Don Cleveland

Title(s)Professor, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Overview 
    Collapse Overview
    Cleveland is interested in the genes and proteins involved in mitotic spindle assembly and faithful chromosome segregation just prior to division. This process is particularly relevant to the development of cancer because it is thought that cancer cells mis-segregate chromosomes due to errors in mitosis resulting in aneuploidy. The major pathway guarding against whole chromosome mis-segregation is the mitotic checkpoint, a cell cycle control mechanism in which the centromeres of unattached chromosomes generate an inhibitor that blocks cyclin B degradation and advance across mitosis. The antitumor drug taxol is effective by chronically activating this checkpoint. In the past year, starting from all purified components Cleveland’s efforts have reconstructed mitotic checkpoint signaling in vitro. Additionally, abnormalities in number of microtubule organizing centers (centrosomes) can promote errors in spindle formation that lead to subsequent chromosome missegregation and extra centrosomes are associated with many cancers. Like DNA, centrosomes are duplicated only once each cell cycle. The duplication process is governed by polo-like kinase 4 (Plk4). Cleveland’s recent efforts identified how centrosome over-replication is blocked: kinase-mediated, autoregulated instability of Plk4 acts to self-limit Plk4 activity so as to prevent centrosome amplification.

    Clinical Interests
    - Cancer Biology
    - Amyotrophic lateral sclerosis

    Collapse Research 
    Collapse Research Activities and Funding
    TDP-43 acetylation, phase separation, aggregation, and clearance by antibody-mediated degradation
    NIH R01NS121604Apr 1, 2021 - Mar 31, 2026
    Role: Principal Investigator
    Determining stathmin-2 function and potential as a therapeutic target in ALS/FTD
    NIH R01NS112503Apr 1, 2020 - Mar 31, 2025
    Role: Principal Investigator
    Mechanisms of chromosome segregation, aneuploidy, and tumorigenesis
    NIH R35GM122476May 1, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Junior Faculty and Postdoctoral Fellows Career Development Workshop
    NIH R13GM111037Sep 15, 2014 - Aug 31, 2016
    Role: Principal Investigator
    ALS therapies and genomics for mutant TDP-43 and TLS/FUS
    NIH RC1NS069144Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Delivery of therapeutic genes in motor neuron disease
    NIH RC2NS069476Sep 30, 2009 - Aug 31, 2012
    Role: Co-Principal Investigator
    Mammalian Centromere Assembly
    NIH R01GM074150Feb 1, 2006 - Aug 31, 2018
    Role: Principal Investigator
    6TH INTERNATIONAL CONGRESS ON CELL BIOLOGY
    NIH R13CA072388Sep 30, 1996 - Sep 29, 1997
    Role: Principal Investigator
    Disease mechanism in ALS and frontotemporal dementia
    NIH R01NS027036Apr 1, 1989 - Aug 31, 2022
    Role: Principal Investigator
    Neurofilaments, SOD1 and Motor Neuron Diseases
    NIH R37NS027036Apr 1, 1989 - May 31, 2012
    Role: Principal Investigator
    MICROTUBULE REGULATION: CONTROL OF EXPRESSION OF TUBULI
    NIH K04HD000504Sep 30, 1982 - Aug 31, 1987
    Role: Principal Investigator
    Guarding the Genome: Aneuploidy and tumorigenesis
    NIH R01GM029513Jul 1, 1981 - Aug 31, 2017
    Role: Principal Investigator
    MICROTUBULE REGULATION
    NIH R37GM029513Jul 1, 1981 - Jun 30, 2004
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Transient genomic instability drives tumorigenesis through accelerated clonal evolution. Genes Dev. 2021 Jul 15. Shoshani O, Bakker B, de Haan L, Tijhuis AE, Wang Y, Kim DH, Maldonado M, Demarest MA, Artates J, Zhengyu O, Mark A, Wardenaar R, Sasik R, Spierings DCJ, Vitre B, Fisch K, Foijer F, Cleveland DW. PMID: 34266887.
      View in: PubMed   Mentions:    Fields:    
    2. Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB. Nat Neurosci. 2021 Jun 03. Maimon R, Chillon-Marinas C, Snethlage CE, Singhal SM, McAlonis-Downes M, Ling K, Rigo F, Bennett CF, Da Cruz S, Hnasko TS, Muotri AR, Cleveland DW. PMID: 34083786.
      View in: PubMed   Mentions:    Fields:    
    3. Immune evasion in HPV- head and neck precancer-cancer transition is driven by an aneuploid switch involving chromosome 9p loss. Proc Natl Acad Sci U S A. 2021 May 11; 118(19). William WN, Zhao X, Bianchi JJ, Lin HY, Cheng P, Lee JJ, Carter H, Alexandrov LB, Abraham JP, Spetzler DB, Dubinett SM, Cleveland DW, Cavenee W, Davoli T, Lippman SM. PMID: 33952700.
      View in: PubMed   Mentions:    Fields:    
    4. Novel STMN2 Variant Linked to Amyotrophic Lateral Sclerosis Risk and Clinical Phenotype. Front Aging Neurosci. 2021; 13:658226. Theunissen F, Anderton RS, Mastaglia FL, Flynn LL, Winter SJ, James I, Bedlack R, Hodgetts S, Fletcher S, Wilton SD, Laing NG, MacShane M, Needham M, Saunders A, Mackay-Sim A, Melamed Z, Ravits J, Cleveland DW, Akkari PA. PMID: 33841129.
      View in: PubMed   Mentions:
    5. Publisher Correction: Chromothripsis drives the evolution of gene amplification in cancer. Nature. 2021 Mar; 591(7850):E19. Shoshani O, Brunner SF, Yaeger R, Ly P, Nechemia-Arbely Y, Kim DH, Fang R, Castillon GA, Yu M, Li JSZ, Sun Y, Ellisman MH, Ren B, Campbell PJ, Cleveland DW. PMID: 33649505.
      View in: PubMed   Mentions:    Fields:    
    6. Causes and consequences of micronuclei. Curr Opin Cell Biol. 2021 Jun; 70:91-99. Krupina K, Goginashvili A, Cleveland DW. PMID: 33610905.
      View in: PubMed   Mentions: 1     Fields:    
    7. The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein. Nat Commun. 2021 01 21; 12(1):502. Lu S, Ye Q, Singh D, Cao Y, Diedrich JK, Yates JR, Villa E, Cleveland DW, Corbett KD. PMID: 33479198.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    8. Chromothripsis drives the evolution of gene amplification in cancer. Nature. 2021 03; 591(7848):137-141. Shoshani O, Brunner SF, Yaeger R, Ly P, Nechemia-Arbely Y, Kim DH, Fang R, Castillon GA, Yu M, Li JSZ, Sun Y, Ellisman MH, Ren B, Campbell PJ, Cleveland DW. PMID: 33361815.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    9. HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells. Science. 2021 02 05; 371(6529). Yu H, Lu S, Gasior K, Singh D, Vazquez-Sanchez S, Tapia O, Toprani D, Beccari MS, Yates JR, Da Cruz S, Newby JM, Lafarga M, Gladfelter AS, Villa E, Cleveland DW. PMID: 33335017.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    10. Antisense Drugs Make Sense for Neurological Diseases. Annu Rev Pharmacol Toxicol. 2021 01 06; 61:831-852. Bennett CF, Kordasiewicz HB, Cleveland DW. PMID: 33035446.
      View in: PubMed   Mentions: 2     Fields:    
    11. Author Correction: Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature. 2020 Aug; 584(7820):E17. Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD. PMID: 32724206.
      View in: PubMed   Mentions:    Fields:    
    12. The SARS-CoV-2 Nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein. bioRxiv. 2020 Jul 31. Lu S, Ye Q, Singh D, Villa E, Cleveland DW, Corbett KD. PMID: 32766587.
      View in: PubMed   Mentions:
    13. Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature. 2020 06; 582(7813):550-556. Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD. PMID: 32581380.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    14. ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS. Neuron. 2020 04 22; 106(2):354. López-Erauskin J, Tadokoro T, Baughn MW, Myers B, McAlonis-Downes M, Chillon-Marinas C, Asiaban JN, Artates J, Bui AT, Vetto AP, Lee SK, Le AV, Sun Y, Jambeau M, Boubaker J, Swing D, Qiu J, Hicks GG, Ouyang Z, Fu XD, Tessarollo L, Ling SC, Parone PA, Shaw CE, Marsala M, Lagier-Tourenne C, Cleveland DW, Da Cruz S. PMID: 32325059.
      View in: PubMed   Mentions: 2     Fields:    
    15. Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72. Nat Neurosci. 2020 05; 23(5):615-624. Zhu Q, Jiang J, Gendron TF, McAlonis-Downes M, Jiang L, Taylor A, Diaz Garcia S, Ghosh Dastidar S, Rodriguez MJ, King P, Zhang Y, La Spada AR, Xu H, Petrucelli L, Ravits J, Da Cruz S, Lagier-Tourenne C, Cleveland DW. PMID: 32284607.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    16. Gene expression regulated by RNA stability. Science. 2020 01 03; 367(6473):29. Shoshani O, Cleveland DW. PMID: 31896707.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    17. Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS. Nat Med. 2020 01; 26(1):118-130. Bravo-Hernandez M, Tadokoro T, Navarro MR, Platoshyn O, Kobayashi Y, Marsala S, Miyanohara A, Juhas S, Juhasova J, Skalnikova H, Tomori Z, Vanicky I, Studenovska H, Proks V, Chen P, Govea-Perez N, Ditsworth D, Ciacci JD, Gao S, Zhu W, Ahrens ET, Driscoll SP, Glenn TD, McAlonis-Downes M, Da Cruz S, Pfaff SL, Kaspar BK, Cleveland DW, Marsala M. PMID: 31873312.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    18. CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation. Neuron. 2019 12 04; 104(5):885-898.e8. Cheng W, Wang S, Zhang Z, Morgens DW, Hayes LR, Lee S, Portz B, Xie Y, Nguyen BV, Haney MS, Yan S, Dong D, Coyne AN, Yang J, Xian F, Cleveland DW, Qiu Z, Rothstein JD, Shorter J, Gao FB, Bassik MC, Sun S. PMID: 31587919.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    19. Antisense Oligonucleotide Therapies for Neurodegenerative Diseases. Annu Rev Neurosci. 2019 07 08; 42:385-406. Bennett CF, Krainer AR, Cleveland DW. PMID: 31283897.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    20. BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules. Cell Res. 2019 07; 29(7):562-578. Huang Y, Lin L, Liu X, Ye S, Yao PY, Wang W, Yang F, Gao X, Li J, Zhang Y, Zhang J, Yang Z, Liu X, Yang Z, Zang J, Teng M, Wang Z, Ruan K, Ding X, Li L, Cleveland DW, Zhang R, Yao X. PMID: 31201382.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    21. DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres. Nat Cell Biol. 2019 06; 21(6):743-754. Nechemia-Arbely Y, Miga KH, Shoshani O, Aslanian A, McMahon MA, Lee AY, Fachinetti D, Yates JR, Ren B, Cleveland DW. PMID: 31160708.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    22. Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment. J Clin Invest. 2019 05 21; 129(8):3103-3120. Jiang LL, Zhu B, Zhao Y, Li X, Liu T, Pina-Crespo J, Zhou L, Xu W, Rodriguez MJ, Yu H, Cleveland DW, Ravits J, Da Cruz S, Long T, Zhang D, Huang TY, Xu H. PMID: 31112137.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    23. Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death. Neuron. 2019 04 17; 102(2):339-357.e7. Gasset-Rosa F, Lu S, Yu H, Chen C, Melamed Z, Guo L, Shorter J, Da Cruz S, Cleveland DW. PMID: 30853299.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    24. Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements. Nat Genet. 2019 04; 51(4):705-715. Ly P, Brunner SF, Shoshani O, Kim DH, Lan W, Pyntikova T, Flanagan AM, Behjati S, Page DC, Campbell PJ, Cleveland DW. PMID: 30833795.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    25. Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis. Elife. 2019 02 12; 8. Ling SC, Dastidar SG, Tokunaga S, Ho WY, Lim K, Ilieva H, Parone PA, Tyan SH, Tse TM, Chang JC, Platoshyn O, Bui NB, Bui A, Vetto A, Sun S, McAlonis-Downes M, Han JS, Swing D, Kapeli K, Yeo GW, Tessarollo L, Marsala M, Shaw CE, Tucker-Kellogg G, La Spada AR, Lagier-Tourenne C, Da Cruz S, Cleveland DW. PMID: 30747709.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    26. Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration. Nat Neurosci. 2019 02; 22(2):180-190. Melamed Z, López-Erauskin J, Baughn MW, Zhang O, Drenner K, Sun Y, Freyermuth F, McMahon MA, Beccari MS, Artates JW, Ohkubo T, Rodriguez M, Lin N, Wu D, Bennett CF, Rigo F, Da Cruz S, Ravits J, Lagier-Tourenne C, Cleveland DW. PMID: 30643298.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    27. Phosphorylation of CENP-A on serine 7 does not control centromere function. Nat Commun. 2019 01 11; 10(1):175. Barra V, Logsdon GA, Scelfo A, Hoffmann S, Hervé S, Aslanian A, Nechemia-Arbely Y, Cleveland DW, Black BE, Fachinetti D. PMID: 30635586.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    28. TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC. Nat Commun. 2018 10 19; 9(1):4354. Kim DH, Han JS, Ly P, Ye Q, McMahon MA, Myung K, Corbett KD, Cleveland DW. PMID: 30341343.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    29. ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS. Neuron. 2018 11 21; 100(4):816-830.e7. López-Erauskin J, Tadokoro T, Baughn MW, Myers B, McAlonis-Downes M, Chillon-Marinas C, Asiaban JN, Artates J, Bui AT, Vetto AP, Lee SK, Le AV, Sun Y, Jambeau M, Boubaker J, Swing D, Qiu J, Hicks GG, Ouyang Z, Fu XD, Tessarollo L, Ling SC, Parone PA, Shaw CE, Marsala M, Lagier-Tourenne C, Cleveland DW, Da Cruz S. PMID: 30344044.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    30. Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1. Cell. 2018 09 06; 174(6):1339-1341. Yu H, Cleveland DW. PMID: 30193106.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    31. Probing Mitotic CENP-E Kinesin with the Tethered Cargo Motion Assay and Laser Tweezers. Biophys J. 2018 06 05; 114(11):2640-2652. Gudimchuk N, Tarasovetc EV, Mustyatsa V, Drobyshev AL, Vitre B, Cleveland DW, Ataullakhanov FI, Grishchuk EL. PMID: 29874614.
      View in: PubMed   Mentions: 3     Fields:    
    32. Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients. Acta Neuropathol. 2018 09; 136(3):425-443. Bennett CL, Dastidar SG, Ling SC, Malik B, Ashe T, Wadhwa M, Miller DB, Lee C, Mitchell MB, van Es MA, Grunseich C, Chen Y, Sopher BL, Greensmith L, Cleveland DW, La Spada AR. PMID: 29725819.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    33. Chemically Modified Cpf1-CRISPR RNAs Mediate Efficient Genome Editing in Mammalian Cells. Mol Ther. 2018 05 02; 26(5):1228-1240. McMahon MA, Prakash TP, Cleveland DW, Bennett CF, Rahdar M. PMID: 29650467.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    34. Chromosomal instability drives metastasis through a cytosolic DNA response. Nature. 2018 01 25; 553(7689):467-472. Bakhoum SF, Ngo B, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, Genovese G, Venkatesan S, Birkbak NJ, McGranahan N, Lundquist M, LaPlant Q, Healey JH, Elemento O, Chung CH, Lee NY, Imielenski M, Nanjangud G, Pe'er D, Cleveland DW, Powell SN, Lammerding J, Swanton C, Cantley LC. PMID: 29342134.
      View in: PubMed   Mentions: 252     Fields:    Translation:HumansAnimalsCells
    35. C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2a phosphorylation. Nat Commun. 2018 01 04; 9(1):51. Cheng W, Wang S, Mestre AA, Fu C, Makarem A, Xian F, Hayes LR, Lopez-Gonzalez R, Drenner K, Jiang J, Cleveland DW, Sun S. PMID: 29302060.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    36. Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis. Acta Neuropathol. 2018 03; 135(3):459-474. Saberi S, Stauffer JE, Jiang J, Garcia SD, Taylor AE, Schulte D, Ohkubo T, Schloffman CL, Maldonado M, Baughn M, Rodriguez MJ, Pizzo D, Cleveland D, Ravits J. PMID: 29196813.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    37. Rethinking Unconventional Translation in Neurodegeneration. Cell. 2017 Nov 16; 171(5):994-1000. Gao FB, Richter JD, Cleveland DW. PMID: 29149615.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    38. Biological Spectrum of Amyotrophic Lateral Sclerosis Prions. Cold Spring Harb Perspect Med. 2017 Nov 01; 7(11). Polymenidou M, Cleveland DW. PMID: 28062558.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    39. Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis. Trends Cell Biol. 2017 12; 27(12):917-930. Ly P, Cleveland DW. PMID: 28899600.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    40. The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding. EMBO J. 2017 08 15; 36(16):2419-2434. Ye Q, Kim DH, Dereli I, Rosenberg SC, Hagemann G, Herzog F, Tóth A, Cleveland DW, Corbett KD. PMID: 28659378.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    41. Interrogating cell division errors using random and chromosome-specific missegregation approaches. . 2017 Jul 03; 16(13):1252-1258. Ly P, Cleveland DW. PMID: 28650219.
      View in: PubMed   Mentions:
    42. Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition. Nat Commun. 2017 06 09; 8:15775. Guo LY, Allu PK, Zandarashvili L, McKinley KL, Sekulic N, Dawicki-McKenna JM, Fachinetti D, Logsdon GA, Jamiolkowski RM, Cleveland DW, Cheeseman IM, Black BE. PMID: 28598437.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    43. Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport. Neuron. 2017 Apr 05; 94(1):48-57.e4. Gasset-Rosa F, Chillon-Marinas C, Goginashvili A, Atwal RS, Artates JW, Tabet R, Wheeler VC, Bang AG, Cleveland DW, Lagier-Tourenne C. PMID: 28384474.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    44. Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis. Acta Neuropathol. 2017 06; 133(6):907-922. Ditsworth D, Maldonado M, McAlonis-Downes M, Sun S, Seelman A, Drenner K, Arnold E, Ling SC, Pizzo D, Ravits J, Cleveland DW, Da Cruz S. PMID: 28357566.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    45. Misfolded SOD1 is not a primary component of sporadic ALS. Acta Neuropathol. 2017 07; 134(1):97-111. Da Cruz S, Bui A, Saberi S, Lee SK, Stauffer J, McAlonis-Downes M, Schulte D, Pizzo DP, Parone PA, Cleveland DW, Ravits J. PMID: 28247063.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    46. Human centromeric CENP-A chromatin is a homotypic, octameric nucleosome at all cell cycle points. J Cell Biol. 2017 03 06; 216(3):607-621. Nechemia-Arbely Y, Fachinetti D, Miga KH, Sekulic N, Soni GV, Kim DH, Wong AK, Lee AY, Nguyen K, Dekker C, Ren B, Black BE, Cleveland DW. PMID: 28235947.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    47. Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals. Dev Cell. 2017 02 06; 40(3):313-322.e5. Levine MS, Bakker B, Boeckx B, Moyett J, Lu J, Vitre B, Spierings DC, Lansdorp PM, Cleveland DW, Lambrechts D, Foijer F, Holland AJ. PMID: 28132847.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    48. CENP-A Modifications on Ser68 and Lys124 Are Dispensable for Establishment, Maintenance, and Long-Term Function of Human Centromeres. Dev Cell. 2017 01 09; 40(1):104-113. Fachinetti D, Logsdon GA, Abdullah A, Selzer EB, Cleveland DW, Black BE. PMID: 28073008.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    49. Bidirectional Transcriptional Inhibition as Therapy for ALS/FTD Caused by Repeat Expansion in C9orf72. Neuron. 2016 Dec 21; 92(6):1160-1163. Jiang J, Cleveland DW. PMID: 28009271.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    50. Gene therapy: Gene-editing therapy for neurological disease. Nat Rev Neurol. 2017 01; 13(1):7-9. McMahon MA, Cleveland DW. PMID: 27982043.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    51. Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining. Nat Cell Biol. 2017 Jan; 19(1):68-75. Ly P, Teitz LS, Kim DH, Shoshani O, Skaletsky H, Fachinetti D, Page DC, Cleveland DW. PMID: 27918550.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    52. CENP-A Is Dispensable for Mitotic Centromere Function after Initial Centromere/Kinetochore Assembly. Cell Rep. 2016 11 22; 17(9):2394-2404. Hoffmann S, Dumont M, Barra V, Ly P, Nechemia-Arbely Y, McMahon MA, Hervé S, Cleveland DW, Fachinetti D. PMID: 27880912.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    53. Decoding ALS: from genes to mechanism. Nature. 2016 Nov 10; 539(7628):197-206. Taylor JP, Brown RH, Cleveland DW. PMID: 27830784.
      View in: PubMed   Mentions: 510     Fields:    Translation:HumansAnimalsCells
    54. Potent spinal parenchymal AAV9-mediated gene delivery by subpial injection in adult rats and pigs. Mol Ther Methods Clin Dev. 2016; 3:16046. Miyanohara A, Kamizato K, Juhas S, Juhasova J, Navarro M, Marsala S, Lukacova N, Hruska-Plochan M, Curtis E, Gabel B, Ciacci J, Ahrens ET, Kaspar BK, Cleveland D, Marsala M. PMID: 27462649.
      View in: PubMed   Mentions:
    55. Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis. Free Radic Biol Med. 2016 08; 97:95-108. Seredenina T, Nayernia Z, Sorce S, Maghzal GJ, Filippova A, Ling SC, Basset O, Plastre O, Daali Y, Rushing EJ, Giordana MT, Cleveland DW, Aguzzi A, Stocker R, Krause KH, Jaquet V. PMID: 27212019.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
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