Arwa Kurabi

Title(s)	Associate Project Scientist, Otolaryngology
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

research activities and funding

Establishment of an animal model of human-specific responses to middle ear infection.
NIH R03DC014801Apr 5, 2016 - Mar 31, 2020
Role: Principal Investigator

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Peptides rapidly transport antibiotic across the intact tympanic membrane to treat a middle ear infection. Drug Deliv. 2025 Dec; 32(1):2463427. Kurabi A, Sereno E, Ryan AF. PMID: 39960246; PMCID: PMC11834822.

View in: PubMed Mentions: Fields:
Dru Drug Therapy Pha Pharmacology
Translation:Animals Cells
Peptide-Mediated Transport Across the Intact Tympanic Membrane Is Intracellular, with the Rate Determined by the Middle Ear Mucosal Epithelium. Biomolecules. 2024 Dec 19; 14(12). Kurabi A, Xu Y, Chavez E, Khieu V, Ryan AF. PMID: 39766339; PMCID: PMC11727143.

View in: PubMed Mentions: Fields:
Bio Biochemistry Mol Molecular Biology
Translation:Humans Animals Cells
Combinatorial protection of cochlear hair cells: not too little but not too much. Front Cell Neurosci. 2024; 18:1458720. Kurabi A, Pak K, Lee EJ, Ryan AF. PMID: 39355176; PMCID: PMC11442228.

View in: PubMed Mentions:
Anti-inflammatory response to 1,8-Cineol and associated microbial communities in Otitis media patients. Sci Rep. 2024 07 16; 14(1):16362. Leichtle A, Lupatsii M, Graspeuntner S, Jeschke S, Penxová Z, Kurabi A, Ryan AF, Rupp J, Pries R, Bruchhage KL. PMID: 39014066; PMCID: PMC11252366.

View in: PubMed Mentions: 3 Fields:
Sci Science
Translation:Humans Cells
Immunomodulatory Response of the Middle Ear Epithelial Cells in Otitis Media. Otol Neurotol. 2024 Mar 01; 45(3):e248-e255. Leffers D, Penxova Z, Kempin T, Därr M, Fleckner J, Hollfelder D, Ryan AF, Bruchhage KL, Kurabi A, Leichtle A. PMID: 38238924; PMCID: PMC10922874.

View in: PubMed Mentions: 1 Fields:
Neu Neurology Oto Otolaryngology
Translation:Humans Animals Cells
PANEL 3: Otitis media animal models, cell culture, tissue regeneration & pathophysiology. Int J Pediatr Otorhinolaryngol. 2024 Jan; 176:111814. Kurabi A, Dewan K, Kerschner JE, Leichtle A, Li JD, Santa Maria PL, Preciado D. PMID: 38101097.

View in: PubMed Mentions: Fields:
Oto Otolaryngology Ped Pediatrics
Translation:Humans Animals
Hearing rehabilitation and microbial shift after middle ear surgery with Vibrant Soundbridge in patients with chronic otitis media. Eur Arch Otorhinolaryngol. 2023 Jul; 280(7):3107-3118. Bruchhage KL, Lupatsii M, Möllenkolk F, Leffers D, Kurabi A, Jürgens T, Graspeuntner S, Hollfelder D, Leichtle A. PMID: 36662266; PMCID: PMC10220096.

View in: PubMed Mentions: 4 Fields:
Oto Otolaryngology
Translation:Humans
Resolution of otitis media in a humanized mouse model. Front Genet. 2022; 13:958540. Son YL, Pak K, Muradagha N, Heo KW, Leichtle A, Kurabi A. PMID: 36437913; PMCID: PMC9682244.

View in: PubMed Mentions: 2
The ECRG4 cleavage product augurin binds the endotoxin receptor and influences the innate immune response during otitis media. Front Genet. 2022; 13:932555. Kurabi A, Hur DG, Pak K, Gibson M, Webster NJG, Baird A, Eliceiri BP, Ryan AF. PMID: 36092940; PMCID: PMC9461705.

View in: PubMed Mentions:
Essential Role of the Innate Immune Adaptor RIP2 in the Response to Otitis Media. Front Genet. 2022; 13:893085. Kurabi A, Lee J, Pak K, Leichtle A, Ryan AF. PMID: 35903351; PMCID: PMC9315102.

View in: PubMed Mentions: 2
Immunomodulation as a Protective Strategy in Chronic Otitis Media. Front Cell Infect Microbiol. 2022; 12:826192. Leichtle A, Kurabi A, Leffers D, Därr M, Draf CS, Ryan AF, Bruchhage KL. PMID: 35433505; PMCID: PMC9005906.

View in: PubMed Mentions: 4 Fields:
Cel Cell Biology Com Communicable Diseases Mic Microbiology
Translation:Humans Animals
HB-EGF Plays a Pivotal Role in Mucosal Hyperplasia During Otitis Media Induced by a Viral Analog. Front Cell Infect Microbiol. 2022; 12:823714. Sakamoto T, Pak K, Chavez E, Ryan AF, Kurabi A. PMID: 35281434; PMCID: PMC8904902.

View in: PubMed Mentions: 2 Fields:
Cel Cell Biology Com Communicable Diseases Mic Microbiology
Translation:Humans Animals Cells
A transcytotic transport mechanism across the tympanic membrane. Sci Rep. 2022 01 19; 12(1):984. Kurabi A, Pak K, Chavez E, Doan J, Ryan AF. PMID: 35046419; PMCID: PMC8770641.

View in: PubMed Mentions: 4 Fields:
Sci Science
Translation:Animals Cells
Leukotriene B4 Is a Major Determinant of Leukocyte Recruitment During Otitis Media. Front Cell Infect Microbiol. 2021; 11:768815. Heo KW, Pak K, Kurabi A, Ryan AF. PMID: 35004347; PMCID: PMC8727869.

View in: PubMed Mentions: 1 Fields:
Cel Cell Biology Com Communicable Diseases Mic Microbiology
Translation:Animals Cells
A Screen of Autophagy Compounds Implicates the Proteasome in Mammalian Aminoglycoside-Induced Hair Cell Damage. Front Cell Dev Biol. 2021; 9:762751. Draf C, Wyrick T, Chavez E, Pak K, Kurabi A, Leichtle A, Dazert S, Ryan AF. PMID: 34765606; PMCID: PMC8576371.

View in: PubMed Mentions: 5
Immunohistochemical and qPCR Detection of SARS-CoV-2 in the Human Middle Ear Versus the Nasal Cavity: Case Series. Head Neck Pathol. 2022 Jun; 16(2):607-611. Kurabi A, Pak K, DeConde AS, Ryan AF, Yan CH. PMID: 34455569; PMCID: PMC8401349.

View in: PubMed Mentions: 6 Fields:
Neo Neoplasms Pat Pathology
Translation:Humans Cells
[Immunomodulation in Cholesteatoma]. Laryngorhinootologie. 2022 Apr; 101(4):310-319. Leichtle A, Leffers D, Daerr MG, Draf C, Kurabi A, Ryan AF, Rupp J, Bruchhage KL. PMID: 34233375.

View in: PubMed Mentions: 3 Fields:
Oto Otolaryngology
Translation:Humans Animals
Macrophage Depletion in CCR2-/- Mice Delays Bacterial Clearance and Enhances Neutrophil Infiltration in an Acute Otitis Media Model. J Infect Dis. 2021 02 03; 223(2):333-341. Hur DG, Kurabi A, Lim HW, Spriggs M, Pak K, Ryan AF. PMID: 32572481; PMCID: PMC7857354.

View in: PubMed Mentions: 4 Fields:
Com Communicable Diseases
Translation:Animals Cells
Molecular Screening Strategy to Identify a Non-invasive Delivery Mechanism for the Treatment of Middle Ear Disorders. Front Med (Lausanne). 2020; 7:503819. Kurabi A, Cooper M, Spriggs M, Xu Y, Schaerer D, Ryan AF. PMID: 33392211; PMCID: PMC7775502.

View in: PubMed Mentions:
A kinase inhibitor screen identifies signaling pathways regulating mucosal growth during otitis media. PLoS One. 2020; 15(8):e0235634. Noel J, Suzukawa K, Chavez E, Pak K, Wasserman SI, Kurabi A, Ryan AF. PMID: 32760078; PMCID: PMC7410257.

View in: PubMed Mentions: Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals Cells
Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection. Front Genet. 2020; 11:358. Ryan AF, Nasamran CA, Pak K, Draf C, Fisch KM, Webster N, Kurabi A. PMID: 32351546; PMCID: PMC7174727.

View in: PubMed Mentions: 17
Panel 2- recent advance in otitis media bioinformatics. Int J Pediatr Otorhinolaryngol. 2020 Mar; 130 Suppl 1:109834. Preciado D, Li JD, Komatsu K, Kurabi A, Nino G, Val S, Vijayasekaran S, Ziv O, Hermansson A. PMID: 31899006; PMCID: PMC7184535.

View in: PubMed Mentions: Fields:
Oto Otolaryngology Ped Pediatrics
Translation:Humans
Panel 8: Vaccines and immunology. Int J Pediatr Otorhinolaryngol. 2020 Mar; 130 Suppl 1:109839. Alderson MR, Murphy T, Pelton SI, Novotny LA, Hammitt LL, Kurabi A, Li JD, Thornton RB, Kirkham LS. PMID: 31948716; PMCID: PMC7153269.

View in: PubMed Mentions: 4 Fields:
Oto Otolaryngology Ped Pediatrics
Translation:Humans PHPublic Health
Role of the PI3K/AKT pathway and PTEN in otitis media. Exp Cell Res. 2020 02 01; 387(1):111758. Lee HH, Chin A, Pak K, Wasserman SI, Kurabi A, Ryan AF. PMID: 31837294; PMCID: PMC7824983.

View in: PubMed Mentions: 2 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Inflammation associated with noise-induced hearing loss. J Acoust Soc Am. 2019 11; 146(5):4020. Frye MD, Ryan AF, Kurabi A. PMID: 31795714; PMCID: PMC7480080.

View in: PubMed Mentions: 66 Fields:
Aud Audiology Spe Speech-Language Pathology
Translation:Humans Animals Cells
NOD1/NOD2-mediated recognition of non-typeable Haemophilus influenzae activates innate immunity during otitis media. Innate Immun. 2019 11; 25(8):503-512. Lee J, Leichtle A, Zuckerman E, Pak K, Spriggs M, Wasserman SI, Kurabi A. PMID: 31474163; PMCID: PMC6900663.

View in: PubMed Mentions: 9 Fields:
All Allergy and Immunology Bac Bacteriology
Translation:Humans Animals Cells
Lack of the hyaluronan receptor CD44 affects the course of bacterial otitis media and reduces leukocyte recruitment to the middle ear. BMC Immunol. 2019 06 21; 20(1):20. Lim HW, Pak K, Kurabi A, Ryan AF. PMID: 31226944; PMCID: PMC6588864.

View in: PubMed Mentions: 7 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
Active Transport of Peptides Across the Intact Human Tympanic Membrane. Sci Rep. 2018 08 07; 8(1):11815. Kurabi A, Schaerer D, Noack V, Bernhardt M, Pak K, Alexander T, Husseman J, Nguyen Q, Harris JP, Ryan AF. PMID: 30087425; PMCID: PMC6081404.

View in: PubMed Mentions: 11 Fields:
Sci Science
Translation:Humans Animals
Screening Mammalian Cochlear Hair Cells to Identify Critical Processes in Aminoglycoside-Mediated Damage. Front Cell Neurosci. 2018; 12:179. Lim HW, Pak K, Ryan AF, Kurabi A. PMID: 30013464; PMCID: PMC6036173.

View in: PubMed Mentions: 6
Screening antioxidants for the protection of cochlear sensory cells. Neural Regen Res. 2018 Jan; 13(1):62-64. Hur DG, Kurabi A, Ryan AF. PMID: 29451206; PMCID: PMC5840991.

View in: PubMed Mentions: 5
A kinase inhibitor library screen identifies novel enzymes involved in ototoxic damage to the murine organ of Corti. PLoS One. 2017; 12(10):e0186001. Ryals M, Pak K, Jalota R, Kurabi A, Ryan AF. PMID: 29049311; PMCID: PMC5648133.

View in: PubMed Mentions: 6 Fields:
Med Medicine (General)Sci Science
Translation:Animals
Otitis Media and Nasopharyngeal Colonization in ccl3-/- Mice. Infect Immun. 2017 11; 85(11). Deniffel D, Nuyen B, Pak K, Suzukawa K, Hung J, Kurabi A, Wasserman SI, Ryan AF. PMID: 28847849; PMCID: PMC5649018.

View in: PubMed Mentions: 10 Fields:
All Allergy and Immunology Com Communicable Diseases
Translation:Animals Cells
An Antioxidant Screen Identifies Candidates for Protection of Cochlear Hair Cells from Gentamicin Toxicity. Front Cell Neurosci. 2017; 11:242. Noack V, Pak K, Jalota R, Kurabi A, Ryan AF. PMID: 28867994; PMCID: PMC5563352.

View in: PubMed Mentions: 24
Optimisation of peptides that actively cross the tympanic membrane by random amino acid extension: a phage display study. J Drug Target. 2018 02; 26(2):127-134. Kurabi A, Schaerer D, Chang L, Pak K, Ryan AF. PMID: 28658990; PMCID: PMC6223256.

View in: PubMed Mentions: 7 Fields:
Pha Pharmacology
Translation:Animals Cells
Panel 8: Report on Recent Advances in Molecular and Cellular Biochemistry. Otolaryngol Head Neck Surg. 2017 04; 156(4_suppl):S106-S113. Preciado D, Granath A, Lin J, Val S, Kurabi A, Johnston N, Vijayasekaran S, Valdez T, Depireux D, Hermansson A. PMID: 28372528.

View in: PubMed Mentions: 2 Fields:
Gen General Surgery Oto Otolaryngology
Translation:Animals Cells
Panel 5: Immunology. Otolaryngol Head Neck Surg. 2017 04; 156(4_suppl):S63-S75. Kyd JM, Hotomi M, Kono M, Kurabi A, Pichichero M, Ryan A, Swords WE, Thornton R. PMID: 28372530.

View in: PubMed Mentions: 2 Fields:
Gen General Surgery Oto Otolaryngology
Translation:Humans
Peptides actively transported across the tympanic membrane: Functional and structural properties. PLoS One. 2017; 12(2):e0172158. Kurabi A, Beasley KA, Chang L, McCann J, Pak K, Ryan AF. PMID: 28234923; PMCID: PMC5325213.

View in: PubMed Mentions: 10 Fields:
Med Medicine (General)Sci Science
Translation:Animals Cells
Cellular mechanisms of noise-induced hearing loss. Hear Res. 2017 06; 349:129-137. Kurabi A, Keithley EM, Housley GD, Ryan AF, Wong AC. PMID: 27916698; PMCID: PMC6750278.

View in: PubMed Mentions: 152 Fields:
Aud Audiology
Translation:Humans Animals Cells PHPublic Health
Both canonical and non-canonical NF-κB activation contribute to the proliferative response of the middle ear mucosa during bacterial infection. Innate Immun. 2016 11; 22(8):626-634. Cho CG, Pak K, Webster N, Kurabi A, Ryan AF. PMID: 27655045; PMCID: PMC5333768.

View in: PubMed Mentions: 6 Fields:
All Allergy and Immunology Bac Bacteriology
Translation:Humans Animals Cells
Discovery of a Biological Mechanism of Active Transport through the Tympanic Membrane to the Middle Ear. Sci Rep. 2016 Mar 07; 6:22663. Kurabi A, Pak KK, Bernhardt M, Baird A, Ryan AF. PMID: 26946957; PMCID: PMC4780071.

View in: PubMed Mentions: 16 Fields:
Sci Science
Translation:Animals
Innate Immunity: Orchestrating Inflammation and Resolution of Otitis Media. Curr Allergy Asthma Rep. 2016 Jan; 16(1):6. Kurabi A, Pak K, Ryan AF, Wasserman SI. PMID: 26732809; PMCID: PMC6752202.

View in: PubMed Mentions: 22 Fields:
All Allergy and Immunology Pul Pulmonary Medicine
Translation:Humans
Esophageal cancer-related gene-4 (ECRG4) interactions with the innate immunity receptor complex. Inflamm Res. 2015 Feb; 64(2):107-18. Podvin S, Dang X, Meads M, Kurabi A, Costantini T, Eliceiri BP, Baird A, Coimbra R. PMID: 25511108; PMCID: PMC4301958.

View in: PubMed Mentions: 14 Fields:
All Allergy and Immunology Pat Pathology
Translation:Humans Cells
A mouse model of otitis media identifies HB-EGF as a mediator of inflammation-induced mucosal proliferation. PLoS One. 2014; 9(7):e102739. Suzukawa K, Tomlin J, Pak K, Chavez E, Kurabi A, Baird A, Wasserman SI, Ryan AF. PMID: 25033458; PMCID: PMC4102546.

View in: PubMed Mentions: 13 Fields:
Med Medicine (General)Sci Science
Translation:Animals
The inflammasome adaptor ASC contributes to multiple innate immune processes in the resolution of otitis media. Innate Immun. 2015 Feb; 21(2):203-14. Kurabi A, Lee J, Wong C, Pak K, Hoffman HM, Ryan AF, Wasserman SI. PMID: 24652041; PMCID: PMC4379507.

View in: PubMed Mentions: 15 Fields:
All Allergy and Immunology Bac Bacteriology
Translation:Humans Animals Cells
Esophageal cancer-related gene 4 at the interface of injury, inflammation, infection, and malignancy. Gastrointest Cancer. 2014; 2014(4):131-142. Baird A, Lee J, Podvin S, Kurabi A, Dang X, Coimbra R, Costantini T, Bansal V, Eliceiri BP. PMID: 25580077; PMCID: PMC4287990.

View in: PubMed Mentions: 17
Solution structure and peptide binding of the PTB domain from the AIDA1 postsynaptic signaling scaffolding protein. PLoS One. 2013; 8(6):e65605. Smirnova E, Shanbhag R, Kurabi A, Mobli M, Kwan JJ, Donaldson LW. PMID: 23799029; PMCID: PMC3683042.

View in: PubMed Mentions: 6 Fields:
Med Medicine (General)Sci Science
Translation:Humans Cells
Ecrg4 attenuates the inflammatory proliferative response of mucosal epithelial cells to infection. PLoS One. 2013; 8(4):e61394. Kurabi A, Pak K, Dang X, Coimbra R, Eliceiri BP, Ryan AF, Baird A. PMID: 23626679; PMCID: PMC3634077.

View in: PubMed Mentions: 26 Fields:
Med Medicine (General)Sci Science
Translation:Animals Cells
Esophageal cancer related gene-4 is a choroid plexus-derived injury response gene: evidence for a biphasic response in early and late brain injury. PLoS One. 2011; 6(9):e24609. Podvin S, Gonzalez AM, Miller MC, Dang X, Botfield H, Donahue JE, Kurabi A, Boissaud-Cooke M, Rossi R, Leadbeater WE, Johanson CE, Coimbra R, Stopa EG, Eliceiri BP, Baird A. PMID: 21935431; PMCID: PMC3173480.

View in: PubMed Mentions: 34 Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals Cells
Solution structure of the carboxy-terminal Tudor domain from human Coilin. FEBS Lett. 2010 Oct 22; 584(20):4351-6. Shanbhag R, Kurabi A, Kwan JJ, Donaldson LW. PMID: 20875822.

View in: PubMed Mentions: 16 Fields:
Bio Biochemistry
Translation:Humans Cells
A nuclear localization signal at the SAM-SAM domain interface of AIDA-1 suggests a requirement for domain uncoupling prior to nuclear import. J Mol Biol. 2009 Oct 09; 392(5):1168-77. Kurabi A, Brener S, Mobli M, Kwan JJ, Donaldson LW. PMID: 19666031.

View in: PubMed Mentions: 15 Fields:
Mol Molecular Biology
Translation:Cells
Immobilization of beta-glucosidase on Eupergit C for lignocellulose hydrolysis. Biotechnol Lett. 2006 Feb; 28(3):151-6. Tu M, Zhang X, Kurabi A, Gilkes N, Mabee W, Saddler J. PMID: 16489491.

View in: PubMed Mentions: 13 Fields:
Bio Biotechnology
Translation:Cells
Weak lignin-binding enzymes: a novel approach to improve activity of cellulases for hydrolysis of lignocellulosics. Appl Biochem Biotechnol. 2005; 121-124:163-70. Berlin A, Gilkes N, Kurabi A, Bura R, Tu M, Kilburn D, Saddler J. PMID: 15917596.

View in: PubMed Mentions: 30 Fields:
Bio Biochemistry Bio Biotechnology
Translation:Cells
Enzymatic hydrolysis of steam-exploded and ethanol organosolv-pretreated Douglas-Firby novel and commercial fungal cellulases. Appl Biochem Biotechnol. 2005; 121-124:219-30. Kurabi A, Berlin A, Gilkes N, Kilburn D, Bura R, Robinson J, Markov A, Skomarovsky A, Gusakov A, Okunev O, Sinitsyn A, Gregg D, Xie D, Saddler J. PMID: 15917601.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry Bio Biotechnology
Translation:Animals Cells PHPublic Health