Arwa Kurabi

Title(s)	Associate Project Scientist, Otolaryngology
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
vCard	Download vCard

Research

Research Activities and Funding

Establishment of an animal model of human-specific responses to middle ear infection.
NIH R03DC014801Apr 5, 2016 - Mar 31, 2020
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Combinatorial protection of cochlear hair cells: not too little but not too much. Front Cell Neurosci. 2024; 18:1458720. Kurabi A, Pak K, Lee EJ, Ryan AF. PMID: 39355176; PMCID: PMC11442228.

View in: PubMed Mentions:
Anti-inflammatory response to 1,8-Cineol and associated microbial communities in Otitis media patients. Sci Rep. 2024 07 16; 14(1):16362. Leichtle A, Lupatsii M, Graspeuntner S, Jeschke S, Penxová Z, Kurabi A, Ryan AF, Rupp J, Pries R, Bruchhage KL. PMID: 39014066; PMCID: PMC11252366.

View in: PubMed Mentions: 1 Fields:
Sci Science
Translation:Humans Cells
Immunomodulatory Response of the Middle Ear Epithelial Cells in Otitis Media. Otol Neurotol. 2024 Mar 01; 45(3):e248-e255. Leffers D, Penxova Z, Kempin T, Därr M, Fleckner J, Hollfelder D, Ryan AF, Bruchhage KL, Kurabi A, Leichtle A. PMID: 38238924; PMCID: PMC10922874.

View in: PubMed Mentions: 1 Fields:
Neu Neurology Oto Otolaryngology
Translation:Humans Animals Cells
PANEL 3: Otitis media animal models, cell culture, tissue regeneration & pathophysiology. Int J Pediatr Otorhinolaryngol. 2024 Jan; 176:111814. Kurabi A, Dewan K, Kerschner JE, Leichtle A, Li JD, Santa Maria PL, Preciado D. PMID: 38101097.

View in: PubMed Mentions: Fields:
Oto Otolaryngology Ped Pediatrics
Translation:Humans Animals
Hearing rehabilitation and microbial shift after middle ear surgery with Vibrant Soundbridge in patients with chronic otitis media. Eur Arch Otorhinolaryngol. 2023 Jul; 280(7):3107-3118. Bruchhage KL, Lupatsii M, Möllenkolk F, Leffers D, Kurabi A, Jürgens T, Graspeuntner S, Hollfelder D, Leichtle A. PMID: 36662266; PMCID: PMC10220096.

View in: PubMed Mentions: 4 Fields:
Oto Otolaryngology
Translation:Humans
Resolution of otitis media in a humanized mouse model. Front Genet. 2022; 13:958540. Son YL, Pak K, Muradagha N, Heo KW, Leichtle A, Kurabi A. PMID: 36437913; PMCID: PMC9682244.

View in: PubMed Mentions: 2
The ECRG4 cleavage product augurin binds the endotoxin receptor and influences the innate immune response during otitis media. Front Genet. 2022; 13:932555. Kurabi A, Hur DG, Pak K, Gibson M, Webster NJG, Baird A, Eliceiri BP, Ryan AF. PMID: 36092940; PMCID: PMC9461705.

View in: PubMed Mentions:
Essential Role of the Innate Immune Adaptor RIP2 in the Response to Otitis Media. Front Genet. 2022; 13:893085. Kurabi A, Lee J, Pak K, Leichtle A, Ryan AF. PMID: 35903351; PMCID: PMC9315102.

View in: PubMed Mentions: 2
Immunomodulation as a Protective Strategy in Chronic Otitis Media. Front Cell Infect Microbiol. 2022; 12:826192. Leichtle A, Kurabi A, Leffers D, Därr M, Draf CS, Ryan AF, Bruchhage KL. PMID: 35433505; PMCID: PMC9005906.

View in: PubMed Mentions: 3 Fields:
Cel Cell Biology Com Communicable Diseases Mic Microbiology
Translation:Humans Animals
HB-EGF Plays a Pivotal Role in Mucosal Hyperplasia During Otitis Media Induced by a Viral Analog. Front Cell Infect Microbiol. 2022; 12:823714. Sakamoto T, Pak K, Chavez E, Ryan AF, Kurabi A. PMID: 35281434; PMCID: PMC8904902.

View in: PubMed Mentions: 2 Fields:
Cel Cell Biology Com Communicable Diseases Mic Microbiology
Translation:Humans Animals Cells
A transcytotic transport mechanism across the tympanic membrane. Sci Rep. 2022 01 19; 12(1):984. Kurabi A, Pak K, Chavez E, Doan J, Ryan AF. PMID: 35046419; PMCID: PMC8770641.

View in: PubMed Mentions: 2 Fields:
Sci Science
Translation:Animals Cells
Leukotriene B4 Is a Major Determinant of Leukocyte Recruitment During Otitis Media. Front Cell Infect Microbiol. 2021; 11:768815. Heo KW, Pak K, Kurabi A, Ryan AF. PMID: 35004347; PMCID: PMC8727869.

View in: PubMed Mentions: 1 Fields:
Cel Cell Biology Com Communicable Diseases Mic Microbiology
Translation:Animals Cells
A Screen of Autophagy Compounds Implicates the Proteasome in Mammalian Aminoglycoside-Induced Hair Cell Damage. Front Cell Dev Biol. 2021; 9:762751. Draf C, Wyrick T, Chavez E, Pak K, Kurabi A, Leichtle A, Dazert S, Ryan AF. PMID: 34765606; PMCID: PMC8576371.

View in: PubMed Mentions: 6
Immunohistochemical and qPCR Detection of SARS-CoV-2 in the Human Middle Ear Versus the Nasal Cavity: Case Series. Head Neck Pathol. 2022 Jun; 16(2):607-611. Kurabi A, Pak K, DeConde AS, Ryan AF, Yan CH. PMID: 34455569; PMCID: PMC8401349.

View in: PubMed Mentions: 5 Fields:
Neo Neoplasms Pat Pathology
Translation:Humans Cells
[Immunomodulation in Cholesteatoma]. Laryngorhinootologie. 2022 Apr; 101(4):310-319. Leichtle A, Leffers D, Daerr MG, Draf C, Kurabi A, Ryan AF, Rupp J, Bruchhage KL. PMID: 34233375.

View in: PubMed Mentions: 3 Fields:
Oto Otolaryngology
Translation:Humans Animals
Macrophage Depletion in CCR2-/- Mice Delays Bacterial Clearance and Enhances Neutrophil Infiltration in an Acute Otitis Media Model. J Infect Dis. 2021 02 03; 223(2):333-341. Hur DG, Kurabi A, Lim HW, Spriggs M, Pak K, Ryan AF. PMID: 32572481; PMCID: PMC7857354.

View in: PubMed Mentions: 4 Fields:
Com Communicable Diseases
Translation:Animals Cells
Molecular Screening Strategy to Identify a Non-invasive Delivery Mechanism for the Treatment of Middle Ear Disorders. Front Med (Lausanne). 2020; 7:503819. Kurabi A, Cooper M, Spriggs M, Xu Y, Schaerer D, Ryan AF. PMID: 33392211; PMCID: PMC7775502.

View in: PubMed Mentions:
A kinase inhibitor screen identifies signaling pathways regulating mucosal growth during otitis media. PLoS One. 2020; 15(8):e0235634. Noel J, Suzukawa K, Chavez E, Pak K, Wasserman SI, Kurabi A, Ryan AF. PMID: 32760078; PMCID: PMC7410257.

View in: PubMed Mentions: Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals Cells
Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection. Front Genet. 2020; 11:358. Ryan AF, Nasamran CA, Pak K, Draf C, Fisch KM, Webster N, Kurabi A. PMID: 32351546; PMCID: PMC7174727.

View in: PubMed Mentions: 16
Panel 8: Vaccines and immunology. Int J Pediatr Otorhinolaryngol. 2020 Mar; 130 Suppl 1:109839. Alderson MR, Murphy T, Pelton SI, Novotny LA, Hammitt LL, Kurabi A, Li JD, Thornton RB, Kirkham LS. PMID: 31948716; PMCID: PMC7153269.

View in: PubMed Mentions: 2 Fields:
Oto Otolaryngology Ped Pediatrics
Translation:Humans PHPublic Health
Panel 2- recent advance in otitis media bioinformatics. Int J Pediatr Otorhinolaryngol. 2020 Mar; 130 Suppl 1:109834. Preciado D, Li JD, Komatsu K, Kurabi A, Nino G, Val S, Vijayasekaran S, Ziv O, Hermansson A. PMID: 31899006; PMCID: PMC7184535.

View in: PubMed Mentions: Fields:
Oto Otolaryngology Ped Pediatrics
Translation:Humans
Role of the PI3K/AKT pathway and PTEN in otitis media. Exp Cell Res. 2020 02 01; 387(1):111758. Lee HH, Chin A, Pak K, Wasserman SI, Kurabi A, Ryan AF. PMID: 31837294; PMCID: PMC7824983.

View in: PubMed Mentions: 2 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Inflammation associated with noise-induced hearing loss. J Acoust Soc Am. 2019 11; 146(5):4020. Frye MD, Ryan AF, Kurabi A. PMID: 31795714; PMCID: PMC7480080.

View in: PubMed Mentions: 55 Fields:
Aud Audiology Spe Speech-Language Pathology
Translation:Humans Animals Cells
NOD1/NOD2-mediated recognition of non-typeable Haemophilus influenzae activates innate immunity during otitis media. Innate Immun. 2019 11; 25(8):503-512. Lee J, Leichtle A, Zuckerman E, Pak K, Spriggs M, Wasserman SI, Kurabi A. PMID: 31474163; PMCID: PMC6900663.

View in: PubMed Mentions: 8 Fields:
All Allergy and Immunology Bac Bacteriology
Translation:Humans Animals Cells
Lack of the hyaluronan receptor CD44 affects the course of bacterial otitis media and reduces leukocyte recruitment to the middle ear. BMC Immunol. 2019 06 21; 20(1):20. Lim HW, Pak K, Kurabi A, Ryan AF. PMID: 31226944; PMCID: PMC6588864.

View in: PubMed Mentions: 6 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
Active Transport of Peptides Across the Intact Human Tympanic Membrane. Sci Rep. 2018 08 07; 8(1):11815. Kurabi A, Schaerer D, Noack V, Bernhardt M, Pak K, Alexander T, Husseman J, Nguyen Q, Harris JP, Ryan AF. PMID: 30087425; PMCID: PMC6081404.

View in: PubMed Mentions: 9 Fields:
Sci Science
Translation:Humans Animals
Screening Mammalian Cochlear Hair Cells to Identify Critical Processes in Aminoglycoside-Mediated Damage. Front Cell Neurosci. 2018; 12:179. Lim HW, Pak K, Ryan AF, Kurabi A. PMID: 30013464; PMCID: PMC6036173.

View in: PubMed Mentions: 6
Screening antioxidants for the protection of cochlear sensory cells. Neural Regen Res. 2018 Jan; 13(1):62-64. Hur DG, Kurabi A, Ryan AF. PMID: 29451206; PMCID: PMC5840991.

View in: PubMed Mentions: 5
A kinase inhibitor library screen identifies novel enzymes involved in ototoxic damage to the murine organ of Corti. PLoS One. 2017; 12(10):e0186001. Ryals M, Pak K, Jalota R, Kurabi A, Ryan AF. PMID: 29049311; PMCID: PMC5648133.

View in: PubMed Mentions: 6 Fields:
Med Medicine (General)Sci Science
Translation:Animals
Otitis Media and Nasopharyngeal Colonization in ccl3-/- Mice. Infect Immun. 2017 11; 85(11). Deniffel D, Nuyen B, Pak K, Suzukawa K, Hung J, Kurabi A, Wasserman SI, Ryan AF. PMID: 28847849; PMCID: PMC5649018.

View in: PubMed Mentions: 10 Fields:
All Allergy and Immunology Com Communicable Diseases
Translation:Animals Cells
An Antioxidant Screen Identifies Candidates for Protection of Cochlear Hair Cells from Gentamicin Toxicity. Front Cell Neurosci. 2017; 11:242. Noack V, Pak K, Jalota R, Kurabi A, Ryan AF. PMID: 28867994; PMCID: PMC5563352.

View in: PubMed Mentions: 24
Optimisation of peptides that actively cross the tympanic membrane by random amino acid extension: a phage display study. J Drug Target. 2018 02; 26(2):127-134. Kurabi A, Schaerer D, Chang L, Pak K, Ryan AF. PMID: 28658990; PMCID: PMC6223256.

View in: PubMed Mentions: 6 Fields:
Pha Pharmacology
Translation:Animals Cells
Panel 5: Immunology. Otolaryngol Head Neck Surg. 2017 04; 156(4_suppl):S63-S75. Kyd JM, Hotomi M, Kono M, Kurabi A, Pichichero M, Ryan A, Swords WE, Thornton R. PMID: 28372530.

View in: PubMed Mentions: 2 Fields:
Gen General Surgery Oto Otolaryngology
Translation:Humans
Panel 8: Report on Recent Advances in Molecular and Cellular Biochemistry. Otolaryngol Head Neck Surg. 2017 04; 156(4_suppl):S106-S113. Preciado D, Granath A, Lin J, Val S, Kurabi A, Johnston N, Vijayasekaran S, Valdez T, Depireux D, Hermansson A. PMID: 28372528.

View in: PubMed Mentions: 2 Fields:
Gen General Surgery Oto Otolaryngology
Translation:Animals Cells
Peptides actively transported across the tympanic membrane: Functional and structural properties. PLoS One. 2017; 12(2):e0172158. Kurabi A, Beasley KA, Chang L, McCann J, Pak K, Ryan AF. PMID: 28234923; PMCID: PMC5325213.

View in: PubMed Mentions: 9 Fields:
Med Medicine (General)Sci Science
Translation:Animals Cells
Cellular mechanisms of noise-induced hearing loss. Hear Res. 2017 06; 349:129-137. Kurabi A, Keithley EM, Housley GD, Ryan AF, Wong AC. PMID: 27916698; PMCID: PMC6750278.

View in: PubMed Mentions: 136 Fields:
Aud Audiology
Translation:Humans Animals Cells PHPublic Health
Both canonical and non-canonical NF-κB activation contribute to the proliferative response of the middle ear mucosa during bacterial infection. Innate Immun. 2016 11; 22(8):626-634. Cho CG, Pak K, Webster N, Kurabi A, Ryan AF. PMID: 27655045; PMCID: PMC5333768.

View in: PubMed Mentions: 6 Fields:
All Allergy and Immunology Bac Bacteriology
Translation:Humans Animals Cells
Discovery of a Biological Mechanism of Active Transport through the Tympanic Membrane to the Middle Ear. Sci Rep. 2016 Mar 07; 6:22663. Kurabi A, Pak KK, Bernhardt M, Baird A, Ryan AF. PMID: 26946957; PMCID: PMC4780071.

View in: PubMed Mentions: 14 Fields:
Sci Science
Translation:Animals
Innate Immunity: Orchestrating Inflammation and Resolution of Otitis Media. Curr Allergy Asthma Rep. 2016 Jan; 16(1):6. Kurabi A, Pak K, Ryan AF, Wasserman SI. PMID: 26732809; PMCID: PMC6752202.

View in: PubMed Mentions: 21 Fields:
All Allergy and Immunology Pul Pulmonary Medicine
Translation:Humans
Esophageal cancer-related gene-4 (ECRG4) interactions with the innate immunity receptor complex. Inflamm Res. 2015 Feb; 64(2):107-18. Podvin S, Dang X, Meads M, Kurabi A, Costantini T, Eliceiri BP, Baird A, Coimbra R. PMID: 25511108; PMCID: PMC4301958.

View in: PubMed Mentions: 14 Fields:
All Allergy and Immunology Pat Pathology
Translation:Humans Cells
A mouse model of otitis media identifies HB-EGF as a mediator of inflammation-induced mucosal proliferation. PLoS One. 2014; 9(7):e102739. Suzukawa K, Tomlin J, Pak K, Chavez E, Kurabi A, Baird A, Wasserman SI, Ryan AF. PMID: 25033458; PMCID: PMC4102546.

View in: PubMed Mentions: 13 Fields:
Med Medicine (General)Sci Science
Translation:Animals
The inflammasome adaptor ASC contributes to multiple innate immune processes in the resolution of otitis media. Innate Immun. 2015 Feb; 21(2):203-14. Kurabi A, Lee J, Wong C, Pak K, Hoffman HM, Ryan AF, Wasserman SI. PMID: 24652041; PMCID: PMC4379507.

View in: PubMed Mentions: 15 Fields:
All Allergy and Immunology Bac Bacteriology
Translation:Humans Animals Cells
Esophageal cancer-related gene 4 at the interface of injury, inflammation, infection, and malignancy. Gastrointest Cancer. 2014; 2014(4):131-142. Baird A, Lee J, Podvin S, Kurabi A, Dang X, Coimbra R, Costantini T, Bansal V, Eliceiri BP. PMID: 25580077; PMCID: PMC4287990.

View in: PubMed Mentions: 16
Solution structure and peptide binding of the PTB domain from the AIDA1 postsynaptic signaling scaffolding protein. PLoS One. 2013; 8(6):e65605. Smirnova E, Shanbhag R, Kurabi A, Mobli M, Kwan JJ, Donaldson LW. PMID: 23799029; PMCID: PMC3683042.

View in: PubMed Mentions: 6 Fields:
Med Medicine (General)Sci Science
Translation:Humans Cells
Ecrg4 attenuates the inflammatory proliferative response of mucosal epithelial cells to infection. PLoS One. 2013; 8(4):e61394. Kurabi A, Pak K, Dang X, Coimbra R, Eliceiri BP, Ryan AF, Baird A. PMID: 23626679; PMCID: PMC3634077.

View in: PubMed Mentions: 25 Fields:
Med Medicine (General)Sci Science
Translation:Animals Cells
Esophageal cancer related gene-4 is a choroid plexus-derived injury response gene: evidence for a biphasic response in early and late brain injury. PLoS One. 2011; 6(9):e24609. Podvin S, Gonzalez AM, Miller MC, Dang X, Botfield H, Donahue JE, Kurabi A, Boissaud-Cooke M, Rossi R, Leadbeater WE, Johanson CE, Coimbra R, Stopa EG, Eliceiri BP, Baird A. PMID: 21935431; PMCID: PMC3173480.

View in: PubMed Mentions: 32 Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals Cells
Solution structure of the carboxy-terminal Tudor domain from human Coilin. FEBS Lett. 2010 Oct 22; 584(20):4351-6. Shanbhag R, Kurabi A, Kwan JJ, Donaldson LW. PMID: 20875822.

View in: PubMed Mentions: 15 Fields:
Bio Biochemistry
Translation:Humans Cells
A nuclear localization signal at the SAM-SAM domain interface of AIDA-1 suggests a requirement for domain uncoupling prior to nuclear import. J Mol Biol. 2009 Oct 09; 392(5):1168-77. Kurabi A, Brener S, Mobli M, Kwan JJ, Donaldson LW. PMID: 19666031.

View in: PubMed Mentions: 15 Fields:
Mol Molecular Biology
Translation:Cells
Immobilization of beta-glucosidase on Eupergit C for lignocellulose hydrolysis. Biotechnol Lett. 2006 Feb; 28(3):151-6. Tu M, Zhang X, Kurabi A, Gilkes N, Mabee W, Saddler J. PMID: 16489491.

View in: PubMed Mentions: 13 Fields:
Bio Biotechnology
Translation:Cells
Enzymatic hydrolysis of steam-exploded and ethanol organosolv-pretreated Douglas-Firby novel and commercial fungal cellulases. Appl Biochem Biotechnol. 2005; 121-124:219-30. Kurabi A, Berlin A, Gilkes N, Kilburn D, Bura R, Robinson J, Markov A, Skomarovsky A, Gusakov A, Okunev O, Sinitsyn A, Gregg D, Xie D, Saddler J. PMID: 15917601.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry Bio Biotechnology
Translation:Animals Cells PHPublic Health
Weak lignin-binding enzymes: a novel approach to improve activity of cellulases for hydrolysis of lignocellulosics. Appl Biochem Biotechnol. 2005; 121-124:163-70. Berlin A, Gilkes N, Kurabi A, Bura R, Tu M, Kilburn D, Saddler J. PMID: 15917596.

View in: PubMed Mentions: 29 Fields:
Bio Biochemistry Bio Biotechnology
Translation:Cells