Loading...

Antoni Duleba

TitleProfessor In Residence
InstitutionUniversity of California San Diego
DepartmentReproductive Medicine
Address9500 Gilman Drive #0633
La Jolla CA 92093
Phone858-534-8930
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Mevalonate pathway and thecal-interstitial function
    NIH/NICHD R01HD050656May 22, 2007 - Jun 30, 2013
    Role: Principal Investigator
    Role of Antioxidants in Ovarian Thecal Hyperplasiar
    NIH/NICHD R01HD040207Feb 1, 2002 - Mar 31, 2007
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Ciepiela P, Duleba AJ, Kowaleczko E, Chelstowski K, Kurzawa R. Vitamin D as a follicular marker of human oocyte quality and a serum marker of in vitro fertilization outcome. J Assist Reprod Genet. 2018 May 17. PMID: 29774457.
      View in: PubMed
    2. Hufnagel D, Goetz LG, Hu Z, Nyachieo A, D'Hooghe T, Fazleabas A, Duleba A, Krikun G, Taylor HS, Lockwood CJ. Icon immunoconjugate treatment results in regression of red lesions in a non-human primate (Papio anubis) model of endometriosis. Reprod Biol. 2018 Mar; 18(1):109-114. PMID: 29422377.
      View in: PubMed
    3. Torres PJ, Siakowska M, Banaszewska B, Pawelczyk L, Duleba AJ, Kelley ST, Thackray VG. Gut Microbial Diversity in Women with Polycystic Ovary Syndrome Correlates with Hyperandrogenism. J Clin Endocrinol Metab. 2018 Jan 23. PMID: 29370410.
      View in: PubMed
    4. Cosar E, Mamillapalli R, Moridi I, Duleba A, Taylor HS. Serum MicroRNA Biomarkers Regulated by Simvastatin in a Primate Model of Endometriosis. Reprod Sci. 2018 Jan 01; 1933719118765971. PMID: 29587611.
      View in: PubMed
    5. Taylor HS, Alderman Iii M, D'Hooghe TM, Fazleabas AT, Duleba AJ. Effect of simvastatin on baboon endometriosis. Biol Reprod. 2017 Jul 01; 97(1):32-38. PMID: 28637327.
      View in: PubMed
    6. Banaszewska B, Wrotynska-Barczynska J, Spaczynski RZ, Pawelczyk L, Duleba AJ. Effects of Resveratrol on Polycystic Ovary Syndrome: A Double-blind, Randomized, Placebo-controlled Trial. J Clin Endocrinol Metab. 2016 Nov; 101(11):4322-4328. PMID: 27754722.
      View in: PubMed
    7. Bruner-Tran KL, Duleba AJ, Taylor HS, Osteen KG. Developmental Toxicant Exposure Is Associated with Transgenerational Adenomyosis in a Murine Model. Biol Reprod. 2016 10 01; 95(4):73. PMID: 27535957.
      View in: PubMed
    8. Maas KH, Chuan S, Harrison E, Cook-Andersen H, Duleba AJ, Chang RJ. Androgen responses to adrenocorticotropic hormone infusion among individual women with polycystic ovary syndrome. Fertil Steril. 2016 Oct; 106(5):1252-1257. PMID: 27473350.
      View in: PubMed
    9. Ortega I, Duleba AJ. Ovarian actions of resveratrol. Ann N Y Acad Sci. 2015 Aug; 1348(1):86-96. PMID: 26315293.
      View in: PubMed
    10. Kauffman AS, Thackray VG, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba AJ, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon PL. A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice. Biol Reprod. 2015 Sep; 93(3):69. PMID: 26203175; PMCID: PMC4710190.
    11. Sokalska A, Stanley SD, Villanueva JA, Ortega I, Duleba AJ. Comparison of effects of different statins on growth and steroidogenesis of rat ovarian theca-interstitial cells. Biol Reprod. 2014 Feb; 90(2):44. PMID: 24389875; PMCID: PMC4076410.
    12. Ortega I, Villanueva JA, Wong DH, Cress AB, Sokalska A, Stanley SD, Duleba AJ. Resveratrol potentiates effects of simvastatin on inhibition of rat ovarian theca-interstitial cells steroidogenesis. J Ovarian Res. 2014 Feb 13; 7:21. PMID: 24524197; PMCID: PMC3940290.
    13. Benrick A, Maliqueo M, Miao S, Villanueva JA, Feng Y, Ohlsson C, Duleba AJ, Stener-Victorin E. Resveratrol is not as effective as physical exercise for improving reproductive and metabolic functions in rats with dihydrotestosterone-induced polycystic ovary syndrome. Evid Based Complement Alternat Med. 2013; 2013:964070. PMID: 23690868; PMCID: PMC3638597.
    14. Karakas SE, Banaszewska B, Spaczynski RZ, Pawelczyk L, Duleba A. Free fatty acid binding protein-4 and retinol binding protein-4 in polycystic ovary syndrome: response to simvastatin and metformin therapies. Gynecol Endocrinol. 2013 May; 29(5):483-7. PMID: 23480783.
      View in: PubMed
    15. Villanueva JA, Sokalska A, Cress AB, Ortega I, Bruner-Tran KL, Osteen KG, Duleba AJ. Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells. J Clin Endocrinol Metab. 2013 Mar; 98(3):E455-62. PMID: 23386644; PMCID: PMC3590465.
    16. Sokalska A, Anderson M, Villanueva J, Ortega I, Bruner-Tran KL, Osteen KG, Duleba AJ. Effects of simvastatin on retinoic acid system in primary human endometrial stromal cells and in a chimeric model of human endometriosis. J Clin Endocrinol Metab. 2013 Mar; 98(3):E463-71. PMID: 23337719; PMCID: PMC3590479.
    17. Ortega I, Sokalska A, Villanueva JA, Cress AB, Wong DH, Stener-Victorin E, Stanley SD, Duleba AJ. Letrozole increases ovarian growth and Cyp17a1 gene expression in the rat ovary. Fertil Steril. 2013 Mar 01; 99(3):889-96. PMID: 23200686; PMCID: PMC3667963.
    18. Maliqueo M, Sun M, Johansson J, Benrick A, Labrie F, Svensson H, Lönn M, Duleba AJ, Stener-Victorin E. Continuous administration of a P450 aromatase inhibitor induces polycystic ovary syndrome with a metabolic and endocrine phenotype in female rats at adult age. Endocrinology. 2013 Jan; 154(1):434-45. PMID: 23183180.
      View in: PubMed
    19. Ortega I, Wong DH, Villanueva JA, Cress AB, Sokalska A, Stanley SD, Duleba AJ. Effects of resveratrol on growth and function of rat ovarian granulosa cells. Fertil Steril. 2012 Dec; 98(6):1563-73. PMID: 22959450; PMCID: PMC3513511.
    20. Sokalska A, Cress A, Bruner-Tran KL, Osteen KG, Taylor HS, Ortega I, Duleba AJ. Simvastatin decreases invasiveness of human endometrial stromal cells. Biol Reprod. 2012 Jul; 87(1):2, 1-6. PMID: 22492974; PMCID: PMC3406552.
    21. Ortega I, Villanueva JA, Wong DH, Cress AB, Sokalska A, Stanley SD, Duleba AJ. Resveratrol reduces steroidogenesis in rat ovarian theca-interstitial cells: the role of inhibition of Akt/PKB signaling pathway. Endocrinology. 2012 Aug; 153(8):4019-29. PMID: 22719052; PMCID: PMC3404354.
    22. Witchel SF, Recabarren SE, González F, Diamanti-Kandarakis E, Cheang KI, Duleba AJ, Legro RS, Homburg R, Pasquali R, Lobo RA, Zouboulis CC, Kelestimur F, Fruzzetti F, Futterweit W, Norman RJ, Abbott DH. Emerging concepts about prenatal genesis, aberrant metabolism and treatment paradigms in polycystic ovary syndrome. Endocrine. 2012 Dec; 42(3):526-34. PMID: 22661293; PMCID: PMC3485440.
    23. Ortega I, Cress AB, Wong DH, Villanueva JA, Sokalska A, Moeller BC, Stanley SD, Duleba AJ. Simvastatin reduces steroidogenesis by inhibiting Cyp17a1 gene expression in rat ovarian theca-interstitial cells. Biol Reprod. 2012 Jan; 86(1):1-9. PMID: 21918126; PMCID: PMC3313666.
    24. Cakmak H, Basar M, Seval-Celik Y, Osteen KG, Duleba AJ, Taylor HS, Lockwood CJ, Arici A. Statins inhibit monocyte chemotactic protein 1 expression in endometriosis. Reprod Sci. 2012 Jun; 19(6):572-9. PMID: 22267540; PMCID: PMC3439122.
    25. Duleba AJ, Dokras A. Is PCOS an inflammatory process? Fertil Steril. 2012 Jan; 97(1):7-12. PMID: 22192135; PMCID: PMC3245829.
    26. Duleba AJ. Medical management of metabolic dysfunction in PCOS. Steroids. 2012 Mar 10; 77(4):306-11. PMID: 22182833; PMCID: PMC3409585.
    27. Wong DH, Villanueva JA, Cress AB, Sokalska A, Ortega I, Duleba AJ. Resveratrol inhibits the mevalonate pathway and potentiates the antiproliferative effects of simvastatin in rat theca-interstitial cells. Fertil Steril. 2011 Nov; 96(5):1252-8. PMID: 21907337.
      View in: PubMed
    28. Banaszewska B, Pawelczyk L, Spaczynski RZ, Duleba AJ. Effects of simvastatin and metformin on polycystic ovary syndrome after six months of treatment. J Clin Endocrinol Metab. 2011 Nov; 96(11):3493-501. PMID: 21865358; PMCID: PMC3205889.
    29. Taylor HS, Osteen KG, Bruner-Tran KL, Lockwood CJ, Krikun G, Sokalska A, Duleba AJ. Novel therapies targeting endometriosis. Reprod Sci. 2011 Sep; 18(9):814-23. PMID: 21693775; PMCID: PMC4046304.
    30. Pasquali R, Stener-Victorin E, Yildiz BO, Duleba AJ, Hoeger K, Mason H, Homburg R, Hickey T, Franks S, Tapanainen JS, Balen A, Abbott DH, Diamanti-Kandarakis E, Legro RS. PCOS Forum: research in polycystic ovary syndrome today and tomorrow. Clin Endocrinol (Oxf). 2011 Apr; 74(4):424-33. PMID: 21158892; PMCID: PMC3742326.
    31. Duleba AJ, Ahmed MI, Sun M, Gao AC, Villanueva J, Conley AJ, Turgeon JL, Benirschke K, Gee NA, Chen J, Green PG, Lasley BL. Effects of triclocarban on intact immature male rat: augmentation of androgen action. Reprod Sci. 2011 Feb; 18(2):119-27. PMID: 20889956; PMCID: PMC3031453.
    32. Morin-Papunen LC, Duleba AJ, Bloigu A, Järvelin MR, Saikku P, Pouta A. Chlamydia antibodies and self-reported symptoms of oligo-amenorrhea and hirsutism: a new etiologic factor in polycystic ovary syndrome? Fertil Steril. 2010 Oct; 94(5):1799-804. PMID: 19931073.
      View in: PubMed
    33. Bruner-Tran KL, Osteen KG, Taylor HS, Sokalska A, Haines K, Duleba AJ. Resveratrol inhibits development of experimental endometriosis in vivo and reduces endometrial stromal cell invasiveness in vitro. Biol Reprod. 2011 Jan; 84(1):106-12. PMID: 20844278; PMCID: PMC3012565.
    34. Rzepczynska IJ, Foyouzi N, Piotrowski PC, Celik-Ozenci C, Cress A, Duleba AJ. Antioxidants induce apoptosis of rat ovarian theca-interstitial cells. Biol Reprod. 2011 Jan; 84(1):162-6. PMID: 20844276; PMCID: PMC3012568.
    35. Sokalska A, Piotrowski PC, Rzepczynska IJ, Cress A, Duleba AJ. Statins inhibit growth of human theca-interstitial cells in PCOS and non-PCOS tissues independently of cholesterol availability. J Clin Endocrinol Metab. 2010 Dec; 95(12):5390-4. PMID: 20826585; PMCID: PMC2999973.
    36. Sokalska A, Wong DH, Cress A, Piotrowski PC, Rzepczynska I, Villanueva J, Duleba AJ. Simvastatin induces apoptosis and alters cytoskeleton in endometrial stromal cells. J Clin Endocrinol Metab. 2010 Jul; 95(7):3453-9. PMID: 20427495; PMCID: PMC2928904.
    37. Sokalska A, Duleba AJ, Pawelczyk LA. Correlation of the expression of integrin aVß3 in endometrium and peripheral blood lymphocytes in infertile patients. Reprod Sci. 2010 May; 17(5):487-93. PMID: 20224109.
      View in: PubMed
    38. Karakas SE, Kim K, Duleba AJ. Determinants of impaired fasting glucose versus glucose intolerance in polycystic ovary syndrome. Diabetes Care. 2010 Apr; 33(4):887-93. PMID: 20067969; PMCID: PMC2845047.
    39. Wong DH, Villanueva JA, Cress AB, Duleba AJ. Effects of resveratrol on proliferation and apoptosis in rat ovarian theca-interstitial cells. Mol Hum Reprod. 2010 Apr; 16(4):251-9. PMID: 20067985; PMCID: PMC2834407.
    40. Banaszewska B, Pawelczyk L, Spaczynski RZ, Duleba AJ. Comparison of simvastatin and metformin in treatment of polycystic ovary syndrome: prospective randomized trial. J Clin Endocrinol Metab. 2009 Dec; 94(12):4938-45. PMID: 19890022; PMCID: PMC2795658.
    41. Bruner-Tran KL, Carvalho-Macedo AC, Duleba AJ, Crispens MA, Osteen KG. Experimental endometriosis in immunocompromised mice after adoptive transfer of human leukocytes. Fertil Steril. 2010 May 15; 93(8):2519-24. PMID: 19608172; PMCID: PMC2873129.
    42. Rzepczynska IJ, Piotrowski PC, Wong DH, Cress AB, Villanueva J, Duleba AJ. Role of isoprenylation in simvastatin-induced inhibition of ovarian theca-interstitial growth in the rat. Biol Reprod. 2009 Nov; 81(5):850-5. PMID: 19571257; PMCID: PMC2770018.
    43. Bruner-Tran KL, Osteen KG, Duleba AJ. Simvastatin protects against the development of endometriosis in a nude mouse model. J Clin Endocrinol Metab. 2009 Jul; 94(7):2489-94. PMID: 19366846; PMCID: PMC2708947.
    44. Jedrzejczak P, Sokalska A, Spaczynski RZ, Duleba AJ, Pawelczyk L. Effects of presacral neurectomy on pelvic pain in women with and without endometriosis. Ginekol Pol. 2009 Mar; 80(3):172-8. PMID: 19382607.
      View in: PubMed
    45. Duleba AJ, Ahmed IM. Predictors of urinary albumin excretion in women with polycystic ovary syndrome. Fertil Steril. 2010 May 01; 93(7):2285-90. PMID: 19217093; PMCID: PMC2879627.
    46. Kodaman PH, Duleba AJ. Statins in the treatment of polycystic ovary syndrome. Semin Reprod Med. 2008 Jan; 26(1):127-38. PMID: 18181091; PMCID: PMC2854562.
    47. Kodaman PH, Duleba AJ. HMG-CoA reductase inhibitors: do they have potential in the treatment of polycystic ovary syndrome? Drugs. 2008; 68(13):1771-85. PMID: 18729532.
      View in: PubMed
    48. Chen J, Ahn KC, Gee NA, Ahmed MI, Duleba AJ, Zhao L, Gee SJ, Hammock BD, Lasley BL. Triclocarban enhances testosterone action: a new type of endocrine disruptor? Endocrinology. 2008 Mar; 149(3):1173-9. PMID: 18048496; PMCID: PMC2275366.
    49. Jedrzejczak P, Taszarek-Hauke G, Hauke J, Pawelczyk L, Duleba AJ. Prediction of spontaneous conception based on semen parameters. Int J Androl. 2008 Sep; 31(5):499-507. PMID: 17651398.
      View in: PubMed
    50. Salih S, Xu X, Veenstra TD, Duleba AJ, Fouad H, Nagamani M, Al-Hendy A. Lower levels of urinary 2-hydroxyestrogens in polycystic ovary syndrome. J Clin Endocrinol Metab. 2007 Aug; 92(8):3285-91. PMID: 17535988.
      View in: PubMed
    51. Diamanti-Kandarakis E, Piperi C, Patsouris E, Korkolopoulou P, Panidis D, Pawelczyk L, Papavassiliou AG, Duleba AJ. Immunohistochemical localization of advanced glycation end-products (AGEs) and their receptor (RAGE) in polycystic and normal ovaries. Histochem Cell Biol. 2007 Jun; 127(6):581-9. PMID: 17205306.
      View in: PubMed
    52. Banaszewska B, Pawelczyk L, Spaczynski RZ, Dziura J, Duleba AJ. Effects of simvastatin and oral contraceptive agent on polycystic ovary syndrome: prospective, randomized, crossover trial. J Clin Endocrinol Metab. 2007 Feb; 92(2):456-61. PMID: 17105841.
      View in: PubMed
    53. Kwintkiewicz J, Foyouzi N, Piotrowski P, Rzepczynska I, Duleba AJ. Mevastatin inhibits proliferation of rat ovarian theca-interstitial cells by blocking the mitogen-activated protein kinase pathway. Fertil Steril. 2006 Oct; 86(4 Suppl):1053-8. PMID: 16963032.
      View in: PubMed
    54. Banaszewska B, Duleba AJ, Spaczynski RZ, Pawelczyk L. Lipids in polycystic ovary syndrome: role of hyperinsulinemia and effects of metformin. Am J Obstet Gynecol. 2006 May; 194(5):1266-72. PMID: 16647909.
      View in: PubMed
    55. Piotrowski PC, Kwintkiewicz J, Rzepczynska IJ, Seval Y, Cakmak H, Arici A, Duleba AJ. Statins inhibit growth of human endometrial stromal cells independently of cholesterol availability. Biol Reprod. 2006 Jul; 75(1):107-11. PMID: 16571871.
      View in: PubMed
    56. Duleba AJ, Banaszewska B, Spaczynski RZ, Pawelczyk L. Simvastatin improves biochemical parameters in women with polycystic ovary syndrome: results of a prospective, randomized trial. Fertil Steril. 2006 Apr; 85(4):996-1001. PMID: 16580386.
      View in: PubMed
    57. Kwintkiewicz J, Spaczynski RZ, Foyouzi N, Pehlivan T, Duleba AJ. Insulin and oxidative stress modulate proliferation of rat ovarian theca-interstitial cells through diverse signal transduction pathways. Biol Reprod. 2006 Jun; 74(6):1034-40. PMID: 16481589.
      View in: PubMed
    58. Spaczynski RZ, Tilly JL, Mansour A, Duleba AJ. Insulin and insulin-like growth factors inhibit and luteinizing hormone augments ovarian theca-interstitial cell apoptosis. Mol Hum Reprod. 2005 May; 11(5):319-24. PMID: 15833775.
      View in: PubMed
    59. Izquierdo D, Foyouzi N, Kwintkiewicz J, Duleba AJ. Mevastatin inhibits ovarian theca-interstitial cell proliferation and steroidogenesis. Fertil Steril. 2004 Oct; 82 Suppl 3:1193-7. PMID: 15474095.
      View in: PubMed
    60. Foyouzi N, Berkkanoglu M, Arici A, Kwintkiewicz J, Izquierdo D, Duleba AJ. Effects of oxidants and antioxidants on proliferation of endometrial stromal cells. Fertil Steril. 2004 Oct; 82 Suppl 3:1019-22. PMID: 15474067.
      View in: PubMed
    61. Pawelczyk L, Spaczynski RZ, Banaszewska B, Duleba AJ. Metformin therapy increases insulin-like growth factor binding protein-1 in hyperinsulinemic women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2004 Apr 15; 113(2):209-13. PMID: 15063962.
      View in: PubMed
    62. Seli E, Duleba AJ. Treatment of PCOS with metformin and other insulin-sensitizing agents. Curr Diab Rep. 2004 Feb; 4(1):69-75. PMID: 14764283.
      View in: PubMed
    63. Spaczynski RZ, Duleba AJ. Diagnosis of endometriosis. Semin Reprod Med. 2003 May; 21(2):193-208. PMID: 12917789.
      View in: PubMed
    64. Duleba AJ, Banaszewska B, Spaczynski RZ, Pawelczyk L. Success of laparoscopic ovarian wedge resection is related to obesity, lipid profile, and insulin levels. Fertil Steril. 2003 Apr; 79(4):1008-14. PMID: 12749446.
      View in: PubMed
    65. Dokras A, Spaczynski RZ, Behrman HR, Duleba AJ. Testosterone levels in pregnant women correlate with the insulin response during the glucose tolerance test. Fertil Steril. 2003 Mar; 79(3):492-7. PMID: 12620428.
      View in: PubMed
    66. Townsend DE, Duleba AJ, Wilkes MM. Durability of treatment effects after endometrial cryoablation versus rollerball electroablation for abnormal uterine bleeding: two-year results of a multicenter randomized trial. Am J Obstet Gynecol. 2003 Mar; 188(3):699-701. PMID: 12634643.
      View in: PubMed
    67. Duleba AJ, Heppard MC, Soderstrom RM, Townsend DE. A randomized study comparing endometrial cryoablation and rollerball electroablation for treatment of dysfunctional uterine bleeding. J Am Assoc Gynecol Laparosc. 2003 Feb; 10(1):17-26. PMID: 12554989.
      View in: PubMed
    68. Seli E, Duleba AJ. Should patients with polycystic ovarian syndrome be treated with metformin? Hum Reprod. 2002 Sep; 17(9):2230-6. PMID: 12202407.
      View in: PubMed
    69. Mahutte NG, Arici A, Duleba A. Issues of bioequivalence and cost equivalence. Fertil Steril. 2002 Aug; 78(2):439-40; author reply 440. PMID: 12137897.
      View in: PubMed
    70. Seli E, Duleba AJ. Optimizing ovulation induction in women with polycystic ovary syndrome. Curr Opin Obstet Gynecol. 2002 Jun; 14(3):245-54. PMID: 12032379.
      View in: PubMed