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Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies. Science. 2024 Aug 23; 385(6711):eabm6131.
Minhas PS, Jones JR, Latif-Hernandez A, Sugiura Y, Durairaj AS, Wang Q, Mhatre SD, Uenaka T, Crapser J, Conley T, Ennerfelt H, Jung YJ, Liu L, Prasad P, Jenkins BC, Ay YA, Matrongolo M, Goodman R, Newmeyer T, Heard K, Kang A, Wilson EN, Yang T, Ullian EM, Serrano GE, Beach TG, Wernig M, Rabinowitz JD, Suematsu M, Longo FM, McReynolds MR, Gage FH, Andreasson KI. PMID: 39172838.
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HumansAnimalsCells
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Modeling Alzheimer's disease using human cell derived brain organoids and 3D models. Front Neurosci. 2024; 18:1434945.
Fernandes S, Revanna J, Pratt J, Hayes N, Marchetto MC, Gage FH. PMID: 39156632; PMCID: PMC11328153.
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PubMed Mentions:
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Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies. bioRxiv. 2024 Jun 28.
Minhas PS, Jones JR, Latif-Hernandez A, Sugiura Y, Durairaj AS, Uenaka T, Wang Q, Mhatre SD, Liu L, Conley T, Ennerfelt H, Jung YJ, Prasad P, Jenkins BC, Goodman R, Newmeyer T, Heard K, Kang A, Wilson EN, Ullian EM, Serrano GE, Beach TG, Rabinowitz JD, Wernig M, Suematsu M, Longo FM, McReynolds MR, Gage FH, Andreasson KI. PMID: 38979192; PMCID: PMC11230169.
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Neuronal senescence may drive brain aging. Science. 2024 Jun 28; 384(6703):1404-1406.
Herdy JR, Mertens J, Gage FH. PMID: 38935713.
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HumansAnimalsCells
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Protocol for the San Diego Nathan Shock Center Clinical Cohort: a new resource for studies of human aging. BMJ Open. 2024 Jun 25; 14(6):e082659.
Phang HJ, Heimler SR, Scandalis LM, Wing D, Moran R, Nichols JF, Moreno D, Shadel GS, Gage FH, Molina AJA. PMID: 38925692; PMCID: PMC11202663.
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PubMed Mentions: Fields:
Translation:
Humans
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High resolution long-read telomere sequencing reveals dynamic mechanisms in aging and cancer. Nat Commun. 2024 Jun 18; 15(1):5149.
Schmidt TT, Tyer C, Rughani P, Haggblom C, Jones JR, Dai X, Frazer KA, Gage FH, Juul S, Hickey S, Karlseder J. PMID: 38890299; PMCID: PMC11189484.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Upregulated ECM genes and increased synaptic activity in Parkinson's human DA neurons with PINK1/ PRKN mutations. NPJ Parkinsons Dis. 2024 May 18; 10(1):103.
Tripathi U, Rosh I, Ben Ezer R, Nayak R, Hussein Y, Choudhary A, Djamus J, Manole A, Houlden H, Gage FH, Stern S. PMID: 38762512; PMCID: PMC11102563.
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PubMed Mentions:
1
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Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission. Mol Psychiatry. 2024 May 04.
Stern S, Zhang L, Wang M, Wright R, Rosh I, Hussein Y, Stern T, Choudhary A, Tripathi U, Reed P, Sadis H, Nayak R, Shemen A, Agarwal K, Cordeiro D, Peles D, Hang Y, Mendes APD, Baul TD, Roth JG, Coorapati S, Boks MP, McCombie WR, Hulshoff Pol H, Brennand KJ, Réthelyi JM, Kahn RS, Marchetto MC, Gage FH. PMID: 38704507.
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PubMed Mentions:
1 Fields:
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Lifelong persistence of nuclear RNAs in the mouse brain. Science. 2024 Apr 05; 384(6691):53-59.
Zocher S, McCloskey A, Karasinsky A, Schulte R, Friedrich U, Lesche M, Rund N, Gage FH, Hetzer MW, Toda T. PMID: 38574132; PMCID: PMC7615865.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Morphological diversification and functional maturation of human astrocytes in glia-enriched cortical organoid transplanted in mouse brain. Nat Biotechnol. 2024 Feb 28.
Wang M, Zhang L, Novak SW, Yu J, Gallina IS, Xu LL, Lim CK, Fernandes S, Shokhirev MN, Williams AE, Saxena MD, Coorapati S, Parylak SL, Quintero C, Molina E, Andrade LR, Manor U, Gage FH. PMID: 38418648; PMCID: PMC11349933.
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PubMed Mentions:
2 Fields:
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Synaptic dysfunction and extracellular matrix dysregulation in dopaminergic neurons from sporadic and E326K-GBA1 Parkinson's disease patients. NPJ Parkinsons Dis. 2024 Feb 19; 10(1):38.
Rosh I, Tripathi U, Hussein Y, Rike WA, Djamus J, Shklyar B, Manole A, Houlden H, Winkler J, Gage FH, Stern S. PMID: 38374278; PMCID: PMC10876637.
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PubMed Mentions:
2
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Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation. Cell Rep. 2024 Feb 27; 43(2):113774.
Toda T, Bedrosian TA, Schafer ST, Cuoco MS, Linker SB, Ghassemzadeh S, Mitchell L, Whiteley JT, Novaresi N, McDonald AH, Gallina IS, Yoon H, Hester ME, Pena M, Lim C, Suljic E, AlFatah Mansour A, Boulard M, Parylak SL, Gage FH. PMID: 38349791; PMCID: PMC10948021.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Tyro3 promotes the maturation of glutamatergic synapses. Front Neurosci. 2024; 18:1327423.
Miao S, Fourgeaud L, Burrola PG, Stern S, Zhang Y, Happonen KE, Novak SW, Gage FH, Lemke G. PMID: 38410160; PMCID: PMC10894971.
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PubMed Mentions:
1
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Human iN neuronal model of schizophrenia displays dysregulation of chromogranin B and related neuropeptide transmitter signatures. Mol Psychiatry. 2024 May; 29(5):1440-1449.
Podvin S, Jones J, Kang A, Goodman R, Reed P, Lietz CB, Then J, Lee KC, Eyler LT, Jeste DV, Gage FH, Hook V. PMID: 38302561; PMCID: PMC11189816.
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PubMed Mentions: Fields:
Translation:
HumansCells
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NGLY1 mutations cause protein aggregation in human neurons. Cell Rep. 2023 12 26; 42(12):113466.
Manole A, Wong T, Rhee A, Novak S, Chin SM, Tsimring K, Paucar A, Williams A, Newmeyer TF, Schafer ST, Rosh I, Kaushik S, Hoffman R, Chen S, Wang G, Snyder M, Cuervo AM, Andrade L, Manor U, Lee K, Jones JR, Stern S, Marchetto MC, Gage FH. PMID: 38039131; PMCID: PMC10826878.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases. Sci Data. 2023 11 20; 10(1):813.
Garrison MA, Jang Y, Bae T, Cherskov A, Emery SB, Fasching L, Jones A, Moldovan JB, Molitor C, Pochareddy S, Peters MA, Shin JH, Wang Y, Yang X, Akbarian S, Chess A, Gage FH, Gleeson JG, Kidd JM, McConnell M, Mills RE, Moran JV, Park PJ, Sestan N, Urban AE, Vaccarino FM, Walsh CA, Weinberger DR, Wheelan SJ, Abyzov A, BSMN Consortium. PMID: 37985666; PMCID: PMC10662356.
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Translation:
Humans
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Immunoglobulin genes expressed in lymphoblastoid cell lines discern and predict lithium response in bipolar disorder patients. Mol Psychiatry. 2023 Oct; 28(10):4280-4293.
Mizrahi L, Choudhary A, Ofer P, Goldberg G, Milanesi E, Kelsoe JR, Gurwitz D, Alda M, Gage FH, Stern S. PMID: 37488168; PMCID: PMC10827667.
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Translation:
HumansCells
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Neural cell state shifts and fate loss in ageing and age-related diseases. Nat Rev Neurol. 2023 07; 19(7):434-443.
Traxler L, Lucciola R, Herdy JR, Jones JR, Mertens J, Gage FH. PMID: 37268723; PMCID: PMC10478103.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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An in vivo neuroimmune organoid model to study human microglia phenotypes. Cell. 2023 05 11; 186(10):2111-2126.e20.
Schafer ST, Mansour AA, Schlachetzki JCM, Pena M, Ghassemzadeh S, Mitchell L, Mar A, Quang D, Stumpf S, Ortiz IS, Lana AJ, Baek C, Zaghal R, Glass CK, Nimmerjahn A, Gage FH. PMID: 37172564; PMCID: PMC10284271.
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PubMed Mentions:
35 Fields:
Translation:
HumansCells
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Novel correlative analysis identifies multiple genomic variations impacting ASD with macrocephaly. Hum Mol Genet. 2023 05 05; 32(10):1589-1606.
Fu C, Ngo J, Zhang S, Lu L, Miron A, Schafer S, Gage FH, Jin F, Schumacher FR, Wynshaw-Boris A. PMID: 36519762; PMCID: PMC10162433.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Contributions of circadian clock genes to cell survival in fibroblast models of lithium-responsive bipolar disorder. Eur Neuropsychopharmacol. 2023 09; 74:1-14.
Mishra HK, Wei H, Rohr KE, Ko I, Nievergelt CM, Maihofer AX, Shilling PD, Alda M, Berrettini WH, Brennand KJ, Calabrese JR, Coryell WH, Frye M, Gage F, Gershon E, McInnis MG, Nurnberger J, Oedegaard KJ, Zandi PP, Kelsoe JR, McCarthy MJ. PMID: 37126998.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Neural Organoids and the Quest to Understand and Treat Psychiatric Disease. Biol Psychiatry. 2023 04 01; 93(7):588-589.
Arlotta P, Gage FH. PMID: 36889858.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis. Mol Psychiatry. 2024 01; 29(1):6-19.
Niemsiri V, Rosenthal SB, Nievergelt CM, Maihofer AX, Marchetto MC, Santos R, Shekhtman T, Alliey-Rodriguez N, Anand A, Balaraman Y, Berrettini WH, Bertram H, Burdick KE, Calabrese JR, Calkin CV, Conroy C, Coryell WH, DeModena A, Eyler LT, Feeder S, Fisher C, Frazier N, Frye MA, Gao K, Garnham J, Gershon ES, Goes FS, Goto T, Harrington GJ, Jakobsen P, Kamali M, Kelly M, Leckband SG, Lohoff FW, McCarthy MJ, McInnis MG, Craig D, Millett CE, Mondimore F, Morken G, Nurnberger JI, Donovan CO, Øedegaard KJ, Ryan K, Schinagle M, Shilling PD, Slaney C, Stapp EK, Stautland A, Tarwater B, Zandi PP, Alda M, Fisch KM, Gage FH, Kelsoe JR. PMID: 36991131; PMCID: PMC11078741.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Adult neurogenesis in the hippocampus. Hippocampus. 2023 04; 33(4):269-270.
Kempermann G, Song H, Gage FH. PMID: 36912499; PMCID: PMC11175592.
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PubMed Mentions:
1 Fields:
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Neuronal activity-related transcription is blunted in immature compared to mature dentate granule cells. Hippocampus. 2023 04; 33(4):412-423.
Parylak SL, Qiu F, Linker SB, Gallina IS, Lim CK, Preciado D, McDonald AH, Zhou X, Gage FH. PMID: 36811254; PMCID: PMC10985790.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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BCI-838, an orally active mGluR2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the PS19 MAPTP301S mouse model of tauopathy. Neurosci Lett. 2023 02 16; 797:137080.
Perez-Garcia G, Bicak M, Haure-Mirande JV, Perez GM, Otero-Pagan A, Gama Sosa MA, De Gasperi R, Sano M, Barlow C, Gage FH, Readhead B, Ehrlich ME, Gandy S, Elder GA. PMID: 36657633; PMCID: PMC9974759.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Transplantation Strategies to Enhance Maturity and Cellular Complexity in Brain Organoids. Biol Psychiatry. 2023 04 01; 93(7):616-621.
Wang M, Gage FH, Schafer ST. PMID: 36739209; PMCID: PMC10662460.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex. Nat Commun. 2022 12 26; 13(1):7945.
Wilson MN, Thunemann M, Liu X, Lu Y, Puppo F, Adams JW, Kim JH, Ramezani M, Pizzo DP, Djurovic S, Andreassen OA, Mansour AA, Gage FH, Muotri AR, Devor A, Kuzum D. PMID: 36572698; PMCID: PMC9792589.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer's disease. Cell Stem Cell. 2022 12 01; 29(12):1637-1652.e6.
Herdy JR, Traxler L, Agarwal RK, Karbacher L, Schlachetzki JCM, Boehnke L, Zangwill D, Galasko D, Glass CK, Mertens J, Gage FH. PMID: 36459967; PMCID: PMC10093780.
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PubMed Mentions:
33 Fields:
Translation:
HumansCells
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Druggable transcriptomic pathways revealed in Parkinson's patient-derived midbrain neurons. NPJ Parkinsons Dis. 2022 Oct 18; 8(1):134.
van den Hurk M, Lau S, Marchetto MC, Mertens J, Stern S, Corti O, Brice A, Winner B, Winkler J, Gage FH, Bardy C. PMID: 36258029; PMCID: PMC9579158.
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PubMed Mentions:
4
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Human-specific regulation of neural maturation identified by cross-primate transcriptomics. Curr Biol. 2022 11 21; 32(22):4797-4807.e5.
Linker SB, Narvaiza I, Hsu JY, Wang M, Qiu F, Mendes APD, Oefner R, Kottilil K, Sharma A, Randolph-Moore L, Mejia E, Santos R, Marchetto MC, Gage FH. PMID: 36228612.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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A nomenclature consensus for nervous system organoids and assembloids. Nature. 2022 09; 609(7929):907-910.
Pa?ca SP, Arlotta P, Bateup HS, Camp JG, Cappello S, Gage FH, Knoblich JA, Kriegstein AR, Lancaster MA, Ming GL, Muotri AR, Park IH, Reiner O, Song H, Studer L, Temple S, Testa G, Treutlein B, Vaccarino FM. PMID: 36171373; PMCID: PMC10571504.
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PubMed Mentions:
51 Fields:
Translation:
HumansCells
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Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer's disease. Cell Metab. 2022 09 06; 34(9):1248-1263.e6.
Traxler L, Herdy JR, Stefanoni D, Eichhorner S, Pelucchi S, Szücs A, Santagostino A, Kim Y, Agarwal RK, Schlachetzki JCM, Glass CK, Lagerwall J, Galasko D, Gage FH, D'Alessandro A, Mertens J. PMID: 35987203; PMCID: PMC9458870.
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PubMed Mentions:
37 Fields:
Translation:
HumansCells
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Reduced synaptic activity and dysregulated extracellular matrix pathways in midbrain neurons from Parkinson's disease patients. NPJ Parkinsons Dis. 2022 Aug 10; 8(1):103.
Stern S, Lau S, Manole A, Rosh I, Percia MM, Ben Ezer R, Shokhirev MN, Qiu F, Schafer S, Mansour AA, Mangan KP, Stern T, Ofer P, Stern Y, Diniz Mendes AP, Djamus J, Moore LR, Nayak R, Laufer SH, Aicher A, Rhee A, Wong TL, Nguyen T, Linker SB, Winner B, Freitas BC, Jones E, Sagi I, Bardy C, Brice A, Winkler J, Marchetto MC, Gage FH. PMID: 35948563; PMCID: PMC9365794.
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PubMed Mentions:
14
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Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability. Science. 2022 07 29; 377(6605):511-517.
Bae T, Fasching L, Wang Y, Shin JH, Suvakov M, Jang Y, Norton S, Dias C, Mariani J, Jourdon A, Wu F, Panda A, Pattni R, Chahine Y, Yeh R, Roberts RC, Huttner A, Kleinman JE, Hyde TM, Straub RE, Walsh CA, Brain Somatic Mosaicism Network§, Urban AE, Leckman JF, Weinberger DR, Vaccarino FM, Abyzov A. PMID: 35901164; PMCID: PMC9420557.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Methods for culturing adult CNS neurons reveal a CNS conditioning effect. Cell Rep Methods. 2022 07 18; 2(7):100255.
van Niekerk EA, Kawaguchi R, Marques de Freria C, Groeniger K, Marchetto MC, Dupraz S, Bradke F, Geschwind DH, Gage FH, Tuszynski MH. PMID: 35880023; PMCID: PMC9308166.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Dynamic Interrogation of Stochastic Transcriptome Trajectories Using Disease Associated Genes Reveals Distinct Origins of Neurological and Psychiatric Disorders. Front Neurosci. 2022; 16:884707.
Bermperidis T, Schafer S, Gage FH, Sejnowski T, Torres EB. PMID: 35720720; PMCID: PMC9201694.
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PubMed Mentions:
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Oleic acid regulates hippocampal neurogenesis as a TLX ligand. Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2203038119.
Shi Y, Evans RM, Gage FH. PMID: 35344400; PMCID: PMC9169763.
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PubMed Mentions:
1 Fields:
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Chronic cortisol differentially impacts stem cell-derived astrocytes from major depressive disorder patients. Transl Psychiatry. 2021 11 30; 11(1):608.
Heard KJ, Shokhirev MN, Becronis C, Fredlender C, Zahid N, Le AT, Ji Y, Skime M, Nelson T, Hall-Flavin D, Weinshilboum R, Gage FH, Vadodaria KC. PMID: 34848679; PMCID: PMC8632962.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Adult neurogenesis in neurological diseases. Science. 2021 Nov 26; 374(6571):1049-1050.
Gage FH. PMID: 34822282.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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The San Diego Nathan Shock Center: tackling the heterogeneity of aging. Geroscience. 2021 10; 43(5):2139-2148.
Shadel GS, Adams PD, Berggren WT, Diedrich JK, Diffenderfer KE, Gage FH, Hah N, Hansen M, Hetzer MW, Molina AJA, Manor U, Marek K, O'Keefe DD, Pinto AFM, Sacco A, Sharpee TO, Shokriev MN, Zambetti S. PMID: 34370163; PMCID: PMC8599742.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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The role of retrotransposable elements in ageing and age-associated diseases. Nature. 2021 08; 596(7870):43-53.
Gorbunova V, Seluanov A, Mita P, McKerrow W, Fenyö D, Boeke JD, Linker SB, Gage FH, Kreiling JA, Petrashen AP, Woodham TA, Taylor JR, Helfand SL, Sedivy JM. PMID: 34349292; PMCID: PMC8600649.
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PubMed Mentions:
91 Fields:
Translation:
HumansAnimalsCells
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AAV ablates neurogenesis in the adult murine hippocampus. Elife. 2021 07 14; 10.
Johnston S, Parylak SL, Kim S, Mac N, Lim C, Gallina I, Bloyd C, Newberry A, Saavedra CD, Novak O, Gonçalves JT, Gage FH, Shtrahman M. PMID: 34259630; PMCID: PMC8331179.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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The Rhox gene cluster suppresses germline LINE1 transposition. Proc Natl Acad Sci U S A. 2021 06 08; 118(23).
Tan K, Kim ME, Song HW, Skarbrevik D, Babajanian E, Bedrosian TA, Gage FH, Wilkinson MF. PMID: 34083437; PMCID: PMC8201764.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho. Mol Psychiatry. 2021 11; 26(11):6365-6379.
Dias GP, Murphy T, Stangl D, Ahmet S, Morisse B, Nix A, Aimone LJ, Aimone JB, Kuro-O M, Gage FH, Thuret S. PMID: 34031536; PMCID: PMC8760057.
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PubMed Mentions:
35 Fields:
Translation:
Animals
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To eat, or not to eat, that is the question: Neural stem cells escape phagocytosis in autism with macrocephaly. Proc Natl Acad Sci U S A. 2021 05 11; 118(19).
Schafer ST, Gage FH. PMID: 33883269; PMCID: PMC8126768.
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Translation:
HumansCells
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Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients. Cell Stem Cell. 2021 09 02; 28(9):1533-1548.e6.
Mertens J, Herdy JR, Traxler L, Schafer ST, Schlachetzki JCM, Böhnke L, Reid DA, Lee H, Zangwill D, Fernandes DP, Agarwal RK, Lucciola R, Zhou-Yang L, Karbacher L, Edenhofer F, Stern S, Horvath S, Paquola ACM, Glass CK, Yuan SH, Ku M, Szücs A, Goldstein LSB, Galasko D, Gage FH. PMID: 33910058; PMCID: PMC8423435.
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PubMed Mentions:
74 Fields:
Translation:
HumansCells
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Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons. Science. 2021 04 02; 372(6537):91-94.
Reid DA, Reed PJ, Schlachetzki JCM, Nitulescu II, Chou G, Tsui EC, Jones JR, Chandran S, Lu AT, McClain CA, Ooi JH, Wang TW, Lana AJ, Linker SB, Ricciardulli AS, Lau S, Schafer ST, Horvath S, Dixon JR, Hah N, Glass CK, Gage FH. PMID: 33795458; PMCID: PMC9179101.
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PubMed Mentions:
41 Fields:
Translation:
HumansCells
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Sensing serotonin secreted from human serotonergic neurons using aptamer-modified nanopipettes. Mol Psychiatry. 2021 07; 26(7):2753-2763.
Nakatsuka N, Heard KJ, Faillétaz A, Momotenko D, Vörös J, Gage FH, Vadodaria KC. PMID: 33767349; PMCID: PMC9997689.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Circadian rhythms in bipolar disorder patient-derived neurons predict lithium response: preliminary studies. Mol Psychiatry. 2021 07; 26(7):3383-3394.
Mishra HK, Ying NM, Luis A, Wei H, Nguyen M, Nakhla T, Vandenburgh S, Alda M, Berrettini WH, Brennand KJ, Calabrese JR, Coryell WH, Frye MA, Gage FH, Gershon ES, McInnis MG, Nievergelt CM, Nurnberger JI, Shilling PD, Oedegaard KJ, Zandi PP, Pharmacogenomics of Bipolar Disorder Study, Kelsoe JR, Welsh DK, McCarthy MJ. PMID: 33674753; PMCID: PMC8418615.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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Altered Neuronal Support and Inflammatory Response in Bipolar Disorder Patient-Derived Astrocytes. Stem Cell Reports. 2021 04 13; 16(4):825-835.
Vadodaria KC, Mendes APD, Mei A, Racha V, Erikson G, Shokhirev MN, Oefner R, Heard KJ, McCarthy MJ, Eyler L, Kelsoe JR, Santos R, Marchetto MC, Gage FH. PMID: 33667413; PMCID: PMC8072028.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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The When and Where: Molecular and Cellular Convergence in Autism. Biol Psychiatry. 2021 03 01; 89(5):419-420.
Schafer ST, Gage FH. PMID: 33541523.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Cytoplasmic synthesis of endogenous Alu complementary DNA via reverse transcription and implications in age-related macular degeneration. Proc Natl Acad Sci U S A. 2021 02 09; 118(6).
Fukuda S, Varshney A, Fowler BJ, Wang SB, Narendran S, Ambati K, Yasuma T, Magagnoli J, Leung H, Hirahara S, Nagasaka Y, Yasuma R, Apicella I, Pereira F, Makin RD, Magner E, Liu X, Sun J, Wang M, Baker K, Marion KM, Huang X, Baghdasaryan E, Ambati M, Ambati VL, Pandey A, Pandya L, Cummings T, Banerjee D, Huang P, Yerramothu P, Tolstonog GV, Held U, Erwin JA, Paquola ACM, Herdy JR, Ogura Y, Terasaki H, Oshika T, Darwish S, Singh RK, Mozaffari S, Bhattarai D, Kim KB, Hardin JW, Bennett CL, Hinton DR, Hanson TE, Röver C, Parang K, Kerur N, Liu J, Werner BC, Sutton SS, Sadda SR, Schumann GG, Gelfand BD, Gage FH, Ambati J. PMID: 33526699; PMCID: PMC8017980.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Deficient LEF1 expression is associated with lithium resistance and hyperexcitability in neurons derived from bipolar disorder patients. Mol Psychiatry. 2021 06; 26(6):2440-2456.
Santos R, Linker SB, Stern S, Mendes APD, Shokhirev MN, Erikson G, Randolph-Moore L, Racha V, Kim Y, Kelsoe JR, Bang AG, Alda M, Marchetto MC, Gage FH. PMID: 33398088; PMCID: PMC9129103.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis. EMBO J. 2021 02 01; 40(3):e105819.
Bedrosian TA, Houtman J, Eguiguren JS, Ghassemzadeh S, Rund N, Novaresi NM, Hu L, Parylak SL, Denli AM, Randolph-Moore L, Namba T, Gage FH, Toda T. PMID: 33300615; PMCID: PMC7849303.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Synaptotagmin-7 deficiency induces mania-like behavioral abnormalities through attenuating GluN2B activity. Proc Natl Acad Sci U S A. 2020 12 08; 117(49):31438-31447.
Wang QW, Lu SY, Liu YN, Chen Y, Wei H, Shen W, Chen YF, Fu CL, Wang YH, Dai A, Huang X, Gage FH, Xu Q, Yao J. PMID: 33229564; PMCID: PMC7733786.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Identification of bona fide B2 SINE retrotransposon transcription through single-nucleus RNA-seq of the mouse hippocampus. Genome Res. 2020 11; 30(11):1643-1654.
Linker SB, Randolph-Moore L, Kottilil K, Qiu F, Jaeger BN, Barron J, Gage FH. PMID: 33122305; PMCID: PMC7605253.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Inositol monophosphatase 1 (IMPA1) mutation in intellectual disability patients impairs neurogenesis but not gliogenesis. Mol Psychiatry. 2021 07; 26(7):3558-3571.
Figueiredo T, Mendes APD, Moreira DP, Goulart E, Oliveira D, Kobayashi GS, Stern S, Kok F, Marchetto MC, Santos R, Gage FH, Zatz M. PMID: 32839513.
View in:
PubMed Mentions:
4 Fields:
Translation:
Humans
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Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination. J Biol Chem. 2020 08 21; 295(34):12233-12246.
Kerman BE, Genoud S, Kurt Vatandaslar B, Denli AM, Georges Ghosh S, Xu X, Yeo GW, Aimone JB, Gage FH. PMID: 32647008; PMCID: PMC7443494.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Cellular complexity in brain organoids: Current progress and unsolved issues. Semin Cell Dev Biol. 2021 03; 111:32-39.
Mansour AA, Schafer ST, Gage FH. PMID: 32499191.
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PubMed Mentions:
23 Fields:
Translation:
HumansCells
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Modeling Brain Disorders Using Induced Pluripotent Stem Cells. Cold Spring Harb Perspect Biol. 2020 06 01; 12(6).
Vadodaria KC, Jones JR, Linker S, Gage FH. PMID: 31767646; PMCID: PMC7263088.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Loss of the neural-specific BAF subunit ACTL6B relieves repression of early response genes and causes recessive autism. Proc Natl Acad Sci U S A. 2020 05 05; 117(18):10055-10066.
Wenderski W, Wang L, Krokhotin A, Walsh JJ, Li H, Shoji H, Ghosh S, George RD, Miller EL, Elias L, Gillespie MA, Son EY, Staahl BT, Baek ST, Stanley V, Moncada C, Shipony Z, Linker SB, Marchetto MCN, Gage FH, Chen D, Sultan T, Zaki MS, Ranish JA, Miyakawa T, Luo L, Malenka RC, Crabtree GR, Gleeson JG. PMID: 32312822; PMCID: PMC7211998.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Modeling Human Cytomegalovirus-Induced Microcephaly in Human iPSC-Derived Brain Organoids. Cell Rep Med. 2020 04 21; 1(1):100002.
Sun G, Chiuppesi F, Chen X, Wang C, Tian E, Nguyen J, Kha M, Trinh D, Zhang H, Marchetto MC, Song H, Ming GL, Gage FH, Diamond DJ, Wussow F, Shi Y. PMID: 33205055; PMCID: PMC7659592.
View in:
PubMed Mentions:
51 Fields:
Translation:
HumansCells
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Author Correction: Conversion of human fibroblasts to angioblast-like progenitor cells. Nat Methods. 2020 03; 17(3):353.
Kurian L, Sancho-Martinez I, Nivet E, Aguirre A, Moon K, Pendaries C, Volle-Challier C, Bono F, Herbert JM, Pulecio J, Xia Y, Li M, Montserrat N, Ruiz S, Dubova I, Rodriguez C, Denli AM, Boscolo FS, Thiagarajan RD, Gage FH, Loring JF, Laurent LC, Belmonte JCI. PMID: 32034376.
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PubMed Mentions: Fields:
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Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice. Proc Natl Acad Sci U S A. 2020 02 25; 117(8):4392-4399.
Shen W, Wang QW, Liu YN, Marchetto MC, Linker S, Lu SY, Chen Y, Liu C, Guo C, Xing Z, Shi W, Kelsoe JR, Alda M, Wang H, Zhong Y, Sui SF, Zhao M, Yang Y, Mi S, Cao L, Gage FH, Yao J. PMID: 32041882; PMCID: PMC7049155.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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A Physiological Instability Displayed in Hippocampal Neurons Derived From Lithium-Nonresponsive Bipolar Disorder Patients. Biol Psychiatry. 2020 07 15; 88(2):150-158.
Stern S, Sarkar A, Galor D, Stern T, Mei A, Stern Y, Mendes APD, Randolph-Moore L, Rouleau G, Bang AG, Santos R, Alda M, Marchetto MC, Gage FH. PMID: 32278494; PMCID: PMC10871148.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability. Cell Stem Cell. 2020 02 06; 26(2):221-233.e6.
Wang M, Wei PC, Lim CK, Gallina IS, Marshall S, Marchetto MC, Alt FW, Gage FH. PMID: 32004479; PMCID: PMC7175642.
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PubMed Mentions:
39 Fields:
Translation:
HumansCells
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Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis. Cell Stem Cell. 2020 02 06; 26(2):187-204.e10.
Zhu Z, Mesci P, Bernatchez JA, Gimple RC, Wang X, Schafer ST, Wettersten HI, Beck S, Clark AE, Wu Q, Prager BC, Kim LJY, Dhanwani R, Sharma S, Garancher A, Weis SM, Mack SC, Negraes PD, Trujillo CA, Penalva LO, Feng J, Lan Z, Zhang R, Wessel AW, Dhawan S, Diamond MS, Chen CC, Wechsler-Reya RJ, Gage FH, Hu H, Siqueira-Neto JL, Muotri AR, Cheresh DA, Rich JN. PMID: 31956038; PMCID: PMC9628766.
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PubMed Mentions:
90 Fields:
Translation:
HumansCells
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Brain cell type-specific enhancer-promoter interactome maps and disease-risk association. Science. 2019 11 29; 366(6469):1134-1139.
Nott A, Holtman IR, Coufal NG, Schlachetzki JCM, Yu M, Hu R, Han CZ, Pena M, Xiao J, Wu Y, Keulen Z, Pasillas MP, O'Connor C, Nickl CK, Schafer ST, Shen Z, Rissman RA, Brewer JB, Gosselin D, Gonda DD, Levy ML, Rosenfeld MG, McVicker G, Gage FH, Ren B, Glass CK. PMID: 31727856; PMCID: PMC7028213.
View in:
PubMed Mentions:
276 Fields:
Translation:
HumansCells
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Mechanisms Underlying the Hyperexcitability of CA3 and Dentate Gyrus Hippocampal Neurons Derived From Patients With Bipolar Disorder. Biol Psychiatry. 2020 07 15; 88(2):139-149.
Stern S, Sarkar A, Stern T, Mei A, Mendes APD, Stern Y, Goldberg G, Galor D, Nguyen T, Randolph-Moore L, Kim Y, Rouleau G, Bang A, Alda M, Santos R, Marchetto MC, Gage FH. PMID: 31732108; PMCID: PMC7108962.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Dynamical Electrical Complexity Is Reduced during Neuronal Differentiation in Autism Spectrum Disorder. Stem Cell Reports. 2019 09 10; 13(3):474-484.
Amatya DN, Linker SB, Mendes APD, Santos R, Erikson G, Shokhirev MN, Zhou Y, Sharpee T, Gage FH, Marchetto MC, Kim Y. PMID: 31474529; PMCID: PMC6739708.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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An Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack KNa Currents. J Neurosci. 2019 09 11; 39(37):7438-7449.
Quraishi IH, Stern S, Mangan KP, Zhang Y, Ali SR, Mercier MR, Marchetto MC, McLachlan MJ, Jones EM, Gage FH, Kaczmarek LK. PMID: 31350261; PMCID: PMC6759030.
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PubMed Mentions:
40 Fields:
Translation:
HumansCells
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Prediction of Response to Drug Therapy in Psychiatric Disorders. Focus (Am Psychiatr Publ). 2019 Jul; 17(3):294-307.
Stern S, Linker S, Vadodaria KC, Marchetto MC, Gage FH. PMID: 32015721; PMCID: PMC6996058.
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PubMed Mentions:
3
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Corrigendum: Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells. Front Mol Neurosci. 2019; 12:150.
van den Hurk M, Erwin JA, Yeo GW, Gage FH, Bardy C. PMID: 31244603; PMCID: PMC6580186.
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PubMed Mentions:
2
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Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease. Cell Stem Cell. 2019 Jun 06; 24(6):1006.
Sommer A, Marxreiter F, Krach F, Fadler T, Grosch J, Maroni M, Graef D, Eberhardt E, Riemenschneider MJ, Yeo GW, Kohl Z, Xiang W, Gage FH, Winkler J, Prots I, Winner B. PMID: 31173705.
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PubMed Mentions:
15 Fields:
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Adult neurogenesis in mammals. Science. 2019 May 31; 364(6443):827-828.
Gage FH. PMID: 31147506.
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PubMed Mentions:
99 Fields:
Translation:
HumansAnimalsCells
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Modeling neuropsychiatric disorders using human induced pluripotent stem cells. Protein Cell. 2020 01; 11(1):45-59.
Wang M, Zhang L, Gage FH. PMID: 31134525; PMCID: PMC6949328.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
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Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons. Elife. 2019 05 17; 8.
Herdy J, Schafer S, Kim Y, Ansari Z, Zangwill D, Ku M, Paquola A, Lee H, Mertens J, Gage FH. PMID: 31099332; PMCID: PMC6524968.
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PubMed Mentions:
26 Fields:
Translation:
HumansCells
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Nerve cells from the brain invade prostate tumours. Nature. 2019 05; 569(7758):637-638.
Schafer ST, Gage FH. PMID: 31138915.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Entrainment of Circadian Rhythms to Temperature Reveals Amplitude Deficits in Fibroblasts from Patients with Bipolar Disorder and Possible Links to Calcium Channels. Mol Neuropsychiatry. 2019 Apr; 5(2):115-124.
Nudell V, Wei H, Nievergelt C, Maihofer AX, Shilling P, Alda M, Berrettini WH, Brennand KJ, Calabrese JR, Coryell WH, Covault JM, Frye MA, Gage F, Gershon E, McInnis MG, Nurnberger JI, Oedegaard KJ, Shekhtman T, Zandi PP, Kelsoe JR, McCarthy MJ. PMID: 31192224; PMCID: PMC6528084.
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PubMed Mentions:
8
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Altered serotonergic circuitry in SSRI-resistant major depressive disorder patient-derived neurons. Mol Psychiatry. 2019 06; 24(6):808-818.
Vadodaria KC, Ji Y, Skime M, Paquola AC, Nelson T, Hall-Flavin D, Heard KJ, Fredlender C, Deng Y, Elkins J, Dani K, Le AT, Marchetto MC, Weinshilboum R, Gage FH. PMID: 30903001; PMCID: PMC7409972.
View in:
PubMed Mentions:
40 Fields:
Translation:
HumansCells
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Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. Nature. 2019 03; 567(7749):535-539.
Farrelly LA, Thompson RE, Zhao S, Lepack AE, Lyu Y, Bhanu NV, Zhang B, Loh YE, Ramakrishnan A, Vadodaria KC, Heard KJ, Erikson G, Nakadai T, Bastle RM, Lukasak BJ, Zebroski H, Alenina N, Bader M, Berton O, Roeder RG, Molina H, Gage FH, Shen L, Garcia BA, Li H, Muir TW, Maze I. PMID: 30867594; PMCID: PMC6557285.
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PubMed Mentions:
163 Fields:
Translation:
HumansAnimalsCells
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Microglia, complement and schizophrenia. Nat Neurosci. 2019 03; 22(3):333-334.
Wang M, Zhang L, Gage FH. PMID: 30796420.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Species-specific maturation profiles of human, chimpanzee and bonobo neural cells. Elife. 2019 02 07; 8.
Marchetto MC, Hrvoj-Mihic B, Kerman BE, Yu DX, Vadodaria KC, Linker SB, Narvaiza I, Santos R, Denli AM, Mendes AP, Oefner R, Cook J, McHenry L, Grasmick JM, Heard K, Fredlender C, Randolph-Moore L, Kshirsagar R, Xenitopoulos R, Chou G, Hah N, Muotri AR, Padmanabhan K, Semendeferi K, Gage FH. PMID: 30730291; PMCID: PMC6366899.
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PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
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Mitochondria, Metabolism, and Redox Mechanisms in Psychiatric Disorders. Antioxid Redox Signal. 2019 08 01; 31(4):275-317.
Kim Y, Vadodaria KC, Lenkei Z, Kato T, Gage FH, Marchetto MC, Santos R. PMID: 30585734; PMCID: PMC6602118.
View in:
PubMed Mentions:
69 Fields:
Translation:
HumansAnimalsCells
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Serotonin-induced hyperactivity in SSRI-resistant major depressive disorder patient-derived neurons. Mol Psychiatry. 2019 06; 24(6):795-807.
Vadodaria KC, Ji Y, Skime M, Paquola A, Nelson T, Hall-Flavin D, Fredlender C, Heard KJ, Deng Y, Le AT, Dave S, Fung L, Li X, Marchetto MC, Weinshilboum R, Gage FH. PMID: 30700803.
View in:
PubMed Mentions:
32 Fields:
Translation:
HumansCells
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Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 2019 Jan 16; 101(2):349.
Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, Corjuc BT, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Mertens J, Troncoso J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman BT. PMID: 30653936; PMCID: PMC6377243.
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PubMed Mentions:
11 Fields:
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BrainImageR: spatiotemporal gene set analysis referencing the human brain. Bioinformatics. 2019 01 15; 35(2):343-345.
Linker SB, Hsu JY, Pfaff A, Amatya D, Ko SM, Voter S, Wong Q, Gage FH. PMID: 30010719; PMCID: PMC6657270.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Limits to human neurogenesis-really? Mol Psychiatry. 2020 10; 25(10):2207-2209.
Lucassen PJ, Toni N, Kempermann G, Frisen J, Gage FH, Swaab DF. PMID: 30617274; PMCID: PMC7515796.
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PubMed Mentions:
27 Fields:
Translation:
Humans
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Centrifugal Inputs to the Main Olfactory Bulb Revealed Through Whole Brain Circuit-Mapping. Front Neuroanat. 2018; 12:115.
Padmanabhan K, Osakada F, Tarabrina A, Kizer E, Callaway EM, Gage FH, Sejnowski TJ. PMID: 30666191; PMCID: PMC6330333.
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PubMed Mentions:
29
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Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons. Nat Neurosci. 2019 02; 22(2):243-255.
Schafer ST, Paquola ACM, Stern S, Gosselin D, Ku M, Pena M, Kuret TJM, Liyanage M, Mansour AA, Jaeger BN, Marchetto MC, Glass CK, Mertens J, Gage FH. PMID: 30617258; PMCID: PMC6402576.
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PubMed Mentions:
114 Fields:
Translation:
HumansCells
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Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder. Neuropsychopharmacology. 2019 02; 44(3):620-628.
McCarthy MJ, Wei H, Nievergelt CM, Stautland A, Maihofer AX, Welsh DK, Shilling P, Alda M, Alliey-Rodriguez N, Anand A, Andreasson OA, Balaraman Y, Berrettini WH, Bertram H, Brennand KJ, Calabrese JR, Calkin CV, Claasen A, Conroy C, Coryell WH, Craig DW, D'Arcangelo N, Demodena A, Djurovic S, Feeder S, Fisher C, Frazier N, Frye MA, Gage FH, Gao K, Garnham J, Gershon ES, Glazer K, Goes F, Goto T, Harrington G, Jakobsen P, Kamali M, Karberg E, Kelly M, Leckband SG, Lohoff F, McInnis MG, Mondimore F, Morken G, Nurnberger JI, Obral S, Oedegaard KJ, Ortiz A, Ritchey M, Ryan K, Schinagle M, Schoeyen H, Schwebel C, Shaw M, Shekhtman T, Slaney C, Stapp E, Szelinger S, Tarwater B, Zandi PP, Kelsoe JR. PMID: 30487653; PMCID: PMC6333516.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Long-Term Labeling of Hippocampal Neural Stem Cells by a Lentiviral Vector. Front Mol Neurosci. 2018; 11:415.
Suh H, Zhou QG, Fernandez-Carasa I, Clemenson GD, Pons-Espinal M, Ro EJ, Marti M, Raya A, Gage FH, Consiglio A. PMID: 30498432; PMCID: PMC6249367.
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PubMed Mentions:
3
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Adult Hippocampal Neurogenesis: A Coming-of-Age Story. J Neurosci. 2018 12 05; 38(49):10401-10410.
Kuhn HG, Toda T, Gage FH. PMID: 30381404; PMCID: PMC6284110.
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PubMed Mentions:
78 Fields:
Translation:
HumansAnimals
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Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases. Annu Rev Genet. 2018 11 23; 52:271-293.
Mertens J, Reid D, Lau S, Kim Y, Gage FH. PMID: 30208291; PMCID: PMC6415910.
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PubMed Mentions:
131 Fields:
Translation:
HumansCells
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Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model. Science. 2018 09 07; 361(6406).
Choi SH, Bylykbashi E, Chatila ZK, Lee SW, Pulli B, Clemenson GD, Kim E, Rompala A, Oram MK, Asselin C, Aronson J, Zhang C, Miller SJ, Lesinski A, Chen JW, Kim DY, van Praag H, Spiegelman BM, Gage FH, Tanzi RE. PMID: 30190379; PMCID: PMC6149542.
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PubMed Mentions:
299 Fields:
Translation:
HumansAnimals
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Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 2018 09 05; 99(5):925-940.e7.
Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, Corjuc BT, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Mertens J, Troncoso J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman BT. PMID: 30189209; PMCID: PMC6240334.
View in:
PubMed Mentions:
181 Fields:
Translation:
HumansAnimalsCells
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Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells. Front Mol Neurosci. 2018; 11:261.
van den Hurk M, Erwin JA, Yeo GW, Gage FH, Bardy C. PMID: 30147644; PMCID: PMC6096303.
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PubMed Mentions:
23
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A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons. Nat Commun. 2018 08 06; 9(1):3084.
Jaeger BN, Linker SB, Parylak SL, Barron JJ, Gallina IS, Saavedra CD, Fitzpatrick C, Lim CK, Schafer ST, Lacar B, Jessberger S, Gage FH. PMID: 30082781; PMCID: PMC6079101.
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PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
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Erratum: An in vivo model of functional and vascularized human brain organoids. Nat Biotechnol. 2018 08 06; 36(8):772.
Mansour AA, Gonçalves JT, Bloyd CW, Li H, Fernandes S, Quang D, Johnston S, Parylak SL, Jin X, Gage FH. PMID: 30080830.
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PubMed Mentions:
7 Fields:
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Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease. Cell Stem Cell. 2018 Jul 05; 23(1):123-131.e6.
Sommer A, Marxreiter F, Krach F, Fadler T, Grosch J, Maroni M, Graef D, Eberhardt E, Riemenschneider MJ, Yeo GW, Kohl Z, Xiang W, Gage FH, Winkler J, Prots I, Winner B. PMID: 29979986.
View in:
PubMed Mentions:
136 Fields:
Translation:
HumansCells
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Author Correction: L1-associated genomic regions are deleted in somatic cells of the healthy human brain. Nat Neurosci. 2018 Jul; 21(7):1016.
Erwin JA, Paquola ACM, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FIA, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage FH. PMID: 29703932.
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PubMed Mentions:
2 Fields:
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Author Correction: CRISPR interference-based specific and efficient gene inactivation in the brain. Nat Neurosci. 2018 Jun; 21(6):894.
Zheng Y, Shen W, Zhang J, Yang B, Liu YN, Qi H, Yu X, Lu SY, Chen Y, Xu YZ, Li Y, Gage FH, Mi S, Yao J. PMID: 29545585.
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PubMed Mentions:
6 Fields:
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Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile. Cell Rep. 2018 05 29; 23(9):2550-2558.
Kim Y, Zheng X, Ansari Z, Bunnell MC, Herdy JR, Traxler L, Lee H, Paquola ACM, Blithikioti C, Ku M, Schlachetzki JCM, Winkler J, Edenhofer F, Glass CK, Paucar AA, Jaeger BN, Pham S, Boyer L, Campbell BC, Hunter T, Mertens J, Gage FH. PMID: 29847787; PMCID: PMC6478017.
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PubMed Mentions:
55 Fields:
Translation:
HumansCells
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Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs. Sci Transl Med. 2018 05 09; 10(440).
Strnadel J, Carromeu C, Bardy C, Navarro M, Platoshyn O, Glud AN, Marsala S, Kafka J, Miyanohara A, Kato T, Tadokoro T, Hefferan MP, Kamizato K, Yoshizumi T, Juhas S, Juhasova J, Ho CS, Kheradmand T, Chen P, Bohaciakova D, Hruska-Plochan M, Todd AJ, Driscoll SP, Glenn TD, Pfaff SL, Klima J, Ciacci J, Curtis E, Gage FH, Bui J, Yamada K, Muotri AR, Marsala M. PMID: 29743351.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro. Cell Stem Cell. 2018 05 03; 22(5):684-697.e9.
Sarkar A, Mei A, Paquola ACM, Stern S, Bardy C, Klug JR, Kim S, Neshat N, Kim HJ, Ku M, Shokhirev MN, Adamowicz DH, Marchetto MC, Jappelli R, Erwin JA, Padmanabhan K, Shtrahman M, Jin X, Gage FH. PMID: 29727680; PMCID: PMC6345574.
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PubMed Mentions:
61 Fields:
Translation:
HumansAnimalsCells
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Prediction of response to drug therapy in psychiatric disorders. Open Biol. 2018 05; 8(5).
Stern S, Linker S, Vadodaria KC, Marchetto MC, Gage FH. PMID: 29794033; PMCID: PMC5990649.
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PubMed Mentions:
22 Fields:
Translation:
Humans
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The role of adult hippocampal neurogenesis in brain health and disease. Mol Psychiatry. 2019 01; 24(1):67-87.
Toda T, Parylak SL, Linker SB, Gage FH. PMID: 29679070; PMCID: PMC6195869.
View in:
PubMed Mentions:
249 Fields:
Translation:
HumansCells
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Human Adult Neurogenesis: Evidence and Remaining Questions. Cell Stem Cell. 2018 Jul 05; 23(1):25-30.
Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, Kuhn HG, Jessberger S, Frankland PW, Cameron HA, Gould E, Hen R, Abrous DN, Toni N, Schinder AF, Zhao X, Lucassen PJ, Frisén J. PMID: 29681514; PMCID: PMC6035081.
View in:
PubMed Mentions:
328 Fields:
Translation:
HumansCells
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An in vivo model of functional and vascularized human brain organoids. Nat Biotechnol. 2018 06; 36(5):432-441.
Mansour AA, Gonçalves JT, Bloyd CW, Li H, Fernandes S, Quang D, Johnston S, Parylak SL, Jin X, Gage FH. PMID: 29658944; PMCID: PMC6331203.
View in:
PubMed Mentions:
479 Fields:
Translation:
HumansAnimalsCells
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Early life experience drives structural variation of neural genomes in mice. Science. 2018 03 23; 359(6382):1395-1399.
Bedrosian TA, Quayle C, Novaresi N, Gage FH. PMID: 29567711.
View in:
PubMed Mentions:
51 Fields:
Translation:
AnimalsCells
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CRISPR interference-based specific and efficient gene inactivation in the brain. Nat Neurosci. 2018 03; 21(3):447-454.
Zheng Y, Shen W, Zhang J, Yang B, Liu YN, Qi H, Yu X, Lu SY, Chen Y, Xu YZ, Li Y, Gage FH, Mi S, Yao J. PMID: 29403034.
View in:
PubMed Mentions:
76 Fields:
Translation:
Animals
-
Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward. Genome Med. 2018 01 04; 10(1):1.
Vadodaria KC, Amatya DN, Marchetto MC, Gage FH. PMID: 29301565; PMCID: PMC5755287.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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MicroRNAs in Post-traumatic Stress Disorder. Curr Top Behav Neurosci. 2018; 38:23-46.
Snijders C, de Nijs L, Baker DG, Hauger RL, van den Hove D, Kenis G, Nievergelt CM, Boks MP, Vermetten E, Gage FH, Rutten BPF. PMID: 29063484.
View in:
PubMed Mentions:
11 Fields:
Translation:
Animals
-
Review: adult neurogenesis contributes to hippocampal plasticity. Cell Tissue Res. 2018 Sep; 373(3):693-709.
Toda T, Gage FH. PMID: 29185071.
View in:
PubMed Mentions:
108 Fields:
Translation:
HumansAnimalsCells
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Mechanisms of dietary flavonoid action in neuronal function and neuroinflammation. Mol Aspects Med. 2018 06; 61:50-62.
Jaeger BN, Parylak SL, Gage FH. PMID: 29117513.
View in:
PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Corrigendum: L1-associated genomic regions are deleted in somatic cells of the healthy human brain. Nat Neurosci. 2017 Sep 28; 20(10):1427.
Erwin JA, Paquola ACM, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FIA, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage FH. PMID: 28949329.
View in:
PubMed Mentions: Fields:
-
An in vitro model of lissencephaly: expanding the role of DCX during neurogenesis. Mol Psychiatry. 2018 07; 23(7):1674-1684.
Shahsavani M, Pronk RJ, Falk R, Lam M, Moslem M, Linker SB, Salma J, Day K, Schuster J, Anderlid BM, Dahl N, Gage FH, Falk A. PMID: 28924182.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansCells
-
Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells. Cell Stem Cell. 2017 Nov 02; 21(5):618-634.e7.
Toda T, Hsu JY, Linker SB, Hu L, Schafer ST, Mertens J, Jacinto FV, Hetzer MW, Gage FH. PMID: 28919367.
View in:
PubMed Mentions:
61 Fields:
Translation:
AnimalsCells
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Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells. Cell Rep. 2017 09 05; 20(10):2525.
Topol A, Zhu S, Hartley BJ, English J, Hauberg ME, Tran N, Rittenhouse CA, Simone A, Ruderfer DM, Johnson J, Readhead B, Hadas Y, Gochman PA, Wang YC, Shah H, Cagney G, Rapoport J, Gage FH, Dudley JT, Sklar P, Mattheisen M, Cotter D, Fang G, Brennand KJ. PMID: 28877483; PMCID: PMC5599129.
View in:
PubMed Mentions:
5 Fields:
-
Serotonin in psychiatry: in vitro disease modeling using patient-derived neurons. Cell Tissue Res. 2018 01; 371(1):161-170.
Vadodaria KC, Stern S, Marchetto MC, Gage FH. PMID: 28812143.
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Examining non-LTR retrotransposons in the context of the evolving primate brain. BMC Biol. 2017 08 11; 15(1):68.
Linker SB, Marchetto MC, Narvaiza I, Denli AM, Gage FH. PMID: 28800766; PMCID: PMC5554003.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Intact piRNA pathway prevents L1 mobilization in male meiosis. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):E5635-E5644.
Newkirk SJ, Lee S, Grandi FC, Gaysinskaya V, Rosser JM, Vanden Berg N, Hogarth CA, Marchetto MCN, Muotri AR, Griswold MD, Ye P, Bortvin A, Gage FH, Boeke JD, An W. PMID: 28630288; PMCID: PMC5514719.
View in:
PubMed Mentions:
50 Fields:
Translation:
AnimalsCells
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Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 06 06; 8(6):1757-1769.
Santos R, Vadodaria KC, Jaeger BN, Mei A, Lefcochilos-Fogelquist S, Mendes APD, Erikson G, Shokhirev M, Randolph-Moore L, Fredlender C, Dave S, Oefner R, Fitzpatrick C, Pena M, Barron JJ, Ku M, Denli AM, Kerman BE, Charnay P, Kelsoe JR, Marchetto MC, Gage FH. PMID: 28591655; PMCID: PMC5470172.
View in:
PubMed Mentions:
66 Fields:
Translation:
HumansCells
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An environment-dependent transcriptional network specifies human microglia identity. Science. 2017 06 23; 356(6344).
Gosselin D, Skola D, Coufal NG, Holtman IR, Schlachetzki JCM, Sajti E, Jaeger BN, O'Connor C, Fitzpatrick C, Pasillas MP, Pena M, Adair A, Gonda DD, Levy ML, Ransohoff RM, Gage FH, Glass CK. PMID: 28546318; PMCID: PMC5858585.
View in:
PubMed Mentions:
493 Fields:
Translation:
HumansAnimalsCells
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Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling. Nat Commun. 2017 05 02; 8:15157.
Ishii S, Torii M, Son AI, Rajendraprasad M, Morozov YM, Kawasawa YI, Salzberg AC, Fujimoto M, Brennand K, Nakai A, Mezger V, Gage FH, Rakic P, Hashimoto-Torii K. PMID: 28462912; PMCID: PMC5418582.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network. Science. 2017 04 28; 356(6336).
McConnell MJ, Moran JV, Abyzov A, Akbarian S, Bae T, Cortes-Ciriano I, Erwin JA, Fasching L, Flasch DA, Freed D, Ganz J, Jaffe AE, Kwan KY, Kwon M, Lodato MA, Mills RE, Paquola ACM, Rodin RE, Rosenbluh C, Sestan N, Sherman MA, Shin JH, Song S, Straub RE, Thorpe J, Weinberger DR, Urban AE, Zhou B, Gage FH, Lehner T, Senthil G, Walsh CA, Chess A, Courchesne E, Gleeson JG, Kidd JM, Park PJ, Pevsner J, Vaccarino FM, Brain Somatic Mosaicism Network. PMID: 28450582; PMCID: PMC5558435.
View in:
PubMed Mentions:
114 Fields:
Translation:
HumansCells
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Corrigendum: Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes Dev. 2017 04 15; 31(8):845.
Franks TM, Benner C, Narvaiza I, Marchetto MCN, Young JM, Malik HS, Gage FH, Hetzer MW. PMID: 28512238; PMCID: PMC5435895.
View in:
PubMed Mentions: Fields:
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Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation. Nat Commun. 2017 03 17; 8:15047.
Lacar B, Linker SB, Jaeger BN, Krishnaswami SR, Barron JJ, Kelder MJ, Parylak SL, Paquola AC, Venepally P, Novotny M, O'Connor C, Fitzpatrick C, Erwin JA, Hsu JY, Husband D, McConnell MJ, Lasken R, Gage FH. PMID: 28303884; PMCID: PMC5357833.
View in:
PubMed Mentions:
1 Fields:
-
Conserved expression of transposon-derived non-coding transcripts in primate stem cells. BMC Genomics. 2017 02 28; 18(1):214.
Ramsay L, Marchetto MC, Caron M, Chen SH, Busche S, Kwan T, Pastinen T, Gage FH, Bourque G. PMID: 28245871; PMCID: PMC5331655.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients' responsiveness to lithium. Mol Psychiatry. 2018 06; 23(6):1453-1465.
Stern S, Santos R, Marchetto MC, Mendes APD, Rouleau GA, Biesmans S, Wang QW, Yao J, Charnay P, Bang AG, Alda M, Gage FH. PMID: 28242870; PMCID: PMC5573640.
View in:
PubMed Mentions:
68 Fields:
Translation:
HumansCells
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Molecular Mechanisms of Bipolar Disorder: Progress Made and Future Challenges. Front Cell Neurosci. 2017; 11:30.
Kim Y, Santos R, Gage FH, Marchetto MC. PMID: 28261061; PMCID: PMC5306135.
View in:
PubMed Mentions:
35
-
Hippocampal α-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology. J Neurosci. 2017 02 15; 37(7):1675-1684.
Adamowicz DH, Roy S, Salmon DP, Galasko DR, Hansen LA, Masliah E, Gage FH. PMID: 28039370; PMCID: PMC5320602.
View in:
PubMed Mentions:
57 Fields:
Translation:
Humans
-
Insights into the role of somatic mosaicism in the brain. Curr Opin Syst Biol. 2017 Feb; 1:90-94.
Paquola ACM, Erwin JA, Gage FH. PMID: 29226270; PMCID: PMC5718369.
View in:
PubMed Mentions:
22
-
A role for miR-19 in the migration of adult-born neurons and schizophrenia. Neurogenesis (Austin). 2016; 3(1):e1251873.
Han J, Gage FH. PMID: 28405585; PMCID: PMC5384614.
View in:
PubMed Mentions:
6
-
Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior. Cell. 2016 Nov 03; 167(4):897-914.
Gonçalves JT, Schafer ST, Gage FH. PMID: 27814520.
View in:
PubMed Mentions:
459 Fields:
Translation:
HumansAnimalsCells
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Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology. Mol Psychiatry. 2016 11; 21(11):1573-1588.
Bardy C, van den Hurk M, Kakaradov B, Erwin JA, Jaeger BN, Hernandez RV, Eames T, Paucar AA, Gorris M, Marchand C, Jappelli R, Barron J, Bryant AK, Kellogg M, Lasken RS, Rutten BP, Steinbusch HW, Yeo GW, Gage FH. PMID: 27698428; PMCID: PMC5071135.
View in:
PubMed Mentions:
78 Fields:
Translation:
HumansCells
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Generating human serotonergic neurons in vitro: Methodological advances. Bioessays. 2016 11; 38(11):1123-1129.
Vadodaria KC, Marchetto MC, Mertens J, Gage FH. PMID: 27716980.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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L1-associated genomic regions are deleted in somatic cells of the healthy human brain. Nat Neurosci. 2016 12; 19(12):1583-1591.
Erwin JA, Paquola AC, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FI, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage FH. PMID: 27618310; PMCID: PMC5127747.
View in:
PubMed Mentions:
91 Fields:
Translation:
HumansCells
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Dopaminergic inputs in the dentate gyrus direct the choice of memory encoding. Proc Natl Acad Sci U S A. 2016 09 13; 113(37):E5501-10.
Du H, Deng W, Aimone JB, Ge M, Parylak S, Walch K, Zhang W, Cook J, Song H, Wang L, Gage FH, Mu Y. PMID: 27573822; PMCID: PMC5027420.
View in:
PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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A human neurodevelopmental model for Williams syndrome. Nature. 2016 08 18; 536(7616):338-43.
Chailangkarn T, Trujillo CA, Freitas BC, Hrvoj-Mihic B, Herai RH, Yu DX, Brown TT, Marchetto MC, Bardy C, McHenry L, Stefanacci L, Järvinen A, Searcy YM, DeWitt M, Wong W, Lai P, Ard MC, Hanson KL, Romero S, Jacobs B, Dale AM, Dai L, Korenberg JR, Gage FH, Bellugi U, Halgren E, Semendeferi K, Muotri AR. PMID: 27509850; PMCID: PMC4995142.
View in:
PubMed Mentions:
90 Fields:
Translation:
HumansCells
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Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility. Nature. 2016 08 11; 536(7615):205-9.
Nuttle X, Giannuzzi G, Duyzend MH, Schraiber JG, Narvaiza I, Sudmant PH, Penn O, Chiatante G, Malig M, Huddleston J, Benner C, Camponeschi F, Ciofi-Baffoni S, Stessman HA, Marchetto MC, Denman L, Harshman L, Baker C, Raja A, Penewit K, Janke N, Tang WJ, Ventura M, Banci L, Antonacci F, Akey JM, Amemiya CT, Gage FH, Reymond A, Eichler EE. PMID: 27487209; PMCID: PMC4988886.
View in:
PubMed Mentions:
61 Fields:
Translation:
HumansAnimalsCells
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Transcriptional and epigenetic mechanisms of cellular reprogramming to induced pluripotency. Epigenomics. 2016 08; 8(8):1131-49.
van den Hurk M, Kenis G, Bardy C, van den Hove DL, Gage FH, Steinbusch HW, Rutten BP. PMID: 27419933; PMCID: PMC5514980.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Diverse Representations of Olfactory Information in Centrifugal Feedback Projections. J Neurosci. 2016 07 13; 36(28):7535-45.
Padmanabhan K, Osakada F, Tarabrina A, Kizer E, Callaway EM, Gage FH, Sejnowski TJ. PMID: 27413162; PMCID: PMC4945671.
View in:
PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Functional Implications of miR-19 in the Migration of Newborn Neurons in the Adult Brain. Neuron. 2016 07 06; 91(1):79-89.
Han J, Kim HJ, Schafer ST, Paquola A, Clemenson GD, Toda T, Oh J, Pankonin AR, Lee BS, Johnston ST, Sarkar A, Denli AM, Gage FH. PMID: 27387650.
View in:
PubMed Mentions:
49 Fields:
Translation:
HumansAnimalsCells
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Altered proliferation and networks in neural cells derived from idiopathic autistic individuals. Mol Psychiatry. 2017 06; 22(6):820-835.
Marchetto MC, Belinson H, Tian Y, Freitas BC, Fu C, Vadodaria K, Beltrao-Braga P, Trujillo CA, Mendes APD, Padmanabhan K, Nunez Y, Ou J, Ghosh H, Wright R, Brennand K, Pierce K, Eichenfield L, Pramparo T, Eyler L, Barnes CC, Courchesne E, Geschwind DH, Gage FH, Wynshaw-Boris A, Muotri AR. PMID: 27378147; PMCID: PMC5215991.
View in:
PubMed Mentions:
201 Fields:
Translation:
HumansCells
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Aging and Rejuvenation: Insights from Rusty Gage, Leonard Guarente, and Amy Wagers. Trends Mol Med. 2016 08; 22(8):633-634.
Gage FH, Guarente LP, Wagers AJ. PMID: 27396512.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
-
Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation. Nat Commun. 2016 06 14; 7:12020.
Lacar B, Linker SB, Jaeger BN, Krishnaswami SR, Barron JJ, Kelder MJ, Parylak SL, Paquola AC, Venepally P, Novotny M, O'Connor C, Fitzpatrick C, Erwin JA, Hsu JY, Husband D, McConnell MJ, Lasken R, Gage FH. PMID: 27295945; PMCID: PMC4911670.
View in:
PubMed Mentions:
1 Fields:
-
Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation. Elife. 2016 06 10; 5.
Zheng X, Boyer L, Jin M, Mertens J, Kim Y, Ma L, Ma L, Hamm M, Gage FH, Hunter T. PMID: 27282387; PMCID: PMC4963198.
View in:
PubMed Mentions:
277 Fields:
Translation:
HumansCells
-
Environment-driven somatic mosaicism in brain disorders. Genome Med. 2016 05 23; 8(1):58.
Bedrosian TA, Linker S, Gage FH. PMID: 27215330; PMCID: PMC4877941.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
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What is memory? The present state of the engram. BMC Biol. 2016 05 19; 14:40.
Poo MM, Pignatelli M, Ryan TJ, Tonegawa S, Bonhoeffer T, Martin KC, Rudenko A, Tsai LH, Tsien RW, Fishell G, Mullins C, Gonçalves JT, Shtrahman M, Johnston ST, Gage FH, Dan Y, Long J, Buzsáki G, Stevens C. PMID: 27197636; PMCID: PMC4874022.
View in:
PubMed Mentions:
122 Fields:
Translation:
HumansAnimalsCells
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Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience. Nat Rev Neurosci. 2016 07; 17(7):424-37.
Mertens J, Marchetto MC, Bardy C, Gage FH. PMID: 27194476; PMCID: PMC6276815.
View in:
PubMed Mentions:
139 Fields:
Translation:
HumansAnimalsCells
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Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes Dev. 2016 05 15; 30(10):1155-71.
Franks TM, Benner C, Narvaiza I, Marchetto MC, Young JM, Malik HS, Gage FH, Hetzer MW. PMID: 27198230; PMCID: PMC4888837.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansCells
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The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample. BMC Psychiatry. 2016 May 05; 16:129.
Oedegaard KJ, Alda M, Anand A, Andreassen OA, Balaraman Y, Berrettini WH, Bhattacharjee A, Brennand KJ, Burdick KE, Calabrese JR, Calkin CV, Claasen A, Coryell WH, Craig D, DeModena A, Frye M, Gage FH, Gao K, Garnham J, Gershon E, Jakobsen P, Leckband SG, McCarthy MJ, McInnis MG, Maihofer AX, Mertens J, Morken G, Nievergelt CM, Nurnberger J, Pham S, Schoeyen H, Shekhtman T, Shilling PD, Szelinger S, Tarwater B, Yao J, Zandi PP, Kelsoe JR. PMID: 27150464; PMCID: PMC4857276.
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In vivo imaging of dendritic pruning in dentate granule cells. Nat Neurosci. 2016 06; 19(6):788-91.
Gonçalves JT, Bloyd CW, Shtrahman M, Johnston ST, Schafer ST, Parylak SL, Tran T, Chang T, Gage FH. PMID: 27135217; PMCID: PMC4941946.
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PubMed Mentions:
46 Fields:
Translation:
AnimalsCells
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GSK3ß-dependent dysregulation of neurodevelopment in SPG11-patient induced pluripotent stem cell model. Ann Neurol. 2016 May; 79(5):826-840.
Mishra HK, Prots I, Havlicek S, Kohl Z, Perez-Branguli F, Boerstler T, Anneser L, Minakaki G, Wend H, Hampl M, Leone M, Brückner M, Klucken J, Reis A, Boyer L, Schuierer G, Behrens J, Lampert A, Engel FB, Gage FH, Winkler J, Winner B. PMID: 26971897; PMCID: PMC5084783.
View in:
PubMed Mentions:
28 Fields:
-
Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells. Cell Rep. 2016 05 03; 15(5):1024-1036.
Topol A, Zhu S, Hartley BJ, English J, Hauberg ME, Tran N, Rittenhouse CA, Simone A, Ruderfer DM, Johnson J, Readhead B, Hadas Y, Gochman PA, Wang YC, Shah H, Cagney G, Rapoport J, Gage FH, Dudley JT, Sklar P, Mattheisen M, Cotter D, Fang G, Brennand KJ. PMID: 27117414; PMCID: PMC4856588.
View in:
PubMed Mentions:
62 Fields:
Translation:
HumansCells
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Nuclear RNA-seq of single neurons reveals molecular signatures of activation. Nat Commun. 2016 04 19; 7:11022.
Lacar B, Linker SB, Jaeger BN, Krishnaswami SR, Barron JJ, Kelder MJE, Parylak SL, Paquola ACM, Venepally P, Novotny M, O'Connor C, Fitzpatrick C, Erwin JA, Hsu JY, Husband D, McConnell MJ, Lasken R, Gage FH. PMID: 27090946; PMCID: PMC4838832.
View in:
PubMed Mentions:
202 Fields:
Translation:
AnimalsCells
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The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity. J Neurosci. 2016 Apr 13; 36(15):4259-75.
Harrison BJ, Venkat G, Lamb JL, Hutson TH, Drury C, Rau KK, Bunge MB, Mendell LM, Gage FH, Johnson RD, Hill CE, Rouchka EC, Moon LD, Petruska JC. PMID: 27076424; PMCID: PMC4829650.
View in:
PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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α-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy. Acta Neuropathol. 2016 07; 132(1):59-75.
Ettle B, Kerman BE, Valera E, Gillmann C, Schlachetzki JC, Reiprich S, Büttner C, Ekici AB, Reis A, Wegner M, Bäuerle T, Riemenschneider MJ, Masliah E, Gage FH, Winkler J. PMID: 27059609; PMCID: PMC4912450.
View in:
PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
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2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size. Cell Stem Cell. 2016 Apr 07; 18(4):467-80.
Otani T, Marchetto MC, Gage FH, Simons BD, Livesey FJ. PMID: 27049876; PMCID: PMC4826446.
View in:
PubMed Mentions:
140 Fields:
Translation:
HumansAnimalsCells
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Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration. Elife. 2016 03 23; 5.
Zheng X, Boyer L, Jin M, Kim Y, Fan W, Bardy C, Berggren T, Evans RM, Gage FH, Hunter T. PMID: 27008180; PMCID: PMC4846388.
View in:
PubMed Mentions:
65 Fields:
Translation:
HumansCells
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Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons. Nat Protoc. 2016 Mar; 11(3):499-524.
Krishnaswami SR, Grindberg RV, Novotny M, Venepally P, Lacar B, Bhutani K, Linker SB, Pham S, Erwin JA, Miller JA, Hodge R, McCarthy JK, Kelder M, McCorrison J, Aevermann BD, Fuertes FD, Scheuermann RH, Lee J, Lein ES, Schork N, McConnell MJ, Gage FH, Lasken RS. PMID: 26890679; PMCID: PMC4941947.
View in:
PubMed Mentions:
198 Fields:
Translation:
HumansCells
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A Mechanism for Somatic Brain Mosaicism. Cell. 2016 Feb 11; 164(4):593-5.
Weissman IL, Gage FH. PMID: 26871622.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Training the next generation of biomedical investigators in glycosciences. J Clin Invest. 2016 Feb; 126(2):405-8.
Agre P, Bertozzi C, Bissell M, Campbell KP, Cummings RD, Desai UR, Estes M, Flotte T, Fogleman G, Gage F, Ginsburg D, Gordon JI, Hart G, Hascall V, Kiessling L, Kornfeld S, Lowe J, Magnani J, Mahal LK, Medzhitov R, Roberts RJ, Sackstein R, Sarkar R, Schnaar R, Schwartz N, Varki A, Walt D, Weissman I. PMID: 26829621; PMCID: PMC4731185.
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansAnimals
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KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):751-6.
Tang X, Kim J, Zhou L, Wengert E, Zhang L, Wu Z, Carromeu C, Muotri AR, Marchetto MC, Gage FH, Chen G. PMID: 26733678; PMCID: PMC4725523.
View in:
PubMed Mentions:
114 Fields:
Translation:
HumansAnimalsCells
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The different moods of human serotonergic neurons. Mol Psychiatry. 2016 Jan; 21(1):3.
Vadodaria KC, Mertens J, Paquola A, Bardy C, Li X, Jappelli R, Fung L, Marchetto MC, Hamm M, Gorris M, Koch P, Gage FH. PMID: 26678308.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Synaptic activity: An emerging player in schizophrenia. Brain Res. 2017 02 01; 1656:68-75.
Sarkar A, Marchetto MC, Gage FH. PMID: 26723567.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Delayed intramuscular human neurotrophin-3 improves recovery in adult and elderly rats after stroke. Brain. 2016 Jan; 139(Pt 1):259-75.
Duricki DA, Hutson TH, Kathe C, Soleman S, Gonzalez-Carter D, Petruska JC, Shine HD, Chen Q, Wood TC, Bernanos M, Cash D, Williams SC, Gage FH, Moon LD. PMID: 26614754; PMCID: PMC4785394.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Erratum: Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature. 2016 Feb 11; 530(7589):242.
Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames T, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, Calabrese JR, Oedegaard KJ, McCarthy MJ, Zandi PP, Alda M, Nievergelt CM, Pharmacogenomics of Bipolar Disorder Study, Mi S, Brennand KJ, Kelsoe JR, Gage FH, Yao J. PMID: 26605530.
View in:
PubMed Mentions:
3 Fields:
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Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. Stem Cell Reports. 2015 Dec 08; 5(6):933-945.
Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R. PMID: 26610635; PMCID: PMC4881284.
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PubMed Mentions:
34 Fields:
Translation:
HumansCells
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Paradox of pattern separation and adult neurogenesis: A dual role for new neurons balancing memory resolution and robustness. Neurobiol Learn Mem. 2016 Mar; 129:60-8.
Johnston ST, Shtrahman M, Parylak S, Gonçalves JT, Gage FH. PMID: 26549627; PMCID: PMC4792723.
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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REST Regulates Non-Cell-Autonomous Neuronal Differentiation and Maturation of Neural Progenitor Cells via Secretogranin II. J Neurosci. 2015 Nov 04; 35(44):14872-84.
Kim HJ, Denli AM, Wright R, Baul TD, Clemenson GD, Morcos AS, Zhao C, Schafer ST, Gage FH, Kagalwala MN. PMID: 26538656; PMCID: PMC4635134.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature. 2015 Nov 05; 527(7576):95-9.
Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames T, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, Calabrese JR, Ødegaard KJ, McCarthy MJ, Zandi PP, Alda M, Alba M, Nievergelt CM, Pharmacogenomics of Bipolar Disorder Study, Mi S, Brennand KJ, Kelsoe JR, Gage FH, Yao J. PMID: 26524527; PMCID: PMC4742055.
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PubMed Mentions:
266 Fields:
Translation:
HumansCells
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Generation of functional human serotonergic neurons from fibroblasts. Mol Psychiatry. 2016 Jan; 21(1):49-61.
Vadodaria KC, Mertens J, Paquola A, Bardy C, Li X, Jappelli R, Fung L, Marchetto MC, Hamm M, Gorris M, Koch P, Gage FH. PMID: 26503761.
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PubMed Mentions:
75 Fields:
Translation:
HumansAnimalsCells
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Primate-specific ORF0 contributes to retrotransposon-mediated diversity. Cell. 2015 Oct 22; 163(3):583-93.
Denli AM, Narvaiza I, Kerman BE, Pena M, Benner C, Marchetto MC, Diedrich JK, Aslanian A, Ma J, Moresco JJ, Moore L, Hunter T, Saghatelian A, Gage FH. PMID: 26496605.
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PubMed Mentions:
109 Fields:
Translation:
HumansAnimalsCells
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Distinct roles of NMDA receptors at different stages of granule cell development in the adult brain. Elife. 2015 Oct 16; 4:e07871.
Mu Y, Zhao C, Toni N, Yao J, Gage FH. PMID: 26473971; PMCID: PMC4608052.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. Cell Stem Cell. 2015 Dec 03; 17(6):705-718.
Mertens J, Paquola ACM, Ku M, Hatch E, Böhnke L, Ladjevardi S, McGrath S, Campbell B, Lee H, Herdy JR, Gonçalves JT, Toda T, Kim Y, Winkler J, Yao J, Hetzer MW, Gage FH. PMID: 26456686; PMCID: PMC5929130.
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PubMed Mentions:
335 Fields:
Translation:
HumansCells
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Analysis of Spine Motility of Newborn Granule Cells in Acute Brain Slices. Cold Spring Harb Protoc. 2015 Oct 01; 2015(10):934-6.
Tashiro A, Zhao C, Suh H, Gage FH. PMID: 26430257.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Preparation and Use of Retroviral Vectors for Labeling, Imaging, and Genetically Manipulating Cells. Cold Spring Harb Protoc. 2015 Oct 01; 2015(10):883-8.
Tashiro A, Zhao C, Suh H, Gage FH. PMID: 26430260.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Imaging Newborn Granule Cells in Fixed Sections. Cold Spring Harb Protoc. 2015 Oct 01; 2015(10):932-3.
Tashiro A, Zhao C, Suh H, Gage FH. PMID: 26430256.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Purification and Injection of Retroviral Vectors. Cold Spring Harb Protoc. 2015 Oct 01; 2015(10):925-31.
Tashiro A, Zhao C, Suh H, Gage FH. PMID: 26430255.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Enhancer divergence and cis-regulatory evolution in the human and chimp neural crest. Cell. 2015 Sep 24; 163(1):68-83.
Prescott SL, Srinivasan R, Marchetto MC, Grishina I, Narvaiza I, Selleri L, Gage FH, Swigut T, Wysocka J. PMID: 26365491; PMCID: PMC4848043.
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PubMed Mentions:
172 Fields:
Translation:
HumansAnimalsCells
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Neurogenesis in the Adult Hippocampus. Cold Spring Harb Perspect Biol. 2015 Sep 01; 7(9):a018812.
Kempermann G, Song H, Gage FH. PMID: 26330519; PMCID: PMC4563705.
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PubMed Mentions:
404 Fields:
Translation:
HumansCells
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Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS. Nat Neurosci. 2015 Sep; 18(9):1226-9.
Jovicic A, Mertens J, Boeynaems S, Bogaert E, Chai N, Yamada SB, Paul JW, Sun S, Herdy JR, Bieri G, Kramer NJ, Gage FH, Van Den Bosch L, Robberecht W, Gitler AD. PMID: 26308983; PMCID: PMC4552077.
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PubMed Mentions:
337 Fields:
Translation:
HumansAnimalsCells
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Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs. Cell Rep. 2015 Sep 01; 12(9):1385-90.
Firth AL, Menon T, Parker GS, Qualls SJ, Lewis BM, Ke E, Dargitz CT, Wright R, Khanna A, Gage FH, Verma IM. PMID: 26299960; PMCID: PMC4559351.
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PubMed Mentions:
143 Fields:
Translation:
HumansCells
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Spine morphogenesis in newborn granule cells is differentially regulated in the outer and middle molecular layers. J Comp Neurol. 2015 Jul 01; 523(10):1588.
Zhao C, Jou J, Wolff LJ, Sun H, Gage FH. PMID: 26109421.
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PubMed Mentions:
5 Fields:
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MIR137: big impacts from small changes. Nat Neurosci. 2015 Jul; 18(7):931-3.
Han J, Sarkar A, Gage FH. PMID: 26108719.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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In vitro myelin formation using embryonic stem cells. Development. 2015 Jun 15; 142(12):2213-25.
Kerman BE, Kim HJ, Padmanabhan K, Mei A, Georges S, Joens MS, Fitzpatrick JA, Jappelli R, Chandross KJ, August P, Gage FH. PMID: 26015546; PMCID: PMC4483765.
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PubMed Mentions:
40 Fields:
Translation:
AnimalsCells
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Alzheimer's disease: distinct stages in neurogenic decline? Biol Psychiatry. 2015 Apr 15; 77(8):680-2.
Adamowicz DH, Mertens J, Gage FH. PMID: 25835286.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro. Proc Natl Acad Sci U S A. 2015 May 19; 112(20):E2725-34.
Bardy C, van den Hurk M, Eames T, Marchand C, Hernandez RV, Kellogg M, Gorris M, Galet B, Palomares V, Brown J, Bang AG, Mertens J, Böhnke L, Boyer L, Simon S, Gage FH. PMID: 25870293; PMCID: PMC4443325.
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PubMed Mentions:
200 Fields:
Translation:
HumansCells
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Dependence of hippocampal function on ERRγ-regulated mitochondrial metabolism. Cell Metab. 2015 Apr 07; 21(4):628-36.
Pei L, Mu Y, Leblanc M, Alaynick W, Barish GD, Pankratz M, Tseng TW, Kaufman S, Liddle C, Yu RT, Downes M, Pfaff SL, Auwerx J, Gage FH, Evans RM. PMID: 25863252; PMCID: PMC4393848.
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PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
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SOX2 primes the epigenetic landscape in neural precursors enabling proper gene activation during hippocampal neurogenesis. Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15):E1936-45.
Amador-Arjona A, Cimadamore F, Huang CT, Wright R, Lewis S, Gage FH, Terskikh AV. PMID: 25825708; PMCID: PMC4403144.
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PubMed Mentions:
77 Fields:
Translation:
AnimalsCells
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The Wnt adaptor protein ATP6AP2 regulates multiple stages of adult hippocampal neurogenesis. J Neurosci. 2015 Mar 25; 35(12):4983-98.
Schafer ST, Han J, Pena M, von Bohlen Und Halbach O, Peters J, Gage FH. PMID: 25810528; PMCID: PMC4389597.
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PubMed Mentions:
43 Fields:
Translation:
AnimalsCells
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The effect of immature adult-born dentate granule cells on hyponeophagial behavior is related to their roles in learning and memory. Front Syst Neurosci. 2015; 9:34.
Deng W, Gage FH. PMID: 25798094; PMCID: PMC4351587.
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PubMed Mentions:
10
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Improving and accelerating drug development for nervous system disorders. Neuron. 2014 Nov 05; 84(3):546-53.
Pankevich DE, Altevogt BM, Dunlop J, Gage FH, Hyman SE. PMID: 25442933; PMCID: PMC4254615.
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PubMed Mentions:
84 Fields:
Translation:
HumansAnimals
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Enrichment rescues contextual discrimination deficit associated with immediate shock. Hippocampus. 2015 Mar; 25(3):385-92.
Clemenson GD, Lee SW, Deng W, Barrera VR, Iwamoto KS, Fanselow MS, Gage FH. PMID: 25330953; PMCID: PMC4398310.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Regulation and function of adult neurogenesis: from genes to cognition. Physiol Rev. 2014 Oct; 94(4):991-1026.
Aimone JB, Li Y, Lee SW, Clemenson GD, Deng W, Gage FH. PMID: 25287858; PMCID: PMC4280160.
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PubMed Mentions:
276 Fields:
Translation:
HumansAnimalsCells
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Human iPSC neurons display activity-dependent neurotransmitter secretion: aberrant catecholamine levels in schizophrenia neurons. Stem Cell Reports. 2014 Oct 14; 3(4):531-8.
Hook V, Brennand KJ, Kim Y, Toneff T, Funkelstein L, Lee KC, Ziegler M, Gage FH. PMID: 25358781; PMCID: PMC4223699.
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PubMed Mentions:
62 Fields:
Translation:
HumansCells
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Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse. Mol Psychiatry. 2014 Nov; 19(11):1235-42.
Kim SH, Steele JW, Lee SW, Clemenson GD, Carter TA, Treuner K, Gadient R, Wedel P, Glabe C, Barlow C, Ehrlich ME, Gage FH, Gandy S. PMID: 25113378; PMCID: PMC4217144.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimals
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Adult neurogenesis: bridging the gap between mice and humans. Trends Cell Biol. 2014 Oct; 24(10):558-63.
Jessberger S, Gage FH. PMID: 25124338.
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PubMed Mentions:
50 Fields:
Translation:
HumansAnimalsCells
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QnAs with Fred Gage. Proc Natl Acad Sci U S A. 2014 Sep 09; 111(36):12958-9.
Gage F, Nair P. PMID: 25049423; PMCID: PMC4246929.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Mobile DNA elements in the generation of diversity and complexity in the brain. Nat Rev Neurosci. 2014 Aug; 15(8):497-506.
Erwin JA, Marchetto MC, Gage FH. PMID: 25005482; PMCID: PMC4443810.
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PubMed Mentions:
134 Fields:
Translation:
HumansCells
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A quantitative framework to evaluate modeling of cortical development by neural stem cells. Neuron. 2014 Jul 02; 83(1):69-86.
Stein JL, de la Torre-Ubieta L, Tian Y, Parikshak NN, Hernández IA, Marchetto MC, Baker DK, Lu D, Hinman CR, Lowe JK, Wexler EM, Muotri AR, Gage FH, Kosik KS, Geschwind DH. PMID: 24991955; PMCID: PMC4277209.
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PubMed Mentions:
118 Fields:
Translation:
HumansCells
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How to make a hippocampal dentate gyrus granule neuron. Development. 2014 Jun; 141(12):2366-75.
Yu DX, Marchetto MC, Gage FH. PMID: 24917496.
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PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
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Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories. Hippocampus. 2014 Aug; 24(8):905-11.
Bekinschtein P, Kent BA, Oomen CA, Clemenson GD, Gage FH, Saksida LM, Bussey TJ. PMID: 24825389; PMCID: PMC4312906.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Human-induced pluripotent stem cells pave the road for a better understanding of motor neuron disease. Hum Mol Genet. 2014 Sep 15; 23(R1):R27-34.
Winner B, Marchetto MC, Winkler J, Gage FH. PMID: 24821704.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Pre-existing astrocytes form functional perisynaptic processes on neurons generated in the adult hippocampus. Brain Struct Funct. 2015 Jul; 220(4):2027-42.
Krzisch M, Temprana SG, Mongiat LA, Armida J, Schmutz V, Virtanen MA, Kocher-Braissant J, Kraftsik R, Vutskits L, Conzelmann KK, Bergami M, Gage FH, Schinder AF, Toni N. PMID: 24748560; PMCID: PMC4481333.
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PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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Spine morphogenesis in newborn granule cells is differentially regulated in the outer and middle molecular layers. J Comp Neurol. 2014 Aug 15; 522(12):2756-66.
Zhao C, Jou J, Wolff LJ, Sun H, Gage FH. PMID: 24610721; PMCID: PMC4065223.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders. Neuron. 2014 May 07; 82(3):560-72.
Hashimoto-Torii K, Torii M, Fujimoto M, Nakai A, El Fatimy R, Mezger V, Ju MJ, Ishii S, Chao SH, Brennand KJ, Gage FH, Rakic P. PMID: 24726381; PMCID: PMC4051437.
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PubMed Mentions:
63 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia. Mol Psychiatry. 2015 Mar; 20(3):361-8.
Brennand K, Savas JN, Kim Y, Tran N, Simone A, Hashimoto-Torii K, Beaumont KG, Kim HJ, Topol A, Ladran I, Abdelrahim M, Matikainen-Ankney B, Chao SH, Mrksich M, Rakic P, Fang G, Zhang B, Yates JR, Gage FH. PMID: 24686136; PMCID: PMC4182344.
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PubMed Mentions:
228 Fields:
Translation:
HumansAnimalsCells
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Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo. Brain. 2014 May; 137(Pt 5):1496-513.
Rockenstein E, Nuber S, Overk CR, Ubhi K, Mante M, Patrick C, Adame A, Trejo-Morales M, Gerez J, Picotti P, Jensen PH, Campioni S, Riek R, Winkler J, Gage FH, Winner B, Masliah E. PMID: 24662516; PMCID: PMC3999721.
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PubMed Mentions:
112 Fields:
Translation:
HumansAnimalsCells
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Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17):E1723-30.
Firth AL, Dargitz CT, Qualls SJ, Menon T, Wright R, Singer O, Gage FH, Khanna A, Verma IM. PMID: 24706852; PMCID: PMC4035971.
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PubMed Mentions:
109 Fields:
Translation:
HumansCells
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Role of BRCA1 in brain development. Proc Natl Acad Sci U S A. 2014 Apr 01; 111(13):E1240-8.
Pao GM, Zhu Q, Perez-Garcia CG, Chou SJ, Suh H, Gage FH, O'Leary DD, Verma IM. PMID: 24639535; PMCID: PMC3977248.
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PubMed Mentions:
52 Fields:
Translation:
AnimalsCells
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Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors. Nat Neurosci. 2014 Apr; 17(4):513-21.
Crotti A, Benner C, Kerman BE, Gosselin D, Lagier-Tourenne C, Zuccato C, Cattaneo E, Gage FH, Cleveland DW, Glass CK. PMID: 24584051; PMCID: PMC4113004.
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PubMed Mentions:
160 Fields:
Translation:
HumansAnimalsCells
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Enhancing induced pluripotent stem cell models of schizophrenia. JAMA Psychiatry. 2014 Mar; 71(3):334-5.
Wright R, Réthelyi JM, Gage FH. PMID: 24382673.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Modeling hippocampal neurogenesis using human pluripotent stem cells. Stem Cell Reports. 2014 Mar 11; 2(3):295-310.
Yu DX, Di Giorgio FP, Yao J, Marchetto MC, Brennand K, Wright R, Mei A, McHenry L, Lisuk D, Grasmick JM, Silberman P, Silberman G, Jappelli R, Gage FH. PMID: 24672753; PMCID: PMC3964286.
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PubMed Mentions:
135 Fields:
Translation:
HumansCells
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SnapShot: adult hippocampal neurogenesis. Cell. 2014 Feb 27; 156(5):1114-1114.e1.
Vadodaria KC, Gage FH. PMID: 24581504.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Increasing the resolution of the adult neurogenesis picture. F1000Prime Rep. 2014; 6:8.
Lacar B, Parylak SL, Vadodaria KC, Sarkar A, Gage FH. PMID: 24592320; PMCID: PMC3914506.
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PubMed Mentions:
9
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Mother's milk programs offspring's cognition. Nat Neurosci. 2014 Jan; 17(1):8-9.
Parylak SL, Deng W, Gage FH. PMID: 24369371.
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PubMed Mentions:
3 Fields:
Translation:
Animals
-
Your brain under the microscope: the promise of stem cells. Cerebrum. 2014 Jan; 2014:1.
Marchetto MC, Gage FH. PMID: 25009691; PMCID: PMC4087191.
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PubMed Mentions:
5
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Temporally selective contextual encoding in the dentate gyrus of the hippocampus. Nat Commun. 2014; 5:3181.
Rangel LM, Alexander AS, Aimone JB, Wiles J, Gage FH, Chiba AA, Quinn LK. PMID: 24518986; PMCID: PMC3929785.
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PubMed Mentions:
48 Fields:
Translation:
Animals
-
Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons. Hum Mol Genet. 2014 May 15; 23(10):2527-41.
Havlicek S, Kohl Z, Mishra HK, Prots I, Eberhardt E, Denguir N, Wend H, Plötz S, Boyer L, Marchetto MC, Aigner S, Sticht H, Groemer TW, Hehr U, Lampert A, Schlötzer-Schrehardt U, Winkler J, Gage FH, Winner B. PMID: 24381312; PMCID: PMC3990156.
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PubMed Mentions:
67 Fields:
Translation:
HumansCells
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The role of transposable elements in health and diseases of the central nervous system. J Neurosci. 2013 Nov 06; 33(45):17577-86.
Reilly MT, Faulkner GJ, Dubnau J, Ponomarev I, Gage FH. PMID: 24198348; PMCID: PMC3818539.
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PubMed Mentions:
78 Fields:
Translation:
HumansCells
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Mosaic copy number variation in human neurons. Science. 2013 Nov 01; 342(6158):632-7.
McConnell MJ, Lindberg MR, Brennand KJ, Piper JC, Voet T, Cowing-Zitron C, Shumilina S, Lasken RS, Vermeesch JR, Hall IM, Gage FH. PMID: 24179226; PMCID: PMC3975283.
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PubMed Mentions:
281 Fields:
Translation:
HumansCells
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Neural stem cells: generating and regenerating the brain. Neuron. 2013 Oct 30; 80(3):588-601.
Gage FH, Temple S. PMID: 24183012.
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PubMed Mentions:
238 Fields:
Translation:
HumansAnimalsCells
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BDNF in the dentate gyrus is required for consolidation of "pattern-separated" memories. Cell Rep. 2013 Nov 14; 5(3):759-68.
Bekinschtein P, Kent BA, Oomen CA, Clemenson GD, Gage FH, Saksida LM, Bussey TJ. PMID: 24209752; PMCID: PMC3898274.
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PubMed Mentions:
55 Fields:
Translation:
HumansAnimals
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Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov; 140(22):4633-44.
Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S, Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ, Jones AR, Amaral DG, Šestan N, Gage FH, Lein ES. PMID: 24154525; PMCID: PMC3817946.
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PubMed Mentions:
40 Fields:
Translation:
AnimalsCells
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Differential L1 regulation in pluripotent stem cells of humans and apes. Nature. 2013 Nov 28; 503(7477):525-529.
Marchetto MCN, Narvaiza I, Denli AM, Benner C, Lazzarini TA, Nathanson JL, Paquola ACM, Desai KN, Herai RH, Weitzman MD, Yeo GW, Muotri AR, Gage FH. PMID: 24153179; PMCID: PMC4064720.
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PubMed Mentions:
125 Fields:
Translation:
HumansAnimalsCells
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A regenerative approach to the treatment of multiple sclerosis. Nature. 2013 Oct 17; 502(7471):327-332.
Deshmukh VA, Tardif V, Lyssiotis CA, Green CC, Kerman B, Kim HJ, Padmanabhan K, Swoboda JG, Ahmad I, Kondo T, Gage FH, Theofilopoulos AN, Lawson BR, Schultz PG, Lairson LL. PMID: 24107995; PMCID: PMC4431622.
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PubMed Mentions:
240 Fields:
Translation:
AnimalsCells
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Novel tools, classic techniques: evolutionary studies using primate pluripotent stem cells. Biol Psychiatry. 2014 Jun 15; 75(12):929-35.
Hrvoj-Mihic B, Marchetto MC, Gage FH, Semendeferi K, Muotri AR. PMID: 24041506.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury. PLoS One. 2013; 8(7):e69286.
Sung TC, Chen Z, Thuret S, Vilar M, Gage FH, Riek R, Lee KF. PMID: 23935974; PMCID: PMC3720591.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Therapeutic translation of iPSCs for treating neurological disease. Cell Stem Cell. 2013 Jun 06; 12(6):678-88.
Yu DX, Marchetto MC, Gage FH. PMID: 23746977.
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PubMed Mentions:
46 Fields:
Translation:
HumansCells
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Response to comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells". Sci Transl Med. 2013 Jun 05; 5(188):188lr2.
Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa M, Kawata A, Yoshida M, Nakahata T, Takahashi R, Marchetto MC, Gage FH, Yamanaka S, Inoue H. PMID: 23740898.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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FOXO4 is necessary for neural differentiation of human embryonic stem cells. Aging Cell. 2013 Jun; 12(3):518-22.
Vilchez D, Boyer L, Lutz M, Merkwirth C, Morantte I, Tse C, Spencer B, Page L, Masliah E, Berggren WT, Gage FH, Dillin A. PMID: 23551888; PMCID: PMC4864013.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells. Stem Cell Res. 2013 Sep; 11(2):743-57.
Tang X, Zhou L, Wagner AM, Marchetto MC, Muotri AR, Gage FH, Chen G. PMID: 23759711; PMCID: PMC3979966.
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PubMed Mentions:
82 Fields:
Translation:
HumansAnimalsCells
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A hypothesis for temporal coding of young and mature granule cells. Front Neurosci. 2013; 7:75.
Rangel LM, Quinn LK, Chiba AA, Gage FH, Aimone JB. PMID: 23717259; PMCID: PMC3653099.
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PubMed Mentions:
17
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Molecular layer perforant path-associated cells contribute to feed-forward inhibition in the adult dentate gyrus. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9106-11.
Li Y, Stam FJ, Aimone JB, Goulding M, Callaway EM, Gage FH. PMID: 23671081; PMCID: PMC3670356.
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PubMed Mentions:
40 Fields:
Translation:
AnimalsCells
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Enhanced neurotrophic distribution, cell signaling and neuroprotection following substantia nigral versus striatal delivery of AAV2-NRTN (CERE-120). Neurobiol Dis. 2013 Oct; 58:38-48.
Herzog CD, Brown L, Kruegel BR, Wilson A, Tansey MG, Gage FH, Johnson EM, Bartus RT. PMID: 23631873.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nat Med. 2013 Apr; 19(4):473-80.
Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, Zhang D, Gage FH, Ranscht B, Zhang YW, Lipton SA, Hong W, Xu H. PMID: 23524343; PMCID: PMC3911880.
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PubMed Mentions:
141 Fields:
Translation:
HumansAnimalsCells
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Selection of distinct populations of dentate granule cells in response to inputs as a mechanism for pattern separation in mice. Elife. 2013 Mar 20; 2:e00312.
Deng W, Mayford M, Gage FH. PMID: 23538967; PMCID: PMC3602954.
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PubMed Mentions:
87 Fields:
Translation:
AnimalsCells
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Dynamic association of NUP98 with the human genome. PLoS Genet. 2013; 9(2):e1003308.
Liang Y, Franks TM, Marchetto MC, Gage FH, Hetzer MW. PMID: 23468646; PMCID: PMC3585015.
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PubMed Mentions:
92 Fields:
Translation:
HumansCells
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Paired related homeobox protein 1 is a regulator of stemness in adult neural stem/progenitor cells. J Neurosci. 2013 Feb 27; 33(9):4066-75.
Shimozaki K, Clemenson GD, Gage FH. PMID: 23447615; PMCID: PMC6619329.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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Conversion of human fibroblasts to angioblast-like progenitor cells. Nat Methods. 2013 Jan; 10(1):77-83.
Kurian L, Sancho-Martinez I, Nivet E, Aguirre A, Moon K, Pendaries C, Volle-Challier C, Bono F, Herbert JM, Pulecio J, Xia Y, Li M, Montserrat N, Ruiz S, Dubova I, Rodriguez C, Denli AM, Boscolo FS, Thiagarajan RD, Gage FH, Loring JF, Laurent LC, Izpisua Belmonte JC. PMID: 23202434; PMCID: PMC3531579.
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PubMed Mentions:
85 Fields:
Translation:
HumansAnimalsCells
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Role of α-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus. J Neurosci. 2012 Nov 21; 32(47):16906-16.
Winner B, Regensburger M, Schreglmann S, Boyer L, Prots I, Rockenstein E, Mante M, Zhao C, Winkler J, Masliah E, Gage FH. PMID: 23175842; PMCID: PMC4962062.
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PubMed Mentions:
71 Fields:
Translation:
HumansAnimalsCells
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Induced pluripotent stem cells: the new patient? Nat Rev Mol Cell Biol. 2012 Nov; 13(11):713-26.
Bellin M, Marchetto MC, Gage FH, Mummery CL. PMID: 23034453.
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PubMed Mentions:
219 Fields:
Translation:
HumansAnimalsCells
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An exploratory study of combination buspirone and melatonin SR in major depressive disorder (MDD): a possible role for neurogenesis in drug discovery. J Psychiatr Res. 2012 Dec; 46(12):1553-63.
Fava M, Targum SD, Nierenberg AA, Bleicher LS, Carter TA, Wedel PC, Hen R, Gage FH, Barlow C. PMID: 22998742.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimals
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Increased proteasome activity in human embryonic stem cells is regulated by PSMD11. Nature. 2012 Sep 13; 489(7415):304-8.
Vilchez D, Boyer L, Morantte I, Lutz M, Merkwirth C, Joyce D, Spencer B, Page L, Masliah E, Berggren WT, Gage FH, Dillin A. PMID: 22972301; PMCID: PMC5215918.
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PubMed Mentions:
199 Fields:
Translation:
HumansCells
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Drug screening for ALS using patient-specific induced pluripotent stem cells. Sci Transl Med. 2012 Aug 01; 4(145):145ra104.
Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa M, Kawata A, Yoshida M, Nakahata T, Takahashi R, Marchetto MC, Gage FH, Yamanaka S, Inoue H. PMID: 22855461.
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PubMed Mentions:
254 Fields:
Translation:
HumansCells
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Dopaminergic differentiation of human pluripotent cells. Curr Protoc Stem Cell Biol. 2012 Aug; Chapter 1:Unit1H.6.
Boyer LF, Campbell B, Larkin S, Mu Y, Gage FH. PMID: 22872424.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12556-61.
Giorgetti A, Marchetto MC, Li M, Yu D, Fazzina R, Mu Y, Adamo A, Paramonov I, Cardoso JC, Monasterio MB, Bardy C, Cassiani-Ingoni R, Liu GH, Gage FH, Izpisua Belmonte JC. PMID: 22814375; PMCID: PMC3412010.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
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Modeling brain disease in a dish: really? Cell Stem Cell. 2012 Jun 14; 10(6):642-645.
Marchetto MC, Gage FH. PMID: 22704498.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Electroconvulsive seizure promotes spine maturation in newborn dentate granule cells in adult rat. Dev Neurobiol. 2012 Jun; 72(6):937-42.
Zhao C, Warner-Schmidt J, Duman RS, Gage FH. PMID: 21976455; PMCID: PMC3623264.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Neural stem cells: mechanisms and modeling. Protein Cell. 2012 Apr; 3(4):251-61.
Yao J, Mu Y, Gage FH. PMID: 22549585; PMCID: PMC4875476.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Modeling psychiatric disorders at the cellular and network levels. Mol Psychiatry. 2012 Dec; 17(12):1239-53.
Brennand KJ, Simone A, Tran N, Gage FH. PMID: 22472874; PMCID: PMC3465628.
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PubMed Mentions:
60 Fields:
Translation:
HumansAnimalsCells
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Local generation of glia is a major astrocyte source in postnatal cortex. Nature. 2012 Mar 28; 484(7394):376-80.
Ge WP, Miyawaki A, Gage FH, Jan YN, Jan LY. PMID: 22456708; PMCID: PMC3777276.
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PubMed Mentions:
238 Fields:
Translation:
AnimalsCells
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Gene expression profiling of neural stem cells and their neuronal progeny reveals IGF2 as a regulator of adult hippocampal neurogenesis. J Neurosci. 2012 Mar 07; 32(10):3376-87.
Bracko O, Singer T, Aigner S, Knobloch M, Winner B, Ray J, Clemenson GD, Suh H, Couillard-Despres S, Aigner L, Gage FH, Jessberger S. PMID: 22399759; PMCID: PMC3338187.
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PubMed Mentions:
103 Fields:
Translation:
AnimalsCells
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What makes each brain unique. Sci Am. 2012 Mar; 306(3):26-31.
Gage FH, Muotri AR. PMID: 22375319.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Development of GABAergic inputs controls the contribution of maturing neurons to the adult hippocampal network. Proc Natl Acad Sci U S A. 2012 Mar 13; 109(11):4290-5.
Li Y, Aimone JB, Xu X, Callaway EM, Gage FH. PMID: 22371596; PMCID: PMC3306704.
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PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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Enhanced functional recovery in MRL/MpJ mice after spinal cord dorsal hemisection. PLoS One. 2012; 7(2):e30904.
Thuret S, Thallmair M, Horky LL, Gage FH. PMID: 22348029; PMCID: PMC3278405.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature. 2012 Jan 25; 482(7384):216-20.
Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LS. PMID: 22278060; PMCID: PMC3338985.
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PubMed Mentions:
611 Fields:
Translation:
HumansCells
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ISSCR: beginning the next chapter. Cell Stem Cell. 2012 Jan 06; 10(1):29-31.
Gage FH. PMID: 22226353.
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Translation:
HumansAnimalsCells
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The enemy within: intronic miR-26b represses its host gene, ctdsp2, to regulate neurogenesis. Genes Dev. 2012 Jan 01; 26(1):6-10.
Han J, Denli AM, Gage FH. PMID: 22215805; PMCID: PMC3258967.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Transplantation in the future. Prog Brain Res. 2012; 201:7-13.
Gage FH. PMID: 23186707.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Transplantation in the future. Prog Brain Res. 2012; 200:7-13.
Gage FH. PMID: 23195412.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
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Monosynaptic inputs to new neurons in the dentate gyrus. Nat Commun. 2012; 3:1107.
Vivar C, Potter MC, Choi J, Lee JY, Stringer TP, Callaway EM, Gage FH, Suh H, van Praag H. PMID: 23033083; PMCID: PMC4603575.
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PubMed Mentions:
164 Fields:
Translation:
AnimalsCells
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Differential effects of brain-derived neurotrophic factor and neurotrophin-3 on hindlimb function in paraplegic rats. Eur J Neurosci. 2012 Jan; 35(2):221-32.
Boyce VS, Park J, Gage FH, Mendell LM. PMID: 22211901; PMCID: PMC3509221.
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PubMed Mentions:
65 Translation:
HumansAnimalsCells
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Adult hippocampal neurogenesis and its role in Alzheimer's disease. Mol Neurodegener. 2011 Dec 22; 6:85.
Mu Y, Gage FH. PMID: 22192775; PMCID: PMC3261815.
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PubMed Mentions:
433 Fields:
Translation:
HumansAnimalsCells
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SRY-box-containing gene 2 regulation of nuclear receptor tailless (Tlx) transcription in adult neural stem cells. J Biol Chem. 2012 Feb 17; 287(8):5969-78.
Shimozaki K, Zhang CL, Suh H, Denli AM, Evans RM, Gage FH. PMID: 22194602; PMCID: PMC3285364.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20382-7.
Coufal NG, Garcia-Perez JL, Peng GE, Marchetto MC, Muotri AR, Mu Y, Carson CT, Macia A, Moran JV, Gage FH. PMID: 22159035; PMCID: PMC3251057.
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PubMed Mentions:
125 Fields:
Translation:
HumansAnimalsCells
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Concise review: the promise of human induced pluripotent stem cell-based studies of schizophrenia. Stem Cells. 2011 Dec; 29(12):1915-22.
Brennand KJ, Gage FH. PMID: 22009633; PMCID: PMC3381343.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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New neurons in an aged brain. Behav Brain Res. 2012 Feb 14; 227(2):497-507.
Lee SW, Clemenson GD, Gage FH. PMID: 22024433; PMCID: PMC3264739.
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PubMed Mentions:
65 Fields:
Translation:
AnimalsCells
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Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb. EMBO Mol Med. 2011 Dec; 3(12):742-54.
Kuwabara T, Kagalwala MN, Onuma Y, Ito Y, Warashina M, Terashima K, Sanosaka T, Nakashima K, Gage FH, Asashima M. PMID: 21984534; PMCID: PMC3377118.
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PubMed Mentions:
60 Fields:
Translation:
AnimalsCells
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Modeling psychiatric disorders through reprogramming. Dis Model Mech. 2012 Jan; 5(1):26-32.
Brennand KJ, Gage FH. PMID: 21954066; PMCID: PMC3255540.
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PubMed Mentions:
30 Fields:
Translation:
HumansCells
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BRCA1 tumour suppression occurs via heterochromatin-mediated silencing. Nature. 2011 Sep 07; 477(7363):179-84.
Zhu Q, Pao GM, Huynh AM, Suh H, Tonnu N, Nederlof PM, Gage FH, Verma IM. PMID: 21901007; PMCID: PMC3240576.
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PubMed Mentions:
267 Fields:
Translation:
HumansAnimalsCells
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Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises. Hum Mol Genet. 2011 Oct 15; 20(R2):R109-15.
Marchetto MC, Brennand KJ, Boyer LF, Gage FH. PMID: 21828073; PMCID: PMC4447776.
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PubMed Mentions:
99 Fields:
Translation:
HumansAnimalsCells
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Genetically encoding unnatural amino acids in neural stem cells and optically reporting voltage-sensitive domain changes in differentiated neurons. Stem Cells. 2011 Aug; 29(8):1231-40.
Shen B, Xiang Z, Miller B, Louie G, Wang W, Noel JP, Gage FH, Wang L. PMID: 21681861; PMCID: PMC3209808.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes. Mol Ther. 2011 Oct; 19(10):1905-12.
Hester ME, Murtha MJ, Song S, Rao M, Miranda CJ, Meyer K, Tian J, Boulting G, Schaffer DV, Zhu MX, Pfaff SL, Gage FH, Kaspar BK. PMID: 21772256; PMCID: PMC3188742.
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PubMed Mentions:
103 Fields:
Translation:
HumansCells
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Brief report: efficient generation of hematopoietic precursors and progenitors from human pluripotent stem cell lines. Stem Cells. 2011 Jul; 29(7):1158-64.
Woods NB, Parker AS, Moraghebi R, Lutz MK, Firth AL, Brennand KJ, Berggren WT, Raya A, Izpisúa Belmonte JC, Gage FH, Verma IM. PMID: 21544903; PMCID: PMC3254148.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
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Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation. Neuron. 2011 May 26; 70(4):589-96.
Aimone JB, Deng W, Gage FH. PMID: 21609818; PMCID: PMC3240575.
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PubMed Mentions:
301 Fields:
Translation:
HumansAnimals
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Modelling schizophrenia using human induced pluripotent stem cells. Nature. 2011 May 12; 473(7346):221-5.
Brennand KJ, Simone A, Jou J, Gelboin-Burkhart C, Tran N, Sangar S, Li Y, Mu Y, Chen G, Yu D, McCarthy S, Sebat J, Gage FH. PMID: 21490598; PMCID: PMC3392969.
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PubMed Mentions:
662 Fields:
Translation:
HumansCells
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Dopaminergic modulation of cortical inputs during maturation of adult-born dentate granule cells. J Neurosci. 2011 Mar 16; 31(11):4113-23.
Mu Y, Zhao C, Gage FH. PMID: 21411652; PMCID: PMC3073019.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells. PLoS One. 2011 Mar 02; 6(3):e17540.
Yuan SH, Martin J, Elia J, Flippin J, Paramban RI, Hefferan MP, Vidal JG, Mu Y, Killian RL, Israel MA, Emre N, Marsala S, Marsala M, Gage FH, Goldstein LS, Carson CT. PMID: 21407814; PMCID: PMC3047583.
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PubMed Mentions:
199 Fields:
Translation:
HumansAnimalsCells
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Neurodegenerative disease and adult neurogenesis. Eur J Neurosci. 2011 Mar; 33(6):1139-51.
Winner B, Kohl Z, Gage FH. PMID: 21395858.
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PubMed Mentions:
186 Translation:
HumansAnimalsCells
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Modeling new neuron function: a history of using computational neuroscience to study adult neurogenesis. Eur J Neurosci. 2011 Mar; 33(6):1160-9.
Aimone JB, Gage FH. PMID: 21395860.
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PubMed Mentions:
28 Translation:
AnimalsCells
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In vivo demonstration that alpha-synuclein oligomers are toxic. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4194-9.
Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, Pham E, Masliah E, Gage FH, Riek R. PMID: 21325059; PMCID: PMC3053976.
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PubMed Mentions:
662 Fields:
Translation:
AnimalsCells
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Investigating synapse formation and function using human pluripotent stem cell-derived neurons. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):3005-10.
Kim JE, O'Sullivan ML, Sanchez CA, Hwang M, Israel MA, Brennand K, Deerinck TJ, Goldstein LS, Gage FH, Ellisman MH, Ghosh A. PMID: 21278334; PMCID: PMC3041068.
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PubMed Mentions:
80 Fields:
Translation:
HumansAnimalsCells
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Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice. Neurobiol Dis. 2011 Mar; 41(3):706-16.
Winner B, Melrose HL, Zhao C, Hinkle KM, Yue M, Kent C, Braithwaite AT, Ogholikhan S, Aigner R, Winkler J, Farrer MJ, Gage FH. PMID: 21168496; PMCID: PMC3059106.
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PubMed Mentions:
101 Fields:
Translation:
HumansAnimalsCells
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High-efficient generation of induced pluripotent stem cells from human astrocytes. PLoS One. 2010 Dec 09; 5(12):e15526.
Ruiz S, Brennand K, Panopoulos AD, Herrerías A, Gage FH, Izpisua-Belmonte JC. PMID: 21170306; PMCID: PMC3000364.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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L1 retrotransposition in neurons is modulated by MeCP2. Nature. 2010 Nov 18; 468(7322):443-6.
Muotri AR, Marchetto MC, Coufal NG, Oefner R, Yeo G, Nakashima K, Gage FH. PMID: 21085180; PMCID: PMC3059197.
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PubMed Mentions:
323 Fields:
Translation:
HumansAnimalsCells
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PI3K mediated electrotaxis of embryonic and adult neural progenitor cells in the presence of growth factors. Exp Neurol. 2011 Jan; 227(1):210-7.
Meng X, Arocena M, Penninger J, Gage FH, Zhao M, Song B. PMID: 21092738; PMCID: PMC3821524.
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PubMed Mentions:
63 Fields:
Translation:
AnimalsCells
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A distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis. J Comp Neurol. 2010 Nov 15; 518(22):4479-90.
Mathews EA, Morgenstern NA, Piatti VC, Zhao C, Jessberger S, Schinder AF, Gage FH. PMID: 20886617; PMCID: PMC2997649.
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PubMed Mentions:
65 Fields:
Translation:
AnimalsCells
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A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell. 2010 Nov 12; 143(4):527-39.
Marchetto MC, Carromeu C, Acab A, Yu D, Yeo GW, Mu Y, Chen G, Gage FH, Muotri AR. PMID: 21074045; PMCID: PMC3003590.
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PubMed Mentions:
674 Fields:
Translation:
HumansCells
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Epigenetic choreographers of neurogenesis in the adult mammalian brain. Nat Neurosci. 2010 Nov; 13(11):1338-44.
Ma DK, Marchetto MC, Guo JU, Ming GL, Gage FH, Song H. PMID: 20975758; PMCID: PMC3324277.
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PubMed Mentions:
151 Fields:
Translation:
HumansAnimalsCells
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Put them out to pasture? What are old granule cells good for, anyway...? Hippocampus. 2010 Oct; 20(10):1124-5.
Aimone JB, Deng W, Gage FH. PMID: 20848611.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Intramuscular AAV delivery of NT-3 alters synaptic transmission to motoneurons in adult rats. Eur J Neurosci. 2010 Sep; 32(6):997-1005.
Petruska JC, Kitay B, Boyce VS, Kaspar BK, Pearse DD, Gage FH, Mendell LM. PMID: 20849530; PMCID: PMC2943849.
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PubMed Mentions:
26 Translation:
HumansAnimalsCells
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Puma is required for p53-induced depletion of adult stem cells. Nat Cell Biol. 2010 Oct; 12(10):993-8.
Liu D, Ou L, Clemenson GD, Chao C, Lutske ME, Zambetti GP, Gage FH, Xu Y. PMID: 20818388; PMCID: PMC3025300.
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PubMed Mentions:
63 Fields:
Translation:
AnimalsCells
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Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise. Proc Natl Acad Sci U S A. 2010 Aug 17; 107(33):14863-8.
Valdez G, Tapia JC, Kang H, Clemenson GD, Gage FH, Lichtman JW, Sanes JR. PMID: 20679195; PMCID: PMC2930485.
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PubMed Mentions:
283 Fields:
Translation:
AnimalsCells
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Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus. Cell Stem Cell. 2010 Jul 02; 7(1):78-89.
Mira H, Andreu Z, Suh H, Lie DC, Jessberger S, Consiglio A, San Emeterio J, Hortigüela R, Marqués-Torrejón MA, Nakashima K, Colak D, Götz M, Fariñas I, Gage FH. PMID: 20621052.
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PubMed Mentions:
238 Fields:
Translation:
HumansAnimalsCells
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Signaling in adult neurogenesis. Curr Opin Neurobiol. 2010 Aug; 20(4):416-23.
Mu Y, Lee SW, Gage FH. PMID: 20471243; PMCID: PMC2942965.
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PubMed Mentions:
97 Fields:
Translation:
AnimalsCells
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Adult neurogenesis: integrating theories and separating functions. Trends Cogn Sci. 2010 Jul; 14(7):325-37.
Aimone JB, Deng W, Gage FH. PMID: 20471301; PMCID: PMC2904863.
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PubMed Mentions:
124 Fields:
Translation:
HumansAnimalsCells
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LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes? Trends Neurosci. 2010 Aug; 33(8):345-54.
Singer T, McConnell MJ, Marchetto MC, Coufal NG, Gage FH. PMID: 20471112; PMCID: PMC2916067.
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PubMed Mentions:
127 Fields:
Translation:
HumansCells
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Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases. Hum Mol Genet. 2010 Apr 15; 19(R1):R71-6.
Marchetto MC, Winner B, Gage FH. PMID: 20418487; PMCID: PMC2875052.
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PubMed Mentions:
70 Fields:
Translation:
HumansCells
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Spatial learning sculpts the dendritic arbor of adult-born hippocampal neurons. Proc Natl Acad Sci U S A. 2010 Apr 27; 107(17):7963-8.
Tronel S, Fabre A, Charrier V, Oliet SH, Gage FH, Abrous DN. PMID: 20375283; PMCID: PMC2867872.
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PubMed Mentions:
98 Fields:
Translation:
AnimalsCells
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New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci. 2010 May; 11(5):339-50.
Deng W, Aimone JB, Gage FH. PMID: 20354534; PMCID: PMC2886712.
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PubMed Mentions:
933 Fields:
Translation:
HumansAnimalsCells
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Mechanisms underlying inflammation in neurodegeneration. Cell. 2010 Mar 19; 140(6):918-34.
Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH. PMID: 20303880; PMCID: PMC2873093.
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PubMed Mentions:
1520 Fields:
Translation:
HumansAnimals
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Molecular and cellular mechanisms contributing to the regulation, proliferation and differentiation of neural stem cells in the adult dentate gyrus. Keio J Med. 2010; 59(3):79-83.
Gage FH. PMID: 20881448.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal. Nat Cell Biol. 2010 Jan; 12(1):31-40; sup pp 1-9.
Qu Q, Sun G, Li W, Yang S, Ye P, Zhao C, Yu RT, Gage FH, Evans RM, Shi Y. PMID: 20010817; PMCID: PMC2880892.
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PubMed Mentions:
152 Fields:
Translation:
AnimalsCells
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Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource. Front Neurosci. 2009; 3:55.
Overall RW, Kempermann G, Peirce J, Lu L, Goldowitz D, Gage FH, Goodwin S, Smit AB, Airey DC, Rosen GD, Schalkwyk LC, Sutter TR, Nowakowski RS, Whatley S, Williams RW. PMID: 20582282; PMCID: PMC2858614.
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53
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[Epigenetic mechanisms regulating neural cell fate determination]. No To Hattatsu. 2009 Nov; 41(6):411-4.
Nakashima K, Kohyama J, Namihira M, Gage FH, Okano H, Sawamoto K. PMID: 19928537.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain. J Neurosci. 2009 Oct 28; 29(43):13532-42.
Deng W, Saxe MD, Gallina IS, Gage FH. PMID: 19864566; PMCID: PMC2787190.
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PubMed Mentions:
245 Fields:
Translation:
AnimalsCells
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Environmental influence on L1 retrotransposons in the adult hippocampus. Hippocampus. 2009 Oct; 19(10):1002-7.
Muotri AR, Zhao C, Marchetto MC, Gage FH. PMID: 19771587; PMCID: PMC2758700.
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PubMed Mentions:
74 Fields:
Translation:
AnimalsCells
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Making a neuron: Cdk5 in embryonic and adult neurogenesis. Trends Neurosci. 2009 Nov; 32(11):575-82.
Jessberger S, Gage FH, Eisch AJ, Lagace DC. PMID: 19782409; PMCID: PMC2767479.
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PubMed Mentions:
50 Fields:
Translation:
HumansAnimalsCells
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Transcriptional signature and memory retention of human-induced pluripotent stem cells. PLoS One. 2009 Sep 18; 4(9):e7076.
Marchetto MC, Yeo GW, Kainohana O, Marsala M, Gage FH, Muotri AR. PMID: 19763270; PMCID: PMC2741600.
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PubMed Mentions:
154 Fields:
Translation:
HumansAnimalsCells
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Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis. Cell Stem Cell. 2009 Sep 04; 5(3):310-9.
Tamaki SJ, Jacobs Y, Dohse M, Capela A, Cooper JD, Reitsma M, He D, Tushinski R, Belichenko PV, Salehi A, Mobley W, Gage FH, Huhn S, Tsukamoto AS, Weissman IL, Uchida N. PMID: 19733542.
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PubMed Mentions:
59 Fields:
Translation:
HumansAnimalsCells
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Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis. Nat Neurosci. 2009 Sep; 12(9):1097-105.
Kuwabara T, Hsieh J, Muotri A, Yeo G, Warashina M, Lie DC, Moore L, Nakashima K, Asashima M, Gage FH. PMID: 19701198; PMCID: PMC2764260.
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PubMed Mentions:
304 Fields:
Translation:
AnimalsCells
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L1 retrotransposition in human neural progenitor cells. Nature. 2009 Aug 27; 460(7259):1127-31.
Coufal NG, Garcia-Perez JL, Peng GE, Yeo GW, Mu Y, Lovci MT, Morell M, O'Shea KS, Moran JV, Gage FH. PMID: 19657334; PMCID: PMC2909034.
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PubMed Mentions:
441 Fields:
Translation:
HumansCells
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A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science. 2009 Jul 10; 325(5937):210-3.
Clelland CD, Choi M, Romberg C, Clemenson GD, Fragniere A, Tyers P, Jessberger S, Saksida LM, Barker RA, Gage FH, Bussey TJ. PMID: 19590004; PMCID: PMC2997634.
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PubMed Mentions:
752 Fields:
Translation:
AnimalsCells
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Hippocampus-dependent learning is associated with adult neurogenesis in MRL/MpJ mice. Hippocampus. 2009 Jul; 19(7):658-69.
Thuret S, Toni N, Aigner S, Yeo GW, Gage FH. PMID: 19140178.
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PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
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Muscle injection of AAV-NT3 promotes anatomical reorganization of CST axons and improves behavioral outcome following SCI. J Neurotrauma. 2009 Jul; 26(7):941-53.
Fortun J, Puzis R, Pearse DD, Gage FH, Bunge MB. PMID: 19275471.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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GABA-cAMP response element-binding protein signaling regulates maturation and survival of newly generated neurons in the adult hippocampus. J Neurosci. 2009 Jun 24; 29(25):7966-77.
Jagasia R, Steib K, Englberger E, Herold S, Faus-Kessler T, Saxe M, Gage FH, Song H, Lie DC. PMID: 19553437; PMCID: PMC2776747.
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PubMed Mentions:
178 Fields:
Translation:
AnimalsCells
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Alpha9 integrin promotes neurite outgrowth on tenascin-C and enhances sensory axon regeneration. J Neurosci. 2009 Apr 29; 29(17):5546-57.
Andrews MR, Czvitkovich S, Dassie E, Vogelaar CF, Faissner A, Blits B, Gage FH, ffrench-Constant C, Fawcett JW. PMID: 19403822; PMCID: PMC6665849.
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PubMed Mentions:
80 Fields:
Translation:
HumansAnimalsCells
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A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell. 2009 Apr 03; 137(1):47-59.
Saijo K, Winner B, Carson CT, Collier JG, Boyer L, Rosenfeld MG, Gage FH, Glass CK. PMID: 19345186; PMCID: PMC2754279.
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PubMed Mentions:
460 Fields:
Translation:
AnimalsCells
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miR-9 and TLX: chasing tails in neural stem cells. Nat Struct Mol Biol. 2009 Apr; 16(4):346-7.
Denli AM, Cao X, Gage FH. PMID: 19343066.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Notch keeps ependymal cells in line. Nat Neurosci. 2009 Mar; 12(3):243-5.
Zhao C, Suh H, Gage FH. PMID: 19238183.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Computational influence of adult neurogenesis on memory encoding. Neuron. 2009 Jan 29; 61(2):187-202.
Aimone JB, Wiles J, Gage FH. PMID: 19186162; PMCID: PMC2670434.
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PubMed Mentions:
158 Fields:
Translation:
HumansAnimalsCells
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Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. Learn Mem. 2009 Feb; 16(2):147-54.
Jessberger S, Clark RE, Broadbent NJ, Clemenson GD, Consiglio A, Lie DC, Squire LR, Gage FH. PMID: 19181621; PMCID: PMC2661246.
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PubMed Mentions:
315 Fields:
Translation:
AnimalsCells
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Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. J Neurosci. 2009 Jan 28; 29(4):1115-25.
Rose JB, Crews L, Rockenstein E, Adame A, Mante M, Hersh LB, Gage FH, Spencer B, Potkar R, Marr RA, Masliah E. PMID: 19176820; PMCID: PMC2768399.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells. Nat Struct Mol Biol. 2009 Feb; 16(2):130-7.
Yeo GW, Coufal NG, Liang TY, Peng GE, Fu XD, Gage FH. PMID: 19136955; PMCID: PMC2735254.
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PubMed Mentions:
345 Fields:
Translation:
HumansCells
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Fate plasticity of adult hippocampal progenitors: biological relevance and therapeutic use. Trends Pharmacol Sci. 2009 Feb; 30(2):61-5.
Jessberger S, Gage FH. PMID: 19135265; PMCID: PMC2752320.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Development of a novel mouse glioma model using lentiviral vectors. Nat Med. 2009 Jan; 15(1):110-6.
Marumoto T, Tashiro A, Friedmann-Morvinski D, Scadeng M, Soda Y, Gage FH, Verma IM. PMID: 19122659; PMCID: PMC2671237.
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PubMed Mentions:
182 Fields:
Translation:
HumansAnimalsCells
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Development of neural circuits in the adult hippocampus. Curr Top Dev Biol. 2009; 87:149-74.
Li Y, Mu Y, Gage FH. PMID: 19427519.
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PubMed Mentions:
51 Fields:
Translation:
AnimalsCells
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Signaling in adult neurogenesis. Annu Rev Cell Dev Biol. 2009; 25:253-75.
Suh H, Deng W, Gage FH. PMID: 19575663.
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PubMed Mentions:
164 Fields:
Translation:
HumansAnimalsCells
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Genomic anatomy of the hippocampus. Neuron. 2008 Dec 26; 60(6):1010-21.
Thompson CL, Pathak SD, Jeromin A, Ng LL, MacPherson CR, Mortrud MT, Cusick A, Riley ZL, Sunkin SM, Bernard A, Puchalski RB, Gage FH, Jones AR, Bajic VB, Hawrylycz MJ, Lein ES. PMID: 19109908.
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PubMed Mentions:
176 Fields:
Translation:
Animals
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Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell. 2008 Dec 04; 3(6):649-57.
Marchetto MC, Muotri AR, Mu Y, Smith AM, Cezar GG, Gage FH. PMID: 19041781.
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PubMed Mentions:
247 Fields:
Translation:
HumansAnimalsCells
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Stem-cell-associated structural and functional plasticity in the aging hippocampus. Psychol Aging. 2008 Dec; 23(4):684-91.
Jessberger S, Gage FH. PMID: 19140640; PMCID: PMC2771615.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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YAP regulates neural progenitor cell number via the TEA domain transcription factor. Genes Dev. 2008 Dec 01; 22(23):3320-34.
Cao X, Pfaff SL, Gage FH. PMID: 19015275; PMCID: PMC2600760.
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PubMed Mentions:
221 Fields:
Translation:
HumansAnimalsCells
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Epigenetic regulation of neural cell differentiation plasticity in the adult mammalian brain. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):18012-7.
Kohyama J, Kojima T, Takatsuka E, Yamashita T, Namiki J, Hsieh J, Gage FH, Namihira M, Okano H, Sawamoto K, Nakashima K. PMID: 19004774; PMCID: PMC2584744.
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PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
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Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. BMC Neurosci. 2008 Nov 12; 9:109.
Spencer B, Marr RA, Rockenstein E, Crews L, Adame A, Potkar R, Patrick C, Gage FH, Verma IM, Masliah E. PMID: 19014502; PMCID: PMC2596170.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus. PLoS Biol. 2008 Nov 11; 6(11):e272.
Jessberger S, Aigner S, Clemenson GD, Toni N, Lie DC, Karalay O, Overall R, Kempermann G, Gage FH. PMID: 18998770; PMCID: PMC2581629.
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PubMed Mentions:
65 Fields:
Translation:
HumansAnimalsCells
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Experts provide insights into emerging field of brain and spine repair. Interview by Bridget M. Kuehn. JAMA. 2008 Sep 03; 300(9):1013-4.
Gage FH, Selzer ME. PMID: 18768407.
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HumansAnimalsCells
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Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. J Biol Chem. 2008 Oct 10; 283(41):27644-27652.
Li X, Barkho BZ, Luo Y, Smrt RD, Santistevan NJ, Liu C, Kuwabara T, Gage FH, Zhao X. PMID: 18689796; PMCID: PMC2562066.
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PubMed Mentions:
60 Fields:
Translation:
AnimalsCells
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Neurons born in the adult dentate gyrus form functional synapses with target cells. Nat Neurosci. 2008 Aug; 11(8):901-7.
Toni N, Laplagne DA, Zhao C, Lombardi G, Ribak CE, Gage FH, Schinder AF. PMID: 18622400; PMCID: PMC2572641.
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PubMed Mentions:
342 Fields:
Translation:
HumansAnimalsCells
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Directed differentiation of hippocampal stem/progenitor cells in the adult brain. Nat Neurosci. 2008 Aug; 11(8):888-93.
Jessberger S, Toni N, Clemenson GD, Ray J, Gage FH. PMID: 18587391; PMCID: PMC2795354.
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PubMed Mentions:
125 Fields:
Translation:
AnimalsCells
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Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic stem cells. Hum Mol Genet. 2008 Apr 15; 17(R1):R67-75.
Yeo GW, Coufal N, Aigner S, Winner B, Scolnick JA, Marchetto MC, Muotri AR, Carson C, Gage FH. PMID: 18632700.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Mechanisms and functional implications of adult neurogenesis. Cell. 2008 Feb 22; 132(4):645-60.
Zhao C, Deng W, Gage FH. PMID: 18295581.
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PubMed Mentions:
1361 Fields:
Translation:
HumansAnimalsCells
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A role for adult TLX-positive neural stem cells in learning and behaviour. Nature. 2008 Feb 21; 451(7181):1004-7.
Zhang CL, Zou Y, He W, Gage FH, Evans RM. PMID: 18235445.
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PubMed Mentions:
253 Fields:
Translation:
AnimalsCells
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Identification of small molecules from human embryonic stem cells using metabolomics. Stem Cells Dev. 2007 Dec; 16(6):869-82.
Cezar GG, Quam JA, Smith AM, Rosa GJ, Piekarczyk MS, Brown JF, Gage FH, Muotri AR. PMID: 18042039.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. Cell Stem Cell. 2007 Nov; 1(5):515-28.
Suh H, Consiglio A, Ray J, Sawai T, D'Amour KA, Gage FH. PMID: 18371391; PMCID: PMC2185820.
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PubMed Mentions:
377 Fields:
Translation:
AnimalsCells
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The necessary junk: new functions for transposable elements. Hum Mol Genet. 2007 Oct 15; 16 Spec No. 2:R159-67.
Muotri AR, Marchetto MC, Coufal NG, Gage FH. PMID: 17911158.
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PubMed Mentions:
61 Fields:
Translation:
HumansAnimalsCells
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Mouse erythrocyte tropomodulin in the brain reported by lacZ knocked-in downstream from the E1 promoter. Gene Expr Patterns. 2007 Dec; 8(1):36-46.
Yao W, Nathanson J, Lian I, Gage FH, Sung LA. PMID: 17920339.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling. J Neurosci. 2007 Aug 29; 27(35):9400-7.
Jessberger S, Zhao C, Toni N, Clemenson GD, Li Y, Gage FH. PMID: 17728453; PMCID: PMC6673128.
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PubMed Mentions:
157 Fields:
Translation:
AnimalsCells
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Alternative splicing events identified in human embryonic stem cells and neural progenitors. PLoS Comput Biol. 2007 Oct; 3(10):1951-67.
Yeo GW, Xu X, Liang TY, Muotri AR, Carson CT, Coufal NG, Gage FH. PMID: 17967047; PMCID: PMC2041973.
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PubMed Mentions:
75 Fields:
Translation:
HumansCells
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The glycans of stem cells. Curr Opin Chem Biol. 2007 Aug; 11(4):373-80.
Lanctot PM, Gage FH, Varki AP. PMID: 17681848; PMCID: PMC2697851.
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PubMed Mentions:
73 Fields:
Translation:
HumansAnimalsCells
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A novel model for an older remodeler: the BAF swap in neurogenesis. Neuron. 2007 Jul 19; 55(2):171-3.
Aigner S, Denli AM, Gage FH. PMID: 17640518.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Epigenetic modulation of seizure-induced neurogenesis and cognitive decline. J Neurosci. 2007 May 30; 27(22):5967-75.
Jessberger S, Nakashima K, Clemenson GD, Mejia E, Mathews E, Ure K, Ogawa S, Sinton CM, Gage FH, Hsieh J. PMID: 17537967; PMCID: PMC6672253.
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PubMed Mentions:
134 Fields:
Translation:
AnimalsCells
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Plant-derived flavanol (-)epicatechin enhances angiogenesis and retention of spatial memory in mice. J Neurosci. 2007 May 30; 27(22):5869-78.
van Praag H, Lucero MJ, Yeo GW, Stecker K, Heivand N, Zhao C, Yip E, Afanador M, Schroeter H, Hammerstone J, Gage FH. PMID: 17537957; PMCID: PMC6672256.
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PubMed Mentions:
117 Fields:
Translation:
Animals
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Similar GABAergic inputs in dentate granule cells born during embryonic and adult neurogenesis. Eur J Neurosci. 2007 May; 25(10):2973-81.
Laplagne DA, Kamienkowski JE, Espósito MS, Piatti VC, Zhao C, Gage FH, Schinder AF. PMID: 17509085.
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PubMed Mentions:
51 Translation:
AnimalsCells
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Synapse formation on neurons born in the adult hippocampus. Nat Neurosci. 2007 Jun; 10(6):727-34.
Toni N, Teng EM, Bushong EA, Aimone JB, Zhao C, Consiglio A, van Praag H, Martone ME, Ellisman MH, Gage FH. PMID: 17486101.
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PubMed Mentions:
279 Fields:
Translation:
AnimalsCells
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LINE-1 retrotransposition in human embryonic stem cells. Hum Mol Genet. 2007 Jul 01; 16(13):1569-77.
Garcia-Perez JL, Marchetto MC, Muotri AR, Coufal NG, Gage FH, O'Shea KS, Moran JV. PMID: 17468180.
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PubMed Mentions:
123 Fields:
Translation:
HumansCells
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Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons. Neurobiol Dis. 2007 Jul; 27(1):77-89.
Smrt RD, Eaves-Egenes J, Barkho BZ, Santistevan NJ, Zhao C, Aimone JB, Gage FH, Zhao X. PMID: 17532643; PMCID: PMC2789309.
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PubMed Mentions:
124 Fields:
Translation:
AnimalsCells
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Neprilysin protects neurons against Abeta peptide toxicity. Brain Res. 2007 Jun 04; 1152:191-200.
El-Amouri SS, Zhu H, Yu J, Gage FH, Verma IM, Kindy MS. PMID: 17459354; PMCID: PMC2020816.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Experience-specific functional modification of the dentate gyrus through adult neurogenesis: a critical period during an immature stage. J Neurosci. 2007 Mar 21; 27(12):3252-9.
Tashiro A, Makino H, Gage FH. PMID: 17376985; PMCID: PMC6672473.
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PubMed Mentions:
223 Fields:
Translation:
AnimalsCells
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An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5638-43.
Pereira AC, Huddleston DE, Brickman AM, Sosunov AA, Hen R, McKhann GM, Sloan R, Gage FH, Brown TR, Small SA. PMID: 17374720; PMCID: PMC1838482.
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PubMed Mentions:
541 Fields:
Translation:
HumansAnimalsCells
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A functional study of miR-124 in the developing neural tube. Genes Dev. 2007 Mar 01; 21(5):531-6.
Cao X, Pfaff SL, Gage FH. PMID: 17344415; PMCID: PMC1820895.
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PubMed Mentions:
169 Fields:
Translation:
AnimalsCells
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Cortical area size dictates performance at modality-specific behaviors. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):4153-8.
Leingärtner A, Thuret S, Kroll TT, Chou SJ, Leasure JL, Gage FH, O'Leary DD. PMID: 17360492; PMCID: PMC1820724.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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Estradiol enhances neurogenesis following ischemic stroke through estrogen receptors alpha and beta. J Comp Neurol. 2007 Feb 20; 500(6):1064-75.
Suzuki S, Gerhold LM, Böttner M, Rau SW, Dela Cruz C, Yang E, Zhu H, Yu J, Cashion AB, Kindy MS, Merchenthaler I, Gage FH, Wise PM. PMID: 17183542.
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PubMed Mentions:
73 Fields:
Translation:
AnimalsCells
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Is neurogenesis reparative after status epilepticus? Epilepsia. 2007; 48 Suppl 8:69-71.
Parent JM, Jessberger S, Gage FH, Gong C. PMID: 18330005.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Spontaneous fusion and nonclonal growth of adult neural stem cells. Stem Cells. 2007 Apr; 25(4):871-4.
Jessberger S, Clemenson GD, Gage FH. PMID: 17185607.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51):19546-51.
Miller TM, Kim SH, Yamanaka K, Hester M, Umapathi P, Arnson H, Rizo L, Mendell JR, Gage FH, Cleveland DW, Kaspar BK. PMID: 17164329; PMCID: PMC1748262.
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PubMed Mentions:
79 Fields:
Translation:
HumansAnimalsCells
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Integration of new neurons into functional neural networks. J Neurosci. 2006 Nov 22; 26(47):12237-41.
Ramirez-Amaya V, Marrone DF, Gage FH, Worley PF, Barnes CA. PMID: 17122048; PMCID: PMC6675440.
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PubMed Mentions:
145 Fields:
Translation:
AnimalsCells
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Ex vivo and in vivo gene delivery to the brain. Curr Protoc Hum Genet. 2006 Nov; Chapter 13:Unit 13.3.
Suhonen J, Ray J, Blömer U, Gage FH, Kaspar B. PMID: 18428389.
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PubMed Mentions:
6 Fields:
Translation:
Animals
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Stem cells: the good, bad and barely in control. Nat Med. 2006 Nov; 12(11):1237-8.
Carson CT, Aigner S, Gage FH. PMID: 17088886.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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Functional convergence of neurons generated in the developing and adult hippocampus. PLoS Biol. 2006 Nov; 4(12):e409.
Laplagne DA, Espósito MS, Piatti VC, Morgenstern NA, Zhao C, van Praag H, Gage FH, Schinder AF. PMID: 17121455; PMCID: PMC1637132.
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PubMed Mentions:
164 Fields:
Translation:
AnimalsCells
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Fate of endogenous stem/progenitor cells following spinal cord injury. J Comp Neurol. 2006 Oct 01; 498(4):525-38.
Horky LL, Galimi F, Gage FH, Horner PJ. PMID: 16874803; PMCID: PMC2553041.
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PubMed Mentions:
112 Fields:
Translation:
AnimalsCells
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NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus. Nature. 2006 Aug 24; 442(7105):929-33.
Tashiro A, Sandler VM, Toni N, Zhao C, Gage FH. PMID: 16906136.
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PubMed Mentions:
305 Fields:
Translation:
AnimalsCells
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New regulators in adult neurogenesis and their potential role for repair. Trends Mol Med. 2006 Sep; 12(9):400-5.
Jagasia R, Song H, Gage FH, Lie DC. PMID: 16890023.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Therapeutic interventions after spinal cord injury. Nat Rev Neurosci. 2006 Aug; 7(8):628-43.
Thuret S, Moon LD, Gage FH. PMID: 16858391.
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PubMed Mentions:
357 Fields:
Translation:
HumansAnimals
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Functional and morphological effects of NG2 proteoglycan deletion on hippocampal neurogenesis. Exp Neurol. 2006 Nov; 202(1):167-78.
Thallmair M, Ray J, Stallcup WB, Gage FH. PMID: 16814771.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Generation of neuronal variability and complexity. Nature. 2006 Jun 29; 441(7097):1087-93.
Muotri AR, Gage FH. PMID: 16810244.
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PubMed Mentions:
110 Fields:
Translation:
HumansAnimalsCells
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Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10294-10299.
Suzuki A, Raya Á, Kawakami Y, Morita M, Matsui T, Nakashima K, Gage FH, Rodríguez-Esteban C, Izpisúa Belmonte JC. PMID: 16801560; PMCID: PMC1502451.
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PubMed Mentions:
94 Fields:
Translation:
AnimalsCells
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Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. Stem Cells Dev. 2006 Jun; 15(3):407-21.
Barkho BZ, Song H, Aimone JB, Smrt RD, Kuwabara T, Nakashima K, Gage FH, Zhao X. PMID: 16846377; PMCID: PMC2777811.
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PubMed Mentions:
131 Fields:
Translation:
HumansAnimalsCells
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Potential role for adult neurogenesis in the encoding of time in new memories. Nat Neurosci. 2006 Jun; 9(6):723-7.
Aimone JB, Wiles J, Gage FH. PMID: 16732202.
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PubMed Mentions:
276 Fields:
Translation:
HumansAnimalsCells
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Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1. Genes Dev. 2006 May 15; 20(10):1308-20.
Zhang CL, Zou Y, Yu RT, Gage FH, Evans RM. PMID: 16702404; PMCID: PMC1472905.
View in:
PubMed Mentions:
81 Fields:
Translation:
AnimalsCells
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Maintenance of embryonic stem cell pluripotency by Nanog-mediated reversal of mesoderm specification. Nat Clin Pract Cardiovasc Med. 2006 Mar; 3 Suppl 1:S114-22.
Suzuki A, Raya A, Kawakami Y, Morita M, Matsui T, Nakashima K, Gage FH, Rodríguez-Esteban C, Izpisúa Belmonte JC. PMID: 16501617.
View in:
PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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Retinoic acid is required early during adult neurogenesis in the dentate gyrus. Proc Natl Acad Sci U S A. 2006 Mar 07; 103(10):3902-7.
Jacobs S, Lie DC, DeCicco KL, Shi Y, DeLuca LM, Gage FH, Evans RM. PMID: 16505366; PMCID: PMC1450163.
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PubMed Mentions:
114 Fields:
Translation:
AnimalsCells
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Endogenous neurogenesis replaces oligodendrocytes and astrocytes after primate spinal cord injury. J Neurosci. 2006 Feb 22; 26(8):2157-66.
Yang H, Lu P, McKay HM, Bernot T, Keirstead H, Steward O, Gage FH, Edgerton VR, Tuszynski MH. PMID: 16495442; PMCID: PMC6674802.
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PubMed Mentions:
65 Fields:
Translation:
AnimalsCells
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Differential properties of adult rat and mouse brain-derived neural stem/progenitor cells. Mol Cell Neurosci. 2006 Mar; 31(3):560-73.
Ray J, Gage FH. PMID: 16426857.
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PubMed Mentions:
85 Fields:
Translation:
AnimalsCells
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A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells. Angew Chem Int Ed Engl. 2006 Jan 16; 45(4):591-3.
Warashina M, Min KH, Kuwabara T, Huynh A, Gage FH, Schultz PG, Ding S. PMID: 16323231.
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PubMed Mentions:
23 Fields:
Translation:
HumansCells
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Unconventional translation of mammalian LINE-1 retrotransposons. Genes Dev. 2006 Jan 15; 20(2):210-24.
Alisch RS, Garcia-Perez JL, Muotri AR, Gage FH, Moran JV. PMID: 16418485; PMCID: PMC1356112.
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PubMed Mentions:
107 Fields:
Translation:
HumansAnimalsCells
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Natural variation and genetic covariance in adult hippocampal neurogenesis. Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3):780-5.
Kempermann G, Chesler EJ, Lu L, Williams RW, Gage FH. PMID: 16407118; PMCID: PMC1325968.
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PubMed Mentions:
94 Fields:
Translation:
AnimalsCells
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Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus. J Neurosci. 2006 Jan 04; 26(1):3-11.
Zhao C, Teng EM, Summers RG, Ming GL, Gage FH. PMID: 16399667; PMCID: PMC6674324.
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PubMed Mentions:
589 Fields:
Translation:
HumansAnimalsCells
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Neurogenic niche modulation by activated microglia: transforming growth factor beta increases neurogenesis in the adult dentate gyrus. Eur J Neurosci. 2006 Jan; 23(1):83-93.
Battista D, Ferrari CC, Gage FH, Pitossi FJ. PMID: 16420418.
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PubMed Mentions:
131 Translation:
AnimalsCells
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Retrovirus-mediated single-cell gene knockout technique in adult newborn neurons in vivo. Nat Protoc. 2006; 1(6):3049-55.
Tashiro A, Zhao C, Gage FH. PMID: 17406567.
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PubMed Mentions:
78 Fields:
Translation:
AnimalsCells
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Noncoding RNAs in the mammalian central nervous system. Annu Rev Neurosci. 2006; 29:77-103.
Cao X, Yeo G, Muotri AR, Kuwabara T, Gage FH. PMID: 16776580.
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PubMed Mentions:
210 Fields:
Translation:
HumansAnimalsCells
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Motor enrichment sustains hindlimb movement recovered after spinal cord injury and glial transplantation. Restor Neurol Neurosci. 2006; 24(3):147-61.
Moon LD, Leasure JL, Gage FH, Bunge MB. PMID: 16873970.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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In vivo evidence for radial migration of neurons by long-distance somal translocation in the developing ferret visual cortex. Cereb Cortex. 2006 Nov; 16(11):1571-83.
Borrell V, Kaspar BK, Gage FH, Callaway EM. PMID: 16357334.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Development of functional human embryonic stem cell-derived neurons in mouse brain. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18644-8.
Muotri AR, Nakashima K, Toni N, Sandler VM, Gage FH. PMID: 16352714; PMCID: PMC1317971.
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PubMed Mentions:
63 Fields:
Translation:
HumansAnimalsCells
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Wnt signalling regulates adult hippocampal neurogenesis. Nature. 2005 Oct 27; 437(7063):1370-5.
Lie DC, Colamarino SA, Song HJ, Désiré L, Mira H, Consiglio A, Lein ES, Jessberger S, Lansford H, Dearie AR, Gage FH. PMID: 16251967.
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PubMed Mentions:
688 Fields:
Translation:
AnimalsCells
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Chromatin remodeling in neural development and plasticity. Curr Opin Cell Biol. 2005 Dec; 17(6):664-71.
Hsieh J, Gage FH. PMID: 16226449.
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PubMed Mentions:
86 Fields:
Translation:
Cells
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Neuronal and glial cell biology. Curr Opin Neurobiol. 2005 Oct; 15(5):497-9.
Gage FH, McAllister AK. PMID: 16143511.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Regulatable acetylcholine-producing fibroblasts enhance cognitive performance. Mol Ther. 2006 Jan; 13(1):175-82.
Pizzo DP, Coufal NG, Lortie MJ, Gage FH, Thal LJ. PMID: 16185935.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci. 2005 Sep 21; 25(38):8680-5.
van Praag H, Shubert T, Zhao C, Gage FH. PMID: 16177036; PMCID: PMC1360197.
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PubMed Mentions:
837 Fields:
Translation:
AnimalsCells
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Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):14069-74.
Cummings BJ, Uchida N, Tamaki SJ, Salazar DL, Hooshmand M, Summers R, Gage FH, Anderson AJ. PMID: 16172374; PMCID: PMC1216836.
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PubMed Mentions:
296 Fields:
Translation:
HumansAnimalsCells
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Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nat Neurosci. 2005 Oct; 8(10):1343-9.
Singer O, Marr RA, Rockenstein E, Crews L, Coufal NG, Gage FH, Verma IM, Masliah E. PMID: 16136043.
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PubMed Mentions:
167 Fields:
Translation:
HumansAnimalsCells
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Targeted expression of IGF-1 in the central nervous system fails to protect mice from experimental autoimmune encephalomyelitis. J Neuroimmunol. 2005 Nov; 168(1-2):40-5.
Genoud S, Maricic I, Kumar V, Gage FH. PMID: 16120466.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Proliferation, migration, neuronal differentiation, and long-term survival of new cells in the adult zebrafish brain. J Comp Neurol. 2005 Aug 01; 488(3):290-319.
Zupanc GK, Hinsch K, Gage FH. PMID: 15952170.
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PubMed Mentions:
112 Fields:
Translation:
AnimalsCells
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A small gem with great powers: geminin keeps neural progenitors thriving. Dev Cell. 2005 Aug; 9(2):171-2.
Aigner S, Gage FH. PMID: 16054024.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition. Nature. 2005 Jun 16; 435(7044):903-10.
Muotri AR, Chu VT, Marchetto MC, Deng W, Moran JV, Gage FH. PMID: 15959507.
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PubMed Mentions:
478 Fields:
Translation:
HumansAnimalsCells
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Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism. Neuron. 2005 May 19; 46(4):569-79.
Lin W, Dominguez B, Yang J, Aryal P, Brandon EP, Gage FH, Lee KF. PMID: 15944126.
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PubMed Mentions:
106 Fields:
Translation:
AnimalsCells
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Virus-delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis. Ann Neurol. 2005 May; 57(5):773-6.
Miller TM, Kaspar BK, Kops GJ, Yamanaka K, Christian LJ, Gage FH, Cleveland DW. PMID: 15852369; PMCID: PMC1351126.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
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Synergy of insulin-like growth factor-1 and exercise in amyotrophic lateral sclerosis. Ann Neurol. 2005 May; 57(5):649-55.
Kaspar BK, Frost LM, Christian L, Umapathi P, Gage FH. PMID: 15852403.
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PubMed Mentions:
65 Fields:
Translation:
HumansAnimalsCells
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Redefining the boundaries of the hippocampal CA2 subfield in the mouse using gene expression and 3-dimensional reconstruction. J Comp Neurol. 2005 Apr 25; 485(1):1-10.
Lein ES, Callaway EM, Albright TD, Gage FH. PMID: 15776443.
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PubMed Mentions:
68 Fields:
Translation:
Animals
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Quantitative analysis of gene expression in living adult neural stem cells by gene trapping. Nat Methods. 2005 May; 2(5):363-70.
Scheel JR, Ray J, Gage FH, Barlow C. PMID: 15846364.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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DNA repair proteins affect the lifecycle of herpes simplex virus 1. Proc Natl Acad Sci U S A. 2005 Apr 19; 102(16):5844-9.
Lilley CE, Carson CT, Muotri AR, Gage FH, Weitzman MD. PMID: 15824307; PMCID: PMC556126.
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PubMed Mentions:
159 Fields:
Translation:
HumansAnimalsCells
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Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits. Neuron. 2005 Apr 07; 46(1):37-49.
Myers CP, Lewcock JW, Hanson MG, Gosgnach S, Aimone JB, Gage FH, Lee KF, Landmesser LT, Pfaff SL. PMID: 15820692.
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PubMed Mentions:
59 Fields:
Translation:
AnimalsCells
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Human embryonic stem cells express an immunogenic nonhuman sialic acid. Nat Med. 2005 Feb; 11(2):228-32.
Martin MJ, Muotri A, Gage F, Varki A. PMID: 15685172.
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PubMed Mentions:
282 Fields:
Translation:
HumansAnimalsCells
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The NRSE smRNA specifies the fate of adult hippocampal neural stem cells. Nucleic Acids Symp Ser (Oxf). 2005; (49):87-8.
Kuwabara T, Hsieh J, Nakashima K, Warashina M, Taira K, Gage FH. PMID: 17150646.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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An antiaggregation gene therapy strategy for Lewy body disease utilizing beta-synuclein lentivirus in a transgenic model. Gene Ther. 2004 Dec; 11(23):1713-23.
Hashimoto M, Rockenstein E, Mante M, Crews L, Bar-On P, Gage FH, Marr R, Masliah E. PMID: 15483670.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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A role for bone marrow-derived cells in the vasculature of noninjured CNS. Blood. 2005 Mar 15; 105(6):2400-2.
Galimi F, Summers RG, van Praag H, Verma IM, Gage FH. PMID: 15572598.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Intracerebral transplantation of adult mouse neural progenitor cells into the Niemann-Pick-A mouse leads to a marked decrease in lysosomal storage pathology. J Neurosci. 2004 Nov 24; 24(47):10642-51.
Shihabuddin LS, Numan S, Huff MR, Dodge JC, Clarke J, Macauley SL, Yang W, Taksir TV, Parsons G, Passini MA, Gage FH, Stewart GR. PMID: 15564580; PMCID: PMC6730128.
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PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells. Proc Natl Acad Sci U S A. 2004 Nov 23; 101(47):16659-64.
Hsieh J, Nakashima K, Kuwabara T, Mejia E, Gage FH. PMID: 15537713; PMCID: PMC527137.
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PubMed Mentions:
307 Fields:
Translation:
AnimalsCells
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Microfabricated platform for studying stem cell fates. Biotechnol Bioeng. 2004 Nov 05; 88(3):399-415.
Chin VI, Taupin P, Sanga S, Scheel J, Gage FH, Bhatia SN. PMID: 15486946.
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PubMed Mentions:
49 Fields:
Translation:
HumansCells
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Robust in vivo gene transfer into adult mammalian neural stem cells by lentiviral vectors. Proc Natl Acad Sci U S A. 2004 Oct 12; 101(41):14835-40.
Consiglio A, Gritti A, Dolcetta D, Follenzi A, Bordignon C, Gage FH, Vescovi AL, Naldini L. PMID: 15466696; PMCID: PMC522006.
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PubMed Mentions:
51 Fields:
Translation:
AnimalsCells
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A hypothesis about the role of adult neurogenesis in hippocampal function. Physiology (Bethesda). 2004 Oct; 19:253-61.
Schinder AF, Gage FH. PMID: 15381753.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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Epigenetic control of neural stem cell fate. Curr Opin Genet Dev. 2004 Oct; 14(5):461-9.
Hsieh J, Gage FH. PMID: 15380235.
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PubMed Mentions:
91 Fields:
Translation:
AnimalsCells
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Optimizing donor heart outcome after prolonged storage with endothelial function analysis and continuous perfusion. Ann Thorac Surg. 2004 Oct; 78(4):1362-70;; discussion 1362-70.
Poston RS, Gu J, Prastein D, Gage F, Hoffman JW, Kwon M, Azimzadeh A, Pierson RN, Griffith BP. PMID: 15464500.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Cell fusion-independent differentiation of neural stem cells to the endothelial lineage. Nature. 2004 Jul 15; 430(6997):350-6.
Wurmser AE, Nakashima K, Summers RG, Toni N, D'Amour KA, Lie DC, Gage FH. PMID: 15254537.
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PubMed Mentions:
117 Fields:
Translation:
HumansAnimalsCells
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Long-term production of choline acetyltransferase in the CNS after transplantation of fibroblasts modified with a regulatable vector. Brain Res Mol Brain Res. 2004 Jul 05; 126(1):1-13.
Pizzo DP, Paban V, Coufal NG, Gage FH, Thal LJ. PMID: 15207910.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Choline transporter 1 maintains cholinergic function in choline acetyltransferase haploinsufficiency. J Neurosci. 2004 Jun 16; 24(24):5459-66.
Brandon EP, Mellott T, Pizzo DP, Coufal N, D'Amour KA, Gobeske K, Lortie M, López-Coviella I, Berse B, Thal LJ, Gage FH, Blusztajn JK. PMID: 15201317; PMCID: PMC6729318.
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PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
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Structural plasticity of the adult brain. Dialogues Clin Neurosci. 2004 Jun; 6(2):135-41.
Gage FH. PMID: 22034393; PMCID: PMC3181802.
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PubMed Mentions:
9 Fields:
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Unbiased characterization of high-density oligonucleotide microarrays using probe-level statistics. J Neurosci Methods. 2004 May 30; 135(1-2):27-33.
Aimone JB, Gage FH. PMID: 15020086.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Neuroscience. Cellular interactions in the stem cell niche. Science. 2004 May 28; 304(5675):1253-5.
Wurmser AE, Palmer TD, Gage FH. PMID: 15166350.
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PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
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Defining a molecular atlas of the hippocampus using DNA microarrays and high-throughput in situ hybridization. J Neurosci. 2004 Apr 14; 24(15):3879-89.
Lein ES, Zhao X, Gage FH. PMID: 15084669; PMCID: PMC6729356.
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PubMed Mentions:
133 Fields:
Translation:
Animals
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Functional significance of adult neurogenesis. Curr Opin Neurobiol. 2004 Apr; 14(2):186-91.
Kempermann G, Wiskott L, Gage FH. PMID: 15082323.
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PubMed Mentions:
207 Fields:
Translation:
HumansAnimalsCells
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Novel neuronal phenotypes from neural progenitor cells. J Neurosci. 2004 Mar 24; 24(12):2886-97.
Markakis EA, Palmer TD, Randolph-Moore L, Rakic P, Gage FH. PMID: 15044527; PMCID: PMC3242437.
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PubMed Mentions:
53 Fields:
Translation:
AnimalsCells
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A small modulatory dsRNA specifies the fate of adult neural stem cells. Cell. 2004 Mar 19; 116(6):779-93.
Kuwabara T, Hsieh J, Nakashima K, Taira K, Gage FH. PMID: 15035981.
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PubMed Mentions:
145 Fields:
Translation:
HumansAnimalsCells
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IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes. J Cell Biol. 2004 Jan 05; 164(1):111-22.
Hsieh J, Aimone JB, Kaspar BK, Kuwabara T, Nakashima K, Gage FH. PMID: 14709544; PMCID: PMC2171962.
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PubMed Mentions:
141 Fields:
Translation:
AnimalsCells
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Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature. 2004 Jan 01; 427(6969):78-83.
Shi Y, Chichung Lie D, Taupin P, Nakashima K, Ray J, Yu RT, Gage FH, Evans RM. PMID: 14702088.
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PubMed Mentions:
196 Fields:
Translation:
AnimalsCells
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Embryonic stem cells: staying plastic on plastic. Nat Med. 2004 Jan; 10(1):23-4.
Nakashima K, Colamarino S, Gage FH. PMID: 14702626.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Neurogenesis in the adult brain: new strategies for central nervous system diseases. Annu Rev Pharmacol Toxicol. 2004; 44:399-421.
Lie DC, Song H, Colamarino SA, Ming GL, Gage FH. PMID: 14744252.
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PubMed Mentions:
198 Fields:
Translation:
HumansAnimalsCells
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Neurogenesis and neuroadaptation. Neuromolecular Med. 2004; 5(1):1-9.
Schaffer DV, Gage FH. PMID: 15001808.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo. Neuroscience. 2004; 124(1):71-9.
Farmer J, Zhao X, van Praag H, Wodtke K, Gage FH, Christie BR. PMID: 14960340.
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PubMed Mentions:
273 Fields:
Translation:
AnimalsCells