Hannah Carter
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Title(s) | Associate Professor, Medicine |
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School | Vc-health Sciences-schools |
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Address | 9500 Gilman Drive # La Jolla CA 92093
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vCard | Download vCard |
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Biography University of Louisville, Kentucky | MEng | 12/2004 | Electrical and Computer Engineering | Johns Hopkins University, Maryland | PhD | 02/2012 | Biomedical Engineering |
Canadian Institute for Advanced Research (CIFAR) | 2017 | | Azrieli Global Scholar | Johns Hopkins University | 2015 | | Johns Hopkins University Alumni Outstanding Recent Graduate Award | NIH | 2013 | | NIH Director's Early Independence Award | Siebel Scholars Foundation | 2012 | | Siebel Scholar |
Overview Dr. Hannah Carter’s research focuses on computationally modeling how DNA mutations in tumor genomes impact intracellular biological processes and cellular behaviors, and how these cellular level changes cause cancer. In 2013, Dr. Carter received a prestigious NIH Early Independence Award for her project, Network Approaches to Identify Cancer Drivers from High-Dimensional Tumor Data - Read UC San Diego Clinical and Translational Research Institute News Story Research ORNG Applications Bibliographic
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Mutation hotspots may not be drug targets. Science. 2019 06 28; 364(6447):1228-1229.
Carter H. PMID: 31249043.
View in: PubMed Mentions: Fields: Translation: Humans
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MHC-I Genotype Restricts the Oncogenic Mutational Landscape. Cell. 2017.
Rachel Marty
Saghar Kaabinejadian
David Rossell
Michael J. Slifker
Joris van de Haar
Hatice Billur Engin
Nicola de Prisco
Trey Ideker
William H. Hildebrand
Joan Font-Burgada
Hannah Carter. .
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Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment. Genome Biol. 2017 03 28; 18(1):57.
Wang T, Tsui B, Kreisberg JF, Robertson NA, Gross AM, Yu MK, Carter H, Brown-Borg HM, Adams PD, Ideker T. PMID: 28351423.
View in: PubMed Mentions: 37 Fields: Translation: HumansAnimalsCells
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Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer. Cancer Discov. 2017 04; 7(4):410-423.
Carter H, Marty R, Hofree M, Gross AM, Jensen J, Fisch KM, Wu X, DeBoever C, Van Nostrand EL, Song Y, Wheeler E, Kreisberg JF, Lippman SM, Yeo GW, Gutkind JS, Ideker T. PMID: 28188128.
View in: PubMed Mentions: 34 Fields: Translation: HumansCells
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Immune DNA signature of T-cell infiltration in breast tumor exomes. Sci Rep. 2016 07 25; 6:30064.
Levy E, Marty R, Gárate Calderón V, Woo B, Dow M, Armisen R, Carter H, Harismendy O. PMID: 27452728.
View in: PubMed Mentions: 7 Fields: Translation: HumansCells
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Challenges in identifying cancer genes by analysis of exome sequencing data. Nat Commun. 2016 07 15; 7:12096.
Hofree M, Carter H, Kreisberg JF, Bandyopadhyay S, Mischel PS, Friend S, Ideker T. PMID: 27417679.
View in: PubMed Mentions: 13 Fields: Translation: Humans
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VarI-SIG 2015: methods for personalized medicine - the role of variant interpretation in research and diagnostics. BMC Genomics. 2016 06 23; 17 Suppl 2:425.
Bromberg Y, Capriotti E, Carter H. PMID: 27357578.
View in: PubMed Mentions: 1 Fields: Translation: HumansCells
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Structure-Based Analysis Reveals Cancer Missense Mutations Target Protein Interaction Interfaces. PLoS One. 2016; 11(4):e0152929.
Engin HB, Kreisberg JF, Carter H. PMID: 27043210.
View in: PubMed Mentions: 18 Fields: Translation: HumansCells
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Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer. Cell. 2015 Aug 13; 162(4):766-79.
Font-Burgada J, Shalapour S, Ramaswamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek MA, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M. PMID: 26276631.
View in: PubMed Mentions: 111 Fields: Translation: AnimalsCells
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Identifying mutation specific cancer pathways using a structurally resolved protein interaction network. Pac Symp Biocomput. 2015; 84-95.
Engin HB, Hofree M, Carter H. PMID: 25592571.
View in: PubMed Mentions: 3 Fields: Translation: Humans
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A probabilistic model to predict clinical phenotypic traits from genome sequencing. PLoS Comput Biol. 2014 Sep; 10(9):e1003825.
Chen YC, Douville C, Wang C, Niknafs N, Yeo G, Beleva-Guthrie V, Carter H, Stenson PD, Cooper DN, Li B, Mooney S, Karchin R. PMID: 25188385.
View in: PubMed Mentions: 4 Fields: Translation: Humans
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Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss. Nat Genet. 2014 Sep; 46(9):939-43.
Gross AM, Orosco RK, Shen JP, Egloff AM, Carter H, Hofree M, Choueiri M, Coffey CS, Lippman SM, Hayes DN, Cohen EE, Grandis JR, Nguyen QT, Ideker T. PMID: 25086664.
View in: PubMed Mentions: 52 Fields: Translation: HumansCells
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Predicting the functional consequences of somatic missense mutations found in tumors. Methods Mol Biol. 2014; 1101:135-59.
Carter H, Karchin R. PMID: 24233781.
View in: PubMed Mentions: 6 Fields: Translation: Humans
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Genotype to phenotype via network analysis. Curr Opin Genet Dev. 2013 Dec; 23(6):611-21.
Carter H, Hofree M, Ideker T. PMID: 24238873.
View in: PubMed Mentions: 37 Fields: Translation: Humans
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Network-based stratification of tumor mutations. Nat Methods. 2013 Nov; 10(11):1108-15.
Hofree M, Shen JP, Carter H, Gross A, Ideker T. PMID: 24037242.
View in: PubMed Mentions: 251 Fields: Translation: Humans
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Computational approaches to identify functional genetic variants in cancer genomes. Nat Methods. 2013 Aug; 10(8):723-9.
Gonzalez-Perez A, Mustonen V, Reva B, Ritchie GR, Creixell P, Karchin R, Vazquez M, Fink JL, Kassahn KS, Pearson JV, Bader GD, Boutros PC, Muthuswamy L, Ouellette BF, Reimand J, Linding R, Shibata T, Valencia A, Butler A, Dronov S, Flicek P, Shannon NB, Carter H, Ding L, Sander C, Stuart JM, Stein LD, Lopez-Bigas N, . PMID: 23900255.
View in: PubMed Mentions: 71 Fields: Translation: Humans
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Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13481-6.
Gartner JJ, Parker SC, Prickett TD, Dutton-Regester K, Stitzel ML, Lin JC, Davis S, Simhadri VL, Jha S, Katagiri N, Gotea V, Teer JK, Wei X, Morken MA, Bhanot UK, , Chen G, Elnitski LL, Davies MA, Gershenwald JE, Carter H, Karchin R, Robinson W, Robinson S, Rosenberg SA, Collins FS, Parmigiani G, Komar AA, Kimchi-Sarfaty C, Hayward NK, Margulies EH, Samuels Y. PMID: 23901115.
View in: PubMed Mentions: 66 Fields: Translation: HumansCells
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Identifying Mendelian disease genes with the variant effect scoring tool. BMC Genomics. 2013; 14 Suppl 3:S3.
Carter H, Douville C, Stenson PD, Cooper DN, Karchin R. PMID: 23819870.
View in: PubMed Mentions: 93 Fields: Translation: Humans
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A hybrid likelihood model for sequence-based disease association studies. PLoS Genet. 2013; 9(1):e1003224.
Chen YC, Carter H, Parla J, Kramer M, Goes FS, Pirooznia M, Zandi PP, McCombie WR, Potash JB, Karchin R. PMID: 23358228.
View in: PubMed Mentions: 11 Fields: Translation: HumansCells
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CRAVAT: cancer-related analysis of variants toolkit. Bioinformatics. 2013 Mar 01; 29(5):647-8.
Douville C, Carter H, Kim R, Niknafs N, Diekhans M, Stenson PD, Cooper DN, Ryan M, Karchin R. PMID: 23325621.
View in: PubMed Mentions: 49 Fields: Translation: Humans
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Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer. Genome Res. 2012 Nov; 22(11):2120-9.
Liang H, Cheung LW, Li J, Ju Z, Yu S, Stemke-Hale K, Dogruluk T, Lu Y, Liu X, Gu C, Guo W, Scherer SE, Carter H, Westin SN, Dyer MD, Verhaak RG, Zhang F, Karchin R, Liu CG, Lu KH, Broaddus RR, Scott KL, Hennessy BT, Mills GB. PMID: 23028188.
View in: PubMed Mentions: 99 Fields: Translation: HumansCells
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Somatic mutations in the Notch, NF-KB, PIK3CA, and Hedgehog pathways in human breast cancers. Genes Chromosomes Cancer. 2012 May; 51(5):480-9.
Jiao X, Wood LD, Lindman M, Jones S, Buckhaults P, Polyak K, Sukumar S, Carter H, Kim D, Karchin R, Sjöblom T. PMID: 22302350.
View in: PubMed Mentions: 32 Fields: Translation: HumansCells
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Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21188-93.
Wu J, Jiao Y, Dal Molin M, Maitra A, de Wilde RF, Wood LD, Eshleman JR, Goggins MG, Wolfgang CL, Canto MI, Schulick RD, Edil BH, Choti MA, Adsay V, Klimstra DS, Offerhaus GJ, Klein AP, Kopelovich L, Carter H, Karchin R, Allen PJ, Schmidt CM, Naito Y, Diaz LA, Kinzler KW, Papadopoulos N, Hruban RH, Vogelstein B. PMID: 22158988.
View in: PubMed Mentions: 177 Fields: Translation: HumansCells
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Integrated genomic analyses of ovarian carcinoma. Nature. 2011 Jun 29; 474(7353):609-15.
Cancer Genome Atlas Research Network . PMID: 21720365.
View in: PubMed Mentions: 2459 Fields: Translation: HumansCells
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Sequence analysis of 515 kinase genes in chronic lymphocytic leukemia. Leukemia. 2011 Dec; 25(12):1908-10.
Zhang X, Reis M, Khoriaty R, Li Y, Ouillette P, Samayoa J, Carter H, Karchin R, Li M, Diaz LA, Velculescu VE, Papadopoulos N, Kinzler KW, Vogelstein B, Malek SN. PMID: 21701494.
View in: PubMed Mentions: 10 Fields: Translation: Humans
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CHASM and SNVBox: toolkit for detecting biologically important single nucleotide mutations in cancer. Bioinformatics. 2011 Aug 01; 27(15):2147-8.
Wong WC, Kim D, Carter H, Diekhans M, Ryan MC, Karchin R. PMID: 21685053.
View in: PubMed Mentions: 34 Fields: Translation: HumansCells
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The genetic landscape of the childhood cancer medulloblastoma. Science. 2011 Jan 28; 331(6016):435-9.
Parsons DW, Li M, Zhang X, Jones S, Leary RJ, Lin JC, Boca SM, Carter H, Samayoa J, Bettegowda C, Gallia GL, Jallo GI, Binder ZA, Nikolsky Y, Hartigan J, Smith DR, Gerhard DS, Fults DW, VandenBerg S, Berger MS, Marie SK, Shinjo SM, Clara C, Phillips PC, Minturn JE, Biegel JA, Judkins AR, Resnick AC, Storm PB, Curran T, He Y, Rasheed BA, Friedman HS, Keir ST, McLendon R, Northcott PA, Taylor MD, Burger PC, Riggins GJ, Karchin R, Parmigiani G, Bigner DD, Yan H, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE. PMID: 21163964.
View in: PubMed Mentions: 357 Fields: Translation: HumansCells
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Accumulation of driver and passenger mutations during tumor progression. Proc Natl Acad Sci U S A. 2010 Oct 26; 107(43):18545-50.
Bozic I, Antal T, Ohtsuki H, Carter H, Kim D, Chen S, Karchin R, Kinzler KW, Vogelstein B, Nowak MA. PMID: 20876136.
View in: PubMed Mentions: 275 Fields: Translation: Humans
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Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM). . 2010 Sep 15; 10(6):582-7.
Carter H, Samayoa J, Hruban RH, Karchin R. PMID: 20581473.
View in: PubMed Mentions:
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Cancer-specific high-throughput annotation of somatic mutations: computational prediction of driver missense mutations. Cancer Res. 2009 Aug 15; 69(16):6660-7.
Carter H, Chen S, Isik L, Tyekucheva S, Velculescu VE, Kinzler KW, Vogelstein B, Karchin R. PMID: 19654296.
View in: PubMed Mentions: 186 Fields: Translation: Humans
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MODBASE, a database of annotated comparative protein structure models and associated resources. Nucleic Acids Res. 2009 Jan; 37(Database issue):D347-54.
Pieper U, Eswar N, Webb BM, Eramian D, Kelly L, Barkan DT, Carter H, Mankoo P, Karchin R, Marti-Renom MA, Davis FP, Sali A. PMID: 18948282.
View in: PubMed Mentions: 71 Fields: Translation: HumansCells
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Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 2008 Sep 26; 321(5897):1801-6.
Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, Hong SM, Fu B, Lin MT, Calhoun ES, Kamiyama M, Walter K, Nikolskaya T, Nikolsky Y, Hartigan J, Smith DR, Hidalgo M, Leach SD, Klein AP, Jaffee EM, Goggins M, Maitra A, Iacobuzio-Donahue C, Eshleman JR, Kern SE, Hruban RH, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW. PMID: 18772397.
View in: PubMed Mentions: 1577 Fields: Translation: HumansCells
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An integrated genomic analysis of human glioblastoma multiforme. Science. 2008 Sep 26; 321(5897):1807-12.
Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Siu IM, Gallia GL, Olivi A, McLendon R, Rasheed BA, Keir S, Nikolskaya T, Nikolsky Y, Busam DA, Tekleab H, Diaz LA, Hartigan J, Smith DR, Strausberg RL, Marie SK, Shinjo SM, Yan H, Riggins GJ, Bigner DD, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW. PMID: 18772396.
View in: PubMed Mentions: 2139 Fields: Translation: HumansCells
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Year | Publications |
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2008 | 3 | 2009 | 1 | 2010 | 3 | 2011 | 4 | 2012 | 2 | 2013 | 7 | 2014 | 3 | 2015 | 2 | 2016 | 4 | 2017 | 3 | 2019 | 1 |
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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