Fred Gage

Title(s)Adjunct Professor, Neurobiology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Neuronal senescence and inflammation in Alzheimer's disease
    NIH RF1AG072502Apr 1, 2021 - Mar 31, 2024
    Role: Principal Investigator
    Combinatorial Actions of Genetic Variants and Gender Bias of Alzherimer's Disease
    NIH R01AG057706Sep 30, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    Dynamics of activity-induced transcription in single dentate granule cells
    NIH R01MH114030Aug 1, 2017 - May 31, 2022
    Role: Principal Investigator
    Assessing cellular aging in old and rejuvenated neurons from Alzheimer patients
    NIH R01AG056306Jul 15, 2017 - Apr 30, 2022
    Role: Principal Investigator
    iPSC-based platform development for major psychiatric disorder modeling and discovery
    NIH U19MH106434Aug 17, 2016 - May 31, 2021
    Role: Co-Principal Investigator
    3/3-Schizophrenia Genetics and Brain Somatic Mosaicism
    NIH U01MH106882Apr 20, 2015 - Jul 31, 2020
    Role: Principal Investigator
    Exploring Human-Induced Pluripotent Stem Cells for Alzheimer's Disease Research
    NIH RF1AG042985Sep 1, 2012 - Aug 31, 2014
    Role: Co-Principal Investigator
    Development and Analysis of hiPSCs for Studies on Addiction
    NIH R21DA032986Sep 30, 2011 - Jul 31, 2014
    Role: Co-Principal Investigator
    Single-Cell Approaches to Reveal How Jumping Genes Individualize Neural Circuits
    NIH R01MH095741Sep 20, 2011 - Jun 30, 2016
    Role: Principal Investigator
    DISTINCTIVE SPATIOTEMPORAL MAP OF TARGET ACTIVATION BY YOUNG NEURONS OF THE ADULT
    NIH R03TW008607Jan 1, 2011 - Jun 30, 2015
    Role: Co-Principal Investigator
    Functional Analysis of Adult Hippocampal Neurogenesis
    NIH R01MH090258Apr 2, 2010 - Jan 31, 2015
    Role: Principal Investigator
    L1 Retrotransposon and Neural Diversity
    NIH R01MH088485Aug 12, 2009 - Oct 30, 2013
    Role: Principal Investigator
    The Role of MeCP2 in L1 Neuronal Retrotransposition
    NIH R56MH082070Sep 30, 2008 - Sep 29, 2009
    Role: Principal Investigator
    Translational Research of AAV-IGF-1 Gene Therapy for ALS
    NIH U01NS048925Sep 15, 2005 - Feb 28, 2009
    Role: Principal Investigator
    Role of Astrocyte-Derived Wnts in Adult Neurogenesis
    NIH R01NS050217May 18, 2005 - Apr 30, 2010
    Role: Principal Investigator
    smRNA-Mediated Regulation of Adult Neural Stem Cell Fate
    NIH R01NS052842May 18, 2005 - Apr 30, 2009
    Role: Principal Investigator
    Neurophysiology of Adult Substantia Nigra Stem Cells
    NIH R03TW006130Jan 1, 2003 - Dec 31, 2005
    Role: Principal Investigator
    Gene Targeting and Regulation for Neurological Disease
    NIH R01AG021876Aug 15, 2002 - Jul 31, 2007
    Role: Principal Investigator
    Function of Stem Cell-Derived Neurons in the Aging Brain
    NIH R01AG020938Apr 1, 2002 - Mar 31, 2008
    Role: Principal Investigator
    Conference on Stem Cells: Origins, Fate and Functions
    NIH R13NS042933Jan 1, 2002 - Dec 31, 2002
    Role: Principal Investigator
    THERAPEUTIC POTENTIALS OF CNS STEM CELLS
    NIH R13NS039557Jul 1, 1999 - Jun 30, 2000
    Role: Principal Investigator
    NEURONAL PRECURSOR CELLS FOR TRANSPLANT AFTER CNS TRAUMA
    NIH/NINDS N01NS062348Sep 30, 1996 - Sep 29, 2002
    Role: Principal Investigator
    NEURONAL PRECURSOR CELLS FOR TRANSPLANTATION AFTER CNS
    NIH/NINDS N01NS062349Sep 30, 1996 - Sep 29, 2002
    Role: Co-Principal Investigator
    Training in the Neuroplasticity of Aging
    NIH T32AG000216Sep 30, 1992 - Apr 30, 2018
    Role: Co-Principal Investigator
    Gene Therapy for Alzheimer's Disease
    NIH P01AG010435Sep 30, 1991 - Mar 31, 2016
    Role: Co-Principal Investigator
    Cell Genesis in the Intact and Injured Substantia Nigra
    NIH R01AG008514Jul 1, 1989 - Jun 30, 2006
    Role: Principal Investigator
    GRAFTING GENETICALLY MODIFIED CELLS TO THE BRAIN
    NIH R37AG008514Jul 1, 1989 - Jun 30, 2001
    Role: Principal Investigator
    CHARACTERIZATION &UTILIZATION OF ADULT PROGENITOR CELLS
    NIH R01AG006088Jul 1, 1985 - Feb 28, 2002
    Role: Principal Investigator
    EMBRYONIC NERVE CELL TRANSPLANTATION IN BRAINS OF AGED
    NIH R01AG003766Apr 1, 1983 - Jun 30, 1985
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Morphological diversification and functional maturation of human astrocytes in glia-enriched cortical organoid transplanted in mouse brain. Nat Biotechnol. 2024 Feb 28. Wang M, Zhang L, Novak SW, Yu J, Gallina IS, Xu LL, Lim CK, Fernandes S, Shokhirev MN, Williams AE, Saxena MD, Coorapati S, Parylak SL, Quintero C, Molina E, Andrade LR, Manor U, Gage FH. PMID: 38418648.
      View in: PubMed   Mentions:    Fields:    
    2. Synaptic dysfunction and extracellular matrix dysregulation in dopaminergic neurons from sporadic and E326K-GBA1 Parkinson's disease patients. NPJ Parkinsons Dis. 2024 Feb 19; 10(1):38. Rosh I, Tripathi U, Hussein Y, Rike WA, Djamus J, Shklyar B, Manole A, Houlden H, Winkler J, Gage FH, Stern S. PMID: 38374278; PMCID: PMC10876637.
      View in: PubMed   Mentions:
    3. Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation. Cell Rep. 2024 Feb 12; 43(2):113774. Toda T, Bedrosian TA, Schafer ST, Cuoco MS, Linker SB, Ghassemzadeh S, Mitchell L, Whiteley JT, Novaresi N, McDonald AH, Gallina IS, Yoon H, Hester ME, Pena M, Lim C, Suljic E, AlFatah Mansour A, Boulard M, Parylak SL, Gage FH. PMID: 38349791.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Tyro3 promotes the maturation of glutamatergic synapses. Front Neurosci. 2024; 18:1327423. Miao S, Fourgeaud L, Burrola PG, Stern S, Zhang Y, Happonen KE, Novak SW, Gage FH, Lemke G. PMID: 38410160; PMCID: PMC10894971.
      View in: PubMed   Mentions: 1  
    5. Human iN neuronal model of schizophrenia displays dysregulation of chromogranin B and related neuropeptide transmitter signatures. Mol Psychiatry. 2024 Feb 02. Podvin S, Jones J, Kang A, Goodman R, Reed P, Lietz CB, Then J, Lee KC, Eyler LT, Jeste DV, Gage FH, Hook V. PMID: 38302561.
      View in: PubMed   Mentions:    Fields:    
    6. NGLY1 mutations cause protein aggregation in human neurons. Cell Rep. 2023 12 26; 42(12):113466. Manole A, Wong T, Rhee A, Novak S, Chin SM, Tsimring K, Paucar A, Williams A, Newmeyer TF, Schafer ST, Rosh I, Kaushik S, Hoffman R, Chen S, Wang G, Snyder M, Cuervo AM, Andrade L, Manor U, Lee K, Jones JR, Stern S, Marchetto MC, Gage FH. PMID: 38039131; PMCID: PMC10826878.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases. Sci Data. 2023 11 20; 10(1):813. Garrison MA, Jang Y, Bae T, Cherskov A, Emery SB, Fasching L, Jones A, Moldovan JB, Molitor C, Pochareddy S, Peters MA, Shin JH, Wang Y, Yang X, Akbarian S, Chess A, Gage FH, Gleeson JG, Kidd JM, McConnell M, Mills RE, Moran JV, Park PJ, Sestan N, Urban AE, Vaccarino FM, Walsh CA, Weinberger DR, Wheelan SJ, Abyzov A, BSMN Consortium. PMID: 37985666; PMCID: PMC10662356.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Immunoglobulin genes expressed in lymphoblastoid cell lines discern and predict lithium response in bipolar disorder patients. Mol Psychiatry. 2023 Oct; 28(10):4280-4293. Mizrahi L, Choudhary A, Ofer P, Goldberg G, Milanesi E, Kelsoe JR, Gurwitz D, Alda M, Gage FH, Stern S. PMID: 37488168; PMCID: PMC10827667.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Neural cell state shifts and fate loss in ageing and age-related diseases. Nat Rev Neurol. 2023 07; 19(7):434-443. Traxler L, Lucciola R, Herdy JR, Jones JR, Mertens J, Gage FH. PMID: 37268723; PMCID: PMC10478103.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. An in vivo neuroimmune organoid model to study human microglia phenotypes. Cell. 2023 05 11; 186(10):2111-2126.e20. Schafer ST, Mansour AA, Schlachetzki JCM, Pena M, Ghassemzadeh S, Mitchell L, Mar A, Quang D, Stumpf S, Ortiz IS, Lana AJ, Baek C, Zaghal R, Glass CK, Nimmerjahn A, Gage FH. PMID: 37172564; PMCID: PMC10284271.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    11. Novel correlative analysis identifies multiple genomic variations impacting ASD with macrocephaly. Hum Mol Genet. 2023 05 05; 32(10):1589-1606. Fu C, Ngo J, Zhang S, Lu L, Miron A, Schafer S, Gage FH, Jin F, Schumacher FR, Wynshaw-Boris A. PMID: 36519762; PMCID: PMC10162433.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Contributions of circadian clock genes to cell survival in fibroblast models of lithium-responsive bipolar disorder. Eur Neuropsychopharmacol. 2023 09; 74:1-14. Mishra HK, Wei H, Rohr KE, Ko I, Nievergelt CM, Maihofer AX, Shilling PD, Alda M, Berrettini WH, Brennand KJ, Calabrese JR, Coryell WH, Frye M, Gage F, Gershon E, McInnis MG, Nurnberger J, Oedegaard KJ, Zandi PP, Kelsoe JR, McCarthy MJ. PMID: 37126998.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    13. Neural Organoids and the Quest to Understand and Treat Psychiatric Disease. Biol Psychiatry. 2023 04 01; 93(7):588-589. Arlotta P, Gage FH. PMID: 36889858.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis. Mol Psychiatry. 2023 Mar 29. Niemsiri V, Rosenthal SB, Nievergelt CM, Maihofer AX, Marchetto MC, Santos R, Shekhtman T, Alliey-Rodriguez N, Anand A, Balaraman Y, Berrettini WH, Bertram H, Burdick KE, Calabrese JR, Calkin CV, Conroy C, Coryell WH, DeModena A, Eyler LT, Feeder S, Fisher C, Frazier N, Frye MA, Gao K, Garnham J, Gershon ES, Goes FS, Goto T, Harrington GJ, Jakobsen P, Kamali M, Kelly M, Leckband SG, Lohoff FW, McCarthy MJ, McInnis MG, Craig D, Millett CE, Mondimore F, Morken G, Nurnberger JI, Donovan CO, Øedegaard KJ, Ryan K, Schinagle M, Shilling PD, Slaney C, Stapp EK, Stautland A, Tarwater B, Zandi PP, Alda M, Fisch KM, Gage FH, Kelsoe JR. PMID: 36991131.
      View in: PubMed   Mentions: 5     Fields:    
    15. Adult neurogenesis in the hippocampus. Hippocampus. 2023 04; 33(4):269-270. Kempermann G, Song H, Gage FH. PMID: 36912499.
      View in: PubMed   Mentions:    Fields:    
    16. Neuronal activity-related transcription is blunted in immature compared to mature dentate granule cells. Hippocampus. 2023 04; 33(4):412-423. Parylak SL, Qiu F, Linker SB, Gallina IS, Lim CK, Preciado D, McDonald AH, Zhou X, Gage FH. PMID: 36811254.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    17. BCI-838, an orally active mGluR2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the PS19 MAPTP301S mouse model of tauopathy. Neurosci Lett. 2023 02 16; 797:137080. Perez-Garcia G, Bicak M, Haure-Mirande JV, Perez GM, Otero-Pagan A, Gama Sosa MA, De Gasperi R, Sano M, Barlow C, Gage FH, Readhead B, Ehrlich ME, Gandy S, Elder GA. PMID: 36657633; PMCID: PMC9974759.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    18. Transplantation Strategies to Enhance Maturity and Cellular Complexity in Brain Organoids. Biol Psychiatry. 2023 04 01; 93(7):616-621. Wang M, Gage FH, Schafer ST. PMID: 36739209; PMCID: PMC10662460.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    19. Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex. Nat Commun. 2022 12 26; 13(1):7945. Wilson MN, Thunemann M, Liu X, Lu Y, Puppo F, Adams JW, Kim JH, Ramezani M, Pizzo DP, Djurovic S, Andreassen OA, Mansour AA, Gage FH, Muotri AR, Devor A, Kuzum D. PMID: 36572698; PMCID: PMC9792589.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    20. Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer's disease. Cell Stem Cell. 2022 12 01; 29(12):1637-1652.e6. Herdy JR, Traxler L, Agarwal RK, Karbacher L, Schlachetzki JCM, Boehnke L, Zangwill D, Galasko D, Glass CK, Mertens J, Gage FH. PMID: 36459967; PMCID: PMC10093780.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    21. Druggable transcriptomic pathways revealed in Parkinson's patient-derived midbrain neurons. NPJ Parkinsons Dis. 2022 Oct 18; 8(1):134. van den Hurk M, Lau S, Marchetto MC, Mertens J, Stern S, Corti O, Brice A, Winner B, Winkler J, Gage FH, Bardy C. PMID: 36258029; PMCID: PMC9579158.
      View in: PubMed   Mentions: 3  
    22. Human-specific regulation of neural maturation identified by cross-primate transcriptomics. Curr Biol. 2022 Nov 21; 32(22):4797-4807.e5. Linker SB, Narvaiza I, Hsu JY, Wang M, Qiu F, Mendes APD, Oefner R, Kottilil K, Sharma A, Randolph-Moore L, Mejia E, Santos R, Marchetto MC, Gage FH. PMID: 36228612.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    23. A nomenclature consensus for nervous system organoids and assembloids. Nature. 2022 09; 609(7929):907-910. Pa?ca SP, Arlotta P, Bateup HS, Camp JG, Cappello S, Gage FH, Knoblich JA, Kriegstein AR, Lancaster MA, Ming GL, Muotri AR, Park IH, Reiner O, Song H, Studer L, Temple S, Testa G, Treutlein B, Vaccarino FM. PMID: 36171373; PMCID: PMC10571504.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    24. Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer's disease. Cell Metab. 2022 09 06; 34(9):1248-1263.e6. Traxler L, Herdy JR, Stefanoni D, Eichhorner S, Pelucchi S, Szücs A, Santagostino A, Kim Y, Agarwal RK, Schlachetzki JCM, Glass CK, Lagerwall J, Galasko D, Gage FH, D'Alessandro A, Mertens J. PMID: 35987203; PMCID: PMC9458870.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    25. Reduced synaptic activity and dysregulated extracellular matrix pathways in midbrain neurons from Parkinson's disease patients. NPJ Parkinsons Dis. 2022 Aug 10; 8(1):103. Stern S, Lau S, Manole A, Rosh I, Percia MM, Ben Ezer R, Shokhirev MN, Qiu F, Schafer S, Mansour AA, Mangan KP, Stern T, Ofer P, Stern Y, Diniz Mendes AP, Djamus J, Moore LR, Nayak R, Laufer SH, Aicher A, Rhee A, Wong TL, Nguyen T, Linker SB, Winner B, Freitas BC, Jones E, Sagi I, Bardy C, Brice A, Winkler J, Marchetto MC, Gage FH. PMID: 35948563; PMCID: PMC9365794.
      View in: PubMed   Mentions: 8  
    26. Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability. Science. 2022 07 29; 377(6605):511-517. Bae T, Fasching L, Wang Y, Shin JH, Suvakov M, Jang Y, Norton S, Dias C, Mariani J, Jourdon A, Wu F, Panda A, Pattni R, Chahine Y, Yeh R, Roberts RC, Huttner A, Kleinman JE, Hyde TM, Straub RE, Walsh CA, Brain Somatic Mosaicism Network§, Urban AE, Leckman JF, Weinberger DR, Vaccarino FM, Abyzov A. PMID: 35901164; PMCID: PMC9420557.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    27. Methods for culturing adult CNS neurons reveal a CNS conditioning effect. Cell Rep Methods. 2022 07 18; 2(7):100255. van Niekerk EA, Kawaguchi R, Marques de Freria C, Groeniger K, Marchetto MC, Dupraz S, Bradke F, Geschwind DH, Gage FH, Tuszynski MH. PMID: 35880023; PMCID: PMC9308166.
      View in: PubMed   Mentions: 3  Translation:HumansCells
    28. Dynamic Interrogation of Stochastic Transcriptome Trajectories Using Disease Associated Genes Reveals Distinct Origins of Neurological and Psychiatric Disorders. Front Neurosci. 2022; 16:884707. Bermperidis T, Schafer S, Gage FH, Sejnowski T, Torres EB. PMID: 35720720; PMCID: PMC9201694.
      View in: PubMed   Mentions:
    29. Oleic acid regulates hippocampal neurogenesis as a TLX ligand. Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2203038119. Shi Y, Evans RM, Gage FH. PMID: 35344400; PMCID: PMC9169763.
      View in: PubMed   Mentions: 1     Fields:    
    30. Chronic cortisol differentially impacts stem cell-derived astrocytes from major depressive disorder patients. Transl Psychiatry. 2021 11 30; 11(1):608. Heard KJ, Shokhirev MN, Becronis C, Fredlender C, Zahid N, Le AT, Ji Y, Skime M, Nelson T, Hall-Flavin D, Weinshilboum R, Gage FH, Vadodaria KC. PMID: 34848679; PMCID: PMC8632962.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    31. Adult neurogenesis in neurological diseases. Science. 2021 Nov 26; 374(6571):1049-1050. Gage FH. PMID: 34822282.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    32. The San Diego Nathan Shock Center: tackling the heterogeneity of aging. Geroscience. 2021 10; 43(5):2139-2148. Shadel GS, Adams PD, Berggren WT, Diedrich JK, Diffenderfer KE, Gage FH, Hah N, Hansen M, Hetzer MW, Molina AJA, Manor U, Marek K, O'Keefe DD, Pinto AFM, Sacco A, Sharpee TO, Shokriev MN, Zambetti S. PMID: 34370163; PMCID: PMC8599742.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    33. The role of retrotransposable elements in ageing and age-associated diseases. Nature. 2021 08; 596(7870):43-53. Gorbunova V, Seluanov A, Mita P, McKerrow W, Fenyö D, Boeke JD, Linker SB, Gage FH, Kreiling JA, Petrashen AP, Woodham TA, Taylor JR, Helfand SL, Sedivy JM. PMID: 34349292; PMCID: PMC8600649.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    34. AAV ablates neurogenesis in the adult murine hippocampus. Elife. 2021 07 14; 10. Johnston S, Parylak SL, Kim S, Mac N, Lim C, Gallina I, Bloyd C, Newberry A, Saavedra CD, Novak O, Gonçalves JT, Gage FH, Shtrahman M. PMID: 34259630; PMCID: PMC8331179.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    35. The Rhox gene cluster suppresses germline LINE1 transposition. Proc Natl Acad Sci U S A. 2021 06 08; 118(23). Tan K, Kim ME, Song HW, Skarbrevik D, Babajanian E, Bedrosian TA, Gage FH, Wilkinson MF. PMID: 34083437; PMCID: PMC8201764.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    36. Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho. Mol Psychiatry. 2021 11; 26(11):6365-6379. Dias GP, Murphy T, Stangl D, Ahmet S, Morisse B, Nix A, Aimone LJ, Aimone JB, Kuro-O M, Gage FH, Thuret S. PMID: 34031536; PMCID: PMC8760057.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    37. To eat, or not to eat, that is the question: Neural stem cells escape phagocytosis in autism with macrocephaly. Proc Natl Acad Sci U S A. 2021 05 11; 118(19). Schafer ST, Gage FH. PMID: 33883269; PMCID: PMC8126768.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    38. Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients. Cell Stem Cell. 2021 09 02; 28(9):1533-1548.e6. Mertens J, Herdy JR, Traxler L, Schafer ST, Schlachetzki JCM, Böhnke L, Reid DA, Lee H, Zangwill D, Fernandes DP, Agarwal RK, Lucciola R, Zhou-Yang L, Karbacher L, Edenhofer F, Stern S, Horvath S, Paquola ACM, Glass CK, Yuan SH, Ku M, Szücs A, Goldstein LSB, Galasko D, Gage FH. PMID: 33910058; PMCID: PMC8423435.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    39. Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons. Science. 2021 04 02; 372(6537):91-94. Reid DA, Reed PJ, Schlachetzki JCM, Nitulescu II, Chou G, Tsui EC, Jones JR, Chandran S, Lu AT, McClain CA, Ooi JH, Wang TW, Lana AJ, Linker SB, Ricciardulli AS, Lau S, Schafer ST, Horvath S, Dixon JR, Hah N, Glass CK, Gage FH. PMID: 33795458; PMCID: PMC9179101.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    40. Sensing serotonin secreted from human serotonergic neurons using aptamer-modified nanopipettes. Mol Psychiatry. 2021 07; 26(7):2753-2763. Nakatsuka N, Heard KJ, Faillétaz A, Momotenko D, Vörös J, Gage FH, Vadodaria KC. PMID: 33767349; PMCID: PMC9997689.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    41. Circadian rhythms in bipolar disorder patient-derived neurons predict lithium response: preliminary studies. Mol Psychiatry. 2021 07; 26(7):3383-3394. Mishra HK, Ying NM, Luis A, Wei H, Nguyen M, Nakhla T, Vandenburgh S, Alda M, Berrettini WH, Brennand KJ, Calabrese JR, Coryell WH, Frye MA, Gage FH, Gershon ES, McInnis MG, Nievergelt CM, Nurnberger JI, Shilling PD, Oedegaard KJ, Zandi PP, Pharmacogenomics of Bipolar Disorder Study, Kelsoe JR, Welsh DK, McCarthy MJ. PMID: 33674753; PMCID: PMC8418615.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    42. Altered Neuronal Support and Inflammatory Response in Bipolar Disorder Patient-Derived Astrocytes. Stem Cell Reports. 2021 04 13; 16(4):825-835. Vadodaria KC, Mendes APD, Mei A, Racha V, Erikson G, Shokhirev MN, Oefner R, Heard KJ, McCarthy MJ, Eyler L, Kelsoe JR, Santos R, Marchetto MC, Gage FH. PMID: 33667413; PMCID: PMC8072028.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    43. The When and Where: Molecular and Cellular Convergence in Autism. Biol Psychiatry. 2021 03 01; 89(5):419-420. Schafer ST, Gage FH. PMID: 33541523.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    44. Cytoplasmic synthesis of endogenous Alu complementary DNA via reverse transcription and implications in age-related macular degeneration. Proc Natl Acad Sci U S A. 2021 02 09; 118(6). Fukuda S, Varshney A, Fowler BJ, Wang SB, Narendran S, Ambati K, Yasuma T, Magagnoli J, Leung H, Hirahara S, Nagasaka Y, Yasuma R, Apicella I, Pereira F, Makin RD, Magner E, Liu X, Sun J, Wang M, Baker K, Marion KM, Huang X, Baghdasaryan E, Ambati M, Ambati VL, Pandey A, Pandya L, Cummings T, Banerjee D, Huang P, Yerramothu P, Tolstonog GV, Held U, Erwin JA, Paquola ACM, Herdy JR, Ogura Y, Terasaki H, Oshika T, Darwish S, Singh RK, Mozaffari S, Bhattarai D, Kim KB, Hardin JW, Bennett CL, Hinton DR, Hanson TE, Röver C, Parang K, Kerur N, Liu J, Werner BC, Sutton SS, Sadda SR, Schumann GG, Gelfand BD, Gage FH, Ambati J. PMID: 33526699; PMCID: PMC8017980.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    45. Deficient LEF1 expression is associated with lithium resistance and hyperexcitability in neurons derived from bipolar disorder patients. Mol Psychiatry. 2021 06; 26(6):2440-2456. Santos R, Linker SB, Stern S, Mendes APD, Shokhirev MN, Erikson G, Randolph-Moore L, Racha V, Kim Y, Kelsoe JR, Bang AG, Alda M, Marchetto MC, Gage FH. PMID: 33398088; PMCID: PMC9129103.
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    46. Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis. EMBO J. 2021 02 01; 40(3):e105819. Bedrosian TA, Houtman J, Eguiguren JS, Ghassemzadeh S, Rund N, Novaresi NM, Hu L, Parylak SL, Denli AM, Randolph-Moore L, Namba T, Gage FH, Toda T. PMID: 33300615; PMCID: PMC7849303.
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    47. Synaptotagmin-7 deficiency induces mania-like behavioral abnormalities through attenuating GluN2B activity. Proc Natl Acad Sci U S A. 2020 12 08; 117(49):31438-31447. Wang QW, Lu SY, Liu YN, Chen Y, Wei H, Shen W, Chen YF, Fu CL, Wang YH, Dai A, Huang X, Gage FH, Xu Q, Yao J. PMID: 33229564; PMCID: PMC7733786.
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    48. Identification of bona fide B2 SINE retrotransposon transcription through single-nucleus RNA-seq of the mouse hippocampus. Genome Res. 2020 11; 30(11):1643-1654. Linker SB, Randolph-Moore L, Kottilil K, Qiu F, Jaeger BN, Barron J, Gage FH. PMID: 33122305; PMCID: PMC7605253.
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    49. Inositol monophosphatase 1 (IMPA1) mutation in intellectual disability patients impairs neurogenesis but not gliogenesis. Mol Psychiatry. 2021 07; 26(7):3558-3571. Figueiredo T, Mendes APD, Moreira DP, Goulart E, Oliveira D, Kobayashi GS, Stern S, Kok F, Marchetto MC, Santos R, Gage FH, Zatz M. PMID: 32839513.
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    50. Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination. J Biol Chem. 2020 08 21; 295(34):12233-12246. Kerman BE, Genoud S, Kurt Vatandaslar B, Denli AM, Georges Ghosh S, Xu X, Yeo GW, Aimone JB, Gage FH. PMID: 32647008; PMCID: PMC7443494.
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    51. Cellular complexity in brain organoids: Current progress and unsolved issues. Semin Cell Dev Biol. 2021 03; 111:32-39. Mansour AA, Schafer ST, Gage FH. PMID: 32499191.
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    52. Modeling Brain Disorders Using Induced Pluripotent Stem Cells. Cold Spring Harb Perspect Biol. 2020 06 01; 12(6). Vadodaria KC, Jones JR, Linker S, Gage FH. PMID: 31767646; PMCID: PMC7263088.
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    53. Loss of the neural-specific BAF subunit ACTL6B relieves repression of early response genes and causes recessive autism. Proc Natl Acad Sci U S A. 2020 05 05; 117(18):10055-10066. Wenderski W, Wang L, Krokhotin A, Walsh JJ, Li H, Shoji H, Ghosh S, George RD, Miller EL, Elias L, Gillespie MA, Son EY, Staahl BT, Baek ST, Stanley V, Moncada C, Shipony Z, Linker SB, Marchetto MCN, Gage FH, Chen D, Sultan T, Zaki MS, Ranish JA, Miyakawa T, Luo L, Malenka RC, Crabtree GR, Gleeson JG. PMID: 32312822; PMCID: PMC7211998.
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    54. Modeling Human Cytomegalovirus-Induced Microcephaly in Human iPSC-Derived Brain Organoids. Cell Rep Med. 2020 04 21; 1(1):100002. Sun G, Chiuppesi F, Chen X, Wang C, Tian E, Nguyen J, Kha M, Trinh D, Zhang H, Marchetto MC, Song H, Ming GL, Gage FH, Diamond DJ, Wussow F, Shi Y. PMID: 33205055; PMCID: PMC7659592.
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    55. Author Correction: Conversion of human fibroblasts to angioblast-like progenitor cells. Nat Methods. 2020 03; 17(3):353. Kurian L, Sancho-Martinez I, Nivet E, Aguirre A, Moon K, Pendaries C, Volle-Challier C, Bono F, Herbert JM, Pulecio J, Xia Y, Li M, Montserrat N, Ruiz S, Dubova I, Rodriguez C, Denli AM, Boscolo FS, Thiagarajan RD, Gage FH, Loring JF, Laurent LC, Belmonte JCI. PMID: 32034376.
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    56. Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice. Proc Natl Acad Sci U S A. 2020 02 25; 117(8):4392-4399. Shen W, Wang QW, Liu YN, Marchetto MC, Linker S, Lu SY, Chen Y, Liu C, Guo C, Xing Z, Shi W, Kelsoe JR, Alda M, Wang H, Zhong Y, Sui SF, Zhao M, Yang Y, Mi S, Cao L, Gage FH, Yao J. PMID: 32041882; PMCID: PMC7049155.
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    57. A Physiological Instability Displayed in Hippocampal Neurons Derived From Lithium-Nonresponsive Bipolar Disorder Patients. Biol Psychiatry. 2020 07 15; 88(2):150-158. Stern S, Sarkar A, Galor D, Stern T, Mei A, Stern Y, Mendes APD, Randolph-Moore L, Rouleau G, Bang AG, Santos R, Alda M, Marchetto MC, Gage FH. PMID: 32278494; PMCID: PMC10871148.
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    58. Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability. Cell Stem Cell. 2020 02 06; 26(2):221-233.e6. Wang M, Wei PC, Lim CK, Gallina IS, Marshall S, Marchetto MC, Alt FW, Gage FH. PMID: 32004479; PMCID: PMC7175642.
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    59. Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis. Cell Stem Cell. 2020 02 06; 26(2):187-204.e10. Zhu Z, Mesci P, Bernatchez JA, Gimple RC, Wang X, Schafer ST, Wettersten HI, Beck S, Clark AE, Wu Q, Prager BC, Kim LJY, Dhanwani R, Sharma S, Garancher A, Weis SM, Mack SC, Negraes PD, Trujillo CA, Penalva LO, Feng J, Lan Z, Zhang R, Wessel AW, Dhawan S, Diamond MS, Chen CC, Wechsler-Reya RJ, Gage FH, Hu H, Siqueira-Neto JL, Muotri AR, Cheresh DA, Rich JN. PMID: 31956038; PMCID: PMC9628766.
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    60. Brain cell type-specific enhancer-promoter interactome maps and disease-risk association. Science. 2019 11 29; 366(6469):1134-1139. Nott A, Holtman IR, Coufal NG, Schlachetzki JCM, Yu M, Hu R, Han CZ, Pena M, Xiao J, Wu Y, Keulen Z, Pasillas MP, O'Connor C, Nickl CK, Schafer ST, Shen Z, Rissman RA, Brewer JB, Gosselin D, Gonda DD, Levy ML, Rosenfeld MG, McVicker G, Gage FH, Ren B, Glass CK. PMID: 31727856; PMCID: PMC7028213.
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    61. Mechanisms Underlying the Hyperexcitability of CA3 and Dentate Gyrus Hippocampal Neurons Derived From Patients With Bipolar Disorder. Biol Psychiatry. 2020 07 15; 88(2):139-149. Stern S, Sarkar A, Stern T, Mei A, Mendes APD, Stern Y, Goldberg G, Galor D, Nguyen T, Randolph-Moore L, Kim Y, Rouleau G, Bang A, Alda M, Santos R, Marchetto MC, Gage FH. PMID: 31732108; PMCID: PMC7108962.
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    62. Dynamical Electrical Complexity Is Reduced during Neuronal Differentiation in Autism Spectrum Disorder. Stem Cell Reports. 2019 09 10; 13(3):474-484. Amatya DN, Linker SB, Mendes APD, Santos R, Erikson G, Shokhirev MN, Zhou Y, Sharpee T, Gage FH, Marchetto MC, Kim Y. PMID: 31474529; PMCID: PMC6739708.
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    63. An Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack KNa Currents. J Neurosci. 2019 09 11; 39(37):7438-7449. Quraishi IH, Stern S, Mangan KP, Zhang Y, Ali SR, Mercier MR, Marchetto MC, McLachlan MJ, Jones EM, Gage FH, Kaczmarek LK. PMID: 31350261; PMCID: PMC6759030.
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    64. Prediction of Response to Drug Therapy in Psychiatric Disorders. Focus (Am Psychiatr Publ). 2019 Jul; 17(3):294-307. Stern S, Linker S, Vadodaria KC, Marchetto MC, Gage FH. PMID: 32015721; PMCID: PMC6996058.
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    65. Corrigendum: Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells. Front Mol Neurosci. 2019; 12:150. van den Hurk M, Erwin JA, Yeo GW, Gage FH, Bardy C. PMID: 31244603; PMCID: PMC6580186.
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    66. Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease. Cell Stem Cell. 2019 Jun 06; 24(6):1006. Sommer A, Marxreiter F, Krach F, Fadler T, Grosch J, Maroni M, Graef D, Eberhardt E, Riemenschneider MJ, Yeo GW, Kohl Z, Xiang W, Gage FH, Winkler J, Prots I, Winner B. PMID: 31173705.
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    67. Adult neurogenesis in mammals. Science. 2019 May 31; 364(6443):827-828. Gage FH. PMID: 31147506.
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    68. Modeling neuropsychiatric disorders using human induced pluripotent stem cells. Protein Cell. 2020 01; 11(1):45-59. Wang M, Zhang L, Gage FH. PMID: 31134525; PMCID: PMC6949328.
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    69. Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons. Elife. 2019 05 17; 8. Herdy J, Schafer S, Kim Y, Ansari Z, Zangwill D, Ku M, Paquola A, Lee H, Mertens J, Gage FH. PMID: 31099332; PMCID: PMC6524968.
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    70. Nerve cells from the brain invade prostate tumours. Nature. 2019 05; 569(7758):637-638. Schafer ST, Gage FH. PMID: 31138915.
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    71. Entrainment of Circadian Rhythms to Temperature Reveals Amplitude Deficits in Fibroblasts from Patients with Bipolar Disorder and Possible Links to Calcium Channels. Mol Neuropsychiatry. 2019 Apr; 5(2):115-124. Nudell V, Wei H, Nievergelt C, Maihofer AX, Shilling P, Alda M, Berrettini WH, Brennand KJ, Calabrese JR, Coryell WH, Covault JM, Frye MA, Gage F, Gershon E, McInnis MG, Nurnberger JI, Oedegaard KJ, Shekhtman T, Zandi PP, Kelsoe JR, McCarthy MJ. PMID: 31192224; PMCID: PMC6528084.
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    72. Altered serotonergic circuitry in SSRI-resistant major depressive disorder patient-derived neurons. Mol Psychiatry. 2019 06; 24(6):808-818. Vadodaria KC, Ji Y, Skime M, Paquola AC, Nelson T, Hall-Flavin D, Heard KJ, Fredlender C, Deng Y, Elkins J, Dani K, Le AT, Marchetto MC, Weinshilboum R, Gage FH. PMID: 30903001; PMCID: PMC7409972.
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    73. Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. Nature. 2019 03; 567(7749):535-539. Farrelly LA, Thompson RE, Zhao S, Lepack AE, Lyu Y, Bhanu NV, Zhang B, Loh YE, Ramakrishnan A, Vadodaria KC, Heard KJ, Erikson G, Nakadai T, Bastle RM, Lukasak BJ, Zebroski H, Alenina N, Bader M, Berton O, Roeder RG, Molina H, Gage FH, Shen L, Garcia BA, Li H, Muir TW, Maze I. PMID: 30867594; PMCID: PMC6557285.
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    74. Microglia, complement and schizophrenia. Nat Neurosci. 2019 03; 22(3):333-334. Wang M, Zhang L, Gage FH. PMID: 30796420.
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    75. Species-specific maturation profiles of human, chimpanzee and bonobo neural cells. Elife. 2019 02 07; 8. Marchetto MC, Hrvoj-Mihic B, Kerman BE, Yu DX, Vadodaria KC, Linker SB, Narvaiza I, Santos R, Denli AM, Mendes AP, Oefner R, Cook J, McHenry L, Grasmick JM, Heard K, Fredlender C, Randolph-Moore L, Kshirsagar R, Xenitopoulos R, Chou G, Hah N, Muotri AR, Padmanabhan K, Semendeferi K, Gage FH. PMID: 30730291; PMCID: PMC6366899.
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    76. Mitochondria, Metabolism, and Redox Mechanisms in Psychiatric Disorders. Antioxid Redox Signal. 2019 08 01; 31(4):275-317. Kim Y, Vadodaria KC, Lenkei Z, Kato T, Gage FH, Marchetto MC, Santos R. PMID: 30585734; PMCID: PMC6602118.
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    77. Serotonin-induced hyperactivity in SSRI-resistant major depressive disorder patient-derived neurons. Mol Psychiatry. 2019 06; 24(6):795-807. Vadodaria KC, Ji Y, Skime M, Paquola A, Nelson T, Hall-Flavin D, Fredlender C, Heard KJ, Deng Y, Le AT, Dave S, Fung L, Li X, Marchetto MC, Weinshilboum R, Gage FH. PMID: 30700803.
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    78. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 2019 Jan 16; 101(2):349. Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, Corjuc BT, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Mertens J, Troncoso J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman BT. PMID: 30653936; PMCID: PMC6377243.
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    79. BrainImageR: spatiotemporal gene set analysis referencing the human brain. Bioinformatics. 2019 01 15; 35(2):343-345. Linker SB, Hsu JY, Pfaff A, Amatya D, Ko SM, Voter S, Wong Q, Gage FH. PMID: 30010719; PMCID: PMC6657270.
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    80. Centrifugal Inputs to the Main Olfactory Bulb Revealed Through Whole Brain Circuit-Mapping. Front Neuroanat. 2018; 12:115. Padmanabhan K, Osakada F, Tarabrina A, Kizer E, Callaway EM, Gage FH, Sejnowski TJ. PMID: 30666191; PMCID: PMC6330333.
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    81. Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons. Nat Neurosci. 2019 02; 22(2):243-255. Schafer ST, Paquola ACM, Stern S, Gosselin D, Ku M, Pena M, Kuret TJM, Liyanage M, Mansour AA, Jaeger BN, Marchetto MC, Glass CK, Mertens J, Gage FH. PMID: 30617258; PMCID: PMC6402576.
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    82. Limits to human neurogenesis-really? Mol Psychiatry. 2020 10; 25(10):2207-2209. Lucassen PJ, Toni N, Kempermann G, Frisen J, Gage FH, Swaab DF. PMID: 30617274; PMCID: PMC7515796.
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    83. Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder. Neuropsychopharmacology. 2019 02; 44(3):620-628. McCarthy MJ, Wei H, Nievergelt CM, Stautland A, Maihofer AX, Welsh DK, Shilling P, Alda M, Alliey-Rodriguez N, Anand A, Andreasson OA, Balaraman Y, Berrettini WH, Bertram H, Brennand KJ, Calabrese JR, Calkin CV, Claasen A, Conroy C, Coryell WH, Craig DW, D'Arcangelo N, Demodena A, Djurovic S, Feeder S, Fisher C, Frazier N, Frye MA, Gage FH, Gao K, Garnham J, Gershon ES, Glazer K, Goes F, Goto T, Harrington G, Jakobsen P, Kamali M, Karberg E, Kelly M, Leckband SG, Lohoff F, McInnis MG, Mondimore F, Morken G, Nurnberger JI, Obral S, Oedegaard KJ, Ortiz A, Ritchey M, Ryan K, Schinagle M, Schoeyen H, Schwebel C, Shaw M, Shekhtman T, Slaney C, Stapp E, Szelinger S, Tarwater B, Zandi PP, Kelsoe JR. PMID: 30487653; PMCID: PMC6333516.
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    84. Long-Term Labeling of Hippocampal Neural Stem Cells by a Lentiviral Vector. Front Mol Neurosci. 2018; 11:415. Suh H, Zhou QG, Fernandez-Carasa I, Clemenson GD, Pons-Espinal M, Ro EJ, Marti M, Raya A, Gage FH, Consiglio A. PMID: 30498432; PMCID: PMC6249367.
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    85. Adult Hippocampal Neurogenesis: A Coming-of-Age Story. J Neurosci. 2018 12 05; 38(49):10401-10410. Kuhn HG, Toda T, Gage FH. PMID: 30381404; PMCID: PMC6284110.
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    86. Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases. Annu Rev Genet. 2018 11 23; 52:271-293. Mertens J, Reid D, Lau S, Kim Y, Gage FH. PMID: 30208291; PMCID: PMC6415910.
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    87. Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model. Science. 2018 09 07; 361(6406). Choi SH, Bylykbashi E, Chatila ZK, Lee SW, Pulli B, Clemenson GD, Kim E, Rompala A, Oram MK, Asselin C, Aronson J, Zhang C, Miller SJ, Lesinski A, Chen JW, Kim DY, van Praag H, Spiegelman BM, Gage FH, Tanzi RE. PMID: 30190379; PMCID: PMC6149542.
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    88. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 2018 09 05; 99(5):925-940.e7. Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, Corjuc BT, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Mertens J, Troncoso J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman BT. PMID: 30189209; PMCID: PMC6240334.
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    89. Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells. Front Mol Neurosci. 2018; 11:261. van den Hurk M, Erwin JA, Yeo GW, Gage FH, Bardy C. PMID: 30147644; PMCID: PMC6096303.
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    90. A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons. Nat Commun. 2018 08 06; 9(1):3084. Jaeger BN, Linker SB, Parylak SL, Barron JJ, Gallina IS, Saavedra CD, Fitzpatrick C, Lim CK, Schafer ST, Lacar B, Jessberger S, Gage FH. PMID: 30082781; PMCID: PMC6079101.
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    91. Erratum: An in vivo model of functional and vascularized human brain organoids. Nat Biotechnol. 2018 08 06; 36(8):772. Mansour AA, Gonçalves JT, Bloyd CW, Li H, Fernandes S, Quang D, Johnston S, Parylak SL, Jin X, Gage FH. PMID: 30080830.
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    92. Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease. Cell Stem Cell. 2018 Jul 05; 23(1):123-131.e6. Sommer A, Marxreiter F, Krach F, Fadler T, Grosch J, Maroni M, Graef D, Eberhardt E, Riemenschneider MJ, Yeo GW, Kohl Z, Xiang W, Gage FH, Winkler J, Prots I, Winner B. PMID: 29979986.
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    93. Author Correction: L1-associated genomic regions are deleted in somatic cells of the healthy human brain. Nat Neurosci. 2018 Jul; 21(7):1016. Erwin JA, Paquola ACM, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FIA, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage FH. PMID: 29703932.
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    94. Author Correction: CRISPR interference-based specific and efficient gene inactivation in the brain. Nat Neurosci. 2018 Jun; 21(6):894. Zheng Y, Shen W, Zhang J, Yang B, Liu YN, Qi H, Yu X, Lu SY, Chen Y, Xu YZ, Li Y, Gage FH, Mi S, Yao J. PMID: 29545585.
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    95. Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile. Cell Rep. 2018 05 29; 23(9):2550-2558. Kim Y, Zheng X, Ansari Z, Bunnell MC, Herdy JR, Traxler L, Lee H, Paquola ACM, Blithikioti C, Ku M, Schlachetzki JCM, Winkler J, Edenhofer F, Glass CK, Paucar AA, Jaeger BN, Pham S, Boyer L, Campbell BC, Hunter T, Mertens J, Gage FH. PMID: 29847787; PMCID: PMC6478017.
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    96. Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs. Sci Transl Med. 2018 05 09; 10(440). Strnadel J, Carromeu C, Bardy C, Navarro M, Platoshyn O, Glud AN, Marsala S, Kafka J, Miyanohara A, Kato T, Tadokoro T, Hefferan MP, Kamizato K, Yoshizumi T, Juhas S, Juhasova J, Ho CS, Kheradmand T, Chen P, Bohaciakova D, Hruska-Plochan M, Todd AJ, Driscoll SP, Glenn TD, Pfaff SL, Klima J, Ciacci J, Curtis E, Gage FH, Bui J, Yamada K, Muotri AR, Marsala M. PMID: 29743351.
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    97. Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro. Cell Stem Cell. 2018 05 03; 22(5):684-697.e9. Sarkar A, Mei A, Paquola ACM, Stern S, Bardy C, Klug JR, Kim S, Neshat N, Kim HJ, Ku M, Shokhirev MN, Adamowicz DH, Marchetto MC, Jappelli R, Erwin JA, Padmanabhan K, Shtrahman M, Jin X, Gage FH. PMID: 29727680; PMCID: PMC6345574.
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    98. Prediction of response to drug therapy in psychiatric disorders. Open Biol. 2018 05; 8(5). Stern S, Linker S, Vadodaria KC, Marchetto MC, Gage FH. PMID: 29794033; PMCID: PMC5990649.
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    99. The role of adult hippocampal neurogenesis in brain health and disease. Mol Psychiatry. 2019 01; 24(1):67-87. Toda T, Parylak SL, Linker SB, Gage FH. PMID: 29679070; PMCID: PMC6195869.
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    100. Human Adult Neurogenesis: Evidence and Remaining Questions. Cell Stem Cell. 2018 Jul 05; 23(1):25-30. Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, Kuhn HG, Jessberger S, Frankland PW, Cameron HA, Gould E, Hen R, Abrous DN, Toni N, Schinder AF, Zhao X, Lucassen PJ, Frisén J. PMID: 29681514; PMCID: PMC6035081.
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    101. An in vivo model of functional and vascularized human brain organoids. Nat Biotechnol. 2018 06; 36(5):432-441. Mansour AA, Gonçalves JT, Bloyd CW, Li H, Fernandes S, Quang D, Johnston S, Parylak SL, Jin X, Gage FH. PMID: 29658944; PMCID: PMC6331203.
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    102. Early life experience drives structural variation of neural genomes in mice. Science. 2018 03 23; 359(6382):1395-1399. Bedrosian TA, Quayle C, Novaresi N, Gage FH. PMID: 29567711.
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    103. CRISPR interference-based specific and efficient gene inactivation in the brain. Nat Neurosci. 2018 03; 21(3):447-454. Zheng Y, Shen W, Zhang J, Yang B, Liu YN, Qi H, Yu X, Lu SY, Chen Y, Xu YZ, Li Y, Gage FH, Mi S, Yao J. PMID: 29403034.
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    104. Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward. Genome Med. 2018 01 04; 10(1):1. Vadodaria KC, Amatya DN, Marchetto MC, Gage FH. PMID: 29301565; PMCID: PMC5755287.
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    105. MicroRNAs in Post-traumatic Stress Disorder. Curr Top Behav Neurosci. 2018; 38:23-46. Snijders C, de Nijs L, Baker DG, Hauger RL, van den Hove D, Kenis G, Nievergelt CM, Boks MP, Vermetten E, Gage FH, Rutten BPF. PMID: 29063484.
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    106. Review: adult neurogenesis contributes to hippocampal plasticity. Cell Tissue Res. 2018 Sep; 373(3):693-709. Toda T, Gage FH. PMID: 29185071.
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    107. Mechanisms of dietary flavonoid action in neuronal function and neuroinflammation. Mol Aspects Med. 2018 06; 61:50-62. Jaeger BN, Parylak SL, Gage FH. PMID: 29117513.
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    108. Corrigendum: L1-associated genomic regions are deleted in somatic cells of the healthy human brain. Nat Neurosci. 2017 Sep 28; 20(10):1427. Erwin JA, Paquola ACM, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FIA, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage FH. PMID: 28949329.
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    109. An in vitro model of lissencephaly: expanding the role of DCX during neurogenesis. Mol Psychiatry. 2018 07; 23(7):1674-1684. Shahsavani M, Pronk RJ, Falk R, Lam M, Moslem M, Linker SB, Salma J, Day K, Schuster J, Anderlid BM, Dahl N, Gage FH, Falk A. PMID: 28924182.
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    110. Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells. Cell Stem Cell. 2017 Nov 02; 21(5):618-634.e7. Toda T, Hsu JY, Linker SB, Hu L, Schafer ST, Mertens J, Jacinto FV, Hetzer MW, Gage FH. PMID: 28919367.
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    111. Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells. Cell Rep. 2017 09 05; 20(10):2525. Topol A, Zhu S, Hartley BJ, English J, Hauberg ME, Tran N, Rittenhouse CA, Simone A, Ruderfer DM, Johnson J, Readhead B, Hadas Y, Gochman PA, Wang YC, Shah H, Cagney G, Rapoport J, Gage FH, Dudley JT, Sklar P, Mattheisen M, Cotter D, Fang G, Brennand KJ. PMID: 28877483; PMCID: PMC5599129.
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    112. Serotonin in psychiatry: in vitro disease modeling using patient-derived neurons. Cell Tissue Res. 2018 01; 371(1):161-170. Vadodaria KC, Stern S, Marchetto MC, Gage FH. PMID: 28812143.
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    114. Intact piRNA pathway prevents L1 mobilization in male meiosis. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):E5635-E5644. Newkirk SJ, Lee S, Grandi FC, Gaysinskaya V, Rosser JM, Vanden Berg N, Hogarth CA, Marchetto MCN, Muotri AR, Griswold MD, Ye P, Bortvin A, Gage FH, Boeke JD, An W. PMID: 28630288; PMCID: PMC5514719.
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    120. Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation. Nat Commun. 2017 03 17; 8:15047. Lacar B, Linker SB, Jaeger BN, Krishnaswami SR, Barron JJ, Kelder MJ, Parylak SL, Paquola AC, Venepally P, Novotny M, O'Connor C, Fitzpatrick C, Erwin JA, Hsu JY, Husband D, McConnell MJ, Lasken R, Gage FH. PMID: 28303884; PMCID: PMC5357833.
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    121. Conserved expression of transposon-derived non-coding transcripts in primate stem cells. BMC Genomics. 2017 02 28; 18(1):214. Ramsay L, Marchetto MC, Caron M, Chen SH, Busche S, Kwan T, Pastinen T, Gage FH, Bourque G. PMID: 28245871; PMCID: PMC5331655.
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    128. Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology. Mol Psychiatry. 2016 11; 21(11):1573-1588. Bardy C, van den Hurk M, Kakaradov B, Erwin JA, Jaeger BN, Hernandez RV, Eames T, Paucar AA, Gorris M, Marchand C, Jappelli R, Barron J, Bryant AK, Kellogg M, Lasken RS, Rutten BP, Steinbusch HW, Yeo GW, Gage FH. PMID: 27698428; PMCID: PMC5071135.
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    135. Diverse Representations of Olfactory Information in Centrifugal Feedback Projections. J Neurosci. 2016 07 13; 36(28):7535-45. Padmanabhan K, Osakada F, Tarabrina A, Kizer E, Callaway EM, Gage FH, Sejnowski TJ. PMID: 27413162; PMCID: PMC4945671.
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    136. Functional Implications of miR-19 in the Migration of Newborn Neurons in the Adult Brain. Neuron. 2016 07 06; 91(1):79-89. Han J, Kim HJ, Schafer ST, Paquola A, Clemenson GD, Toda T, Oh J, Pankonin AR, Lee BS, Johnston ST, Sarkar A, Denli AM, Gage FH. PMID: 27387650.
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    137. Aging and Rejuvenation: Insights from Rusty Gage, Leonard Guarente, and Amy Wagers. Trends Mol Med. 2016 08; 22(8):633-634. Gage FH, Guarente LP, Wagers AJ. PMID: 27396512.
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    138. Altered proliferation and networks in neural cells derived from idiopathic autistic individuals. Mol Psychiatry. 2017 06; 22(6):820-835. Marchetto MC, Belinson H, Tian Y, Freitas BC, Fu C, Vadodaria K, Beltrao-Braga P, Trujillo CA, Mendes APD, Padmanabhan K, Nunez Y, Ou J, Ghosh H, Wright R, Brennand K, Pierce K, Eichenfield L, Pramparo T, Eyler L, Barnes CC, Courchesne E, Geschwind DH, Gage FH, Wynshaw-Boris A, Muotri AR. PMID: 27378147; PMCID: PMC5215991.
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    140. Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation. Elife. 2016 06 10; 5. Zheng X, Boyer L, Jin M, Mertens J, Kim Y, Ma L, Ma L, Hamm M, Gage FH, Hunter T. PMID: 27282387; PMCID: PMC4963198.
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    150. The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity. J Neurosci. 2016 Apr 13; 36(15):4259-75. Harrison BJ, Venkat G, Lamb JL, Hutson TH, Drury C, Rau KK, Bunge MB, Mendell LM, Gage FH, Johnson RD, Hill CE, Rouchka EC, Moon LD, Petruska JC. PMID: 27076424; PMCID: PMC4829650.
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    152. 2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size. Cell Stem Cell. 2016 Apr 07; 18(4):467-80. Otani T, Marchetto MC, Gage FH, Simons BD, Livesey FJ. PMID: 27049876; PMCID: PMC4826446.
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    156. Training the next generation of biomedical investigators in glycosciences. J Clin Invest. 2016 Feb; 126(2):405-8. Agre P, Bertozzi C, Bissell M, Campbell KP, Cummings RD, Desai UR, Estes M, Flotte T, Fogleman G, Gage F, Ginsburg D, Gordon JI, Hart G, Hascall V, Kiessling L, Kornfeld S, Lowe J, Magnani J, Mahal LK, Medzhitov R, Roberts RJ, Sackstein R, Sarkar R, Schnaar R, Schwartz N, Varki A, Walt D, Weissman I. PMID: 26829621; PMCID: PMC4731185.
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    378. Endogenous neurogenesis replaces oligodendrocytes and astrocytes after primate spinal cord injury. J Neurosci. 2006 Feb 22; 26(8):2157-66. Yang H, Lu P, McKay HM, Bernot T, Keirstead H, Steward O, Gage FH, Edgerton VR, Tuszynski MH. PMID: 16495442; PMCID: PMC6674802.
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    379. Differential properties of adult rat and mouse brain-derived neural stem/progenitor cells. Mol Cell Neurosci. 2006 Mar; 31(3):560-73. Ray J, Gage FH. PMID: 16426857.
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    380. A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells. Angew Chem Int Ed Engl. 2006 Jan 16; 45(4):591-3. Warashina M, Min KH, Kuwabara T, Huynh A, Gage FH, Schultz PG, Ding S. PMID: 16323231.
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    381. Unconventional translation of mammalian LINE-1 retrotransposons. Genes Dev. 2006 Jan 15; 20(2):210-24. Alisch RS, Garcia-Perez JL, Muotri AR, Gage FH, Moran JV. PMID: 16418485; PMCID: PMC1356112.
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    382. Natural variation and genetic covariance in adult hippocampal neurogenesis. Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3):780-5. Kempermann G, Chesler EJ, Lu L, Williams RW, Gage FH. PMID: 16407118; PMCID: PMC1325968.
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    383. Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus. J Neurosci. 2006 Jan 04; 26(1):3-11. Zhao C, Teng EM, Summers RG, Ming GL, Gage FH. PMID: 16399667; PMCID: PMC6674324.
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    384. Retrovirus-mediated single-cell gene knockout technique in adult newborn neurons in vivo. Nat Protoc. 2006; 1(6):3049-55. Tashiro A, Zhao C, Gage FH. PMID: 17406567.
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    385. Neurogenic niche modulation by activated microglia: transforming growth factor beta increases neurogenesis in the adult dentate gyrus. Eur J Neurosci. 2006 Jan; 23(1):83-93. Battista D, Ferrari CC, Gage FH, Pitossi FJ. PMID: 16420418.
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    386. Noncoding RNAs in the mammalian central nervous system. Annu Rev Neurosci. 2006; 29:77-103. Cao X, Yeo G, Muotri AR, Kuwabara T, Gage FH. PMID: 16776580.
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    387. Motor enrichment sustains hindlimb movement recovered after spinal cord injury and glial transplantation. Restor Neurol Neurosci. 2006; 24(3):147-61. Moon LD, Leasure JL, Gage FH, Bunge MB. PMID: 16873970.
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    388. In vivo evidence for radial migration of neurons by long-distance somal translocation in the developing ferret visual cortex. Cereb Cortex. 2006 Nov; 16(11):1571-83. Borrell V, Kaspar BK, Gage FH, Callaway EM. PMID: 16357334.
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    389. Development of functional human embryonic stem cell-derived neurons in mouse brain. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18644-8. Muotri AR, Nakashima K, Toni N, Sandler VM, Gage FH. PMID: 16352714; PMCID: PMC1317971.
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    390. Wnt signalling regulates adult hippocampal neurogenesis. Nature. 2005 Oct 27; 437(7063):1370-5. Lie DC, Colamarino SA, Song HJ, Désiré L, Mira H, Consiglio A, Lein ES, Jessberger S, Lansford H, Dearie AR, Gage FH. PMID: 16251967.
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    391. Chromatin remodeling in neural development and plasticity. Curr Opin Cell Biol. 2005 Dec; 17(6):664-71. Hsieh J, Gage FH. PMID: 16226449.
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    392. Neuronal and glial cell biology. Curr Opin Neurobiol. 2005 Oct; 15(5):497-9. Gage FH, McAllister AK. PMID: 16143511.
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    393. Regulatable acetylcholine-producing fibroblasts enhance cognitive performance. Mol Ther. 2006 Jan; 13(1):175-82. Pizzo DP, Coufal NG, Lortie MJ, Gage FH, Thal LJ. PMID: 16185935.
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    395. Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):14069-74. Cummings BJ, Uchida N, Tamaki SJ, Salazar DL, Hooshmand M, Summers R, Gage FH, Anderson AJ. PMID: 16172374; PMCID: PMC1216836.
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    396. Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nat Neurosci. 2005 Oct; 8(10):1343-9. Singer O, Marr RA, Rockenstein E, Crews L, Coufal NG, Gage FH, Verma IM, Masliah E. PMID: 16136043.
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    397. Targeted expression of IGF-1 in the central nervous system fails to protect mice from experimental autoimmune encephalomyelitis. J Neuroimmunol. 2005 Nov; 168(1-2):40-5. Genoud S, Maricic I, Kumar V, Gage FH. PMID: 16120466.
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    398. A small gem with great powers: geminin keeps neural progenitors thriving. Dev Cell. 2005 Aug; 9(2):171-2. Aigner S, Gage FH. PMID: 16054024.
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    399. Proliferation, migration, neuronal differentiation, and long-term survival of new cells in the adult zebrafish brain. J Comp Neurol. 2005 Aug 01; 488(3):290-319. Zupanc GK, Hinsch K, Gage FH. PMID: 15952170.
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    400. Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition. Nature. 2005 Jun 16; 435(7044):903-10. Muotri AR, Chu VT, Marchetto MC, Deng W, Moran JV, Gage FH. PMID: 15959507.
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    401. Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism. Neuron. 2005 May 19; 46(4):569-79. Lin W, Dominguez B, Yang J, Aryal P, Brandon EP, Gage FH, Lee KF. PMID: 15944126.
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    402. Virus-delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis. Ann Neurol. 2005 May; 57(5):773-6. Miller TM, Kaspar BK, Kops GJ, Yamanaka K, Christian LJ, Gage FH, Cleveland DW. PMID: 15852369; PMCID: PMC1351126.
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    403. Synergy of insulin-like growth factor-1 and exercise in amyotrophic lateral sclerosis. Ann Neurol. 2005 May; 57(5):649-55. Kaspar BK, Frost LM, Christian L, Umapathi P, Gage FH. PMID: 15852403.
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    404. Redefining the boundaries of the hippocampal CA2 subfield in the mouse using gene expression and 3-dimensional reconstruction. J Comp Neurol. 2005 Apr 25; 485(1):1-10. Lein ES, Callaway EM, Albright TD, Gage FH. PMID: 15776443.
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    405. Quantitative analysis of gene expression in living adult neural stem cells by gene trapping. Nat Methods. 2005 May; 2(5):363-70. Scheel JR, Ray J, Gage FH, Barlow C. PMID: 15846364.
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    406. DNA repair proteins affect the lifecycle of herpes simplex virus 1. Proc Natl Acad Sci U S A. 2005 Apr 19; 102(16):5844-9. Lilley CE, Carson CT, Muotri AR, Gage FH, Weitzman MD. PMID: 15824307; PMCID: PMC556126.
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    407. Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits. Neuron. 2005 Apr 07; 46(1):37-49. Myers CP, Lewcock JW, Hanson MG, Gosgnach S, Aimone JB, Gage FH, Lee KF, Landmesser LT, Pfaff SL. PMID: 15820692.
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    408. Human embryonic stem cells express an immunogenic nonhuman sialic acid. Nat Med. 2005 Feb; 11(2):228-32. Martin MJ, Muotri A, Gage F, Varki A. PMID: 15685172.
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    410. An antiaggregation gene therapy strategy for Lewy body disease utilizing beta-synuclein lentivirus in a transgenic model. Gene Ther. 2004 Dec; 11(23):1713-23. Hashimoto M, Rockenstein E, Mante M, Crews L, Bar-On P, Gage FH, Marr R, Masliah E. PMID: 15483670.
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    412. Intracerebral transplantation of adult mouse neural progenitor cells into the Niemann-Pick-A mouse leads to a marked decrease in lysosomal storage pathology. J Neurosci. 2004 Nov 24; 24(47):10642-51. Shihabuddin LS, Numan S, Huff MR, Dodge JC, Clarke J, Macauley SL, Yang W, Taksir TV, Parsons G, Passini MA, Gage FH, Stewart GR. PMID: 15564580; PMCID: PMC6730128.
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    413. Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells. Proc Natl Acad Sci U S A. 2004 Nov 23; 101(47):16659-64. Hsieh J, Nakashima K, Kuwabara T, Mejia E, Gage FH. PMID: 15537713; PMCID: PMC527137.
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    414. Microfabricated platform for studying stem cell fates. Biotechnol Bioeng. 2004 Nov 05; 88(3):399-415. Chin VI, Taupin P, Sanga S, Scheel J, Gage FH, Bhatia SN. PMID: 15486946.
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    415. Robust in vivo gene transfer into adult mammalian neural stem cells by lentiviral vectors. Proc Natl Acad Sci U S A. 2004 Oct 12; 101(41):14835-40. Consiglio A, Gritti A, Dolcetta D, Follenzi A, Bordignon C, Gage FH, Vescovi AL, Naldini L. PMID: 15466696; PMCID: PMC522006.
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    416. Epigenetic control of neural stem cell fate. Curr Opin Genet Dev. 2004 Oct; 14(5):461-9. Hsieh J, Gage FH. PMID: 15380235.
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    417. A hypothesis about the role of adult neurogenesis in hippocampal function. Physiology (Bethesda). 2004 Oct; 19:253-61. Schinder AF, Gage FH. PMID: 15381753.
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    418. Optimizing donor heart outcome after prolonged storage with endothelial function analysis and continuous perfusion. Ann Thorac Surg. 2004 Oct; 78(4):1362-70;; discussion 1362-70. Poston RS, Gu J, Prastein D, Gage F, Hoffman JW, Kwon M, Azimzadeh A, Pierson RN, Griffith BP. PMID: 15464500.
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    419. Cell fusion-independent differentiation of neural stem cells to the endothelial lineage. Nature. 2004 Jul 15; 430(6997):350-6. Wurmser AE, Nakashima K, Summers RG, Toni N, D'Amour KA, Lie DC, Gage FH. PMID: 15254537.
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    420. Long-term production of choline acetyltransferase in the CNS after transplantation of fibroblasts modified with a regulatable vector. Brain Res Mol Brain Res. 2004 Jul 05; 126(1):1-13. Pizzo DP, Paban V, Coufal NG, Gage FH, Thal LJ. PMID: 15207910.
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    421. Choline transporter 1 maintains cholinergic function in choline acetyltransferase haploinsufficiency. J Neurosci. 2004 Jun 16; 24(24):5459-66. Brandon EP, Mellott T, Pizzo DP, Coufal N, D'Amour KA, Gobeske K, Lortie M, López-Coviella I, Berse B, Thal LJ, Gage FH, Blusztajn JK. PMID: 15201317; PMCID: PMC6729318.
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    422. Structural plasticity of the adult brain. Dialogues Clin Neurosci. 2004 Jun; 6(2):135-41. Gage FH. PMID: 22034393; PMCID: PMC3181802.
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    425. Defining a molecular atlas of the hippocampus using DNA microarrays and high-throughput in situ hybridization. J Neurosci. 2004 Apr 14; 24(15):3879-89. Lein ES, Zhao X, Gage FH. PMID: 15084669; PMCID: PMC6729356.
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    426. Functional significance of adult neurogenesis. Curr Opin Neurobiol. 2004 Apr; 14(2):186-91. Kempermann G, Wiskott L, Gage FH. PMID: 15082323.
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    427. Novel neuronal phenotypes from neural progenitor cells. J Neurosci. 2004 Mar 24; 24(12):2886-97. Markakis EA, Palmer TD, Randolph-Moore L, Rakic P, Gage FH. PMID: 15044527; PMCID: PMC3242437.
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    428. A small modulatory dsRNA specifies the fate of adult neural stem cells. Cell. 2004 Mar 19; 116(6):779-93. Kuwabara T, Hsieh J, Nakashima K, Taira K, Gage FH. PMID: 15035981.
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    429. IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes. J Cell Biol. 2004 Jan 05; 164(1):111-22. Hsieh J, Aimone JB, Kaspar BK, Kuwabara T, Nakashima K, Gage FH. PMID: 14709544; PMCID: PMC2171962.
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    430. Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature. 2004 Jan 01; 427(6969):78-83. Shi Y, Chichung Lie D, Taupin P, Nakashima K, Ray J, Yu RT, Gage FH, Evans RM. PMID: 14702088.
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    431. Neprilysin regulates amyloid Beta peptide levels. J Mol Neurosci. 2004; 22(1-2):5-11. Marr RA, Guan H, Rockenstein E, Kindy M, Gage FH, Verma I, Masliah E, Hersh LB. PMID: 14742905.
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    432. Neurogenesis in the adult brain: new strategies for central nervous system diseases. Annu Rev Pharmacol Toxicol. 2004; 44:399-421. Lie DC, Song H, Colamarino SA, Ming GL, Gage FH. PMID: 14744252.
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    433. Embryonic stem cells: staying plastic on plastic. Nat Med. 2004 Jan; 10(1):23-4. Nakashima K, Colamarino S, Gage FH. PMID: 14702626.
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    434. Neurogenesis and neuroadaptation. Neuromolecular Med. 2004; 5(1):1-9. Schaffer DV, Gage FH. PMID: 15001808.
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    435. Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo. Neuroscience. 2004; 124(1):71-9. Farmer J, Zhao X, van Praag H, Wodtke K, Gage FH, Christie BR. PMID: 14960340.
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    436. Vibrating in the background. Nat Genet. 2003 Nov; 35(3):205-7. Muotri AR, Gage FH. PMID: 14593403.
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    437. Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running. Behav Neurosci. 2003 Oct; 117(5):1006-16. Rhodes JS, van Praag H, Jeffrey S, Girard I, Mitchell GS, Garland T, Gage FH. PMID: 14570550.
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    438. Survival and differentiation of adult rat-derived neural progenitor cells transplanted to the striatum of hemiparkinsonian rats. Exp Neurol. 2003 Oct; 183(2):653-64. Dziewczapolski G, Lie DC, Ray J, Gage FH, Shults CW. PMID: 14552907.
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    439. Chronic neurotrophin-3 strengthens synaptic connections to motoneurons in the neonatal rat. J Neurosci. 2003 Sep 24; 23(25):8706-12. Arvanian VL, Horner PJ, Gage FH, Mendell LM. PMID: 14507970; PMCID: PMC6740423.
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    440. Brain, repair yourself. Sci Am. 2003 Sep; 289(3):46-53. Gage FH. PMID: 12951827.
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    441. IGF-I has a direct proliferative effect in adult hippocampal progenitor cells. Mol Cell Neurosci. 2003 Sep; 24(1):23-40. Aberg MA, Aberg ND, Palmer TD, Alborn AM, Carlsson-Skwirut C, Bang P, Rosengren LE, Olsson T, Gage FH, Eriksson PS. PMID: 14550766.
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    442. Genetic and functional differences between multipotent neural and pluripotent embryonic stem cells. Proc Natl Acad Sci U S A. 2003 Sep 30; 100 Suppl 1:11866-72. D'Amour KA, Gage FH. PMID: 12923297; PMCID: PMC304100.
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    443. Stem cells at the dawn of the 21st century. Proc Natl Acad Sci U S A. 2003 Sep 30; 100 Suppl 1:11817-8. Gage FH, Verma IM. PMID: 12915737; PMCID: PMC304091.
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