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Fred Gage

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentNeurosciences
Address9500 Gilman Drive #0932
La Jolla CA 92093
Phone858-453-4100
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    Collapse Research 
    Collapse Research Activities and Funding
    Combinatorial Actions of Genetic Variants and Gender Bias of Alzherimer's Disease
    NIH/NIA R01AG057706Sep 30, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    Dynamics of activity-induced transcription in single dentate granule cells
    NIH/NIMH R01MH114030Aug 1, 2017 - May 31, 2022
    Role: Principal Investigator
    Assessing cellular aging in old and rejuvenated neurons from Alzheimer patients
    NIH/NIA R01AG056306Jul 15, 2017 - Apr 30, 2022
    Role: Principal Investigator
    iPSC-based platform development for major psychiatric disorder modeling and discovery
    NIH/NIMH U19MH106434Aug 17, 2016 - May 31, 2021
    Role: Co-Principal Investigator
    3/3-Schizophrenia Genetics and Brain Somatic Mosaicism
    NIH/NIMH U01MH106882Apr 20, 2015 - Jan 31, 2020
    Role: Principal Investigator
    Exploring Human-Induced Pluripotent Stem Cells for Alzheimer's Disease Research
    NIH/NIA RF1AG042985Sep 1, 2012 - Aug 31, 2014
    Role: Co-Principal Investigator
    Development and Analysis of hiPSCs for Studies on Addiction
    NIH/NIDA R21DA032986Sep 30, 2011 - Jul 31, 2014
    Role: Co-Principal Investigator
    Single-Cell Approaches to Reveal How Jumping Genes Individualize Neural Circuits
    NIH/NIMH R01MH095741Sep 20, 2011 - Jun 30, 2016
    Role: Principal Investigator
    DISTINCTIVE SPATIOTEMPORAL MAP OF TARGET ACTIVATION BY YOUNG NEURONS OF THE ADULT
    NIH/FIC R03TW008607Jan 1, 2011 - Jun 30, 2014
    Role: Co-Principal Investigator
    Functional Analysis of Adult Hippocampal Neurogenesis
    NIH/NIMH R01MH090258Apr 2, 2010 - Jan 31, 2015
    Role: Principal Investigator
    L1 Retrotransposon and Neural Diversity
    NIH/NIMH R01MH088485Aug 12, 2009 - Oct 30, 2013
    Role: Principal Investigator
    The Role of MeCP2 in L1 Neuronal Retrotransposition
    NIH/NIMH R56MH082070Sep 30, 2008 - Sep 29, 2009
    Role: Principal Investigator
    Translational Research of AAV-IGF-1 Gene Therapy for ALS
    NIH/NINDS U01NS048925Sep 15, 2005 - Feb 28, 2009
    Role: Principal Investigator
    Role of Astrocyte-Derived Wnts in Adult Neurogenesis
    NIH/NINDS R01NS050217May 18, 2005 - Apr 30, 2010
    Role: Principal Investigator
    smRNA-Mediated Regulation of Adult Neural Stem Cell Fate
    NIH/NINDS R01NS052842May 18, 2005 - Apr 30, 2009
    Role: Principal Investigator
    Neurophysiology of Adult Substantia Nigra Stem Cells
    NIH/FIC R03TW006130Jan 1, 2003 - Dec 31, 2005
    Role: Principal Investigator
    Gene Targeting and Regulation for Neurological Disease
    NIH/NIA R01AG021876Aug 15, 2002 - Jul 31, 2007
    Role: Principal Investigator
    Function of Stem Cell-Derived Neurons in the Aging Brain
    NIH/NIA R01AG020938Apr 1, 2002 - Mar 31, 2008
    Role: Principal Investigator
    Conference on Stem Cells: Origins, Fate and Functions
    NIH/NINDS R13NS042933Jan 1, 2002 - Dec 31, 2002
    Role: Principal Investigator
    THERAPEUTIC POTENTIALS OF CNS STEM CELLS
    NIH/NINDS R13NS039557Jul 1, 1999 - Jun 30, 2000
    Role: Principal Investigator
    NEURONAL PRECURSOR CELLS FOR TRANSPLANT AFTER CNS TRAUMA
    NIH/NINDS N01NS062348Sep 30, 1996 - Sep 29, 2002
    Role: Principal Investigator
    NEURONAL PRECURSOR CELLS FOR TRANSPLANTATION AFTER CNS
    NIH/NINDS N01NS062349Sep 30, 1996 - Sep 29, 2002
    Role: Co-Principal Investigator
    Training in the Neuroplasticity of Aging
    NIH/NIA T32AG000216Sep 30, 1992 - Apr 30, 2017
    Role: Co-Principal Investigator
    Gene Therapy for Alzheimer's Disease
    NIH/NIA P01AG010435Sep 30, 1991 - Mar 31, 2015
    Role: Co-Principal Investigator
    Cell Genesis in the Intact and Injured Substantia Nigra
    NIH/NIA R01AG008514Jul 1, 1989 - Jun 30, 2006
    Role: Principal Investigator
    GRAFTING GENETICALLY MODIFIED CELLS TO THE BRAIN
    NIH/NIA R37AG008514Jul 1, 1989 - Jun 30, 2001
    Role: Principal Investigator
    CHARACTERIZATION &UTILIZATION OF ADULT PROGENITOR CELLS
    NIH/NIA R01AG006088Jul 1, 1985 - Feb 28, 2002
    Role: Principal Investigator
    EMBRYONIC NERVE CELL TRANSPLANTATION IN BRAINS OF AGED
    NIH/NIA R01AG003766Apr 1, 1983 - Jun 30, 1985
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sommer A, Maxreiter F, Krach F, Fadler T, Grosch J, Maroni M, Graef D, Eberhardt E, Riemenschneider MJ, Yeo GW, Kohl Z, Xiang W, Gage F, Winkler J, Prots I, Winner B. Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease. Cell Stem Cell. 2018 Jul 05; 23(1):123-131.e6. PMID: 29979986.
      View in: PubMed
    2. Kim Y, Zheng X, Ansari Z, Bunnell MC, Herdy JR, Traxler L, Lee H, Paquola ACM, Blithikioti C, Ku M, Schlachetzki JCM, Winkler J, Edenhofer F, Glass CK, Paucar AA, Jaeger BN, Pham S, Boyer L, Campbell BC, Hunter T, Mertens J, Gage F. Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile. Cell Rep. 2018 May 29; 23(9):2550-2558. PMID: 29847787.
      View in: PubMed
    3. Strnadel J, Carromeu C, Bardy C, Navarro M, Platoshyn O, Glud AN, Marsala S, Kafka J, Miyanohara A, Kato T, Tadokoro T, Hefferan MP, Kamizato K, Yoshizumi T, Juhas S, Juhasova J, Ho CS, Kheradmand T, Chen P, Bohaciakova D, Hruska-Plochan M, Todd AJ, Driscoll SP, Glenn TD, Pfaff SL, Klima J, Ciacci J, Curtis E, Gage F, Bui J, Yamada K, Muotri AR, Marsala M. Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs. Sci Transl Med. 2018 May 09; 10(440). PMID: 29743351.
      View in: PubMed
    4. Sarkar A, Mei A, Paquola ACM, Stern S, Bardy C, Klug JR, Kim S, Neshat N, Kim HJ, Ku M, Shokhirev MN, Adamowicz DH, Marchetto MC, Jappelli R, Erwin JA, Padmanabhan K, Shtrahman M, Jin X, Gage F. Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro. Cell Stem Cell. 2018 May 03; 22(5):684-697.e9. PMID: 29727680.
      View in: PubMed
    5. Stern S, Linker S, Vadodaria KC, Marchetto MC, Gage F. Prediction of response to drug therapy in psychiatric disorders. Open Biol. 2018 May; 8(5). PMID: 29794033.
      View in: PubMed
    6. Erwin JA, Paquola ACM, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FIA, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage F. Author Correction: L1-associated genomic regions are deleted in somatic cells of the healthy human brain. Nat Neurosci. 2018 Apr 27. PMID: 29703932.
      View in: PubMed
    7. Toda T, Parylak SL, Linker SB, Gage F. The role of adult hippocampal neurogenesis in brain health and disease. Mol Psychiatry. 2018 Apr 20. PMID: 29679070.
      View in: PubMed
    8. Mansour AA, Gonçalves JT, Bloyd CW, Li H, Fernandes S, Quang D, Johnston S, Parylak SL, Jin X, Gage F. An in vivo model of functional and vascularized human brain organoids. Nat Biotechnol. 2018 Jun; 36(5):432-441. PMID: 29658944.
      View in: PubMed
    9. Bedrosian TA, Quayle C, Novaresi N, Gage F. Early life experience drives structural variation of neural genomes in mice. Science. 2018 03 23; 359(6382):1395-1399. PMID: 29567711.
      View in: PubMed
    10. Zheng Y, Shen W, Zhang J, Yang B, Liu YN, Qi H, Yu X, Lu SY, Chen Y, Xu YZ, Li Y, Gage F, Mi S, Yao J. Author Correction: CRISPR interference-based specific and efficient gene inactivation in the brain. Nat Neurosci. 2018 Mar 15. PMID: 29545585.
      View in: PubMed
    11. Zheng Y, Shen W, Zhang J, Yang B, Liu YN, Qi H, Yu X, Lu SY, Chen Y, Xu YZ, Li Y, Gage F, Mi S, Yao J. CRISPR interference-based specific and efficient gene inactivation in the brain. Nat Neurosci. 2018 Mar; 21(3):447-454. PMID: 29403034.
      View in: PubMed
    12. Vadodaria KC, Amatya DN, Marchetto MC, Gage F. Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward. Genome Med. 2018 Jan 04; 10(1):1. PMID: 29301565.
      View in: PubMed
    13. Toda T, Gage F. Review: adult neurogenesis contributes to hippocampal plasticity. Cell Tissue Res. 2017 Nov 29. PMID: 29185071.
      View in: PubMed
    14. Jaeger BN, Parylak SL, Gage F. Mechanisms of dietary flavonoid action in neuronal function and neuroinflammation. Mol Aspects Med. 2017 Nov 09. PMID: 29117513.
      View in: PubMed
    15. Erwin JA, Paquola ACM, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FIA, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage F. Corrigendum: L1-associated genomic regions are deleted in somatic cells of the healthy human brain. Nat Neurosci. 2017 09 28; 20(10):1427. PMID: 28949329.
      View in: PubMed
    16. Toda T, Hsu JY, Linker SB, Hu L, Schafer ST, Mertens J, Jacinto FV, Hetzer MW, Gage F. Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells. Cell Stem Cell. 2017 Nov 02; 21(5):618-634.e7. PMID: 28919367.
      View in: PubMed
    17. Topol A, Zhu S, Hartley BJ, English J, Hauberg ME, Tran N, Rittenhouse CA, Simone A, Ruderfer DM, Johnson J, Readhead B, Hadas Y, Gochman PA, Wang YC, Shah H, Cagney G, Rapoport J, Gage F, Dudley JT, Sklar P, Mattheisen M, Cotter D, Fang G, Brennand KJ. Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells. Cell Rep. 2017 Sep 05; 20(10):2525. PMID: 28877483.
      View in: PubMed
    18. Vadodaria KC, Stern S, Marchetto MC, Gage F. Serotonin in psychiatry: in vitro disease modeling using patient-derived neurons. Cell Tissue Res. 2018 01; 371(1):161-170. PMID: 28812143.
      View in: PubMed
    19. Linker SB, Marchetto MC, Narvaiza I, Denli AM, Gage F. Examining non-LTR retrotransposons in the context of the evolving primate brain. BMC Biol. 2017 Aug 11; 15(1):68. PMID: 28800766.
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    20. Newkirk SJ, Lee S, Grandi FC, Gaysinskaya V, Rosser JM, Vanden Berg N, Hogarth CA, Marchetto MCN, Muotri AR, Griswold MD, Ye P, Bortvin A, Gage F, Boeke JD, An W. Intact piRNA pathway prevents L1 mobilization in male meiosis. Proc Natl Acad Sci U S A. 2017 Jul 11; 114(28):E5635-E5644. PMID: 28630288.
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    21. Santos R, Vadodaria KC, Jaeger BN, Mei A, Lefcochilos-Fogelquist S, Mendes APD, Erikson G, Shokhirev M, Randolph-Moore L, Fredlender C, Dave S, Oefner R, Fitzpatrick C, Pena M, Barron JJ, Ku M, Denli AM, Kerman BE, Charnay P, Kelsoe JR, Marchetto MC, Gage F. Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 06 06; 8(6):1757-1769. PMID: 28591655.
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    22. Gosselin D, Skola D, Coufal NG, Holtman IR, Schlachetzki JCM, Sajti E, Jaeger BN, O'Connor C, Fitzpatrick C, Pasillas MP, Pena M, Adair A, Gonda DD, Levy ML, Ransohoff RM, Gage F, Glass CK. An environment-dependent transcriptional network specifies human microglia identity. Science. 2017 06 23; 356(6344). PMID: 28546318.
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    23. Ishii S, Torii M, Son AI, Rajendraprasad M, Morozov YM, Kawasawa YI, Salzberg AC, Fujimoto M, Brennand K, Nakai A, Mezger V, Gage F, Rakic P, Hashimoto-Torii K. Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling. Nat Commun. 2017 May 02; 8:15157. PMID: 28462912.
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    24. Franks TM, Benner C, Narvaiza I, Marchetto MCN, Young JM, Malik HS, Gage F, Hetzer MW. Corrigendum: Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes Dev. 2017 04 15; 31(8):845. PMID: 28512238.
      View in: PubMed
    25. Lacar B, Linker SB, Jaeger BN, Krishnaswami SR, Barron JJ, Kelder MJ, Parylak SL, Paquola AC, Venepally P, Novotny M, O'Connor C, Fitzpatrick C, Erwin JA, Hsu JY, Husband D, McConnell MJ, Lasken R, Gage F. Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation. Nat Commun. 2017 Mar 17; 8:15047. PMID: 28303884.
      View in: PubMed
    26. Ramsay L, Marchetto MC, Caron M, Chen SH, Busche S, Kwan T, Pastinen T, Gage F, Bourque G. Conserved expression of transposon-derived non-coding transcripts in primate stem cells. BMC Genomics. 2017 02 28; 18(1):214. PMID: 28245871.
      View in: PubMed
    27. Kim Y, Santos R, Gage F, Marchetto MC. Molecular Mechanisms of Bipolar Disorder: Progress Made and Future Challenges. Front Cell Neurosci. 2017; 11:30. PMID: 28261061.
      View in: PubMed
    28. Adamowicz DH, Roy S, Salmon DP, Galasko DR, Hansen LA, Masliah E, Gage F. Hippocampal a-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology. J Neurosci. 2017 Feb 15; 37(7):1675-1684. PMID: 28039370.
      View in: PubMed
    29. Paquola ACM, Erwin JA, Gage F. Insights into the role of somatic mosaicism in the brain. Curr Opin Syst Biol. 2017 Feb; 1:90-94. PMID: 29226270.
      View in: PubMed
    30. Han J, Gage F. A role for miR-19 in the migration of adult-born neurons and schizophrenia. Neurogenesis (Austin). 2016; 3(1):e1251873. PMID: 28405585.
      View in: PubMed
    31. Gonçalves JT, Schafer ST, Gage F. Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior. Cell. 2016 Nov 03; 167(4):897-914. PMID: 27814520.
      View in: PubMed
    32. Vadodaria KC, Marchetto MC, Mertens J, Gage F. Generating human serotonergic neurons in vitro: Methodological advances. Bioessays. 2016 11; 38(11):1123-1129. PMID: 27716980.
      View in: PubMed
    33. Erwin JA, Paquola AC, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FI, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage F. L1-associated genomic regions are deleted in somatic cells of the healthy human brain. Nat Neurosci. 2016 12; 19(12):1583-1591. PMID: 27618310.
      View in: PubMed
    34. Du H, Deng W, Aimone JB, Ge M, Parylak S, Walch K, Zhang W, Cook J, Song H, Wang L, Gage F, Mu Y. Dopaminergic inputs in the dentate gyrus direct the choice of memory encoding. Proc Natl Acad Sci U S A. 2016 09 13; 113(37):E5501-10. PMID: 27573822; PMCID: PMC5027420 [Available on 03/13/17].
    35. Chailangkarn T, Trujillo CA, Freitas BC, Hrvoj-Mihic B, Herai RH, Yu DX, Brown TT, Marchetto MC, Bardy C, McHenry L, Stefanacci L, Järvinen A, Searcy YM, DeWitt M, Wong W, Lai P, Ard MC, Hanson KL, Romero S, Jacobs B, Dale AM, Dai L, Korenberg JR, Gage F, Bellugi U, Halgren E, Semendeferi K, Muotri AR. A human neurodevelopmental model for Williams syndrome. Nature. 2016 08 18; 536(7616):338-43. PMID: 27509850.
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    36. Nuttle X, Giannuzzi G, Duyzend MH, Schraiber JG, Narvaiza I, Sudmant PH, Penn O, Chiatante G, Malig M, Huddleston J, Benner C, Camponeschi F, Ciofi-Baffoni S, Stessman HA, Marchetto MC, Denman L, Harshman L, Baker C, Raja A, Penewit K, Janke N, Tang WJ, Ventura M, Banci L, Antonacci F, Akey JM, Amemiya CT, Gage F, Reymond A, Eichler EE. Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility. Nature. 2016 08 11; 536(7615):205-9. PMID: 27487209; PMCID: PMC4988886 [Available on 02/11/17].
    37. van den Hurk M, Kenis G, Bardy C, van den Hove DL, Gage F, Steinbusch HW, Rutten BP. Transcriptional and epigenetic mechanisms of cellular reprogramming to induced pluripotency. Epigenomics. 2016 08; 8(8):1131-49. PMID: 27419933.
      View in: PubMed
    38. Padmanabhan K, Osakada F, Tarabrina A, Kizer E, Callaway EM, Gage F, Sejnowski TJ. Diverse Representations of Olfactory Information in Centrifugal Feedback Projections. J Neurosci. 2016 07 13; 36(28):7535-45. PMID: 27413162; PMCID: PMC4945671.
    39. Han J, Kim HJ, Schafer ST, Paquola A, Clemenson GD, Toda T, Oh J, Pankonin AR, Lee BS, Johnston ST, Sarkar A, Denli AM, Gage F. Functional Implications of miR-19 in the Migration of Newborn Neurons in the Adult Brain. Neuron. 2016 07 06; 91(1):79-89. PMID: 27387650.
      View in: PubMed
    40. Gage F, Guarente LP, Wagers AJ. Aging and Rejuvenation: Insights from Rusty Gage, Leonard Guarente, and Amy Wagers. Trends Mol Med. 2016 08; 22(8):633-634. PMID: 27396512.
      View in: PubMed
    41. Marchetto MC, Belinson H, Tian Y, Freitas BC, Fu C, Vadodaria K, Beltrao-Braga P, Trujillo CA, Mendes APD, Padmanabhan K, Nunez Y, Ou J, Ghosh H, Wright R, Brennand K, Pierce K, Eichenfield L, Pramparo T, Eyler L, Barnes CC, Courchesne E, Geschwind DH, Gage F, Wynshaw-Boris A, Muotri AR. Altered proliferation and networks in neural cells derived from idiopathic autistic individuals. Mol Psychiatry. 2017 Jun; 22(6):820-835. PMID: 27378147.
      View in: PubMed
    42. Lacar B, Linker SB, Jaeger BN, Krishnaswami SR, Barron JJ, Kelder MJ, Parylak SL, Paquola AC, Venepally P, Novotny M, O'Connor C, Fitzpatrick C, Erwin JA, Hsu JY, Husband D, McConnell MJ, Lasken R, Gage F. Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation. Nat Commun. 2016 Jun 14; 7:12020. PMID: 27295945; PMCID: PMC4911670.
    43. Zheng X, Boyer L, Jin M, Mertens J, Kim Y, Ma L, Ma L, Hamm M, Gage F, Hunter T. Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation. Elife. 2016 06 10; 5. PMID: 27282387; PMCID: PMC4963198.
    44. Bedrosian TA, Linker S, Gage F. Environment-driven somatic mosaicism in brain disorders. Genome Med. 2016 05 23; 8(1):58. PMID: 27215330; PMCID: PMC4877941.
    45. Mertens J, Marchetto MC, Bardy C, Gage F. Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience. Nat Rev Neurosci. 2016 07; 17(7):424-37. PMID: 27194476.
      View in: PubMed
    46. Poo MM, Pignatelli M, Ryan TJ, Tonegawa S, Bonhoeffer T, Martin KC, Rudenko A, Tsai LH, Tsien RW, Fishell G, Mullins C, Gonçalves JT, Shtrahman M, Johnston ST, Gage F, Dan Y, Long J, Buzsáki G, Stevens C. What is memory? The present state of the engram. BMC Biol. 2016 05 19; 14:40. PMID: 27197636.
      View in: PubMed
    47. Franks TM, Benner C, Narvaiza I, Marchetto MC, Young JM, Malik HS, Gage F, Hetzer MW. Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes Dev. 2016 05 15; 30(10):1155-71. PMID: 27198230; PMCID: PMC4888837.
    48. Oedegaard KJ, Alda M, Anand A, Andreassen OA, Balaraman Y, Berrettini WH, Bhattacharjee A, Brennand KJ, Burdick KE, Calabrese JR, Calkin CV, Claasen A, Coryell WH, Craig D, DeModena A, Frye M, Gage F, Gao K, Garnham J, Gershon E, Jakobsen P, Leckband SG, McCarthy MJ, McInnis MG, Maihofer AX, Mertens J, Morken G, Nievergelt CM, Nurnberger J, Pham S, Schoeyen H, Shekhtman T, Shilling PD, Szelinger S, Tarwater B, Yao J, Zandi PP, Kelsoe JR. The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample. BMC Psychiatry. 2016 May 05; 16:129. PMID: 27150464; PMCID: PMC4857276.
    49. Gonçalves JT, Bloyd CW, Shtrahman M, Johnston ST, Schafer ST, Parylak SL, Tran T, Chang T, Gage F. In vivo imaging of dendritic pruning in dentate granule cells. Nat Neurosci. 2016 06; 19(6):788-91. PMID: 27135217; PMCID: PMC4941946 [Available on 11/02/16].
    50. Topol A, Zhu S, Hartley BJ, English J, Hauberg ME, Tran N, Rittenhouse CA, Simone A, Ruderfer DM, Johnson J, Readhead B, Hadas Y, Gochman PA, Wang YC, Shah H, Cagney G, Rapoport J, Gage F, Dudley JT, Sklar P, Mattheisen M, Cotter D, Fang G, Brennand KJ. Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells. Cell Rep. 2016 05 03; 15(5):1024-1036. PMID: 27117414; PMCID: PMC4856588.
    51. Lacar B, Linker SB, Jaeger BN, Krishnaswami S, Barron J, Kelder M, Parylak S, Paquola A, Venepally P, Novotny M, O'Connor C, Fitzpatrick C, Erwin J, Hsu JY, Husband D, McConnell MJ, Lasken R, Gage F. Nuclear RNA-seq of single neurons reveals molecular signatures of activation. Nat Commun. 2016 Apr 19; 7:11022. PMID: 27090946; PMCID: PMC4838832.
    52. Harrison BJ, Venkat G, Lamb JL, Hutson TH, Drury C, Rau KK, Bunge MB, Mendell LM, Gage F, Johnson RD, Hill CE, Rouchka EC, Moon LD, Petruska JC. The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity. J Neurosci. 2016 Apr 13; 36(15):4259-75. PMID: 27076424; PMCID: PMC4829650 [Available on 10/13/16].
    53. Ettle B, Kerman BE, Valera E, Gillmann C, Schlachetzki JC, Reiprich S, Büttner C, Ekici AB, Reis A, Wegner M, Bäuerle T, Riemenschneider MJ, Masliah E, Gage F, Winkler J. a-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy. Acta Neuropathol. 2016 Jul; 132(1):59-75. PMID: 27059609; PMCID: PMC4912450 [Available on 07/01/17].
    54. Otani T, Marchetto MC, Gage F, Simons BD, Livesey FJ. 2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size. Cell Stem Cell. 2016 Apr 07; 18(4):467-80. PMID: 27049876; PMCID: PMC4826446.
    55. Zheng X, Boyer L, Jin M, Kim Y, Fan W, Bardy C, Berggren T, Evans RM, Gage F, Hunter T. Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration. Elife. 2016 03 23; 5. PMID: 27008180; PMCID: PMC4846388.
    56. Mishra HK, Prots I, Havlicek S, Kohl Z, Perez-Branguli F, Boerstler T, Anneser L, Minakaki G, Wend H, Hampl M, Leone M, Brückner M, Klucken J, Reis A, Boyer L, Schuierer G, Behrens J, Lampert A, Engel FB, Gage F, Winkler J, Winner B. GSK3ß-dependent dysregulation of neurodevelopment in SPG11-patient iPSC model. Ann Neurol. 2016 Mar 11. PMID: 26971897.
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    57. Weissman IL, Gage F. A Mechanism for Somatic Brain Mosaicism. Cell. 2016 Feb 11; 164(4):593-5. PMID: 26871622.
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    58. Agre P, Bertozzi C, Bissell M, Campbell KP, Cummings RD, Desai UR, Estes M, Flotte T, Fogleman G, Gage F, Ginsburg D, Gordon JI, Hart G, Hascall V, Kiessling L, Kornfeld S, Lowe J, Magnani J, Mahal LK, Medzhitov R, Roberts RJ, Sackstein R, Sarkar R, Schnaar R, Schwartz N, Varki A, Walt D, Weissman I. Training the next generation of biomedical investigators in glycosciences. J Clin Invest. 2016 Feb; 126(2):405-8. PMID: 26829621; PMCID: PMC4731185 [Available on 02/01/17].
    59. Tang X, Kim J, Zhou L, Wengert E, Zhang L, Wu Z, Carromeu C, Muotri AR, Marchetto MC, Gage F, Chen G. KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):751-6. PMID: 26733678; PMCID: PMC4725523.
    60. Sarkar A, Marchetto MC, Gage F. Synaptic activity: An emerging player in schizophrenia. Brain Res. 2017 02 01; 1656:68-75. PMID: 26723567.
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    67. Denli AM, Narvaiza I, Kerman BE, Pena M, Benner C, Marchetto MC, Diedrich JK, Aslanian A, Ma J, Moresco JJ, Moore L, Hunter T, Saghatelian A, Gage F. Primate-specific ORF0 contributes to retrotransposon-mediated diversity. Cell. 2015 Oct 22; 163(3):583-93. PMID: 26496605.
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    69. Mertens J, Paquola ACM, Ku M, Hatch E, Böhnke L, Ladjevardi S, McGrath S, Campbell B, Lee H, Herdy JR, Gonçalves JT, Toda T, Kim Y, Winkler J, Yao J, Hetzer MW, Gage F. Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. Cell Stem Cell. 2015 Dec 03; 17(6):705-718. PMID: 26456686.
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    75. Jovicic A, Mertens J, Boeynaems S, Bogaert E, Chai N, Yamada SB, Paul JW, Sun S, Herdy JR, Bieri G, Kramer NJ, Gage F, Van Den Bosch L, Robberecht W, Gitler AD. Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS. Nat Neurosci. 2015 Sep; 18(9):1226-9. PMID: 26308983; PMCID: PMC4552077.
    76. Kempermann G, Song H, Gage F. Neurogenesis in the Adult Hippocampus. Cold Spring Harb Perspect Biol. 2015 Sep 01; 7(9):a018812. PMID: 26330519.
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    77. Firth AL, Menon T, Parker GS, Qualls SJ, Lewis BM, Ke E, Dargitz CT, Wright R, Khanna A, Gage F, Verma IM. Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs. Cell Rep. 2015 Sep 01; 12(9):1385-90. PMID: 26299960; PMCID: PMC4559351.
    78. Han J, Sarkar A, Gage F. MIR137: big impacts from small changes. Nat Neurosci. 2015 Jul; 18(7):931-3. PMID: 26108719.
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    83. Pei L, Mu Y, Leblanc M, Alaynick W, Barish GD, Pankratz M, Tseng TW, Kaufman S, Liddle C, Yu RT, Downes M, Pfaff SL, Auwerx J, Gage F, Evans RM. Dependence of hippocampal function on ERR?-regulated mitochondrial metabolism. Cell Metab. 2015 Apr 07; 21(4):628-36. PMID: 25863252; PMCID: PMC4393848.
    84. Amador-Arjona A, Cimadamore F, Huang CT, Wright R, Lewis S, Gage F, Terskikh AV. SOX2 primes the epigenetic landscape in neural precursors enabling proper gene activation during hippocampal neurogenesis. Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15):E1936-45. PMID: 25825708; PMCID: PMC4403144.
    85. Schafer ST, Han J, Pena M, von Bohlen Und Halbach O, Peters J, Gage F. The Wnt adaptor protein ATP6AP2 regulates multiple stages of adult hippocampal neurogenesis. J Neurosci. 2015 Mar 25; 35(12):4983-98. PMID: 25810528; PMCID: PMC4389597.
    86. Deng W, Gage F. The effect of immature adult-born dentate granule cells on hyponeophagial behavior is related to their roles in learning and memory. Front Syst Neurosci. 2015; 9:34. PMID: 25798094; PMCID: PMC4351587.
    87. Clemenson GD, Lee SW, Deng W, Barrera VR, Iwamoto KS, Fanselow MS, Gage F. Enrichment rescues contextual discrimination deficit associated with immediate shock. Hippocampus. 2015 Mar; 25(3):385-92. PMID: 25330953; PMCID: PMC4398310.
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    89. Hook V, Brennand KJ, Kim Y, Toneff T, Funkelstein L, Lee KC, Ziegler M, Gage F. Human iPSC neurons display activity-dependent neurotransmitter secretion: aberrant catecholamine levels in schizophrenia neurons. Stem Cell Reports. 2014 Oct 14; 3(4):531-8. PMID: 25358781; PMCID: PMC4223699.
    90. Gage F, Nair P. QnAs with Fred Gage. Proc Natl Acad Sci U S A. 2014 Sep 09; 111(36):12958-9. PMID: 25049423; PMCID: PMC4246929.
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    98. Hashimoto-Torii K, Torii M, Fujimoto M, Nakai A, El Fatimy R, Mezger V, Ju MJ, Ishii S, Chao SH, Brennand KJ, Gage F, Rakic P. Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders. Neuron. 2014 May 07; 82(3):560-72. PMID: 24726381; PMCID: PMC4051437.
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    101. Pao GM, Zhu Q, Perez-Garcia CG, Chou SJ, Suh H, Gage F, O'Leary DD, Verma IM. Role of BRCA1 in brain development. Proc Natl Acad Sci U S A. 2014 Apr 01; 111(13):E1240-8. PMID: 24639535; PMCID: PMC3977248.
    102. Crotti A, Benner C, Kerman BE, Gosselin D, Lagier-Tourenne C, Zuccato C, Cattaneo E, Gage F, Cleveland DW, Glass CK. Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors. Nat Neurosci. 2014 Apr; 17(4):513-21. PMID: 24584051.
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    116. Deshmukh VA, Tardif V, Lyssiotis CA, Green CC, Kerman B, Kim HJ, Padmanabhan K, Swoboda JG, Ahmad I, Kondo T, Gage F, Theofilopoulos AN, Lawson BR, Schultz PG, Lairson LL. A regenerative approach to the treatment of multiple sclerosis. Nature. 2013 Oct 17; 502(7471):327-332. PMID: 24107995; PMCID: PMC4431622.
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    123. Rangel LM, Quinn LK, Chiba AA, Gage F, Aimone JB. A hypothesis for temporal coding of young and mature granule cells. Front Neurosci. 2013; 7:75. PMID: 23717259.
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    128. Liang Y, Franks TM, Marchetto MC, Gage F, Hetzer MW. Dynamic association of NUP98 with the human genome. PLoS Genet. 2013; 9(2):e1003308. PMID: 23468646; PMCID: PMC3585015.
    129. Shimozaki K, Clemenson GD, Gage F. Paired related homeobox protein 1 is a regulator of stemness in adult neural stem/progenitor cells. J Neurosci. 2013 Feb 27; 33(9):4066-75. PMID: 23447615.
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    135. Boyer LF, Campbell B, Larkin S, Mu Y, Gage F. Dopaminergic differentiation of human pluripotent cells. Curr Protoc Stem Cell Biol. 2012 Aug; Chapter 1:Unit1H.6. PMID: 22872424.
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    137. Marchetto MC, Gage F. Modeling brain disease in a dish: really? Cell Stem Cell. 2012 Jun 14; 10(6):642-5. PMID: 22704498.
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    138. Zhao C, Warner-Schmidt J, Duman RS, Gage F. Electroconvulsive seizure promotes spine maturation in newborn dentate granule cells in adult rat. Dev Neurobiol. 2012 Jun; 72(6):937-42. PMID: 21976455; PMCID: PMC3623264.
    139. Yao J, Mu Y, Gage F. Neural stem cells: mechanisms and modeling. Protein Cell. 2012 Apr; 3(4):251-61. PMID: 22549585; PMCID: PMC4875476.
    140. Ge WP, Miyawaki A, Gage F, Jan YN, Jan LY. Local generation of glia is a major astrocyte source in postnatal cortex. Nature. 2012 Mar 28; 484(7394):376-80. PMID: 22456708; PMCID: PMC3777276.
    141. Bracko O, Singer T, Aigner S, Knobloch M, Winner B, Ray J, Clemenson GD, Suh H, Couillard-Despres S, Aigner L, Gage F, Jessberger S. Gene expression profiling of neural stem cells and their neuronal progeny reveals IGF2 as a regulator of adult hippocampal neurogenesis. J Neurosci. 2012 Mar 07; 32(10):3376-87. PMID: 22399759; PMCID: PMC3338187.
    142. Gage F, Muotri AR. What makes each brain unique. Sci Am. 2012 Mar; 306(3):26-31. PMID: 22375319.
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    144. Thuret S, Thallmair M, Horky LL, Gage F. Enhanced functional recovery in MRL/MpJ mice after spinal cord dorsal hemisection. PLoS One. 2012; 7(2):e30904. PMID: 22348029; PMCID: PMC3278405.
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    148. Vivar C, Potter MC, Choi J, Lee JY, Stringer TP, Callaway EM, Gage F, Suh H, van Praag H. Monosynaptic inputs to new neurons in the dentate gyrus. Nat Commun. 2012; 3:1107. PMID: 23033083.
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    151. Boyce VS, Park J, Gage F, Mendell LM. Differential effects of brain-derived neurotrophic factor and neurotrophin-3 on hindlimb function in paraplegic rats. Eur J Neurosci. 2012 Jan; 35(2):221-32. PMID: 22211901; PMCID: PMC3509221.
    152. Shimozaki K, Zhang CL, Suh H, Denli AM, Evans RM, Gage F. SRY-box-containing gene 2 regulation of nuclear receptor tailless (Tlx) transcription in adult neural stem cells. J Biol Chem. 2012 Feb 17; 287(8):5969-78. PMID: 22194602; PMCID: PMC3285364.
    153. Mu Y, Gage F. Adult hippocampal neurogenesis and its role in Alzheimer's disease. Mol Neurodegener. 2011 Dec 22; 6:85. PMID: 22192775; PMCID: PMC3261815.
    154. Coufal NG, Garcia-Perez JL, Peng GE, Marchetto MC, Muotri AR, Mu Y, Carson CT, Macia A, Moran JV, Gage F. Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20382-7. PMID: 22159035; PMCID: PMC3251057.
    155. Brennand KJ, Gage F. Concise review: the promise of human induced pluripotent stem cell-based studies of schizophrenia. Stem Cells. 2011 Dec; 29(12):1915-22. PMID: 22009633; PMCID: PMC3381343.
    156. Lee SW, Clemenson GD, Gage F. New neurons in an aged brain. Behav Brain Res. 2012 Feb 14; 227(2):497-507. PMID: 22024433; PMCID: PMC3264739.
    157. Kuwabara T, Kagalwala MN, Onuma Y, Ito Y, Warashina M, Terashima K, Sanosaka T, Nakashima K, Gage F, Asashima M. Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb. EMBO Mol Med. 2011 Dec; 3(12):742-54. PMID: 21984534; PMCID: PMC3377118.
    158. Brennand KJ, Gage F. Modeling psychiatric disorders through reprogramming. Dis Model Mech. 2012 Jan; 5(1):26-32. PMID: 21954066; PMCID: PMC3255540.
    159. Zhu Q, Pao GM, Huynh AM, Suh H, Tonnu N, Nederlof PM, Gage F, Verma IM. BRCA1 tumour suppression occurs via heterochromatin-mediated silencing. Nature. 2011 Sep 07; 477(7363):179-84. PMID: 21901007; PMCID: PMC3240576.
    160. Marchetto MC, Brennand KJ, Boyer LF, Gage F. Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises. Hum Mol Genet. 2011 Oct 15; 20(R2):R109-15. PMID: 21828073; PMCID: PMC4447776.
    161. Shen B, Xiang Z, Miller B, Louie G, Wang W, Noel JP, Gage F, Wang L. Genetically encoding unnatural amino acids in neural stem cells and optically reporting voltage-sensitive domain changes in differentiated neurons. Stem Cells. 2011 Aug; 29(8):1231-40. PMID: 21681861; PMCID: PMC3209808.
    162. Hester ME, Murtha MJ, Song S, Rao M, Miranda CJ, Meyer K, Tian J, Boulting G, Schaffer DV, Zhu MX, Pfaff SL, Gage F, Kaspar BK. Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes. Mol Ther. 2011 Oct; 19(10):1905-12. PMID: 21772256; PMCID: PMC3188742.
    163. Woods NB, Parker AS, Moraghebi R, Lutz MK, Firth AL, Brennand KJ, Berggren WT, Raya A, Izpisúa Belmonte JC, Gage F, Verma IM. Brief report: efficient generation of hematopoietic precursors and progenitors from human pluripotent stem cell lines. Stem Cells. 2011 Jul; 29(7):1158-64. PMID: 21544903; PMCID: PMC3254148.
    164. Aimone JB, Deng W, Gage F. Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation. Neuron. 2011 May 26; 70(4):589-96. PMID: 21609818; PMCID: PMC3240575.
    165. Brennand KJ, Simone A, Jou J, Gelboin-Burkhart C, Tran N, Sangar S, Li Y, Mu Y, Chen G, Yu D, McCarthy S, Sebat J, Gage F. Modelling schizophrenia using human induced pluripotent stem cells. Nature. 2011 May 12; 473(7346):221-5. PMID: 21490598; PMCID: PMC3392969.
    166. Mu Y, Zhao C, Gage F. Dopaminergic modulation of cortical inputs during maturation of adult-born dentate granule cells. J Neurosci. 2011 Mar 16; 31(11):4113-23. PMID: 21411652; PMCID: PMC3073019.
    167. Yuan SH, Martin J, Elia J, Flippin J, Paramban RI, Hefferan MP, Vidal JG, Mu Y, Killian RL, Israel MA, Emre N, Marsala S, Marsala M, Gage F, Goldstein LS, Carson CT. Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells. PLoS One. 2011 Mar 02; 6(3):e17540. PMID: 21407814; PMCID: PMC3047583.
    168. Aimone JB, Gage F. Modeling new neuron function: a history of using computational neuroscience to study adult neurogenesis. Eur J Neurosci. 2011 Mar; 33(6):1160-9. PMID: 21395860.
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    169. Winner B, Kohl Z, Gage F. Neurodegenerative disease and adult neurogenesis. Eur J Neurosci. 2011 Mar; 33(6):1139-51. PMID: 21395858.
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    170. Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, Pham E, Masliah E, Gage F, Riek R. In vivo demonstration that alpha-synuclein oligomers are toxic. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4194-9. PMID: 21325059; PMCID: PMC3053976.
    171. Kim JE, O'Sullivan ML, Sanchez CA, Hwang M, Israel MA, Brennand K, Deerinck TJ, Goldstein LS, Gage F, Ellisman MH, Ghosh A. Investigating synapse formation and function using human pluripotent stem cell-derived neurons. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):3005-10. PMID: 21278334; PMCID: PMC3041068.
    172. Ruiz S, Brennand K, Panopoulos AD, Herrerías A, Gage F, Izpisua-Belmonte JC. High-efficient generation of induced pluripotent stem cells from human astrocytes. PLoS One. 2010 Dec 09; 5(12):e15526. PMID: 21170306; PMCID: PMC3000364.
    173. Muotri AR, Marchetto MC, Coufal NG, Oefner R, Yeo G, Nakashima K, Gage F. L1 retrotransposition in neurons is modulated by MeCP2. Nature. 2010 Nov 18; 468(7322):443-6. PMID: 21085180; PMCID: PMC3059197.
    174. Meng X, Arocena M, Penninger J, Gage F, Zhao M, Song B. PI3K mediated electrotaxis of embryonic and adult neural progenitor cells in the presence of growth factors. Exp Neurol. 2011 Jan; 227(1):210-7. PMID: 21092738.
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    175. Mathews EA, Morgenstern NA, Piatti VC, Zhao C, Jessberger S, Schinder AF, Gage F. A distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis. J Comp Neurol. 2010 Nov 15; 518(22):4479-90. PMID: 20886617; PMCID: PMC2997649.
    176. Marchetto MC, Carromeu C, Acab A, Yu D, Yeo GW, Mu Y, Chen G, Gage F, Muotri AR. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell. 2010 Nov 12; 143(4):527-39. PMID: 21074045; PMCID: PMC3003590.
    177. Ma DK, Marchetto MC, Guo JU, Ming GL, Gage F, Song H. Epigenetic choreographers of neurogenesis in the adult mammalian brain. Nat Neurosci. 2010 Nov; 13(11):1338-44. PMID: 20975758; PMCID: PMC3324277.
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    179. Petruska JC, Kitay B, Boyce VS, Kaspar BK, Pearse DD, Gage F, Mendell LM. Intramuscular AAV delivery of NT-3 alters synaptic transmission to motoneurons in adult rats. Eur J Neurosci. 2010 Sep; 32(6):997-1005. PMID: 20849530; PMCID: PMC2943849.
    180. Liu D, Ou L, Clemenson GD, Chao C, Lutske ME, Zambetti GP, Gage F, Xu Y. Puma is required for p53-induced depletion of adult stem cells. Nat Cell Biol. 2010 Oct; 12(10):993-8. PMID: 20818388; PMCID: PMC3025300.
    181. Mira H, Andreu Z, Suh H, Lie DC, Jessberger S, Consiglio A, San Emeterio J, Hortigüela R, Marqués-Torrejón MA, Nakashima K, Colak D, Götz M, Fariñas I, Gage F. Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus. Cell Stem Cell. 2010 Jul 02; 7(1):78-89. PMID: 20621052.
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    184. Singer T, McConnell MJ, Marchetto MC, Coufal NG, Gage F. LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes? Trends Neurosci. 2010 Aug; 33(8):345-54. PMID: 20471112; PMCID: PMC2916067.
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    186. Tronel S, Fabre A, Charrier V, Oliet SH, Gage F, Abrous DN. Spatial learning sculpts the dendritic arbor of adult-born hippocampal neurons. Proc Natl Acad Sci U S A. 2010 Apr 27; 107(17):7963-8. PMID: 20375283; PMCID: PMC2867872.
    187. Deng W, Aimone JB, Gage F. New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci. 2010 May; 11(5):339-50. PMID: 20354534; PMCID: PMC2886712.
    188. Glass CK, Saijo K, Winner B, Marchetto MC, Gage F. Mechanisms underlying inflammation in neurodegeneration. Cell. 2010 Mar 19; 140(6):918-34. PMID: 20303880; PMCID: PMC2873093.
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    190. Qu Q, Sun G, Li W, Yang S, Ye P, Zhao C, Yu RT, Gage F, Evans RM, Shi Y. Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal. Nat Cell Biol. 2010 Jan; 12(1):31-40; sup pp 1-9. PMID: 20010817; PMCID: PMC2880892.
    191. Overall RW, Kempermann G, Peirce J, Lu L, Goldowitz D, Gage F, Goodwin S, Smit AB, Airey DC, Rosen GD, Schalkwyk LC, Sutter TR, Nowakowski RS, Whatley S, Williams RW. Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource. Front Neurosci. 2009; 3:55. PMID: 20582282; PMCID: PMC2858614.
    192. Nakashima K, Kohyama J, Namihira M, Gage F, Okano H, Sawamoto K. [Epigenetic mechanisms regulating neural cell fate determination]. No To Hattatsu. 2009 Nov; 41(6):411-4. PMID: 19928537.
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    195. Jessberger S, Gage F, Eisch AJ, Lagace DC. Making a neuron: Cdk5 in embryonic and adult neurogenesis. Trends Neurosci. 2009 Nov; 32(11):575-82. PMID: 19782409; PMCID: PMC2767479.
    196. Marchetto MC, Yeo GW, Kainohana O, Marsala M, Gage F, Muotri AR. Transcriptional signature and memory retention of human-induced pluripotent stem cells. PLoS One. 2009 Sep 18; 4(9):e7076. PMID: 19763270; PMCID: PMC2741600.
    197. Tamaki SJ, Jacobs Y, Dohse M, Capela A, Cooper JD, Reitsma M, He D, Tushinski R, Belichenko PV, Salehi A, Mobley W, Gage F, Huhn S, Tsukamoto AS, Weissman IL, Uchida N. Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis. Cell Stem Cell. 2009 Sep 04; 5(3):310-9. PMID: 19733542.
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    200. Fortun J, Puzis R, Pearse DD, Gage F, Bunge MB. Muscle injection of AAV-NT3 promotes anatomical reorganization of CST axons and improves behavioral outcome following SCI. J Neurotrauma. 2009 Jul; 26(7):941-53. PMID: 19275471.
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    201. Thuret S, Toni N, Aigner S, Yeo GW, Gage F. Hippocampus-dependent learning is associated with adult neurogenesis in MRL/MpJ mice. Hippocampus. 2009 Jul; 19(7):658-69. PMID: 19140178.
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    202. Jagasia R, Steib K, Englberger E, Herold S, Faus-Kessler T, Saxe M, Gage F, Song H, Lie DC. GABA-cAMP response element-binding protein signaling regulates maturation and survival of newly generated neurons in the adult hippocampus. J Neurosci. 2009 Jun 24; 29(25):7966-77. PMID: 19553437; PMCID: PMC2776747.
    203. Andrews MR, Czvitkovich S, Dassie E, Vogelaar CF, Faissner A, Blits B, Gage F, ffrench-Constant C, Fawcett JW. Alpha9 integrin promotes neurite outgrowth on tenascin-C and enhances sensory axon regeneration. J Neurosci. 2009 Apr 29; 29(17):5546-57. PMID: 19403822.
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    204. Saijo K, Winner B, Carson CT, Collier JG, Boyer L, Rosenfeld MG, Gage F, Glass CK. A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell. 2009 Apr 03; 137(1):47-59. PMID: 19345186; PMCID: PMC2754279.
    205. Denli AM, Cao X, Gage F. miR-9 and TLX: chasing tails in neural stem cells. Nat Struct Mol Biol. 2009 Apr; 16(4):346-7. PMID: 19343066.
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    206. Zhao C, Suh H, Gage F. Notch keeps ependymal cells in line. Nat Neurosci. 2009 Mar; 12(3):243-5. PMID: 19238183.
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    207. Jessberger S, Clark RE, Broadbent NJ, Clemenson GD, Consiglio A, Lie DC, Squire LR, Gage F. Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. Learn Mem. 2009 Feb; 16(2):147-54. PMID: 19181621; PMCID: PMC2661246.
    208. Aimone JB, Wiles J, Gage F. Computational influence of adult neurogenesis on memory encoding. Neuron. 2009 Jan 29; 61(2):187-202. PMID: 19186162; PMCID: PMC2670434.
    209. Rose JB, Crews L, Rockenstein E, Adame A, Mante M, Hersh LB, Gage F, Spencer B, Potkar R, Marr RA, Masliah E. Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. J Neurosci. 2009 Jan 28; 29(4):1115-25. PMID: 19176820; PMCID: PMC2768399.
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    211. Jessberger S, Gage F. Fate plasticity of adult hippocampal progenitors: biological relevance and therapeutic use. Trends Pharmacol Sci. 2009 Feb; 30(2):61-5. PMID: 19135265; PMCID: PMC2752320.
    212. Marumoto T, Tashiro A, Friedmann-Morvinski D, Scadeng M, Soda Y, Gage F, Verma IM. Development of a novel mouse glioma model using lentiviral vectors. Nat Med. 2009 Jan; 15(1):110-6. PMID: 19122659; PMCID: PMC2671237.
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    214. Li Y, Mu Y, Gage F. Development of neural circuits in the adult hippocampus. Curr Top Dev Biol. 2009; 87:149-74. PMID: 19427519.
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    216. Marchetto MC, Muotri AR, Mu Y, Smith AM, Cezar GG, Gage F. Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell. 2008 Dec 04; 3(6):649-57. PMID: 19041781.
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    217. Jessberger S, Gage F. Stem-cell-associated structural and functional plasticity in the aging hippocampus. Psychol Aging. 2008 Dec; 23(4):684-91. PMID: 19140640; PMCID: PMC2771615.
    218. Cao X, Pfaff SL, Gage F. YAP regulates neural progenitor cell number via the TEA domain transcription factor. Genes Dev. 2008 Dec 01; 22(23):3320-34. PMID: 19015275; PMCID: PMC2600760.
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    220. Spencer B, Marr RA, Rockenstein E, Crews L, Adame A, Potkar R, Patrick C, Gage F, Verma IM, Masliah E. Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. BMC Neurosci. 2008 Nov 12; 9:109. PMID: 19014502; PMCID: PMC2596170.
    221. Jessberger S, Aigner S, Clemenson GD, Toni N, Lie DC, Karalay O, Overall R, Kempermann G, Gage F. Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus. PLoS Biol. 2008 Nov 11; 6(11):e272. PMID: 18998770.
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    222. Gage F, Selzer ME. Experts provide insights into emerging field of brain and spine repair. Interview by Bridget M. Kuehn. JAMA. 2008 Sep 03; 300(9):1013-4. PMID: 18768407.
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    223. Li X, Barkho BZ, Luo Y, Smrt RD, Santistevan NJ, Liu C, Kuwabara T, Gage F, Zhao X. Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. J Biol Chem. 2008 Oct 10; 283(41):27644-52. PMID: 18689796.
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    227. Zhao C, Deng W, Gage F. Mechanisms and functional implications of adult neurogenesis. Cell. 2008 Feb 22; 132(4):645-60. PMID: 18295581.
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    228. Zhang CL, Zou Y, He W, Gage F, Evans RM. A role for adult TLX-positive neural stem cells in learning and behaviour. Nature. 2008 Feb 21; 451(7181):1004-7. PMID: 18235445.
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    229. Cezar GG, Quam JA, Smith AM, Rosa GJ, Piekarczyk MS, Brown JF, Gage F, Muotri AR. Identification of small molecules from human embryonic stem cells using metabolomics. Stem Cells Dev. 2007 Dec; 16(6):869-82. PMID: 18042039.
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    230. Suh H, Consiglio A, Ray J, Sawai T, D'Amour KA, Gage F. In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. Cell Stem Cell. 2007 Nov; 1(5):515-28. PMID: 18371391; PMCID: PMC2185820.
    231. Muotri AR, Marchetto MC, Coufal NG, Gage F. The necessary junk: new functions for transposable elements. Hum Mol Genet. 2007 Oct 15; 16 Spec No. 2:R159-67. PMID: 17911158.
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    232. Yao W, Nathanson J, Lian I, Gage F, Sung LA. Mouse erythrocyte tropomodulin in the brain reported by lacZ knocked-in downstream from the E1 promoter. Gene Expr Patterns. 2007 Dec; 8(1):36-46. PMID: 17920339.
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    233. Jessberger S, Zhao C, Toni N, Clemenson GD, Li Y, Gage F. Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling. J Neurosci. 2007 Aug 29; 27(35):9400-7. PMID: 17728453.
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    234. Yeo GW, Xu X, Liang TY, Muotri AR, Carson CT, Coufal NG, Gage F. Alternative splicing events identified in human embryonic stem cells and neural progenitors. PLoS Comput Biol. 2007 Oct; 3(10):1951-67. PMID: 17967047; PMCID: PMC2041973.
    235. Lanctot PM, Gage F, Varki AP. The glycans of stem cells. Curr Opin Chem Biol. 2007 Aug; 11(4):373-80. PMID: 17681848; PMCID: PMC2697851.
    236. Aigner S, Denli AM, Gage F. A novel model for an older remodeler: the BAF swap in neurogenesis. Neuron. 2007 Jul 19; 55(2):171-3. PMID: 17640518.
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    237. van Praag H, Lucero MJ, Yeo GW, Stecker K, Heivand N, Zhao C, Yip E, Afanador M, Schroeter H, Hammerstone J, Gage F. Plant-derived flavanol (-)epicatechin enhances angiogenesis and retention of spatial memory in mice. J Neurosci. 2007 May 30; 27(22):5869-78. PMID: 17537957.
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    238. Jessberger S, Nakashima K, Clemenson GD, Mejia E, Mathews E, Ure K, Ogawa S, Sinton CM, Gage F, Hsieh J. Epigenetic modulation of seizure-induced neurogenesis and cognitive decline. J Neurosci. 2007 May 30; 27(22):5967-75. PMID: 17537967.
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    239. Laplagne DA, Kamienkowski JE, Espósito MS, Piatti VC, Zhao C, Gage F, Schinder AF. Similar GABAergic inputs in dentate granule cells born during embryonic and adult neurogenesis. Eur J Neurosci. 2007 May; 25(10):2973-81. PMID: 17509085.
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    240. Toni N, Teng EM, Bushong EA, Aimone JB, Zhao C, Consiglio A, van Praag H, Martone ME, Ellisman MH, Gage F. Synapse formation on neurons born in the adult hippocampus. Nat Neurosci. 2007 Jun; 10(6):727-34. PMID: 17486101.
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    241. Smrt RD, Eaves-Egenes J, Barkho BZ, Santistevan NJ, Zhao C, Aimone JB, Gage F, Zhao X. Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons. Neurobiol Dis. 2007 Jul; 27(1):77-89. PMID: 17532643; PMCID: PMC2789309.
    242. Garcia-Perez JL, Marchetto MC, Muotri AR, Coufal NG, Gage F, O'Shea KS, Moran JV. LINE-1 retrotransposition in human embryonic stem cells. Hum Mol Genet. 2007 Jul 01; 16(13):1569-77. PMID: 17468180.
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    243. El-Amouri SS, Zhu H, Yu J, Gage F, Verma IM, Kindy MS. Neprilysin protects neurons against Abeta peptide toxicity. Brain Res. 2007 Jun 04; 1152:191-200. PMID: 17459354; PMCID: PMC2020816.
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