoffman HM, Pelegrin P, Laufs U, Feldstein AE. PMID: 32763266; PMCID: PMC7749849.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansAnimalsCells
    34. Characterization and Proteome of Circulating Extracellular Vesicles as Potential Biomarkers for NASH. Hepatol Commun. 2020 Sep; 4(9):1263-1278. Povero D, Yamashita H, Ren W, Subramanian MG, Myers RP, Eguchi A, Simonetto DA, Goodman ZD, Harrison SA, Sanyal AJ, Bosch J, Feldstein AE. PMID: 32923831; PMCID: PMC7471415.
      View in: PubMed   Mentions: 39     Fields:    
    35. Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1β and IL-17 upregulation in alcoholic hepatitis mice. J Mol Med (Berl). 2020 07; 98(7):1021-1034. Eguchi A, Yan R, Pan SQ, Wu R, Kim J, Chen Y, Ansong C, Smith RD, Tempaku M, Ohno-Machado L, Takei Y, Feldstein AE, Tsukamoto H. PMID: 32556367; PMCID: PMC7810220.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    36. The NLRP3 Inflammasome in Alcoholic and Nonalcoholic Steatohepatitis. Semin Liver Dis. 2020 Aug; 40(3):298-306. Knorr J, Wree A, Tacke F, Feldstein AE. PMID: 32526788.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    37. ASK1 inhibition reduces cell death and hepatic fibrosis in an Nlrp3 mutant liver injury model. JCI Insight. 2020 01 30; 5(2). Schuster-Gaul S, Geisler LJ, McGeough MD, Johnson CD, Zagorska A, Li L, Wree A, Barry V, Mikaelian I, Jih LJ, Papouchado BG, Budas G, Hoffman HM, Feldstein AE. PMID: 31996485; PMCID: PMC7098717.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    38. Identification of actin network proteins, talin-1 and filamin-A, in circulating extracellular vesicles as blood biomarkers for human myalgic encephalomyelitis/chronic fatigue syndrome. Brain Behav Immun. 2020 02; 84:106-114. Eguchi A, Fukuda S, Kuratsune H, Nojima J, Nakatomi Y, Watanabe Y, Feldstein AE. PMID: 31759091; PMCID: PMC7010541.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    39. Designing Clinical Trials in Pediatric Nonalcoholic Steatohepatitis: Tips for Patient Selection and Appropriate Endpoints. Hepatol Commun. 2019 Dec; 3(12):1563-1570. Alkhouri N, Kohli R, Feldstein AE. PMID: 31832567; PMCID: PMC6887671.
      View in: PubMed   Mentions: 6     Fields:    
    40. MicroRNA 223 3p Negatively Regulates the NLRP3 Inflammasome in Acute and Chronic Liver Injury. Mol Ther. 2020 02 05; 28(2):653-663. Jimenez Calvente C, Del Pilar H, Tameda M, Johnson CD, Feldstein AE. PMID: 31585800; PMCID: PMC7000998.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    41. Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223. J Clin Invest. 2019 07 11; 129(10):4091-4109. Calvente CJ, Tameda M, Johnson CD, Del Pilar H, Lin YC, Adronikou N, De Mollerat Du Jeu X, Llorente C, Boyer J, Feldstein AE. PMID: 31295147; PMCID: PMC6763256.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    42. NAFLD in children: new genes, new diagnostic modalities and new drugs. Nat Rev Gastroenterol Hepatol. 2019 09; 16(9):517-530. Nobili V, Alisi A, Valenti L, Miele L, Feldstein AE, Alkhouri N. PMID: 31278377.
      View in: PubMed   Mentions: 108     Fields:    Translation:Humans
    43. Human induced pluripotent stem cell-derived extracellular vesicles reduce hepatic stellate cell activation and liver fibrosis. JCI Insight. 2019 06 11; 5. Povero D, Pinatel EM, Leszczynska A, Goyal NP, Nishio T, Kim J, Kneiber D, de Araujo Horcel L, Eguchi A, Ordonez PM, Kisseleva T, Feldstein AE. PMID: 31184999; PMCID: PMC6675559.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    44. Novel Drivers of the Inflammatory Response in Liver Injury and Fibrosis. Semin Liver Dis. 2019 07; 39(3):275-282. Wree A, Holtmann TM, Inzaugarat ME, Feldstein AE. PMID: 31100758.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    45. Extracellular vesicles, the liquid biopsy of the future. J Hepatol. 2019 06; 70(6):1292-1294. Eguchi A, Kostallari E, Feldstein AE, Shah VH. PMID: 30982591; PMCID: PMC7094760.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    46. NLR Family Pyrin Domain-Containing 3 Inflammasome Activation in Hepatic Stellate Cells Induces Liver Fibrosis in Mice. Hepatology. 2019 02; 69(2):845-859. Inzaugarat ME, Johnson CD, Holtmann TM, McGeough MD, Trautwein C, Papouchado BG, Schwabe R, Hoffman HM, Wree A, Feldstein AE. PMID: 30180270; PMCID: PMC6351190.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    47. Extracellular Vesicles in Liver Diseases: Meeting Report from the International Liver Congress 2018. Hepatol Commun. 2019 Feb; 3(2):305-315. Banales JM, Feldstein AE, Sänger H, Lukacs-Kornek V, Szabo G, Kornek M. PMID: 30766966; PMCID: PMC6357829.
      View in: PubMed   Mentions: 8     Fields:    
    48. Non-alcoholic fatty liver disease in pediatric type 2 diabetes: Metabolic and histologic characteristics in 38 subjects. Pediatr Diabetes. 2019 02; 20(1):41-47. Newfield RS, Graves CL, Newbury RO, Schwimmer JB, Proudfoot JA, Say DS, Feldstein AE. PMID: 30467936.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    49. Differential Activation of Hepatic Invariant NKT Cell Subsets Plays a Key Role in Progression of Nonalcoholic Steatohepatitis. J Immunol. 2018 11 15; 201(10):3017-3035. Maricic I, Marrero I, Eguchi A, Nakamura R, Johnson CD, Dasgupta S, Hernandez CD, Nguyen PS, Swafford AD, Knight R, Feldstein AE, Loomba R, Kumar V. PMID: 30322964; PMCID: PMC6219905.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    50. Correction: Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein levels predict the presence of fibrotic nonalcoholic steatohepatitis (NASH) and NASH cirrhosis. PLoS One. 2018; 13(10):e0205541. Alkhouri N, Johnson C, Adams L, Kitajima S, Tsuruno C, Colpitts TL, Hatcho K, Lawitz E, Lopez R, Feldstein AE. PMID: 30286196; PMCID: PMC6171937.
      View in: PubMed   Mentions: 1     Fields:    
    51. Ethanol and unsaturated dietary fat induce unique patterns of hepatic ω-6 and ω-3 PUFA oxylipins in a mouse model of alcoholic liver disease. PLoS One. 2018; 13(9):e0204119. Warner DR, Liu H, Ghosh Dastidar S, Warner JB, Prodhan MAI, Yin X, Zhang X, Feldstein AE, Gao B, Prough RA, McClain CJ, Kirpich IA. PMID: 30256818; PMCID: PMC6157879.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    52. Complex Network of NKT Cell Subsets Controls Immune Homeostasis in Liver and Gut. Front Immunol. 2018; 9:2082. Marrero I, Maricic I, Feldstein AE, Loomba R, Schnabl B, Rivera-Nieves J, Eckmann L, Kumar V. PMID: 30254647; PMCID: PMC6141878.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    53. Liquid biopsy for liver diseases. Gut. 2018 12; 67(12):2204-2212. Mann J, Reeves HL, Feldstein AE. PMID: 30177542.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    54. Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein levels predict the presence of fibrotic nonalcoholic steatohepatitis (NASH) and NASH cirrhosis. PLoS One. 2018; 13(8):e0202226. Alkhouri N, Johnson C, Adams L, Kitajima S, Tsuruno C, Colpitts TL, Hatcho K, Lawitz E, Lopez R, Feldstein AE. PMID: 30161179; PMCID: PMC6116978.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    55. Effects of diets enriched in linoleic acid and its peroxidation products on brain fatty acids, oxylipins, and aldehydes in mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 10; 1863(10):1206-1213. Ramsden CE, Hennebelle M, Schuster S, Keyes GS, Johnson CD, Kirpich IA, Dahlen JE, Horowitz MS, Zamora D, Feldstein AE, McClain CJ, Muhlhausler BS, Makrides M, Gibson RA, Taha AY. PMID: 30053599; PMCID: PMC6180905.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    56. Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice. J Lipid Res. 2018 09; 59(9):1597-1609. Schuster S, Johnson CD, Hennebelle M, Holtmann T, Taha AY, Kirpich IA, Eguchi A, Ramsden CE, Papouchado BG, McClain CJ, Feldstein AE. PMID: 30084831; PMCID: PMC6121934.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    57. Triggering and resolution of inflammation in NASH. Nat Rev Gastroenterol Hepatol. 2018 06; 15(6):349-364. Schuster S, Cabrera D, Arrese M, Feldstein AE. PMID: 29740166.
      View in: PubMed   Mentions: 291     Fields:    Translation:Humans
    58. Emricasan, a pan-caspase inhibitor, improves survival and portal hypertension in a murine model of common bile-duct ligation. J Mol Med (Berl). 2018 06; 96(6):575-583. Eguchi A, Koyama Y, Wree A, Johnson CD, Nakamura R, Povero D, Kneiber D, Tameda M, Contreras P, Spada A, Feldstein AE. PMID: 29728708; PMCID: PMC6347405.
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    59. Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress. Biomolecules. 2018 03 26; 8(2). Kharbanda KK, Ronis MJJ, Shearn CT, Petersen DR, Zakhari S, Warner DR, Feldstein AE, McClain CJ, Kirpich IA. PMID: 29587455; PMCID: PMC6022870.
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    60. Extracellular vesicles in non-alcoholic and alcoholic fatty liver diseases. Liver Res. 2018 Mar; 2(1):30-34. Eguchi A, Feldstein AE. PMID: 30345152; PMCID: PMC6190912.
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    61. Transmembrane BAX Inhibitor motif-containing 1, a novel anti-inflammatory approach for nonalcoholic steatohepatitis treatment. Hepatology. 2018 01; 67(1):438-441. Wree A, Inzaugarat ME, Feldstein AE. PMID: 28859227; PMCID: PMC5770148.
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    62. NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL-17 and TNF in mice. Hepatology. 2018 02; 67(2):736-749. Wree A, McGeough MD, Inzaugarat ME, Eguchi A, Schuster S, Johnson CD, Peña CA, Geisler LJ, Papouchado BG, Hoffman HM, Feldstein AE. PMID: 28902427; PMCID: PMC5849484.
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    63. TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies. J Clin Invest. 2017 12 01; 127(12):4488-4497. McGeough MD, Wree A, Inzaugarat ME, Haimovich A, Johnson CD, Peña CA, Goldbach-Mansky R, Broderick L, Feldstein AE, Hoffman HM. PMID: 29130929; PMCID: PMC5707143.
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    64. Dietary Linoleic Acid and Its Oxidized Metabolites Exacerbate Liver Injury Caused by Ethanol via Induction of Hepatic Proinflammatory Response in Mice. Am J Pathol. 2017 Oct; 187(10):2232-2245. Warner DR, Liu H, Miller ME, Ramsden CE, Gao B, Feldstein AE, Schuster S, McClain CJ, Kirpich IA. PMID: 28923202; PMCID: PMC5808136.
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    65. Traffic-related air pollution associations with cytokeratin-18, a marker of hepatocellular apoptosis, in an overweight and obese paediatric population. Pediatr Obes. 2018 06; 13(6):342-347. Hsieh S, Leaderer BP, Feldstein AE, Santoro N, McKay LA, Caprio S, McConnell R. PMID: 28730729; PMCID: PMC5775922.
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    66. Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis. Sci Rep. 2017 06 14; 7(1):3491. Cabrera D, Wree A, Povero D, Solís N, Hernandez A, Pizarro M, Moshage H, Torres J, Feldstein AE, Cabello-Verrugio C, Brandan E, Barrera F, Arab JP, Arrese M. PMID: 28615649; PMCID: PMC5471224.
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    67. Inflammasomes in Liver Fibrosis. Semin Liver Dis. 2017 05; 37(2):119-127. Alegre F, Pelegrin P, Feldstein AE. PMID: 28564720.
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    68. Oxidized Derivatives of Linoleic Acid in Pediatric Metabolic Syndrome: Is Their Pathogenic Role Modulated by the Genetic Background and the Gut Microbiota? Antioxid Redox Signal. 2019 01 10; 30(2):241-250. Tricò D, Di Sessa A, Caprio S, Chalasani N, Liu W, Liang T, Graf J, Herzog RI, Johnson CD, Umano GR, Feldstein AE, Santoro N. PMID: 28279074; PMCID: PMC6277079.
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    69. NASH-RELATED CIRRHOSIS: AN OCCULT LIVER DISEASE BURDEN. Hepatol Commun. 2017 Apr; 1(2):84-86. Arrese M, Feldstein AE. PMID: 29335681; PMCID: PMC5721433.
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    70. NASH: Novel therapeutic strategies targeting ASK1 in NASH. Nat Rev Gastroenterol Hepatol. 2017 06; 14(6):329-330. Schuster S, Feldstein AE. PMID: 28377639.
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    71. Treating nonalcoholic steatohepatitis in children: Not a cinch task. Hepatology. 2017 04; 65(4):1407-1409. Alkhouri N, Feldstein AE. PMID: 28073147.
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    72. Microvesicles released from fat-laden cells promote activation of hepatocellular NLRP3 inflammasome: A pro-inflammatory link between lipotoxicity and non-alcoholic steatohepatitis. PLoS One. 2017; 12(3):e0172575. Cannito S, Morello E, Bocca C, Foglia B, Benetti E, Novo E, Chiazza F, Rogazzo M, Fantozzi R, Povero D, Sutti S, Bugianesi E, Feldstein AE, Albano E, Collino M, Parola M. PMID: 28249038; PMCID: PMC5331985.
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    73. Update on lipid species and paediatric nonalcoholic fatty liver disease. Curr Opin Clin Nutr Metab Care. 2017 03; 20(2):110-116. Mann JP, Feldstein AE, Nobili V. PMID: 27906700.
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    74. NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. J Hepatol. 2017 05; 66(5):1037-1046. Mridha AR, Wree A, Robertson AAB, Yeh MM, Johnson CD, Van Rooyen DM, Haczeyni F, Teoh NC, Savard C, Ioannou GN, Masters SL, Schroder K, Cooper MA, Feldstein AE, Farrell GC. PMID: 28167322; PMCID: PMC6536116.
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    75. Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood. Hepatology. 2017 02; 65(2):475-490. Eguchi A, Lazaro RG, Wang J, Kim J, Povero D, Willliams B, Ho SB, Stärkel P, Schnabl B, Ohno-Machado L, Tsukamoto H, Feldstein AE. PMID: 27639178; PMCID: PMC5407075.
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    76. Fatty liver in adolescents: Mechanisms, clinical features and therapy. J Hepatol. 2016 12; 65(6):1258-1260. Nobili V, Feldstein AE. PMID: 27742132.
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    77. Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress. J Mol Med (Berl). 2016 11; 94(11):1241-1253. Eguchi A, Lazic M, Armando AM, Phillips SA, Katebian R, Maraka S, Quehenberger O, Sears DD, Feldstein AE. PMID: 27394413; PMCID: PMC5071132.
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    78. Hepatocyte mitochondrial DNA released in microparticles and toll-like receptor 9 activation: A link between lipotoxicity and inflammation during nonalcoholic steatohepatitis. Hepatology. 2016 08; 64(2):669-71. Inzaugarat ME, Wree A, Feldstein AE. PMID: 27239763; PMCID: PMC4956555.
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    79. Soluble IgM links apoptosis to complement activation in early alcoholic liver disease in mice. Mol Immunol. 2016 Apr; 72:9-18. Smathers RL, Chiang DJ, McMullen MR, Feldstein AE, Roychowdhury S, Nagy LE. PMID: 26922040; PMCID: PMC4828291.
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    80. Targeting Cell Death and Sterile Inflammation Loop for the Treatment of Nonalcoholic Steatohepatitis. Semin Liver Dis. 2016 Feb; 36(1):27-36. Wree A, Mehal WZ, Feldstein AE. PMID: 26870930; PMCID: PMC4955833.
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    81. Innate Immunity and Inflammation in NAFLD/NASH. Dig Dis Sci. 2016 May; 61(5):1294-303. Arrese M, Cabrera D, Kalergis AM, Feldstein AE. PMID: 26841783; PMCID: PMC4948286.
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    82. Noninvasive diagnosis of nonalcoholic fatty liver disease: Are we there yet? Metabolism. 2016 Aug; 65(8):1087-95. Alkhouri N, Feldstein AE. PMID: 26972222; PMCID: PMC4931968.
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    83. Novel Molecular Mechanisms in the Development of Non-Alcoholic Steatohepatitis. Diabetes Metab J. 2016 Feb; 40(1):1-11. Povero D, Feldstein AE. PMID: 26912150; PMCID: PMC4768045.
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    84. Similarities and differences between pediatric and adult nonalcoholic fatty liver disease. Metabolism. 2016 Aug; 65(8):1161-71. Crespo M, Lappe S, Feldstein AE, Alkhouri N. PMID: 26961580.
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    85. Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study. Hepatology. 2016 Jan; 63(1):117-25. Goffredo M, Caprio S, Feldstein AE, D'Adamo E, Shaw MM, Pierpont B, Savoye M, Zhao H, Bale AE, Santoro N. PMID: 26457389; PMCID: PMC4688225.
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    86. Liver Bid suppression for treatment of fibrosis associated with non-alcoholic steatohepatitis. J Hepatol. 2016 Mar; 64(3):699-707. Eguchi A, De Mollerat Du Jeu X, Johnson CD, Nektaria A, Feldstein AE. PMID: 26555271; PMCID: PMC4761314.
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    87. Lipid-induced hepatocyte-derived extracellular vesicles regulate hepatic stellate cell via microRNAs targeting PPAR-γ. Cell Mol Gastroenterol Hepatol. 2015 Nov 01; 1(6):646-663.e4. Povero D, Panera N, Eguchi A, Johnson CD, Papouchado BG, de Araujo Horcel L, Pinatel EM, Alisi A, Nobili V, Feldstein AE. PMID: 26783552; PMCID: PMC4714359.
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    88. Etiology, outcome and prognostic factors of childhood acute liver failure in a German Single Center. Ann Hepatol. 2015 Sep-Oct; 14(5):722-8. Kathemann S, Bechmann LP, Sowa JP, Manka P, Dechêne A, Gerner P, Lainka E, Hoyer PF, Feldstein AE, Canbay A. PMID: 26256901.
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    89. Burden of nonalcoholic fatty liver disease and advanced fibrosis in a Texas Hispanic community cohort. World J Hepatol. 2015 Jun 18; 7(11):1586-94. Pan JJ, Fisher-Hoch SP, Chen C, Feldstein AE, McCormick JB, Rahbar MH, Beretta L, Fallon MB. PMID: 26085918; PMCID: PMC4462697.
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    90. Redox nanoparticles as a novel treatment approach for inflammation and fibrosis associated with nonalcoholic steatohepatitis. Nanomedicine (Lond). 2015; 10(17):2697-708. Eguchi A, Yoshitomi T, Lazic M, Johnson CD, Vong LB, Wree A, Povero D, Papouchado BG, Nagasaki Y, Feldstein AE. PMID: 26020857; PMCID: PMC4910954.
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    91. Serum cytokeratin-18 fragment levels predict development of type 2 diabetes mellitus in adult patients with NAFLD. Liver Int. 2015 Dec; 35(12):2621. Nagpal SJ, Lopez R, Feldstein AE, Alkhouri N. PMID: 25939859.
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    92. Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation. Cell Death Differ. 2015 Dec; 22(12):1985-94. Wree A, Johnson CD, Font-Burgada J, Eguchi A, Povero D, Karin M, Feldstein AE. PMID: 25909884; PMCID: PMC4816107.
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    93. Microparticles release by adipocytes act as "find-me" signals to promote macrophage migration. PLoS One. 2015; 10(4):e0123110. Eguchi A, Mulya A, Lazic M, Radhakrishnan D, Berk MP, Povero D, Gornicka A, Feldstein AE. PMID: 25849214; PMCID: PMC4388837.
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    94. Circulating Soluble Fas and Fas Ligand Levels Are Elevated in Children with Nonalcoholic Steatohepatitis. Dig Dis Sci. 2015 Aug; 60(8):2353-9. Alkhouri N, Alisi A, Okwu V, Matloob A, Ferrari F, Crudele A, De Vito R, Lopez R, Feldstein AE, Nobili V. PMID: 25764498.
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    95. Beneficial effects of mineralocorticoid receptor blockade in experimental non-alcoholic steatohepatitis. Liver Int. 2015 Sep; 35(9):2129-38. Pizarro M, Solís N, Quintero P, Barrera F, Cabrera D, Rojas-de Santiago P, Arab JP, Padilla O, Roa JC, Moshage H, Wree A, Inzaugarat E, Feldstein AE, Fardella CE, Baudrand R, Riquelme A, Arrese M. PMID: 25646700; PMCID: PMC4522413.
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    96. Endoscopic treatment of pediatric post-transplant biliary complications is safe and effective. Dig Endosc. 2015 May; 27(4):505-511. Dechêne A, Kodde C, Kathemann S, Treckmann J, Lainka E, Paul A, Gerken G, Feldstein AE, Hoyer PF, Canbay A. PMID: 25545826.
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    97. Circulating microRNAs: emerging biomarkers of liver disease. Semin Liver Dis. 2015 Feb; 35(1):43-54. Arrese M, Eguchi A, Feldstein AE. PMID: 25632934.
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    98. The evaluation of hepatic fibrosis scores in children with nonalcoholic fatty liver disease. Dig Dis Sci. 2015 May; 60(5):1440-7. Mansoor S, Yerian L, Kohli R, Xanthakos S, Angulo P, Ling S, Lopez R, Christine CK, Feldstein AE, Alkhouri N. PMID: 25540086.
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    99. Circulating extracellular vesicles with specific proteome and liver microRNAs are potential biomarkers for liver injury in experimental fatty liver disease. PLoS One. 2014; 9(12):e113651. Povero D, Eguchi A, Li H, Johnson CD, Papouchado BG, Wree A, Messer K, Feldstein AE. PMID: 25470250; PMCID: PMC4254757.
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    100. Transient receptor potential vanilloid 1 gene deficiency ameliorates hepatic injury in a mouse model of chronic binge alcohol-induced alcoholic liver disease. Am J Pathol. 2015 Jan; 185(1):43-54. Liu H, Beier JI, Arteel GE, Ramsden CE, Feldstein AE, McClain CJ, Kirpich IA. PMID: 25447051; PMCID: PMC4278357.
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    101. Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis. PLoS One. 2014; 9(9):e107658. Lazic M, Inzaugarat ME, Povero D, Zhao IC, Chen M, Nalbandian M, Miller YI, Cherñavsky AC, Feldstein AE, Sears DD. PMID: 25251155; PMCID: PMC4175074.
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    102. Arginase 2 deficiency results in spontaneous steatohepatitis: a novel link between innate immune activation and hepatic de novo lipogenesis. J Hepatol. 2015 Feb; 62(2):412-20. Navarro LA, Wree A, Povero D, Berk MP, Eguchi A, Ghosh S, Papouchado BG, Erzurum SC, Feldstein AE. PMID: 25234945; PMCID: PMC4736721.
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    103. Adipocyte cell size, free fatty acids and apolipoproteins are associated with non-alcoholic liver injury progression in severely obese patients. Metabolism. 2014 Dec; 63(12):1542-52. Wree A, Schlattjan M, Bechmann LP, Claudel T, Sowa JP, Stojakovic T, Scharnagl H, Köfeler H, Baba HA, Gerken G, Feldstein AE, Trauner M, Canbay A. PMID: 25267016.
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    104. Adipocyte cell death, fatty liver disease and associated metabolic disorders. Dig Dis. 2014; 32(5):579-85. Eguchi A, Feldstein AE. PMID: 25034291; PMCID: PMC4512744.
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    105. NLRP3 inflammasome activation is required for fibrosis development in NAFLD. J Mol Med (Berl). 2014 Oct; 92(10):1069-82. Wree A, McGeough MD, Peña CA, Schlattjan M, Li H, Inzaugarat ME, Messer K, Canbay A, Hoffman HM, Feldstein AE. PMID: 24861026; PMCID: PMC4349416.
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    106. Caspase 3 inactivation protects against hepatic cell death and ameliorates fibrogenesis in a diet-induced NASH model. Dig Dis Sci. 2014 Jun; 59(6):1197-206. Thapaliya S, Wree A, Povero D, Inzaugarat ME, Berk M, Dixon L, Papouchado BG, Feldstein AE. PMID: 24795036; PMCID: PMC4512760.
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    107. Letter: gender-associated cell-free microRNA profiles in non-alcoholic fatty liver disease--authors' reply. Aliment Pharmacol Ther. 2014 May; 39(9):999. Newton KP, Awai HI, Feldstein AE, Schwimmer JB. PMID: 24689350.
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    108. Leptin deficiency recapitulates the histological features of pulmonary arterial hypertension in mice. Int J Clin Exp Pathol. 2014; 7(5):1935-46. Aytekin M, Tonelli AR, Farver CF, Feldstein AE, Dweik RA. PMID: 24966903; PMCID: PMC4069962.
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    109. Lipidomic profiling of bile in distinguishing benign from malignant biliary strictures: a single-blinded pilot study. Am J Gastroenterol. 2014 Jun; 109(6):895-902. Navaneethan U, Gutierrez NG, Venkatesh PG, Jegadeesan R, Zhang R, Jang S, Sanaka MR, Vargo JJ, Parsi MA, Feldstein AE, Stevens T. PMID: 24710507.
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    110. Differential regulation of inflammation and apoptosis in Fas-resistant hepatocyte-specific Bid-deficient mice. J Hepatol. 2014 Jul; 61(1):107-15. Lazic M, Eguchi A, Berk MP, Povero D, Papouchado B, Mulya A, Johnson CD, Feldstein AE. PMID: 24681344; PMCID: PMC4712949.
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    111. [Cytokeratin 18 as marker for non-invasive diagnosis and prognosis of acute and chronic liver diseases]. Z Gastroenterol. 2014 Mar; 52(3):290-5. Canbay A, Feldstein A, Kronenberger B, Schulze-Osthoff K, Bantel H. PMID: 24622872.
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    112. Obesity, nutrition, and liver disease in children. Clin Liver Dis. 2014 Feb; 18(1):219-31. Feldstein AE, Patton-Ku D, Boutelle KN. PMID: 24274876; PMCID: PMC4008146.
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    113. NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice. Hepatology. 2014 Mar; 59(3):898-910. Wree A, Eguchi A, McGeough MD, Pena CA, Johnson CD, Canbay A, Hoffman HM, Feldstein AE. PMID: 23813842; PMCID: PMC4008151.
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    114. OxNASH score correlates with histologic features and severity of nonalcoholic fatty liver disease. Dig Dis Sci. 2014 Jul; 59(7):1617-24. Alkhouri N, Berk M, Yerian L, Lopez R, Chung YM, Zhang R, McIntyre TM, Feldstein AE, Hazen SL. PMID: 24464211; PMCID: PMC4279921.
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    115. Biomarkers of liver cell death. J Hepatol. 2014 May; 60(5):1063-74. Eguchi A, Wree A, Feldstein AE. PMID: 24412608.
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    116. Dipeptidyl peptidase IV inhibitor lowers PPARγ agonist-induced body weight gain by affecting food intake, fat mass, and beige/brown fat but not fluid retention. Am J Physiol Endocrinol Metab. 2014 Feb 15; 306(4):E388-98. Masuda T, Fu Y, Eguchi A, Czogalla J, Rose MA, Kuczkowski A, Gerasimova M, Feldstein AE, Scadeng M, Vallon V. PMID: 24347054; PMCID: PMC3923087.
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    117. Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal Controls. Gastroenterol Res Pract. 2013; 2013:498296. Patel NS, Peterson MR, Lin GY, Feldstein A, Schnabl B, Bettencourt R, Seki E, Sirlin CB, Loomba R. PMID: 24348536; PMCID: PMC3855930.
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    118. Lipid-induced toxicity stimulates hepatocytes to release angiogenic microparticles that require Vanin-1 for uptake by endothelial cells. Sci Signal. 2013 Oct 08; 6(296):ra88. Povero D, Eguchi A, Niesman IR, Andronikou N, de Mollerat du Jeu X, Mulya A, Berk M, Lazic M, Thapaliya S, Parola M, Patel HH, Feldstein AE. PMID: 24106341; PMCID: PMC4016801.
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    119. Health-related quality of life in children with autoimmune liver disease. J Pediatr Gastroenterol Nutr. 2013 Oct; 57(4):444-50. Gulati R, Radhakrishnan KR, Hupertz V, Wyllie R, Alkhouri N, Worley S, Feldstein AE. PMID: 23783017.
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    120. From NAFLD to NASH to cirrhosis-new insights into disease mechanisms. Nat Rev Gastroenterol Hepatol. 2013 Nov; 10(11):627-36. Wree A, Broderick L, Canbay A, Hoffman HM, Feldstein AE. PMID: 23958599.
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    121. Limited value of plasma cytokeratin-18 as a biomarker for NASH and fibrosis in patients with non-alcoholic fatty liver disease. J Hepatol. 2014 Jan; 60(1):167-74. Cusi K, Chang Z, Harrison S, Lomonaco R, Bril F, Orsak B, Ortiz-Lopez C, Hecht J, Feldstein AE, Webb A, Louden C, Goros M, Tio F. PMID: 23973932.
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    122. Oxidized fatty acids: A potential pathogenic link between fatty liver and type 2 diabetes in obese adolescents? Antioxid Redox Signal. 2014 Jan 10; 20(2):383-9. Santoro N, Caprio S, Giannini C, Kim G, Kursawe R, Pierpont B, Shaw MM, Feldstein AE. PMID: 23815500; PMCID: PMC3887421.
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    123. Oxidized metabolites of linoleic acid as biomarkers of liver injury in nonalcoholic steatohepatitis. Clin Lipidol. 2013 Aug 01; 8(4):411-418. Santoro N, Caprio S, Feldstein AE. PMID: 26405460; PMCID: PMC4578804.
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    124. Stearoyl-CoA desaturase plays an important role in proliferation and chemoresistance in human hepatocellular carcinoma. J Surg Res. 2014 Jan; 186(1):29-38. Bansal S, Berk M, Alkhouri N, Partrick DA, Fung JJ, Feldstein A. PMID: 24135379; PMCID: PMC3923502.
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    125. Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial. Pain. 2013 Nov; 154(11):2441-2451. Ramsden CE, Faurot KR, Zamora D, Suchindran CM, MacIntosh BA, Gaylord S, Ringel A, Hibbeln JR, Feldstein AE, Mori TA, Barden A, Lynch C, Coble R, Mas E, Palsson O, Barrow DA, Mann DJ. PMID: 23886520; PMCID: PMC3850757.
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    126. Serum bilirubin level is inversely associated with nonalcoholic steatohepatitis in children. J Pediatr Gastroenterol Nutr. 2013 Jul; 57(1):114-8. Puri K, Nobili V, Melville K, Corte CD, Sartorelli MR, Lopez R, Feldstein AE, Alkhouri N. PMID: 23518490.
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    127. Mice lacking C1q are protected from high fat diet-induced hepatic insulin resistance and impaired glucose homeostasis. J Biol Chem. 2013 Aug 02; 288(31):22565-75. Hillian AD, McMullen MR, Sebastian BM, Roychowdhury S, Rowchowdhury S, Kashyap SR, Schauer PR, Kirwan JP, Feldstein AE, Nagy LE. PMID: 23788643; PMCID: PMC3829343.
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    128. Serum cytokeratin-18 fragment levels are useful biomarkers for nonalcoholic steatohepatitis in children. Am J Gastroenterol. 2013 Sep; 108(9):1526-31. Feldstein AE, Alkhouri N, De Vito R, Alisi A, Lopez R, Nobili V. PMID: 23752877.
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    129. Circulating levels of FGF-21 in obese youth: associations with liver fat content and markers of liver damage. J Clin Endocrinol Metab. 2013 Jul; 98(7):2993-3000. Giannini C, Feldstein AE, Santoro N, Kim G, Kursawe R, Pierpont B, Caprio S. PMID: 23626003; PMCID: PMC3701279.
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    130. Novel therapeutic targets for nonalcoholic fatty liver disease. Expert Opin Ther Targets. 2013 Jul; 17(7):773-9. Eguchi A, Povero D, Alkhouri N, Feldstein AE. PMID: 23600493.
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    131. Lysosomal Cathepsin D contributes to cell death during adipocyte hypertrophy. Adipocyte. 2013 Jul 01; 2(3):170-5. Eguchi A, Feldstein AE. PMID: 23991364; PMCID: PMC3756106.
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    132. Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis. PLoS One. 2013; 8(2):e56100. Dixon LJ, Flask CA, Papouchado BG, Feldstein AE, Nagy LE. PMID: 23409132; PMCID: PMC3567081.
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    133. The association between hepatic fat content and liver injury in obese children and adolescents: effects of ethnicity, insulin resistance, and common gene variants. Diabetes Care. 2013 May; 36(5):1353-60. Santoro N, Feldstein AE, Enoksson E, Pierpont B, Kursawe R, Kim G, Caprio S. PMID: 23275357; PMCID: PMC3631865.
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    134. Combined paediatric NAFLD fibrosis index and transient elastography to predict clinically significant fibrosis in children with fatty liver disease. Liver Int. 2013 Jan; 33(1):79-85. Alkhouri N, Sedki E, Alisi A, Lopez R, Pinzani M, Feldstein AE, Nobili V. PMID: 23146095.
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    135. Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism. Hepatology. 2012 Oct; 56(4):1291-9. Zein CO, Lopez R, Fu X, Kirwan JP, Yerian LM, McCullough AJ, Hazen SL, Feldstein AE. PMID: 22505276; PMCID: PMC3430813.
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    136. Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. Prostaglandins Leukot Essent Fatty Acids. 2012 Oct-Nov; 87(4-5):135-41. Ramsden CE, Ringel A, Feldstein AE, Taha AY, MacIntosh BA, Hibbeln JR, Majchrzak-Hong SF, Faurot KR, Rapoport SI, Cheon Y, Chung YM, Berk M, Mann JD. PMID: 22959954; PMCID: PMC3467319.
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    137. Longitudinal effects of MRI-measured hepatic steatosis on biomarkers of glucose homeostasis and hepatic apoptosis in obese youth. Diabetes Care. 2013 Jan; 36(1):130-6. Kim G, Giannini C, Pierpont B, Feldstein AE, Santoro N, Kursawe R, Shaw M, Duran E, Goldberg R, Dziura J, Caprio S. PMID: 22933439; PMCID: PMC3526202.
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    138. Development and validation of a new histological score for pediatric non-alcoholic fatty liver disease. J Hepatol. 2012 Dec; 57(6):1312-8. Alkhouri N, De Vito R, Alisi A, Yerian L, Lopez R, Feldstein AE, Nobili V. PMID: 22871498.
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    139. Adipocyte hypertrophy is associated with lysosomal permeability both in vivo and in vitro: role in adipose tissue inflammation. Am J Physiol Endocrinol Metab. 2012 Sep 01; 303(5):E597-606. Gornicka A, Fettig J, Eguchi A, Berk MP, Thapaliya S, Dixon LJ, Feldstein AE. PMID: 22739104; PMCID: PMC3468510.
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    140. Lipidomic profiling of serum and pancreatic fluid in chronic pancreatitis. Pancreas. 2012 May; 41(4):518-22. Stevens T, Berk MP, Lopez R, Chung YM, Zhang R, Parsi MA, Bronner MP, Feldstein AE. PMID: 22504378.
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    141. Markers of activated inflammatory cells correlate with severity of liver damage in children with nonalcoholic fatty liver disease. Int J Mol Med. 2012 Jul; 30(1):49-56. De Vito R, Alisi A, Masotti A, Ceccarelli S, Panera N, Citti A, Salata M, Valenti L, Feldstein AE, Nobili V. PMID: 22505182.
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    142. Leptin levels predict survival in pulmonary arterial hypertension. Pulm Circ. 2012 Apr-Jun; 2(2):214-9. Tonelli AR, Aytekin M, Feldstein AE, Dweik RA. PMID: 22837862; PMCID: PMC3401875.
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    143. The TONIC trial: a step forward in treating pediatric nonalcoholic fatty liver disease. Hepatology. 2012 Apr; 55(4):1292-5. Alkhouri N, Feldstein AE. PMID: 22461076; PMCID: PMC3325147.
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    144. Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis. Lab Invest. 2012 May; 92(5):713-23. Dixon LJ, Berk M, Thapaliya S, Papouchado BG, Feldstein AE. PMID: 22411067; PMCID: PMC3808241.
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    145. Inhibition of apoptosis protects mice from ethanol-mediated acceleration of early markers of CCl4 -induced fibrosis but not steatosis or inflammation. Alcohol Clin Exp Res. 2012 Jul; 36(7):1139-47. Roychowdhury S, Chiang DJ, Mandal P, McMullen MR, Liu X, Cohen JI, Pollard J, Feldstein AE, Nagy LE. PMID: 22273278; PMCID: PMC3337974.
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    146. Pediatric nonalcoholic fatty liver disease: a multidisciplinary approach. Nat Rev Gastroenterol Hepatol. 2012 Jan 17; 9(3):152-61. Alisi A, Feldstein AE, Villani A, Raponi M, Nobili V. PMID: 22249728.
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    147. Mean platelet volume as a marker of increased cardiovascular risk in patients with nonalcoholic steatohepatitis. Hepatology. 2012 Jan; 55(1):331. Alkhouri N, Kistangari G, Campbell C, Lopez R, Zein NN, Feldstein AE. PMID: 21969091; PMCID: PMC3245344.
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    148. Response to hepatitis A vaccine in children with inflammatory bowel disease receiving infliximab. Inflamm Bowel Dis. 2011 Dec; 17(12):E160. Moses J, Alkhouri N, Shannon A, Feldstein A, Carter-Kent C. PMID: 21953938.
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    149. Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease. Liver Int. 2012 Feb; 32(2):297-302. Alkhouri N, Morris-Stiff G, Campbell C, Lopez R, Tamimi TA, Yerian L, Zein NN, Feldstein AE. PMID: 22097893.
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    150. Hepatitis B immunity and response to booster vaccination in children with inflammatory bowel disease treated with infliximab. Am J Gastroenterol. 2012 Jan; 107(1):133-8. Moses J, Alkhouri N, Shannon A, Raig K, Lopez R, Danziger-Isakov L, Feldstein AE, Zein NN, Wyllie R, Carter-Kent C. PMID: 21876562.
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    151. Pentoxifylline improves nonalcoholic steatohepatitis: a randomized placebo-controlled trial. Hepatology. 2011 Nov; 54(5):1610-9. Zein CO, Yerian LM, Gogate P, Lopez R, Kirwan JP, Feldstein AE, McCullough AJ. PMID: 21748765; PMCID: PMC3205292.
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    152. Identification of a cytochrome P4502E1/Bid/C1q-dependent axis mediating inflammation in adipose tissue after chronic ethanol feeding to mice. J Biol Chem. 2011 Oct 14; 286(41):35989-35997. Sebastian BM, Roychowdhury S, Tang H, Hillian AD, Feldstein AE, Stahl GL, Takahashi K, Nagy LE. PMID: 21856753; PMCID: PMC3195631.
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    153. The use of ultrasound in clinical setting for children affected by NAFLD: is it safe and accurate? Ital J Pediatr. 2011 Aug 02; 37:36. Nobili V, Della Corte C, Monti L, Alisi A, Feldstein A. PMID: 21810223; PMCID: PMC3161934.
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    154. Ultrasonographic quantitative estimation of hepatic steatosis in children With NAFLD. J Pediatr Gastroenterol Nutr. 2011 Aug; 53(2):190-5. Shannon A, Alkhouri N, Carter-Kent C, Monti L, Devito R, Lopez R, Feldstein AE, Nobili V. PMID: 21788761; PMCID: PMC3144505.
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    155. The role of lifestyle changes in the management of chronic liver disease. BMC Med. 2011 Jun 06; 9:70. Nobili V, Carter-Kent C, Feldstein AE. PMID: 21645344; PMCID: PMC3127780.
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    156. Atherogenic dyslipidemia and cardiovascular risk in children with nonalcoholic fatty liver disease. Clin Lipidol. 2011 Jun 01; 6(3):305-314. Alkhouri N, Carter-Kent C, Elias M, Feldstein AE. PMID: 22162978; PMCID: PMC3234131.
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    157. Emerging role of redox dysregulation in alcoholic and nonalcoholic fatty liver disease. Antioxid Redox Signal. 2011 Jul 15; 15(2):421-4. Feldstein AE, Bailey SM. PMID: 21254858; PMCID: PMC3118602.
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    158. NASH animal models: are we there yet? J Hepatol. 2011 Oct; 55(4):941-3. Kohli R, Feldstein AE. PMID: 21708199.
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    159. Transcriptional profile of genes involved in oxidative stress and antioxidant defense in a dietary murine model of steatohepatitis. Antioxid Redox Signal. 2011 Jul 15; 15(2):437-45. Gornicka A, Morris-Stiff G, Thapaliya S, Papouchado BG, Berk M, Feldstein AE. PMID: 21194384; PMCID: PMC3118609.
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    160. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 2011 Apr 07; 472(7341):57-63. Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WH, DiDonato JA, Lusis AJ, Hazen SL. PMID: 21475195; PMCID: PMC3086762.
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    161. Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications. Expert Rev Gastroenterol Hepatol. 2011 Apr; 5(2):201-12. Alkhouri N, Carter-Kent C, Feldstein AE. PMID: 21476915; PMCID: PMC3119461.
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    162. An apoptosis panel for nonalcoholic steatohepatitis diagnosis. J Hepatol. 2011 Jun; 54(6):1224-9. Tamimi TI, Elgouhari HM, Alkhouri N, Yerian LM, Berk MP, Lopez R, Schauer PR, Zein NN, Feldstein AE. PMID: 21145805; PMCID: PMC3098936.
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    163. Non-invasive diagnosis of nonalcoholic fatty liver and nonalcoholic steatohepatitis. J Dig Dis. 2011 Feb; 12(1):10-6. Adams LA, Feldstein AE. PMID: 21091933.
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    164. Relations of steatosis type, grade, and zonality to histological features in pediatric nonalcoholic fatty liver disease. J Pediatr Gastroenterol Nutr. 2011 Feb; 52(2):190-7. Carter-Kent C, Brunt EM, Yerian LM, Alkhouri N, Angulo P, Kohli R, Ling SC, Xanthakos SA, Whitington PF, Charatcharoenwitthaya P, Yap J, Lopez R, McCullough AJ, Feldstein AE. PMID: 21240012.
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    165. Recurrence of Disease Following Liver Transplantation: Nonalcoholic Steatohepatitis vs Hepatitis C Virus Infection. Int J Organ Transplant Med. 2011; 2(2):57-65. Hanouneh IA, Macaron C, Lopez R, Feldstein AE, Yerian L, Eghtesad B, Zein NN. PMID: 25013596; PMCID: PMC4089256.
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    166. Novel insights into the pathophysiology of nonalcoholic fatty liver disease. Semin Liver Dis. 2010 Nov; 30(4):391-401. Feldstein AE. PMID: 20960378.
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    167. Biomarkers in nonalcoholic fatty liver disease: a new era in diagnosis and staging of disease in children. J Pediatr Gastroenterol Nutr. 2010 Oct; 51(4):378-9. Feldstein AE, Nobili V. PMID: 20808243; PMCID: PMC2950320.
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    168. A combination of the pediatric NAFLD fibrosis index and enhanced liver fibrosis test identifies children with fibrosis. Clin Gastroenterol Hepatol. 2011 Feb; 9(2):150-5. Alkhouri N, Carter-Kent C, Lopez R, Rosenberg WM, Pinzani M, Bedogni G, Feldstein AE, Nobili V. PMID: 20888433.
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    169. Nonalcoholic steatohepatitis: risk factors and diagnosis. Expert Rev Gastroenterol Hepatol. 2010 Oct; 4(5):623-35. Adams LA, Feldstein AE. PMID: 20932147.
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    170. High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology. 2010 Sep; 52(3):934-44. Kohli R, Kirby M, Xanthakos SA, Softic S, Feldstein AE, Saxena V, Tang PH, Miles L, Miles MV, Balistreri WF, Woods SC, Seeley RJ. PMID: 20607689; PMCID: PMC2932817.
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    171. Fibroblast growth factor 21 as a biomarker for NAFLD: integrating pathobiology into clinical practice. J Hepatol. 2010 Nov; 53(5):795-6. Morris-Stiff G, Feldstein AE. PMID: 20800308.
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    172. Mass spectrometric profiling of oxidized lipid products in human nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. J Lipid Res. 2010 Oct; 51(10):3046-54. Feldstein AE, Lopez R, Tamimi TA, Yerian L, Chung YM, Berk M, Zhang R, McIntyre TM, Hazen SL. PMID: 20631297; PMCID: PMC2936759.
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    173. Severity of liver injury and atherogenic lipid profile in children with nonalcoholic fatty liver disease. Pediatr Res. 2010 Jun; 67(6):665-70. Nobili V, Alkhouri N, Bartuli A, Manco M, Lopez R, Alisi A, Feldstein AE. PMID: 20496475.
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    174. Chronic alcohol exposure increases circulating bioactive oxidized phospholipids. J Biol Chem. 2010 Jul 16; 285(29):22211-20. Yang L, Latchoumycandane C, McMullen MR, Pratt BT, Zhang R, Papouchado BG, Nagy LE, Feldstein AE, McIntyre TM. PMID: 20460374; PMCID: PMC2903350.
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    175. Autoimmune hepatitis in children--impact of cirrhosis at presentation on natural history and long-term outcome. Dig Liver Dis. 2010 Oct; 42(10):724-8. Radhakrishnan KR, Alkhouri N, Worley S, Arrigain S, Hupertz V, Kay M, Yerian L, Wyllie R, Feldstein AE. PMID: 20163994.
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    176. The inflamed liver and atherosclerosis: a link between histologic severity of nonalcoholic fatty liver disease and increased cardiovascular risk. Dig Dis Sci. 2010 Sep; 55(9):2644-50. Alkhouri N, Tamimi TA, Yerian L, Lopez R, Zein NN, Feldstein AE. PMID: 19960252.
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    177. Diabetes mellitus is associated with impaired response to antiviral therapy in chronic hepatitis C infection. Dig Dis Sci. 2009 Dec; 54(12):2699-705. Elgouhari HM, Zein CO, Hanouneh I, Feldstein AE, Zein NN. PMID: 19148751.
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    178. Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis. J Biol Chem. 2010 Jan 29; 285(5):3428-38. Alkhouri N, Gornicka A, Berk MP, Thapaliya S, Dixon LJ, Kashyap S, Schauer PR, Feldstein AE. PMID: 19940134; PMCID: PMC2823448.
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    179. Serum retinol-binding protein 4 levels in patients with nonalcoholic fatty liver disease. J Clin Gastroenterol. 2009 Nov-Dec; 43(10):985-9. Alkhouri N, Lopez R, Berk M, Feldstein AE. PMID: 19525859; PMCID: PMC2783954.
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    180. Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study. Hepatology. 2009 Oct; 50(4):1113-20. Carter-Kent C, Yerian LM, Brunt EM, Angulo P, Kohli R, Ling SC, Xanthakos SA, Whitington PF, Charatcharoenwitthaya P, Yap J, Lopez R, McCullough AJ, Feldstein AE. PMID: 19637190; PMCID: PMC2775705.
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    181. Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study. Hepatology. 2009 Oct; 50(4):1072-8. Feldstein AE, Wieckowska A, Lopez AR, Liu YC, Zein NN, McCullough AJ. PMID: 19585618; PMCID: PMC2757511.
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    182. Suppression of mitochondrial function by oxidatively truncated phospholipids is reversible, aided by bid, and suppressed by Bcl-XL. J Biol Chem. 2009 Sep 25; 284(39):26297-308. Chen R, Feldstein AE, McIntyre TM. PMID: 19654426; PMCID: PMC2785317.
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    183. Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal. Expert Rev Gastroenterol Hepatol. 2009 Aug; 3(4):445-51. Alkhouri N, Dixon LJ, Feldstein AE. PMID: 19673631; PMCID: PMC2775708.
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    184. Non-alcoholic steatohepatitis over multiple generations. Dig Dis Sci. 2010 May; 55(5):1494-7. Carter-Kent C, Feldstein AE. PMID: 19629685.
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    185. The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years. Gut. 2009 Nov; 58(11):1538-44. Feldstein AE, Charatcharoenwitthaya P, Treeprasertsuk S, Benson JT, Enders FB, Angulo P. PMID: 19625277; PMCID: PMC2792743.
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    186. Triglyceride levels and not adipokine concentrations are closely related to severity of nonalcoholic fatty liver disease in an obesity surgery cohort. Obesity (Silver Spring). 2009 Sep; 17(9):1696-701. Kashyap SR, Diab DL, Baker AR, Yerian L, Bajaj H, Gray-McGuire C, Schauer PR, Gupta M, Feldstein AE, Hazen SL, Stein CM. PMID: 19360015; PMCID: PMC2829436.
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    187. Severe hepatocellular injury with apoptosis induced by a hepatitis C polymerase inhibitor. J Clin Gastroenterol. 2009 Apr; 43(4):374-81. Feldstein A, Kleiner D, Kravetz D, Buck M. PMID: 19098685; PMCID: PMC8391074.
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    188. Role of interleukin-6 in human nonalcoholic steatohepatitis. Response to Dogru et al. Am J Gastroenterol. 2009 Mar; 104(3):author reply 788. Wieckowska A, Papouchado BG, Li Z, Lopez R, Zein NN, Feldstein AE. PMID: 19174778.
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    189. Retinol-binding protein 4: a promising circulating marker of liver damage in pediatric nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2009 May; 7(5):575-9. Nobili V, Alkhouri N, Alisi A, Ottino S, Lopez R, Manco M, Feldstein AE. PMID: 19268270.
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    190. Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase. J Biol Chem. 2009 Feb 27; 284(9):5637-44. Li ZZ, Berk M, McIntyre TM, Feldstein AE. PMID: 19119140; PMCID: PMC2645822.
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    191. Diagnosis of nonalcoholic fatty liver disease: invasive versus noninvasive. Semin Liver Dis. 2008 Nov; 28(4):386-95. Wieckowska A, Feldstein AE. PMID: 18956295.
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    192. The significance of metabolic syndrome in the setting of recurrent hepatitis C after liver transplantation. Liver Transpl. 2008 Sep; 14(9):1287-93. Hanouneh IA, Feldstein AE, McCullough AJ, Miller C, Aucejo F, Yerian L, Lopez R, Zein NN. PMID: 18756451.
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    193. Cytokeratin 18 fragment levels as a noninvasive biomarker for nonalcoholic steatohepatitis in bariatric surgery patients. Clin Gastroenterol Hepatol. 2008 Nov; 6(11):1249-54. Diab DL, Yerian L, Schauer P, Kashyap SR, Lopez R, Hazen SL, Feldstein AE. PMID: 18995215; PMCID: PMC2628560.
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    194. Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis. Am J Gastroenterol. 2008 Jun; 103(6):1372-9. Wieckowska A, Papouchado BG, Li Z, Lopez R, Zein NN, Feldstein AE. PMID: 18510618.
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    195. Clinical significance of metabolic syndrome in the setting of chronic hepatitis C virus infection. Clin Gastroenterol Hepatol. 2008 May; 6(5):584-9. Hanouneh IA, Feldstein AE, Lopez R, Yerian L, Pillai A, Zein CO, Zein NN. PMID: 18455698.
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    196. The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity. Hepatology. 2008 May; 47(5):1495-503. Li Z, Berk M, McIntyre TM, Gores GJ, Feldstein AE. PMID: 18220271; PMCID: PMC3025414.
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    197. Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: implications for treatment. Am J Gastroenterol. 2008 Apr; 103(4):1036-42. Carter-Kent C, Zein NN, Feldstein AE. PMID: 18177455.
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    198. Increasing calories, decreasing morbidity and mortality: is improved nutrition the answer to better outcomes in patients with biliary atresia? Hepatology. 2007 Nov; 46(5):1329-31. Carter-Kent C, Radhakrishnan K, Feldstein AE. PMID: 17969044.
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    199. Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future. Hepatology. 2007 Aug; 46(2):582-9. Wieckowska A, McCullough AJ, Feldstein AE. PMID: 17661414.
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    200. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology. 2006 Jul; 44(1):27-33. Wieckowska A, Zein NN, Yerian LM, Lopez AR, McCullough AJ, Feldstein AE. PMID: 16799979.
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    201. Bax inhibition protects against free fatty acid-induced lysosomal permeabilization. Am J Physiol Gastrointest Liver Physiol. 2006 Jun; 290(6):G1339-46. Feldstein AE, Werneburg NW, Li Z, Bronk SF, Gores GJ. PMID: 16484678; PMCID: PMC3056273.
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    202. Nonalcoholic fatty liver disease in the pediatric population: a review. Curr Opin Pediatr. 2005 Oct; 17(5):636-41. Wieckowska A, Feldstein AE. PMID: 16160540.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    203. Apoptosis in alcoholic and nonalcoholic steatohepatitis. Front Biosci. 2005 Sep 01; 10:3093-9. Feldstein AE, Gores GJ. PMID: 15970563.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    204. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology. 2005 Jul; 129(1):113-21. Adams LA, Lymp JF, St Sauver J, Sanderson SO, Lindor KD, Feldstein A, Angulo P. PMID: 16012941.
      View in: PubMed   Mentions: 1063     Fields:    Translation:Humans
    205. Hepatic stellate cells and fibrosis progression in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2005 Apr; 3(4):384-9. Feldstein AE, Papouchado BG, Angulo P, Sanderson S, Adams L, Gores GJ. PMID: 15822044.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    206. Effect of lifestyle modifications on blood pressure by race, sex, hypertension status, and age. J Hum Hypertens. 2005 Jan; 19(1):21-31. Svetkey LP, Erlinger TP, Vollmer WM, Feldstein A, Cooper LS, Appel LJ, Ard JD, Elmer PJ, Harsha D, Stevens VJ. PMID: 15385946.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCTClinical Trials
    207. An apoptosis biomarker goes to the HCV clinic. Hepatology. 2004 Nov; 40(5):1044-6. Feldstein AE, Gores GJ. PMID: 15486920.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    208. Steatohepatitis and apoptosis: therapeutic implications. Am J Gastroenterol. 2004 Sep; 99(9):1718-9. Feldstein A, Gores GJ. PMID: 15330908.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    209. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology. 2004 Jul; 40(1):185-94. Feldstein AE, Werneburg NW, Canbay A, Guicciardi ME, Bronk SF, Rydzewski R, Burgart LJ, Gores GJ. PMID: 15239102.
      View in: PubMed   Mentions: 300     Fields:    Translation:HumansAnimalsCells
    210. Nonalcoholic fatty liver disease among patients with hypothalamic and pituitary dysfunction. Hepatology. 2004 Apr; 39(4):909-14. Adams LA, Feldstein A, Lindor KD, Angulo P. PMID: 15057893.
      View in: PubMed   Mentions: 73     Fields:    Translation:Humans
    211. Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice. J Hepatol. 2003 Dec; 39(6):978-83. Feldstein AE, Canbay A, Guicciardi ME, Higuchi H, Bronk SF, Gores GJ. PMID: 14642615.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
    212. The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse. J Pharmacol Exp Ther. 2004 Mar; 308(3):1191-6. Canbay A, Feldstein A, Baskin-Bey E, Bronk SF, Gores GJ. PMID: 14617689.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    213. Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression. Hepatology. 2003 Nov; 38(5):1188-98. Canbay A, Feldstein AE, Higuchi H, Werneburg N, Grambihler A, Bronk SF, Gores GJ. PMID: 14578857.
      View in: PubMed   Mentions: 190     Fields:    Translation:AnimalsCells
    214. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology. 2003 Aug; 125(2):437-43. Feldstein AE, Canbay A, Angulo P, Taniai M, Burgart LJ, Lindor KD, Gores GJ. PMID: 12891546.
      View in: PubMed   Mentions: 405     Fields:    Translation:HumansCells
    215. Primary sclerosing cholangitis in children: a long-term follow-up study. Hepatology. 2003 Jul; 38(1):210-7. Feldstein AE, Perrault J, El-Youssif M, Lindor KD, Freese DK, Angulo P. PMID: 12830004.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    216. Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis. J Clin Invest. 2003 Jul; 112(2):152-9. Canbay A, Guicciardi ME, Higuchi H, Feldstein A, Bronk SF, Rydzewski R, Taniai M, Gores GJ. PMID: 12865404; PMCID: PMC164289.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    217. Lipid-lowering-independent effects of simvastatin on the kidney in experimental hypercholesterolaemia. Nephrol Dial Transplant. 2003 Apr; 18(4):703-9. Wilson SH, Chade AR, Feldstein A, Sawamura T, Napoli C, Lerman A, Lerman LO. PMID: 12637638.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    218. Chronic intestinal pseudoobstruction associated with altered interstitial cells of cajal networks. J Pediatr Gastroenterol Nutr. 2003 Apr; 36(4):492-7. Feldstein AE, Miller SM, El-Youssef M, Rodeberg D, Lindor NM, Burgart LJ, Szurszewski JH, Farrugia G. PMID: 12658043.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    219. Prevalence and clinical significance of human herpesviruses 6 and 7 active infection in pediatric liver transplant patients. Pediatr Transplant. 2003 Apr; 7(2):125-9. Feldstein AE, Razonable RR, Boyce TG, Freese DK, El-Youssef M, Perrault J, Paya CV, Ishitani MB. PMID: 12654053.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    220. In vivo renal vascular and tubular function in experimental hypercholesterolemia. Hypertension. 1999 Oct; 34(4 Pt 2):859-64. Feldstein A, Krier JD, Sarafov MH, Lerman A, Best PJ, Wilson SH, Lerman LO. PMID: 10523374.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    221. New insights into the pathophysiology of renovascular hypertension. Mayo Clin Proc. 1997 Mar; 72(3):251-60. Romero JC, Feldstein AE, Rodriguez-Porcel MG, Cases-Amenos A. PMID: 9070202.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    222. The effect of ethanol on the in vivo conversion of 5-HTP-14C to serotonin-14C, 5-hydroxyindoleacetaldehyde-14C and its metabolites in rat brain. Int J Neuropharmacol. 1969 Jul; 8(4):347-51. Feldstein A, Sidel CM. PMID: 5307042.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
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