Loading...

Don Cleveland

Title(s)Professor, Cellular and Molecular Medicine
SchoolHealth Sciences
Phone858-534-7811
vCardDownload vCard

    Collapse Overview 
    Collapse Overview
    Cleveland is interested in the genes and proteins involved in mitotic spindle assembly and faithful chromosome segregation just prior to division. This process is particularly relevant to the development of cancer because it is thought that cancer cells mis-segregate chromosomes due to errors in mitosis resulting in aneuploidy. The major pathway guarding against whole chromosome mis-segregation is the mitotic checkpoint, a cell cycle control mechanism in which the centromeres of unattached chromosomes generate an inhibitor that blocks cyclin B degradation and advance across mitosis. The antitumor drug taxol is effective by chronically activating this checkpoint. In the past year, starting from all purified components Cleveland’s efforts have reconstructed mitotic checkpoint signaling in vitro. Additionally, abnormalities in number of microtubule organizing centers (centrosomes) can promote errors in spindle formation that lead to subsequent chromosome missegregation and extra centrosomes are associated with many cancers. Like DNA, centrosomes are duplicated only once each cell cycle. The duplication process is governed by polo-like kinase 4 (Plk4). Cleveland’s recent efforts identified how centrosome over-replication is blocked: kinase-mediated, autoregulated instability of Plk4 acts to self-limit Plk4 activity so as to prevent centrosome amplification.

    Clinical Interests
    - Cancer Biology
    - Amyotrophic lateral sclerosis

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of chromosome segregation, aneuploidy, and tumorigenesis
    NIH/NIGMS R35GM122476May 1, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Junior Faculty and Postdoctoral Fellows Career Development Workshop
    NIH/NIGMS R13GM111037Sep 15, 2014 - Aug 31, 2015
    Role: Principal Investigator
    ALS therapies and genomics for mutant TDP-43 and TLS/FUS
    NIH/NINDS RC1NS069144Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Delivery of therapeutic genes in motor neuron disease
    NIH/NINDS RC2NS069476Sep 30, 2009 - Aug 31, 2012
    Role: Co-Principal Investigator
    Mammalian Centromere Assembly
    NIH/NIGMS R01GM074150Feb 1, 2006 - Aug 31, 2018
    Role: Principal Investigator
    6TH INTERNATIONAL CONGRESS ON CELL BIOLOGY
    NIH/NCI R13CA072388Sep 30, 1996 - Sep 29, 1997
    Role: Principal Investigator
    Disease mechanism in ALS and frontotemporal dementia
    NIH/NINDS R01NS027036Apr 1, 1989 - Aug 31, 2022
    Role: Principal Investigator
    Neurofilaments, SOD1 and Motor Neuron Diseases
    NIH/NINDS R37NS027036Apr 1, 1989 - May 31, 2012
    Role: Principal Investigator
    MICROTUBULE REGULATION: CONTROL OF EXPRESSION OF TUBULI
    NIH/NICHD K04HD000504Sep 30, 1982 - Aug 31, 1987
    Role: Principal Investigator
    Guarding the Genome: Aneuploidy and tumorigenesis
    NIH/NIGMS R01GM029513Jul 1, 1981 - Aug 31, 2020
    Role: Principal Investigator
    MICROTUBULE REGULATION
    NIH/NIGMS R37GM029513Jul 1, 1981 - Jun 30, 2004
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Cheng W, Wang S, Zhang Z, Morgens DW, Hayes LR, Lee S, Portz B, Xie Y, Nguyen BV, Haney MS, Yan S, Dong D, Coyne AN, Yang J, Xian F, Cleveland DW, Qiu Z, Rothstein JD, Shorter J, Gao FB, Bassik MC, Sun S. CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation. Neuron. 2019 Sep 19. PMID: 31587919.
      View in: PubMed
    2. Bennett CF, Krainer AR, Cleveland DW. Antisense Oligonucleotide Therapies for Neurodegenerative Diseases. Annu Rev Neurosci. 2019 Jul 08; 42:385-406. PMID: 31283897.
      View in: PubMed
    3. Huang Y, Lin L, Liu X, Ye S, Yao PY, Wang W, Yang F, Gao X, Li J, Zhang Y, Zhang J, Yang Z, Liu X, Yang Z, Zang J, Teng M, Wang Z, Ruan K, Ding X, Li L, Cleveland DW, Zhang R, Yao X. BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules. Cell Res. 2019 Jul; 29(7):562-578. PMID: 31201382.
      View in: PubMed
    4. Nechemia-Arbely Y, Miga KH, Shoshani O, Aslanian A, McMahon MA, Lee AY, Fachinetti D, Yates JR, Ren B, Cleveland DW. DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres. Nat Cell Biol. 2019 06; 21(6):743-754. PMID: 31160708.
      View in: PubMed
    5. Jiang LL, Zhu B, Zhao Y, Li X, Liu T, Pina-Crespo J, Zhou L, Xu W, Rodriguez MJ, Yu H, Cleveland DW, Ravits J, Da Cruz S, Long T, Zhang D, Huang TY, Xu H. Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment. J Clin Invest. 2019 05 21; 129(8):3103-3120. PMID: 31112137.
      View in: PubMed
    6. Gasset-Rosa F, Lu S, Yu H, Chen C, Melamed Z, Guo L, Shorter J, Da Cruz S, Cleveland DW. Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death. Neuron. 2019 Apr 17; 102(2):339-357.e7. PMID: 30853299.
      View in: PubMed
    7. Ly P, Brunner SF, Shoshani O, Kim DH, Lan W, Pyntikova T, Flanagan AM, Behjati S, Page DC, Campbell PJ, Cleveland DW. Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements. Nat Genet. 2019 04; 51(4):705-715. PMID: 30833795.
      View in: PubMed
    8. Ling SC, Dastidar SG, Tokunaga S, Ho WY, Lim K, Ilieva H, Parone PA, Tyan SH, Tse TM, Chang JC, Platoshyn O, Bui NB, Bui A, Vetto A, Sun S, McAlonis-Downes M, Han JS, Swing D, Kapeli K, Yeo GW, Tessarollo L, Marsala M, Shaw CE, Tucker-Kellogg G, La Spada AR, Lagier-Tourenne C, Da Cruz S, Cleveland DW. Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis. Elife. 2019 Feb 12; 8. PMID: 30747709.
      View in: PubMed
    9. Melamed Z, López-Erauskin J, Baughn MW, Zhang O, Drenner K, Sun Y, Freyermuth F, McMahon MA, Beccari MS, Artates JW, Ohkubo T, Rodriguez M, Lin N, Wu D, Bennett CF, Rigo F, Da Cruz S, Ravits J, Lagier-Tourenne C, Cleveland DW. Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration. Nat Neurosci. 2019 02; 22(2):180-190. PMID: 30643298.
      View in: PubMed
    10. Barra V, Logsdon GA, Scelfo A, Hoffmann S, Hervé S, Aslanian A, Nechemia-Arbely Y, Cleveland DW, Black BE, Fachinetti D. Phosphorylation of CENP-A on serine 7 does not control centromere function. Nat Commun. 2019 01 11; 10(1):175. PMID: 30635586.
      View in: PubMed
    11. Kim DH, Han JS, Ly P, Ye Q, McMahon MA, Myung K, Corbett KD, Cleveland DW. TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC. Nat Commun. 2018 10 19; 9(1):4354. PMID: 30341343.
      View in: PubMed
    12. López-Erauskin J, Tadokoro T, Baughn MW, Myers B, McAlonis-Downes M, Chillon-Marinas C, Asiaban JN, Artates J, Bui AT, Vetto AP, Lee SK, Le AV, Sun Y, Jambeau M, Boubaker J, Swing D, Qiu J, Hicks GG, Ouyang Z, Fu XD, Tessarollo L, Ling SC, Parone PA, Shaw CE, Marsala M, Lagier-Tourenne C, Cleveland DW, Da Cruz S. ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS. Neuron. 2018 11 21; 100(4):816-830.e7. PMID: 30344044.
      View in: PubMed
    13. Yu H, Cleveland DW. Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1. Cell. 2018 09 06; 174(6):1339-1341. PMID: 30193106.
      View in: PubMed
    14. Gudimchuk N, Tarasovetc EV, Mustyatsa V, Drobyshev AL, Vitre B, Cleveland DW, Ataullakhanov FI, Grishchuk EL. Probing Mitotic CENP-E Kinesin with the Tethered Cargo Motion Assay and Laser Tweezers. Biophys J. 2018 06 05; 114(11):2640-2652. PMID: 29874614.
      View in: PubMed
    15. Bennett CL, Dastidar SG, Ling SC, Malik B, Ashe T, Wadhwa M, Miller DB, Lee C, Mitchell MB, van Es MA, Grunseich C, Chen Y, Sopher BL, Greensmith L, Cleveland DW, La Spada AR. Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients. Acta Neuropathol. 2018 09; 136(3):425-443. PMID: 29725819.
      View in: PubMed
    16. McMahon MA, Prakash TP, Cleveland DW, Bennett CF, Rahdar M. Chemically Modified Cpf1-CRISPR RNAs Mediate Efficient Genome Editing in Mammalian Cells. Mol Ther. 2018 05 02; 26(5):1228-1240. PMID: 29650467.
      View in: PubMed
    17. Bakhoum SF, Ngo B, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, Genovese G, Venkatesan S, Birkbak NJ, McGranahan N, Lundquist M, LaPlant Q, Healey JH, Elemento O, Chung CH, Lee NY, Imielenski M, Nanjangud G, Pe'er D, Cleveland DW, Powell SN, Lammerding J, Swanton C, Cantley LC. Chromosomal instability drives metastasis through a cytosolic DNA response. Nature. 2018 01 25; 553(7689):467-472. PMID: 29342134.
      View in: PubMed
    18. Cheng W, Wang S, Mestre AA, Fu C, Makarem A, Xian F, Hayes LR, Lopez-Gonzalez R, Drenner K, Jiang J, Cleveland DW, Sun S. C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2a phosphorylation. Nat Commun. 2018 01 04; 9(1):51. PMID: 29302060.
      View in: PubMed
    19. Saberi S, Stauffer JE, Jiang J, Garcia SD, Taylor AE, Schulte D, Ohkubo T, Schloffman CL, Maldonado M, Baughn M, Rodriguez MJ, Pizzo D, Cleveland D, Ravits J. Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis. Acta Neuropathol. 2018 03; 135(3):459-474. PMID: 29196813.
      View in: PubMed
    20. Gao FB, Richter JD, Cleveland DW. Rethinking Unconventional Translation in Neurodegeneration. Cell. 2017 Nov 16; 171(5):994-1000. PMID: 29149615.
      View in: PubMed
    21. Polymenidou M, Cleveland DW. Biological Spectrum of Amyotrophic Lateral Sclerosis Prions. Cold Spring Harb Perspect Med. 2017 Nov 01; 7(11). PMID: 28062558.
      View in: PubMed
    22. Ly P, Cleveland DW. Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis. Trends Cell Biol. 2017 12; 27(12):917-930. PMID: 28899600.
      View in: PubMed
    23. Ye Q, Kim DH, Dereli I, Rosenberg SC, Hagemann G, Herzog F, Tóth A, Cleveland DW, Corbett KD. The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding. EMBO J. 2017 08 15; 36(16):2419-2434. PMID: 28659378.
      View in: PubMed
    24. Ly P, Cleveland DW. Interrogating cell division errors using random and chromosome-specific missegregation approaches. Cell Cycle. 2017 Jul 03; 16(13):1252-1258. PMID: 28650219.
      View in: PubMed
    25. Guo LY, Allu PK, Zandarashvili L, McKinley KL, Sekulic N, Dawicki-McKenna JM, Fachinetti D, Logsdon GA, Jamiolkowski RM, Cleveland DW, Cheeseman IM, Black BE. Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition. Nat Commun. 2017 06 09; 8:15775. PMID: 28598437.
      View in: PubMed
    26. Gasset-Rosa F, Chillon-Marinas C, Goginashvili A, Atwal RS, Artates JW, Tabet R, Wheeler VC, Bang AG, Cleveland DW, Lagier-Tourenne C. Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport. Neuron. 2017 Apr 05; 94(1):48-57.e4. PMID: 28384474.
      View in: PubMed
    27. Ditsworth D, Maldonado M, McAlonis-Downes M, Sun S, Seelman A, Drenner K, Arnold E, Ling SC, Pizzo D, Ravits J, Cleveland DW, Da Cruz S. Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis. Acta Neuropathol. 2017 06; 133(6):907-922. PMID: 28357566.
      View in: PubMed
    28. Da Cruz S, Bui A, Saberi S, Lee SK, Stauffer J, McAlonis-Downes M, Schulte D, Pizzo DP, Parone PA, Cleveland DW, Ravits J. Misfolded SOD1 is not a primary component of sporadic ALS. Acta Neuropathol. 2017 07; 134(1):97-111. PMID: 28247063.
      View in: PubMed
    29. Nechemia-Arbely Y, Fachinetti D, Miga KH, Sekulic N, Soni GV, Kim DH, Wong AK, Lee AY, Nguyen K, Dekker C, Ren B, Black BE, Cleveland DW. Human centromeric CENP-A chromatin is a homotypic, octameric nucleosome at all cell cycle points. J Cell Biol. 2017 03 06; 216(3):607-621. PMID: 28235947.
      View in: PubMed
    30. Levine MS, Bakker B, Boeckx B, Moyett J, Lu J, Vitre B, Spierings DC, Lansdorp PM, Cleveland DW, Lambrechts D, Foijer F, Holland AJ. Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals. Dev Cell. 2017 02 06; 40(3):313-322.e5. PMID: 28132847.
      View in: PubMed
    31. Fachinetti D, Logsdon GA, Abdullah A, Selzer EB, Cleveland DW, Black BE. CENP-A Modifications on Ser68 and Lys124 Are Dispensable for Establishment, Maintenance, and Long-Term Function of Human Centromeres. Dev Cell. 2017 01 09; 40(1):104-113. PMID: 28073008.
      View in: PubMed
    32. Jiang J, Cleveland DW. Bidirectional Transcriptional Inhibition as Therapy for ALS/FTD Caused by Repeat Expansion in C9orf72. Neuron. 2016 Dec 21; 92(6):1160-1163. PMID: 28009271.
      View in: PubMed
    33. McMahon MA, Cleveland DW. Gene therapy: Gene-editing therapy for neurological disease. Nat Rev Neurol. 2017 01; 13(1):7-9. PMID: 27982043.
      View in: PubMed
    34. Ly P, Teitz LS, Kim DH, Shoshani O, Skaletsky H, Fachinetti D, Page DC, Cleveland DW. Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining. Nat Cell Biol. 2017 Jan; 19(1):68-75. PMID: 27918550.
      View in: PubMed
    35. Hoffmann S, Dumont M, Barra V, Ly P, Nechemia-Arbely Y, McMahon MA, Hervé S, Cleveland DW, Fachinetti D. CENP-A Is Dispensable for Mitotic Centromere Function after Initial Centromere/Kinetochore Assembly. Cell Rep. 2016 11 22; 17(9):2394-2404. PMID: 27880912.
      View in: PubMed
    36. Taylor JP, Brown RH, Cleveland DW. Decoding ALS: from genes to mechanism. Nature. 2016 Nov 10; 539(7628):197-206. PMID: 27830784.
      View in: PubMed
    37. Miyanohara A, Kamizato K, Juhas S, Juhasova J, Navarro M, Marsala S, Lukacova N, Hruska-Plochan M, Curtis E, Gabel B, Ciacci J, Ahrens ET, Kaspar BK, Cleveland D, Marsala M. Potent spinal parenchymal AAV9-mediated gene delivery by subpial injection in adult rats and pigs. Mol Ther Methods Clin Dev. 2016; 3:16046. PMID: 27462649.
      View in: PubMed
    38. Seredenina T, Nayernia Z, Sorce S, Maghzal GJ, Filippova A, Ling SC, Basset O, Plastre O, Daali Y, Rushing EJ, Giordana MT, Cleveland DW, Aguzzi A, Stocker R, Krause KH, Jaquet V. Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis. Free Radic Biol Med. 2016 08; 97:95-108. PMID: 27212019.
      View in: PubMed
    39. Jiang J, Zhu Q, Gendron TF, Saberi S, McAlonis-Downes M, Seelman A, Stauffer JE, Jafar-Nejad P, Drenner K, Schulte D, Chun S, Sun S, Ling SC, Myers B, Engelhardt J, Katz M, Baughn M, Platoshyn O, Marsala M, Watt A, Heyser CJ, Ard MC, De Muynck L, Daughrity LM, Swing DA, Tessarollo L, Jung CJ, Delpoux A, Utzschneider DT, Hedrick SM, de Jong PJ, Edbauer D, Van Damme P, Petrucelli L, Shaw CE, Bennett CF, Da Cruz S, Ravits J, Rigo F, Cleveland DW, Lagier-Tourenne C. Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs. Neuron. 2016 05 04; 90(3):535-50. PMID: 27112497.
      View in: PubMed
    40. Zhang YJ, Gendron TF, Grima JC, Sasaguri H, Jansen-West K, Xu YF, Katzman RB, Gass J, Murray ME, Shinohara M, Lin WL, Garrett A, Stankowski JN, Daughrity L, Tong J, Perkerson EA, Yue M, Chew J, Castanedes-Casey M, Kurti A, Wang ZS, Liesinger AM, Baker JD, Jiang J, Lagier-Tourenne C, Edbauer D, Cleveland DW, Rademakers R, Boylan KB, Bu G, Link CD, Dickey CA, Rothstein JD, Dickson DW, Fryer JD, Petrucelli L. C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins. Nat Neurosci. 2016 05; 19(5):668-677. PMID: 26998601.
      View in: PubMed
    41. Da Cruz S, Cleveland DW. CELL BIOLOGY. Disrupted nuclear import-export in neurodegeneration. Science. 2016 Jan 08; 351(6269):125-6. PMID: 26744395.
      View in: PubMed
    42. Quaegebeur A, Segura I, Schmieder R, Verdegem D, Decimo I, Bifari F, Dresselaers T, Eelen G, Ghosh D, Davidson SM, Schoors S, Broekaert D, Cruys B, Govaerts K, De Legher C, Bouché A, Schoonjans L, Ramer MS, Hung G, Bossaert G, Cleveland DW, Himmelreich U, Voets T, Lemmens R, Bennett CF, Robberecht W, De Bock K, Dewerchin M, Ghesquière B, Fendt SM, Carmeliet P. Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism. Cell Metab. 2016 Feb 09; 23(2):280-91. PMID: 26774962.
      View in: PubMed
    43. Sun S, Sun Y, Ling SC, Ferraiuolo L, McAlonis-Downes M, Zou Y, Drenner K, Wang Y, Ditsworth D, Tokunaga S, Kopelevich A, Kaspar BK, Lagier-Tourenne C, Cleveland DW. Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):E6993-7002. PMID: 26621731.
      View in: PubMed
    44. Rahdar M, McMahon MA, Prakash TP, Swayze EE, Bennett CF, Cleveland DW. Synthetic CRISPR RNA-Cas9-guided genome editing in human cells. Proc Natl Acad Sci U S A. 2015 Dec 22; 112(51):E7110-7. PMID: 26589814.
      View in: PubMed
    45. Kulukian A, Holland AJ, Vitre B, Naik S, Cleveland DW, Fuchs E. Epidermal development, growth control, and homeostasis in the face of centrosome amplification. Proc Natl Acad Sci U S A. 2015 Nov 17; 112(46):E6311-20. PMID: 26578791.
      View in: PubMed
    46. Vitre B, Holland AJ, Kulukian A, Shoshani O, Hirai M, Wang Y, Maldonado M, Cho T, Boubaker J, Swing DA, Tessarollo L, Evans SM, Fuchs E, Cleveland DW. Chronic centrosome amplification without tumorigenesis. Proc Natl Acad Sci U S A. 2015 Nov 17; 112(46):E6321-30. PMID: 26578792.
      View in: PubMed
    47. van Blitterswijk M, Gendron TF, Baker MC, DeJesus-Hernandez M, Finch NA, Brown PH, Daughrity LM, Murray ME, Heckman MG, Jiang J, Lagier-Tourenne C, Edbauer D, Cleveland DW, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Petrucelli L, Boeve BF, Graff-Radford NR, Boylan KB, Dickson DW, Rademakers R. Novel clinical associations with specific C9ORF72 transcripts in patients with repeat expansions in C9ORF72. Acta Neuropathol. 2015 Dec; 130(6):863-76. PMID: 26437865.
      View in: PubMed
    48. Gendron TF, van Blitterswijk M, Bieniek KF, Daughrity LM, Jiang J, Rush BK, Pedraza O, Lucas JA, Murray ME, Desaro P, Robertson A, Overstreet K, Thomas CS, Crook JE, Castanedes-Casey M, Rousseau L, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Boeve BF, Graff-Radford NR, Rademakers R, Lagier-Tourenne C, Edbauer D, Cleveland DW, Dickson DW, Petrucelli L, Boylan KB. Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers. Acta Neuropathol. 2015 Oct; 130(4):559-73. PMID: 26350237.
      View in: PubMed
    49. Topham C, Tighe A, Ly P, Bennett A, Sloss O, Nelson L, Ridgway RA, Huels D, Littler S, Schandl C, Sun Y, Bechi B, Procter DJ, Sansom OJ, Cleveland DW, Taylor SS. MYC Is a Major Determinant of Mitotic Cell Fate. Cancer Cell. 2015 Jul 13; 28(1):129-40. PMID: 26175417.
      View in: PubMed
    50. Mitchell JC, Constable R, So E, Vance C, Scotter E, Glover L, Hortobagyi T, Arnold ES, Ling SC, McAlonis M, Da Cruz S, Polymenidou M, Tessarolo L, Cleveland DW, Shaw CE. Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS. Acta Neuropathol Commun. 2015 Jun 25; 3:36. PMID: 26108367.
      View in: PubMed
    51. Fachinetti D, Han JS, McMahon MA, Ly P, Abdullah A, Wong AJ, Cleveland DW. DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function. Dev Cell. 2015 May 04; 33(3):314-27. PMID: 25942623.
      View in: PubMed
    52. Bertuzzi S, Cleveland DW. The curious incident of the translational dog that didn't bark. Trends Cell Biol. 2015 Apr; 25(4):187-9. PMID: 25817192.
      View in: PubMed
    53. Holland AJ, Reis RM, Niessen S, Pereira C, Andres DA, Spielmann HP, Cleveland DW, Desai A, Gassmann R. Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors. Mol Biol Cell. 2015 May 15; 26(10):1845-56. PMID: 25808490.
      View in: PubMed
    54. Israelson A, Ditsworth D, Sun S, Song S, Liang J, Hruska-Plochan M, McAlonis-Downes M, Abu-Hamad S, Zoltsman G, Shani T, Maldonado M, Bui A, Navarro M, Zhou H, Marsala M, Kaspar BK, Da Cruz S, Cleveland DW. Macrophage migration inhibitory factor as a chaperone inhibiting accumulation of misfolded SOD1. Neuron. 2015 Apr 08; 86(1):218-32. PMID: 25801706.
      View in: PubMed
    55. Sun S, Ling SC, Qiu J, Albuquerque CP, Zhou Y, Tokunaga S, Li H, Qiu H, Bui A, Yeo GW, Huang EJ, Eggan K, Zhou H, Fu XD, Lagier-Tourenne C, Cleveland DW. ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP. Nat Commun. 2015 Jan 27; 6:6171. PMID: 25625564.
      View in: PubMed
    56. Han JS, Vitre B, Fachinetti D, Cleveland DW. Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling. Proc Natl Acad Sci U S A. 2014 Oct 07; 111(40):E4185-93. PMID: 25246557.
      View in: PubMed
    57. Traynor BJ, Cleveland DW. Special Issue on amyotrophic lateral sclerosis. Exp Neurol. 2014 Dec; 262 Pt B:73-4. PMID: 25158310.
      View in: PubMed
    58. Holland AJ, Cleveland DW. Polo-like kinase 4 inhibition: a strategy for cancer therapy? Cancer Cell. 2014 Aug 11; 26(2):151-3. PMID: 25117704.
      View in: PubMed
    59. Bodor DL, Mata JF, Sergeev M, David AF, Salimian KJ, Panchenko T, Cleveland DW, Black BE, Shah JV, Jansen LE. The quantitative architecture of centromeric chromatin. Elife. 2014 Jul 15; 3:e02137. PMID: 25027692.
      View in: PubMed
    60. Vitre B, Gudimchuk N, Borda R, Kim Y, Heuser JE, Cleveland DW, Grishchuk EL. Kinetochore-microtubule attachment throughout mitosis potentiated by the elongated stalk of the kinetochore kinesin CENP-E. Mol Biol Cell. 2014 Aug 01; 25(15):2272-81. PMID: 24920822.
      View in: PubMed
    61. Mirzaa GM, Vitre B, Carpenter G, Abramowicz I, Gleeson JG, Paciorkowski AR, Cleveland DW, Dobyns WB, O'Driscoll M. Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfism. Hum Genet. 2014 Aug; 133(8):1023-39. PMID: 24748105.
      View in: PubMed
    62. Cortes CJ, Ling SC, Guo LT, Hung G, Tsunemi T, Ly L, Tokunaga S, Lopez E, Sopher BL, Bennett CF, Shelton GD, Cleveland DW, La Spada AR. Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophy. Neuron. 2014 Apr 16; 82(2):295-307. PMID: 24742458.
      View in: PubMed
    63. Winkler EA, Sengillo JD, Sagare AP, Zhao Z, Ma Q, Zuniga E, Wang Y, Zhong Z, Sullivan JS, Griffin JH, Cleveland DW, Zlokovic BV. Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):E1035-42. PMID: 24591593.
      View in: PubMed
    64. Crotti A, Benner C, Kerman BE, Gosselin D, Lagier-Tourenne C, Zuccato C, Cattaneo E, Gage FH, Cleveland DW, Glass CK. Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors. Nat Neurosci. 2014 Apr; 17(4):513-21. PMID: 24584051.
      View in: PubMed
    65. Lobsiger CS, Cleveland DW. Reply to Woodruff et al.: C1q and C3-dependent complement pathway activation does not contribute to disease in SOD1 mutant ALS mice. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):E5. PMID: 24555201.
      View in: PubMed
    66. Meyer K, Ferraiuolo L, Miranda CJ, Likhite S, McElroy S, Renusch S, Ditsworth D, Lagier-Tourenne C, Smith RA, Ravits J, Burghes AH, Shaw PJ, Cleveland DW, Kolb SJ, Kaspar BK. Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS. Proc Natl Acad Sci U S A. 2014 Jan 14; 111(2):829-32. PMID: 24379375.
      View in: PubMed
    67. Parone PA, Da Cruz S, Cleveland DW. Mitochondrial Isolation and Purification from Mouse Spinal Cord. Bio Protoc. 2013 Nov 05; 3(21). PMID: 27819013.
      View in: PubMed
    68. Lobsiger CS, Boillée S, Pozniak C, Khan AM, McAlonis-Downes M, Lewcock JW, Cleveland DW. C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice. Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46):E4385-92. PMID: 24170856.
      View in: PubMed
    69. Lagier-Tourenne C, Baughn M, Rigo F, Sun S, Liu P, Li HR, Jiang J, Watt AT, Chun S, Katz M, Qiu J, Sun Y, Ling SC, Zhu Q, Polymenidou M, Drenner K, Artates JW, McAlonis-Downes M, Markmiller S, Hutt KR, Pizzo DP, Cady J, Harms MB, Baloh RH, Vandenberg SR, Yeo GW, Fu XD, Bennett CF, Cleveland DW, Ravits J. Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4530-9. PMID: 24170860.
      View in: PubMed
    70. Silk AD, Zasadil LM, Holland AJ, Vitre B, Cleveland DW, Weaver BA. Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):E4134-41. PMID: 24133140.
      View in: PubMed
    71. Foust KD, Salazar DL, Likhite S, Ferraiuolo L, Ditsworth D, Ilieva H, Meyer K, Schmelzer L, Braun L, Cleveland DW, Kaspar BK. Therapeutic AAV9-mediated suppression of mutant SOD1 slows disease progression and extends survival in models of inherited ALS. Mol Ther. 2013 Dec; 21(12):2148-59. PMID: 24008656.
      View in: PubMed
    72. Gudimchuk N, Vitre B, Kim Y, Kiyatkin A, Cleveland DW, Ataullakhanov FI, Grishchuk EL. Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips. Nat Cell Biol. 2013 Sep; 15(9):1079-1088. PMID: 23955301.
      View in: PubMed
    73. Ling SC, Polymenidou M, Cleveland DW. Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis. Neuron. 2013 Aug 07; 79(3):416-38. PMID: 23931993.
      View in: PubMed
    74. Earnshaw WC, Cleveland DW. CENP-A and the CENP nomenclature: response to Talbert and Henikoff. Trends Genet. 2013 Sep; 29(9):500-2. PMID: 23910159.
      View in: PubMed
    75. Fachinetti D, Folco HD, Nechemia-Arbely Y, Valente LP, Nguyen K, Wong AJ, Zhu Q, Holland AJ, Desai A, Jansen LE, Cleveland DW. A two-step mechanism for epigenetic specification of centromere identity and function. Nat Cell Biol. 2013 Sep; 15(9):1056-66. PMID: 23873148.
      View in: PubMed
    76. Han JS, Holland AJ, Fachinetti D, Kulukian A, Cetin B, Cleveland DW. Catalytic assembly of the mitotic checkpoint inhibitor BubR1-Cdc20 by a Mad2-induced functional switch in Cdc20. Mol Cell. 2013 Jul 11; 51(1):92-104. PMID: 23791783.
      View in: PubMed
    77. Earnshaw WC, Allshire RC, Black BE, Bloom K, Brinkley BR, Brown W, Cheeseman IM, Choo KH, Copenhaver GP, Deluca JG, Desai A, Diekmann S, Erhardt S, Fitzgerald-Hayes M, Foltz D, Fukagawa T, Gassmann R, Gerlich DW, Glover DM, Gorbsky GJ, Harrison SC, Heun P, Hirota T, Jansen LE, Karpen G, Kops GJ, Lampson MA, Lens SM, Losada A, Luger K, Maiato H, Maddox PS, Margolis RL, Masumoto H, McAinsh AD, Mellone BG, Meraldi P, Musacchio A, Oegema K, O'Neill RJ, Salmon ED, Scott KC, Straight AF, Stukenberg PT, Sullivan BA, Sullivan KF, Sunkel CE, Swedlow JR, Walczak CE, Warburton PE, Westermann S, Willard HF, Wordeman L, Yanagida M, Yen TJ, Yoda K, Cleveland DW. Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Res. 2013 Apr; 21(2):101-6. PMID: 23580138.
      View in: PubMed
    78. Kang SH, Li Y, Fukaya M, Lorenzini I, Cleveland DW, Ostrow LW, Rothstein JD, Bergles DE. Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. Nat Neurosci. 2013 May; 16(5):571-9. PMID: 23542689.
      View in: PubMed
    79. Parone PA, Da Cruz S, Han JS, McAlonis-Downes M, Vetto AP, Lee SK, Tseng E, Cleveland DW. Enhancing mitochondrial calcium buffering capacity reduces aggregation of misfolded SOD1 and motor neuron cell death without extending survival in mouse models of inherited amyotrophic lateral sclerosis. J Neurosci. 2013 Mar 13; 33(11):4657-71. PMID: 23486940.
      View in: PubMed
    80. Arnold ES, Ling SC, Huelga SC, Lagier-Tourenne C, Polymenidou M, Ditsworth D, Kordasiewicz HB, McAlonis-Downes M, Platoshyn O, Parone PA, Da Cruz S, Clutario KM, Swing D, Tessarollo L, Marsala M, Shaw CE, Yeo GW, Cleveland DW. ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):E736-45. PMID: 23382207.
      View in: PubMed
    81. Holland AJ, Fachinetti D, Zhu Q, Bauer M, Verma IM, Nigg EA, Cleveland DW. The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle. Genes Dev. 2012 Dec 15; 26(24):2684-9. PMID: 23249732.
      View in: PubMed
    82. Sun S, Cleveland DW. TDP-43 toxicity and the usefulness of junk. Nat Genet. 2012 Dec; 44(12):1289-91. PMID: 23192178.
      View in: PubMed
    83. Holland AJ, Cleveland DW. The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation. J Clin Invest. 2012 Dec; 122(12):4325-8. PMID: 23187131.
      View in: PubMed
    84. Holland AJ, Fachinetti D, Han JS, Cleveland DW. Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cells. Proc Natl Acad Sci U S A. 2012 Dec 04; 109(49):E3350-7. PMID: 23150568.
      View in: PubMed
    85. Holland AJ, Cleveland DW. Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements. Nat Med. 2012 Nov; 18(11):1630-8. PMID: 23135524.
      View in: PubMed
    86. Vitre BD, Cleveland DW. Centrosomes, chromosome instability (CIN) and aneuploidy. Curr Opin Cell Biol. 2012 Dec; 24(6):809-15. PMID: 23127609.
      View in: PubMed
    87. Lagier-Tourenne C, Polymenidou M, Hutt KR, Vu AQ, Baughn M, Huelga SC, Clutario KM, Ling SC, Liang TY, Mazur C, Wancewicz E, Kim AS, Watt A, Freier S, Hicks GG, Donohue JP, Shiue L, Bennett CF, Ravits J, Cleveland DW, Yeo GW. Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. Nat Neurosci. 2012 Nov; 15(11):1488-97. PMID: 23023293.
      View in: PubMed
    88. Yu D, Pendergraff H, Liu J, Kordasiewicz HB, Cleveland DW, Swayze EE, Lima WF, Crooke ST, Prakash TP, Corey DR. Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression. Cell. 2012 Aug 31; 150(5):895-908. PMID: 22939619.
      View in: PubMed
    89. Hefferan MP, Galik J, Kakinohana O, Sekerkova G, Santucci C, Marsala S, Navarro R, Hruska-Plochan M, Johe K, Feldman E, Cleveland DW, Marsala M. Human neural stem cell replacement therapy for amyotrophic lateral sclerosis by spinal transplantation. PLoS One. 2012; 7(8):e42614. PMID: 22916141.
      View in: PubMed
    90. Kordasiewicz HB, Stanek LM, Wancewicz EV, Mazur C, McAlonis MM, Pytel KA, Artates JW, Weiss A, Cheng SH, Shihabuddin LS, Hung G, Bennett CF, Cleveland DW. Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis. Neuron. 2012 Jun 21; 74(6):1031-44. PMID: 22726834.
      View in: PubMed
    91. Holland AJ, Cleveland DW. Losing balance: the origin and impact of aneuploidy in cancer. EMBO Rep. 2012 Jun 01; 13(6):501-14. PMID: 22565320.
      View in: PubMed
    92. Polymenidou M, Cleveland DW. Prion-like spread of protein aggregates in neurodegeneration. J Exp Med. 2012 May 07; 209(5):889-93. PMID: 22566400.
      View in: PubMed
    93. Kolano A, Brunet S, Silk AD, Cleveland DW, Verlhac MH. Error-prone mammalian female meiosis from silencing the spindle assembly checkpoint without normal interkinetochore tension. Proc Natl Acad Sci U S A. 2012 Jul 03; 109(27):E1858-67. PMID: 22552228.
      View in: PubMed
    94. Da Cruz S, Parone PA, Lopes VS, Lillo C, McAlonis-Downes M, Lee SK, Vetto AP, Petrosyan S, Marsala M, Murphy AN, Williams DS, Spiegelman BM, Cleveland DW. Elevated PGC-1a activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS. Cell Metab. 2012 May 02; 15(5):778-86. PMID: 22560226.
      View in: PubMed
    95. Nechemia-Arbely Y, Fachinetti D, Cleveland DW. Replicating centromeric chromatin: spatial and temporal control of CENP-A assembly. Exp Cell Res. 2012 Jul 15; 318(12):1353-60. PMID: 22561213.
      View in: PubMed
    96. Holland AJ, Fachinetti D, Da Cruz S, Zhu Q, Vitre B, Lince-Faria M, Chen D, Parish N, Verma IM, Bettencourt-Dias M, Cleveland DW. Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis. Mol Biol Cell. 2012 May; 23(10):1838-45. PMID: 22456511.
      View in: PubMed
    97. Polymenidou M, Lagier-Tourenne C, Hutt KR, Bennett CF, Cleveland DW, Yeo GW. Misregulated RNA processing in amyotrophic lateral sclerosis. Brain Res. 2012 Jun 26; 1462:3-15. PMID: 22444279.
      View in: PubMed
    98. Polymenidou M, Cleveland DW. The seeds of neurodegeneration: prion-like spreading in ALS. Cell. 2011 Oct 28; 147(3):498-508. PMID: 22036560.
      View in: PubMed
    99. Kolodner RD, Cleveland DW, Putnam CD. Cancer. Aneuploidy drives a mutator phenotype in cancer. Science. 2011 Aug 19; 333(6045):942-3. PMID: 21852477.
      View in: PubMed
    100. Da Cruz S, Cleveland DW. Understanding the role of TDP-43 and FUS/TLS in ALS and beyond. Curr Opin Neurobiol. 2011 Dec; 21(6):904-19. PMID: 21813273.
      View in: PubMed
    101. Vande Velde C, McDonald KK, Boukhedimi Y, McAlonis-Downes M, Lobsiger CS, Bel Hadj S, Zandona A, Julien JP, Shah SB, Cleveland DW. Misfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset. PLoS One. 2011; 6(7):e22031. PMID: 21779368.
      View in: PubMed
    102. Black BE, Jansen LE, Foltz DR, Cleveland DW. Centromere identity, function, and epigenetic propagation across cell divisions. Cold Spring Harb Symp Quant Biol. 2010; 75:403-18. PMID: 21467140.
      View in: PubMed
    103. Polymenidou M, Lagier-Tourenne C, Hutt KR, Huelga SC, Moran J, Liang TY, Ling SC, Sun E, Wancewicz E, Mazur C, Kordasiewicz H, Sedaghat Y, Donohue JP, Shiue L, Bennett CF, Yeo GW, Cleveland DW. Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. Nat Neurosci. 2011 Apr; 14(4):459-68. PMID: 21358643.
      View in: PubMed
    104. Black BE, Cleveland DW. Epigenetic centromere propagation and the nature of CENP-a nucleosomes. Cell. 2011 Feb 18; 144(4):471-9. PMID: 21335232.
      View in: PubMed
    105. Li Q, Vande Velde C, Israelson A, Xie J, Bailey AO, Dong MQ, Chun SJ, Roy T, Winer L, Yates JR, Capaldi RA, Cleveland DW, Miller TM. ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import. Proc Natl Acad Sci U S A. 2010 Dec 07; 107(49):21146-51. PMID: 21078990.
      View in: PubMed
    106. Hatch EM, Kulukian A, Holland AJ, Cleveland DW, Stearns T. Cep152 interacts with Plk4 and is required for centriole duplication. J Cell Biol. 2010 Nov 15; 191(4):721-9. PMID: 21059850.
      View in: PubMed
    107. Cetin B, Cleveland DW. How to survive aneuploidy. Cell. 2010 Oct 01; 143(1):27-9. PMID: 20887888.
      View in: PubMed
    108. Lan W, Cleveland DW. Multiclassifier proteomics to define complexes yields new chromosomal proteins. Dev Cell. 2010 Sep 14; 19(3):356-9. PMID: 20833356.
      View in: PubMed
    109. Israelson A, Arbel N, Da Cruz S, Ilieva H, Yamanaka K, Shoshan-Barmatz V, Cleveland DW. Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS. Neuron. 2010 Aug 26; 67(4):575-87. PMID: 20797535.
      View in: PubMed
    110. Lagier-Tourenne C, Cleveland DW. Neurodegeneration: An expansion in ALS genetics. Nature. 2010 Aug 26; 466(7310):1052-3. PMID: 20740002.
      View in: PubMed
    111. Kim Y, Holland AJ, Lan W, Cleveland DW. Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E. Cell. 2010 Aug 06; 142(3):444-55. PMID: 20691903.
      View in: PubMed
    112. Holland AJ, Lan W, Cleveland DW. Centriole duplication: A lesson in self-control. Cell Cycle. 2010 Jul 15; 9(14):2731-6. PMID: 20647763.
      View in: PubMed
    113. Lan W, Cleveland DW. A chemical tool box defines mitotic and interphase roles for Mps1 kinase. J Cell Biol. 2010 Jul 12; 190(1):21-4. PMID: 20624898.
      View in: PubMed
    114. Ling SC, Albuquerque CP, Han JS, Lagier-Tourenne C, Tokunaga S, Zhou H, Cleveland DW. ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS. Proc Natl Acad Sci U S A. 2010 Jul 27; 107(30):13318-23. PMID: 20624952.
      View in: PubMed
    115. Gassmann R, Holland AJ, Varma D, Wan X, Civril F, Cleveland DW, Oegema K, Salmon ED, Desai A. Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells. Genes Dev. 2010 May; 24(9):957-71. PMID: 20439434.
      View in: PubMed
    116. Lagier-Tourenne C, Polymenidou M, Cleveland DW. TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration. Hum Mol Genet. 2010 Apr 15; 19(R1):R46-64. PMID: 20400460.
      View in: PubMed
    117. Radulescu AE, Cleveland DW. NuMA after 30 years: the matrix revisited. Trends Cell Biol. 2010 Apr; 20(4):214-22. PMID: 20137953.
      View in: PubMed
    118. Holland AJ, Lan W, Niessen S, Hoover H, Cleveland DW. Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability. J Cell Biol. 2010 Jan 25; 188(2):191-8. PMID: 20100909.
      View in: PubMed
    119. Gurden MD, Holland AJ, van Zon W, Tighe A, Vergnolle MA, Andres DA, Spielmann HP, Malumbres M, Wolthuis RM, Cleveland DW, Taylor SS. Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F. J Cell Sci. 2010 Feb 01; 123(Pt 3):321-30. PMID: 20053638.
      View in: PubMed
    120. Ilieva H, Polymenidou M, Cleveland DW. Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. J Cell Biol. 2009 Dec 14; 187(6):761-72. PMID: 19951898.
      View in: PubMed
    121. Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino FJ, Stojanovic K, Cleveland DW, Zlokovic BV. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J Clin Invest. 2009 Nov; 119(11):3437-49. PMID: 19841542.
      View in: PubMed
    122. Zeitlin SG, Baker NM, Chapados BR, Soutoglou E, Wang JY, Berns MW, Cleveland DW. Double-strand DNA breaks recruit the centromeric histone CENP-A. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):15762-7. PMID: 19717431.
      View in: PubMed
    123. Samoshkin A, Arnaoutov A, Jansen LE, Ouspenski I, Dye L, Karpova T, McNally J, Dasso M, Cleveland DW, Strunnikov A. Human condensin function is essential for centromeric chromatin assembly and proper sister kinetochore orientation. PLoS One. 2009 Aug 28; 4(8):e6831. PMID: 19714251.
      View in: PubMed
    124. Holland AJ, Cleveland DW. Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol. 2009 Jul; 10(7):478-87. PMID: 19546858.
      View in: PubMed
    125. Weaver BA, Cleveland DW. The role of aneuploidy in promoting and suppressing tumors. J Cell Biol. 2009 Jun 15; 185(6):935-7. PMID: 19528293.
      View in: PubMed
    126. Foltz DR, Jansen LE, Bailey AO, Yates JR, Bassett EA, Wood S, Black BE, Cleveland DW. Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP. Cell. 2009 May 01; 137(3):472-84. PMID: 19410544.
      View in: PubMed
    127. Lagier-Tourenne C, Cleveland DW. Rethinking ALS: the FUS about TDP-43. Cell. 2009 Mar 20; 136(6):1001-4. PMID: 19303844.
      View in: PubMed
    128. Silk AD, Holland AJ, Cleveland DW. Requirements for NuMA in maintenance and establishment of mammalian spindle poles. J Cell Biol. 2009 Mar 09; 184(5):677-90. PMID: 19255246.
      View in: PubMed
    129. Lobsiger CS, Boillee S, McAlonis-Downes M, Khan AM, Feltri ML, Yamanaka K, Cleveland DW. Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4465-70. PMID: 19251638.
      View in: PubMed
    130. Garcia ML, Rao MV, Fujimoto J, Garcia VB, Shah SB, Crum J, Gotow T, Uchiyama Y, Ellisman M, Calcutt NA, Cleveland DW. Phosphorylation of highly conserved neurofilament medium KSP repeats is not required for myelin-dependent radial axonal growth. J Neurosci. 2009 Feb 04; 29(5):1277-84. PMID: 19193875.
      View in: PubMed
    131. Cleveland DW, Yamanaka K, Bomont P. Gigaxonin controls vimentin organization through a tubulin chaperone-independent pathway. Hum Mol Genet. 2009 Apr 15; 18(8):1384-94. PMID: 19168853.
      View in: PubMed
    132. Kulukian A, Han JS, Cleveland DW. Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding. Dev Cell. 2009 Jan; 16(1):105-17. PMID: 19154722.
      View in: PubMed
    133. Weaver BA, Cleveland DW. The aneuploidy paradox in cell growth and tumorigenesis. Cancer Cell. 2008 Dec 09; 14(6):431-3. PMID: 19061834.
      View in: PubMed
    134. Ilieva HS, Yamanaka K, Malkmus S, Kakinohana O, Yaksh T, Marsala M, Cleveland DW. Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12599-604. PMID: 18719118.
      View in: PubMed
    135. Holland AJ, Cleveland DW. Beyond genetics: surprising determinants of cell fate in antitumor drugs. Cancer Cell. 2008 Aug 12; 14(2):103-5. PMID: 18691543.
      View in: PubMed
    136. Chang Y, Kong Q, Shan X, Tian G, Ilieva H, Cleveland DW, Rothstein JD, Borchelt DR, Wong PC, Lin CL. Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS. PLoS One. 2008 Aug 06; 3(8):e2849. PMID: 18682740.
      View in: PubMed
    137. Dequen F, Bomont P, Gowing G, Cleveland DW, Julien JP. Modest loss of peripheral axons, muscle atrophy and formation of brain inclusions in mice with targeted deletion of gigaxonin exon 1. J Neurochem. 2008 Oct; 107(1):253-64. PMID: 18680552.
      View in: PubMed
    138. Polymenidou M, Cleveland DW. Motor neuron disease: The curious ways of ALS. Nature. 2008 Jul 17; 454(7202):284-5. PMID: 18633404.
      View in: PubMed
    139. Jelluma N, Brenkman AB, McLeod I, Yates JR, Cleveland DW, Medema RH, Kops GJ. Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes. PLoS One. 2008 Jun 11; 3(6):e2415. PMID: 18545697.
      View in: PubMed
    140. Yamanaka K, Boillee S, Roberts EA, Garcia ML, McAlonis-Downes M, Mikse OR, Cleveland DW, Goldstein LS. Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7594-9. PMID: 18492803.
      View in: PubMed
    141. Kim Y, Heuser JE, Waterman CM, Cleveland DW. CENP-E combines a slow, processive motor and a flexible coiled coil to produce an essential motile kinetochore tether. J Cell Biol. 2008 May 05; 181(3):411-9. PMID: 18443223.
      View in: PubMed
    142. Zhong Z, Deane R, Ali Z, Parisi M, Shapovalov Y, O'Banion MK, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV. ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat Neurosci. 2008 Apr; 11(4):420-2. PMID: 18344992.
      View in: PubMed
    143. Vande Velde C, Miller TM, Cashman NR, Cleveland DW. Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):4022-7. PMID: 18296640.
      View in: PubMed
    144. Yamanaka K, Chun SJ, Boillee S, Fujimori-Tonou N, Yamashita H, Gutmann DH, Takahashi R, Misawa H, Cleveland DW. Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat Neurosci. 2008 Mar; 11(3):251-3. PMID: 18246065.
      View in: PubMed
    145. Boillée S, Cleveland DW. Revisiting oxidative damage in ALS: microglia, Nox, and mutant SOD1. J Clin Invest. 2008 Feb; 118(2):474-8. PMID: 18219386.
      View in: PubMed
    146. Weaver BA, Silk AD, Cleveland DW. Low rates of aneuploidy promote tumorigenesis while high rates of aneuploidy cause cell death and tumor suppression. Cell Oncol. 2008; 30(5):453. PMID: 18791276.
      View in: PubMed
    147. Weaver BA, Cleveland DW. Aneuploidy: instigator and inhibitor of tumorigenesis. Cancer Res. 2007 Nov 01; 67(21):10103-5. PMID: 17974949.
      View in: PubMed
    148. Lobsiger CS, Cleveland DW. Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease. Nat Neurosci. 2007 Nov; 10(11):1355-60. PMID: 17965655.
      View in: PubMed
    149. Detmer SA, Vande Velde C, Cleveland DW, Chan DC. Hindlimb gait defects due to motor axon loss and reduced distal muscles in a transgenic mouse model of Charcot-Marie-Tooth type 2A. Hum Mol Genet. 2008 Feb 01; 17(3):367-75. PMID: 17959936.
      View in: PubMed
    150. Gruzman A, Wood WL, Alpert E, Prasad MD, Miller RG, Rothstein JD, Bowser R, Hamilton R, Wood TD, Cleveland DW, Lingappa VR, Liu J. Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2007 Jul 24; 104(30):12524-9. PMID: 17636119.
      View in: PubMed
    151. Bailey AO, Miller TM, Dong MQ, Vande Velde C, Cleveland DW, Yates JR. RCADiA: simple automation platform for comparative multidimensional protein identification technology. Anal Chem. 2007 Aug 15; 79(16):6410-8. PMID: 17616168.
      View in: PubMed
    152. Weaver BA, Cleveland DW. Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint". Science. 2007 May 18; 316(5827):982; author reply 982. PMID: 17510348.
      View in: PubMed
    153. Rakhit R, Robertson J, Vande Velde C, Horne P, Ruth DM, Griffin J, Cleveland DW, Cashman NR, Chakrabartty A. An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS. Nat Med. 2007 Jun; 13(6):754-9. PMID: 17486090.
      View in: PubMed
    154. Conde e Silva N, Black BE, Sivolob A, Filipski J, Cleveland DW, Prunell A. CENP-A-containing nucleosomes: easier disassembly versus exclusive centromeric localization. J Mol Biol. 2007 Jul 13; 370(3):555-73. PMID: 17524417.
      View in: PubMed
    155. Lobsiger CS, Boillée S, Cleveland DW. Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons. Proc Natl Acad Sci U S A. 2007 May 01; 104(18):7319-26. PMID: 17463094.
      View in: PubMed
    156. Black BE, Brock MA, Bédard S, Woods VL, Cleveland DW. An epigenetic mark generated by the incorporation of CENP-A into centromeric nucleosomes. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):5008-13. PMID: 17360341.
      View in: PubMed
    157. Jansen LE, Black BE, Foltz DR, Cleveland DW. Propagation of centromeric chromatin requires exit from mitosis. J Cell Biol. 2007 Mar 12; 176(6):795-805. PMID: 17339380.
      View in: PubMed
    158. Black BE, Jansen LE, Maddox PS, Foltz DR, Desai AB, Shah JV, Cleveland DW. Centromere identity maintained by nucleosomes assembled with histone H3 containing the CENP-A targeting domain. Mol Cell. 2007 Jan 26; 25(2):309-22. PMID: 17244537.
      View in: PubMed
    159. Weaver BA, Silk AD, Montagna C, Verdier-Pinard P, Cleveland DW. Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell. 2007 Jan; 11(1):25-36. PMID: 17189716.
      View in: PubMed
    160. Miller TM, Kim SH, Yamanaka K, Hester M, Umapathi P, Arnson H, Rizo L, Mendell JR, Gage FH, Cleveland DW, Kaspar BK. Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51):19546-51. PMID: 17164329.
      View in: PubMed
    161. Weaver BA, Cleveland DW. Does aneuploidy cause cancer? Curr Opin Cell Biol. 2006 Dec; 18(6):658-67. PMID: 17046232.
      View in: PubMed
    162. Boillée S, Vande Velde C, Cleveland DW. ALS: a disease of motor neurons and their nonneuronal neighbors. Neuron. 2006 Oct 05; 52(1):39-59. PMID: 17015226.
      View in: PubMed
    163. Ross CA, Cleveland DW. Intercellular miscommunication in polyglutamine pathogenesis. Nat Neurosci. 2006 Oct; 9(10):1205-6. PMID: 17001335.
      View in: PubMed
    164. Miller TM, Smith RA, Cleveland DW. Amyotrophic lateral sclerosis and gene therapy. Nat Clin Pract Neurol. 2006 Sep; 2(9):462-3. PMID: 16932606.
      View in: PubMed
    165. Weaver BA, Silk AD, Cleveland DW. Cell biology: nondisjunction, aneuploidy and tetraploidy. Nature. 2006 Aug 17; 442(7104):E9-10; discussion E10. PMID: 16915240.
      View in: PubMed
    166. Smith RA, Miller TM, Yamanaka K, Monia BP, Condon TP, Hung G, Lobsiger CS, Ward CM, McAlonis-Downes M, Wei H, Wancewicz EV, Bennett CF, Cleveland DW. Antisense oligonucleotide therapy for neurodegenerative disease. J Clin Invest. 2006 Aug; 116(8):2290-6. PMID: 16878173.
      View in: PubMed
    167. Yamanaka K, Miller TM, McAlonis-Downes M, Chun SJ, Cleveland DW. Progressive spinal axonal degeneration and slowness in ALS2-deficient mice. Ann Neurol. 2006 Jul; 60(1):95-104. PMID: 16802286.
      View in: PubMed
    168. Dhib-Jalbut S, Arnold DL, Cleveland DW, Fisher M, Friedlander RM, Mouradian MM, Przedborski S, Trapp BD, Wyss-Coray T, Yong VW. Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases. J Neuroimmunol. 2006 Jul; 176(1-2):198-215. PMID: 16983747.
      View in: PubMed
    169. Boillée S, Yamanaka K, Lobsiger CS, Copeland NG, Jenkins NA, Kassiotis G, Kollias G, Cleveland DW. Onset and progression in inherited ALS determined by motor neurons and microglia. Science. 2006 Jun 02; 312(5778):1389-92. PMID: 16741123.
      View in: PubMed
    170. Eymard-Pierre E, Yamanaka K, Haeussler M, Kress W, Gauthier-Barichard F, Combes P, Cleveland DW, Boespflug-Tanguy O. Novel missense mutation in ALS2 gene results in infantile ascending hereditary spastic paralysis. Ann Neurol. 2006 Jun; 59(6):976-80. PMID: 16718699.
      View in: PubMed
    171. Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW. The human CENP-A centromeric nucleosome-associated complex. Nat Cell Biol. 2006 May; 8(5):458-69. PMID: 16622419.
      View in: PubMed
    172. Wang Z, Shah JV, Berns MW, Cleveland DW. In vivo quantitative studies of dynamic intracellular processes using fluorescence correlation spectroscopy. Biophys J. 2006 Jul 01; 91(1):343-51. PMID: 16603490.
      View in: PubMed
    173. Yamanaka K, Cleveland DW. Determinants of rapid disease progression in ALS. Neurology. 2005 Dec 27; 65(12):1859-60. PMID: 16380607.
      View in: PubMed
    174. Bomont P, Maddox P, Shah JV, Desai AB, Cleveland DW. Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F. EMBO J. 2005 Nov 16; 24(22):3927-39. PMID: 16252009.
      View in: PubMed
    175. Kops GJ, Weaver BA, Cleveland DW. On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer. 2005 Oct; 5(10):773-85. PMID: 16195750.
      View in: PubMed
    176. Mao Y, Desai A, Cleveland DW. Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling. J Cell Biol. 2005 Sep 12; 170(6):873-80. PMID: 16144904.
      View in: PubMed
    177. Garcia ML, Singleton AB, Hernandez D, Ward CM, Evey C, Sapp PA, Hardy J, Brown RH, Cleveland DW. Mutations in neurofilament genes are not a significant primary cause of non-SOD1-mediated amyotrophic lateral sclerosis. Neurobiol Dis. 2006 Jan; 21(1):102-9. PMID: 16084104.
      View in: PubMed
    178. Lobsiger CS, Garcia ML, Ward CM, Cleveland DW. Altered axonal architecture by removal of the heavily phosphorylated neurofilament tail domains strongly slows superoxide dismutase 1 mutant-mediated ALS. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10351-6. PMID: 16002469.
      View in: PubMed
    179. Weaver BA, Cleveland DW. Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death. Cancer Cell. 2005 Jul; 8(1):7-12. PMID: 16023594.
      View in: PubMed
    180. Liu J, Shinobu LA, Ward CM, Young D, Cleveland DW. Elevation of the Hsp70 chaperone does not effect toxicity in mouse models of familial amyotrophic lateral sclerosis. J Neurochem. 2005 May; 93(4):875-82. PMID: 15857390.
      View in: PubMed
    181. Miller TM, Kaspar BK, Kops GJ, Yamanaka K, Christian LJ, Gage FH, Cleveland DW. Virus-delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis. Ann Neurol. 2005 May; 57(5):773-6. PMID: 15852369.
      View in: PubMed
    182. Beghi E, Bendotti C, Mennini T, Miller T, Cleveland D. Merits of a New Drug Trial for ALS? Science. 2005 Apr 29; 308(5722):632b-633b. PMID: 15863397.
      View in: PubMed
    183. Kops GJ, Kim Y, Weaver BA, Mao Y, McLeod I, Yates JR, Tagaya M, Cleveland DW. ZW10 links mitotic checkpoint signaling to the structural kinetochore. J Cell Biol. 2005 Apr 11; 169(1):49-60. PMID: 15824131.
      View in: PubMed
    184. Miller TM, Cleveland DW. Medicine. Treating neurodegenerative diseases with antibiotics. Science. 2005 Jan 21; 307(5708):361-2. PMID: 15661995.
      View in: PubMed
    185. Vande Velde C, Cleveland DW. VEGF: multitasking in ALS. Nat Neurosci. 2005 Jan; 8(1):5-7. PMID: 15622408.
      View in: PubMed
    186. Wang H, Hu X, Ding X, Dou Z, Yang Z, Shaw AW, Teng M, Cleveland DW, Goldberg ML, Niu L, Yao X. Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling. J Biol Chem. 2004 Dec 24; 279(52):54590-8. PMID: 15485811.
      View in: PubMed
    187. Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L. A standardized kinesin nomenclature. J Cell Biol. 2004 Oct 11; 167(1):19-22. PMID: 15479732.
      View in: PubMed
    188. Black BE, Foltz DR, Chakravarthy S, Luger K, Woods VL, Cleveland DW. Structural determinants for generating centromeric chromatin. Nature. 2004 Jul 29; 430(6999):578-82. PMID: 15282608.
      View in: PubMed
    189. Liu J, Lillo C, Jonsson PA, Vande Velde C, Ward CM, Miller TM, Subramaniam JR, Rothstein JD, Marklund S, Andersen PM, Brännström T, Gredal O, Wong PC, Williams DS, Cleveland DW. Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria. Neuron. 2004 Jul 08; 43(1):5-17. PMID: 15233913.
      View in: PubMed
    190. Shah JV, Botvinick E, Bonday Z, Furnari F, Berns M, Cleveland DW. Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing. Curr Biol. 2004 Jun 08; 14(11):942-52. PMID: 15182667.
      View in: PubMed
    191. Kops GJ, Foltz DR, Cleveland DW. Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint. Proc Natl Acad Sci U S A. 2004 Jun 08; 101(23):8699-704. PMID: 15159543.
      View in: PubMed
    192. Boillée S, Cleveland DW. Gene therapy for ALS delivers. Trends Neurosci. 2004 May; 27(5):235-8. PMID: 15111001.
      View in: PubMed
    193. Bruijn LI, Miller TM, Cleveland DW. Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu Rev Neurosci. 2004; 27:723-49. PMID: 15217349.
      View in: PubMed
    194. Vande Velde C, Garcia ML, Yin X, Trapp BD, Cleveland DW. The neuroprotective factor Wlds does not attenuate mutant SOD1-mediated motor neuron disease. Neuromolecular Med. 2004; 5(3):193-203. PMID: 15626820.
      View in: PubMed
    195. Yamanaka K, Vande Velde C, Eymard-Pierre E, Bertini E, Boespflug-Tanguy O, Cleveland DW. Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):16041-6. PMID: 14668431.
      View in: PubMed
    196. Garcia ML, Lobsiger CS, Shah SB, Deerinck TJ, Crum J, Young D, Ward CM, Crawford TO, Gotow T, Uchiyama Y, Ellisman MH, Calcutt NA, Cleveland DW. NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growth. J Cell Biol. 2003 Dec 08; 163(5):1011-20. PMID: 14662745.
      View in: PubMed
    197. Clement AM, Nguyen MD, Roberts EA, Garcia ML, Boillée S, Rule M, McMahon AP, Doucette W, Siwek D, Ferrante RJ, Brown RH, Julien JP, Goldstein LS, Cleveland DW. Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science. 2003 Oct 03; 302(5642):113-7. PMID: 14526083.
      View in: PubMed
    198. Miller TM, Cleveland DW. Has gene therapy for ALS arrived? Nat Med. 2003 Oct; 9(10):1256-7. PMID: 14520369.
      View in: PubMed
    199. Weaver BA, Bonday ZQ, Putkey FR, Kops GJ, Silk AD, Cleveland DW. Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss. J Cell Biol. 2003 Aug 18; 162(4):551-63. PMID: 12925705.
      View in: PubMed
    200. Mao Y, Abrieu A, Cleveland DW. Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1. Cell. 2003 Jul 11; 114(1):87-98. PMID: 12859900.
      View in: PubMed
    201. Xia CH, Roberts EA, Her LS, Liu X, Williams DS, Cleveland DW, Goldstein LS. Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A. J Cell Biol. 2003 Apr 14; 161(1):55-66. PMID: 12682084.
      View in: PubMed
    202. Cleveland DW, Mao Y, Sullivan KF. Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell. 2003 Feb 21; 112(4):407-21. PMID: 12600307.
      View in: PubMed
    203. Raoul C, Estévez AG, Nishimune H, Cleveland DW, deLapeyrière O, Henderson CE, Haase G, Pettmann B. Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations. Neuron. 2002 Sep 12; 35(6):1067-83. PMID: 12354397.
      View in: PubMed
    204. Putkey FR, Cramer T, Morphew MK, Silk AD, Johnson RS, McIntosh JR, Cleveland DW. Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E. Dev Cell. 2002 Sep; 3(3):351-65. PMID: 12361599.
      View in: PubMed
    205. Rao MV, Garcia ML, Miyazaki Y, Gotow T, Yuan A, Mattina S, Ward CM, Calcutt NA, Uchiyama Y, Nixon RA, Cleveland DW. Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport. J Cell Biol. 2002 Aug 19; 158(4):681-93. PMID: 12186852.
      View in: PubMed
    206. Subramaniam JR, Lyons WE, Liu J, Bartnikas TB, Rothstein J, Price DL, Cleveland DW, Gitlin JD, Wong PC. Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading. Nat Neurosci. 2002 Apr; 5(4):301-7. PMID: 11889469.
      View in: PubMed
    207. Shah JV, Cleveland DW. Slow axonal transport: fast motors in the slow lane. Curr Opin Cell Biol. 2002 Feb; 14(1):58-62. PMID: 11792545.
      View in: PubMed
    208. Howland DS, Liu J, She Y, Goad B, Maragakis NJ, Kim B, Erickson J, Kulik J, DeVito L, Psaltis G, DeGennaro LJ, Cleveland DW, Rothstein JD. Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci U S A. 2002 Feb 05; 99(3):1604-9. PMID: 11818550.
      View in: PubMed
    209. Wataya T, Nunomura A, Smith MA, Siedlak SL, Harris PL, Shimohama S, Szweda LI, Kaminski MA, Avila J, Price DL, Cleveland DW, Sayre LM, Perry G. High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal. J Biol Chem. 2002 Feb 15; 277(7):4644-8. PMID: 11733539.
      View in: PubMed
    210. Cleveland DW, Rothstein JD. From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nat Rev Neurosci. 2001 Nov; 2(11):806-19. PMID: 11715057.
      View in: PubMed
    211. Abrieu A, Magnaghi-Jaulin L, Kahana JA, Peter M, Castro A, Vigneron S, Lorca T, Cleveland DW, Labbé JC. Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint. Cell. 2001 Jul 13; 106(1):83-93. PMID: 11461704.
      View in: PubMed
    212. Skene JP, Cleveland DW. Hypoxia and Lou Gehrig. Nat Genet. 2001 Jun; 28(2):107-8. PMID: 11381249.
      View in: PubMed
    213. Kahana JA, Cleveland DW. Cell cycle. Some importin news about spindle assembly. Science. 2001 Mar 02; 291(5509):1718-9. PMID: 11253198.
      View in: PubMed
    214. Kato S, Nakashima K, Horiuchi S, Nagai R, Cleveland DW, Liu J, Hirano A, Takikawa M, Kato M, Nakano I, Sakoda S, Asayama K, Ohama E. Formation of advanced glycation end-product-modified superoxide dismutase-1 (SOD1) is one of the mechanisms responsible for inclusions common to familial amyotrophic lateral sclerosis patients with SOD1 gene mutation, and transgenic mice expressing human SOD1 gene mutation. Neuropathology. 2001 Mar; 21(1):67-81. PMID: 11304045.
      View in: PubMed
    215. Garcia ML, Cleveland DW. Going new places using an old MAP: tau, microtubules and human neurodegenerative disease. Curr Opin Cell Biol. 2001 Feb; 13(1):41-8. PMID: 11163132.
      View in: PubMed
    216. Shah JV, Cleveland DW. Waiting for anaphase: Mad2 and the spindle assembly checkpoint. Cell. 2000 Dec 22; 103(7):997-1000. PMID: 11163175.
      View in: PubMed
    217. Pasinelli P, Houseweart MK, Brown RH, Cleveland DW. Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2000 Dec 05; 97(25):13901-6. PMID: 11095709.
      View in: PubMed
    218. Cleveland DW, Liu J. Oxidation versus aggregation - how do SOD1 mutants cause ALS? Nat Med. 2000 Dec; 6(12):1320-1. PMID: 11100110.
      View in: PubMed
    219. Sánchez I, Hassinger L, Sihag RK, Cleveland DW, Mohan P, Nixon RA. Local control of neurofilament accumulation during radial growth of myelinating axons in vivo. Selective role of site-specific phosphorylation. J Cell Biol. 2000 Nov 27; 151(5):1013-24. PMID: 11086003.
      View in: PubMed
    220. Kato S, Horiuchi S, Liu J, Cleveland DW, Shibata N, Nakashima K, Nagai R, Hirano A, Takikawa M, Kato M, Nakano I, Ohama E. Advanced glycation endproduct-modified superoxide dismutase-1 (SOD1)-positive inclusions are common to familial amyotrophic lateral sclerosis patients with SOD1 gene mutations and transgenic mice expressing human SOD1 with a G85R mutation. Acta Neuropathol. 2000 Nov; 100(5):490-505. PMID: 11045671.
      View in: PubMed
    221. Abrieu A, Kahana JA, Wood KW, Cleveland DW. CENP-E as an essential component of the mitotic checkpoint in vitro. Cell. 2000 Sep 15; 102(6):817-26. PMID: 11030625.
      View in: PubMed
    222. Yao X, Abrieu A, Zheng Y, Sullivan KF, Cleveland DW. CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint. Nat Cell Biol. 2000 Aug; 2(8):484-91. PMID: 10934468.
      View in: PubMed
    223. Yucel JK, Marszalek JD, McIntosh JR, Goldstein LS, Cleveland DW, Philp AV. CENP-meta, an essential kinetochore kinesin required for the maintenance of metaphase chromosome alignment in Drosophila. J Cell Biol. 2000 Jul 10; 150(1):1-11. PMID: 10893249.
      View in: PubMed
    224. Kato S, Takikawa M, Nakashima K, Hirano A, Cleveland DW, Kusaka H, Shibata N, Kato M, Nakano I, Ohama E. New consensus research on neuropathological aspects of familial amyotrophic lateral sclerosis with superoxide dismutase 1 (SOD1) gene mutations: inclusions containing SOD1 in neurons and astrocytes. Amyotroph Lateral Scler Other Motor Neuron Disord. 2000 Jun; 1(3):163-84. PMID: 11464950.
      View in: PubMed
    225. Merdes A, Heald R, Samejima K, Earnshaw WC, Cleveland DW. Formation of spindle poles by dynein/dynactin-dependent transport of NuMA. J Cell Biol. 2000 May 15; 149(4):851-62. PMID: 10811826.
      View in: PubMed
    226. Williamson TL, Corson LB, Huang L, Burlingame A, Liu J, Bruijn LI, Cleveland DW. Toxicity of ALS-linked SOD1 mutants. Science. 2000 Apr 21; 288(5465):399. PMID: 10798964.
      View in: PubMed
    227. Price DL, Wong PC, Markowska AL, Lee MK, Thinakaren G, Cleveland DW, Sisodia SS, Borchelt DR. The value of transgenic models for the study of neurodegenerative diseases. Ann N Y Acad Sci. 2000; 920:179-91. PMID: 11193148.
      View in: PubMed
    228. Houseweart MK, Cleveland DW. Cytoskeletal linkers: new MAPs for old destinations. Curr Biol. 1999 Nov 18; 9(22):R864-6. PMID: 10574751.
      View in: PubMed
    229. Cleveland DW. From Charcot to SOD1: mechanisms of selective motor neuron death in ALS. Neuron. 1999 Nov; 24(3):515-20. PMID: 10595505.
      View in: PubMed
    230. Corson LB, Folmer J, Strain JJ, Culotta VC, Cleveland DW. Oxidative stress and iron are implicated in fragmenting vacuoles of Saccharomyces cerevisiae lacking Cu,Zn-superoxide dismutase. J Biol Chem. 1999 Sep 24; 274(39):27590-6. PMID: 10488097.
      View in: PubMed
    231. Kahana JA, Cleveland DW. Beyond nuclear transport. Ran-GTP as a determinant of spindle assembly. J Cell Biol. 1999 Sep 20; 146(6):1205-10. PMID: 10491385.
      View in: PubMed
    232. Ratovitski T, Corson LB, Strain J, Wong P, Cleveland DW, Culotta VC, Borchelt DR. Variation in the biochemical/biophysical properties of mutant superoxide dismutase 1 enzymes and the rate of disease progression in familial amyotrophic lateral sclerosis kindreds. Hum Mol Genet. 1999 Aug; 8(8):1451-60. PMID: 10400992.
      View in: PubMed
    233. Houseweart MK, Cleveland DW. Bcl-2 overexpression does not protect neurons from mutant neurofilament-mediated motor neuron degeneration. J Neurosci. 1999 Aug 01; 19(15):6446-56. PMID: 10414973.
      View in: PubMed
    234. Williamson TL, Cleveland DW. Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons. Nat Neurosci. 1999 Jan; 2(1):50-6. PMID: 10195180.
      View in: PubMed
    235. Rothstein JD, Dykes-Hoberg M, Corson LB, Becker M, Cleveland DW, Price DL, Culotta VC, Wong PC. The copper chaperone CCS is abundant in neurons and astrocytes in human and rodent brain. J Neurochem. 1999 Jan; 72(1):422-9. PMID: 9886096.
      View in: PubMed
    236. Pasinelli P, Borchelt DR, Houseweart MK, Cleveland DW, Brown RH. Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase. Proc Natl Acad Sci U S A. 1998 Dec 22; 95(26):15763-8. PMID: 9861044.
      View in: PubMed
    237. Rao MV, Houseweart MK, Williamson TL, Crawford TO, Folmer J, Cleveland DW. Neurofilament-dependent radial growth of motor axons and axonal organization of neurofilaments does not require the neurofilament heavy subunit (NF-H) or its phosphorylation. J Cell Biol. 1998 Oct 05; 143(1):171-81. PMID: 9763429.
      View in: PubMed
    238. Bruijn LI, Houseweart MK, Kato S, Anderson KL, Anderson SD, Ohama E, Reaume AG, Scott RW, Cleveland DW. Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1. Science. 1998 Sep 18; 281(5384):1851-4. PMID: 9743498.
      View in: PubMed
    239. Williamson TL, Bruijn LI, Zhu Q, Anderson KL, Anderson SD, Julien JP, Cleveland DW. Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutant. Proc Natl Acad Sci U S A. 1998 Aug 04; 95(16):9631-6. PMID: 9689132.
      View in: PubMed
    240. Couillard-Després S, Zhu Q, Wong PC, Price DL, Cleveland DW, Julien JP. Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase. Proc Natl Acad Sci U S A. 1998 Aug 04; 95(16):9626-30. PMID: 9689131.
      View in: PubMed
    241. Borchelt DR, Wong PC, Becher MW, Pardo CA, Lee MK, Xu ZS, Thinakaran G, Jenkins NA, Copeland NG, Sisodia SS, Cleveland DW, Price DL, Hoffman PN. Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice. Neurobiol Dis. 1998 Jul; 5(1):27-35. PMID: 9702785.
      View in: PubMed
    242. Corson LB, Strain JJ, Culotta VC, Cleveland DW. Chaperone-facilitated copper binding is a property common to several classes of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants. Proc Natl Acad Sci U S A. 1998 May 26; 95(11):6361-6. PMID: 9600970.
      View in: PubMed
    243. Eyer J, Cleveland DW, Wong PC, Peterson AC. Pathogenesis of two axonopathies does not require axonal neurofilaments. Nature. 1998 Feb 05; 391(6667):584-7. PMID: 9468135.
      View in: PubMed
    244. Houseweart MK, Cleveland DW. Intermediate filaments and their associated proteins: multiple dynamic personalities. Curr Opin Cell Biol. 1998 Feb; 10(1):93-101. PMID: 9484600.
      View in: PubMed
    245. Fuchs E, Cleveland DW. A structural scaffolding of intermediate filaments in health and disease. Science. 1998 Jan 23; 279(5350):514-9. PMID: 9438837.
      View in: PubMed
    246. Merdes A, Cleveland DW. The role of NuMA in the interphase nucleus. J Cell Sci. 1998 Jan; 111 ( Pt 1):71-9. PMID: 9394013.
      View in: PubMed
    247. Wood KW, Sakowicz R, Goldstein LS, Cleveland DW. CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment. Cell. 1997 Oct 31; 91(3):357-66. PMID: 9363944.
      View in: PubMed
    248. Yao X, Anderson KL, Cleveland DW. The microtubule-dependent motor centromere-associated protein E (CENP-E) is an integral component of kinetochore corona fibers that link centromeres to spindle microtubules. J Cell Biol. 1997 Oct 20; 139(2):435-47. PMID: 9334346.
      View in: PubMed
    249. Merdes A, Cleveland DW. Pathways of spindle pole formation: different mechanisms; conserved components. J Cell Biol. 1997 Sep 08; 138(5):953-6. PMID: 9281574.
      View in: PubMed
    250. Duesbery NS, Choi T, Brown KD, Wood KW, Resau J, Fukasawa K, Cleveland DW, Vande Woude GF. CENP-E is an essential kinetochore motor in maturing oocytes and is masked during mos-dependent, cell cycle arrest at metaphase II. Proc Natl Acad Sci U S A. 1997 Aug 19; 94(17):9165-70. PMID: 9256453.
      View in: PubMed
    251. Bruijn LI, Beal MF, Becher MW, Schulz JB, Wong PC, Price DL, Cleveland DW. Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant. Proc Natl Acad Sci U S A. 1997 Jul 08; 94(14):7606-11. PMID: 9207139.
      View in: PubMed
    252. Bruijn LI, Becher MW, Lee MK, Anderson KL, Jenkins NA, Copeland NG, Sisodia SS, Rothstein JD, Borchelt DR, Price DL, Cleveland DW. ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron. 1997 Feb; 18(2):327-38. PMID: 9052802.
      View in: PubMed
    253. Marszalek JR, Williamson TL, Lee MK, Xu Z, Hoffman PN, Becher MW, Crawford TO, Cleveland DW. Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transport. J Cell Biol. 1996 Nov; 135(3):711-24. PMID: 8909545.
      View in: PubMed
    254. Merdes A, Ramyar K, Vechio JD, Cleveland DW. A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly. Cell. 1996 Nov 01; 87(3):447-58. PMID: 8898198.
      View in: PubMed
    255. Vechio JD, Bruijn LI, Xu Z, Brown RH, Cleveland DW. Sequence variants in human neurofilament proteins: absence of linkage to familial amyotrophic lateral sclerosis. Ann Neurol. 1996 Oct; 40(4):603-10. PMID: 8871580.
      View in: PubMed
    256. Cleveland DW, Bruijn LI, Wong PC, Marszalek JR, Vechio JD, Lee MK, Xu XS, Borchelt DR, Sisodia SS, Price DL. Mechanisms of selective motor neuron death in transgenic mouse models of motor neuron disease. Neurology. 1996 Oct; 47(4 Suppl 2):S54-61; discussion S61-2. PMID: 8858052.
      View in: PubMed
    257. Bruijn LI, Cleveland DW. Mechanisms of selective motor neuron death in ALS: insights from transgenic mouse models of motor neuron disease. Neuropathol Appl Neurobiol. 1996 Oct; 22(5):373-87. PMID: 8930947.
      View in: PubMed
    258. Yang Y, Dowling J, Yu QC, Kouklis P, Cleveland DW, Fuchs E. An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments. Cell. 1996 Aug 23; 86(4):655-65. PMID: 8752219.
      View in: PubMed
    259. Dong DL, Xu ZS, Hart GW, Cleveland DW. Cytoplasmic O-GlcNAc modification of the head domain and the KSP repeat motif of the neurofilament protein neurofilament-H. J Biol Chem. 1996 Aug 23; 271(34):20845-52. PMID: 8702840.
      View in: PubMed
    260. Xu Z, Marszalek JR, Lee MK, Wong PC, Folmer J, Crawford TO, Hsieh ST, Griffin JW, Cleveland DW. Subunit composition of neurofilaments specifies axonal diameter. J Cell Biol. 1996 Jun; 133(5):1061-9. PMID: 8655579.
      View in: PubMed
    261. Brown KD, Wood KW, Cleveland DW. The kinesin-like protein CENP-E is kinetochore-associated throughout poleward chromosome segregation during anaphase-A. J Cell Sci. 1996 May; 109 ( Pt 5):961-9. PMID: 8743943.
      View in: PubMed
    262. Cleveland DW. Neuronal growth and death: order and disorder in the axoplasm. Cell. 1996 Mar 08; 84(5):663-6. PMID: 8625404.
      View in: PubMed
    263. Price DL, Koliatsos VE, Wong PC, Pardo CA, Borchelt DR, Lee MK, Cleveland DW, Griffin JW, Hoffman PN, Cork LC, Sisodia SS. Motor neuron disease and model systems: aetiologies, mechanisms and therapies. Ciba Found Symp. 1996; 196:3-13; discussion 13-7. PMID: 8866125.
      View in: PubMed
    264. Lee MK, Cleveland DW. Neuronal intermediate filaments. Annu Rev Neurosci. 1996; 19:187-217. PMID: 8833441.
      View in: PubMed
    265. Williamson TL, Marszalek JR, Vechio JD, Bruijn LI, Lee MK, Xu Z, Brown RH, Cleveland DW. Neurofilaments, radial growth of axons, and mechanisms of motor neuron disease. Cold Spring Harb Symp Quant Biol. 1996; 61:709-23. PMID: 9246497.
      View in: PubMed
    266. Price DL, Borchelt DR, Wong PC, Pardo CA, Thinakaran G, Lee MK, Cleveland DW, Sisodia SS. Neurodegenerative diseases and model systems. Cold Spring Harb Symp Quant Biol. 1996; 61:725-38. PMID: 9246498.
      View in: PubMed
    267. Cleveland DW, Laing N, Hurse PV, Brown RH. Toxic mutants in Charcot's sclerosis. Nature. 1995 Nov 23; 378(6555):342-3. PMID: 7477368.
      View in: PubMed
    268. Wong PC, Marszalek J, Crawford TO, Xu Z, Hsieh ST, Griffin JW, Cleveland DW. Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons. J Cell Biol. 1995 Sep; 130(6):1413-22. PMID: 7559762.
      View in: PubMed
    269. Wong PC, Pardo CA, Borchelt DR, Lee MK, Copeland NG, Jenkins NA, Sisodia SS, Cleveland DW, Price DL. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron. 1995 Jun; 14(6):1105-16. PMID: 7605627.
      View in: PubMed
    270. Sauter ER, Ridge JA, Trock B, Cleveland D, Whitley KV, Mohr RM, Klein-Szanto A. Overexpression of the p53 gene in primary and metastatic head and neck carcinomas. Laryngoscope. 1995 Jun; 105(6):653-6. PMID: 7769953.
      View in: PubMed
    271. Borchelt DR, Guarnieri M, Wong PC, Lee MK, Slunt HS, Xu ZS, Sisodia SS, Price DL, Cleveland DW. Superoxide dismutase 1 subunits with mutations linked to familial amyotrophic lateral sclerosis do not affect wild-type subunit function. J Biol Chem. 1995 Feb 17; 270(7):3234-8. PMID: 7852409.
      View in: PubMed
    272. Pardo CA, Xu Z, Borchelt DR, Price DL, Sisodia SS, Cleveland DW. Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons. Proc Natl Acad Sci U S A. 1995 Feb 14; 92(4):954-8. PMID: 7862672.
      View in: PubMed
    273. Cleveland DW. NuMA: a protein involved in nuclear structure, spindle assembly, and nuclear re-formation. Trends Cell Biol. 1995 Feb; 5(2):60-4. PMID: 14731413.
      View in: PubMed
    274. Price DL, Cleveland DW, Koliatsos VE. Motor neurone disease and animal models. Neurobiol Dis. 1994 Nov; 1(1-2):3-11. PMID: 9216981.
      View in: PubMed
    275. Hsieh ST, Kidd GJ, Crawford TO, Xu Z, Lin WM, Trapp BD, Cleveland DW, Griffin JW. Regional modulation of neurofilament organization by myelination in normal axons. J Neurosci. 1994 Nov; 14(11 Pt 1):6392-401. PMID: 7965044.
      View in: PubMed
    276. Sauter ER, Cleveland D, Trock B, Ridge JA, Klein-Szanto AJ. p53 is overexpressed in fifty percent of pre-invasive lesions of head and neck epithelium. Carcinogenesis. 1994 Oct; 15(10):2269-74. PMID: 7955065.
      View in: PubMed
    277. Lee MK, Marszalek JR, Cleveland DW. A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease. Neuron. 1994 Oct; 13(4):975-88. PMID: 7946341.
      View in: PubMed
    278. Xu Z, Dong DL, Cleveland DW. Neuronal intermediate filaments: new progress on an old subject. Curr Opin Neurobiol. 1994 Oct; 4(5):655-61. PMID: 7849521.
      View in: PubMed
    279. Borchelt DR, Lee MK, Slunt HS, Guarnieri M, Xu ZS, Wong PC, Brown RH, Price DL, Sisodia SS, Cleveland DW. Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. Proc Natl Acad Sci U S A. 1994 Aug 16; 91(17):8292-6. PMID: 8058797.
      View in: PubMed
    280. Brown KD, Coulson RM, Yen TJ, Cleveland DW. Cyclin-like accumulation and loss of the putative kinetochore motor CENP-E results from coupling continuous synthesis with specific degradation at the end of mitosis. J Cell Biol. 1994 Jun; 125(6):1303-12. PMID: 8207059.
      View in: PubMed
    281. Compton DA, Cleveland DW. NuMA, a nuclear protein involved in mitosis and nuclear reformation. Curr Opin Cell Biol. 1994 Jun; 6(3):343-6. PMID: 7917323.
      View in: PubMed
    282. Bachurski CJ, Theodorakis NG, Coulson RM, Cleveland DW. An amino-terminal tetrapeptide specifies cotranslational degradation of beta-tubulin but not alpha-tubulin mRNAs. Mol Cell Biol. 1994 Jun; 14(6):4076-86. PMID: 8196646.
      View in: PubMed
    283. Gill SR, Cleveland DW, Schroer TA. Characterization of DLC-A and DLC-B, two families of cytoplasmic dynein light chain subunits. Mol Biol Cell. 1994 Jun; 5(6):645-54. PMID: 7949421.
      View in: PubMed
    284. Lee MK, Cleveland DW. Neurofilament function and dysfunction: involvement in axonal growth and neuronal disease. Curr Opin Cell Biol. 1994 Feb; 6(1):34-40. PMID: 7513179.
      View in: PubMed
    285. Katz DA, Theodorakis NG, Cleveland DW, Lindsten T, Thompson CB. AU-A, an RNA-binding activity distinct from hnRNP A1, is selective for AUUUA repeats and shuttles between the nucleus and the cytoplasm. Nucleic Acids Res. 1994 Jan 25; 22(2):238-46. PMID: 8121809.
      View in: PubMed
    286. Heins S, Wong PC, Müller S, Goldie K, Cleveland DW, Aebi U. The rod domain of NF-L determines neurofilament architecture, whereas the end domains specify filament assembly and network formation. J Cell Biol. 1993 Dec; 123(6 Pt 1):1517-33. PMID: 8253847.
      View in: PubMed
    287. Lee MK, Xu Z, Wong PC, Cleveland DW. Neurofilaments are obligate heteropolymers in vivo. J Cell Biol. 1993 Sep; 122(6):1337-50. PMID: 8376466.
      View in: PubMed
    288. Coulson RM, Cleveland DW. Ferritin synthesis is controlled by iron-dependent translational derepression and by changes in synthesis/transport of nuclear ferritin RNAs. Proc Natl Acad Sci U S A. 1993 Aug 15; 90(16):7613-7. PMID: 8356063.
      View in: PubMed
    289. Dong DL, Xu ZS, Chevrier MR, Cotter RJ, Cleveland DW, Hart GW. Glycosylation of mammalian neurofilaments. Localization of multiple O-linked N-acetylglucosamine moieties on neurofilament polypeptides L and M. J Biol Chem. 1993 Aug 05; 268(22):16679-87. PMID: 8344946.
      View in: PubMed
    290. Xu Z, Cork LC, Griffin JW, Cleveland DW. Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease. Cell. 1993 Apr 09; 73(1):23-33. PMID: 8462100.
      View in: PubMed
    291. Compton DA, Cleveland DW. NuMA is required for the proper completion of mitosis. J Cell Biol. 1993 Feb; 120(4):947-57. PMID: 8432734.
      View in: PubMed
    292. Xu Z, Cork LC, Griffin JW, Cleveland DW. Involvement of neurofilaments in motor neuron disease. J Cell Sci Suppl. 1993; 17:101-8. PMID: 8144684.
      View in: PubMed
    293. Cleveland DW, Hinnebusch AG. Post-transcriptional processes. Curr Opin Cell Biol. 1992 Dec; 4(6):973-4. PMID: 1485967.
      View in: PubMed
    294. Yen TJ, Li G, Schaar BT, Szilak I, Cleveland DW. CENP-E is a putative kinetochore motor that accumulates just before mitosis. Nature. 1992 Oct 08; 359(6395):536-9. PMID: 1406971.
      View in: PubMed
    295. Savant-Bhonsale S, Cleveland DW. Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a > 20S degradation complex. Genes Dev. 1992 Oct; 6(10):1927-39. PMID: 1398070.
      View in: PubMed
    296. Joshi HC, Palacios MJ, McNamara L, Cleveland DW. Gamma-tubulin is a centrosomal protein required for cell cycle-dependent microtubule nucleation. Nature. 1992 Mar 05; 356(6364):80-3. PMID: 1538786.
      View in: PubMed
    297. Compton DA, Szilak I, Cleveland DW. Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis. J Cell Biol. 1992 Mar; 116(6):1395-408. PMID: 1541636.
      View in: PubMed
    298. Theodorakis NG, Cleveland DW. Physical evidence for cotranslational regulation of beta-tubulin mRNA degradation. Mol Cell Biol. 1992 Feb; 12(2):791-9. PMID: 1732744.
      View in: PubMed
    299. Gill SR, Schroer TA, Szilak I, Steuer ER, Sheetz MP, Cleveland DW. Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein. J Cell Biol. 1991 Dec; 115(6):1639-50. PMID: 1836789.
      View in: PubMed
    300. Cleveland DW, Hoffman PN. Slow axonal transport models come full circle: evidence that microtubule sliding mediates axon elongation and tubulin transport. Cell. 1991 Nov 01; 67(3):453-6. PMID: 1718604.
      View in: PubMed
    301. Cleveland DW, Hoffman PN. Neuronal and glial cytoskeletons. Curr Opin Neurobiol. 1991 Oct; 1(3):346-53. PMID: 1821676.
      View in: PubMed
    302. Yen TJ, Compton DA, Wise D, Zinkowski RP, Brinkley BR, Earnshaw WC, Cleveland DW. CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase. EMBO J. 1991 May; 10(5):1245-54. PMID: 2022189.
      View in: PubMed
    303. Compton DA, Yen TJ, Cleveland DW. Identification of novel centromere/kinetochore-associated proteins using monoclonal antibodies generated against human mitotic chromosome scaffolds. J Cell Biol. 1991 Mar; 112(6):1083-97. PMID: 1999466.
      View in: PubMed
    304. Zhou RP, Oskarsson M, Paules RS, Schulz N, Cleveland D, Vande Woude GF. Ability of the c-mos product to associate with and phosphorylate tubulin. Science. 1991 Feb 08; 251(4994):671-5. PMID: 1825142.
      View in: PubMed
    305. Cleveland DW, Monteiro MJ, Wong PC, Gill SR, Gearhart JD, Hoffman PN. Involvement of neurofilaments in the radial growth of axons. J Cell Sci Suppl. 1991; 15:85-95. PMID: 1824110.
      View in: PubMed
    306. Wong PC, Cleveland DW. Characterization of dominant and recessive assembly-defective mutations in mouse neurofilament NF-M. J Cell Biol. 1990 Nov; 111(5 Pt 1):1987-2003. PMID: 2121743.
      View in: PubMed
    307. Gill SR, Wong PC, Monteiro MJ, Cleveland DW. Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit. J Cell Biol. 1990 Nov; 111(5 Pt 1):2005-19. PMID: 2121744.
      View in: PubMed
    308. Monteiro MJ, Hoffman PN, Gearhart JD, Cleveland DW. Expression of NF-L in both neuronal and nonneuronal cells of transgenic mice: increased neurofilament density in axons without affecting caliber. J Cell Biol. 1990 Oct; 111(4):1543-57. PMID: 2120242.
      View in: PubMed
    309. D'Arpa P, White-Cooper H, Cleveland DW, Rothfield NF, Earnshaw WC. Use of molecular cloning methods to map the distribution of epitopes on topoisomerase I (Scl-70) recognized by sera of scleroderma patients. Arthritis Rheum. 1990 Oct; 33(10):1501-11. PMID: 1699543.
      View in: PubMed
    310. Cleveland D, Abrams AM, Melrose RJ, Handlers JP. Solid adenoid cystic carcinoma of the maxilla. Oral Surg Oral Med Oral Pathol. 1990 Apr; 69(4):470-8. PMID: 2158031.
      View in: PubMed
    311. Pandya K, Wilcox J, Khaw H, Cleveland D, Sharma OP. Lung abscess secondary to xanthogranulomatous pyelonephritis. Thorax. 1990 Apr; 45(4):297-9. PMID: 2356557.
      View in: PubMed
    312. Cleveland DW, Joshi HC, Murphy DB. Tubulin site interpretation. Nature. 1990 Mar 29; 344(6265):389. PMID: 2138712.
      View in: PubMed
    313. Cleveland DW. Microtubule MAPping. Cell. 1990 Mar 09; 60(5):701-2. PMID: 2107023.
      View in: PubMed
    314. Gabriel A, Yen TJ, Schwartz DC, Smith CL, Boeke JD, Sollner-Webb B, Cleveland DW. A rapidly rearranging retrotransposon within the miniexon gene locus of Crithidia fasciculata. Mol Cell Biol. 1990 Feb; 10(2):615-24. PMID: 2153919.
      View in: PubMed
    315. Lee MK, Tuttle JB, Rebhun LI, Cleveland DW, Frankfurter A. The expression and posttranslational modification of a neuron-specific beta-tubulin isotype during chick embryogenesis. Cell Motil Cytoskeleton. 1990; 17(2):118-32. PMID: 2257630.
      View in: PubMed
    316. Joshi HC, Cleveland DW. Diversity among tubulin subunits: toward what functional end? Cell Motil Cytoskeleton. 1990; 16(3):159-63. PMID: 2194680.
      View in: PubMed
    317. Sisodia SS, Gay DA, Cleveland DW. In vivo discrimination among beta-tubulin isotypes: selective degradation of a type IV beta-tubulin isotype following overexpression in cultured animal cells. New Biol. 1990 Jan; 2(1):66-76. PMID: 2078553.
      View in: PubMed
    318. Cleveland DW. Gene regulation through messenger RNA stability. Curr Opin Cell Biol. 1989 Dec; 1(6):1148-53. PMID: 2699801.
      View in: PubMed
    319. Cleveland DW, Yen TJ. Multiple determinants of eukaryotic mRNA stability. New Biol. 1989 Nov; 1(2):121-6. PMID: 2518709.
      View in: PubMed
    320. Gay DA, Sisodia SS, Cleveland DW. Autoregulatory control of beta-tubulin mRNA stability is linked to translation elongation. Proc Natl Acad Sci U S A. 1989 Aug; 86(15):5763-7. PMID: 2762294.
      View in: PubMed
    321. Joshi HC, Cleveland DW. Differential utilization of beta-tubulin isotypes in differentiating neurites. J Cell Biol. 1989 Aug; 109(2):663-73. PMID: 2503525.
      View in: PubMed
    322. Cleveland DW. Autoregulated control of tubulin synthesis in animal cells. Curr Opin Cell Biol. 1989 Feb; 1(1):10-4. PMID: 2629858.
      View in: PubMed
    323. Monteiro MJ, Cleveland DW. Expression of NF-L and NF-M in fibroblasts reveals coassembly of neurofilament and vimentin subunits. J Cell Biol. 1989 Feb; 108(2):579-93. PMID: 2493000.
      View in: PubMed
    324. Cleveland DW. Use of DNA transfection to analyze gene regulation and function in animal cells: dissection of the tubulin multigene family. Cell Motil Cytoskeleton. 1989; 14(1):147-55. PMID: 2684421.
      View in: PubMed
    325. Cleveland DW. Autoregulated instability of tubulin mRNAs: a novel eukaryotic regulatory mechanism. Trends Biochem Sci. 1988 Sep; 13(9):339-43. PMID: 3072712.
      View in: PubMed
    326. Yen TJ, Machlin PS, Cleveland DW. Autoregulated instability of beta-tubulin mRNAs by recognition of the nascent amino terminus of beta-tubulin. Nature. 1988 Aug 18; 334(6183):580-5. PMID: 3405308.
      View in: PubMed
    327. Hoffman PN, Cleveland DW. Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration: induction of a specific beta-tubulin isotype. Proc Natl Acad Sci U S A. 1988 Jun; 85(12):4530-3. PMID: 3132717.
      View in: PubMed
    328. Pratt LF, Cleveland DW. A survey of the alpha-tubulin gene family in chicken: unexpected sequence heterogeneity in the polypeptides encoded by five expressed genes. EMBO J. 1988 Apr; 7(4):931-40. PMID: 3267229.
      View in: PubMed
    329. D'Arpa P, Machlin PS, Ratrie H, Rothfield NF, Cleveland DW, Earnshaw WC. cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment. Proc Natl Acad Sci U S A. 1988 Apr; 85(8):2543-7. PMID: 2833744.
      View in: PubMed
    330. Yen TJ, Gay DA, Pachter JS, Cleveland DW. Autoregulated changes in stability of polyribosome-bound beta-tubulin mRNAs are specified by the first 13 translated nucleotides. Mol Cell Biol. 1988 Mar; 8(3):1224-35. PMID: 2835666.
      View in: PubMed
    331. Monteiro MJ, Cleveland DW. Sequence of chicken c beta 7 tubulin. Analysis of a complete set of vertebrate beta-tubulin isotypes. J Mol Biol. 1988 Feb 05; 199(3):439-46. PMID: 3351937.
      View in: PubMed
    332. Gabriel A, Sisodia SS, Cleveland DW. Evidence of discontinuous transcription in the trypanosomatid Crithidia fasciculata. J Biol Chem. 1987 Nov 25; 262(33):16192-9. PMID: 3680249.
      View in: PubMed
    333. Joshi HC, Yen TJ, Cleveland DW. In vivo coassembly of a divergent beta-tubulin subunit (c beta 6) into microtubules of different function. J Cell Biol. 1987 Nov; 105(5):2179-90. PMID: 3316249.
      View in: PubMed
    334. Pachter JS, Yen TJ, Cleveland DW. Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs. Cell. 1987 Oct 23; 51(2):283-92. PMID: 2444342.
      View in: PubMed
    335. Murphy DB, Wallis KT, Machlin PS, Ratrie H, Cleveland DW. The sequence and expression of the divergent beta-tubulin in chicken erythrocytes. J Biol Chem. 1987 Oct 15; 262(29):14305-12. PMID: 2888766.
      View in: PubMed
    336. Sisodia SS, Sollner-Webb B, Cleveland DW. Specificity of RNA maturation pathways: RNAs transcribed by RNA polymerase III are not substrates for splicing or polyadenylation. Mol Cell Biol. 1987 Oct; 7(10):3602-12. PMID: 3683396.
      View in: PubMed
    337. Lopata MA, Cleveland DW. In vivo microtubules are copolymers of available beta-tubulin isotypes: localization of each of six vertebrate beta-tubulin isotypes using polyclonal antibodies elicited by synthetic peptide antigens. J Cell Biol. 1987 Oct; 105(4):1707-20. PMID: 3312237.
      View in: PubMed
    338. Gay DA, Yen TJ, Lau JT, Cleveland DW. Sequences that confer beta-tubulin autoregulation through modulated mRNA stability reside within exon 1 of a beta-tubulin mRNA. Cell. 1987 Aug 28; 50(5):671-9. PMID: 3621343.
      View in: PubMed
    339. Earnshaw WC, Machlin PS, Bordwell BJ, Rothfield NF, Cleveland DW. Analysis of anticentromere autoantibodies using cloned autoantigen CENP-B. Proc Natl Acad Sci U S A. 1987 Jul; 84(14):4979-83. PMID: 2440036.
      View in: PubMed
    340. Hoffman PN, Cleveland DW, Griffin JW, Landes PW, Cowan NJ, Price DL. Neurofilament gene expression: a major determinant of axonal caliber. Proc Natl Acad Sci U S A. 1987 May; 84(10):3472-6. PMID: 3472217.
      View in: PubMed
    341. Earnshaw WC, Sullivan KF, Machlin PS, Cooke CA, Kaiser DA, Pollard TD, Rothfield NF, Cleveland DW. Molecular cloning of cDNA for CENP-B, the major human centromere autoantigen. J Cell Biol. 1987 Apr; 104(4):817-29. PMID: 2435739.
      View in: PubMed
    342. Sisodia SS, Cleveland DW, Sollner-Webb B. A combination of RNase H and S1 nuclease circumvents an artefact inherent to conventional S1 analysis of RNA splicing. Nucleic Acids Res. 1987 Mar 11; 15(5):1995-2011. PMID: 3031584.
      View in: PubMed
    343. Cleveland DW. The multitubulin hypothesis revisited: what have we learned? J Cell Biol. 1987 Mar; 104(3):381-3. PMID: 3546332.
      View in: PubMed
    344. Pratt LF, Okamura S, Cleveland DW. A divergent testis-specific alpha-tubulin isotype that does not contain a coded C-terminal tyrosine. Mol Cell Biol. 1987 Jan; 7(1):552-5. PMID: 3561402.
      View in: PubMed
    345. Sullivan KF, Havercroft JC, Machlin PS, Cleveland DW. Sequence and expression of the chicken beta 5- and beta 4-tubulin genes define a pair of divergent beta-tubulins with complementary patterns of expression. Mol Cell Biol. 1986 Dec; 6(12):4409-18. PMID: 3025656.
      View in: PubMed
    346. Sullivan KF, Machlin PS, Ratrie H, Cleveland DW. Sequence and expression of the chicken beta 3 tubulin gene. A vertebrate testis beta-tubulin isotype. J Biol Chem. 1986 Oct 05; 261(28):13317-22. PMID: 3759966.
      View in: PubMed
    347. Lopata MA, Cleveland DW, Sollner-Webb B. RNA polymerase specificity of mRNA production and enhancer action. Proc Natl Acad Sci U S A. 1986 Sep; 83(18):6677-81. PMID: 3462718.
      View in: PubMed
    348. Sullivan KF, Cleveland DW. Identification of conserved isotype-defining variable region sequences for four vertebrate beta tubulin polypeptide classes. Proc Natl Acad Sci U S A. 1986 Jun; 83(12):4327-31. PMID: 3459176.
      View in: PubMed
    349. Lau JT, Pittenger MF, Havercroft JC, Cleveland DW. Reconstruction of tubulin gene regulation in cultured mammalian cells. Ann N Y Acad Sci. 1986; 466:75-88. PMID: 3460447.
      View in: PubMed
    350. Pittenger MF, Cleveland DW. Retention of autoregulatory control of tubulin synthesis in cytoplasts: demonstration of a cytoplasmic mechanism that regulates the level of tubulin expression. J Cell Biol. 1985 Nov; 101(5 Pt 1):1941-52. PMID: 4055901.
      View in: PubMed
    351. Sullivan KF, Lau JT, Cleveland DW. Apparent gene conversion between beta-tubulin genes yields multiple regulatory pathways for a single beta-tubulin polypeptide isotype. Mol Cell Biol. 1985 Sep; 5(9):2454-65. PMID: 3837190.
      View in: PubMed
    352. Lau JT, Pittenger MF, Cleveland DW. Reconstruction of appropriate tubulin and actin gene regulation after transient transfection of cloned beta-tubulin and beta-actin genes. Mol Cell Biol. 1985 Jul; 5(7):1611-20. PMID: 4022009.
      View in: PubMed
    353. Cleveland DW, Sullivan KF. Molecular biology and genetics of tubulin. Annu Rev Biochem. 1985; 54:331-65. PMID: 3896122.
      View in: PubMed
    354. Havercroft JC, Cleveland DW. Programmed expression of beta-tubulin genes during development and differentiation of the chicken. J Cell Biol. 1984 Dec; 99(6):1927-35. PMID: 6094589.
      View in: PubMed
    355. Sullivan KF, Cleveland DW. Sequence of a highly divergent beta tubulin gene reveals regional heterogeneity in the beta tubulin polypeptide. J Cell Biol. 1984 Nov; 99(5):1754-60. PMID: 6490718.
      View in: PubMed
    356. Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW. Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. Mol Cell Biol. 1983 Oct; 3(10):1738-45. PMID: 6646120.
      View in: PubMed
    357. Cleveland DW, Pittenger MF, Feramisco JR. Elevation of tubulin levels by microinjection suppresses new tubulin synthesis. Nature. 1983 Oct 20-26; 305(5936):738-40. PMID: 6633643.
      View in: PubMed
    358. Cleveland DW, Havercroft JC. Is apparent autoregulatory control of tubulin synthesis nontranscriptionally regulated? J Cell Biol. 1983 Sep; 97(3):919-24. PMID: 6885926.
      View in: PubMed
    359. Cleveland DW. The tubulins: from DNA to RNA to protein and back again. Cell. 1983 Sep; 34(2):330-2. PMID: 6193888.
      View in: PubMed
    360. Milner RJ, Brow MD, Cleveland DW, Shinnick TM, Sutcliffe JG. Glyceraldehyde 3-phosphate dehydrogenase protein and mRNA are both differentially expressed in adult chickens but not chick embryos. Nucleic Acids Res. 1983 May 25; 11(10):3301-15. PMID: 6687938.
      View in: PubMed
    361. Lopata MA, Havercroft JC, Chow LT, Cleveland DW. Four unique genes required for beta tubulin expression in vertebrates. Cell. 1983 Mar; 32(3):713-24. PMID: 6831558.
      View in: PubMed
    362. Cleveland DW, Pittenger MF, Lopata MA. Autoregulatory control of expression of alpha and beta tubulin. J Submicrosc Cytol. 1983 Jan; 15(1):353-8. PMID: 6188853.
      View in: PubMed
    363. Cleveland DW. Treadmilling of tubulin and actin. Cell. 1982 Apr; 28(4):689-91. PMID: 7046949.
      View in: PubMed
    364. Cleveland D, Kirschner M. Autoregulatory control of the expression of alpha- and beta-tubulins: implications for microtubule assembly. Cold Spring Harb Symp Quant Biol. 1982; 46 Pt 1:171-83. PMID: 6286212.
      View in: PubMed
    365. Sonenberg N, Guertin D, Cleveland D, Trachsel H. Probing the function of the eucaryotic 5' cap structure by using a monoclonal antibody directed against cap-binding proteins. Cell. 1981 Dec; 27(3 Pt 2):563-72. PMID: 6101207.
      View in: PubMed
    366. Fuchs EV, Coppock SM, Green H, Cleveland DW. Two distinct classes of keratin genes and their evolutionary significance. Cell. 1981 Nov; 27(1 Pt 2):75-84. PMID: 6173133.
      View in: PubMed
    367. Cleveland DW, Lopata MA, Sherline P, Kirschner MW. Unpolymerized tubulin modulates the level of tubulin mRNAs. Cell. 1981 Aug; 25(2):537-46. PMID: 6116546.
      View in: PubMed
    368. Valenzuela P, Quiroga M, Zaldivar J, Rutter WJ, Kirschner MW, Cleveland DW. Nucleotide and corresponding amino acid sequences encoded by alpha and beta tubulin mRNAs. Nature. 1981 Feb 19; 289(5799):650-5. PMID: 7464932.
      View in: PubMed
    369. Sánchez F, Natzle JE, Cleveland DW, Kirschner MW, McCarthy BJ. A dispersed multigene family encoding tubulin in Drosophila melanogaster. Cell. 1980 Dec; 22(3):845-54. PMID: 6780200.
      View in: PubMed
    370. Cleveland DW, Lopata MA, MacDonald RJ, Cowan NJ, Rutter WJ, Kirschner MW. Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell. 1980 May; 20(1):95-105. PMID: 6893015.
      View in: PubMed
    371. Cleveland DW, Spiegelman BM, Kirschner MW. Conservation of microtubule associated proteins. Isolation and characterization of tau and the high molecular weight microtubule associated protein from chicken brain and from mouse fibroblasts and comparison to the corresponding mammalian brain proteins. J Biol Chem. 1979 Dec 25; 254(24):12670-8. PMID: 227904.
      View in: PubMed
    372. Cleveland DW, Kirschner MW, Cowan NJ. Isolation of separate mRNAs for alpha- and beta-tubulin and characterization of the corresponding in vitro translation products. Cell. 1978 Nov; 15(3):1021-31. PMID: 728983.
      View in: PubMed
    373. Connolly JA, Kalnins VI, Cleveland DW, Kirschner MW. Intracellular localization of the high molecular weight microtubule accessory protein by indirect immunofluorescence. J Cell Biol. 1978 Mar; 76(3):781-6. PMID: 344329.
      View in: PubMed
    374. Cleveland DW, Hwo SY, Kirschner MW. Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. J Mol Biol. 1977 Oct 25; 116(2):207-25. PMID: 599557.
      View in: PubMed
    375. Cleveland DW, Hwo SY, Kirschner MW. Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly. J Mol Biol. 1977 Oct 25; 116(2):227-47. PMID: 146092.
      View in: PubMed
    376. Connolly JA, Kalnins VI, Cleveland DW, Kirschner MW. Immunoflourescent staining of cytoplasmic and spindle microtubules in mouse fibroblasts with antibody to tau protein. Proc Natl Acad Sci U S A. 1977 Jun; 74(6):2437-40. PMID: 329285.
      View in: PubMed
    377. Witman GB, Cleveland DW, Weingarten MD, Kirschner MW. Tubulin requires tau for growth onto microtubule initiating sites. Proc Natl Acad Sci U S A. 1976 Nov; 73(11):4070-4. PMID: 1069293.
      View in: PubMed