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    Louise Laurent

    TitleAssociate Professor
    SchoolUniversity of California, San Diego
    DepartmentReproductive Medicine
    Address9500 Gilman Drive #0695
    CA La Jolla 92093
    Phone858-246-1403
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Magnetic nanosensors for real-time non-invasive biomarker detection in pregnancy
      NIH/NICHD R21HD094359Feb 16, 2018 - Jan 31, 2020
      Role: Principal Investigator
      Commercialization of HaploSeq as a Service (HaaS) for generating chromosome-span phased genome and exome sequence information
      NIH/NHGRI R44HG008118Mar 1, 2015 - Feb 29, 2020
      Role: Co-Principal Investigator
      Reference Profiles of ExRNAs in Normal Human Pregnancy
      NIH/NHLBI U01HL126494Aug 1, 2014 - Apr 30, 2019
      Role: Principal Investigator
      ExRNAs for Early Identification of Pregnancies at Risk for Placental Dysfunction
      NIH/NCATS UH3TR000906Aug 1, 2013 - Jul 31, 2018
      Role: Principal Investigator
      ExRNAs for Early Identification of Pregnancies at Risk for Placental Dysfunction
      NIH/NCATS UH2TR000906Aug 1, 2013 - Jul 31, 2015
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Soncin F, Khater M, To C, Pizzo D, Farah O, Wakeland A, Arul Nambi Rajan K, Nelson KK, Chang CW, Moretto-Zita M, Natale DR, Laurent L, Parast MM. Comparative analysis of mouse and human placentae across gestation reveals species-specific regulators of placental development. Development. 2018 01 29; 145(2). PMID: 29361559.
        View in: PubMed
      2. Wakeland AK, Soncin F, Moretto-Zita M, Chang CW, Horii M, Pizzo D, Nelson KK, Laurent L, Parast MM. Hypoxia Directs Human Extravillous Trophoblast Differentiation in a Hypoxia-Inducible Factor-Dependent Manner. Am J Pathol. 2017 Apr; 187(4):767-780. PMID: 28167044.
        View in: PubMed
      3. Amir H, Touboul T, Sabatini K, Chhabra D, Garitaonandia I, Loring JF, Morey R, Laurent L. Spontaneous Single-Copy Loss of TP53 in Human Embryonic Stem Cells Markedly Increases Cell Proliferation and Survival. Stem Cells. 2017 Apr; 35(4):872-885. PMID: 27888558.
        View in: PubMed
      4. Szabo L, Morey R, Palpant NJ, Wang PL, Afari N, Jiang C, Parast MM, Murry CE, Laurent L, Salzman J. Erratum to: Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Genome Biol. 2016 Dec 19; 17(1):263. PMID: 27993159.
        View in: PubMed
      5. Gonzalez R, Garitaonandia I, Poustovoitov M, Abramihina T, McEntire C, Culp B, Attwood J, Noskov A, Christiansen-Weber T, Khater M, Mora-Castilla S, To C, Crain A, Sherman G, Semechkin A, Laurent L, Elsworth JD, Sladek J, Snyder EY, Redmond DE, Kern RA. Neural Stem Cells Derived from Human Parthenogenetic Stem Cells Engraft and Promote Recovery in a Nonhuman Primate Model of Parkinson's Disease. Cell Transplant. 2016 Nov; 25(11):1945-1966. PMID: 27213850.
        View in: PubMed
      6. Wolf DP, Morey R, Kang E, Ma H, Hayama T, Laurent L, Mitalipov S. Concise Review: Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer: A Horse in the Race? Stem Cells. 2017 Jan; 35(1):26-34. PMID: 27612640.
        View in: PubMed
      7. Sheibani L, Fong A, Henry DE, Norton ME, Truong YN, Anyikam A, Laurent L, Rao R, Wing DA. Maternal and neonatal outcomes after antenatal corticosteroid administration for PPROM at 32 to 33 6/7 weeks gestational age. J Matern Fetal Neonatal Med. 2017 Jul; 30(14):1676-1680. PMID: 27578238.
        View in: PubMed
      8. Ma H, Marti Gutierrez N, Morey R, Van Dyken C, Kang E, Hayama T, Lee Y, Li Y, Tippner-Hedges R, Wolf DP, Laurent L, Mitalipov S. Incompatibility between Nuclear and Mitochondrial Genomes Contributes to an Interspecies Reproductive Barrier. Cell Metab. 2016 Aug 09; 24(2):283-94. PMID: 27425585; PMCID: PMC4981548 [Available on 08/09/17].
        View in: PubMed, PubMed Central
      9. Horii M, Li Y, Wakeland AK, Pizzo DP, Nelson KK, Sabatini K, Laurent L, Liu Y, Parast MM. Human pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):E3882-91. PMID: 27325764; PMCID: PMC4941448 [Available on 01/05/17].
        View in: PubMed, PubMed Central
      10. Lou CH, Dumdie J, Goetz A, Shum EY, Brafman D, Liao X, Mora-Castilla S, Ramaiah M, Cook-Andersen H, Laurent L, Wilkinson MF. Nonsense-Mediated RNA Decay Influences Human Embryonic Stem Cell Fate. Stem Cell Reports. 2016 Jun 14; 6(6):844-57. PMID: 27304915; PMCID: PMC4912386.
        View in: PubMed, PubMed Central
      11. Cheung KH, Keerthikumar S, Roncaglia P, Subramanian SL, Roth ME, Samuel M, Anand S, Gangoda L, Gould S, Alexander R, Galas D, Gerstein MB, Hill AF, Kitchen RR, Lötvall J, Patel T, Procaccini DC, Quesenberry P, Rozowsky J, Raffai RL, Shypitsyna A, Su AI, Théry C, Vickers K, Wauben MH, Mathivanan S, Milosavljevic A, Laurent L. Extending gene ontology in the context of extracellular RNA and vesicle communication. J Biomed Semantics. 2016; 7:19. PMID: 27076901; PMCID: PMC4830068.
        View in: PubMed, PubMed Central
      12. Touboul T, Chen S, To CC, Mora-Castilla S, Sabatini K, Tukey RH, Laurent L. Stage-specific regulation of the WNT/ß-catenin pathway enhances differentiation of hESCs into hepatocytes. J Hepatol. 2016 Jun; 64(6):1315-26. PMID: 26921690; PMCID: PMC5010388.
        View in: PubMed, PubMed Central
      13. Sancho-Martinez I, Nivet E, Xia Y, Hishida T, Aguirre A, Ocampo A, Ma L, Morey R, Krause MN, Zembrzycki A, Ansorge O, Vazquez-Ferrer E, Dubova I, Reddy P, Lam D, Hishida Y, Wu MZ, Esteban CR, O'Leary D, Wahl GM, Verma IM, Laurent L, Izpisua Belmonte JC. Establishment of human iPSC-based models for the study and targeting of glioma initiating cells. Nat Commun. 2016 Feb 22; 7:10743. PMID: 26899176; PMCID: PMC4764898.
        View in: PubMed, PubMed Central
      14. Mora-Castilla S, To C, Vaezeslami S, Morey R, Srinivasan S, Dumdie JN, Cook-Andersen H, Jenkins J, Laurent L. Miniaturization Technologies for Efficient Single-Cell Library Preparation for Next-Generation Sequencing. J Lab Autom. 2016 Aug; 21(4):557-67. PMID: 26891732; PMCID: PMC4948133.
        View in: PubMed, PubMed Central
      15. Leon-Garcia SM, Roeder HA, Nelson KK, Liao X, Pizzo DP, Laurent L, Parast MM, LaCoursiere DY. Maternal obesity and sex-specific differences in placental pathology. Placenta. 2016 Feb; 38:33-40. PMID: 26907380.
        View in: PubMed
      16. Machtinger R, Laurent L, Baccarelli AA. Extracellular vesicles: roles in gamete maturation, fertilization and embryo implantation. Hum Reprod Update. 2016 Mar-Apr; 22(2):182-93. PMID: 26663221; PMCID: PMC4755440 [Available on 03/01/17].
        View in: PubMed, PubMed Central
      17. Zdravkovic T, Nazor KL, Larocque N, Gormley M, Donne M, Hunkapillar N, Giritharan G, Bernstein HS, Wei G, Hebrok M, Zeng X, Genbacev O, Mattis A, McMaster MT, Krtolica A, Valbuena D, Simón C, Laurent L, Loring JF, Fisher SJ. Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification. Development. 2015 Dec 01; 142(23):4010-25. PMID: 26483210; PMCID: PMC4712832.
        View in: PubMed, PubMed Central
      18. Subramanian SL, Kitchen RR, Alexander R, Carter BS, Cheung KH, Laurent L, Pico A, Roberts LR, Roth ME, Rozowsky JS, Su AI, Gerstein MB, Milosavljevic A. Integration of extracellular RNA profiling data using metadata, biomedical ontologies and Linked Data technologies. J Extracell Vesicles. 2015; 4:27497. PMID: 26320941; PMCID: PMC4553261.
        View in: PubMed, PubMed Central
      19. Laurent L, Abdel-Mageed AB, Adelson PD, Arango J, Balaj L, Breakefield X, Carlson E, Carter BS, Majem B, Chen CC, Cocucci E, Danielson K, Courtright A, Das S, Abd Elmageed ZY, Enderle D, Ezrin A, Ferrer M, Freedman J, Galas D, Gandhi R, Huentelman MJ, Van Keuren-Jensen K, Kalani Y, Kim Y, Krichevsky AM, Lai C, Lal-Nag M, Laurent CD, Leonardo T, Li F, Malenica I, Mondal D, Nejad P, Patel T, Raffai RL, Rubio R, Skog J, Spetzler R, Sun J, Tanriverdi K, Vickers K, Wang L, Wang Y, Wei Z, Weiner HL, Wong D, Yan IK, Yeri A, Gould S. Meeting report: discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium. J Extracell Vesicles. 2015; 4:26533. PMID: 26320937; PMCID: PMC4553263.
        View in: PubMed, PubMed Central
      20. Quinn JF, Patel T, Wong D, Das S, Freedman JE, Laurent L, Carter BS, Hochberg F, Van Keuren-Jensen K, Huentelman M, Spetzler R, Kalani MY, Arango J, Adelson PD, Weiner HL, Gandhi R, Goilav B, Putterman C, Saugstad JA. Extracellular RNAs: development as biomarkers of human disease. J Extracell Vesicles. 2015; 4:27495. PMID: 26320940; PMCID: PMC4553262.
        View in: PubMed, PubMed Central
      21. Ma H, Folmes CD, Wu J, Morey R, Mora-Castilla S, Ocampo A, Ma L, Poulton J, Wang X, Ahmed R, Kang E, Lee Y, Hayama T, Li Y, Van Dyken C, Gutierrez NM, Tippner-Hedges R, Koski A, Mitalipov N, Amato P, Wolf DP, Huang T, Terzic A, Laurent L, Izpisua Belmonte JC, Mitalipov S. Metabolic rescue in pluripotent cells from patients with mtDNA disease. Nature. 2015 Aug 13; 524(7564):234-8. PMID: 26176921.
        View in: PubMed
      22. Gallego Romero I, Pavlovic BJ, Hernando-Herraez I, Zhou X, Ward MC, Banovich NE, Kagan CL, Burnett JE, Huang CH, Mitrano A, Chavarria CI, Friedrich Ben-Nun I, Li Y, Sabatini K, Leonardo TR, Parast M, Marques-Bonet T, Laurent L, Loring JF, Gilad Y. A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics. Elife. 2015 Jun 23; 4:e07103. PMID: 26102527; PMCID: PMC4502404.
        View in: PubMed, PubMed Central
      23. Szabo L, Morey R, Palpant NJ, Wang PL, Afari N, Jiang C, Parast MM, Murry CE, Laurent L, Salzman J. Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Genome Biol. 2015 Jun 16; 16:126. PMID: 26076956; PMCID: PMC4506483.
        View in: PubMed, PubMed Central
      24. Norton ME, Jacobsson B, Swamy GK, Laurent L, Ranzini AC, Brar H, Tomlinson MW, Pereira L, Spitz JL, Hollemon D, Cuckle H, Musci TJ, Wapner RJ. Cell-free DNA analysis for noninvasive examination of trisomy. N Engl J Med. 2015 Apr 23; 372(17):1589-97. PMID: 25830321.
        View in: PubMed
      25. Lahmy R, Bolyukh VF, Castilla SM, Laurent L, Katkov II, Itkin-Ansari P. Tolerance of human embryonic stem cell derived islet progenitor cells to vitrification-relevant solutions. Cryobiology. 2015 Jun; 70(3):283-6. PMID: 25817378.
        View in: PubMed
      26. Gonzalez R, Garitaonandia I, Crain A, Poustovoitov M, Abramihina T, Noskov A, Jiang C, Morey R, Laurent L, Elsworth JD, Snyder EY, Redmond DE, Semechkin R. Proof of concept studies exploring the safety and functional activity of human parthenogenetic-derived neural stem cells for the treatment of Parkinson's disease. Cell Transplant. 2015; 24(4):681-90. PMID: 25839189.
        View in: PubMed
      27. Garitaonandia I, Amir H, Boscolo FS, Wambua GK, Schultheisz HL, Sabatini K, Morey R, Waltz S, Wang YC, Tran H, Leonardo TR, Nazor K, Slavin I, Lynch C, Li Y, Coleman R, Gallego Romero I, Altun G, Reynolds D, Dalton S, Parast M, Loring JF, Laurent L. Increased risk of genetic and epigenetic instability in human embryonic stem cells associated with specific culture conditions. PLoS One. 2015; 10(2):e0118307. PMID: 25714340; PMCID: PMC4340884.
        View in: PubMed, PubMed Central
      28. Roeder HA, Dejbakhsh SZ, Parast MM, Laurent L, Woelkers DA. Abnormal uterine artery Doppler velocimetry predicts adverse outcomes in patients with abnormal analytes. Pregnancy Hypertens. 2014 Oct; 4(4):296-301. PMID: 26104819.
        View in: PubMed
      29. Chen C, Jiang P, Xue H, Peterson SE, Tran HT, McCann AE, Parast MM, Li S, Pleasure DE, Laurent L, Loring JF, Liu Y, Deng W. Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells. Nat Commun. 2014 Jul 18; 5:4430. PMID: 25034944; PMCID: PMC4109022.
        View in: PubMed, PubMed Central
      30. Ma H, Morey R, O'Neil RC, He Y, Daughtry B, Schultz MD, Hariharan M, Nery JR, Castanon R, Sabatini K, Thiagarajan RD, Tachibana M, Kang E, Tippner-Hedges R, Ahmed R, Gutierrez NM, Van Dyken C, Polat A, Sugawara A, Sparman M, Gokhale S, Amato P, Wolf DP, Ecker JR, Laurent L, Mitalipov S. Abnormalities in human pluripotent cells due to reprogramming mechanisms. Nature. 2014 Jul 10; 511(7508):177-83. PMID: 25008523; PMCID: PMC4898064.
        View in: PubMed, PubMed Central
      31. Wolfe LM, Thiagarajan RD, Boscolo F, Taché V, Coleman RL, Kim J, Kwan WK, Loring JF, Parast M, Laurent L. Banking placental tissue: an optimized collection procedure for genome-wide analysis of nucleic acids. Placenta. 2014 Aug; 35(8):645-54. PMID: 24951174; PMCID: PMC4847722.
        View in: PubMed, PubMed Central
      32. Benitah SA, Bracken A, Dou Y, Huangfu D, Ivanova N, Koseki H, Laurent L, Lim DA, Meshorer E, Pombo A, Sander M, Xu GL. Stem cell epigenetics: looking forward. Cell Stem Cell. 2014 Jun 05; 14(6):706-9. PMID: 25032261.
        View in: PubMed
      33. Morey R, Laurent L. Getting off the ground state: X chromosome inactivation knocks down barriers to differentiation. Cell Stem Cell. 2014 Feb 06; 14(2):131-2. PMID: 24506876; PMCID: PMC3984128.
        View in: PubMed, PubMed Central
      34. Thiagarajan RD, Morey R, Laurent L. The epigenome in pluripotency and differentiation. Epigenomics. 2014 Feb; 6(1):121-37. PMID: 24579950.
        View in: PubMed
      35. Ben-Yosef D, Boscolo FS, Amir H, Malcov M, Amit A, Laurent L. Genomic analysis of hESC pedigrees identifies de novo mutations and enables determination of the timing and origin of mutational events. Cell Rep. 2013 Sep 26; 4(6):1288-302. PMID: 24035391; PMCID: PMC3894204.
        View in: PubMed, PubMed Central
      36. Li Y, Moretto-Zita M, Soncin F, Wakeland A, Wolfe L, Leon-Garcia S, Pandian R, Pizzo D, Cui L, Nazor K, Loring JF, Crum CP, Laurent L, Parast MM. BMP4-directed trophoblast differentiation of human embryonic stem cells is mediated through a ?Np63+ cytotrophoblast stem cell state. Development. 2013 Oct; 140(19):3965-76. PMID: 24004950; PMCID: PMC3775414.
        View in: PubMed, PubMed Central
      37. Liao X, Xue H, Wang YC, Nazor KL, Guo S, Trivedi N, Peterson SE, Liu Y, Loring JF, Laurent L. Matched miRNA and mRNA signatures from an hESC-based in vitro model of pancreatic differentiation reveal novel regulatory interactions. J Cell Sci. 2013 Sep 01; 126(Pt 17):3848-61. PMID: 23813959; PMCID: PMC3757328.
        View in: PubMed, PubMed Central
      38. Jones JC, Sabatini K, Liao X, Tran HT, Lynch CL, Morey RE, Glenn-Pratola V, Boscolo FS, Yang Q, Parast MM, Liu Y, Peterson SE, Laurent L, Loring JF, Wang YC. Melanocytes derived from transgene-free human induced pluripotent stem cells. J Invest Dermatol. 2013 Aug; 133(8):2104-8. PMID: 23514962; PMCID: PMC3714355.
        View in: PubMed, PubMed Central
      39. Song HW, Anderson RA, Bayne RA, Gromoll J, Shimasaki S, Chang RJ, Parast MM, Laurent L, de Rooij DG, Hsieh TC, Wilkinson MF. The RHOX homeobox gene cluster is selectively expressed in human oocytes and male germ cells. Hum Reprod. 2013 Jun; 28(6):1635-46. PMID: 23482336; PMCID: PMC3657123.
        View in: PubMed, PubMed Central
      40. Gonzalez R, Garitaonandia I, Abramihina T, Wambua GK, Ostrowska A, Brock M, Noskov A, Boscolo FS, Craw JS, Laurent L, Snyder EY, Semechkin RA. Deriving dopaminergic neurons for clinical use. A practical approach. Sci Rep. 2013; 3:1463. PMID: 23492920; PMCID: PMC3597995.
        View in: PubMed, PubMed Central
      41. Kurian L, Sancho-Martinez I, Nivet E, Aguirre A, Moon K, Pendaries C, Volle-Challier C, Bono F, Herbert JM, Pulecio J, Xia Y, Li M, Montserrat N, Ruiz S, Dubova I, Rodriguez C, Denli AM, Boscolo FS, Thiagarajan RD, Gage FH, Loring JF, Laurent L, Izpisua Belmonte JC. Conversion of human fibroblasts to angioblast-like progenitor cells. Nat Methods. 2013 Jan; 10(1):77-83. PMID: 23202434; PMCID: PMC3531579.
        View in: PubMed, PubMed Central
      42. Ackerman WE, Carter AM, De Mestre AM, Golos TG, Jeschke U, Kusakabe K, Laurent L, Parast MM, Roberts RM, Robinson JM, Rutherford J, Soma H, Takizawa T, Ui-Tei K, Lash GE. IFPA Meeting 2012 Workshop Report I: comparative placentation and animal models, advanced techniques in placental histopathology, human pluripotent stem cells as a model for trophoblast differentiation. Placenta. 2013 Mar; 34 Suppl:S3-5. PMID: 23206905.
        View in: PubMed
      43. Leonardo TR, Schultheisz HL, Loring JF, Laurent L. The functions of microRNAs in pluripotency and reprogramming. Nat Cell Biol. 2012 Nov; 14(11):1114-21. PMID: 23131918.
        View in: PubMed
      44. Nazor KL, Loring JF, Laurent L. Equally potent? Does cellular reprogramming justify the abandonment of human embryonic stem cells? EMBO Rep. 2012 Oct; 13(10):890-4. PMID: 22986548; PMCID: PMC3463969.
        View in: PubMed, PubMed Central
      45. Ramsköld D, Luo S, Wang YC, Li R, Deng Q, Faridani OR, Daniels GA, Khrebtukova I, Loring JF, Laurent L, Schroth GP, Sandberg R. Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells. Nat Biotechnol. 2012 Aug; 30(8):777-82. PMID: 22820318; PMCID: PMC3467340.
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      46. Norton ME, Brar H, Weiss J, Karimi A, Laurent L, Caughey AB, Rodriguez MH, Williams J, Mitchell ME, Adair CD, Lee H, Jacobsson B, Tomlinson MW, Oepkes D, Hollemon D, Sparks AB, Oliphant A, Song K. Non-Invasive Chromosomal Evaluation (NICE) Study: results of a multicenter prospective cohort study for detection of fetal trisomy 21 and trisomy 18. Am J Obstet Gynecol. 2012 Aug; 207(2):137.e1-8. PMID: 22742782.
        View in: PubMed
      47. Nazor KL, Altun G, Lynch C, Tran H, Harness JV, Slavin I, Garitaonandia I, Müller FJ, Wang YC, Boscolo FS, Fakunle E, Dumevska B, Lee S, Park HS, Olee T, D'Lima DD, Semechkin R, Parast MM, Galat V, Laslett AL, Schmidt U, Keirstead HS, Loring JF, Laurent L. Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives. Cell Stem Cell. 2012 May 04; 10(5):620-34. PMID: 22560082; PMCID: PMC3348513.
        View in: PubMed, PubMed Central
      48. Liao WX, Laurent L, Agent S, Hodges J, Chen DB. Human placental expression of SLIT/ROBO signaling cues: effects of preeclampsia and hypoxia. Biol Reprod. 2012 Apr; 86(4):111. PMID: 22262697; PMCID: PMC3338657.
        View in: PubMed, PubMed Central
      49. Wang W, Feng L, Zhang H, Hachy S, Satohisa S, Laurent L, Parast M, Zheng J, Chen DB. Preeclampsia up-regulates angiogenesis-associated microRNA (i.e., miR-17, -20a, and -20b) that target ephrin-B2 and EPHB4 in human placenta. J Clin Endocrinol Metab. 2012 Jun; 97(6):E1051-9. PMID: 22438230; PMCID: PMC3387422.
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      50. Fan JB, Chen J, April CS, Fisher JS, Klotzle B, Bibikova M, Kaper F, Ronaghi M, Linnarsson S, Ota T, Chien J, Laurent L, Loring JF, Nisperos SV, Chen GY, Zhong JF. Highly parallel genome-wide expression analysis of single mammalian cells. PLoS One. 2012; 7(2):e30794. PMID: 22347404; PMCID: PMC3275609.
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      51. Peterson SE, Tran HT, Garitaonandia I, Han S, Nickey KS, Leonardo T, Laurent L, Loring JF. Teratoma generation in the testis capsule. J Vis Exp. 2011 Nov 07; (57):e3177. PMID: 22158256; PMCID: PMC3308584.
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      52. Wang YC, Nakagawa M, Garitaonandia I, Slavin I, Altun G, Lacharite RM, Nazor KL, Tran HT, Lynch CL, Leonardo TR, Liu Y, Peterson SE, Laurent L, Yamanaka S, Loring JF. Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis. Cell Res. 2011 Nov; 21(11):1551-63. PMID: 21894191; PMCID: PMC3364725.
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      53. Ben-Nun IF, Montague SC, Houck ML, Tran HT, Garitaonandia I, Leonardo TR, Wang YC, Charter SJ, Laurent L, Ryder OA, Loring JF. Induced pluripotent stem cells from highly endangered species. Nat Methods. 2011 Sep 04; 8(10):829-31. PMID: 21892153.
        View in: PubMed
      54. Golob JL, Kumar RM, Guenther MG, Pabon LM, Pratt GA, Loring JF, Laurent L, Young RA, Murry CE. Evidence that gene activation and silencing during stem cell differentiation requires a transcriptionally paused intermediate state. PLoS One. 2011; 6(8):e22416. PMID: 21886766; PMCID: PMC3158746.
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      55. Peterson SE, Westra JW, Rehen SK, Young H, Bushman DM, Paczkowski CM, Yung YC, Lynch CL, Tran HT, Nickey KS, Wang YC, Laurent L, Loring JF, Carpenter MK, Chun J. Normal human pluripotent stem cell lines exhibit pervasive mosaic aneuploidy. PLoS One. 2011; 6(8):e23018. PMID: 21857983; PMCID: PMC3156708.
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      56. Macarthur CC, Xue H, Van Hoof D, Lieu PT, Dudas M, Fontes A, Swistowski A, Touboul T, Seerke R, Laurent L, Loring JF, German MS, Zeng X, Rao MS, Lakshmipathy U, Chesnut JD, Liu Y. Chromatin insulator elements block transgene silencing in engineered human embryonic stem cell lines at a defined chromosome 13 locus. Stem Cells Dev. 2012 Jan 20; 21(2):191-205. PMID: 21699412; PMCID: PMC3258440.
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      57. Ruff D, MacArthur C, Tran H, Bergseid J, Tian J, Shannon M, Chen SM, Fontes A, Laurent L, Swartzman E, Taliana A, Rao M, Lieu PT. Applications of quantitative polymerase chain reaction protein assays during reprogramming. Stem Cells Dev. 2012 Mar 01; 21(4):530-8. PMID: 21476854.
        View in: PubMed
      58. Liu GH, Suzuki K, Qu J, Sancho-Martinez I, Yi F, Li M, Kumar S, Nivet E, Kim J, Soligalla RD, Dubova I, Goebl A, Plongthongkum N, Fung HL, Zhang K, Loring JF, Laurent L, Izpisua Belmonte JC. Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs. Cell Stem Cell. 2011 Jun 03; 8(6):688-94. PMID: 21596650; PMCID: PMC3480729.
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      59. Müller FJ, Schuldt BM, Williams R, Mason D, Altun G, Papapetrou EP, Danner S, Goldmann JE, Herbst A, Schmidt NO, Aldenhoff JB, Laurent L, Loring JF. A bioinformatic assay for pluripotency in human cells. Nat Methods. 2011 Apr; 8(4):315-7. PMID: 21378979; PMCID: PMC3265323.
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      60. Laurent L, Ulitsky I, Slavin I, Tran H, Schork A, Morey R, Lynch C, Harness JV, Lee S, Barrero MJ, Ku S, Martynova M, Semechkin R, Galat V, Gottesfeld J, Izpisua Belmonte JC, Murry C, Keirstead HS, Park HS, Schmidt U, Laslett AL, Muller FJ, Nievergelt CM, Shamir R, Loring JF. Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell Stem Cell. 2011 Jan 07; 8(1):106-18. PMID: 21211785; PMCID: PMC3043464.
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      61. Harness JV, Turovets NA, Seiler MJ, Nistor G, Altun G, Agapova LS, Ferguson D, Laurent L, Loring JF, Keirstead HS. Equivalence of conventionally-derived and parthenote-derived human embryonic stem cells. PLoS One. 2011 Jan 07; 6(1):e14499. PMID: 21249129; PMCID: PMC3017547.
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      62. Ku S, Soragni E, Campau E, Thomas EA, Altun G, Laurent L, Loring JF, Napierala M, Gottesfeld JM. Friedreich's ataxia induced pluripotent stem cells model intergenerational GAA·TTC triplet repeat instability. Cell Stem Cell. 2010 Nov 05; 7(5):631-7. PMID: 21040903; PMCID: PMC2987635.
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      63. Ulitsky I, Laurent L, Shamir R. Towards computational prediction of microRNA function and activity. Nucleic Acids Res. 2010 Aug; 38(15):e160. PMID: 20576699; PMCID: PMC2926627.
        View in: PubMed, PubMed Central
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