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Antoni Duleba

TitleProfessor In Residence
InstitutionUniversity of California San Diego
DepartmentReproductive Medicine
Address9500 Gilman Drive #0633
La Jolla CA 92093
Phone858-534-8930
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    Collapse Research 
    Collapse Research Activities and Funding
    Mevalonate pathway and thecal-interstitial function
    NIH/NICHD R01HD050656May 22, 2007 - Jun 30, 2013
    Role: Principal Investigator
    Role of Antioxidants in Ovarian Thecal Hyperplasiar
    NIH/NICHD R01HD040207Feb 1, 2002 - Mar 31, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hufnagel D, Goetz LG, Hu Z, Nyachieo A, D'Hooghe T, Fazleabas A, Duleba A, Krikun G, Taylor HS, Lockwood CJ. Icon immunoconjugate treatment results in regression of red lesions in a non-human primate (Papio anubis) model of endometriosis. Reprod Biol. 2018 Mar; 18(1):109-114. PMID: 29422377.
      View in: PubMed
    2. Torres PJ, Siakowska M, Banaszewska B, Pawelczyk L, Duleba A, Kelley ST, Thackray VG. Gut Microbial Diversity in Women with Polycystic Ovary Syndrome Correlates with Hyperandrogenism. J Clin Endocrinol Metab. 2018 Jan 23. PMID: 29370410.
      View in: PubMed
    3. Cosar E, Mamillapalli R, Moridi I, Duleba A, Taylor HS. Serum MicroRNA Biomarkers Regulated by Simvastatin in a Primate Model of Endometriosis. Reprod Sci. 2018 Jan 01; 1933719118765971. PMID: 29587611.
      View in: PubMed
    4. Taylor HS, Alderman Iii M, D'Hooghe TM, Fazleabas AT, Duleba A. Effect of simvastatin on baboon endometriosis. Biol Reprod. 2017 Jul 01; 97(1):32-38. PMID: 28637327.
      View in: PubMed
    5. Banaszewska B, Wrotynska-Barczynska J, Spaczynski RZ, Pawelczyk L, Duleba A. Effects of Resveratrol on Polycystic Ovary Syndrome: A Double-blind, Randomized, Placebo-controlled Trial. J Clin Endocrinol Metab. 2016 Nov; 101(11):4322-4328. PMID: 27754722.
      View in: PubMed
    6. Bruner-Tran KL, Duleba A, Taylor HS, Osteen KG. Developmental Toxicant Exposure Is Associated with Transgenerational Adenomyosis in a Murine Model. Biol Reprod. 2016 10 01; 95(4):73. PMID: 27535957.
      View in: PubMed
    7. Ortega I, Duleba A. Ovarian actions of resveratrol. Ann N Y Acad Sci. 2015 Aug; 1348(1):86-96. PMID: 26315293.
      View in: PubMed
    8. Kauffman AS, Thackray VG, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba A, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon PL. A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice. Biol Reprod. 2015 Sep; 93(3):69. PMID: 26203175; PMCID: PMC4710190.
    9. Sokalska A, Stanley SD, Villanueva JA, Ortega I, Duleba A. Comparison of effects of different statins on growth and steroidogenesis of rat ovarian theca-interstitial cells. Biol Reprod. 2014 Feb; 90(2):44. PMID: 24389875; PMCID: PMC4076410.
    10. Ortega I, Villanueva JA, Wong DH, Cress AB, Sokalska A, Stanley SD, Duleba A. Resveratrol potentiates effects of simvastatin on inhibition of rat ovarian theca-interstitial cells steroidogenesis. J Ovarian Res. 2014 Feb 13; 7:21. PMID: 24524197; PMCID: PMC3940290.
    11. Benrick A, Maliqueo M, Miao S, Villanueva JA, Feng Y, Ohlsson C, Duleba A, Stener-Victorin E. Resveratrol is not as effective as physical exercise for improving reproductive and metabolic functions in rats with dihydrotestosterone-induced polycystic ovary syndrome. Evid Based Complement Alternat Med. 2013; 2013:964070. PMID: 23690868; PMCID: PMC3638597.
    12. Karakas SE, Banaszewska B, Spaczynski RZ, Pawelczyk L, Duleba A. Free fatty acid binding protein-4 and retinol binding protein-4 in polycystic ovary syndrome: response to simvastatin and metformin therapies. Gynecol Endocrinol. 2013 May; 29(5):483-7. PMID: 23480783.
      View in: PubMed
    13. Villanueva JA, Sokalska A, Cress AB, Ortega I, Bruner-Tran KL, Osteen KG, Duleba A. Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells. J Clin Endocrinol Metab. 2013 Mar; 98(3):E455-62. PMID: 23386644; PMCID: PMC3590465.
    14. Sokalska A, Anderson M, Villanueva J, Ortega I, Bruner-Tran KL, Osteen KG, Duleba A. Effects of simvastatin on retinoic acid system in primary human endometrial stromal cells and in a chimeric model of human endometriosis. J Clin Endocrinol Metab. 2013 Mar; 98(3):E463-71. PMID: 23337719; PMCID: PMC3590479.
    15. Ortega I, Sokalska A, Villanueva JA, Cress AB, Wong DH, Stener-Victorin E, Stanley SD, Duleba A. Letrozole increases ovarian growth and Cyp17a1 gene expression in the rat ovary. Fertil Steril. 2013 Mar 01; 99(3):889-96. PMID: 23200686; PMCID: PMC3667963.
    16. Maliqueo M, Sun M, Johansson J, Benrick A, Labrie F, Svensson H, Lönn M, Duleba A, Stener-Victorin E. Continuous administration of a P450 aromatase inhibitor induces polycystic ovary syndrome with a metabolic and endocrine phenotype in female rats at adult age. Endocrinology. 2013 Jan; 154(1):434-45. PMID: 23183180.
      View in: PubMed
    17. Ortega I, Wong DH, Villanueva JA, Cress AB, Sokalska A, Stanley SD, Duleba A. Effects of resveratrol on growth and function of rat ovarian granulosa cells. Fertil Steril. 2012 Dec; 98(6):1563-73. PMID: 22959450; PMCID: PMC3513511.
    18. Sokalska A, Cress A, Bruner-Tran KL, Osteen KG, Taylor HS, Ortega I, Duleba A. Simvastatin decreases invasiveness of human endometrial stromal cells. Biol Reprod. 2012 Jul; 87(1):2, 1-6. PMID: 22492974; PMCID: PMC3406552.
    19. Ortega I, Villanueva JA, Wong DH, Cress AB, Sokalska A, Stanley SD, Duleba A. Resveratrol reduces steroidogenesis in rat ovarian theca-interstitial cells: the role of inhibition of Akt/PKB signaling pathway. Endocrinology. 2012 Aug; 153(8):4019-29. PMID: 22719052; PMCID: PMC3404354.
    20. Witchel SF, Recabarren SE, González F, Diamanti-Kandarakis E, Cheang KI, Duleba A, Legro RS, Homburg R, Pasquali R, Lobo RA, Zouboulis CC, Kelestimur F, Fruzzetti F, Futterweit W, Norman RJ, Abbott DH. Emerging concepts about prenatal genesis, aberrant metabolism and treatment paradigms in polycystic ovary syndrome. Endocrine. 2012 Dec; 42(3):526-34. PMID: 22661293; PMCID: PMC3485440.
    21. Ortega I, Cress AB, Wong DH, Villanueva JA, Sokalska A, Moeller BC, Stanley SD, Duleba A. Simvastatin reduces steroidogenesis by inhibiting Cyp17a1 gene expression in rat ovarian theca-interstitial cells. Biol Reprod. 2012 Jan; 86(1):1-9. PMID: 21918126; PMCID: PMC3313666.
    22. Cakmak H, Basar M, Seval-Celik Y, Osteen KG, Duleba A, Taylor HS, Lockwood CJ, Arici A. Statins inhibit monocyte chemotactic protein 1 expression in endometriosis. Reprod Sci. 2012 Jun; 19(6):572-9. PMID: 22267540; PMCID: PMC3439122.
    23. Duleba A, Dokras A. Is PCOS an inflammatory process? Fertil Steril. 2012 Jan; 97(1):7-12. PMID: 22192135; PMCID: PMC3245829.
    24. Duleba A. Medical management of metabolic dysfunction in PCOS. Steroids. 2012 Mar 10; 77(4):306-11. PMID: 22182833; PMCID: PMC3409585.
    25. Wong DH, Villanueva JA, Cress AB, Sokalska A, Ortega I, Duleba A. Resveratrol inhibits the mevalonate pathway and potentiates the antiproliferative effects of simvastatin in rat theca-interstitial cells. Fertil Steril. 2011 Nov; 96(5):1252-8. PMID: 21907337.
      View in: PubMed
    26. Banaszewska B, Pawelczyk L, Spaczynski RZ, Duleba A. Effects of simvastatin and metformin on polycystic ovary syndrome after six months of treatment. J Clin Endocrinol Metab. 2011 Nov; 96(11):3493-501. PMID: 21865358; PMCID: PMC3205889.
    27. Taylor HS, Osteen KG, Bruner-Tran KL, Lockwood CJ, Krikun G, Sokalska A, Duleba A. Novel therapies targeting endometriosis. Reprod Sci. 2011 Sep; 18(9):814-23. PMID: 21693775; PMCID: PMC4046304.
    28. Pasquali R, Stener-Victorin E, Yildiz BO, Duleba A, Hoeger K, Mason H, Homburg R, Hickey T, Franks S, Tapanainen JS, Balen A, Abbott DH, Diamanti-Kandarakis E, Legro RS. PCOS Forum: research in polycystic ovary syndrome today and tomorrow. Clin Endocrinol (Oxf). 2011 Apr; 74(4):424-33. PMID: 21158892; PMCID: PMC3742326.
    29. Duleba A, Ahmed MI, Sun M, Gao AC, Villanueva J, Conley AJ, Turgeon JL, Benirschke K, Gee NA, Chen J, Green PG, Lasley BL. Effects of triclocarban on intact immature male rat: augmentation of androgen action. Reprod Sci. 2011 Feb; 18(2):119-27. PMID: 20889956; PMCID: PMC3031453.
    30. Morin-Papunen LC, Duleba A, Bloigu A, Järvelin MR, Saikku P, Pouta A. Chlamydia antibodies and self-reported symptoms of oligo-amenorrhea and hirsutism: a new etiologic factor in polycystic ovary syndrome? Fertil Steril. 2010 Oct; 94(5):1799-804. PMID: 19931073.
      View in: PubMed
    31. Bruner-Tran KL, Osteen KG, Taylor HS, Sokalska A, Haines K, Duleba A. Resveratrol inhibits development of experimental endometriosis in vivo and reduces endometrial stromal cell invasiveness in vitro. Biol Reprod. 2011 Jan; 84(1):106-12. PMID: 20844278; PMCID: PMC3012565.
    32. Rzepczynska IJ, Foyouzi N, Piotrowski PC, Celik-Ozenci C, Cress A, Duleba A. Antioxidants induce apoptosis of rat ovarian theca-interstitial cells. Biol Reprod. 2011 Jan; 84(1):162-6. PMID: 20844276; PMCID: PMC3012568.
    33. Sokalska A, Piotrowski PC, Rzepczynska IJ, Cress A, Duleba A. Statins inhibit growth of human theca-interstitial cells in PCOS and non-PCOS tissues independently of cholesterol availability. J Clin Endocrinol Metab. 2010 Dec; 95(12):5390-4. PMID: 20826585; PMCID: PMC2999973.
    34. Sokalska A, Wong DH, Cress A, Piotrowski PC, Rzepczynska I, Villanueva J, Duleba A. Simvastatin induces apoptosis and alters cytoskeleton in endometrial stromal cells. J Clin Endocrinol Metab. 2010 Jul; 95(7):3453-9. PMID: 20427495; PMCID: PMC2928904.
    35. Sokalska A, Duleba A, Pawelczyk LA. Correlation of the expression of integrin aVß3 in endometrium and peripheral blood lymphocytes in infertile patients. Reprod Sci. 2010 May; 17(5):487-93. PMID: 20224109.
      View in: PubMed
    36. Karakas SE, Kim K, Duleba A. Determinants of impaired fasting glucose versus glucose intolerance in polycystic ovary syndrome. Diabetes Care. 2010 Apr; 33(4):887-93. PMID: 20067969; PMCID: PMC2845047.
    37. Wong DH, Villanueva JA, Cress AB, Duleba A. Effects of resveratrol on proliferation and apoptosis in rat ovarian theca-interstitial cells. Mol Hum Reprod. 2010 Apr; 16(4):251-9. PMID: 20067985; PMCID: PMC2834407.
    38. Banaszewska B, Pawelczyk L, Spaczynski RZ, Duleba A. Comparison of simvastatin and metformin in treatment of polycystic ovary syndrome: prospective randomized trial. J Clin Endocrinol Metab. 2009 Dec; 94(12):4938-45. PMID: 19890022; PMCID: PMC2795658.
    39. Bruner-Tran KL, Carvalho-Macedo AC, Duleba A, Crispens MA, Osteen KG. Experimental endometriosis in immunocompromised mice after adoptive transfer of human leukocytes. Fertil Steril. 2010 May 15; 93(8):2519-24. PMID: 19608172; PMCID: PMC2873129.
    40. Rzepczynska IJ, Piotrowski PC, Wong DH, Cress AB, Villanueva J, Duleba A. Role of isoprenylation in simvastatin-induced inhibition of ovarian theca-interstitial growth in the rat. Biol Reprod. 2009 Nov; 81(5):850-5. PMID: 19571257; PMCID: PMC2770018.
    41. Bruner-Tran KL, Osteen KG, Duleba A. Simvastatin protects against the development of endometriosis in a nude mouse model. J Clin Endocrinol Metab. 2009 Jul; 94(7):2489-94. PMID: 19366846; PMCID: PMC2708947.
    42. Jedrzejczak P, Sokalska A, Spaczynski RZ, Duleba A, Pawelczyk L. Effects of presacral neurectomy on pelvic pain in women with and without endometriosis. Ginekol Pol. 2009 Mar; 80(3):172-8. PMID: 19382607.
      View in: PubMed
    43. Duleba A, Ahmed IM. Predictors of urinary albumin excretion in women with polycystic ovary syndrome. Fertil Steril. 2010 May 01; 93(7):2285-90. PMID: 19217093; PMCID: PMC2879627.
    44. Kodaman PH, Duleba A. Statins in the treatment of polycystic ovary syndrome. Semin Reprod Med. 2008 Jan; 26(1):127-38. PMID: 18181091; PMCID: PMC2854562.
    45. Kodaman PH, Duleba A. HMG-CoA reductase inhibitors: do they have potential in the treatment of polycystic ovary syndrome? Drugs. 2008; 68(13):1771-85. PMID: 18729532.
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    46. Chen J, Ahn KC, Gee NA, Ahmed MI, Duleba A, Zhao L, Gee SJ, Hammock BD, Lasley BL. Triclocarban enhances testosterone action: a new type of endocrine disruptor? Endocrinology. 2008 Mar; 149(3):1173-9. PMID: 18048496; PMCID: PMC2275366.
    47. Jedrzejczak P, Taszarek-Hauke G, Hauke J, Pawelczyk L, Duleba A. Prediction of spontaneous conception based on semen parameters. Int J Androl. 2008 Sep; 31(5):499-507. PMID: 17651398.
      View in: PubMed
    48. Salih S, Xu X, Veenstra TD, Duleba A, Fouad H, Nagamani M, Al-Hendy A. Lower levels of urinary 2-hydroxyestrogens in polycystic ovary syndrome. J Clin Endocrinol Metab. 2007 Aug; 92(8):3285-91. PMID: 17535988.
      View in: PubMed
    49. Diamanti-Kandarakis E, Piperi C, Patsouris E, Korkolopoulou P, Panidis D, Pawelczyk L, Papavassiliou AG, Duleba A. Immunohistochemical localization of advanced glycation end-products (AGEs) and their receptor (RAGE) in polycystic and normal ovaries. Histochem Cell Biol. 2007 Jun; 127(6):581-9. PMID: 17205306.
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    50. Banaszewska B, Pawelczyk L, Spaczynski RZ, Dziura J, Duleba A. Effects of simvastatin and oral contraceptive agent on polycystic ovary syndrome: prospective, randomized, crossover trial. J Clin Endocrinol Metab. 2007 Feb; 92(2):456-61. PMID: 17105841.
      View in: PubMed
    51. Kwintkiewicz J, Foyouzi N, Piotrowski P, Rzepczynska I, Duleba A. Mevastatin inhibits proliferation of rat ovarian theca-interstitial cells by blocking the mitogen-activated protein kinase pathway. Fertil Steril. 2006 Oct; 86(4 Suppl):1053-8. PMID: 16963032.
      View in: PubMed
    52. Banaszewska B, Duleba A, Spaczynski RZ, Pawelczyk L. Lipids in polycystic ovary syndrome: role of hyperinsulinemia and effects of metformin. Am J Obstet Gynecol. 2006 May; 194(5):1266-72. PMID: 16647909.
      View in: PubMed
    53. Piotrowski PC, Kwintkiewicz J, Rzepczynska IJ, Seval Y, Cakmak H, Arici A, Duleba A. Statins inhibit growth of human endometrial stromal cells independently of cholesterol availability. Biol Reprod. 2006 Jul; 75(1):107-11. PMID: 16571871.
      View in: PubMed
    54. Duleba A, Banaszewska B, Spaczynski RZ, Pawelczyk L. Simvastatin improves biochemical parameters in women with polycystic ovary syndrome: results of a prospective, randomized trial. Fertil Steril. 2006 Apr; 85(4):996-1001. PMID: 16580386.
      View in: PubMed
    55. Kwintkiewicz J, Spaczynski RZ, Foyouzi N, Pehlivan T, Duleba A. Insulin and oxidative stress modulate proliferation of rat ovarian theca-interstitial cells through diverse signal transduction pathways. Biol Reprod. 2006 Jun; 74(6):1034-40. PMID: 16481589.
      View in: PubMed
    56. Spaczynski RZ, Tilly JL, Mansour A, Duleba A. Insulin and insulin-like growth factors inhibit and luteinizing hormone augments ovarian theca-interstitial cell apoptosis. Mol Hum Reprod. 2005 May; 11(5):319-24. PMID: 15833775.
      View in: PubMed
    57. Izquierdo D, Foyouzi N, Kwintkiewicz J, Duleba A. Mevastatin inhibits ovarian theca-interstitial cell proliferation and steroidogenesis. Fertil Steril. 2004 Oct; 82 Suppl 3:1193-7. PMID: 15474095.
      View in: PubMed
    58. Foyouzi N, Berkkanoglu M, Arici A, Kwintkiewicz J, Izquierdo D, Duleba A. Effects of oxidants and antioxidants on proliferation of endometrial stromal cells. Fertil Steril. 2004 Oct; 82 Suppl 3:1019-22. PMID: 15474067.
      View in: PubMed
    59. Pawelczyk L, Spaczynski RZ, Banaszewska B, Duleba A. Metformin therapy increases insulin-like growth factor binding protein-1 in hyperinsulinemic women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2004 Apr 15; 113(2):209-13. PMID: 15063962.
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    60. Seli E, Duleba A. Treatment of PCOS with metformin and other insulin-sensitizing agents. Curr Diab Rep. 2004 Feb; 4(1):69-75. PMID: 14764283.
      View in: PubMed
    61. Spaczynski RZ, Duleba A. Diagnosis of endometriosis. Semin Reprod Med. 2003 May; 21(2):193-208. PMID: 12917789.
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    62. Duleba A, Banaszewska B, Spaczynski RZ, Pawelczyk L. Success of laparoscopic ovarian wedge resection is related to obesity, lipid profile, and insulin levels. Fertil Steril. 2003 Apr; 79(4):1008-14. PMID: 12749446.
      View in: PubMed
    63. Dokras A, Spaczynski RZ, Behrman HR, Duleba A. Testosterone levels in pregnant women correlate with the insulin response during the glucose tolerance test. Fertil Steril. 2003 Mar; 79(3):492-7. PMID: 12620428.
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    64. Townsend DE, Duleba A, Wilkes MM. Durability of treatment effects after endometrial cryoablation versus rollerball electroablation for abnormal uterine bleeding: two-year results of a multicenter randomized trial. Am J Obstet Gynecol. 2003 Mar; 188(3):699-701. PMID: 12634643.
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    65. Duleba A, Heppard MC, Soderstrom RM, Townsend DE. A randomized study comparing endometrial cryoablation and rollerball electroablation for treatment of dysfunctional uterine bleeding. J Am Assoc Gynecol Laparosc. 2003 Feb; 10(1):17-26. PMID: 12554989.
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    66. Seli E, Duleba A. Should patients with polycystic ovarian syndrome be treated with metformin? Hum Reprod. 2002 Sep; 17(9):2230-6. PMID: 12202407.
      View in: PubMed
    67. Mahutte NG, Arici A, Duleba A. Issues of bioequivalence and cost equivalence. Fertil Steril. 2002 Aug; 78(2):439-40; author reply 440. PMID: 12137897.
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    68. Seli E, Duleba A. Optimizing ovulation induction in women with polycystic ovary syndrome. Curr Opin Obstet Gynecol. 2002 Jun; 14(3):245-54. PMID: 12032379.
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