 Fred Gage
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| Title | Adjunct Professor |
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| Institution | University of California San Diego |
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| Department | Neurosciences |
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| Address | 9500 Gilman Drive #0932
La Jolla CA 92093
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| Phone | 858-453-4100 |
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| vCard | Download vCard |
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 Research Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Sommer A, Maxreiter F, Krach F, Fadler T, Grosch J, Maroni M, Graef D, Eberhardt E, Riemenschneider MJ, Yeo GW, Kohl Z, Xiang W, Gage F, Winkler J, Prots I, Winner B. Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease. Cell Stem Cell. 2018 Jul 05; 23(1):123-131.e6. PMID: 29979986.
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Kim Y, Zheng X, Ansari Z, Bunnell MC, Herdy JR, Traxler L, Lee H, Paquola ACM, Blithikioti C, Ku M, Schlachetzki JCM, Winkler J, Edenhofer F, Glass CK, Paucar AA, Jaeger BN, Pham S, Boyer L, Campbell BC, Hunter T, Mertens J, Gage F. Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile. Cell Rep. 2018 May 29; 23(9):2550-2558. PMID: 29847787.
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Strnadel J, Carromeu C, Bardy C, Navarro M, Platoshyn O, Glud AN, Marsala S, Kafka J, Miyanohara A, Kato T, Tadokoro T, Hefferan MP, Kamizato K, Yoshizumi T, Juhas S, Juhasova J, Ho CS, Kheradmand T, Chen P, Bohaciakova D, Hruska-Plochan M, Todd AJ, Driscoll SP, Glenn TD, Pfaff SL, Klima J, Ciacci J, Curtis E, Gage F, Bui J, Yamada K, Muotri AR, Marsala M. Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs. Sci Transl Med. 2018 May 09; 10(440). PMID: 29743351.
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Sarkar A, Mei A, Paquola ACM, Stern S, Bardy C, Klug JR, Kim S, Neshat N, Kim HJ, Ku M, Shokhirev MN, Adamowicz DH, Marchetto MC, Jappelli R, Erwin JA, Padmanabhan K, Shtrahman M, Jin X, Gage F. Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro. Cell Stem Cell. 2018 May 03; 22(5):684-697.e9. PMID: 29727680.
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Stern S, Linker S, Vadodaria KC, Marchetto MC, Gage F. Prediction of response to drug therapy in psychiatric disorders. Open Biol. 2018 May; 8(5). PMID: 29794033.
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Erwin JA, Paquola ACM, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FIA, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage F. Author Correction: L1-associated genomic regions are deleted in somatic cells of the healthy human brain. Nat Neurosci. 2018 Apr 27. PMID: 29703932.
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Toda T, Parylak SL, Linker SB, Gage F. The role of adult hippocampal neurogenesis in brain health and disease. Mol Psychiatry. 2018 Apr 20. PMID: 29679070.
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Mansour AA, Gonçalves JT, Bloyd CW, Li H, Fernandes S, Quang D, Johnston S, Parylak SL, Jin X, Gage F. An in vivo model of functional and vascularized human brain organoids. Nat Biotechnol. 2018 Jun; 36(5):432-441. PMID: 29658944.
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Bedrosian TA, Quayle C, Novaresi N, Gage F. Early life experience drives structural variation of neural genomes in mice. Science. 2018 03 23; 359(6382):1395-1399. PMID: 29567711.
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Zheng Y, Shen W, Zhang J, Yang B, Liu YN, Qi H, Yu X, Lu SY, Chen Y, Xu YZ, Li Y, Gage F, Mi S, Yao J. Author Correction: CRISPR interference-based specific and efficient gene inactivation in the brain. Nat Neurosci. 2018 Mar 15. PMID: 29545585.
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Zheng Y, Shen W, Zhang J, Yang B, Liu YN, Qi H, Yu X, Lu SY, Chen Y, Xu YZ, Li Y, Gage F, Mi S, Yao J. CRISPR interference-based specific and efficient gene inactivation in the brain. Nat Neurosci. 2018 Mar; 21(3):447-454. PMID: 29403034.
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Vadodaria KC, Amatya DN, Marchetto MC, Gage F. Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward. Genome Med. 2018 Jan 04; 10(1):1. PMID: 29301565.
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Toda T, Gage F. Review: adult neurogenesis contributes to hippocampal plasticity. Cell Tissue Res. 2017 Nov 29. PMID: 29185071.
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Jaeger BN, Parylak SL, Gage F. Mechanisms of dietary flavonoid action in neuronal function and neuroinflammation. Mol Aspects Med. 2017 Nov 09. PMID: 29117513.
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Erwin JA, Paquola ACM, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FIA, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage F. Corrigendum: L1-associated genomic regions are deleted in somatic cells of the healthy human brain. Nat Neurosci. 2017 09 28; 20(10):1427. PMID: 28949329.
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Toda T, Hsu JY, Linker SB, Hu L, Schafer ST, Mertens J, Jacinto FV, Hetzer MW, Gage F. Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells. Cell Stem Cell. 2017 Nov 02; 21(5):618-634.e7. PMID: 28919367.
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Topol A, Zhu S, Hartley BJ, English J, Hauberg ME, Tran N, Rittenhouse CA, Simone A, Ruderfer DM, Johnson J, Readhead B, Hadas Y, Gochman PA, Wang YC, Shah H, Cagney G, Rapoport J, Gage F, Dudley JT, Sklar P, Mattheisen M, Cotter D, Fang G, Brennand KJ. Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells. Cell Rep. 2017 Sep 05; 20(10):2525. PMID: 28877483.
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Vadodaria KC, Stern S, Marchetto MC, Gage F. Serotonin in psychiatry: in vitro disease modeling using patient-derived neurons. Cell Tissue Res. 2018 01; 371(1):161-170. PMID: 28812143.
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Linker SB, Marchetto MC, Narvaiza I, Denli AM, Gage F. Examining non-LTR retrotransposons in the context of the evolving primate brain. BMC Biol. 2017 Aug 11; 15(1):68. PMID: 28800766.
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Newkirk SJ, Lee S, Grandi FC, Gaysinskaya V, Rosser JM, Vanden Berg N, Hogarth CA, Marchetto MCN, Muotri AR, Griswold MD, Ye P, Bortvin A, Gage F, Boeke JD, An W. Intact piRNA pathway prevents L1 mobilization in male meiosis. Proc Natl Acad Sci U S A. 2017 Jul 11; 114(28):E5635-E5644. PMID: 28630288.
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Santos R, Vadodaria KC, Jaeger BN, Mei A, Lefcochilos-Fogelquist S, Mendes APD, Erikson G, Shokhirev M, Randolph-Moore L, Fredlender C, Dave S, Oefner R, Fitzpatrick C, Pena M, Barron JJ, Ku M, Denli AM, Kerman BE, Charnay P, Kelsoe JR, Marchetto MC, Gage F. Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 06 06; 8(6):1757-1769. PMID: 28591655.
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Gosselin D, Skola D, Coufal NG, Holtman IR, Schlachetzki JCM, Sajti E, Jaeger BN, O'Connor C, Fitzpatrick C, Pasillas MP, Pena M, Adair A, Gonda DD, Levy ML, Ransohoff RM, Gage F, Glass CK. An environment-dependent transcriptional network specifies human microglia identity. Science. 2017 06 23; 356(6344). PMID: 28546318.
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Ishii S, Torii M, Son AI, Rajendraprasad M, Morozov YM, Kawasawa YI, Salzberg AC, Fujimoto M, Brennand K, Nakai A, Mezger V, Gage F, Rakic P, Hashimoto-Torii K. Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling. Nat Commun. 2017 May 02; 8:15157. PMID: 28462912.
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Franks TM, Benner C, Narvaiza I, Marchetto MCN, Young JM, Malik HS, Gage F, Hetzer MW. Corrigendum: Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes Dev. 2017 04 15; 31(8):845. PMID: 28512238.
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Lacar B, Linker SB, Jaeger BN, Krishnaswami SR, Barron JJ, Kelder MJ, Parylak SL, Paquola AC, Venepally P, Novotny M, O'Connor C, Fitzpatrick C, Erwin JA, Hsu JY, Husband D, McConnell MJ, Lasken R, Gage F. Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation. Nat Commun. 2017 Mar 17; 8:15047. PMID: 28303884.
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Ramsay L, Marchetto MC, Caron M, Chen SH, Busche S, Kwan T, Pastinen T, Gage F, Bourque G. Conserved expression of transposon-derived non-coding transcripts in primate stem cells. BMC Genomics. 2017 02 28; 18(1):214. PMID: 28245871.
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Kim Y, Santos R, Gage F, Marchetto MC. Molecular Mechanisms of Bipolar Disorder: Progress Made and Future Challenges. Front Cell Neurosci. 2017; 11:30. PMID: 28261061.
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Adamowicz DH, Roy S, Salmon DP, Galasko DR, Hansen LA, Masliah E, Gage F. Hippocampal a-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology. J Neurosci. 2017 Feb 15; 37(7):1675-1684. PMID: 28039370.
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Paquola ACM, Erwin JA, Gage F. Insights into the role of somatic mosaicism in the brain. Curr Opin Syst Biol. 2017 Feb; 1:90-94. PMID: 29226270.
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Han J, Gage F. A role for miR-19 in the migration of adult-born neurons and schizophrenia. Neurogenesis (Austin). 2016; 3(1):e1251873. PMID: 28405585.
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Gonçalves JT, Schafer ST, Gage F. Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior. Cell. 2016 Nov 03; 167(4):897-914. PMID: 27814520.
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Vadodaria KC, Marchetto MC, Mertens J, Gage F. Generating human serotonergic neurons in vitro: Methodological advances. Bioessays. 2016 11; 38(11):1123-1129. PMID: 27716980.
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Erwin JA, Paquola AC, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FI, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage F. L1-associated genomic regions are deleted in somatic cells of the healthy human brain. Nat Neurosci. 2016 12; 19(12):1583-1591. PMID: 27618310.
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Du H, Deng W, Aimone JB, Ge M, Parylak S, Walch K, Zhang W, Cook J, Song H, Wang L, Gage F, Mu Y. Dopaminergic inputs in the dentate gyrus direct the choice of memory encoding. Proc Natl Acad Sci U S A. 2016 09 13; 113(37):E5501-10. PMID: 27573822; PMCID: PMC5027420 [Available on 03/13/17].
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Chailangkarn T, Trujillo CA, Freitas BC, Hrvoj-Mihic B, Herai RH, Yu DX, Brown TT, Marchetto MC, Bardy C, McHenry L, Stefanacci L, Järvinen A, Searcy YM, DeWitt M, Wong W, Lai P, Ard MC, Hanson KL, Romero S, Jacobs B, Dale AM, Dai L, Korenberg JR, Gage F, Bellugi U, Halgren E, Semendeferi K, Muotri AR. A human neurodevelopmental model for Williams syndrome. Nature. 2016 08 18; 536(7616):338-43. PMID: 27509850.
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Nuttle X, Giannuzzi G, Duyzend MH, Schraiber JG, Narvaiza I, Sudmant PH, Penn O, Chiatante G, Malig M, Huddleston J, Benner C, Camponeschi F, Ciofi-Baffoni S, Stessman HA, Marchetto MC, Denman L, Harshman L, Baker C, Raja A, Penewit K, Janke N, Tang WJ, Ventura M, Banci L, Antonacci F, Akey JM, Amemiya CT, Gage F, Reymond A, Eichler EE. Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility. Nature. 2016 08 11; 536(7615):205-9. PMID: 27487209; PMCID: PMC4988886 [Available on 02/11/17].
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van den Hurk M, Kenis G, Bardy C, van den Hove DL, Gage F, Steinbusch HW, Rutten BP. Transcriptional and epigenetic mechanisms of cellular reprogramming to induced pluripotency. Epigenomics. 2016 08; 8(8):1131-49. PMID: 27419933.
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Padmanabhan K, Osakada F, Tarabrina A, Kizer E, Callaway EM, Gage F, Sejnowski TJ. Diverse Representations of Olfactory Information in Centrifugal Feedback Projections. J Neurosci. 2016 07 13; 36(28):7535-45. PMID: 27413162; PMCID: PMC4945671.
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Han J, Kim HJ, Schafer ST, Paquola A, Clemenson GD, Toda T, Oh J, Pankonin AR, Lee BS, Johnston ST, Sarkar A, Denli AM, Gage F. Functional Implications of miR-19 in the Migration of Newborn Neurons in the Adult Brain. Neuron. 2016 07 06; 91(1):79-89. PMID: 27387650.
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Gage F, Guarente LP, Wagers AJ. Aging and Rejuvenation: Insights from Rusty Gage, Leonard Guarente, and Amy Wagers. Trends Mol Med. 2016 08; 22(8):633-634. PMID: 27396512.
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Marchetto MC, Belinson H, Tian Y, Freitas BC, Fu C, Vadodaria K, Beltrao-Braga P, Trujillo CA, Mendes APD, Padmanabhan K, Nunez Y, Ou J, Ghosh H, Wright R, Brennand K, Pierce K, Eichenfield L, Pramparo T, Eyler L, Barnes CC, Courchesne E, Geschwind DH, Gage F, Wynshaw-Boris A, Muotri AR. Altered proliferation and networks in neural cells derived from idiopathic autistic individuals. Mol Psychiatry. 2017 Jun; 22(6):820-835. PMID: 27378147.
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Lacar B, Linker SB, Jaeger BN, Krishnaswami SR, Barron JJ, Kelder MJ, Parylak SL, Paquola AC, Venepally P, Novotny M, O'Connor C, Fitzpatrick C, Erwin JA, Hsu JY, Husband D, McConnell MJ, Lasken R, Gage F. Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation. Nat Commun. 2016 Jun 14; 7:12020. PMID: 27295945; PMCID: PMC4911670.
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Zheng X, Boyer L, Jin M, Mertens J, Kim Y, Ma L, Ma L, Hamm M, Gage F, Hunter T. Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation. Elife. 2016 06 10; 5. PMID: 27282387; PMCID: PMC4963198.
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Bedrosian TA, Linker S, Gage F. Environment-driven somatic mosaicism in brain disorders. Genome Med. 2016 05 23; 8(1):58. PMID: 27215330; PMCID: PMC4877941.
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Mertens J, Marchetto MC, Bardy C, Gage F. Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience. Nat Rev Neurosci. 2016 07; 17(7):424-37. PMID: 27194476.
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Poo MM, Pignatelli M, Ryan TJ, Tonegawa S, Bonhoeffer T, Martin KC, Rudenko A, Tsai LH, Tsien RW, Fishell G, Mullins C, Gonçalves JT, Shtrahman M, Johnston ST, Gage F, Dan Y, Long J, Buzsáki G, Stevens C. What is memory? The present state of the engram. BMC Biol. 2016 05 19; 14:40. PMID: 27197636.
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Franks TM, Benner C, Narvaiza I, Marchetto MC, Young JM, Malik HS, Gage F, Hetzer MW. Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes Dev. 2016 05 15; 30(10):1155-71. PMID: 27198230; PMCID: PMC4888837.
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Oedegaard KJ, Alda M, Anand A, Andreassen OA, Balaraman Y, Berrettini WH, Bhattacharjee A, Brennand KJ, Burdick KE, Calabrese JR, Calkin CV, Claasen A, Coryell WH, Craig D, DeModena A, Frye M, Gage F, Gao K, Garnham J, Gershon E, Jakobsen P, Leckband SG, McCarthy MJ, McInnis MG, Maihofer AX, Mertens J, Morken G, Nievergelt CM, Nurnberger J, Pham S, Schoeyen H, Shekhtman T, Shilling PD, Szelinger S, Tarwater B, Yao J, Zandi PP, Kelsoe JR. The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample. BMC Psychiatry. 2016 May 05; 16:129. PMID: 27150464; PMCID: PMC4857276.
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Gonçalves JT, Bloyd CW, Shtrahman M, Johnston ST, Schafer ST, Parylak SL, Tran T, Chang T, Gage F. In vivo imaging of dendritic pruning in dentate granule cells. Nat Neurosci. 2016 06; 19(6):788-91. PMID: 27135217; PMCID: PMC4941946 [Available on 11/02/16].
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Topol A, Zhu S, Hartley BJ, English J, Hauberg ME, Tran N, Rittenhouse CA, Simone A, Ruderfer DM, Johnson J, Readhead B, Hadas Y, Gochman PA, Wang YC, Shah H, Cagney G, Rapoport J, Gage F, Dudley JT, Sklar P, Mattheisen M, Cotter D, Fang G, Brennand KJ. Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells. Cell Rep. 2016 05 03; 15(5):1024-1036. PMID: 27117414; PMCID: PMC4856588.
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Lacar B, Linker SB, Jaeger BN, Krishnaswami S, Barron J, Kelder M, Parylak S, Paquola A, Venepally P, Novotny M, O'Connor C, Fitzpatrick C, Erwin J, Hsu JY, Husband D, McConnell MJ, Lasken R, Gage F. Nuclear RNA-seq of single neurons reveals molecular signatures of activation. Nat Commun. 2016 Apr 19; 7:11022. PMID: 27090946; PMCID: PMC4838832.
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Harrison BJ, Venkat G, Lamb JL, Hutson TH, Drury C, Rau KK, Bunge MB, Mendell LM, Gage F, Johnson RD, Hill CE, Rouchka EC, Moon LD, Petruska JC. The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity. J Neurosci. 2016 Apr 13; 36(15):4259-75. PMID: 27076424; PMCID: PMC4829650 [Available on 10/13/16].
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Ettle B, Kerman BE, Valera E, Gillmann C, Schlachetzki JC, Reiprich S, Büttner C, Ekici AB, Reis A, Wegner M, Bäuerle T, Riemenschneider MJ, Masliah E, Gage F, Winkler J. a-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy. Acta Neuropathol. 2016 Jul; 132(1):59-75. PMID: 27059609; PMCID: PMC4912450 [Available on 07/01/17].
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Otani T, Marchetto MC, Gage F, Simons BD, Livesey FJ. 2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size. Cell Stem Cell. 2016 Apr 07; 18(4):467-80. PMID: 27049876; PMCID: PMC4826446.
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Zheng X, Boyer L, Jin M, Kim Y, Fan W, Bardy C, Berggren T, Evans RM, Gage F, Hunter T. Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration. Elife. 2016 03 23; 5. PMID: 27008180; PMCID: PMC4846388.
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Mishra HK, Prots I, Havlicek S, Kohl Z, Perez-Branguli F, Boerstler T, Anneser L, Minakaki G, Wend H, Hampl M, Leone M, Brückner M, Klucken J, Reis A, Boyer L, Schuierer G, Behrens J, Lampert A, Engel FB, Gage F, Winkler J, Winner B. GSK3ß-dependent dysregulation of neurodevelopment in SPG11-patient iPSC model. Ann Neurol. 2016 Mar 11. PMID: 26971897.
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Weissman IL, Gage F. A Mechanism for Somatic Brain Mosaicism. Cell. 2016 Feb 11; 164(4):593-5. PMID: 26871622.
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Agre P, Bertozzi C, Bissell M, Campbell KP, Cummings RD, Desai UR, Estes M, Flotte T, Fogleman G, Gage F, Ginsburg D, Gordon JI, Hart G, Hascall V, Kiessling L, Kornfeld S, Lowe J, Magnani J, Mahal LK, Medzhitov R, Roberts RJ, Sackstein R, Sarkar R, Schnaar R, Schwartz N, Varki A, Walt D, Weissman I. Training the next generation of biomedical investigators in glycosciences. J Clin Invest. 2016 Feb; 126(2):405-8. PMID: 26829621; PMCID: PMC4731185 [Available on 02/01/17].
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Tang X, Kim J, Zhou L, Wengert E, Zhang L, Wu Z, Carromeu C, Muotri AR, Marchetto MC, Gage F, Chen G. KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):751-6. PMID: 26733678; PMCID: PMC4725523.
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Sarkar A, Marchetto MC, Gage F. Synaptic activity: An emerging player in schizophrenia. Brain Res. 2017 02 01; 1656:68-75. PMID: 26723567.
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Duricki DA, Hutson TH, Kathe C, Soleman S, Gonzalez-Carter D, Petruska JC, Shine HD, Chen Q, Wood TC, Bernanos M, Cash D, Williams SC, Gage F, Moon LD. Delayed intramuscular human neurotrophin-3 improves recovery in adult and elderly rats after stroke. Brain. 2016 Jan; 139(Pt 1):259-75. PMID: 26614754; PMCID: PMC4785394.
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Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames T, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, Calabrese JR, Oedegaard KJ, McCarthy MJ, Zandi PP, Alda M, Nievergelt CM. Erratum: Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature. 2016 Feb 11; 530(7589):242. PMID: 26605530.
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Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage F, Jaenisch R. Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. Stem Cell Reports. 2015 Dec 08; 5(6):933-945. PMID: 26610635.
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Johnston ST, Shtrahman M, Parylak S, Gonçalves JT, Gage F. Paradox of pattern separation and adult neurogenesis: A dual role for new neurons balancing memory resolution and robustness. Neurobiol Learn Mem. 2016 Mar; 129:60-8. PMID: 26549627; PMCID: PMC4792723 [Available on 03/01/17].
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Kim HJ, Denli AM, Wright R, Baul TD, Clemenson GD, Morcos AS, Zhao C, Schafer ST, Gage F, Kagalwala MN. REST Regulates Non-Cell-Autonomous Neuronal Differentiation and Maturation of Neural Progenitor Cells via Secretogranin II. J Neurosci. 2015 Nov 04; 35(44):14872-84. PMID: 26538656; PMCID: PMC4635134.
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Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames T, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, Calabrese JR, Ødegaard KJ, McCarthy MJ, Zandi PP, Alda M, Alba M, Nievergelt CM. Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature. 2015 Nov 05; 527(7576):95-9. PMID: 26524527; PMCID: PMC4742055.
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Denli AM, Narvaiza I, Kerman BE, Pena M, Benner C, Marchetto MC, Diedrich JK, Aslanian A, Ma J, Moresco JJ, Moore L, Hunter T, Saghatelian A, Gage F. Primate-specific ORF0 contributes to retrotransposon-mediated diversity. Cell. 2015 Oct 22; 163(3):583-93. PMID: 26496605.
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Mu Y, Zhao C, Toni N, Yao J, Gage F. Distinct roles of NMDA receptors at different stages of granule cell development in the adult brain. Elife. 2015 Oct 16; 4:e07871. PMID: 26473971; PMCID: PMC4608052.
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Mertens J, Paquola ACM, Ku M, Hatch E, Böhnke L, Ladjevardi S, McGrath S, Campbell B, Lee H, Herdy JR, Gonçalves JT, Toda T, Kim Y, Winkler J, Yao J, Hetzer MW, Gage F. Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. Cell Stem Cell. 2015 Dec 03; 17(6):705-718. PMID: 26456686.
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Tashiro A, Zhao C, Suh H, Gage F. Purification and Injection of Retroviral Vectors. Cold Spring Harb Protoc. 2015 Oct 01; 2015(10):925-31. PMID: 26430255.
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Tashiro A, Zhao C, Suh H, Gage F. Imaging Newborn Granule Cells in Fixed Sections. Cold Spring Harb Protoc. 2015 Oct 01; 2015(10):932-3. PMID: 26430256.
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Tashiro A, Zhao C, Suh H, Gage F. Analysis of Spine Motility of Newborn Granule Cells in Acute Brain Slices. Cold Spring Harb Protoc. 2015 Oct 01; 2015(10):934-6. PMID: 26430257.
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Tashiro A, Zhao C, Suh H, Gage F. Preparation and Use of Retroviral Vectors for Labeling, Imaging, and Genetically Manipulating Cells. Cold Spring Harb Protoc. 2015 Oct 01; 2015(10):883-8. PMID: 26430260.
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Prescott SL, Srinivasan R, Marchetto MC, Grishina I, Narvaiza I, Selleri L, Gage F, Swigut T, Wysocka J. Enhancer divergence and cis-regulatory evolution in the human and chimp neural crest. Cell. 2015 Sep 24; 163(1):68-83. PMID: 26365491; PMCID: PMC4848043.
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Jovicic A, Mertens J, Boeynaems S, Bogaert E, Chai N, Yamada SB, Paul JW, Sun S, Herdy JR, Bieri G, Kramer NJ, Gage F, Van Den Bosch L, Robberecht W, Gitler AD. Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS. Nat Neurosci. 2015 Sep; 18(9):1226-9. PMID: 26308983; PMCID: PMC4552077.
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Kempermann G, Song H, Gage F. Neurogenesis in the Adult Hippocampus. Cold Spring Harb Perspect Biol. 2015 Sep 01; 7(9):a018812. PMID: 26330519.
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Firth AL, Menon T, Parker GS, Qualls SJ, Lewis BM, Ke E, Dargitz CT, Wright R, Khanna A, Gage F, Verma IM. Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs. Cell Rep. 2015 Sep 01; 12(9):1385-90. PMID: 26299960; PMCID: PMC4559351.
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Han J, Sarkar A, Gage F. MIR137: big impacts from small changes. Nat Neurosci. 2015 Jul; 18(7):931-3. PMID: 26108719.
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Zhao C, Jou J, Wolff LJ, Sun H, Gage F. Spine morphogenesis in newborn granule cells is differentially regulated in the outer and middle molecular layers. J Comp Neurol. 2015 Jul 01; 523(10):1588. PMID: 26109421.
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Kerman BE, Kim HJ, Padmanabhan K, Mei A, Georges S, Joens MS, Fitzpatrick JA, Jappelli R, Chandross KJ, August P, Gage F. In vitro myelin formation using embryonic stem cells. Development. 2015 Jun 15; 142(12):2213-25. PMID: 26015546; PMCID: PMC4483765.
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Adamowicz DH, Mertens J, Gage F. Alzheimer's disease: distinct stages in neurogenic decline? Biol Psychiatry. 2015 Apr 15; 77(8):680-2. PMID: 25835286.
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Bardy C, van den Hurk M, Eames T, Marchand C, Hernandez RV, Kellogg M, Gorris M, Galet B, Palomares V, Brown J, Bang AG, Mertens J, Böhnke L, Boyer L, Simon S, Gage F. Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro. Proc Natl Acad Sci U S A. 2015 May 19; 112(20):E2725-34. PMID: 25870293; PMCID: PMC4443325.
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Pei L, Mu Y, Leblanc M, Alaynick W, Barish GD, Pankratz M, Tseng TW, Kaufman S, Liddle C, Yu RT, Downes M, Pfaff SL, Auwerx J, Gage F, Evans RM. Dependence of hippocampal function on ERR?-regulated mitochondrial metabolism. Cell Metab. 2015 Apr 07; 21(4):628-36. PMID: 25863252; PMCID: PMC4393848.
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Amador-Arjona A, Cimadamore F, Huang CT, Wright R, Lewis S, Gage F, Terskikh AV. SOX2 primes the epigenetic landscape in neural precursors enabling proper gene activation during hippocampal neurogenesis. Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15):E1936-45. PMID: 25825708; PMCID: PMC4403144.
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Schafer ST, Han J, Pena M, von Bohlen Und Halbach O, Peters J, Gage F. The Wnt adaptor protein ATP6AP2 regulates multiple stages of adult hippocampal neurogenesis. J Neurosci. 2015 Mar 25; 35(12):4983-98. PMID: 25810528; PMCID: PMC4389597.
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Deng W, Gage F. The effect of immature adult-born dentate granule cells on hyponeophagial behavior is related to their roles in learning and memory. Front Syst Neurosci. 2015; 9:34. PMID: 25798094; PMCID: PMC4351587.
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Clemenson GD, Lee SW, Deng W, Barrera VR, Iwamoto KS, Fanselow MS, Gage F. Enrichment rescues contextual discrimination deficit associated with immediate shock. Hippocampus. 2015 Mar; 25(3):385-92. PMID: 25330953; PMCID: PMC4398310.
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Aimone JB, Li Y, Lee SW, Clemenson GD, Deng W, Gage F. Regulation and function of adult neurogenesis: from genes to cognition. Physiol Rev. 2014 Oct; 94(4):991-1026. PMID: 25287858; PMCID: PMC4280160.
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Hook V, Brennand KJ, Kim Y, Toneff T, Funkelstein L, Lee KC, Ziegler M, Gage F. Human iPSC neurons display activity-dependent neurotransmitter secretion: aberrant catecholamine levels in schizophrenia neurons. Stem Cell Reports. 2014 Oct 14; 3(4):531-8. PMID: 25358781; PMCID: PMC4223699.
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Gage F, Nair P. QnAs with Fred Gage. Proc Natl Acad Sci U S A. 2014 Sep 09; 111(36):12958-9. PMID: 25049423; PMCID: PMC4246929.
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Erwin JA, Marchetto MC, Gage F. Mobile DNA elements in the generation of diversity and complexity in the brain. Nat Rev Neurosci. 2014 Aug; 15(8):497-506. PMID: 25005482; PMCID: PMC4443810.
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Stein JL, de la Torre-Ubieta L, Tian Y, Parikshak NN, Hernández IA, Marchetto MC, Baker DK, Lu D, Hinman CR, Lowe JK, Wexler EM, Muotri AR, Gage F, Kosik KS, Geschwind DH. A quantitative framework to evaluate modeling of cortical development by neural stem cells. Neuron. 2014 Jul 02; 83(1):69-86. PMID: 24991955; PMCID: PMC4277209.
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Yu DX, Marchetto MC, Gage F. How to make a hippocampal dentate gyrus granule neuron. Development. 2014 Jun; 141(12):2366-75. PMID: 24917496.
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Bekinschtein P, Kent BA, Oomen CA, Clemenson GD, Gage F, Saksida LM, Bussey TJ. Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories. Hippocampus. 2014 Aug; 24(8):905-11. PMID: 24825389; PMCID: PMC4312906.
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Winner B, Marchetto MC, Winkler J, Gage F. Human-induced pluripotent stem cells pave the road for a better understanding of motor neuron disease. Hum Mol Genet. 2014 Sep 15; 23(R1):R27-34. PMID: 24821704.
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Krzisch M, Temprana SG, Mongiat LA, Armida J, Schmutz V, Virtanen MA, Kocher-Braissant J, Kraftsik R, Vutskits L, Conzelmann KK, Bergami M, Gage F, Schinder AF, Toni N. Pre-existing astrocytes form functional perisynaptic processes on neurons generated in the adult hippocampus. Brain Struct Funct. 2015 Jul; 220(4):2027-42. PMID: 24748560; PMCID: PMC4481333.
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Zhao C, Jou J, Wolff LJ, Sun H, Gage F. Spine morphogenesis in newborn granule cells is differentially regulated in the outer and middle molecular layers. J Comp Neurol. 2014 Aug 15; 522(12):2756-66. PMID: 24610721; PMCID: PMC4065223.
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Hashimoto-Torii K, Torii M, Fujimoto M, Nakai A, El Fatimy R, Mezger V, Ju MJ, Ishii S, Chao SH, Brennand KJ, Gage F, Rakic P. Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders. Neuron. 2014 May 07; 82(3):560-72. PMID: 24726381; PMCID: PMC4051437.
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Rockenstein E, Nuber S, Overk CR, Ubhi K, Mante M, Patrick C, Adame A, Trejo-Morales M, Gerez J, Picotti P, Jensen PH, Campioni S, Riek R, Winkler J, Gage F, Winner B, Masliah E. Accumulation of oligomer-prone a-synuclein exacerbates synaptic and neuronal degeneration in vivo. Brain. 2014 May; 137(Pt 5):1496-513. PMID: 24662516; PMCID: PMC3999721.
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Firth AL, Dargitz CT, Qualls SJ, Menon T, Wright R, Singer O, Gage F, Khanna A, Verma IM. Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17):E1723-30. PMID: 24706852; PMCID: PMC4035971.
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Pao GM, Zhu Q, Perez-Garcia CG, Chou SJ, Suh H, Gage F, O'Leary DD, Verma IM. Role of BRCA1 in brain development. Proc Natl Acad Sci U S A. 2014 Apr 01; 111(13):E1240-8. PMID: 24639535; PMCID: PMC3977248.
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Crotti A, Benner C, Kerman BE, Gosselin D, Lagier-Tourenne C, Zuccato C, Cattaneo E, Gage F, Cleveland DW, Glass CK. Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors. Nat Neurosci. 2014 Apr; 17(4):513-21. PMID: 24584051.
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Wright R, Réthelyi JM, Gage F. Enhancing induced pluripotent stem cell models of schizophrenia. JAMA Psychiatry. 2014 Mar; 71(3):334-5. PMID: 24382673.
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Yu DX, Di Giorgio FP, Yao J, Marchetto MC, Brennand K, Wright R, Mei A, McHenry L, Lisuk D, Grasmick JM, Silberman P, Silberman G, Jappelli R, Gage F. Modeling hippocampal neurogenesis using human pluripotent stem cells. Stem Cell Reports. 2014 Mar 11; 2(3):295-310. PMID: 24672753; PMCID: PMC3964286.
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Vadodaria KC, Gage F. SnapShot: adult hippocampal neurogenesis. Cell. 2014 Feb 27; 156(5):1114-1114.e1. PMID: 24581504.
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Lacar B, Parylak SL, Vadodaria KC, Sarkar A, Gage F. Increasing the resolution of the adult neurogenesis picture. F1000Prime Rep. 2014; 6:8. PMID: 24592320; PMCID: PMC3914506.
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Marchetto MC, Gage F. Your brain under the microscope: the promise of stem cells. Cerebrum. 2014 Jan; 2014:1. PMID: 25009691; PMCID: PMC4087191.
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Parylak SL, Deng W, Gage F. Mother's milk programs offspring's cognition. Nat Neurosci. 2014 Jan; 17(1):8-9. PMID: 24369371.
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Havlicek S, Kohl Z, Mishra HK, Prots I, Eberhardt E, Denguir N, Wend H, Plötz S, Boyer L, Marchetto MC, Aigner S, Sticht H, Groemer TW, Hehr U, Lampert A, Schlötzer-Schrehardt U, Winkler J, Gage F, Winner B. Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons. Hum Mol Genet. 2014 May 15; 23(10):2527-41. PMID: 24381312; PMCID: PMC3990156.
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Reilly MT, Faulkner GJ, Dubnau J, Ponomarev I, Gage F. The role of transposable elements in health and diseases of the central nervous system. J Neurosci. 2013 Nov 06; 33(45):17577-86. PMID: 24198348; PMCID: PMC3818539.
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McConnell MJ, Lindberg MR, Brennand KJ, Piper JC, Voet T, Cowing-Zitron C, Shumilina S, Lasken RS, Vermeesch JR, Hall IM, Gage F. Mosaic copy number variation in human neurons. Science. 2013 Nov 01; 342(6158):632-7. PMID: 24179226; PMCID: PMC3975283.
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Gage F, Temple S. Neural stem cells: generating and regenerating the brain. Neuron. 2013 Oct 30; 80(3):588-601. PMID: 24183012.
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Bekinschtein P, Kent BA, Oomen CA, Clemenson GD, Gage F, Saksida LM, Bussey TJ. BDNF in the dentate gyrus is required for consolidation of "pattern-separated" memories. Cell Rep. 2013 Nov 14; 5(3):759-68. PMID: 24209752.
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Marchetto MCN, Narvaiza I, Denli AM, Benner C, Lazzarini TA, Nathanson JL, Paquola ACM, Desai KN, Herai RH, Weitzman MD, Yeo GW, Muotri AR, Gage F. Differential L1 regulation in pluripotent stem cells of humans and apes. Nature. 2013 Nov 28; 503(7477):525-529. PMID: 24153179; PMCID: PMC4064720.
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Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S, Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ, Jones AR, Amaral DG, Šestan N, Gage F, Lein ES. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov; 140(22):4633-44. PMID: 24154525; PMCID: PMC3817946.
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Deshmukh VA, Tardif V, Lyssiotis CA, Green CC, Kerman B, Kim HJ, Padmanabhan K, Swoboda JG, Ahmad I, Kondo T, Gage F, Theofilopoulos AN, Lawson BR, Schultz PG, Lairson LL. A regenerative approach to the treatment of multiple sclerosis. Nature. 2013 Oct 17; 502(7471):327-332. PMID: 24107995; PMCID: PMC4431622.
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Hrvoj-Mihic B, Marchetto MC, Gage F, Semendeferi K, Muotri AR. Novel tools, classic techniques: evolutionary studies using primate pluripotent stem cells. Biol Psychiatry. 2014 Jun 15; 75(12):929-35. PMID: 24041506.
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Sung TC, Chen Z, Thuret S, Vilar M, Gage F, Riek R, Lee KF. P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury. PLoS One. 2013; 8(7):e69286. PMID: 23935974; PMCID: PMC3720591.
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Yu DX, Marchetto MC, Gage F. Therapeutic translation of iPSCs for treating neurological disease. Cell Stem Cell. 2013 Jun 06; 12(6):678-88. PMID: 23746977.
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Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa M, Kawata A, Yoshida M, Nakahata T, Takahashi R, Marchetto MC, Gage F, Yamanaka S, Inoue H. Response to comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells". Sci Transl Med. 2013 Jun 05; 5(188):188lr2. PMID: 23740898.
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Vilchez D, Boyer L, Lutz M, Merkwirth C, Morantte I, Tse C, Spencer B, Page L, Masliah E, Berggren WT, Gage F, Dillin A. FOXO4 is necessary for neural differentiation of human embryonic stem cells. Aging Cell. 2013 Jun; 12(3):518-22. PMID: 23551888; PMCID: PMC4864013.
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Tang X, Zhou L, Wagner AM, Marchetto MC, Muotri AR, Gage F, Chen G. Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells. Stem Cell Res. 2013 Sep; 11(2):743-57. PMID: 23759711; PMCID: PMC3979966.
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Rangel LM, Quinn LK, Chiba AA, Gage F, Aimone JB. A hypothesis for temporal coding of young and mature granule cells. Front Neurosci. 2013; 7:75. PMID: 23717259.
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Li Y, Stam FJ, Aimone JB, Goulding M, Callaway EM, Gage F. Molecular layer perforant path-associated cells contribute to feed-forward inhibition in the adult dentate gyrus. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9106-11. PMID: 23671081; PMCID: PMC3670356.
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Herzog CD, Brown L, Kruegel BR, Wilson A, Tansey MG, Gage F, Johnson EM, Bartus RT. Enhanced neurotrophic distribution, cell signaling and neuroprotection following substantia nigral versus striatal delivery of AAV2-NRTN (CERE-120). Neurobiol Dis. 2013 Oct; 58:38-48. PMID: 23631873.
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Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, Zhang D, Gage F, Ranscht B, Zhang YW, Lipton SA, Hong W, Xu H. Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nat Med. 2013 Apr; 19(4):473-80. PMID: 23524343; PMCID: PMC3911880.
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Deng W, Mayford M, Gage F. Selection of distinct populations of dentate granule cells in response to inputs as a mechanism for pattern separation in mice. Elife. 2013 Mar 20; 2:e00312. PMID: 23538967; PMCID: PMC3602954.
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Liang Y, Franks TM, Marchetto MC, Gage F, Hetzer MW. Dynamic association of NUP98 with the human genome. PLoS Genet. 2013; 9(2):e1003308. PMID: 23468646; PMCID: PMC3585015.
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Shimozaki K, Clemenson GD, Gage F. Paired related homeobox protein 1 is a regulator of stemness in adult neural stem/progenitor cells. J Neurosci. 2013 Feb 27; 33(9):4066-75. PMID: 23447615.
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Kurian L, Sancho-Martinez I, Nivet E, Aguirre A, Moon K, Pendaries C, Volle-Challier C, Bono F, Herbert JM, Pulecio J, Xia Y, Li M, Montserrat N, Ruiz S, Dubova I, Rodriguez C, Denli AM, Boscolo FS, Thiagarajan RD, Gage F, Loring JF, Laurent LC, Izpisua Belmonte JC. Conversion of human fibroblasts to angioblast-like progenitor cells. Nat Methods. 2013 Jan; 10(1):77-83. PMID: 23202434; PMCID: PMC3531579.
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Winner B, Regensburger M, Schreglmann S, Boyer L, Prots I, Rockenstein E, Mante M, Zhao C, Winkler J, Masliah E, Gage F. Role of a-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus. J Neurosci. 2012 Nov 21; 32(47):16906-16. PMID: 23175842; PMCID: PMC4962062.
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Bellin M, Marchetto MC, Gage F, Mummery CL. Induced pluripotent stem cells: the new patient? Nat Rev Mol Cell Biol. 2012 Nov; 13(11):713-26. PMID: 23034453.
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Vilchez D, Boyer L, Morantte I, Lutz M, Merkwirth C, Joyce D, Spencer B, Page L, Masliah E, Berggren WT, Gage F, Dillin A. Increased proteasome activity in human embryonic stem cells is regulated by PSMD11. Nature. 2012 Sep 13; 489(7415):304-8. PMID: 22972301.
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Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa M, Kawata A, Yoshida M, Nakahata T, Takahashi R, Marchetto MC, Gage F, Yamanaka S, Inoue H. Drug screening for ALS using patient-specific induced pluripotent stem cells. Sci Transl Med. 2012 Aug 01; 4(145):145ra104. PMID: 22855461.
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Boyer LF, Campbell B, Larkin S, Mu Y, Gage F. Dopaminergic differentiation of human pluripotent cells. Curr Protoc Stem Cell Biol. 2012 Aug; Chapter 1:Unit1H.6. PMID: 22872424.
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Giorgetti A, Marchetto MC, Li M, Yu D, Fazzina R, Mu Y, Adamo A, Paramonov I, Cardoso JC, Monasterio MB, Bardy C, Cassiani-Ingoni R, Liu GH, Gage F, Izpisua Belmonte JC. Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12556-61. PMID: 22814375; PMCID: PMC3412010.
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Marchetto MC, Gage F. Modeling brain disease in a dish: really? Cell Stem Cell. 2012 Jun 14; 10(6):642-5. PMID: 22704498.
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Zhao C, Warner-Schmidt J, Duman RS, Gage F. Electroconvulsive seizure promotes spine maturation in newborn dentate granule cells in adult rat. Dev Neurobiol. 2012 Jun; 72(6):937-42. PMID: 21976455; PMCID: PMC3623264.
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Yao J, Mu Y, Gage F. Neural stem cells: mechanisms and modeling. Protein Cell. 2012 Apr; 3(4):251-61. PMID: 22549585; PMCID: PMC4875476.
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Ge WP, Miyawaki A, Gage F, Jan YN, Jan LY. Local generation of glia is a major astrocyte source in postnatal cortex. Nature. 2012 Mar 28; 484(7394):376-80. PMID: 22456708; PMCID: PMC3777276.
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Bracko O, Singer T, Aigner S, Knobloch M, Winner B, Ray J, Clemenson GD, Suh H, Couillard-Despres S, Aigner L, Gage F, Jessberger S. Gene expression profiling of neural stem cells and their neuronal progeny reveals IGF2 as a regulator of adult hippocampal neurogenesis. J Neurosci. 2012 Mar 07; 32(10):3376-87. PMID: 22399759; PMCID: PMC3338187.
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Gage F, Muotri AR. What makes each brain unique. Sci Am. 2012 Mar; 306(3):26-31. PMID: 22375319.
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Li Y, Aimone JB, Xu X, Callaway EM, Gage F. Development of GABAergic inputs controls the contribution of maturing neurons to the adult hippocampal network. Proc Natl Acad Sci U S A. 2012 Mar 13; 109(11):4290-5. PMID: 22371596; PMCID: PMC3306704.
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Thuret S, Thallmair M, Horky LL, Gage F. Enhanced functional recovery in MRL/MpJ mice after spinal cord dorsal hemisection. PLoS One. 2012; 7(2):e30904. PMID: 22348029; PMCID: PMC3278405.
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Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage F, Remes AM, Koo EH, Goldstein LS. Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature. 2012 Jan 25; 482(7384):216-20. PMID: 22278060; PMCID: PMC3338985.
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Gage F. ISSCR: beginning the next chapter. Cell Stem Cell. 2012 Jan 06; 10(1):29-31. PMID: 22226353.
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Han J, Denli AM, Gage F. The enemy within: intronic miR-26b represses its host gene, ctdsp2, to regulate neurogenesis. Genes Dev. 2012 Jan 01; 26(1):6-10. PMID: 22215805; PMCID: PMC3258967.
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Vivar C, Potter MC, Choi J, Lee JY, Stringer TP, Callaway EM, Gage F, Suh H, van Praag H. Monosynaptic inputs to new neurons in the dentate gyrus. Nat Commun. 2012; 3:1107. PMID: 23033083.
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Gage F. Transplantation in the future. Prog Brain Res. 2012; 201:7-13. PMID: 23186707.
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Gage F. Transplantation in the future. Prog Brain Res. 2012; 200:7-13. PMID: 23195412.
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Boyce VS, Park J, Gage F, Mendell LM. Differential effects of brain-derived neurotrophic factor and neurotrophin-3 on hindlimb function in paraplegic rats. Eur J Neurosci. 2012 Jan; 35(2):221-32. PMID: 22211901; PMCID: PMC3509221.
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Shimozaki K, Zhang CL, Suh H, Denli AM, Evans RM, Gage F. SRY-box-containing gene 2 regulation of nuclear receptor tailless (Tlx) transcription in adult neural stem cells. J Biol Chem. 2012 Feb 17; 287(8):5969-78. PMID: 22194602; PMCID: PMC3285364.
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Mu Y, Gage F. Adult hippocampal neurogenesis and its role in Alzheimer's disease. Mol Neurodegener. 2011 Dec 22; 6:85. PMID: 22192775; PMCID: PMC3261815.
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Coufal NG, Garcia-Perez JL, Peng GE, Marchetto MC, Muotri AR, Mu Y, Carson CT, Macia A, Moran JV, Gage F. Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20382-7. PMID: 22159035; PMCID: PMC3251057.
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Brennand KJ, Gage F. Concise review: the promise of human induced pluripotent stem cell-based studies of schizophrenia. Stem Cells. 2011 Dec; 29(12):1915-22. PMID: 22009633; PMCID: PMC3381343.
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Lee SW, Clemenson GD, Gage F. New neurons in an aged brain. Behav Brain Res. 2012 Feb 14; 227(2):497-507. PMID: 22024433; PMCID: PMC3264739.
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Kuwabara T, Kagalwala MN, Onuma Y, Ito Y, Warashina M, Terashima K, Sanosaka T, Nakashima K, Gage F, Asashima M. Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb. EMBO Mol Med. 2011 Dec; 3(12):742-54. PMID: 21984534; PMCID: PMC3377118.
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Brennand KJ, Gage F. Modeling psychiatric disorders through reprogramming. Dis Model Mech. 2012 Jan; 5(1):26-32. PMID: 21954066; PMCID: PMC3255540.
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Zhu Q, Pao GM, Huynh AM, Suh H, Tonnu N, Nederlof PM, Gage F, Verma IM. BRCA1 tumour suppression occurs via heterochromatin-mediated silencing. Nature. 2011 Sep 07; 477(7363):179-84. PMID: 21901007; PMCID: PMC3240576.
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Marchetto MC, Brennand KJ, Boyer LF, Gage F. Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises. Hum Mol Genet. 2011 Oct 15; 20(R2):R109-15. PMID: 21828073; PMCID: PMC4447776.
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Shen B, Xiang Z, Miller B, Louie G, Wang W, Noel JP, Gage F, Wang L. Genetically encoding unnatural amino acids in neural stem cells and optically reporting voltage-sensitive domain changes in differentiated neurons. Stem Cells. 2011 Aug; 29(8):1231-40. PMID: 21681861; PMCID: PMC3209808.
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Hester ME, Murtha MJ, Song S, Rao M, Miranda CJ, Meyer K, Tian J, Boulting G, Schaffer DV, Zhu MX, Pfaff SL, Gage F, Kaspar BK. Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes. Mol Ther. 2011 Oct; 19(10):1905-12. PMID: 21772256; PMCID: PMC3188742.
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Woods NB, Parker AS, Moraghebi R, Lutz MK, Firth AL, Brennand KJ, Berggren WT, Raya A, Izpisúa Belmonte JC, Gage F, Verma IM. Brief report: efficient generation of hematopoietic precursors and progenitors from human pluripotent stem cell lines. Stem Cells. 2011 Jul; 29(7):1158-64. PMID: 21544903; PMCID: PMC3254148.
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Aimone JB, Deng W, Gage F. Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation. Neuron. 2011 May 26; 70(4):589-96. PMID: 21609818; PMCID: PMC3240575.
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Brennand KJ, Simone A, Jou J, Gelboin-Burkhart C, Tran N, Sangar S, Li Y, Mu Y, Chen G, Yu D, McCarthy S, Sebat J, Gage F. Modelling schizophrenia using human induced pluripotent stem cells. Nature. 2011 May 12; 473(7346):221-5. PMID: 21490598; PMCID: PMC3392969.
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Mu Y, Zhao C, Gage F. Dopaminergic modulation of cortical inputs during maturation of adult-born dentate granule cells. J Neurosci. 2011 Mar 16; 31(11):4113-23. PMID: 21411652; PMCID: PMC3073019.
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Yuan SH, Martin J, Elia J, Flippin J, Paramban RI, Hefferan MP, Vidal JG, Mu Y, Killian RL, Israel MA, Emre N, Marsala S, Marsala M, Gage F, Goldstein LS, Carson CT. Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells. PLoS One. 2011 Mar 02; 6(3):e17540. PMID: 21407814; PMCID: PMC3047583.
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Aimone JB, Gage F. Modeling new neuron function: a history of using computational neuroscience to study adult neurogenesis. Eur J Neurosci. 2011 Mar; 33(6):1160-9. PMID: 21395860.
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Winner B, Kohl Z, Gage F. Neurodegenerative disease and adult neurogenesis. Eur J Neurosci. 2011 Mar; 33(6):1139-51. PMID: 21395858.
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Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, Pham E, Masliah E, Gage F, Riek R. In vivo demonstration that alpha-synuclein oligomers are toxic. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4194-9. PMID: 21325059; PMCID: PMC3053976.
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Kim JE, O'Sullivan ML, Sanchez CA, Hwang M, Israel MA, Brennand K, Deerinck TJ, Goldstein LS, Gage F, Ellisman MH, Ghosh A. Investigating synapse formation and function using human pluripotent stem cell-derived neurons. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):3005-10. PMID: 21278334; PMCID: PMC3041068.
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Ruiz S, Brennand K, Panopoulos AD, Herrerías A, Gage F, Izpisua-Belmonte JC. High-efficient generation of induced pluripotent stem cells from human astrocytes. PLoS One. 2010 Dec 09; 5(12):e15526. PMID: 21170306; PMCID: PMC3000364.
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Muotri AR, Marchetto MC, Coufal NG, Oefner R, Yeo G, Nakashima K, Gage F. L1 retrotransposition in neurons is modulated by MeCP2. Nature. 2010 Nov 18; 468(7322):443-6. PMID: 21085180; PMCID: PMC3059197.
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Meng X, Arocena M, Penninger J, Gage F, Zhao M, Song B. PI3K mediated electrotaxis of embryonic and adult neural progenitor cells in the presence of growth factors. Exp Neurol. 2011 Jan; 227(1):210-7. PMID: 21092738.
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Mathews EA, Morgenstern NA, Piatti VC, Zhao C, Jessberger S, Schinder AF, Gage F. A distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis. J Comp Neurol. 2010 Nov 15; 518(22):4479-90. PMID: 20886617; PMCID: PMC2997649.
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Marchetto MC, Carromeu C, Acab A, Yu D, Yeo GW, Mu Y, Chen G, Gage F, Muotri AR. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell. 2010 Nov 12; 143(4):527-39. PMID: 21074045; PMCID: PMC3003590.
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Ma DK, Marchetto MC, Guo JU, Ming GL, Gage F, Song H. Epigenetic choreographers of neurogenesis in the adult mammalian brain. Nat Neurosci. 2010 Nov; 13(11):1338-44. PMID: 20975758; PMCID: PMC3324277.
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Aimone JB, Deng W, Gage F. Put them out to pasture? What are old granule cells good for, anyway...? Hippocampus. 2010 Oct; 20(10):1124-5. PMID: 20848611.
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Petruska JC, Kitay B, Boyce VS, Kaspar BK, Pearse DD, Gage F, Mendell LM. Intramuscular AAV delivery of NT-3 alters synaptic transmission to motoneurons in adult rats. Eur J Neurosci. 2010 Sep; 32(6):997-1005. PMID: 20849530; PMCID: PMC2943849.
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Liu D, Ou L, Clemenson GD, Chao C, Lutske ME, Zambetti GP, Gage F, Xu Y. Puma is required for p53-induced depletion of adult stem cells. Nat Cell Biol. 2010 Oct; 12(10):993-8. PMID: 20818388; PMCID: PMC3025300.
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Mira H, Andreu Z, Suh H, Lie DC, Jessberger S, Consiglio A, San Emeterio J, Hortigüela R, Marqués-Torrejón MA, Nakashima K, Colak D, Götz M, Fariñas I, Gage F. Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus. Cell Stem Cell. 2010 Jul 02; 7(1):78-89. PMID: 20621052.
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Mu Y, Lee SW, Gage F. Signaling in adult neurogenesis. Curr Opin Neurobiol. 2010 Aug; 20(4):416-23. PMID: 20471243; PMCID: PMC2942965.
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Aimone JB, Deng W, Gage F. Adult neurogenesis: integrating theories and separating functions. Trends Cogn Sci. 2010 Jul; 14(7):325-37. PMID: 20471301; PMCID: PMC2904863.
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Singer T, McConnell MJ, Marchetto MC, Coufal NG, Gage F. LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes? Trends Neurosci. 2010 Aug; 33(8):345-54. PMID: 20471112; PMCID: PMC2916067.
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Marchetto MC, Winner B, Gage F. Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases. Hum Mol Genet. 2010 Apr 15; 19(R1):R71-6. PMID: 20418487; PMCID: PMC2875052.
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Tronel S, Fabre A, Charrier V, Oliet SH, Gage F, Abrous DN. Spatial learning sculpts the dendritic arbor of adult-born hippocampal neurons. Proc Natl Acad Sci U S A. 2010 Apr 27; 107(17):7963-8. PMID: 20375283; PMCID: PMC2867872.
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Deng W, Aimone JB, Gage F. New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci. 2010 May; 11(5):339-50. PMID: 20354534; PMCID: PMC2886712.
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Glass CK, Saijo K, Winner B, Marchetto MC, Gage F. Mechanisms underlying inflammation in neurodegeneration. Cell. 2010 Mar 19; 140(6):918-34. PMID: 20303880; PMCID: PMC2873093.
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Gage F. Molecular and cellular mechanisms contributing to the regulation, proliferation and differentiation of neural stem cells in the adult dentate gyrus. Keio J Med. 2010; 59(3):79-83. PMID: 20881448.
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Qu Q, Sun G, Li W, Yang S, Ye P, Zhao C, Yu RT, Gage F, Evans RM, Shi Y. Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal. Nat Cell Biol. 2010 Jan; 12(1):31-40; sup pp 1-9. PMID: 20010817; PMCID: PMC2880892.
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Overall RW, Kempermann G, Peirce J, Lu L, Goldowitz D, Gage F, Goodwin S, Smit AB, Airey DC, Rosen GD, Schalkwyk LC, Sutter TR, Nowakowski RS, Whatley S, Williams RW. Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource. Front Neurosci. 2009; 3:55. PMID: 20582282; PMCID: PMC2858614.
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Nakashima K, Kohyama J, Namihira M, Gage F, Okano H, Sawamoto K. [Epigenetic mechanisms regulating neural cell fate determination]. No To Hattatsu. 2009 Nov; 41(6):411-4. PMID: 19928537.
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Deng W, Saxe MD, Gallina IS, Gage F. Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain. J Neurosci. 2009 Oct 28; 29(43):13532-42. PMID: 19864566; PMCID: PMC2787190.
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Muotri AR, Zhao C, Marchetto MC, Gage F. Environmental influence on L1 retrotransposons in the adult hippocampus. Hippocampus. 2009 Oct; 19(10):1002-7. PMID: 19771587; PMCID: PMC2758700.
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Jessberger S, Gage F, Eisch AJ, Lagace DC. Making a neuron: Cdk5 in embryonic and adult neurogenesis. Trends Neurosci. 2009 Nov; 32(11):575-82. PMID: 19782409; PMCID: PMC2767479.
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Marchetto MC, Yeo GW, Kainohana O, Marsala M, Gage F, Muotri AR. Transcriptional signature and memory retention of human-induced pluripotent stem cells. PLoS One. 2009 Sep 18; 4(9):e7076. PMID: 19763270; PMCID: PMC2741600.
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Tamaki SJ, Jacobs Y, Dohse M, Capela A, Cooper JD, Reitsma M, He D, Tushinski R, Belichenko PV, Salehi A, Mobley W, Gage F, Huhn S, Tsukamoto AS, Weissman IL, Uchida N. Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis. Cell Stem Cell. 2009 Sep 04; 5(3):310-9. PMID: 19733542.
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Kuwabara T, Hsieh J, Muotri A, Yeo G, Warashina M, Lie DC, Moore L, Nakashima K, Asashima M, Gage F. Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis. Nat Neurosci. 2009 Sep; 12(9):1097-105. PMID: 19701198; PMCID: PMC2764260.
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Coufal NG, Garcia-Perez JL, Peng GE, Yeo GW, Mu Y, Lovci MT, Morell M, O'Shea KS, Moran JV, Gage F. L1 retrotransposition in human neural progenitor cells. Nature. 2009 Aug 27; 460(7259):1127-31. PMID: 19657334; PMCID: PMC2909034.
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Fortun J, Puzis R, Pearse DD, Gage F, Bunge MB. Muscle injection of AAV-NT3 promotes anatomical reorganization of CST axons and improves behavioral outcome following SCI. J Neurotrauma. 2009 Jul; 26(7):941-53. PMID: 19275471.
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Thuret S, Toni N, Aigner S, Yeo GW, Gage F. Hippocampus-dependent learning is associated with adult neurogenesis in MRL/MpJ mice. Hippocampus. 2009 Jul; 19(7):658-69. PMID: 19140178.
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Jagasia R, Steib K, Englberger E, Herold S, Faus-Kessler T, Saxe M, Gage F, Song H, Lie DC. GABA-cAMP response element-binding protein signaling regulates maturation and survival of newly generated neurons in the adult hippocampus. J Neurosci. 2009 Jun 24; 29(25):7966-77. PMID: 19553437; PMCID: PMC2776747.
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Andrews MR, Czvitkovich S, Dassie E, Vogelaar CF, Faissner A, Blits B, Gage F, ffrench-Constant C, Fawcett JW. Alpha9 integrin promotes neurite outgrowth on tenascin-C and enhances sensory axon regeneration. J Neurosci. 2009 Apr 29; 29(17):5546-57. PMID: 19403822.
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Saijo K, Winner B, Carson CT, Collier JG, Boyer L, Rosenfeld MG, Gage F, Glass CK. A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell. 2009 Apr 03; 137(1):47-59. PMID: 19345186; PMCID: PMC2754279.
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Denli AM, Cao X, Gage F. miR-9 and TLX: chasing tails in neural stem cells. Nat Struct Mol Biol. 2009 Apr; 16(4):346-7. PMID: 19343066.
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Zhao C, Suh H, Gage F. Notch keeps ependymal cells in line. Nat Neurosci. 2009 Mar; 12(3):243-5. PMID: 19238183.
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Jessberger S, Clark RE, Broadbent NJ, Clemenson GD, Consiglio A, Lie DC, Squire LR, Gage F. Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. Learn Mem. 2009 Feb; 16(2):147-54. PMID: 19181621; PMCID: PMC2661246.
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Aimone JB, Wiles J, Gage F. Computational influence of adult neurogenesis on memory encoding. Neuron. 2009 Jan 29; 61(2):187-202. PMID: 19186162; PMCID: PMC2670434.
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Rose JB, Crews L, Rockenstein E, Adame A, Mante M, Hersh LB, Gage F, Spencer B, Potkar R, Marr RA, Masliah E. Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. J Neurosci. 2009 Jan 28; 29(4):1115-25. PMID: 19176820; PMCID: PMC2768399.
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Yeo GW, Coufal NG, Liang TY, Peng GE, Fu XD, Gage F. An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells. Nat Struct Mol Biol. 2009 Feb; 16(2):130-7. PMID: 19136955; PMCID: PMC2735254.
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Jessberger S, Gage F. Fate plasticity of adult hippocampal progenitors: biological relevance and therapeutic use. Trends Pharmacol Sci. 2009 Feb; 30(2):61-5. PMID: 19135265; PMCID: PMC2752320.
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Marumoto T, Tashiro A, Friedmann-Morvinski D, Scadeng M, Soda Y, Gage F, Verma IM. Development of a novel mouse glioma model using lentiviral vectors. Nat Med. 2009 Jan; 15(1):110-6. PMID: 19122659; PMCID: PMC2671237.
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Suh H, Deng W, Gage F. Signaling in adult neurogenesis. Annu Rev Cell Dev Biol. 2009; 25:253-75. PMID: 19575663.
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Li Y, Mu Y, Gage F. Development of neural circuits in the adult hippocampus. Curr Top Dev Biol. 2009; 87:149-74. PMID: 19427519.
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Thompson CL, Pathak SD, Jeromin A, Ng LL, MacPherson CR, Mortrud MT, Cusick A, Riley ZL, Sunkin SM, Bernard A, Puchalski RB, Gage F, Jones AR, Bajic VB, Hawrylycz MJ, Lein ES. Genomic anatomy of the hippocampus. Neuron. 2008 Dec 26; 60(6):1010-21. PMID: 19109908.
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Marchetto MC, Muotri AR, Mu Y, Smith AM, Cezar GG, Gage F. Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell. 2008 Dec 04; 3(6):649-57. PMID: 19041781.
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Jessberger S, Gage F. Stem-cell-associated structural and functional plasticity in the aging hippocampus. Psychol Aging. 2008 Dec; 23(4):684-91. PMID: 19140640; PMCID: PMC2771615.
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Cao X, Pfaff SL, Gage F. YAP regulates neural progenitor cell number via the TEA domain transcription factor. Genes Dev. 2008 Dec 01; 22(23):3320-34. PMID: 19015275; PMCID: PMC2600760.
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Kohyama J, Kojima T, Takatsuka E, Yamashita T, Namiki J, Hsieh J, Gage F, Namihira M, Okano H, Sawamoto K, Nakashima K. Epigenetic regulation of neural cell differentiation plasticity in the adult mammalian brain. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):18012-7. PMID: 19004774; PMCID: PMC2584744.
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Spencer B, Marr RA, Rockenstein E, Crews L, Adame A, Potkar R, Patrick C, Gage F, Verma IM, Masliah E. Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. BMC Neurosci. 2008 Nov 12; 9:109. PMID: 19014502; PMCID: PMC2596170.
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Jessberger S, Aigner S, Clemenson GD, Toni N, Lie DC, Karalay O, Overall R, Kempermann G, Gage F. Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus. PLoS Biol. 2008 Nov 11; 6(11):e272. PMID: 18998770.
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Gage F, Selzer ME. Experts provide insights into emerging field of brain and spine repair. Interview by Bridget M. Kuehn. JAMA. 2008 Sep 03; 300(9):1013-4. PMID: 18768407.
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Li X, Barkho BZ, Luo Y, Smrt RD, Santistevan NJ, Liu C, Kuwabara T, Gage F, Zhao X. Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. J Biol Chem. 2008 Oct 10; 283(41):27644-52. PMID: 18689796.
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Toni N, Laplagne DA, Zhao C, Lombardi G, Ribak CE, Gage F, Schinder AF. Neurons born in the adult dentate gyrus form functional synapses with target cells. Nat Neurosci. 2008 Aug; 11(8):901-7. PMID: 18622400; PMCID: PMC2572641.
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Jessberger S, Toni N, Clemenson GD, Ray J, Gage F. Directed differentiation of hippocampal stem/progenitor cells in the adult brain. Nat Neurosci. 2008 Aug; 11(8):888-93. PMID: 18587391; PMCID: PMC2795354.
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Yeo GW, Coufal N, Aigner S, Winner B, Scolnick JA, Marchetto MC, Muotri AR, Carson C, Gage F. Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic stem cells. Hum Mol Genet. 2008 Apr 15; 17(R1):R67-75. PMID: 18632700.
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Zhao C, Deng W, Gage F. Mechanisms and functional implications of adult neurogenesis. Cell. 2008 Feb 22; 132(4):645-60. PMID: 18295581.
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Zhang CL, Zou Y, He W, Gage F, Evans RM. A role for adult TLX-positive neural stem cells in learning and behaviour. Nature. 2008 Feb 21; 451(7181):1004-7. PMID: 18235445.
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Cezar GG, Quam JA, Smith AM, Rosa GJ, Piekarczyk MS, Brown JF, Gage F, Muotri AR. Identification of small molecules from human embryonic stem cells using metabolomics. Stem Cells Dev. 2007 Dec; 16(6):869-82. PMID: 18042039.
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Suh H, Consiglio A, Ray J, Sawai T, D'Amour KA, Gage F. In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. Cell Stem Cell. 2007 Nov; 1(5):515-28. PMID: 18371391; PMCID: PMC2185820.
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Muotri AR, Marchetto MC, Coufal NG, Gage F. The necessary junk: new functions for transposable elements. Hum Mol Genet. 2007 Oct 15; 16 Spec No. 2:R159-67. PMID: 17911158.
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Yao W, Nathanson J, Lian I, Gage F, Sung LA. Mouse erythrocyte tropomodulin in the brain reported by lacZ knocked-in downstream from the E1 promoter. Gene Expr Patterns. 2007 Dec; 8(1):36-46. PMID: 17920339.
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Jessberger S, Zhao C, Toni N, Clemenson GD, Li Y, Gage F. Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling. J Neurosci. 2007 Aug 29; 27(35):9400-7. PMID: 17728453.
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Yeo GW, Xu X, Liang TY, Muotri AR, Carson CT, Coufal NG, Gage F. Alternative splicing events identified in human embryonic stem cells and neural progenitors. PLoS Comput Biol. 2007 Oct; 3(10):1951-67. PMID: 17967047; PMCID: PMC2041973.
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Lanctot PM, Gage F, Varki AP. The glycans of stem cells. Curr Opin Chem Biol. 2007 Aug; 11(4):373-80. PMID: 17681848; PMCID: PMC2697851.
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Aigner S, Denli AM, Gage F. A novel model for an older remodeler: the BAF swap in neurogenesis. Neuron. 2007 Jul 19; 55(2):171-3. PMID: 17640518.
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van Praag H, Lucero MJ, Yeo GW, Stecker K, Heivand N, Zhao C, Yip E, Afanador M, Schroeter H, Hammerstone J, Gage F. Plant-derived flavanol (-)epicatechin enhances angiogenesis and retention of spatial memory in mice. J Neurosci. 2007 May 30; 27(22):5869-78. PMID: 17537957.
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Jessberger S, Nakashima K, Clemenson GD, Mejia E, Mathews E, Ure K, Ogawa S, Sinton CM, Gage F, Hsieh J. Epigenetic modulation of seizure-induced neurogenesis and cognitive decline. J Neurosci. 2007 May 30; 27(22):5967-75. PMID: 17537967.
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Laplagne DA, Kamienkowski JE, Espósito MS, Piatti VC, Zhao C, Gage F, Schinder AF. Similar GABAergic inputs in dentate granule cells born during embryonic and adult neurogenesis. Eur J Neurosci. 2007 May; 25(10):2973-81. PMID: 17509085.
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Toni N, Teng EM, Bushong EA, Aimone JB, Zhao C, Consiglio A, van Praag H, Martone ME, Ellisman MH, Gage F. Synapse formation on neurons born in the adult hippocampus. Nat Neurosci. 2007 Jun; 10(6):727-34. PMID: 17486101.
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Smrt RD, Eaves-Egenes J, Barkho BZ, Santistevan NJ, Zhao C, Aimone JB, Gage F, Zhao X. Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons. Neurobiol Dis. 2007 Jul; 27(1):77-89. PMID: 17532643; PMCID: PMC2789309.
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Garcia-Perez JL, Marchetto MC, Muotri AR, Coufal NG, Gage F, O'Shea KS, Moran JV. LINE-1 retrotransposition in human embryonic stem cells. Hum Mol Genet. 2007 Jul 01; 16(13):1569-77. PMID: 17468180.
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El-Amouri SS, Zhu H, Yu J, Gage F, Verma IM, Kindy MS. Neprilysin protects neurons against Abeta peptide toxicity. Brain Res. 2007 Jun 04; 1152:191-200. PMID: 17459354; PMCID: PMC2020816.
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Tashiro A, Makino H, Gage F. Experience-specific functional modification of the dentate gyrus through adult neurogenesis: a critical period during an immature stage. J Neurosci. 2007 Mar 21; 27(12):3252-9. PMID: 17376985.
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Pereira AC, Huddleston DE, Brickman AM, Sosunov AA, Hen R, McKhann GM, Sloan R, Gage F, Brown TR, Small SA. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5638-43. PMID: 17374720; PMCID: PMC1838482.
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Cao X, Pfaff SL, Gage F. A functional study of miR-124 in the developing neural tube. Genes Dev. 2007 Mar 01; 21(5):531-6. PMID: 17344415; PMCID: PMC1820895.
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Leingärtner A, Thuret S, Kroll TT, Chou SJ, Leasure JL, Gage F, O'Leary DD. Cortical area size dictates performance at modality-specific behaviors. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):4153-8. PMID: 17360492; PMCID: PMC1820724.
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Suzuki S, Gerhold LM, Böttner M, Rau SW, Dela Cruz C, Yang E, Zhu H, Yu J, Cashion AB, Kindy MS, Merchenthaler I, Gage F, Wise PM. Estradiol enhances neurogenesis following ischemic stroke through estrogen receptors alpha and beta. J Comp Neurol. 2007 Feb 20; 500(6):1064-75. PMID: 17183542.
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Parent JM, Jessberger S, Gage F, Gong C. Is neurogenesis reparative after status epilepticus? Epilepsia. 2007; 48 Suppl 8:69-71. PMID: 18330005.
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Jessberger S, Clemenson GD, Gage F. Spontaneous fusion and nonclonal growth of adult neural stem cells. Stem Cells. 2007 Apr; 25(4):871-4. PMID: 17185607.
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Miller TM, Kim SH, Yamanaka K, Hester M, Umapathi P, Arnson H, Rizo L, Mendell JR, Gage F, Cleveland DW, Kaspar BK. Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51):19546-51. PMID: 17164329; PMCID: PMC1748262.
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Ramirez-Amaya V, Marrone DF, Gage F, Worley PF, Barnes CA. Integration of new neurons into functional neural networks. J Neurosci. 2006 Nov 22; 26(47):12237-41. PMID: 17122048.
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Laplagne DA, Espósito MS, Piatti VC, Morgenstern NA, Zhao C, van Praag H, Gage F, Schinder AF. Functional convergence of neurons generated in the developing and adult hippocampus. PLoS Biol. 2006 Nov; 4(12):e409. PMID: 17121455; PMCID: PMC1637132.
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Carson CT, Aigner S, Gage F. Stem cells: the good, bad and barely in control. Nat Med. 2006 Nov; 12(11):1237-8. PMID: 17088886.
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Suhonen J, Ray J, Blömer U, Gage F, Kaspar B. Ex vivo and in vivo gene delivery to the brain. Curr Protoc Hum Genet. 2006 Nov; Chapter 13:Unit 13.3. PMID: 18428389.
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Horky LL, Galimi F, Gage F, Horner PJ. Fate of endogenous stem/progenitor cells following spinal cord injury. J Comp Neurol. 2006 Oct 01; 498(4):525-38. PMID: 16874803; PMCID: PMC2553041.
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Tashiro A, Sandler VM, Toni N, Zhao C, Gage F. NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus. Nature. 2006 Aug 24; 442(7105):929-33. PMID: 16906136.
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Jagasia R, Song H, Gage F, Lie DC. New regulators in adult neurogenesis and their potential role for repair. Trends Mol Med. 2006 Sep; 12(9):400-5. PMID: 16890023.
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Thuret S, Moon LD, Gage F. Therapeutic interventions after spinal cord injury. Nat Rev Neurosci. 2006 Aug; 7(8):628-43. PMID: 16858391.
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Thallmair M, Ray J, Stallcup WB, Gage F. Functional and morphological effects of NG2 proteoglycan deletion on hippocampal neurogenesis. Exp Neurol. 2006 Nov; 202(1):167-78. PMID: 16814771.
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Muotri AR, Gage F. Generation of neuronal variability and complexity. Nature. 2006 Jun 29; 441(7097):1087-93. PMID: 16810244.
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Suzuki A, Raya Á, Kawakami Y, Morita M, Matsui T, Nakashima K, Gage F, Rodríguez-Esteban C, Izpisúa Belmonte JC. Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10294-10299. PMID: 16801560.
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Aimone JB, Wiles J, Gage F. Potential role for adult neurogenesis in the encoding of time in new memories. Nat Neurosci. 2006 Jun; 9(6):723-7. PMID: 16732202.
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Barkho BZ, Song H, Aimone JB, Smrt RD, Kuwabara T, Nakashima K, Gage F, Zhao X. Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. Stem Cells Dev. 2006 Jun; 15(3):407-21. PMID: 16846377; PMCID: PMC2777811.
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Zhang CL, Zou Y, Yu RT, Gage F, Evans RM. Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1. Genes Dev. 2006 May 15; 20(10):1308-20. PMID: 16702404; PMCID: PMC1472905.
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Suzuki A, Raya A, Kawakami Y, Morita M, Matsui T, Nakashima K, Gage F, Rodríguez-Esteban C, Izpisúa Belmonte JC. Maintenance of embryonic stem cell pluripotency by Nanog-mediated reversal of mesoderm specification. Nat Clin Pract Cardiovasc Med. 2006 Mar; 3 Suppl 1:S114-22. PMID: 16501617.
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Jacobs S, Lie DC, DeCicco KL, Shi Y, DeLuca LM, Gage F, Evans RM. Retinoic acid is required early during adult neurogenesis in the dentate gyrus. Proc Natl Acad Sci U S A. 2006 Mar 07; 103(10):3902-7. PMID: 16505366; PMCID: PMC1450163.
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Yang H, Lu P, McKay HM, Bernot T, Keirstead H, Steward O, Gage F, Edgerton VR, Tuszynski MH. Endogenous neurogenesis replaces oligodendrocytes and astrocytes after primate spinal cord injury. J Neurosci. 2006 Feb 22; 26(8):2157-66. PMID: 16495442.
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Ray J, Gage F. Differential properties of adult rat and mouse brain-derived neural stem/progenitor cells. Mol Cell Neurosci. 2006 Mar; 31(3):560-73. PMID: 16426857.
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Warashina M, Min KH, Kuwabara T, Huynh A, Gage F, Schultz PG, Ding S. A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells. Angew Chem Int Ed Engl. 2006 Jan 16; 45(4):591-3. PMID: 16323231.
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Alisch RS, Garcia-Perez JL, Muotri AR, Gage F, Moran JV. Unconventional translation of mammalian LINE-1 retrotransposons. Genes Dev. 2006 Jan 15; 20(2):210-24. PMID: 16418485; PMCID: PMC1356112.
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Kempermann G, Chesler EJ, Lu L, Williams RW, Gage F. Natural variation and genetic covariance in adult hippocampal neurogenesis. Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3):780-5. PMID: 16407118; PMCID: PMC1325968.
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Zhao C, Teng EM, Summers RG, Ming GL, Gage F. Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus. J Neurosci. 2006 Jan 04; 26(1):3-11. PMID: 16399667.
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Battista D, Ferrari CC, Gage F, Pitossi FJ. Neurogenic niche modulation by activated microglia: transforming growth factor beta increases neurogenesis in the adult dentate gyrus. Eur J Neurosci. 2006 Jan; 23(1):83-93. PMID: 16420418.
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Tashiro A, Zhao C, Gage F. Retrovirus-mediated single-cell gene knockout technique in adult newborn neurons in vivo. Nat Protoc. 2006; 1(6):3049-55. PMID: 17406567.
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Cao X, Yeo G, Muotri AR, Kuwabara T, Gage F. Noncoding RNAs in the mammalian central nervous system. Annu Rev Neurosci. 2006; 29:77-103. PMID: 16776580.
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Borrell V, Kaspar BK, Gage F, Callaway EM. In vivo evidence for radial migration of neurons by long-distance somal translocation in the developing ferret visual cortex. Cereb Cortex. 2006 Nov; 16(11):1571-83. PMID: 16357334.
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Muotri AR, Nakashima K, Toni N, Sandler VM, Gage F. Development of functional human embryonic stem cell-derived neurons in mouse brain. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18644-8. PMID: 16352714; PMCID: PMC1317971.
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Lie DC, Colamarino SA, Song HJ, Désiré L, Mira H, Consiglio A, Lein ES, Jessberger S, Lansford H, Dearie AR, Gage F. Wnt signalling regulates adult hippocampal neurogenesis. Nature. 2005 Oct 27; 437(7063):1370-5. PMID: 16251967.
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Hsieh J, Gage F. Chromatin remodeling in neural development and plasticity. Curr Opin Cell Biol. 2005 Dec; 17(6):664-71. PMID: 16226449.
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Gage F, McAllister AK. Neuronal and glial cell biology. Curr Opin Neurobiol. 2005 Oct; 15(5):497-9. PMID: 16143511.
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Pizzo DP, Coufal NG, Lortie MJ, Gage F, Thal LJ. Regulatable acetylcholine-producing fibroblasts enhance cognitive performance. Mol Ther. 2006 Jan; 13(1):175-82. PMID: 16185935.
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van Praag H, Shubert T, Zhao C, Gage F. Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci. 2005 Sep 21; 25(38):8680-5. PMID: 16177036; PMCID: PMC1360197.
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Cummings BJ, Uchida N, Tamaki SJ, Salazar DL, Hooshmand M, Summers R, Gage F, Anderson AJ. Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):14069-74. PMID: 16172374; PMCID: PMC1216836.
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Singer O, Marr RA, Rockenstein E, Crews L, Coufal NG, Gage F, Verma IM, Masliah E. Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nat Neurosci. 2005 Oct; 8(10):1343-9. PMID: 16136043.
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Genoud S, Maricic I, Kumar V, Gage F. Targeted expression of IGF-1 in the central nervous system fails to protect mice from experimental autoimmune encephalomyelitis. J Neuroimmunol. 2005 Nov; 168(1-2):40-5. PMID: 16120466.
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Aigner S, Gage F. A small gem with great powers: geminin keeps neural progenitors thriving. Dev Cell. 2005 Aug; 9(2):171-2. PMID: 16054024.
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Zupanc GK, Hinsch K, Gage F. Proliferation, migration, neuronal differentiation, and long-term survival of new cells in the adult zebrafish brain. J Comp Neurol. 2005 Aug 01; 488(3):290-319. PMID: 15952170.
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Muotri AR, Chu VT, Marchetto MC, Deng W, Moran JV, Gage F. Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition. Nature. 2005 Jun 16; 435(7044):903-10. PMID: 15959507.
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Lin W, Dominguez B, Yang J, Aryal P, Brandon EP, Gage F, Lee KF. Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism. Neuron. 2005 May 19; 46(4):569-79. PMID: 15944126.
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Miller TM, Kaspar BK, Kops GJ, Yamanaka K, Christian LJ, Gage F, Cleveland DW. Virus-delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis. Ann Neurol. 2005 May; 57(5):773-6. PMID: 15852369; PMCID: PMC1351126.
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Kaspar BK, Frost LM, Christian L, Umapathi P, Gage F. Synergy of insulin-like growth factor-1 and exercise in amyotrophic lateral sclerosis. Ann Neurol. 2005 May; 57(5):649-55. PMID: 15852403.
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Lein ES, Callaway EM, Albright TD, Gage F. Redefining the boundaries of the hippocampal CA2 subfield in the mouse using gene expression and 3-dimensional reconstruction. J Comp Neurol. 2005 Apr 25; 485(1):1-10. PMID: 15776443.
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Scheel JR, Ray J, Gage F, Barlow C. Quantitative analysis of gene expression in living adult neural stem cells by gene trapping. Nat Methods. 2005 May; 2(5):363-70. PMID: 15846364.
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Lilley CE, Carson CT, Muotri AR, Gage F, Weitzman MD. DNA repair proteins affect the lifecycle of herpes simplex virus 1. Proc Natl Acad Sci U S A. 2005 Apr 19; 102(16):5844-9. PMID: 15824307; PMCID: PMC556126.
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Myers CP, Lewcock JW, Hanson MG, Gosgnach S, Aimone JB, Gage F, Lee KF, Landmesser LT, Pfaff SL. Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits. Neuron. 2005 Apr 07; 46(1):37-49. PMID: 15820692.
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Martin MJ, Muotri A, Gage F, Varki A. Human embryonic stem cells express an immunogenic nonhuman sialic acid. Nat Med. 2005 Feb; 11(2):228-32. PMID: 15685172.
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Kuwabara T, Hsieh J, Nakashima K, Warashina M, Taira K, Gage F. The NRSE smRNA specifies the fate of adult hippocampal neural stem cells. Nucleic Acids Symp Ser (Oxf). 2005; (49):87-8. PMID: 17150646.
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Galimi F, Summers RG, van Praag H, Verma IM, Gage F. A role for bone marrow-derived cells in the vasculature of noninjured CNS. Blood. 2005 Mar 15; 105(6):2400-2. PMID: 15572598.
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Hsieh J, Nakashima K, Kuwabara T, Mejia E, Gage F. Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells. Proc Natl Acad Sci U S A. 2004 Nov 23; 101(47):16659-64. PMID: 15537713; PMCID: PMC527137.
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Chin VI, Taupin P, Sanga S, Scheel J, Gage F, Bhatia SN. Microfabricated platform for studying stem cell fates. Biotechnol Bioeng. 2004 Nov 05; 88(3):399-415. PMID: 15486946.
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Consiglio A, Gritti A, Dolcetta D, Follenzi A, Bordignon C, Gage F, Vescovi AL, Naldini L. Robust in vivo gene transfer into adult mammalian neural stem cells by lentiviral vectors. Proc Natl Acad Sci U S A. 2004 Oct 12; 101(41):14835-40. PMID: 15466696; PMCID: PMC522006.
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Hsieh J, Gage F. Epigenetic control of neural stem cell fate. Curr Opin Genet Dev. 2004 Oct; 14(5):461-9. PMID: 15380235.
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Wurmser AE, Nakashima K, Summers RG, Toni N, D'Amour KA, Lie DC, Gage F. Cell fusion-independent differentiation of neural stem cells to the endothelial lineage. Nature. 2004 Jul 15; 430(6997):350-6. PMID: 15254537.
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Pizzo DP, Paban V, Coufal NG, Gage F, Thal LJ. Long-term production of choline acetyltransferase in the CNS after transplantation of fibroblasts modified with a regulatable vector. Brain Res Mol Brain Res. 2004 Jul 05; 126(1):1-13. PMID: 15207910.
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Brandon EP, Mellott T, Pizzo DP, Coufal N, D'Amour KA, Gobeske K, Lortie M, López-Coviella I, Berse B, Thal LJ, Gage F, Blusztajn JK. Choline transporter 1 maintains cholinergic function in choline acetyltransferase haploinsufficiency. J Neurosci. 2004 Jun 16; 24(24):5459-66. PMID: 15201317.
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Gage F. Structural plasticity of the adult brain. Dialogues Clin Neurosci. 2004 Jun; 6(2):135-41. PMID: 22034393; PMCID: PMC3181802.
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Aimone JB, Gage F. Unbiased characterization of high-density oligonucleotide microarrays using probe-level statistics. J Neurosci Methods. 2004 May 30; 135(1-2):27-33. PMID: 15020086.
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Wurmser AE, Palmer TD, Gage F. Neuroscience. Cellular interactions in the stem cell niche. Science. 2004 May 28; 304(5675):1253-5. PMID: 15166350.
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Lein ES, Zhao X, Gage F. Defining a molecular atlas of the hippocampus using DNA microarrays and high-throughput in situ hybridization. J Neurosci. 2004 Apr 14; 24(15):3879-89. PMID: 15084669.
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Kempermann G, Wiskott L, Gage F. Functional significance of adult neurogenesis. Curr Opin Neurobiol. 2004 Apr; 14(2):186-91. PMID: 15082323.
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Markakis EA, Palmer TD, Randolph-Moore L, Rakic P, Gage F. Novel neuronal phenotypes from neural progenitor cells. J Neurosci. 2004 Mar 24; 24(12):2886-97. PMID: 15044527; PMCID: PMC3242437.
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Kuwabara T, Hsieh J, Nakashima K, Taira K, Gage F. A small modulatory dsRNA specifies the fate of adult neural stem cells. Cell. 2004 Mar 19; 116(6):779-93. PMID: 15035981.
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Hsieh J, Aimone JB, Kaspar BK, Kuwabara T, Nakashima K, Gage F. IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes. J Cell Biol. 2004 Jan 05; 164(1):111-22. PMID: 14709544; PMCID: PMC2171962.
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Shi Y, Chichung Lie D, Taupin P, Nakashima K, Ray J, Yu RT, Gage F, Evans RM. Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature. 2004 Jan 01; 427(6969):78-83. PMID: 14702088.
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Marr RA, Guan H, Rockenstein E, Kindy M, Gage F, Verma I, Masliah E, Hersh LB. Neprilysin regulates amyloid Beta peptide levels. J Mol Neurosci. 2004; 22(1-2):5-11. PMID: 14742905.
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Lie DC, Song H, Colamarino SA, Ming GL, Gage F. Neurogenesis in the adult brain: new strategies for central nervous system diseases. Annu Rev Pharmacol Toxicol. 2004; 44:399-421. PMID: 14744252.
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Nakashima K, Colamarino S, Gage F. Embryonic stem cells: staying plastic on plastic. Nat Med. 2004 Jan; 10(1):23-4. PMID: 14702626.
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Schaffer DV, Gage F. Neurogenesis and neuroadaptation. Neuromolecular Med. 2004; 5(1):1-9. PMID: 15001808.
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Muotri AR, Gage F. Vibrating in the background. Nat Genet. 2003 Nov; 35(3):205-7. PMID: 14593403.
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Rhodes JS, van Praag H, Jeffrey S, Girard I, Mitchell GS, Garland T, Gage F. Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running. Behav Neurosci. 2003 Oct; 117(5):1006-16. PMID: 14570550.
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Arvanian VL, Horner PJ, Gage F, Mendell LM. Chronic neurotrophin-3 strengthens synaptic connections to motoneurons in the neonatal rat. J Neurosci. 2003 Sep 24; 23(25):8706-12. PMID: 14507970.
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Gage F. Brain, repair yourself. Sci Am. 2003 Sep; 289(3):46-53. PMID: 12951827.
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Aberg MA, Aberg ND, Palmer TD, Alborn AM, Carlsson-Skwirut C, Bang P, Rosengren LE, Olsson T, Gage F, Eriksson PS. IGF-I has a direct proliferative effect in adult hippocampal progenitor cells. Mol Cell Neurosci. 2003 Sep; 24(1):23-40. PMID: 14550766.
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D'Amour KA, Gage F. Genetic and functional differences between multipotent neural and pluripotent embryonic stem cells. Proc Natl Acad Sci U S A. 2003 Sep 30; 100 Suppl 1:11866-72. PMID: 12923297; PMCID: PMC304100.
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Gage F, Verma IM. Stem cells at the dawn of the 21st century. Proc Natl Acad Sci U S A. 2003 Sep 30; 100 Suppl 1:11817-8. PMID: 12915737; PMCID: PMC304091.
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Kaspar BK, Lladó J, Sherkat N, Rothstein JD, Gage F. Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science. 2003 Aug 08; 301(5634):839-42. PMID: 12907804.
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Dickinson-Anson H, Winkler J, Fisher LJ, Song HJ, Poo Mm, Gage F. Acetylcholine-secreting cells improve age-induced memory deficits. Mol Ther. 2003 Jul; 8(1):51-61. PMID: 12842428.
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South SM, Kohno T, Kaspar BK, Hegarty D, Vissel B, Drake CT, Ohata M, Jenab S, Sailer AW, Malkmus S, Masuyama T, Horner P, Bogulavsky J, Gage F, Yaksh TL, Woolf CJ, Heinemann SF, Inturrisi CE. A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain. J Neurosci. 2003 Jun 15; 23(12):5031-40. PMID: 12832526.
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Scheel JR, Garrett LJ, Allen DM, Carter TA, Randolph-Moore L, Gambello MJ, Gage F, Wynshaw-Boris A, Barlow C. An inbred 129SvEv GFPCre transgenic mouse that deletes loxP-flanked genes in all tissues. Nucleic Acids Res. 2003 May 15; 31(10):e57. PMID: 12736323; PMCID: PMC156060.
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Zhao X, Ueba T, Christie BR, Barkho B, McConnell MJ, Nakashima K, Lein ES, Eadie BD, Willhoite AR, Muotri AR, Summers RG, Chun J, Lee KF, Gage F. Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6777-82. PMID: 12748381; PMCID: PMC164523.
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Brivanlou AH, Gage F, Jaenisch R, Jessell T, Melton D, Rossant J. Stem cells. Setting standards for human embryonic stem cells. Science. 2003 May 09; 300(5621):913-6. PMID: 12738841.
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Klassen HJ, Imfeld KL, Kirov II, Tai L, Gage F, Young MJ, Berman MA. Expression of cytokines by multipotent neural progenitor cells. Cytokine. 2003 May; 22(3-4):101-6. PMID: 12849709.
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Brown J, Cooper-Kuhn CM, Kempermann G, Van Praag H, Winkler J, Gage F, Kuhn HG. Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis. Eur J Neurosci. 2003 May; 17(10):2042-6. PMID: 12786970.
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Klassen H, Imfeld KL, Ray J, Young MJ, Gage F, Berman MA. The immunological properties of adult hippocampal progenitor cells. Vision Res. 2003 Apr; 43(8):947-56. PMID: 12668064.
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Marr RA, Rockenstein E, Mukherjee A, Kindy MS, Hersh LB, Gage F, Verma IM, Masliah E. Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. J Neurosci. 2003 Mar 15; 23(6):1992-6. PMID: 12657655.
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Brandon EP, Lin W, D'Amour KA, Pizzo DP, Dominguez B, Sugiura Y, Thode S, Ko CP, Thal LJ, Gage F, Lee KF. Aberrant patterning of neuromuscular synapses in choline acetyltransferase-deficient mice. J Neurosci. 2003 Jan 15; 23(2):539-49. PMID: 12533614.
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Lai K, Kaspar BK, Gage F, Schaffer DV. Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nat Neurosci. 2003 Jan; 6(1):21-7. PMID: 12469128.
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Kempermann G, Gast D, Kronenberg G, Yamaguchi M, Gage F. Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice. Development. 2003 Jan; 130(2):391-9. PMID: 12466205.
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Taupin P, Gage F. Adult neurogenesis and neural stem cells of the central nervous system in mammals. J Neurosci Res. 2002 Sep 15; 69(6):745-9. PMID: 12205667.
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Tamaki S, Eckert K, He D, Sutton R, Doshe M, Jain G, Tushinski R, Reitsma M, Harris B, Tsukamoto A, Gage F, Weissman I, Uchida N. Engraftment of sorted/expanded human central nervous system stem cells from fetal brain. J Neurosci Res. 2002 Sep 15; 69(6):976-86. PMID: 12205691.
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Lie DC, Dziewczapolski G, Willhoite AR, Kaspar BK, Shults CW, Gage F. The adult substantia nigra contains progenitor cells with neurogenic potential. J Neurosci. 2002 Aug 01; 22(15):6639-49. PMID: 12151543.
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Kempermann G, Gast D, Gage F. Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Ann Neurol. 2002 Aug; 52(2):135-43. PMID: 12210782.
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Horner PJ, Thallmair M, Gage F. Defining the NG2-expressing cell of the adult CNS. J Neurocytol. 2002 Jul-Aug; 31(6-7):469-80. PMID: 14501217.
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Song H, Stevens CF, Gage F. Astroglia induce neurogenesis from adult neural stem cells. Nature. 2002 May 02; 417(6884):39-44. PMID: 11986659.
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Song HJ, Stevens CF, Gage F. Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons. Nat Neurosci. 2002 May; 5(5):438-45. PMID: 11953752.
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Wurmser AE, Gage F. Stem cells: cell fusion causes confusion. Nature. 2002 Apr 04; 416(6880):485-7. PMID: 11932725.
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Kempermann G, Gage F. Genetic influence on phenotypic differentiation in adult hippocampal neurogenesis. Brain Res Dev Brain Res. 2002 Mar 31; 134(1-2):1-12. PMID: 11947932.
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van Praag H, Gage F. Genetics of childhood disorders: XXXVI. Stem cell research, part 1: New neurons in the adult brain. J Am Acad Child Adolesc Psychiatry. 2002 Mar; 41(3):354-6. PMID: 11886031.
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D'Amour KA, Gage F. Are somatic stem cells pluripotent or lineage-restricted? Nat Med. 2002 Mar; 8(3):213-4. PMID: 11875484.
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van Praag H, Schinder AF, Christie BR, Toni N, Palmer TD, Gage F. Functional neurogenesis in the adult hippocampus. Nature. 2002 Feb 28; 415(6875):1030-4. PMID: 11875571.
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Kaspar BK, Vissel B, Bengoechea T, Crone S, Randolph-Moore L, Muller R, Brandon EP, Schaffer D, Verma IM, Lee KF, Heinemann SF, Gage F. Adeno-associated virus effectively mediates conditional gene modification in the brain. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2320-5. PMID: 11842206; PMCID: PMC122363.
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Gage F. Neurogenesis in the adult brain. J Neurosci. 2002 Feb 01; 22(3):612-3. PMID: 11826087.
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Vallières L, Campbell IL, Gage F, Sawchenko PE. Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6. J Neurosci. 2002 Jan 15; 22(2):486-92. PMID: 11784794.
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Kaspar BK, Erickson D, Schaffer D, Hinh L, Gage F, Peterson DA. Targeted retrograde gene delivery for neuronal protection. Mol Ther. 2002 Jan; 5(1):50-6. PMID: 11786045.
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| Year | Publications |
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| 2002 | 16 | | 2003 | 20 | | 2004 | 21 | | 2005 | 22 | | 2006 | 27 | | 2007 | 21 | | 2008 | 14 | | 2009 | 25 | | 2010 | 18 | | 2011 | 21 | | 2012 | 21 | | 2013 | 21 | | 2014 | 22 | | 2015 | 27 | | 2016 | 32 | | 2017 | 15 | | 2018 | 12 |
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