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Amanda Lewis

Title(s)Professor, Ob/Gyn & Reproductive sciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Roles of vaginal bacteria in bladder exfoliation and recurrent UTI
    NIH/NIAID R21AI152049Feb 20, 2020 - Jan 31, 2022
    Role: Principal Investigator
    Roles of sialidase in G. vaginalis-host interactions during bacterial vaginosis
    NIH/NIAID R01AI114635Dec 1, 2014 - Nov 30, 2024
    Role: Principal Investigator
    ROLE OF GBS CAPSULE IN ASCENDING E. COLI UTI &UROSEPSIS IN AGED MULTIPAROUS MICE
    NIH/NIDDK R21DK092586Sep 17, 2012 - Aug 30, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gardnerella vaginalis promotes group B Streptococcus vaginal colonization, enabling ascending uteroplacental infection in pregnant mice. Am J Obstet Gynecol. 2020 Nov 25. Gilbert NM, Foster LR, Cao B, Yin Y, Mysorekar IU, Lewis AL. PMID: 33248136.
      View in: PubMed   Mentions:    Fields:    
    2. Glycan cross-feeding supports mutualism between Fusobacterium and the vaginal microbiota. PLoS Biol. 2020 08; 18(8):e3000788. Agarwal K, Robinson LS, Aggarwal S, Foster LR, Hernandez-Leyva A, Lin H, Tortelli BA, O'Brien VP, Miller L, Kau AL, Reno H, Gilbert NM, Lewis WG, Lewis AL. PMID: 32841232.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Aerococcus urinae Isolated from Women with Lower Urinary Tract Symptoms: In Vitro Aggregation and Genome Analysis. J Bacteriol. 2020 Jun 09; 202(13). Hilt EE, Putonti C, Thomas-White K, Lewis AL, Visick KL, Gilbert NM, Wolfe AJ. PMID: 32284319.
      View in: PubMed   Mentions:    Fields:    
    4. USPSTF 2020 Recommendations on Screening for Asymptomatic Bacterial Vaginosis in Pregnancy. JAMA. 2020 04 07; 323(13):1253-1255. Lewis AL, Laurent LC. PMID: 32259215.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    5. The sialate O-acetylesterase EstA from gut Bacteroidetes species enables sialidase-mediated cross-species foraging of 9-O-acetylated sialoglycans. J Biol Chem. 2017 07 14; 292(28):11861-11872. Robinson LS, Lewis WG, Lewis AL. PMID: 28526748.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    6. Human milk oligosaccharides inhibit growth of group B Streptococcus. J Biol Chem. 2017 07 07; 292(27):11243-11249. Lin AE, Autran CA, Szyszka A, Escajadillo T, Huang M, Godula K, Prudden AR, Boons GJ, Lewis AL, Doran KS, Nizet V, Bode L. PMID: 28416607.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    7. Genome Sequences of 11 Human Vaginal Actinobacteria Strains. Genome Announc. 2016 Sep 29; 4(5). Lewis AL, Deitzler GE, Ruiz MJ, Weimer C, Park S, Robinson LS, Hallsworth-Pepin K, Wollam A, Mitreva M, Lewis WG. PMID: 27688328.
      View in: PubMed   Mentions:
    8. A New Catalog of Microbiological Tools for Women's Infectious Disease Research. Genome Announc. 2016 Sep 29; 4(5). Lewis AL, Lewis WG. PMID: 27688331.
      View in: PubMed   Mentions:
    9. Discovery and characterization of de novo sialic acid biosynthesis in the phylum Fusobacterium. Glycobiology. 2016 10; 26(10):1107-1119. Lewis AL, Robinson LS, Agarwal K, Lewis WG. PMID: 27613803.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    10. Evolutionary inactivation of a sialidase in group B Streptococcus. Sci Rep. 2016 06 29; 6:28852. Yamaguchi M, Hirose Y, Nakata M, Uchiyama S, Yamaguchi Y, Goto K, Sumitomo T, Lewis AL, Kawabata S, Nizet V. PMID: 27352769.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    11. Host-like carbohydrates promote bloodstream survival of Vibrio vulnificus in vivo. Infect Immun. 2015 Aug; 83(8):3126-36. Lubin JB, Lewis WG, Gilbert NM, Weimer CM, Almagro-Moreno S, Boyd EF, Lewis AL. PMID: 26015477.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    12. Degradation, foraging, and depletion of mucus sialoglycans by the vagina-adapted Actinobacterium Gardnerella vaginalis. J Biol Chem. 2013 Apr 26; 288(17):12067-79. Lewis WG, Robinson LS, Gilbert NM, Perry JC, Lewis AL. PMID: 23479734.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    13. Immune modulation by group B Streptococcus influences host susceptibility to urinary tract infection by uropathogenic Escherichia coli. Infect Immun. 2012 Dec; 80(12):4186-94. Kline KA, Schwartz DJ, Gilbert NM, Hultgren SJ, Lewis AL. PMID: 22988014.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    14. Expression of sialic acids and other nonulosonic acids in Leptospira. BMC Microbiol. 2012 Aug 01; 12:161. Ricaldi JN, Matthias MA, Vinetz JM, Lewis AL. PMID: 22853805.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    15. Host sialoglycans and bacterial sialidases: a mucosal perspective. Cell Microbiol. 2012 Aug; 14(8):1174-82. Lewis AL, Lewis WG. PMID: 22519819.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    16. Hydrolysis of secreted sialoglycoprotein immunoglobulin A (IgA) in ex vivo and biochemical models of bacterial vaginosis. J Biol Chem. 2012 Jan 13; 287(3):2079-89. Lewis WG, Robinson LS, Perry J, Bick JL, Peipert JF, Allsworth JE, Lewis AL. PMID: 22134918.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    17. Genomic and metabolic profiling of nonulosonic acids in Vibrionaceae reveal biochemical phenotypes of allelic divergence in Vibrio vulnificus. Appl Environ Microbiol. 2011 Aug 15; 77(16):5782-93. Lewis AL, Lubin JB, Argade S, Naidu N, Choudhury B, Boyd EF. PMID: 21724895.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    18. Immune activation and suppression by group B streptococcus in a murine model of urinary tract infection. Infect Immun. 2011 Sep; 79(9):3588-95. Kline KA, Schwartz DJ, Lewis WG, Hultgren SJ, Lewis AL. PMID: 21690238.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    19. O-Acetylation of sialic acid on Group B Streptococcus inhibits neutrophil suppression and virulence. Biochem J. 2010 May 13; 428(2):163-8. Weiman S, Uchiyama S, Lin FY, Chaffin D, Varki A, Nizet V, Lewis AL. PMID: 20334627.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    20. Genetic and biochemical modulation of sialic acid O-acetylation on group B Streptococcus: phenotypic and functional impact. Glycobiology. 2009 Nov; 19(11):1204-13. Weiman S, Dahesh S, Carlin AF, Varki A, Nizet V, Lewis AL. PMID: 19643844.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    21. Innovations in host and microbial sialic acid biosynthesis revealed by phylogenomic prediction of nonulosonic acid structure. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13552-7. Lewis AL, Desa N, Hansen EE, Knirel YA, Gordon JI, Gagneux P, Nizet V, Varki A. PMID: 19666579.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    22. Group B streptococcal conjugate vaccines elicit functional antibodies independent of strain O-acetylation. Vaccine. 2009 Jul 16; 27(33):4452-6. Pannaraj PS, Edwards MS, Ewing KT, Lewis AL, Rench MA, Baker CJ. PMID: 19490960.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    23. Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response. Blood. 2009 Apr 02; 113(14):3333-6. Carlin AF, Uchiyama S, Chang YC, Lewis AL, Nizet V, Varki A. PMID: 19196661.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansCells
    24. NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in group B Streptococcus. J Biol Chem. 2007 Sep 21; 282(38):27562-71. Lewis AL, Cao H, Patel SK, Diaz S, Ryan W, Carlin AF, Thon V, Lewis WG, Varki A, Chen X, Nizet V. PMID: 17646166.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    25. Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes. J Bacteriol. 2007 Feb; 189(4):1231-7. Carlin AF, Lewis AL, Varki A, Nizet V. PMID: 16997964.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    26. The group B streptococcal sialic acid O-acetyltransferase is encoded by neuD, a conserved component of bacterial sialic acid biosynthetic gene clusters. J Biol Chem. 2006 Apr 21; 281(16):11186-92. Lewis AL, Hensler ME, Varki A, Nizet V. PMID: 16490781.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    27. A human-specific gene in microglia. Science. 2005 Sep 09; 309(5741):1693. Hayakawa T, Angata T, Lewis AL, Mikkelsen TS, Varki NM, Varki A. PMID: 16151003.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    28. Combining parenting and a science career. Science. 2005 Mar 18; 307(5716):1720-1. Lewis AL, Altheide TK, Varki A, Arden K, Varki NM. PMID: 15779114.
      View in: PubMed   Mentions:    Fields:    
    29. Combining Parenting and a Science Career. Science. 2005 Mar 18; 307(5716):1720b-1721b. Djerassi C, Lewis AL, Altheide TK, Varki A, Arden K, Varki NM, Peekna A. PMID: 15778202.
      View in: PubMed   Mentions:    Fields:    
    30. Discovery and characterization of sialic acid O-acetylation in group B Streptococcus. Proc Natl Acad Sci U S A. 2004 Jul 27; 101(30):11123-8. Lewis AL, Nizet V, Varki A. PMID: 15263085.
      View in: PubMed   Mentions: 65     Fields:    Translation:Cells
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