Arwa Kurabi

Title(s)Associate Project Scientist, Surgery
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
Emailakurabi@ucsd.edu
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    Collapse Research 
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    Establishment of an animal model of human-specific responses to middle ear infection.
    NIH R03DC014801Apr 5, 2016 - Mar 31, 2020
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hearing rehabilitation and microbial shift after middle ear surgery with Vibrant Soundbridge in patients with chronic otitis media. Eur Arch Otorhinolaryngol. 2023 Jul; 280(7):3107-3118. Bruchhage KL, Lupatsii M, Möllenkolk F, Leffers D, Kurabi A, Jürgens T, Graspeuntner S, Hollfelder D, Leichtle A. PMID: 36662266; PMCID: PMC10220096.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Resolution of otitis media in a humanized mouse model. Front Genet. 2022; 13:958540. Son YL, Pak K, Muradagha N, Heo KW, Leichtle A, Kurabi A. PMID: 36437913; PMCID: PMC9682244.
      View in: PubMed   Mentions:
    3. The ECRG4 cleavage product augurin binds the endotoxin receptor and influences the innate immune response during otitis media. Front Genet. 2022; 13:932555. Kurabi A, Hur DG, Pak K, Gibson M, Webster NJG, Baird A, Eliceiri BP, Ryan AF. PMID: 36092940; PMCID: PMC9461705.
      View in: PubMed   Mentions:
    4. Essential Role of the Innate Immune Adaptor RIP2 in the Response to Otitis Media. Front Genet. 2022; 13:893085. Kurabi A, Lee J, Pak K, Leichtle A, Ryan AF. PMID: 35903351; PMCID: PMC9315102.
      View in: PubMed   Mentions:
    5. Immunomodulation as a Protective Strategy in Chronic Otitis Media. Front Cell Infect Microbiol. 2022; 12:826192. Leichtle A, Kurabi A, Leffers D, Därr M, Draf CS, Ryan AF, Bruchhage KL. PMID: 35433505; PMCID: PMC9005906.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    6. HB-EGF Plays a Pivotal Role in Mucosal Hyperplasia During Otitis Media Induced by a Viral Analog. Front Cell Infect Microbiol. 2022; 12:823714. Sakamoto T, Pak K, Chavez E, Ryan AF, Kurabi A. PMID: 35281434; PMCID: PMC8904902.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. A transcytotic transport mechanism across the tympanic membrane. Sci Rep. 2022 01 19; 12(1):984. Kurabi A, Pak K, Chavez E, Doan J, Ryan AF. PMID: 35046419; PMCID: PMC8770641.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. Leukotriene B4 Is a Major Determinant of Leukocyte Recruitment During Otitis Media. Front Cell Infect Microbiol. 2021; 11:768815. Heo KW, Pak K, Kurabi A, Ryan AF. PMID: 35004347; PMCID: PMC8727869.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    9. A Screen of Autophagy Compounds Implicates the Proteasome in Mammalian Aminoglycoside-Induced Hair Cell Damage. Front Cell Dev Biol. 2021; 9:762751. Draf C, Wyrick T, Chavez E, Pak K, Kurabi A, Leichtle A, Dazert S, Ryan AF. PMID: 34765606; PMCID: PMC8576371.
      View in: PubMed   Mentions: 2  
    10. Immunohistochemical and qPCR Detection of SARS-CoV-2 in the Human Middle Ear Versus the Nasal Cavity: Case Series. Head Neck Pathol. 2022 Jun; 16(2):607-611. Kurabi A, Pak K, DeConde AS, Ryan AF, Yan CH. PMID: 34455569; PMCID: PMC8401349.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    11. [Immunomodulation in Cholesteatoma]. Laryngorhinootologie. 2022 Apr; 101(4):310-319. Leichtle A, Leffers D, Daerr MG, Draf C, Kurabi A, Ryan AF, Rupp J, Bruchhage KL. PMID: 34233375.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    12. Macrophage Depletion in CCR2-/- Mice Delays Bacterial Clearance and Enhances Neutrophil Infiltration in an Acute Otitis Media Model. J Infect Dis. 2021 02 03; 223(2):333-341. Hur DG, Kurabi A, Lim HW, Spriggs M, Pak K, Ryan AF. PMID: 32572481; PMCID: PMC7857354.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    13. Molecular Screening Strategy to Identify a Non-invasive Delivery Mechanism for the Treatment of Middle Ear Disorders. Front Med (Lausanne). 2020; 7:503819. Kurabi A, Cooper M, Spriggs M, Xu Y, Schaerer D, Ryan AF. PMID: 33392211; PMCID: PMC7775502.
      View in: PubMed   Mentions:
    14. A kinase inhibitor screen identifies signaling pathways regulating mucosal growth during otitis media. PLoS One. 2020; 15(8):e0235634. Noel J, Suzukawa K, Chavez E, Pak K, Wasserman SI, Kurabi A, Ryan AF. PMID: 32760078; PMCID: PMC7410257.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    15. Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection. Front Genet. 2020; 11:358. Ryan AF, Nasamran CA, Pak K, Draf C, Fisch KM, Webster N, Kurabi A. PMID: 32351546; PMCID: PMC7174727.
      View in: PubMed   Mentions: 15  
    16. Panel 2- recent advance in otitis media bioinformatics. Int J Pediatr Otorhinolaryngol. 2020 Mar; 130 Suppl 1:109834. Preciado D, Li JD, Komatsu K, Kurabi A, Nino G, Val S, Vijayasekaran S, Ziv O, Hermansson A. PMID: 31899006; PMCID: PMC7184535.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Panel 8: Vaccines and immunology. Int J Pediatr Otorhinolaryngol. 2020 Mar; 130 Suppl 1:109839. Alderson MR, Murphy T, Pelton SI, Novotny LA, Hammitt LL, Kurabi A, Li JD, Thornton RB, Kirkham LS. PMID: 31948716; PMCID: PMC7153269.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    18. Role of the PI3K/AKT pathway and PTEN in otitis media. Exp Cell Res. 2020 02 01; 387(1):111758. Lee HH, Chin A, Pak K, Wasserman SI, Kurabi A, Ryan AF. PMID: 31837294; PMCID: PMC7824983.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    19. Inflammation associated with noise-induced hearing loss. J Acoust Soc Am. 2019 11; 146(5):4020. Frye MD, Ryan AF, Kurabi A. PMID: 31795714; PMCID: PMC7480080.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    20. NOD1/NOD2-mediated recognition of non-typeable Haemophilus influenzae activates innate immunity during otitis media. Innate Immun. 2019 11; 25(8):503-512. Lee J, Leichtle A, Zuckerman E, Pak K, Spriggs M, Wasserman SI, Kurabi A. PMID: 31474163; PMCID: PMC6900663.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    21. Lack of the hyaluronan receptor CD44 affects the course of bacterial otitis media and reduces leukocyte recruitment to the middle ear. BMC Immunol. 2019 06 21; 20(1):20. Lim HW, Pak K, Kurabi A, Ryan AF. PMID: 31226944; PMCID: PMC6588864.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    22. Active Transport of Peptides Across the Intact Human Tympanic Membrane. Sci Rep. 2018 08 07; 8(1):11815. Kurabi A, Schaerer D, Noack V, Bernhardt M, Pak K, Alexander T, Husseman J, Nguyen Q, Harris JP, Ryan AF. PMID: 30087425; PMCID: PMC6081404.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    23. Screening Mammalian Cochlear Hair Cells to Identify Critical Processes in Aminoglycoside-Mediated Damage. Front Cell Neurosci. 2018; 12:179. Lim HW, Pak K, Ryan AF, Kurabi A. PMID: 30013464; PMCID: PMC6036173.
      View in: PubMed   Mentions: 2  
    24. Screening antioxidants for the protection of cochlear sensory cells. Neural Regen Res. 2018 Jan; 13(1):62-64. Hur DG, Kurabi A, Ryan AF. PMID: 29451206; PMCID: PMC5840991.
      View in: PubMed   Mentions: 3  
    25. A kinase inhibitor library screen identifies novel enzymes involved in ototoxic damage to the murine organ of Corti. PLoS One. 2017; 12(10):e0186001. Ryals M, Pak K, Jalota R, Kurabi A, Ryan AF. PMID: 29049311; PMCID: PMC5648133.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    26. Otitis Media and Nasopharyngeal Colonization in ccl3-/- Mice. Infect Immun. 2017 11; 85(11). Deniffel D, Nuyen B, Pak K, Suzukawa K, Hung J, Kurabi A, Wasserman SI, Ryan AF. PMID: 28847849; PMCID: PMC5649018.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    27. An Antioxidant Screen Identifies Candidates for Protection of Cochlear Hair Cells from Gentamicin Toxicity. Front Cell Neurosci. 2017; 11:242. Noack V, Pak K, Jalota R, Kurabi A, Ryan AF. PMID: 28867994; PMCID: PMC5563352.
      View in: PubMed   Mentions: 18  
    28. Optimisation of peptides that actively cross the tympanic membrane by random amino acid extension: a phage display study. J Drug Target. 2018 02; 26(2):127-134. Kurabi A, Schaerer D, Chang L, Pak K, Ryan AF. PMID: 28658990; PMCID: PMC6223256.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    29. Panel 8: Report on Recent Advances in Molecular and Cellular Biochemistry. Otolaryngol Head Neck Surg. 2017 04; 156(4_suppl):S106-S113. Preciado D, Granath A, Lin J, Val S, Kurabi A, Johnston N, Vijayasekaran S, Valdez T, Depireux D, Hermansson A. PMID: 28372528.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    30. Panel 5: Immunology. Otolaryngol Head Neck Surg. 2017 04; 156(4_suppl):S63-S75. Kyd JM, Hotomi M, Kono M, Kurabi A, Pichichero M, Ryan A, Swords WE, Thornton R. PMID: 28372530.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    31. Peptides actively transported across the tympanic membrane: Functional and structural properties. PLoS One. 2017; 12(2):e0172158. Kurabi A, Beasley KA, Chang L, McCann J, Pak K, Ryan AF. PMID: 28234923; PMCID: PMC5325213.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    32. Cellular mechanisms of noise-induced hearing loss. Hear Res. 2017 06; 349:129-137. Kurabi A, Keithley EM, Housley GD, Ryan AF, Wong AC. PMID: 27916698; PMCID: PMC6750278.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    33. Both canonical and non-canonical NF-κB activation contribute to the proliferative response of the middle ear mucosa during bacterial infection. Innate Immun. 2016 11; 22(8):626-634. Cho CG, Pak K, Webster N, Kurabi A, Ryan AF. PMID: 27655045; PMCID: PMC5333768.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    34. Discovery of a Biological Mechanism of Active Transport through the Tympanic Membrane to the Middle Ear. Sci Rep. 2016 Mar 07; 6:22663. Kurabi A, Pak KK, Bernhardt M, Baird A, Ryan AF. PMID: 26946957; PMCID: PMC4780071.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    35. Innate Immunity: Orchestrating Inflammation and Resolution of Otitis Media. Curr Allergy Asthma Rep. 2016 Jan; 16(1):6. Kurabi A, Pak K, Ryan AF, Wasserman SI. PMID: 26732809; PMCID: PMC6752202.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    36. Esophageal cancer-related gene-4 (ECRG4) interactions with the innate immunity receptor complex. Inflamm Res. 2015 Feb; 64(2):107-18. Podvin S, Dang X, Meads M, Kurabi A, Costantini T, Eliceiri BP, Baird A, Coimbra R. PMID: 25511108; PMCID: PMC4301958.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    37. A mouse model of otitis media identifies HB-EGF as a mediator of inflammation-induced mucosal proliferation. PLoS One. 2014; 9(7):e102739. Suzukawa K, Tomlin J, Pak K, Chavez E, Kurabi A, Baird A, Wasserman SI, Ryan AF. PMID: 25033458; PMCID: PMC4102546.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    38. The inflammasome adaptor ASC contributes to multiple innate immune processes in the resolution of otitis media. Innate Immun. 2015 Feb; 21(2):203-14. Kurabi A, Lee J, Wong C, Pak K, Hoffman HM, Ryan AF, Wasserman SI. PMID: 24652041; PMCID: PMC4379507.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    39. Esophageal cancer-related gene 4 at the interface of injury, inflammation, infection, and malignancy. Gastrointest Cancer. 2014; 2014(4):131-142. Baird A, Lee J, Podvin S, Kurabi A, Dang X, Coimbra R, Costantini T, Bansal V, Eliceiri BP. PMID: 25580077; PMCID: PMC4287990.
      View in: PubMed   Mentions: 16  
    40. Solution structure and peptide binding of the PTB domain from the AIDA1 postsynaptic signaling scaffolding protein. PLoS One. 2013; 8(6):e65605. Smirnova E, Shanbhag R, Kurabi A, Mobli M, Kwan JJ, Donaldson LW. PMID: 23799029; PMCID: PMC3683042.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    41. Ecrg4 attenuates the inflammatory proliferative response of mucosal epithelial cells to infection. PLoS One. 2013; 8(4):e61394. Kurabi A, Pak K, Dang X, Coimbra R, Eliceiri BP, Ryan AF, Baird A. PMID: 23626679; PMCID: PMC3634077.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    42. Esophageal cancer related gene-4 is a choroid plexus-derived injury response gene: evidence for a biphasic response in early and late brain injury. PLoS One. 2011; 6(9):e24609. Podvin S, Gonzalez AM, Miller MC, Dang X, Botfield H, Donahue JE, Kurabi A, Boissaud-Cooke M, Rossi R, Leadbeater WE, Johanson CE, Coimbra R, Stopa EG, Eliceiri BP, Baird A. PMID: 21935431; PMCID: PMC3173480.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    43. Solution structure of the carboxy-terminal Tudor domain from human Coilin. FEBS Lett. 2010 Oct 22; 584(20):4351-6. Shanbhag R, Kurabi A, Kwan JJ, Donaldson LW. PMID: 20875822.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    44. A nuclear localization signal at the SAM-SAM domain interface of AIDA-1 suggests a requirement for domain uncoupling prior to nuclear import. J Mol Biol. 2009 Oct 09; 392(5):1168-77. Kurabi A, Brener S, Mobli M, Kwan JJ, Donaldson LW. PMID: 19666031.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    45. Immobilization of beta-glucosidase on Eupergit C for lignocellulose hydrolysis. Biotechnol Lett. 2006 Feb; 28(3):151-6. Tu M, Zhang X, Kurabi A, Gilkes N, Mabee W, Saddler J. PMID: 16489491.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    46. Weak lignin-binding enzymes: a novel approach to improve activity of cellulases for hydrolysis of lignocellulosics. Appl Biochem Biotechnol. 2005; 121-124:163-70. Berlin A, Gilkes N, Kurabi A, Bura R, Tu M, Kilburn D, Saddler J. PMID: 15917596.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    47. Enzymatic hydrolysis of steam-exploded and ethanol organosolv-pretreated Douglas-Firby novel and commercial fungal cellulases. Appl Biochem Biotechnol. 2005; 121-124:219-30. Kurabi A, Berlin A, Gilkes N, Kilburn D, Bura R, Robinson J, Markov A, Skomarovsky A, Gusakov A, Okunev O, Sinitsyn A, Gregg D, Xie D, Saddler J. PMID: 15917601.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCellsPHPublic Health
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