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Don Cleveland

Title(s)Professor, Cellular and Molecular Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0660
La Jolla CA 92093
Phone858-534-7811
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    Collapse Overview 
    Collapse Overview
    Cleveland is interested in the genes and proteins involved in mitotic spindle assembly and faithful chromosome segregation just prior to division. This process is particularly relevant to the development of cancer because it is thought that cancer cells mis-segregate chromosomes due to errors in mitosis resulting in aneuploidy. The major pathway guarding against whole chromosome mis-segregation is the mitotic checkpoint, a cell cycle control mechanism in which the centromeres of unattached chromosomes generate an inhibitor that blocks cyclin B degradation and advance across mitosis. The antitumor drug taxol is effective by chronically activating this checkpoint. In the past year, starting from all purified components Cleveland’s efforts have reconstructed mitotic checkpoint signaling in vitro. Additionally, abnormalities in number of microtubule organizing centers (centrosomes) can promote errors in spindle formation that lead to subsequent chromosome missegregation and extra centrosomes are associated with many cancers. Like DNA, centrosomes are duplicated only once each cell cycle. The duplication process is governed by polo-like kinase 4 (Plk4). Cleveland’s recent efforts identified how centrosome over-replication is blocked: kinase-mediated, autoregulated instability of Plk4 acts to self-limit Plk4 activity so as to prevent centrosome amplification.

    Clinical Interests
    - Cancer Biology
    - Amyotrophic lateral sclerosis

    Collapse Research 
    Collapse Research Activities and Funding
    Determining stathmin-2 function and potential as a therapeutic target in ALS/FTD
    NIH/NINDS R01NS112503Apr 1, 2020 - Mar 31, 2025
    Role: Principal Investigator
    Mechanisms of chromosome segregation, aneuploidy, and tumorigenesis
    NIH/NIGMS R35GM122476May 1, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Junior Faculty and Postdoctoral Fellows Career Development Workshop
    NIH/NIGMS R13GM111037Sep 15, 2014 - Aug 31, 2015
    Role: Principal Investigator
    ALS therapies and genomics for mutant TDP-43 and TLS/FUS
    NIH/NINDS RC1NS069144Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Delivery of therapeutic genes in motor neuron disease
    NIH/NINDS RC2NS069476Sep 30, 2009 - Aug 31, 2012
    Role: Co-Principal Investigator
    Mammalian Centromere Assembly
    NIH/NIGMS R01GM074150Feb 1, 2006 - Jan 31, 2015
    Role: Principal Investigator
    6TH INTERNATIONAL CONGRESS ON CELL BIOLOGY
    NIH/NCI R13CA072388Sep 30, 1996 - Sep 29, 1997
    Role: Principal Investigator
    Disease mechanism in ALS and frontotemporal dementia
    NIH/NINDS R01NS027036Apr 1, 1989 - May 31, 2017
    Role: Principal Investigator
    Neurofilaments, SOD1 and Motor Neuron Diseases
    NIH/NINDS R37NS027036Apr 1, 1989 - May 31, 2012
    Role: Principal Investigator
    MICROTUBULE REGULATION: CONTROL OF EXPRESSION OF TUBULI
    NIH/NICHD K04HD000504Sep 30, 1982 - Aug 31, 1987
    Role: Principal Investigator
    Guarding the Genome: Aneuploidy and tumorigenesis
    NIH/NIGMS R01GM029513Jul 1, 1981 - May 31, 2016
    Role: Principal Investigator
    MICROTUBULE REGULATION
    NIH/NIGMS R37GM029513Jul 1, 1981 - Jun 30, 2004
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS. Neuron. 2020 Apr 22; 106(2):354. López-Erauskin J, Tadokoro T, Baughn MW, Myers B, McAlonis-Downes M, Chillon-Marinas C, Asiaban JN, Artates J, Bui AT, Vetto AP, Lee SK, Le AV, Sun Y, Jambeau M, Boubaker J, Swing D, Qiu J, Hicks GG, Ouyang Z, Fu XD, Tessarollo L, Ling SC, Parone PA, Shaw CE, Marsala M, Lagier-Tourenne C, Cleveland DW, Da Cruz S. PMID: 32325059.
      View in: PubMed   Mentions:    Fields:    
    2. Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72. Nat Neurosci. 2020 May; 23(5):615-624. Zhu Q, Jiang J, Gendron TF, McAlonis-Downes M, Jiang L, Taylor A, Diaz Garcia S, Ghosh Dastidar S, Rodriguez MJ, King P, Zhang Y, La Spada AR, Xu H, Petrucelli L, Ravits J, Da Cruz S, Lagier-Tourenne C, Cleveland DW. PMID: 32284607.
      View in: PubMed   Mentions: 2     Fields:    
    3. Gene expression regulated by RNA stability. Science. 2020 01 03; 367(6473):29. Shoshani O, Cleveland DW. PMID: 31896707.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    4. Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS. Nat Med. 2020 01; 26(1):118-130. Bravo-Hernandez M, Tadokoro T, Navarro MR, Platoshyn O, Kobayashi Y, Marsala S, Miyanohara A, Juhas S, Juhasova J, Skalnikova H, Tomori Z, Vanicky I, Studenovska H, Proks V, Chen P, Govea-Perez N, Ditsworth D, Ciacci JD, Gao S, Zhu W, Ahrens ET, Driscoll SP, Glenn TD, McAlonis-Downes M, Da Cruz S, Pfaff SL, Kaspar BK, Cleveland DW, Marsala M. PMID: 31873312.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation. Neuron. 2019 12 04; 104(5):885-898.e8. Cheng W, Wang S, Zhang Z, Morgens DW, Hayes LR, Lee S, Portz B, Xie Y, Nguyen BV, Haney MS, Yan S, Dong D, Coyne AN, Yang J, Xian F, Cleveland DW, Qiu Z, Rothstein JD, Shorter J, Gao FB, Bassik MC, Sun S. PMID: 31587919.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    6. Antisense Oligonucleotide Therapies for Neurodegenerative Diseases. Annu Rev Neurosci. 2019 07 08; 42:385-406. Bennett CF, Krainer AR, Cleveland DW. PMID: 31283897.
      View in: PubMed   Mentions: 4     Fields:    
    7. BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules. Cell Res. 2019 07; 29(7):562-578. Huang Y, Lin L, Liu X, Ye S, Yao PY, Wang W, Yang F, Gao X, Li J, Zhang Y, Zhang J, Yang Z, Liu X, Yang Z, Zang J, Teng M, Wang Z, Ruan K, Ding X, Li L, Cleveland DW, Zhang R, Yao X. PMID: 31201382.
      View in: PubMed   Mentions: 1     Fields:    
    8. DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres. Nat Cell Biol. 2019 06; 21(6):743-754. Nechemia-Arbely Y, Miga KH, Shoshani O, Aslanian A, McMahon MA, Lee AY, Fachinetti D, Yates JR, Ren B, Cleveland DW. PMID: 31160708.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment. J Clin Invest. 2019 05 21; 129(8):3103-3120. Jiang LL, Zhu B, Zhao Y, Li X, Liu T, Pina-Crespo J, Zhou L, Xu W, Rodriguez MJ, Yu H, Cleveland DW, Ravits J, Da Cruz S, Long T, Zhang D, Huang TY, Xu H. PMID: 31112137.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death. Neuron. 2019 04 17; 102(2):339-357.e7. Gasset-Rosa F, Lu S, Yu H, Chen C, Melamed Z, Guo L, Shorter J, Da Cruz S, Cleveland DW. PMID: 30853299.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    11. Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements. Nat Genet. 2019 04; 51(4):705-715. Ly P, Brunner SF, Shoshani O, Kim DH, Lan W, Pyntikova T, Flanagan AM, Behjati S, Page DC, Campbell PJ, Cleveland DW. PMID: 30833795.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    12. Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis. Elife. 2019 02 12; 8. Ling SC, Dastidar SG, Tokunaga S, Ho WY, Lim K, Ilieva H, Parone PA, Tyan SH, Tse TM, Chang JC, Platoshyn O, Bui NB, Bui A, Vetto A, Sun S, McAlonis-Downes M, Han JS, Swing D, Kapeli K, Yeo GW, Tessarollo L, Marsala M, Shaw CE, Tucker-Kellogg G, La Spada AR, Lagier-Tourenne C, Da Cruz S, Cleveland DW. PMID: 30747709.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    13. Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration. Nat Neurosci. 2019 02; 22(2):180-190. Melamed Z, López-Erauskin J, Baughn MW, Zhang O, Drenner K, Sun Y, Freyermuth F, McMahon MA, Beccari MS, Artates JW, Ohkubo T, Rodriguez M, Lin N, Wu D, Bennett CF, Rigo F, Da Cruz S, Ravits J, Lagier-Tourenne C, Cleveland DW. PMID: 30643298.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    14. Phosphorylation of CENP-A on serine 7 does not control centromere function. Nat Commun. 2019 01 11; 10(1):175. Barra V, Logsdon GA, Scelfo A, Hoffmann S, Hervé S, Aslanian A, Nechemia-Arbely Y, Cleveland DW, Black BE, Fachinetti D. PMID: 30635586.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    15. TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC. Nat Commun. 2018 10 19; 9(1):4354. Kim DH, Han JS, Ly P, Ye Q, McMahon MA, Myung K, Corbett KD, Cleveland DW. PMID: 30341343.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    16. ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS. Neuron. 2018 11 21; 100(4):816-830.e7. López-Erauskin J, Tadokoro T, Baughn MW, Myers B, McAlonis-Downes M, Chillon-Marinas C, Asiaban JN, Artates J, Bui AT, Vetto AP, Lee SK, Le AV, Sun Y, Jambeau M, Boubaker J, Swing D, Qiu J, Hicks GG, Ouyang Z, Fu XD, Tessarollo L, Ling SC, Parone PA, Shaw CE, Marsala M, Lagier-Tourenne C, Cleveland DW, Da Cruz S. PMID: 30344044.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    17. Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1. Cell. 2018 09 06; 174(6):1339-1341. Yu H, Cleveland DW. PMID: 30193106.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Probing Mitotic CENP-E Kinesin with the Tethered Cargo Motion Assay and Laser Tweezers. Biophys J. 2018 06 05; 114(11):2640-2652. Gudimchuk N, Tarasovetc EV, Mustyatsa V, Drobyshev AL, Vitre B, Cleveland DW, Ataullakhanov FI, Grishchuk EL. PMID: 29874614.
      View in: PubMed   Mentions:    Fields:    
    19. Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients. Acta Neuropathol. 2018 09; 136(3):425-443. Bennett CL, Dastidar SG, Ling SC, Malik B, Ashe T, Wadhwa M, Miller DB, Lee C, Mitchell MB, van Es MA, Grunseich C, Chen Y, Sopher BL, Greensmith L, Cleveland DW, La Spada AR. PMID: 29725819.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    20. Chemically Modified Cpf1-CRISPR RNAs Mediate Efficient Genome Editing in Mammalian Cells. Mol Ther. 2018 05 02; 26(5):1228-1240. McMahon MA, Prakash TP, Cleveland DW, Bennett CF, Rahdar M. PMID: 29650467.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    21. Chromosomal instability drives metastasis through a cytosolic DNA response. Nature. 2018 01 25; 553(7689):467-472. Bakhoum SF, Ngo B, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, Genovese G, Venkatesan S, Birkbak NJ, McGranahan N, Lundquist M, LaPlant Q, Healey JH, Elemento O, Chung CH, Lee NY, Imielenski M, Nanjangud G, Pe'er D, Cleveland DW, Powell SN, Lammerding J, Swanton C, Cantley LC. PMID: 29342134.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    22. C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2a phosphorylation. Nat Commun. 2018 01 04; 9(1):51. Cheng W, Wang S, Mestre AA, Fu C, Makarem A, Xian F, Hayes LR, Lopez-Gonzalez R, Drenner K, Jiang J, Cleveland DW, Sun S. PMID: 29302060.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    23. Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis. Acta Neuropathol. 2018 03; 135(3):459-474. Saberi S, Stauffer JE, Jiang J, Garcia SD, Taylor AE, Schulte D, Ohkubo T, Schloffman CL, Maldonado M, Baughn M, Rodriguez MJ, Pizzo D, Cleveland D, Ravits J. PMID: 29196813.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    24. Rethinking Unconventional Translation in Neurodegeneration. Cell. 2017 Nov 16; 171(5):994-1000. Gao FB, Richter JD, Cleveland DW. PMID: 29149615.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    25. Biological Spectrum of Amyotrophic Lateral Sclerosis Prions. Cold Spring Harb Perspect Med. 2017 Nov 01; 7(11). Polymenidou M, Cleveland DW. PMID: 28062558.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    26. Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis. Trends Cell Biol. 2017 12; 27(12):917-930. Ly P, Cleveland DW. PMID: 28899600.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    27. The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding. EMBO J. 2017 08 15; 36(16):2419-2434. Ye Q, Kim DH, Dereli I, Rosenberg SC, Hagemann G, Herzog F, Tóth A, Cleveland DW, Corbett KD. PMID: 28659378.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    28. Interrogating cell division errors using random and chromosome-specific missegregation approaches. Cell Cycle. 2017 Jul 03; 16(13):1252-1258. Ly P, Cleveland DW. PMID: 28650219.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    29. Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition. Nat Commun. 2017 06 09; 8:15775. Guo LY, Allu PK, Zandarashvili L, McKinley KL, Sekulic N, Dawicki-McKenna JM, Fachinetti D, Logsdon GA, Jamiolkowski RM, Cleveland DW, Cheeseman IM, Black BE. PMID: 28598437.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    30. Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport. Neuron. 2017 Apr 05; 94(1):48-57.e4. Gasset-Rosa F, Chillon-Marinas C, Goginashvili A, Atwal RS, Artates JW, Tabet R, Wheeler VC, Bang AG, Cleveland DW, Lagier-Tourenne C. PMID: 28384474.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    31. Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis. Acta Neuropathol. 2017 06; 133(6):907-922. Ditsworth D, Maldonado M, McAlonis-Downes M, Sun S, Seelman A, Drenner K, Arnold E, Ling SC, Pizzo D, Ravits J, Cleveland DW, Da Cruz S. PMID: 28357566.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    32. Misfolded SOD1 is not a primary component of sporadic ALS. Acta Neuropathol. 2017 07; 134(1):97-111. Da Cruz S, Bui A, Saberi S, Lee SK, Stauffer J, McAlonis-Downes M, Schulte D, Pizzo DP, Parone PA, Cleveland DW, Ravits J. PMID: 28247063.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    33. Human centromeric CENP-A chromatin is a homotypic, octameric nucleosome at all cell cycle points. J Cell Biol. 2017 03 06; 216(3):607-621. Nechemia-Arbely Y, Fachinetti D, Miga KH, Sekulic N, Soni GV, Kim DH, Wong AK, Lee AY, Nguyen K, Dekker C, Ren B, Black BE, Cleveland DW. PMID: 28235947.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    34. Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals. Dev Cell. 2017 02 06; 40(3):313-322.e5. Levine MS, Bakker B, Boeckx B, Moyett J, Lu J, Vitre B, Spierings DC, Lansdorp PM, Cleveland DW, Lambrechts D, Foijer F, Holland AJ. PMID: 28132847.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    35. CENP-A Modifications on Ser68 and Lys124 Are Dispensable for Establishment, Maintenance, and Long-Term Function of Human Centromeres. Dev Cell. 2017 01 09; 40(1):104-113. Fachinetti D, Logsdon GA, Abdullah A, Selzer EB, Cleveland DW, Black BE. PMID: 28073008.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    36. Bidirectional Transcriptional Inhibition as Therapy for ALS/FTD Caused by Repeat Expansion in C9orf72. Neuron. 2016 Dec 21; 92(6):1160-1163. Jiang J, Cleveland DW. PMID: 28009271.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    37. Gene therapy: Gene-editing therapy for neurological disease. Nat Rev Neurol. 2017 01; 13(1):7-9. McMahon MA, Cleveland DW. PMID: 27982043.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    38. Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining. Nat Cell Biol. 2017 Jan; 19(1):68-75. Ly P, Teitz LS, Kim DH, Shoshani O, Skaletsky H, Fachinetti D, Page DC, Cleveland DW. PMID: 27918550.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    39. CENP-A Is Dispensable for Mitotic Centromere Function after Initial Centromere/Kinetochore Assembly. Cell Rep. 2016 11 22; 17(9):2394-2404. Hoffmann S, Dumont M, Barra V, Ly P, Nechemia-Arbely Y, McMahon MA, Hervé S, Cleveland DW, Fachinetti D. PMID: 27880912.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    40. Decoding ALS: from genes to mechanism. Nature. 2016 Nov 10; 539(7628):197-206. Taylor JP, Brown RH, Cleveland DW. PMID: 27830784.
      View in: PubMed   Mentions: 221     Fields:    Translation:HumansAnimalsCells
    41. Potent spinal parenchymal AAV9-mediated gene delivery by subpial injection in adult rats and pigs. Mol Ther Methods Clin Dev. 2016; 3:16046. Miyanohara A, Kamizato K, Juhas S, Juhasova J, Navarro M, Marsala S, Lukacova N, Hruska-Plochan M, Curtis E, Gabel B, Ciacci J, Ahrens ET, Kaspar BK, Cleveland D, Marsala M. PMID: 27462649.
      View in: PubMed   Mentions:
    42. Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis. Free Radic Biol Med. 2016 08; 97:95-108. Seredenina T, Nayernia Z, Sorce S, Maghzal GJ, Filippova A, Ling SC, Basset O, Plastre O, Daali Y, Rushing EJ, Giordana MT, Cleveland DW, Aguzzi A, Stocker R, Krause KH, Jaquet V. PMID: 27212019.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    43. Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs. Neuron. 2016 05 04; 90(3):535-50. Jiang J, Zhu Q, Gendron TF, Saberi S, McAlonis-Downes M, Seelman A, Stauffer JE, Jafar-Nejad P, Drenner K, Schulte D, Chun S, Sun S, Ling SC, Myers B, Engelhardt J, Katz M, Baughn M, Platoshyn O, Marsala M, Watt A, Heyser CJ, Ard MC, De Muynck L, Daughrity LM, Swing DA, Tessarollo L, Jung CJ, Delpoux A, Utzschneider DT, Hedrick SM, de Jong PJ, Edbauer D, Van Damme P, Petrucelli L, Shaw CE, Bennett CF, Da Cruz S, Ravits J, Rigo F, Cleveland DW, Lagier-Tourenne C. PMID: 27112497.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    44. C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins. Nat Neurosci. 2016 05; 19(5):668-677. Zhang YJ, Gendron TF, Grima JC, Sasaguri H, Jansen-West K, Xu YF, Katzman RB, Gass J, Murray ME, Shinohara M, Lin WL, Garrett A, Stankowski JN, Daughrity L, Tong J, Perkerson EA, Yue M, Chew J, Castanedes-Casey M, Kurti A, Wang ZS, Liesinger AM, Baker JD, Jiang J, Lagier-Tourenne C, Edbauer D, Cleveland DW, Rademakers R, Boylan KB, Bu G, Link CD, Dickey CA, Rothstein JD, Dickson DW, Fryer JD, Petrucelli L. PMID: 26998601.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    45. CELL BIOLOGY. Disrupted nuclear import-export in neurodegeneration. Science. 2016 Jan 08; 351(6269):125-6. Da Cruz S, Cleveland DW. PMID: 26744395.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    46. Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism. Cell Metab. 2016 Feb 09; 23(2):280-91. Quaegebeur A, Segura I, Schmieder R, Verdegem D, Decimo I, Bifari F, Dresselaers T, Eelen G, Ghosh D, Davidson SM, Schoors S, Broekaert D, Cruys B, Govaerts K, De Legher C, Bouché A, Schoonjans L, Ramer MS, Hung G, Bossaert G, Cleveland DW, Himmelreich U, Voets T, Lemmens R, Bennett CF, Robberecht W, De Bock K, Dewerchin M, Ghesquière B, Fendt SM, Carmeliet P. PMID: 26774962.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    47. Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):E6993-7002. Sun S, Sun Y, Ling SC, Ferraiuolo L, McAlonis-Downes M, Zou Y, Drenner K, Wang Y, Ditsworth D, Tokunaga S, Kopelevich A, Kaspar BK, Lagier-Tourenne C, Cleveland DW. PMID: 26621731.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    48. Synthetic CRISPR RNA-Cas9-guided genome editing in human cells. Proc Natl Acad Sci U S A. 2015 Dec 22; 112(51):E7110-7. Rahdar M, McMahon MA, Prakash TP, Swayze EE, Bennett CF, Cleveland DW. PMID: 26589814.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    49. Epidermal development, growth control, and homeostasis in the face of centrosome amplification. Proc Natl Acad Sci U S A. 2015 Nov 17; 112(46):E6311-20. Kulukian A, Holland AJ, Vitre B, Naik S, Cleveland DW, Fuchs E. PMID: 26578791.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    50. Chronic centrosome amplification without tumorigenesis. Proc Natl Acad Sci U S A. 2015 Nov 17; 112(46):E6321-30. Vitre B, Holland AJ, Kulukian A, Shoshani O, Hirai M, Wang Y, Maldonado M, Cho T, Boubaker J, Swing DA, Tessarollo L, Evans SM, Fuchs E, Cleveland DW. PMID: 26578792.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    51. Novel clinical associations with specific C9ORF72 transcripts in patients with repeat expansions in C9ORF72. Acta Neuropathol. 2015 Dec; 130(6):863-76. van Blitterswijk M, Gendron TF, Baker MC, DeJesus-Hernandez M, Finch NA, Brown PH, Daughrity LM, Murray ME, Heckman MG, Jiang J, Lagier-Tourenne C, Edbauer D, Cleveland DW, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Petrucelli L, Boeve BF, Graff-Radford NR, Boylan KB, Dickson DW, Rademakers R. PMID: 26437865.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
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    289. AU-A, an RNA-binding activity distinct from hnRNP A1, is selective for AUUUA repeats and shuttles between the nucleus and the cytoplasm. Nucleic Acids Res. 1994 Jan 25; 22(2):238-46. Katz DA, Theodorakis NG, Cleveland DW, Lindsten T, Thompson CB. PMID: 8121809.
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    290. The rod domain of NF-L determines neurofilament architecture, whereas the end domains specify filament assembly and network formation. J Cell Biol. 1993 Dec; 123(6 Pt 1):1517-33. Heins S, Wong PC, Müller S, Goldie K, Cleveland DW, Aebi U. PMID: 8253847.
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    291. Neurofilaments are obligate heteropolymers in vivo. J Cell Biol. 1993 Sep; 122(6):1337-50. Lee MK, Xu Z, Wong PC, Cleveland DW. PMID: 8376466.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    292. Ferritin synthesis is controlled by iron-dependent translational derepression and by changes in synthesis/transport of nuclear ferritin RNAs. Proc Natl Acad Sci U S A. 1993 Aug 15; 90(16):7613-7. Coulson RM, Cleveland DW. PMID: 8356063.
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    293. Glycosylation of mammalian neurofilaments. Localization of multiple O-linked N-acetylglucosamine moieties on neurofilament polypeptides L and M. J Biol Chem. 1993 Aug 05; 268(22):16679-87. Dong DL, Xu ZS, Chevrier MR, Cotter RJ, Cleveland DW, Hart GW. PMID: 8344946.
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    294. Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease. Cell. 1993 Apr 09; 73(1):23-33. Xu Z, Cork LC, Griffin JW, Cleveland DW. PMID: 8462100.
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    295. NuMA is required for the proper completion of mitosis. J Cell Biol. 1993 Feb; 120(4):947-57. Compton DA, Cleveland DW. PMID: 8432734.
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    296. Involvement of neurofilaments in motor neuron disease. J Cell Sci Suppl. 1993; 17:101-8. Xu Z, Cork LC, Griffin JW, Cleveland DW. PMID: 8144684.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    297. Post-transcriptional processes. Curr Opin Cell Biol. 1992 Dec; 4(6):973-4. Cleveland DW, Hinnebusch AG. PMID: 1485967.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    298. CENP-E is a putative kinetochore motor that accumulates just before mitosis. Nature. 1992 Oct 08; 359(6395):536-9. Yen TJ, Li G, Schaar BT, Szilak I, Cleveland DW. PMID: 1406971.
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    299. Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a > 20S degradation complex. Genes Dev. 1992 Oct; 6(10):1927-39. Savant-Bhonsale S, Cleveland DW. PMID: 1398070.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    300. Gamma-tubulin is a centrosomal protein required for cell cycle-dependent microtubule nucleation. Nature. 1992 Mar 05; 356(6364):80-3. Joshi HC, Palacios MJ, McNamara L, Cleveland DW. PMID: 1538786.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    301. Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis. J Cell Biol. 1992 Mar; 116(6):1395-408. Compton DA, Szilak I, Cleveland DW. PMID: 1541636.
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    302. Physical evidence for cotranslational regulation of beta-tubulin mRNA degradation. Mol Cell Biol. 1992 Feb; 12(2):791-9. Theodorakis NG, Cleveland DW. PMID: 1732744.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    303. Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein. J Cell Biol. 1991 Dec; 115(6):1639-50. Gill SR, Schroer TA, Szilak I, Steuer ER, Sheetz MP, Cleveland DW. PMID: 1836789.
      View in: PubMed   Mentions: 167     Fields:    Translation:AnimalsCells
    304. Slow axonal transport models come full circle: evidence that microtubule sliding mediates axon elongation and tubulin transport. Cell. 1991 Nov 01; 67(3):453-6. Cleveland DW, Hoffman PN. PMID: 1718604.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    305. Neuronal and glial cytoskeletons. Curr Opin Neurobiol. 1991 Oct; 1(3):346-53. Cleveland DW, Hoffman PN. PMID: 1821676.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    306. CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase. EMBO J. 1991 May; 10(5):1245-54. Yen TJ, Compton DA, Wise D, Zinkowski RP, Brinkley BR, Earnshaw WC, Cleveland DW. PMID: 2022189.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansCells
    307. Identification of novel centromere/kinetochore-associated proteins using monoclonal antibodies generated against human mitotic chromosome scaffolds. J Cell Biol. 1991 Mar; 112(6):1083-97. Compton DA, Yen TJ, Cleveland DW. PMID: 1999466.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    308. Ability of the c-mos product to associate with and phosphorylate tubulin. Science. 1991 Feb 08; 251(4994):671-5. Zhou RP, Oskarsson M, Paules RS, Schulz N, Cleveland D, Vande Woude GF. PMID: 1825142.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    309. Involvement of neurofilaments in the radial growth of axons. J Cell Sci Suppl. 1991; 15:85-95. Cleveland DW, Monteiro MJ, Wong PC, Gill SR, Gearhart JD, Hoffman PN. PMID: 1824110.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    310. Characterization of dominant and recessive assembly-defective mutations in mouse neurofilament NF-M. J Cell Biol. 1990 Nov; 111(5 Pt 1):1987-2003. Wong PC, Cleveland DW. PMID: 2121743.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    311. Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit. J Cell Biol. 1990 Nov; 111(5 Pt 1):2005-19. Gill SR, Wong PC, Monteiro MJ, Cleveland DW. PMID: 2121744.
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    312. Expression of NF-L in both neuronal and nonneuronal cells of transgenic mice: increased neurofilament density in axons without affecting caliber. J Cell Biol. 1990 Oct; 111(4):1543-57. Monteiro MJ, Hoffman PN, Gearhart JD, Cleveland DW. PMID: 2120242.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    313. Use of molecular cloning methods to map the distribution of epitopes on topoisomerase I (Scl-70) recognized by sera of scleroderma patients. Arthritis Rheum. 1990 Oct; 33(10):1501-11. D'Arpa P, White-Cooper H, Cleveland DW, Rothfield NF, Earnshaw WC. PMID: 1699543.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    314. Solid adenoid cystic carcinoma of the maxilla. Oral Surg Oral Med Oral Pathol. 1990 Apr; 69(4):470-8. Cleveland D, Abrams AM, Melrose RJ, Handlers JP. PMID: 2158031.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    315. Lung abscess secondary to xanthogranulomatous pyelonephritis. Thorax. 1990 Apr; 45(4):297-9. Pandya K, Wilcox J, Khaw H, Cleveland D, Sharma OP. PMID: 2356557.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    316. Tubulin site interpretation. Nature. 1990 Mar 29; 344(6265):389. Cleveland DW, Joshi HC, Murphy DB. PMID: 2138712.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    317. Microtubule MAPping. Cell. 1990 Mar 09; 60(5):701-2. Cleveland DW. PMID: 2107023.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    318. A rapidly rearranging retrotransposon within the miniexon gene locus of Crithidia fasciculata. Mol Cell Biol. 1990 Feb; 10(2):615-24. Gabriel A, Yen TJ, Schwartz DC, Smith CL, Boeke JD, Sollner-Webb B, Cleveland DW. PMID: 2153919.
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    319. The expression and posttranslational modification of a neuron-specific beta-tubulin isotype during chick embryogenesis. Cell Motil Cytoskeleton. 1990; 17(2):118-32. Lee MK, Tuttle JB, Rebhun LI, Cleveland DW, Frankfurter A. PMID: 2257630.
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    320. Diversity among tubulin subunits: toward what functional end? Cell Motil Cytoskeleton. 1990; 16(3):159-63. Joshi HC, Cleveland DW. PMID: 2194680.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    321. In vivo discrimination among beta-tubulin isotypes: selective degradation of a type IV beta-tubulin isotype following overexpression in cultured animal cells. New Biol. 1990 Jan; 2(1):66-76. Sisodia SS, Gay DA, Cleveland DW. PMID: 2078553.
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    322. Gene regulation through messenger RNA stability. Curr Opin Cell Biol. 1989 Dec; 1(6):1148-53. Cleveland DW. PMID: 2699801.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    323. Multiple determinants of eukaryotic mRNA stability. New Biol. 1989 Nov; 1(2):121-6. Cleveland DW, Yen TJ. PMID: 2518709.
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    324. Autoregulatory control of beta-tubulin mRNA stability is linked to translation elongation. Proc Natl Acad Sci U S A. 1989 Aug; 86(15):5763-7. Gay DA, Sisodia SS, Cleveland DW. PMID: 2762294.
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    325. Differential utilization of beta-tubulin isotypes in differentiating neurites. J Cell Biol. 1989 Aug; 109(2):663-73. Joshi HC, Cleveland DW. PMID: 2503525.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    326. Autoregulated control of tubulin synthesis in animal cells. Curr Opin Cell Biol. 1989 Feb; 1(1):10-4. Cleveland DW. PMID: 2629858.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    327. Expression of NF-L and NF-M in fibroblasts reveals coassembly of neurofilament and vimentin subunits. J Cell Biol. 1989 Feb; 108(2):579-93. Monteiro MJ, Cleveland DW. PMID: 2493000.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    328. Use of DNA transfection to analyze gene regulation and function in animal cells: dissection of the tubulin multigene family. Cell Motil Cytoskeleton. 1989; 14(1):147-55. Cleveland DW. PMID: 2684421.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    329. Autoregulated instability of tubulin mRNAs: a novel eukaryotic regulatory mechanism. Trends Biochem Sci. 1988 Sep; 13(9):339-43. Cleveland DW. PMID: 3072712.
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    330. Autoregulated instability of beta-tubulin mRNAs by recognition of the nascent amino terminus of beta-tubulin. Nature. 1988 Aug 18; 334(6183):580-5. Yen TJ, Machlin PS, Cleveland DW. PMID: 3405308.
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    331. Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration: induction of a specific beta-tubulin isotype. Proc Natl Acad Sci U S A. 1988 Jun; 85(12):4530-3. Hoffman PN, Cleveland DW. PMID: 3132717.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    332. A survey of the alpha-tubulin gene family in chicken: unexpected sequence heterogeneity in the polypeptides encoded by five expressed genes. EMBO J. 1988 Apr; 7(4):931-40. Pratt LF, Cleveland DW. PMID: 3267229.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    333. cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment. Proc Natl Acad Sci U S A. 1988 Apr; 85(8):2543-7. D'Arpa P, Machlin PS, Ratrie H, Rothfield NF, Cleveland DW, Earnshaw WC. PMID: 2833744.
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    334. Autoregulated changes in stability of polyribosome-bound beta-tubulin mRNAs are specified by the first 13 translated nucleotides. Mol Cell Biol. 1988 Mar; 8(3):1224-35. Yen TJ, Gay DA, Pachter JS, Cleveland DW. PMID: 2835666.
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    335. Sequence of chicken c beta 7 tubulin. Analysis of a complete set of vertebrate beta-tubulin isotypes. J Mol Biol. 1988 Feb 05; 199(3):439-46. Monteiro MJ, Cleveland DW. PMID: 3351937.
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    336. Evidence of discontinuous transcription in the trypanosomatid Crithidia fasciculata. J Biol Chem. 1987 Nov 25; 262(33):16192-9. Gabriel A, Sisodia SS, Cleveland DW. PMID: 3680249.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    337. In vivo coassembly of a divergent beta-tubulin subunit (c beta 6) into microtubules of different function. J Cell Biol. 1987 Nov; 105(5):2179-90. Joshi HC, Yen TJ, Cleveland DW. PMID: 3316249.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    338. Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs. Cell. 1987 Oct 23; 51(2):283-92. Pachter JS, Yen TJ, Cleveland DW. PMID: 2444342.
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    339. The sequence and expression of the divergent beta-tubulin in chicken erythrocytes. J Biol Chem. 1987 Oct 15; 262(29):14305-12. Murphy DB, Wallis KT, Machlin PS, Ratrie H, Cleveland DW. PMID: 2888766.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    340. Specificity of RNA maturation pathways: RNAs transcribed by RNA polymerase III are not substrates for splicing or polyadenylation. Mol Cell Biol. 1987 Oct; 7(10):3602-12. Sisodia SS, Sollner-Webb B, Cleveland DW. PMID: 3683396.
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    341. In vivo microtubules are copolymers of available beta-tubulin isotypes: localization of each of six vertebrate beta-tubulin isotypes using polyclonal antibodies elicited by synthetic peptide antigens. J Cell Biol. 1987 Oct; 105(4):1707-20. Lopata MA, Cleveland DW. PMID: 3312237.
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    342. Sequences that confer beta-tubulin autoregulation through modulated mRNA stability reside within exon 1 of a beta-tubulin mRNA. Cell. 1987 Aug 28; 50(5):671-9. Gay DA, Yen TJ, Lau JT, Cleveland DW. PMID: 3621343.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    343. Analysis of anticentromere autoantibodies using cloned autoantigen CENP-B. Proc Natl Acad Sci U S A. 1987 Jul; 84(14):4979-83. Earnshaw WC, Machlin PS, Bordwell BJ, Rothfield NF, Cleveland DW. PMID: 2440036.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    344. Neurofilament gene expression: a major determinant of axonal caliber. Proc Natl Acad Sci U S A. 1987 May; 84(10):3472-6. Hoffman PN, Cleveland DW, Griffin JW, Landes PW, Cowan NJ, Price DL. PMID: 3472217.
      View in: PubMed   Mentions: 127     Fields:    Translation:AnimalsCells
    345. Molecular cloning of cDNA for CENP-B, the major human centromere autoantigen. J Cell Biol. 1987 Apr; 104(4):817-29. Earnshaw WC, Sullivan KF, Machlin PS, Cooke CA, Kaiser DA, Pollard TD, Rothfield NF, Cleveland DW. PMID: 2435739.
      View in: PubMed   Mentions: 149     Fields:    Translation:HumansCells
    346. A combination of RNase H and S1 nuclease circumvents an artefact inherent to conventional S1 analysis of RNA splicing. Nucleic Acids Res. 1987 Mar 11; 15(5):1995-2011. Sisodia SS, Cleveland DW, Sollner-Webb B. PMID: 3031584.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    347. The multitubulin hypothesis revisited: what have we learned? J Cell Biol. 1987 Mar; 104(3):381-3. Cleveland DW. PMID: 3546332.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    348. A divergent testis-specific alpha-tubulin isotype that does not contain a coded C-terminal tyrosine. Mol Cell Biol. 1987 Jan; 7(1):552-5. Pratt LF, Okamura S, Cleveland DW. PMID: 3561402.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    349. Sequence and expression of the chicken beta 5- and beta 4-tubulin genes define a pair of divergent beta-tubulins with complementary patterns of expression. Mol Cell Biol. 1986 Dec; 6(12):4409-18. Sullivan KF, Havercroft JC, Machlin PS, Cleveland DW. PMID: 3025656.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    350. Sequence and expression of the chicken beta 3 tubulin gene. A vertebrate testis beta-tubulin isotype. J Biol Chem. 1986 Oct 05; 261(28):13317-22. Sullivan KF, Machlin PS, Ratrie H, Cleveland DW. PMID: 3759966.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    351. RNA polymerase specificity of mRNA production and enhancer action. Proc Natl Acad Sci U S A. 1986 Sep; 83(18):6677-81. Lopata MA, Cleveland DW, Sollner-Webb B. PMID: 3462718.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    352. Identification of conserved isotype-defining variable region sequences for four vertebrate beta tubulin polypeptide classes. Proc Natl Acad Sci U S A. 1986 Jun; 83(12):4327-31. Sullivan KF, Cleveland DW. PMID: 3459176.
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    353. Reconstruction of tubulin gene regulation in cultured mammalian cells. Ann N Y Acad Sci. 1986; 466:75-88. Lau JT, Pittenger MF, Havercroft JC, Cleveland DW. PMID: 3460447.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    354. Retention of autoregulatory control of tubulin synthesis in cytoplasts: demonstration of a cytoplasmic mechanism that regulates the level of tubulin expression. J Cell Biol. 1985 Nov; 101(5 Pt 1):1941-52. Pittenger MF, Cleveland DW. PMID: 4055901.
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    355. Apparent gene conversion between beta-tubulin genes yields multiple regulatory pathways for a single beta-tubulin polypeptide isotype. Mol Cell Biol. 1985 Sep; 5(9):2454-65. Sullivan KF, Lau JT, Cleveland DW. PMID: 3837190.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    356. Reconstruction of appropriate tubulin and actin gene regulation after transient transfection of cloned beta-tubulin and beta-actin genes. Mol Cell Biol. 1985 Jul; 5(7):1611-20. Lau JT, Pittenger MF, Cleveland DW. PMID: 4022009.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    357. Molecular biology and genetics of tubulin. Annu Rev Biochem. 1985; 54:331-65. Cleveland DW, Sullivan KF. PMID: 3896122.
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    358. Programmed expression of beta-tubulin genes during development and differentiation of the chicken. J Cell Biol. 1984 Dec; 99(6):1927-35. Havercroft JC, Cleveland DW. PMID: 6094589.
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    359. Sequence of a highly divergent beta tubulin gene reveals regional heterogeneity in the beta tubulin polypeptide. J Cell Biol. 1984 Nov; 99(5):1754-60. Sullivan KF, Cleveland DW. PMID: 6490718.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    360. Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. Mol Cell Biol. 1983 Oct; 3(10):1738-45. Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW. PMID: 6646120.
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    361. Elevation of tubulin levels by microinjection suppresses new tubulin synthesis. Nature. 1983 Oct 20-26; 305(5936):738-40. Cleveland DW, Pittenger MF, Feramisco JR. PMID: 6633643.
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    362. Is apparent autoregulatory control of tubulin synthesis nontranscriptionally regulated? J Cell Biol. 1983 Sep; 97(3):919-24. Cleveland DW, Havercroft JC. PMID: 6885926.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    363. The tubulins: from DNA to RNA to protein and back again. Cell. 1983 Sep; 34(2):330-2. Cleveland DW. PMID: 6193888.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    364. Glyceraldehyde 3-phosphate dehydrogenase protein and mRNA are both differentially expressed in adult chickens but not chick embryos. Nucleic Acids Res. 1983 May 25; 11(10):3301-15. Milner RJ, Brow MD, Cleveland DW, Shinnick TM, Sutcliffe JG. PMID: 6687938.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    365. Four unique genes required for beta tubulin expression in vertebrates. Cell. 1983 Mar; 32(3):713-24. Lopata MA, Havercroft JC, Chow LT, Cleveland DW. PMID: 6831558.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    366. Autoregulatory control of expression of alpha and beta tubulin. J Submicrosc Cytol. 1983 Jan; 15(1):353-8. Cleveland DW, Pittenger MF, Lopata MA. PMID: 6188853.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    367. Treadmilling of tubulin and actin. Cell. 1982 Apr; 28(4):689-91. Cleveland DW. PMID: 7046949.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    368. Autoregulatory control of the expression of alpha- and beta-tubulins: implications for microtubule assembly. Cold Spring Harb Symp Quant Biol. 1982; 46 Pt 1:171-83. Cleveland D, Kirschner M. PMID: 6286212.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    369. Probing the function of the eucaryotic 5' cap structure by using a monoclonal antibody directed against cap-binding proteins. Cell. 1981 Dec; 27(3 Pt 2):563-72. Sonenberg N, Guertin D, Cleveland D, Trachsel H. PMID: 6101207.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    370. Two distinct classes of keratin genes and their evolutionary significance. Cell. 1981 Nov; 27(1 Pt 2):75-84. Fuchs EV, Coppock SM, Green H, Cleveland DW. PMID: 6173133.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    371. Unpolymerized tubulin modulates the level of tubulin mRNAs. Cell. 1981 Aug; 25(2):537-46. Cleveland DW, Lopata MA, Sherline P, Kirschner MW. PMID: 6116546.
      View in: PubMed   Mentions: 108     Fields:    Translation:AnimalsCells
    372. Nucleotide and corresponding amino acid sequences encoded by alpha and beta tubulin mRNAs. Nature. 1981 Feb 19; 289(5799):650-5. Valenzuela P, Quiroga M, Zaldivar J, Rutter WJ, Kirschner MW, Cleveland DW. PMID: 7464932.
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    373. A dispersed multigene family encoding tubulin in Drosophila melanogaster. Cell. 1980 Dec; 22(3):845-54. Sánchez F, Natzle JE, Cleveland DW, Kirschner MW, McCarthy BJ. PMID: 6780200.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    374. Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell. 1980 May; 20(1):95-105. Cleveland DW, Lopata MA, MacDonald RJ, Cowan NJ, Rutter WJ, Kirschner MW. PMID: 6893015.
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    375. Conservation of microtubule associated proteins. Isolation and characterization of tau and the high molecular weight microtubule associated protein from chicken brain and from mouse fibroblasts and comparison to the corresponding mammalian brain proteins. J Biol Chem. 1979 Dec 25; 254(24):12670-8. Cleveland DW, Spiegelman BM, Kirschner MW. PMID: 227904.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    376. Isolation of separate mRNAs for alpha- and beta-tubulin and characterization of the corresponding in vitro translation products. Cell. 1978 Nov; 15(3):1021-31. Cleveland DW, Kirschner MW, Cowan NJ. PMID: 728983.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    377. Intracellular localization of the high molecular weight microtubule accessory protein by indirect immunofluorescence. J Cell Biol. 1978 Mar; 76(3):781-6. Connolly JA, Kalnins VI, Cleveland DW, Kirschner MW. PMID: 344329.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    378. Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. J Mol Biol. 1977 Oct 25; 116(2):207-25. Cleveland DW, Hwo SY, Kirschner MW. PMID: 599557.
      View in: PubMed   Mentions: 194     Fields:    Translation:Cells
    379. Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly. J Mol Biol. 1977 Oct 25; 116(2):227-47. Cleveland DW, Hwo SY, Kirschner MW. PMID: 146092.
      View in: PubMed   Mentions: 179     Fields:    Translation:Cells
    380. Immunoflourescent staining of cytoplasmic and spindle microtubules in mouse fibroblasts with antibody to tau protein. Proc Natl Acad Sci U S A. 1977 Jun; 74(6):2437-40. Connolly JA, Kalnins VI, Cleveland DW, Kirschner MW. PMID: 329285.
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    381. Tubulin requires tau for growth onto microtubule initiating sites. Proc Natl Acad Sci U S A. 1976 Nov; 73(11):4070-4. Witman GB, Cleveland DW, Weingarten MD, Kirschner MW. PMID: 1069293.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
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