Dzung Le

Title(s)	Clinical Professor, Pathology
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

Research Activities and Funding

Glycan Modulation of Inflammatory Responses
NIH P01HL107150Jul 1, 2011 - May 31, 2018
Role: Co-Investigator

Genetic Modulation of Blood and Vascular Glycosylation
NIH P01HL057345Sep 30, 1997 - Dec 31, 2013
Role: Co-Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Novel Approach to Improve the Identification of the Bleeding Phenotype in Noonan Syndrome and Related RASopathies. J Pediatr. 2023 06; 257:113323. Bruno L, Lenberg J, Le D, Dimmock D, Thornburg CD, Briggs B. PMID: 36646249.

View in: PubMed Mentions: 2 Fields:
Ped Pediatrics
Translation:Humans
A Novel Hypomorphic Apex1 Mouse Model Implicates Apurinic/Apyrimidinic Endonuclease 1 in Oxidative DNA Damage Repair in Gastric Epithelial Cells. Antioxid Redox Signal. 2023 01; 38(1-3):183-197. Rios-Covian D, Butcher LD, Ablack AL, den Hartog G, Matsubara MT, Ly H, Oates AW, Xu G, Fisch KM, Ahrens ET, Toden S, Brown CC, Kim K, Le D, Eckmann L, Dhar B, Izumi T, Ernst PB, Crowe SE. PMID: 35754343; PMCID: PMC10039277.

View in: PubMed Mentions: Fields:
Met Metabolism
Translation:Animals Cells
Endothelial Heparan Sulfate Mediates Hepatic Neutrophil Trafficking and Injury during Staphylococcus aureus Sepsis. mBio. 2021 10 26; 12(5):e0118121. Golden GJ, Toledo AG, Marki A, Sorrentino JT, Morris C, Riley RJ, Spliid C, Chen Q, Cornax I, Lewis NE, Varki N, Le D, Malmström J, Karlsson C, Ley K, Nizet V, Esko JD. PMID: 34544271; PMCID: PMC8546592.

View in: PubMed Mentions: 4 Fields:
Mic Microbiology
Translation:Animals Cells
The Evaluation of Hematologic Screening and Perioperative Management in Patients with Noonan Syndrome: A Retrospective Chart Review. J Pediatr. 2020 05; 220:154-158.e6. Briggs B, Savla D, Ramchandar N, Dimmock D, Le D, Thornburg CD. PMID: 32111381.

View in: PubMed Mentions: 2 Fields:
Ped Pediatrics
Translation:Humans PHPublic Health
Small molecule antagonists of cell-surface heparan sulfate and heparin-protein interactions. Chem Sci. 2015 Oct 01; 6(10):5984-5993. Weiss RJ, Gordts PL, Le D, Xu D, Esko JD, Tor Y. PMID: 28133533; PMCID: PMC5267326.

View in: PubMed Mentions: 12
A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins. Glycobiology. 2013 Mar; 23(3):363-80. Orr SL, Le D, Long JM, Sobieszczuk P, Ma B, Tian H, Fang X, Paulson JC, Marth JD, Varki N. PMID: 23118208; PMCID: PMC3605971.

View in: PubMed Mentions: 29 Fields:
Bio Biochemistry
Translation:Animals
Systemic mastocytosis in association with chronic lymphocytic leukemia and plasma cell myeloma. Int J Clin Exp Pathol. 2010 Apr 23; 3(4):448-57. Du S, Rashidi HH, Le DT, Kipps TJ, Broome HE, Wang HY. PMID: 20490336; PMCID: PMC2872752.

View in: PubMed Mentions: 3 Fields:
Pat Pathology
Translation:Humans
In vitro sonothrombolysis with duplex ultrasound: first results using a simplified model. Cerebrovasc Dis. 2009; 28(4):365-70. Holscher T, Raman R, Ernström K, Parrish J, Le DT, Lyden PD, Mattrey RF. PMID: 19641311.

View in: PubMed Mentions: 3 Fields:
Bra Brain Vas Vascular Diseases
Translation:Humans
The Ashwell receptor mitigates the lethal coagulopathy of sepsis. Nat Med. 2008 Jun; 14(6):648-55. Grewal PK, Uchiyama S, Ditto D, Varki N, Le DT, Nizet V, Marth JD. PMID: 18488037; PMCID: PMC2853759.

View in: PubMed Mentions: 147 Fields:
Med Medicine (General)Mol Molecular Biology
Translation:Humans Animals Cells
Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity. Mol Cell Biol. 2007 Dec; 27(24):8783-96. Tenno M, Ohtsubo K, Hagen FK, Ditto D, Zarbock A, Schaerli P, von Andrian UH, Ley K, Le D, Tabak LA, Marth JD. PMID: 17923703; PMCID: PMC2169402.

View in: PubMed Mentions: 59 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells PHPublic Health
Selectin-mucin interactions as a probable molecular explanation for the association of Trousseau syndrome with mucinous adenocarcinomas. J Clin Invest. 2003 Sep; 112(6):853-62. Wahrenbrock M, Borsig L, Le D, Varki N, Varki A. PMID: 12975470; PMCID: PMC193671.

View in: PubMed Mentions: 99 Fields:
Med Medicine (General)
Translation:Humans Animals Cells
Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):10042-7. Ellies LG, Ditto D, Levy GG, Wahrenbrock M, Ginsburg D, Varki A, Le DT, Marth JD. PMID: 12097641; PMCID: PMC126621.

View in: PubMed Mentions: 81 Fields:
Sci Science
Translation:Animals Cells
Modeling human congenital disorder of glycosylation type IIa in the mouse: conservation of asparagine-linked glycan-dependent functions in mammalian physiology and insights into disease pathogenesis. Glycobiology. 2001 Dec; 11(12):1051-70. Wang Y, Tan J, Sutton-Smith M, Ditto D, Panico M, Campbell RM, Varki NM, Long JM, Jaeken J, Levinson SR, Wynshaw-Boris A, Morris HR, Le D, Dell A, Schachter H, Marth JD. PMID: 11805078.

View in: PubMed Mentions: 56 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Decrease in the plasma von Willebrand factor concentration following glucose ingestion: the role of insulin sensitivity. Metabolism. 2001 Dec; 50(12):1452-6. von Känel R, Nelesen RA, Le DT, Ziegler MG, Dimsdale JE. PMID: 11735092.

View in: PubMed Mentions: Fields:
Met Metabolism
Translation:Humans
The hypercoagulable state in sleep apnea is related to comorbid hypertension. J Hypertens. 2001 Aug; 19(8):1445-51. von Känel R, Le DT, Nelesen RA, Mills PJ, Ancoli-Israel S, Dimsdale JE. PMID: 11518853.

View in: PubMed Mentions: 12 Fields:
Vas Vascular Diseases
Translation:Humans
Quantitative effects of nefiracetam on spatial learning of rats after cerebral embolism. J Stroke Cerebrovasc Dis. 2001 May-Jun; 10(3):99-105. Le DT, Shin C, Jackson-Friedman C, Lyden PD. PMID: 17903808.

View in: PubMed Mentions: 1 Fields:
Bra Brain Vas Vascular Diseases
A novel clotting assay for quantitation of plasma prothrombin (factor II) using Echis multisquamatus venom. Am J Clin Pathol. 1999 Nov; 112(5):705-11. Petrovan RJ, Rapaport SI, Le DT. PMID: 10549258.

View in: PubMed Mentions: Fields:
Pat Pathology
Translation:Humans Animals
Hemostatic factors in rabbit limb lymph: relationship to mechanisms regulating extravascular coagulation. Am J Physiol. 1998 03; 274(3):H769-76. Le DT, Borgs P, Toneff TW, Witte MH, Rapaport SI. PMID: 9530187.

View in: PubMed Mentions: 13 Fields:
Phy Physiology
Translation:Animals
A Protac-based screening test for activated protein C-resistant factor Va and other defects of the protein C anticoagulant pathway. Blood Coagul Fibrinolysis. 1997 Sep; 8(6):327-35. Gable PS, Le DT, McGehee W, Rapaport SI. PMID: 9351522.

View in: PubMed Mentions: 1 Fields:
Hem Hematology Vas Vascular Diseases
Translation:Humans
Correction of excessive anticoagulation with low-dose oral vitamin K1. Ann Intern Med. 1997 Jun 15; 126(12):959-62. Weibert RT, Le DT, Kayser SR, Rapaport SI. PMID: 9182473.

View in: PubMed Mentions: 15 Fields:
Int Internal Medicine
Translation:Humans
Protac, a commercially available protein C activator from the venom of Agkistrodon contortrix contortrix, can activate factor V and factor VIII. Thromb Res. 1997 Apr 01; 86(1):79-84. Gable PS, Le DT, Rapaport SI. PMID: 9172290.

View in: PubMed Mentions: Fields:
Vas Vascular Diseases
Translation:Humans Animals Cells
Reliability of a modified tissue factor-dependent factor V assay for activated protein C resistant factor Va using a calcium-containing thromboplastin. Thromb Haemost. 1997 Mar; 77(3):481-5. Le DT, Donnelly KJ, Wu N, Sevilla BK, Rapaport SI. PMID: 9065998.

View in: PubMed Mentions: Fields:
Hem Hematology Vas Vascular Diseases
Translation:Humans
A monoclonal IgG anticardiolipin antibody from a patient with the antiphospholipid syndrome is thrombogenic in mice. Proc Natl Acad Sci U S A. 1996 Aug 06; 93(16):8606-11. Olee T, Pierangeli SS, Handley HH, Le DT, Wei X, Lai CJ, En J, Novotny W, Harris EN, Woods VL, Chen PP. PMID: 8710918; PMCID: PMC38720.

View in: PubMed Mentions: 10 Fields:
Sci Science
Translation:Humans Animals
Use of a generally applicable tissue factor--dependent factor V assay to detect activated protein C-resistant factor Va in patients receiving warfarin and in patients with a lupus anticoagulant. Blood. 1995 Apr 01; 85(7):1704-11. Le DT, Griffin JH, Greengard JS, Mujumdar V, Rapaport SI. PMID: 7703480.

View in: PubMed Mentions: 3 Fields:
Hem Hematology
Translation:Humans
Studies of the mechanism for enhanced cell surface factor VIIa/tissue factor activation of factor X on fibroblast monolayers after their exposure to N-ethylmaleimide. Thromb Haemost. 1994 Dec; 72(6):848-55. Le DT, Rapaport SI, Rao LV. PMID: 7740453.

View in: PubMed Mentions: 22 Fields:
Hem Hematology Vas Vascular Diseases
Translation:Humans Cells
The international normalized ratio (INR) for monitoring warfarin therapy: reliability and relation to other monitoring methods. Ann Intern Med. 1994 Apr 01; 120(7):552-8. Le DT, Weibert RT, Sevilla BK, Donnelly KJ, Rapaport SI. PMID: 8116992.

View in: PubMed Mentions: 8 Fields:
Int Internal Medicine
Translation:Humans
Relations between factor VIIa binding and expression of factor VIIa/tissue factor catalytic activity on cell surfaces. J Biol Chem. 1992 Aug 05; 267(22):15447-54. Le DT, Rapaport SI, Rao LV. PMID: 1639786.

View in: PubMed Mentions: 40 Fields:
Bio Biochemistry
Translation:Humans Cells