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Louise Laurent

TitleAssociate Professor
InstitutionUniversity of California San Diego
DepartmentReproductive Medicine
Address9500 Gilman Drive #0695
La Jolla CA 92093
Phone858-246-1403
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    Collapse Research 
    Collapse Research Activities and Funding
    Magnetic nanosensors for real-time non-invasive biomarker detection in pregnancy
    NIH/NICHD R21HD094359Feb 16, 2018 - Jan 31, 2020
    Role: Principal Investigator
    Commercialization of HaploSeq as a Service (HaaS) for generating chromosome-span phased genome and exome sequence information
    NIH/NHGRI R44HG008118Mar 1, 2015 - Feb 29, 2020
    Role: Co-Principal Investigator
    Reference Profiles of ExRNAs in Normal Human Pregnancy
    NIH/NHLBI U01HL126494Aug 1, 2014 - Apr 30, 2019
    Role: Principal Investigator
    ExRNAs for Early Identification of Pregnancies at Risk for Placental Dysfunction
    NIH/NCATS UH3TR000906Aug 1, 2013 - Jul 31, 2018
    Role: Principal Investigator
    ExRNAs for Early Identification of Pregnancies at Risk for Placental Dysfunction
    NIH/NCATS UH2TR000906Aug 1, 2013 - Jul 31, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Fontcuberta-PiSunyer M, Cervantes S, Miquel E, Mora-Castilla S, Laurent L, Raya A, Gomis R, Gasa R. Modulation of the endocrine transcriptional program by targeting histone modifiers of the H3K27me3 mark. Biochim Biophys Acta. 2018 May; 1861(5):473-480. PMID: 29530603.
      View in: PubMed
    2. Dumdie JN, Cho K, Ramaiah M, Skarbrevik D, Mora-Castilla S, Stumpo DJ, Lykke-Andersen J, Laurent L, Blackshear PJ, Wilkinson MF, Cook-Andersen H. Chromatin Modification and Global Transcriptional Silencing in the Oocyte Mediated by the mRNA Decay Activator ZFP36L2. Dev Cell. 2018 Feb 05; 44(3):392-402.e7. PMID: 29408237.
      View in: PubMed
    3. Soncin F, Khater M, To C, Pizzo D, Farah O, Wakeland A, Arul Nambi Rajan K, Nelson KK, Chang CW, Moretto-Zita M, Natale DR, Laurent L, Parast MM. Comparative analysis of mouse and human placentae across gestation reveals species-specific regulators of placental development. Development. 2018 01 29; 145(2). PMID: 29361559.
      View in: PubMed
    4. Filant J, Nejad P, Paul A, Simonson B, Srinivasan S, Zhang X, Balaj L, Das S, Gandhi R, Laurent L, Sood AK. Isolation of Extracellular RNA from Serum/Plasma. Methods Mol Biol. 2018; 1740:43-57. PMID: 29388135.
      View in: PubMed
    5. Arul Nambi Rajan K, Khater M, Soncin F, Pizzo D, Moretto-Zita M, Pham J, Stus O, Iyer P, Tache V, Laurent L, Parast MM. Sirtuin1 is required for proper trophoblast differentiation and placental development in mice. Placenta. 2018 Feb; 62:1-8. PMID: 29405961.
      View in: PubMed
    6. Wing DA, Haeri S, Silber AC, Roth CK, Weiner CP, Echebiri NC, Franco A, Pappas LM, Yeast JD, Brebnor AA, Quirk JG, Murphy AM, Laurent L, Field NT, Norton ME. Placental Alpha Microglobulin-1 Compared With Fetal Fibronectin to Predict Preterm Delivery in Symptomatic Women. Obstet Gynecol. 2017 Dec; 130(6):1183-1191. PMID: 29112664.
      View in: PubMed
    7. Wakeland AK, Soncin F, Moretto-Zita M, Chang CW, Horii M, Pizzo D, Nelson KK, Laurent L, Parast MM. Hypoxia Directs Human Extravillous Trophoblast Differentiation in a Hypoxia-Inducible Factor-Dependent Manner. Am J Pathol. 2017 Apr; 187(4):767-780. PMID: 28167044.
      View in: PubMed
    8. Amir H, Touboul T, Sabatini K, Chhabra D, Garitaonandia I, Loring JF, Morey R, Laurent L. Spontaneous Single-Copy Loss of TP53 in Human Embryonic Stem Cells Markedly Increases Cell Proliferation and Survival. Stem Cells. 2017 04; 35(4):872-885. PMID: 27888558.
      View in: PubMed
    9. Albrecht C, Baker JC, Blundell C, Chavez SL, Carbone L, Chamley L, Hannibal RL, Illsley N, Kurre P, Laurent L, McKenzie C, Morales-Prieto D, Pantham P, Paquette A, Powell K, Price N, Rao BM, Sadovsky Y, Salomon C, Tuteja G, Wilson S, O'Tierney-Ginn PF. IFPA meeting 2016 workshop report I: Genomic communication, bioinformatics, trophoblast biology and transport systems. Placenta. 2017 12; 60 Suppl 1:S5-S9. PMID: 28108031.
      View in: PubMed
    10. Szabo L, Morey R, Palpant NJ, Wang PL, Afari N, Jiang C, Parast MM, Murry CE, Laurent L, Salzman J. Erratum to: Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Genome Biol. 2016 12 19; 17(1):263. PMID: 27993159.
      View in: PubMed
    11. Gonzalez R, Garitaonandia I, Poustovoitov M, Abramihina T, McEntire C, Culp B, Attwood J, Noskov A, Christiansen-Weber T, Khater M, Mora-Castilla S, To C, Crain A, Sherman G, Semechkin A, Laurent L, Elsworth JD, Sladek J, Snyder EY, Redmond DE, Kern RA. Neural Stem Cells Derived from Human Parthenogenetic Stem Cells Engraft and Promote Recovery in a Nonhuman Primate Model of Parkinson's Disease. Cell Transplant. 2016 11; 25(11):1945-1966. PMID: 27213850.
      View in: PubMed
    12. Wolf DP, Morey R, Kang E, Ma H, Hayama T, Laurent L, Mitalipov S. Concise Review: Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer: A Horse in the Race? Stem Cells. 2017 01; 35(1):26-34. PMID: 27612640.
      View in: PubMed
    13. Sheibani L, Fong A, Henry DE, Norton ME, Truong YN, Anyikam A, Laurent L, Rao R, Wing DA. Maternal and neonatal outcomes after antenatal corticosteroid administration for PPROM at 32 to 33 6/7 weeks gestational age. J Matern Fetal Neonatal Med. 2017 Jul; 30(14):1676-1680. PMID: 27578238.
      View in: PubMed
    14. Ma H, Marti Gutierrez N, Morey R, Van Dyken C, Kang E, Hayama T, Lee Y, Li Y, Tippner-Hedges R, Wolf DP, Laurent L, Mitalipov S. Incompatibility between Nuclear and Mitochondrial Genomes Contributes to an Interspecies Reproductive Barrier. Cell Metab. 2016 Aug 09; 24(2):283-94. PMID: 27425585; PMCID: PMC4981548 [Available on 08/09/17].
      View in: PubMed, PubMed Central
    15. Horii M, Li Y, Wakeland AK, Pizzo DP, Nelson KK, Sabatini K, Laurent L, Liu Y, Parast MM. Human pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):E3882-91. PMID: 27325764; PMCID: PMC4941448 [Available on 01/05/17].
      View in: PubMed, PubMed Central
    16. Lou CH, Dumdie J, Goetz A, Shum EY, Brafman D, Liao X, Mora-Castilla S, Ramaiah M, Cook-Andersen H, Laurent L, Wilkinson MF. Nonsense-Mediated RNA Decay Influences Human Embryonic Stem Cell Fate. Stem Cell Reports. 2016 06 14; 6(6):844-57. PMID: 27304915; PMCID: PMC4912386.
      View in: PubMed, PubMed Central
    17. Cheung KH, Keerthikumar S, Roncaglia P, Subramanian SL, Roth ME, Samuel M, Anand S, Gangoda L, Gould S, Alexander R, Galas D, Gerstein MB, Hill AF, Kitchen RR, Lötvall J, Patel T, Procaccini DC, Quesenberry P, Rozowsky J, Raffai RL, Shypitsyna A, Su AI, Théry C, Vickers K, Wauben MH, Mathivanan S, Milosavljevic A, Laurent L. Extending gene ontology in the context of extracellular RNA and vesicle communication. J Biomed Semantics. 2016; 7:19. PMID: 27076901; PMCID: PMC4830068.
      View in: PubMed, PubMed Central
    18. Touboul T, Chen S, To CC, Mora-Castilla S, Sabatini K, Tukey RH, Laurent L. Stage-specific regulation of the WNT/ß-catenin pathway enhances differentiation of hESCs into hepatocytes. J Hepatol. 2016 Jun; 64(6):1315-26. PMID: 26921690.
      View in: PubMed
    19. Sancho-Martinez I, Nivet E, Xia Y, Hishida T, Aguirre A, Ocampo A, Ma L, Morey R, Krause MN, Zembrzycki A, Ansorge O, Vazquez-Ferrer E, Dubova I, Reddy P, Lam D, Hishida Y, Wu MZ, Esteban CR, O'Leary D, Wahl GM, Verma IM, Laurent L, Izpisua Belmonte JC. Establishment of human iPSC-based models for the study and targeting of glioma initiating cells. Nat Commun. 2016 Feb 22; 7:10743. PMID: 26899176; PMCID: PMC4764898.
      View in: PubMed, PubMed Central
    20. Mora-Castilla S, To C, Vaezeslami S, Morey R, Srinivasan S, Dumdie JN, Cook-Andersen H, Jenkins J, Laurent L. Miniaturization Technologies for Efficient Single-Cell Library Preparation for Next-Generation Sequencing. J Lab Autom. 2016 Aug; 21(4):557-67. PMID: 26891732; PMCID: PMC4948133.
      View in: PubMed, PubMed Central
    21. Leon-Garcia SM, Roeder HA, Nelson KK, Liao X, Pizzo DP, Laurent L, Parast MM, LaCoursiere DY. Maternal obesity and sex-specific differences in placental pathology. Placenta. 2016 Feb; 38:33-40. PMID: 26907380.
      View in: PubMed
    22. Machtinger R, Laurent L, Baccarelli AA. Extracellular vesicles: roles in gamete maturation, fertilization and embryo implantation. Hum Reprod Update. 2016 Mar-Apr; 22(2):182-93. PMID: 26663221.
      View in: PubMed
    23. Zdravkovic T, Nazor KL, Larocque N, Gormley M, Donne M, Hunkapillar N, Giritharan G, Bernstein HS, Wei G, Hebrok M, Zeng X, Genbacev O, Mattis A, McMaster MT, Krtolica A, Valbuena D, Simón C, Laurent L, Loring JF, Fisher SJ. Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification. Development. 2015 Dec 01; 142(23):4010-25. PMID: 26483210; PMCID: PMC4712832.
      View in: PubMed, PubMed Central
    24. Subramanian SL, Kitchen RR, Alexander R, Carter BS, Cheung KH, Laurent L, Pico A, Roberts LR, Roth ME, Rozowsky JS, Su AI, Gerstein MB, Milosavljevic A. Integration of extracellular RNA profiling data using metadata, biomedical ontologies and Linked Data technologies. J Extracell Vesicles. 2015; 4:27497. PMID: 26320941; PMCID: PMC4553261.
      View in: PubMed, PubMed Central
    25. Quinn JF, Patel T, Wong D, Das S, Freedman JE, Laurent L, Carter BS, Hochberg F, Van Keuren-Jensen K, Huentelman M, Spetzler R, Kalani MY, Arango J, Adelson PD, Weiner HL, Gandhi R, Goilav B, Putterman C, Saugstad JA. Extracellular RNAs: development as biomarkers of human disease. J Extracell Vesicles. 2015; 4:27495. PMID: 26320940; PMCID: PMC4553262.
      View in: PubMed, PubMed Central
    26. Laurent L, Abdel-Mageed AB, Adelson PD, Arango J, Balaj L, Breakefield X, Carlson E, Carter BS, Majem B, Chen CC, Cocucci E, Danielson K, Courtright A, Das S, Abd Elmageed ZY, Enderle D, Ezrin A, Ferrer M, Freedman J, Galas D, Gandhi R, Huentelman MJ, Van Keuren-Jensen K, Kalani Y, Kim Y, Krichevsky AM, Lai C, Lal-Nag M, Laurent CD, Leonardo T, Li F, Malenica I, Mondal D, Nejad P, Patel T, Raffai RL, Rubio R, Skog J, Spetzler R, Sun J, Tanriverdi K, Vickers K, Wang L, Wang Y, Wei Z, Weiner HL, Wong D, Yan IK, Yeri A, Gould S. Meeting report: discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium. J Extracell Vesicles. 2015; 4:26533. PMID: 26320937; PMCID: PMC4553263.
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    27. Ma H, Folmes CD, Wu J, Morey R, Mora-Castilla S, Ocampo A, Ma L, Poulton J, Wang X, Ahmed R, Kang E, Lee Y, Hayama T, Li Y, Van Dyken C, Gutierrez NM, Tippner-Hedges R, Koski A, Mitalipov N, Amato P, Wolf DP, Huang T, Terzic A, Laurent L, Izpisua Belmonte JC, Mitalipov S. Metabolic rescue in pluripotent cells from patients with mtDNA disease. Nature. 2015 Aug 13; 524(7564):234-8. PMID: 26176921.
      View in: PubMed
    28. Gallego Romero I, Pavlovic BJ, Hernando-Herraez I, Zhou X, Ward MC, Banovich NE, Kagan CL, Burnett JE, Huang CH, Mitrano A, Chavarria CI, Friedrich Ben-Nun I, Li Y, Sabatini K, Leonardo TR, Parast M, Marques-Bonet T, Laurent L, Loring JF, Gilad Y. A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics. Elife. 2015 Jun 23; 4:e07103. PMID: 26102527; PMCID: PMC4502404.
      View in: PubMed, PubMed Central
    29. Szabo L, Morey R, Palpant NJ, Wang PL, Afari N, Jiang C, Parast MM, Murry CE, Laurent L, Salzman J. Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Genome Biol. 2015 Jun 16; 16:126. PMID: 26076956; PMCID: PMC4506483.
      View in: PubMed, PubMed Central
    30. Norton ME, Jacobsson B, Swamy GK, Laurent L, Ranzini AC, Brar H, Tomlinson MW, Pereira L, Spitz JL, Hollemon D, Cuckle H, Musci TJ, Wapner RJ. Cell-free DNA analysis for noninvasive examination of trisomy. N Engl J Med. 2015 Apr 23; 372(17):1589-97. PMID: 25830321.
      View in: PubMed
    31. Lahmy R, Bolyukh VF, Castilla SM, Laurent L, Katkov II, Itkin-Ansari P. Tolerance of human embryonic stem cell derived islet progenitor cells to vitrification-relevant solutions. Cryobiology. 2015 Jun; 70(3):283-6. PMID: 25817378.
      View in: PubMed
    32. Gonzalez R, Garitaonandia I, Crain A, Poustovoitov M, Abramihina T, Noskov A, Jiang C, Morey R, Laurent L, Elsworth JD, Snyder EY, Redmond DE, Semechkin R. Proof of concept studies exploring the safety and functional activity of human parthenogenetic-derived neural stem cells for the treatment of Parkinson's disease. Cell Transplant. 2015; 24(4):681-90. PMID: 25839189.
      View in: PubMed
    33. Garitaonandia I, Amir H, Boscolo FS, Wambua GK, Schultheisz HL, Sabatini K, Morey R, Waltz S, Wang YC, Tran H, Leonardo TR, Nazor K, Slavin I, Lynch C, Li Y, Coleman R, Gallego Romero I, Altun G, Reynolds D, Dalton S, Parast M, Loring JF, Laurent L. Increased risk of genetic and epigenetic instability in human embryonic stem cells associated with specific culture conditions. PLoS One. 2015; 10(2):e0118307. PMID: 25714340.
      View in: PubMed
    34. Roeder HA, Dejbakhsh SZ, Parast MM, Laurent L, Woelkers DA. Abnormal uterine artery Doppler velocimetry predicts adverse outcomes in patients with abnormal analytes. Pregnancy Hypertens. 2014 Oct; 4(4):296-301. PMID: 26104819.
      View in: PubMed
    35. Chen C, Jiang P, Xue H, Peterson SE, Tran HT, McCann AE, Parast MM, Li S, Pleasure DE, Laurent L, Loring JF, Liu Y, Deng W. Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells. Nat Commun. 2014 Jul 18; 5:4430. PMID: 25034944; PMCID: PMC4109022.
      View in: PubMed, PubMed Central
    36. Ma H, Morey R, O'Neil RC, He Y, Daughtry B, Schultz MD, Hariharan M, Nery JR, Castanon R, Sabatini K, Thiagarajan RD, Tachibana M, Kang E, Tippner-Hedges R, Ahmed R, Gutierrez NM, Van Dyken C, Polat A, Sugawara A, Sparman M, Gokhale S, Amato P, Wolf DP, Ecker JR, Laurent L, Mitalipov S. Abnormalities in human pluripotent cells due to reprogramming mechanisms. Nature. 2014 Jul 10; 511(7508):177-83. PMID: 25008523; PMCID: PMC4898064.
      View in: PubMed, PubMed Central
    37. Benitah SA, Bracken A, Dou Y, Huangfu D, Ivanova N, Koseki H, Laurent L, Lim DA, Meshorer E, Pombo A, Sander M, Xu GL. Stem cell epigenetics: looking forward. Cell Stem Cell. 2014 Jun 05; 14(6):706-9. PMID: 25032261.
      View in: PubMed
    38. Morey R, Laurent L. Getting off the ground state: X chromosome inactivation knocks down barriers to differentiation. Cell Stem Cell. 2014 Feb 06; 14(2):131-2. PMID: 24506876; PMCID: PMC3984128.
      View in: PubMed, PubMed Central
    39. Thiagarajan RD, Morey R, Laurent L. The epigenome in pluripotency and differentiation. Epigenomics. 2014 Feb; 6(1):121-37. PMID: 24579950.
      View in: PubMed
    40. Ben-Yosef D, Boscolo FS, Amir H, Malcov M, Amit A, Laurent L. Genomic analysis of hESC pedigrees identifies de novo mutations and enables determination of the timing and origin of mutational events. Cell Rep. 2013 Sep 26; 4(6):1288-302. PMID: 24035391; PMCID: PMC3894204.
      View in: PubMed, PubMed Central
    41. Li Y, Moretto-Zita M, Soncin F, Wakeland A, Wolfe L, Leon-Garcia S, Pandian R, Pizzo D, Cui L, Nazor K, Loring JF, Crum CP, Laurent L, Parast MM. BMP4-directed trophoblast differentiation of human embryonic stem cells is mediated through a ?Np63+ cytotrophoblast stem cell state. Development. 2013 Oct; 140(19):3965-76. PMID: 24004950; PMCID: PMC3775414.
      View in: PubMed, PubMed Central
    42. Liao X, Xue H, Wang YC, Nazor KL, Guo S, Trivedi N, Peterson SE, Liu Y, Loring JF, Laurent L. Matched miRNA and mRNA signatures from an hESC-based in vitro model of pancreatic differentiation reveal novel regulatory interactions. J Cell Sci. 2013 Sep 01; 126(Pt 17):3848-61. PMID: 23813959; PMCID: PMC3757328.
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    43. Jones JC, Sabatini K, Liao X, Tran HT, Lynch CL, Morey RE, Glenn-Pratola V, Boscolo FS, Yang Q, Parast MM, Liu Y, Peterson SE, Laurent L, Loring JF, Wang YC. Melanocytes derived from transgene-free human induced pluripotent stem cells. J Invest Dermatol. 2013 Aug; 133(8):2104-8. PMID: 23514962; PMCID: PMC3714355.
      View in: PubMed, PubMed Central
    44. Gonzalez R, Garitaonandia I, Abramihina T, Wambua GK, Ostrowska A, Brock M, Noskov A, Boscolo FS, Craw JS, Laurent L, Snyder EY, Semechkin RA. Deriving dopaminergic neurons for clinical use. A practical approach. Sci Rep. 2013; 3:1463. PMID: 23492920; PMCID: PMC3597995.
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    45. Kurian L, Sancho-Martinez I, Nivet E, Aguirre A, Moon K, Pendaries C, Volle-Challier C, Bono F, Herbert JM, Pulecio J, Xia Y, Li M, Montserrat N, Ruiz S, Dubova I, Rodriguez C, Denli AM, Boscolo FS, Thiagarajan RD, Gage FH, Loring JF, Laurent L, Izpisua Belmonte JC. Conversion of human fibroblasts to angioblast-like progenitor cells. Nat Methods. 2013 Jan; 10(1):77-83. PMID: 23202434; PMCID: PMC3531579.
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    46. Leonardo TR, Schultheisz HL, Loring JF, Laurent L. The functions of microRNAs in pluripotency and reprogramming. Nat Cell Biol. 2012 Nov; 14(11):1114-21. PMID: 23131918.
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    47. Nazor KL, Loring JF, Laurent L. Equally potent? Does cellular reprogramming justify the abandonment of human embryonic stem cells? EMBO Rep. 2012 Oct; 13(10):890-4. PMID: 22986548; PMCID: PMC3463969.
      View in: PubMed, PubMed Central
    48. Ramsköld D, Luo S, Wang YC, Li R, Deng Q, Faridani OR, Daniels GA, Khrebtukova I, Loring JF, Laurent L, Schroth GP, Sandberg R. Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells. Nat Biotechnol. 2012 Aug; 30(8):777-82. PMID: 22820318; PMCID: PMC3467340.
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    49. Norton ME, Brar H, Weiss J, Karimi A, Laurent L, Caughey AB, Rodriguez MH, Williams J, Mitchell ME, Adair CD, Lee H, Jacobsson B, Tomlinson MW, Oepkes D, Hollemon D, Sparks AB, Oliphant A, Song K. Non-Invasive Chromosomal Evaluation (NICE) Study: results of a multicenter prospective cohort study for detection of fetal trisomy 21 and trisomy 18. Am J Obstet Gynecol. 2012 Aug; 207(2):137.e1-8. PMID: 22742782.
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    50. Nazor KL, Altun G, Lynch C, Tran H, Harness JV, Slavin I, Garitaonandia I, Müller FJ, Wang YC, Boscolo FS, Fakunle E, Dumevska B, Lee S, Park HS, Olee T, D'Lima DD, Semechkin R, Parast MM, Galat V, Laslett AL, Schmidt U, Keirstead HS, Loring JF, Laurent L. Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives. Cell Stem Cell. 2012 May 04; 10(5):620-34. PMID: 22560082; PMCID: PMC3348513.
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    51. Liao WX, Laurent L, Agent S, Hodges J, Chen DB. Human placental expression of SLIT/ROBO signaling cues: effects of preeclampsia and hypoxia. Biol Reprod. 2012 Apr; 86(4):111. PMID: 22262697; PMCID: PMC3338657.
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    52. Wang W, Feng L, Zhang H, Hachy S, Satohisa S, Laurent L, Parast M, Zheng J, Chen DB. Preeclampsia up-regulates angiogenesis-associated microRNA (i.e., miR-17, -20a, and -20b) that target ephrin-B2 and EPHB4 in human placenta. J Clin Endocrinol Metab. 2012 Jun; 97(6):E1051-9. PMID: 22438230; PMCID: PMC3387422.
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    53. Fan JB, Chen J, April CS, Fisher JS, Klotzle B, Bibikova M, Kaper F, Ronaghi M, Linnarsson S, Ota T, Chien J, Laurent L, Loring JF, Nisperos SV, Chen GY, Zhong JF. Highly parallel genome-wide expression analysis of single mammalian cells. PLoS One. 2012; 7(2):e30794. PMID: 22347404; PMCID: PMC3275609.
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    54. Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent L, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LS. Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature. 2012 Jan 25; 482(7384):216-20. PMID: 22278060; PMCID: PMC3338985.
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    55. Peterson SE, Tran HT, Garitaonandia I, Han S, Nickey KS, Leonardo T, Laurent L, Loring JF. Teratoma generation in the testis capsule. J Vis Exp. 2011 Nov 07; (57):e3177. PMID: 22158256; PMCID: PMC3308584.
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    56. Wang YC, Nakagawa M, Garitaonandia I, Slavin I, Altun G, Lacharite RM, Nazor KL, Tran HT, Lynch CL, Leonardo TR, Liu Y, Peterson SE, Laurent L, Yamanaka S, Loring JF. Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis. Cell Res. 2011 Nov; 21(11):1551-63. PMID: 21894191; PMCID: PMC3364725.
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    57. Ben-Nun IF, Montague SC, Houck ML, Tran HT, Garitaonandia I, Leonardo TR, Wang YC, Charter SJ, Laurent L, Ryder OA, Loring JF. Induced pluripotent stem cells from highly endangered species. Nat Methods. 2011 Sep 04; 8(10):829-31. PMID: 21892153.
      View in: PubMed
    58. Golob JL, Kumar RM, Guenther MG, Pabon LM, Pratt GA, Loring JF, Laurent L, Young RA, Murry CE. Evidence that gene activation and silencing during stem cell differentiation requires a transcriptionally paused intermediate state. PLoS One. 2011; 6(8):e22416. PMID: 21886766; PMCID: PMC3158746.
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    59. Peterson SE, Westra JW, Rehen SK, Young H, Bushman DM, Paczkowski CM, Yung YC, Lynch CL, Tran HT, Nickey KS, Wang YC, Laurent L, Loring JF, Carpenter MK, Chun J. Normal human pluripotent stem cell lines exhibit pervasive mosaic aneuploidy. PLoS One. 2011; 6(8):e23018. PMID: 21857983; PMCID: PMC3156708.
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    60. Macarthur CC, Xue H, Van Hoof D, Lieu PT, Dudas M, Fontes A, Swistowski A, Touboul T, Seerke R, Laurent L, Loring JF, German MS, Zeng X, Rao MS, Lakshmipathy U, Chesnut JD, Liu Y. Chromatin insulator elements block transgene silencing in engineered human embryonic stem cell lines at a defined chromosome 13 locus. Stem Cells Dev. 2012 Jan 20; 21(2):191-205. PMID: 21699412; PMCID: PMC3258440.
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    61. Ruff D, MacArthur C, Tran H, Bergseid J, Tian J, Shannon M, Chen SM, Fontes A, Laurent L, Swartzman E, Taliana A, Rao M, Lieu PT. Applications of quantitative polymerase chain reaction protein assays during reprogramming. Stem Cells Dev. 2012 Mar 01; 21(4):530-8. PMID: 21476854.
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    62. Liu GH, Suzuki K, Qu J, Sancho-Martinez I, Yi F, Li M, Kumar S, Nivet E, Kim J, Soligalla RD, Dubova I, Goebl A, Plongthongkum N, Fung HL, Zhang K, Loring JF, Laurent L, Izpisua Belmonte JC. Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs. Cell Stem Cell. 2011 Jun 03; 8(6):688-94. PMID: 21596650; PMCID: PMC3480729.
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    63. Müller FJ, Schuldt BM, Williams R, Mason D, Altun G, Papapetrou EP, Danner S, Goldmann JE, Herbst A, Schmidt NO, Aldenhoff JB, Laurent L, Loring JF. A bioinformatic assay for pluripotency in human cells. Nat Methods. 2011 Apr; 8(4):315-7. PMID: 21378979; PMCID: PMC3265323.
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    64. Laurent L, Ulitsky I, Slavin I, Tran H, Schork A, Morey R, Lynch C, Harness JV, Lee S, Barrero MJ, Ku S, Martynova M, Semechkin R, Galat V, Gottesfeld J, Izpisua Belmonte JC, Murry C, Keirstead HS, Park HS, Schmidt U, Laslett AL, Muller FJ, Nievergelt CM, Shamir R, Loring JF. Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell Stem Cell. 2011 Jan 07; 8(1):106-18. PMID: 21211785; PMCID: PMC3043464.
      View in: PubMed, PubMed Central
    65. Harness JV, Turovets NA, Seiler MJ, Nistor G, Altun G, Agapova LS, Ferguson D, Laurent L, Loring JF, Keirstead HS. Equivalence of conventionally-derived and parthenote-derived human embryonic stem cells. PLoS One. 2011 Jan 07; 6(1):e14499. PMID: 21249129; PMCID: PMC3017547.
      View in: PubMed, PubMed Central
    66. Ku S, Soragni E, Campau E, Thomas EA, Altun G, Laurent L, Loring JF, Napierala M, Gottesfeld JM. Friedreich's ataxia induced pluripotent stem cells model intergenerational GAA·TTC triplet repeat instability. Cell Stem Cell. 2010 Nov 05; 7(5):631-7. PMID: 21040903; PMCID: PMC2987635.
      View in: PubMed, PubMed Central
    67. Ulitsky I, Laurent L, Shamir R. Towards computational prediction of microRNA function and activity. Nucleic Acids Res. 2010 Aug; 38(15):e160. PMID: 20576699; PMCID: PMC2926627.
      View in: PubMed, PubMed Central
    68. Laurent L, Wong E, Li G, Huynh T, Tsirigos A, Ong CT, Low HM, Kin Sung KW, Rigoutsos I, Loring J, Wei CL. Dynamic changes in the human methylome during differentiation. Genome Res. 2010 Mar; 20(3):320-31. PMID: 20133333; PMCID: PMC2840979.
      View in: PubMed, PubMed Central
    69. Abraham S, Sheridan SD, Laurent L, Albert K, Stubban C, Ulitsky I, Miller B, Loring JF, Rao RR. Propagation of human embryonic and induced pluripotent stem cells in an indirect co-culture system. Biochem Biophys Res Commun. 2010 Mar 05; 393(2):211-6. PMID: 20117095; PMCID: PMC2834855.
      View in: PubMed, PubMed Central
    70. Laurent L, Nievergelt CM, Lynch C, Fakunle E, Harness JV, Schmidt U, Galat V, Laslett AL, Otonkoski T, Keirstead HS, Schork A, Park HS, Loring JF. Restricted ethnic diversity in human embryonic stem cell lines. Nat Methods. 2010 Jan; 7(1):6-7. PMID: 20038950.
      View in: PubMed
    71. Altun G, Loring JF, Laurent L. DNA methylation in embryonic stem cells. J Cell Biochem. 2010 Jan 01; 109(1):1-6. PMID: 19899110; PMCID: PMC3289679.
      View in: PubMed, PubMed Central
    72. Laurent L. MicroRNAs in embryonic stem cells and early embryonic development. J Cell Mol Med. 2008 Dec; 12(6A):2181-8. PMID: 19120702; PMCID: PMC4514098.
      View in: PubMed, PubMed Central
    73. Müller FJ, Laurent L, Kostka D, Ulitsky I, Williams R, Lu C, Park IH, Rao MS, Shamir R, Schwartz PH, Schmidt NO, Loring JF. Regulatory networks define phenotypic classes of human stem cell lines. Nature. 2008 Sep 18; 455(7211):401-5. PMID: 18724358; PMCID: PMC2637443.
      View in: PubMed, PubMed Central
    74. Laurent L, Chen J, Ulitsky I, Mueller FJ, Lu C, Shamir R, Fan JB, Loring JF. Comprehensive microRNA profiling reveals a unique human embryonic stem cell signature dominated by a single seed sequence. Stem Cells. 2008 Jun; 26(6):1506-16. PMID: 18403753.
      View in: PubMed
    75. Bibikova M, Laurent L, Ren B, Loring JF, Fan JB. Unraveling epigenetic regulation in embryonic stem cells. Cell Stem Cell. 2008 Feb 07; 2(2):123-34. PMID: 18371433.
      View in: PubMed
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