Amanda Lewis

Title(s)	Professor, Ob/Gyn & Reproductive sciences
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

Research Activities and Funding

Roles of vaginal bacteria in bladder exfoliation and recurrent UTI
NIH R21AI152049Feb 20, 2020 - Jan 31, 2022
Role: Principal Investigator

Roles of sialidase in G. vaginalis-host interactions during bacterial vaginosis
NIH R01AI114635Dec 1, 2014 - Nov 30, 2024
Role: Principal Investigator

ROLE OF GBS CAPSULE IN ASCENDING E. COLI UTI & UROSEPSIS IN AGED MULTIPAROUS MICE
NIH R21DK092586Sep 17, 2012 - Aug 30, 2015
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Models of Murine Vaginal Colonization by Anaerobically Grown Bacteria. J Vis Exp. 2022 May 25; (183). Morrill SR, Agarwal K, Saha S, Lewis WG, Gilbert NM, Lewis AL. PMID: 35695538.

View in: PubMed Mentions:
Bladder Exposure to Gardnerella Activates Host Pathways Necessary for Escherichia coli Recurrent UTI. Front Cell Infect Microbiol. 2021; 11:788229. O'Brien VP, Lewis AL, Gilbert NM. PMID: 34938672; PMCID: PMC8685330.

View in: PubMed Mentions:
A mouse model displays host and bacterial strain differences in Aerococcus urinae urinary tract infection. Biol Open. 2021 08 15; 10(8). Gilbert NM, Choi B, Du J, Collins C, Lewis AL, Putonti C, Wolfe AJ. PMID: 34387311; PMCID: PMC8380466.

View in: PubMed Mentions:
Vaginal sialoglycan foraging by Gardnerella vaginalis: mucus barriers as a meal for unwelcome guests? Glycobiology. 2021 06 29; 31(6):667-680. Agarwal K, Lewis AL. PMID: 33825850; PMCID: PMC8252861.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry
The structure and diversity of strain-level variation in vaginal bacteria. Microb Genom. 2021 03; 7(3). Tortelli BA, Lewis AL, Fay JC. PMID: 33656436; PMCID: PMC8190618.

View in: PubMed Mentions:
Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice. J Vis Exp. 2020 12 04; (166). O'Brien VP, Joens MS, Lewis AL, Gilbert NM. PMID: 33346201; PMCID: PMC8034409.

View in: PubMed Mentions: 1 Fields:
Bio Biology Med Medicine (General)
Translation:Animals Cells
Gardnerella vaginalis promotes group B Streptococcus vaginal colonization, enabling ascending uteroplacental infection in pregnant mice. Am J Obstet Gynecol. 2021 05; 224(5):530.e1-530.e17. Gilbert NM, Foster LR, Cao B, Yin Y, Mysorekar IU, Lewis AL. PMID: 33248136; PMCID: PMC8555936.

View in: PubMed Mentions: 1 Fields:
Gyn Gynecology Obs Obstetrics
Translation:Animals Cells
Glycan cross-feeding supports mutualism between Fusobacterium and the vaginal microbiota. PLoS Biol. 2020 08; 18(8):e3000788. Agarwal K, Robinson LS, Aggarwal S, Foster LR, Hernandez-Leyva A, Lin H, Tortelli BA, O'Brien VP, Miller L, Kau AL, Reno H, Gilbert NM, Lewis WG, Lewis AL. PMID: 32841232; PMCID: PMC7447053.

View in: PubMed Mentions: 4 Fields:
Bio Biology
Translation:Humans Animals Cells
Aerococcus urinae Isolated from Women with Lower Urinary Tract Symptoms: In Vitro Aggregation and Genome Analysis. J Bacteriol. 2020 06 09; 202(13). Hilt EE, Putonti C, Thomas-White K, Lewis AL, Visick KL, Gilbert NM, Wolfe AJ. PMID: 32284319; PMCID: PMC7283593.

View in: PubMed Mentions: 4 Fields:
Bac Bacteriology
Translation:Humans Cells
Gardnerella vaginalis as a Cause of Bacterial Vaginosis: Appraisal of the Evidence From in vivo Models. Front Cell Infect Microbiol. 2020; 10:168. Morrill S, Gilbert NM, Lewis AL. PMID: 32391287; PMCID: PMC7193744.

View in: PubMed Mentions: 8 Fields:
Cel Cell Biology Com Communicable Diseases Mic Microbiology
Translation:Humans Animals Cells
USPSTF 2020 Recommendations on Screening for Asymptomatic Bacterial Vaginosis in Pregnancy. JAMA. 2020 04 07; 323(13):1253-1255. Lewis AL, Laurent LC. PMID: 32259215.

View in: PubMed Mentions: 2 Fields:
Med Medicine (General)
Translation:Humans PHPublic Health
Roles of the vagina and the vaginal microbiota in urinary tract infection: evidence from clinical correlations and experimental models. GMS Infect Dis. 2020; 8:Doc02. Lewis AL, Gilbert NM. PMID: 32373427; PMCID: PMC7186798.

View in: PubMed Mentions:
Associations between the vaginal microbiome and Candida colonization in women of reproductive age. Am J Obstet Gynecol. 2020 05; 222(5):471.e1-471.e9. Tortelli BA, Lewis WG, Allsworth JE, Member-Meneh N, Foster LR, Reno HE, Peipert JF, Fay JC, Lewis AL. PMID: 31654610; PMCID: PMC7236091.

View in: PubMed Mentions: 8 Fields:
Gyn Gynecology Obs Obstetrics
Translation:Humans Animals Cells
Gardnerella vaginalis and Prevotella bivia Trigger Distinct and Overlapping Phenotypes in a Mouse Model of Bacterial Vaginosis. J Infect Dis. 2019 08 30; 220(7):1099-1108. Gilbert NM, Lewis WG, Li G, Sojka DK, Lubin JB, Lewis AL. PMID: 30715405; PMCID: PMC6736442.

View in: PubMed Mentions: 20 Fields:
Com Communicable Diseases
Translation:Humans Animals Cells
Low-dose inoculation of Escherichia coli achieves robust vaginal colonization and results in ascending infection accompanied by severe uterine inflammation in mice. PLoS One. 2019; 14(7):e0219941. O'Brien VP, Gilbert NM, Lebratti T, Agarwal K, Foster L, Shin H, Lewis AL. PMID: 31329630; PMCID: PMC6645506.

View in: PubMed Mentions: 3 Fields:
Med Medicine (General)Sci Science
Translation:Animals Cells
Covert pathogenesis: Transient exposures to microbes as triggers of disease. PLoS Pathog. 2019 03; 15(3):e1007586. Gilbert NM, Lewis AL. PMID: 30921443; PMCID: PMC6438445.

View in: PubMed Mentions: 3 Fields:
Mic Microbiology
Translation:Humans Cells
Identification and characterization of NanH2 and NanH3, enzymes responsible for sialidase activity in the vaginal bacterium Gardnerella vaginalis. J Biol Chem. 2019 04 05; 294(14):5230-5245. Robinson LS, Schwebke J, Lewis WG, Lewis AL. PMID: 30723162; PMCID: PMC6462536.

View in: PubMed Mentions: 15 Fields:
Bio Biochemistry
Translation:Humans Cells
Relationship between nugent score and vaginal epithelial exfoliation. PLoS One. 2017; 12(5):e0177797. Amegashie CP, Gilbert NM, Peipert JF, Allsworth JE, Lewis WG, Lewis AL. PMID: 28562623; PMCID: PMC5451030.

View in: PubMed Mentions: 10 Fields:
Med Medicine (General)Sci Science
Translation:Humans Cells
The sialate O-acetylesterase EstA from gut Bacteroidetes species enables sialidase-mediated cross-species foraging of 9-O-acetylated sialoglycans. J Biol Chem. 2017 07 14; 292(28):11861-11872. Robinson LS, Lewis WG, Lewis AL. PMID: 28526748; PMCID: PMC5512079.

View in: PubMed Mentions: 16 Fields:
Bio Biochemistry
Translation:Animals Cells
Human milk oligosaccharides inhibit growth of group B Streptococcus. J Biol Chem. 2017 07 07; 292(27):11243-11249. Lin AE, Autran CA, Szyszka A, Escajadillo T, Huang M, Godula K, Prudden AR, Boons GJ, Lewis AL, Doran KS, Nizet V, Bode L. PMID: 28416607; PMCID: PMC5500792.

View in: PubMed Mentions: 40 Fields:
Bio Biochemistry
Translation:Humans Cells
Transient microbiota exposures activate dormant Escherichia coli infection in the bladder and drive severe outcomes of recurrent disease. PLoS Pathog. 2017 03; 13(3):e1006238. Gilbert NM, O'Brien VP, Lewis AL. PMID: 28358889; PMCID: PMC5373645.

View in: PubMed Mentions: 28 Fields:
Mic Microbiology
Translation:Animals Cells
A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease. Nat Microbiol. 2016 Oct 31; 2:16196. O'Brien VP, Hannan TJ, Yu L, Livny J, Roberson ED, Schwartz DJ, Souza S, Mendelsohn CL, Colonna M, Lewis AL, Hultgren SJ. PMID: 27798558; PMCID: PMC5308540.

View in: PubMed Mentions: 23 Fields:
Mic Microbiology Par Parasitology Vir Virology
Translation:Animals Cells
Genome Sequences of 15 Gardnerella vaginalis Strains Isolated from the Vaginas of Women with and without Bacterial Vaginosis. Genome Announc. 2016 Sep 29; 4(5). Robinson LS, Perry J, Lek S, Wollam A, Sodergren E, Weinstock G, Lewis WG, Lewis AL. PMID: 27688326; PMCID: PMC5043544.

View in: PubMed Mentions: 5
Genome Sequences of 11 Human Vaginal Actinobacteria Strains. Genome Announc. 2016 Sep 29; 4(5). Lewis AL, Deitzler GE, Ruiz MJ, Weimer C, Park S, Robinson LS, Hallsworth-Pepin K, Wollam A, Mitreva M, Lewis WG. PMID: 27688328; PMCID: PMC5043546.

View in: PubMed Mentions: 5
A New Catalog of Microbiological Tools for Women's Infectious Disease Research. Genome Announc. 2016 Sep 29; 4(5). Lewis AL, Lewis WG. PMID: 27688331; PMCID: PMC5043549.

View in: PubMed Mentions:
Discovery and characterization of de novo sialic acid biosynthesis in the phylum Fusobacterium. Glycobiology. 2016 10; 26(10):1107-1119. Lewis AL, Robinson LS, Agarwal K, Lewis WG. PMID: 27613803; PMCID: PMC5072148.

View in: PubMed Mentions: 4 Fields:
Bio Biochemistry
Translation:Cells
Evolutionary inactivation of a sialidase in group B Streptococcus. Sci Rep. 2016 06 29; 6:28852. Yamaguchi M, Hirose Y, Nakata M, Uchiyama S, Yamaguchi Y, Goto K, Sumitomo T, Lewis AL, Kawabata S, Nizet V. PMID: 27352769; PMCID: PMC4926279.

View in: PubMed Mentions: 8 Fields:
Sci Science
Translation:Humans Animals Cells
Host-like carbohydrates promote bloodstream survival of Vibrio vulnificus in vivo. Infect Immun. 2015 Aug; 83(8):3126-36. Lubin JB, Lewis WG, Gilbert NM, Weimer CM, Almagro-Moreno S, Boyd EF, Lewis AL. PMID: 26015477; PMCID: PMC4496609.

View in: PubMed Mentions: 8 Fields:
All Allergy and Immunology Com Communicable Diseases
Translation:Humans Animals Cells
Impact of host age and parity on susceptibility to severe urinary tract infection in a murine model. PLoS One. 2014; 9(5):e97798. Kline KA, Schwartz DJ, Gilbert NM, Lewis AL. PMID: 24835885; PMCID: PMC4024022.

View in: PubMed Mentions: 14 Fields:
Med Medicine (General)Sci Science
Translation:Animals Cells
Urinary tract infection as a preventable cause of pregnancy complications: opportunities, challenges, and a global call to action. Glob Adv Health Med. 2013 Sep; 2(5):59-69. Gilbert NM, O'Brien VP, Hultgren S, Macones G, Lewis WG, Lewis AL. PMID: 24416696; PMCID: PMC3833562.

View in: PubMed Mentions: 23
Clinical features of bacterial vaginosis in a murine model of vaginal infection with Gardnerella vaginalis. PLoS One. 2013; 8(3):e59539. Gilbert NM, Lewis WG, Lewis AL. PMID: 23527214; PMCID: PMC3602284.

View in: PubMed Mentions: 40 Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals Cells
Degradation, foraging, and depletion of mucus sialoglycans by the vagina-adapted Actinobacterium Gardnerella vaginalis. J Biol Chem. 2013 Apr 26; 288(17):12067-79. Lewis WG, Robinson LS, Gilbert NM, Perry JC, Lewis AL. PMID: 23479734; PMCID: PMC3636892.

View in: PubMed Mentions: 46 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Immune modulation by group B Streptococcus influences host susceptibility to urinary tract infection by uropathogenic Escherichia coli. Infect Immun. 2012 Dec; 80(12):4186-94. Kline KA, Schwartz DJ, Gilbert NM, Hultgren SJ, Lewis AL. PMID: 22988014; PMCID: PMC3497425.

View in: PubMed Mentions: 32 Fields:
All Allergy and Immunology Com Communicable Diseases
Translation:Humans Animals Cells
Expression of sialic acids and other nonulosonic acids in Leptospira. BMC Microbiol. 2012 Aug 01; 12:161. Ricaldi JN, Matthias MA, Vinetz JM, Lewis AL. PMID: 22853805; PMCID: PMC3438082.

View in: PubMed Mentions: 10 Fields:
Mic Microbiology
Translation:Cells
Host sialoglycans and bacterial sialidases: a mucosal perspective. Cell Microbiol. 2012 Aug; 14(8):1174-82. Lewis AL, Lewis WG. PMID: 22519819.

View in: PubMed Mentions: 66 Fields:
Cel Cell Biology Mic Microbiology
Translation:Humans Animals Cells
Hydrolysis of secreted sialoglycoprotein immunoglobulin A (IgA) in ex vivo and biochemical models of bacterial vaginosis. J Biol Chem. 2012 Jan 13; 287(3):2079-89. Lewis WG, Robinson LS, Perry J, Bick JL, Peipert JF, Allsworth JE, Lewis AL. PMID: 22134918; PMCID: PMC3265887.

View in: PubMed Mentions: 24 Fields:
Bio Biochemistry
Translation:Humans Cells
Genomic and metabolic profiling of nonulosonic acids in Vibrionaceae reveal biochemical phenotypes of allelic divergence in Vibrio vulnificus. Appl Environ Microbiol. 2011 Aug 15; 77(16):5782-93. Lewis AL, Lubin JB, Argade S, Naidu N, Choudhury B, Boyd EF. PMID: 21724895; PMCID: PMC3165262.

View in: PubMed Mentions: 12 Fields:
Mic Microbiology
Translation:Cells
Immune activation and suppression by group B streptococcus in a murine model of urinary tract infection. Infect Immun. 2011 Sep; 79(9):3588-95. Kline KA, Schwartz DJ, Lewis WG, Hultgren SJ, Lewis AL. PMID: 21690238; PMCID: PMC3165466.

View in: PubMed Mentions: 27 Fields:
All Allergy and Immunology Com Communicable Diseases
Translation:Animals Cells
O-Acetylation of sialic acid on Group B Streptococcus inhibits neutrophil suppression and virulence. Biochem J. 2010 May 13; 428(2):163-8. Weiman S, Uchiyama S, Lin FY, Chaffin D, Varki A, Nizet V, Lewis AL. PMID: 20334627; PMCID: PMC3640289.

View in: PubMed Mentions: 17 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Genetic and biochemical modulation of sialic acid O-acetylation on group B Streptococcus: phenotypic and functional impact. Glycobiology. 2009 Nov; 19(11):1204-13. Weiman S, Dahesh S, Carlin AF, Varki A, Nizet V, Lewis AL. PMID: 19643844; PMCID: PMC2757575.

View in: PubMed Mentions: 22 Fields:
Bio Biochemistry
Translation:Cells
Innovations in host and microbial sialic acid biosynthesis revealed by phylogenomic prediction of nonulosonic acid structure. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13552-7. Lewis AL, Desa N, Hansen EE, Knirel YA, Gordon JI, Gagneux P, Nizet V, Varki A. PMID: 19666579; PMCID: PMC2726416.

View in: PubMed Mentions: 58 Fields:
Sci Science
Translation:Humans Cells
Group B streptococcal conjugate vaccines elicit functional antibodies independent of strain O-acetylation. Vaccine. 2009 Jul 16; 27(33):4452-6. Pannaraj PS, Edwards MS, Ewing KT, Lewis AL, Rench MA, Baker CJ. PMID: 19490960; PMCID: PMC2778198.

View in: PubMed Mentions: 5 Fields:
All Allergy and Immunology
Translation:Humans Cells
Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response. Blood. 2009 Apr 02; 113(14):3333-6. Carlin AF, Uchiyama S, Chang YC, Lewis AL, Nizet V, Varki A. PMID: 19196661; PMCID: PMC2665898.

View in: PubMed Mentions: 158 Fields:
Hem Hematology
Translation:Humans Cells
NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in group B Streptococcus. J Biol Chem. 2007 Sep 21; 282(38):27562-71. Lewis AL, Cao H, Patel SK, Diaz S, Ryan W, Carlin AF, Thon V, Lewis WG, Varki A, Chen X, Nizet V. PMID: 17646166; PMCID: PMC2588433.

View in: PubMed Mentions: 23 Fields:
Bio Biochemistry
Translation:Cells
Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes. J Bacteriol. 2007 Feb; 189(4):1231-7. Carlin AF, Lewis AL, Varki A, Nizet V. PMID: 16997964; PMCID: PMC1797352.

View in: PubMed Mentions: 62 Fields:
Bac Bacteriology
Translation:Humans Animals Cells
The group B streptococcal sialic acid O-acetyltransferase is encoded by neuD, a conserved component of bacterial sialic acid biosynthetic gene clusters. J Biol Chem. 2006 Apr 21; 281(16):11186-92. Lewis AL, Hensler ME, Varki A, Nizet V. PMID: 16490781.

View in: PubMed Mentions: 29 Fields:
Bio Biochemistry
Translation:Cells
A human-specific gene in microglia. Science. 2005 Sep 09; 309(5741):1693. Hayakawa T, Angata T, Lewis AL, Mikkelsen TS, Varki NM, Varki A. PMID: 16151003.

View in: PubMed Mentions: 31 Fields:
Sci Science
Translation:Humans Animals Cells
Combining parenting and a science career. Science. 2005 Mar 18; 307(5716):1720-1. Lewis AL, Altheide TK, Varki A, Arden K, Varki NM. PMID: 15779114.

View in: PubMed Mentions: Fields:
Sci Science
Combining Parenting and a Science Career. Science. 2005 Mar 18; 307(5716):1720b-1721b. Djerassi C, Lewis AL, Altheide TK, Varki A, Arden K, Varki NM, Peekna A. PMID: 15778202.

View in: PubMed Mentions: Fields:
Sci Science
Discovery and characterization of sialic acid O-acetylation in group B Streptococcus. Proc Natl Acad Sci U S A. 2004 Jul 27; 101(30):11123-8. Lewis AL, Nizet V, Varki A. PMID: 15263085; PMCID: PMC503750.

View in: PubMed Mentions: 70 Fields:
Sci Science
Translation:Cells