Sara Browne

Title(s)Recall Faculty, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Sara H. Browne, M.D. is a Professor of Clinical Medicine in the Department of Medicine, Division of Infectious Diseases, at the University of California, San Diego (UCSD). Dr. Browne received her undergraduate education at the University of Cape Town, RSA and her medical degree from the Oxford University School of Medicine. She has a master of public health from the Harvard University School of Public Health, where she was a Fulbright Scholar. She completed her license in the United Kingdom at the John Radcliffe Hospital, Oxford, UK. She did her residency in Internal Medicine at Stanford University Medical Center, where subsequently completed a Clinical Pharmacology Fellowship at Stanford University and an Infectious Diseases Fellowship at UCSD.

    Since joining the UCSD faculty in 2006, Dr. Browne’s main focus has been Global Health and more recently Mobile Health. She has partnered with 3 institutions in South Africa (Stellenbosch University in the Western Cape and Rhodes University, Walter Sisulu University in the Eastern Cape) to support the development of skilled medically trained research faculty locally to better address clinical research questions crucial to the combat and treatment of the HIV/TB epidemics in Southern Africa. She has successfully mentored South African medical faculty in the design and development of three NIH-funded international HIV research projects in the areas of ART adherence, metabolic side effects in ART and transmitted HIV resistance. Research from these partnerships continue to yield both vital clinical data and clinical tools to implement in the field.

    Dr. Browne currently conducts translational research and clinical trials to analyze and support patient medication adherence and promote medication literacy in the treatment of HIV/AIDS, TB, and chronic diseases. She seeks to provide new paradigms of healthcare delivery especially in the arena of patient self-management with the use of novel mobile health (mHealth) technologies. Her collaborators include. In collaboration with Proteus Digital Health., who have developed an ingestible event marker that is able to capture oral ingestion medication, Dr. Browne is investigating the efficacy of mHealth sensor technology to monitor treatment of Mycobacterium tuberculosis. She is an Alliance Healthcare Foundation Innovation Award recipient for this work.

    Dr. Browne is the Principal Investigator in NIH R01 funded research into the use of ingestion sensor technology in the treatment and prevention of HIV infection. She is also funded to preform clinical trials on cell phone based remote vital sign monitoring.

    Collapse Research 
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    The Vital Case System for Remote Monitoring Multiple Vital Signs Simultaneously on Cell Phones
    NIH/NIMH R01MH110057 S3&4Jan 10, 2018 - Jul 31, 2022
    Role: Principal Investigator
    A Novel Wireless Ingestible Sensor System for Measurement of Medication Adherence in HIV Treatment and Prevention
    NIH R01MH110057Sep 20, 2015 - Jul 31, 2021
    Role: Principal Investigator
    Screening for Atherosclerotic Vascular Disease in HIV-Infected Children
    NIH R01 HD083042-01May 5, 2015 - Apr 2, 2020
    Role: Principal Investigator
    Salmonella-induced Cytopathology in Human Macrophages
    NIH K08AI062758May 15, 2005 - Apr 30, 2011
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Genomic surveillance reveals dynamic shifts in the connectivity of COVID-19 epidemics. Cell. 2023 12 21; 186(26):5690-5704.e20. Matteson NL, Hassler GW, Kurzban E, Schwab MA, Perkins SA, Gangavarapu K, Levy JI, Parker E, Pride D, Hakim A, De Hoff P, Cheung W, Castro-Martinez A, Rivera A, Veder A, Rivera A, Wauer C, Holmes J, Wilson J, Ngo SN, Plascencia A, Lawrence ES, Smoot EW, Eisner ER, Tsai R, Chacón M, Baer NA, Seaver P, Salido RA, Aigner S, Ngo TT, Barber T, Ostrander T, Fielding-Miller R, Simmons EH, Zazueta OE, Serafin-Higuera I, Sanchez-Alavez M, Moreno-Camacho JL, García-Gil A, Murphy Schafer AR, McDonald E, Corrigan J, Malone JD, Stous S, Shah S, Moshiri N, Weiss A, Anderson C, Aceves CM, Spencer EG, Hufbauer EC, Lee JJ, King AJ, Ramesh KS, Nguyen KN, Saucedo K, Robles-Sikisaka R, Fisch KM, Gonias SL, Birmingham A, McDonald D, Karthikeyan S, Martin NK, Schooley RT, Negrete AJ, Reyna HJ, Chavez JR, Garcia ML, Cornejo-Bravo JM, Becker D, Isaksson M, Washington NL, Lee W, Garfein RS, Luna-Ruiz Esparza MA, Alcántar-Fernández J, Henson B, Jepsen K, Olivares-Flores B, Barrera-Badillo G, Lopez-Martínez I, Ramírez-González JE, Flores-León R, Kingsmore SF, Sanders A, Pradenas A, White B, Matthews G, Hale M, McLawhon RW, Reed SL, Winbush T, McHardy IH, Fielding RA, Nicholson L, Quigley MM, Harding A, Mendoza A, Bakhtar O, Browne SH, Olivas Flores J, Rincon Rodríguez DG, Gonzalez Ibarra M, Robles Ibarra LC, Arellano Vera BJ, Gonzalez Garcia J, Harvey-Vera A, Knight R, Laurent LC, Yeo GW, Wertheim JO, Ji X, Worobey M, Suchard MA, Andersen KG, Campos-Romero A, Wohl S, Zeller M. PMID: 38101407; PMCID: PMC10795731.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    2. Lung function tracking in children with perinatally acquired HIV following early antiretroviral therapy initiation. Thorax. 2023 12; 78(12):1233-1239. Gie A, Davies C, Vaida F, Morrison J, Maree D, Otwombe K, Browne SH, van der Zalm MM, Cotton MF, Innes S, Goussard P. PMID: 37479478; PMCID: PMC10715541.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Decreased Hepatic Steatosis in South African Adolescents With Perinatal HIV Switching to Dolutegravir-containing Regimens. Pediatr Infect Dis J. 2023 Jul 01; 42(7):564-572. Rose PC, De la Rey Nel E, Cotton MF, Otwombe K, Browne SH, Frigati LJ, Rabie H, Innes S. PMID: 36917035; PMCID: PMC10257761.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Pulse wave velocity in early-treated children living with perinatal HIV infection is similar to uninfected children. AIDS. 2023 06 01; 37(7):1115-1123. Davies C, Vaida F, Otwombe K, Cotton MF, Browne SH, Innes S. PMID: 36928069; PMCID: PMC10164068.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Supporting the Art: Medication Adherence Patterns in Persons Prescribed Ingestible Sensor-enabled Oral Pre-Exposure Prophylaxis to Prevent Human Immunodeficiency Virus Infection. Clin Infect Dis. 2023 01 06; 76(1):134-143. Browne SH, Vaida F, Umlauf A, Tucker AJ, Blaschke TF, Benson CA. PMID: 36484300; PMCID: PMC10202440.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    6. Prevalence and Risk Factors for Hepatic Steatosis in Children With Perinatal HIV on Early Antiretroviral Therapy Compared to HIV-Exposed Uninfected and HIV-Unexposed Children. Front Pediatr. 2022; 10:893579. Rose PC, Nel ED, Cotton MF, Pitcher RD, Otwombe K, Browne SH, Innes S. PMID: 35757117; PMCID: PMC9218275.
      View in: PubMed   Mentions:
    7. Childhood lung function following perinatal HIV infection and early antiretroviral therapy initiation: a cross-sectional study. ERJ Open Res. 2022 Jan; 8(1). Gie A, Morrison J, Maree D, Laughton B, Browne SH, Cotton MF, Goussard P, Innes S. PMID: 35350281; PMCID: PMC8943286.
      View in: PubMed   Mentions: 1  
    8. Earlier antiretroviral initiation is independently associated with better arterial stiffness in children living with perinatally acquired HIV with sustained viral suppression in Mozambique. South Afr J HIV Med. 2021; 22(1):1282. Dobe IS, Mocumbi AO, Majid N, Ayele B, Browne SH, Innes S. PMID: 34858652; PMCID: PMC8603154.
      View in: PubMed   Mentions: 2  
    9. Accuracy of Samsung Smartphone Integrated Pulse Oximetry Meets Full FDA Clearance Standards for Clinical Use. medRxiv. 2021 Feb 18. Browne SH, Bernstein M, Bickler PE. PMID: 33619504; PMCID: PMC7899474.
      View in: PubMed   Mentions: 2  
    10. Smartphone Biosensor With App Meets FDA/ISO Standards for Clinical Pulse Oximetry and Can Be Reliably Used by a Wide Range of Patients. Chest. 2021 02; 159(2):724-732. Browne SH, Bernstein M, Pan SC, Gonzalez Garcia J, Easson CA, Huang CC, Vaida F. PMID: 32926871; PMCID: PMC7485544.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansPHPublic Health
    11. Wirelessly observed therapy compared to directly observed therapy to confirm and support tuberculosis treatment adherence: A randomized controlled trial. PLoS Med. 2019 10; 16(10):e1002891. Browne SH, Umlauf A, Tucker AJ, Low J, Moser K, Gonzalez Garcia J, Peloquin CA, Blaschke T, Vaida F, Benson CA. PMID: 31584944; PMCID: PMC6777756.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    12. The impact of illustrated side effect information on understanding and sustained retention of antiretroviral side effect knowledge. Res Social Adm Pharm. 2019 04; 15(4):469-473. Browne SH, Barford K, Ramela T, Dowse R. PMID: 29803539.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    13. Digitizing Medicines for Remote Capture of Oral Medication Adherence Using Co-encapsulation. Clin Pharmacol Ther. 2018 03; 103(3):502-510. Browne SH, Peloquin C, Santillo F, Haubrich R, Muttera L, Moser K, Savage GM, Benson CA, Blaschke TF. PMID: 28597911; PMCID: PMC5836848.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    14. mTOR activity in AIDS-related diffuse large B-cell lymphoma. PLoS One. 2017; 12(2):e0170771. Browne SH, Diaz-Perez JA, Preziosi M, King CC, Jones GA, Jain S, Sun X, Reid EG, VandenBerg S, Wang HY. PMID: 28192480; PMCID: PMC5305194.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    15. High Prevalence of Dyslipidemia and Insulin Resistance in HIV-infected Prepubertal African Children on Antiretroviral Therapy. Pediatr Infect Dis J. 2016 Jan; 35(1):e1-7. Innes S, Abdullah KL, Haubrich R, Cotton MF, Browne SH. PMID: 26421804; PMCID: PMC4707556.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    16. Let Visuals Tell the Story: Medication Adherence in Patients with Type II Diabetes Captured by a Novel Ingestion Sensor Platform. JMIR Mhealth Uhealth. 2015 Dec 31; 3(4):e108. Browne SH, Behzadi Y, Littlewort G. PMID: 26721413; PMCID: PMC4713908.
      View in: PubMed   Mentions: 19     Fields:    
    17. Simple, illustrated medicines information improves ARV knowledge and patient self-efficacy in limited literacy South African HIV patients. AIDS Care. 2014; 26(11):1400-6. Dowse R, Barford K, Browne SH. PMID: 24975116; PMCID: PMC4124945.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    18. Biceps skin-fold thickness may detect and predict early lipoatrophy in HIV-infected children. Pediatr Infect Dis J. 2013 Jun; 32(6):e254-62. Innes S, Schulte-Kemna E, Cotton MF, Zöllner EW, Haubrich R, Klinker H, Sun X, Jain S, Edson C, van Niekerk M, Innes ER, Rabie H, Browne SH. PMID: 23249919; PMCID: PMC4000309.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. Editorial commentary: dialing for doses: enhancing community-based adherence support with mobile technologies. Clin Infect Dis. 2013 May; 56(9):1327-9. Browne SH. PMID: 23249610.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. High prevalence of lipoatrophy in pre-pubertal South African children on antiretroviral therapy: a cross-sectional study. BMC Pediatr. 2012 Nov 23; 12:183. Innes S, Cotton MF, Haubrich R, Conradie MM, van Niekerk M, Edson C, Rabie H, Jain S, Sun X, Zöllner EW, Hough S, Browne SH. PMID: 23176441; PMCID: PMC3584923.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    21. Microbiological analysis of nontyphoidal Salmonella strains causing distinct syndromes of bacteremia or enteritis in HIV/AIDS patients in San Diego, California. J Clin Microbiol. 2012 Nov; 50(11):3598-603. Preziosi MJ, Kandel SM, Guiney DG, Browne SH. PMID: 22933605; PMCID: PMC3486235.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    22. An illustrated leaflet containing antiretroviral information targeted for low-literate readers: development and evaluation. Patient Educ Couns. 2011 Dec; 85(3):508-15. Dowse R, Ramela T, Browne SH. PMID: 21306856.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    23. Penetration and activation of brain endothelium by Salmonella enterica serovar Typhimurium. J Infect Dis. 2011 Feb 01; 203(3):401-5. van Sorge NM, Zialcita PA, Browne SH, Quach D, Guiney DG, Doran KS. PMID: 21186258; PMCID: PMC3071103.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    24. Identification of Salmonella SPI-2 secretion system components required for SpvB-mediated cytotoxicity in macrophages and virulence in mice. FEMS Immunol Med Microbiol. 2008 Mar; 52(2):194-201. Browne SH, Hasegawa P, Okamoto S, Fierer J, Guiney DG. PMID: 18248436.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    25. [On the effect of anticoagulants]. Wien Med Wochenschr. 1965 Jul 17; 115(29):606-8. Vinazzer H. PMID: 5836848.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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