Loading...

Paula Desplats

Title(s)Assistant Adjunct Professor, Neurosciences
SchoolHealth Sciences
Address9500 Gilman Drive #0624
La Jolla CA 92093
Phone858-822-3182
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Circadian dysfunction and Epigenetic alterations in the pathogenesis of Alzheimer's Disease
    NIH/NIA R01AG061831Feb 1, 2019 - Nov 30, 2023
    Role: Principal Investigator
    Applying DNA methylation for differential diagnosis in Lewy Body Dementia
    NIH/NINDS R03NS104013Sep 25, 2017 - Aug 31, 2019
    Role: Principal Investigator
    Regulation of the oligodendroglial accumulation of alpha-synuclein in Multiple System Atrophy
    NIH/NINDS R01NS092803Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Clearance Pathways in the CNS in Aging and HIV
    NIH/NIA R01AG043384May 1, 2012 - Apr 30, 2017
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Evaluation of Biochemical and Epigenetic Measures of Peripheral Brain-Derived Neurotrophic Factor (BDNF) as a Biomarker in Huntington's Disease Patients. Front Mol Neurosci. 2019; 12:335. Gutierrez A, Corey-Bloom J, Thomas EA, Desplats P. PMID: 32038165.
      View in: PubMed   Mentions:
    2. Perfect timing: circadian rhythms, sleep, and immunity - an NIH workshop summary. JCI Insight. 2020 01 16; 5(1). Haspel JA, Anafi R, Brown MK, Cermakian N, Depner C, Desplats P, Gelman AE, Haack M, Jelic S, Kim BS, Laposky AD, Lee YC, Mongodin E, Prather AA, Prendergast BJ, Reardon C, Shaw AC, Sengupta S, Szentirmai É, Thakkar M, Walker WE, Solt LA. PMID: 31941836.
      View in: PubMed   Mentions: 6     Fields:    
    3. Microglial memory of early life stress and inflammation: Susceptibility to neurodegeneration in adulthood. Neurosci Biobehav Rev. 2019 Nov 05. Desplats P, Gutierrez AM, Antonelli MC, Frasch MG. PMID: 31703966.
      View in: PubMed   Mentions: 3     Fields:    
    4. Alterations in Striatal microRNA-mRNA Networks Contribute to Neuroinflammation in Multiple System Atrophy. Mol Neurobiol. 2019 Oct; 56(10):7003-7021. Kim T, Valera E, Desplats P. PMID: 30968343.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. DNA methylation changes associated with Parkinson's disease progression: outcomes from the first longitudinal genome-wide methylation analysis in blood. Epigenetics. 2019 04; 14(4):365-382. Henderson-Smith A, Fisch KM, Hua J, Liu G, Ricciardelli E, Jepsen K, Huentelman M, Stalberg G, Edland SD, Scherzer CR, Dunckley T, Desplats P. PMID: 30871403.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    6. Alterations in brain TREM2 and Amyloid-ß levels are associated with neurocognitive impairment in HIV-infected persons on antiretroviral therapy. J Neurochem. 2018 12; 147(6):784-802. Fields JA, Spencer B, Swinton M, Qvale EM, Marquine MJ, Alexeeva A, Gough S, Soontornniyomkij B, Valera E, Masliah E, Achim CL, Desplats P. PMID: 30152135.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    7. Non-invasive biomarkers of fetal brain development reflecting prenatal stress: An integrative multi-scale multi-species perspective on data collection and analysis. Neurosci Biobehav Rev. 2018 May 30. Frasch MG, Lobmaier SM, Stampalija T, Desplats P, Pallarés ME, Pastor V, Brocco MA, Wu HT, Schulkin J, Herry CL, Seely AJE, Metz GAS, Louzoun Y, Antonelli MC. PMID: 29859198.
      View in: PubMed   Mentions: 4     Fields:    
    8. Identification of Insulin Receptor Splice Variant B in Neurons by in situ Detection in Human Brain Samples. Sci Rep. 2018 03 06; 8(1):4070. Spencer B, Rank L, Metcalf J, Desplats P. PMID: 29511314.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. MicroRNA-101 Modulates Autophagy and Oligodendroglial Alpha-Synuclein Accumulation in Multiple System Atrophy. Front Mol Neurosci. 2017; 10:329. Valera E, Spencer B, Mott J, Trejo M, Adame A, Mante M, Rockenstein E, Troncoso JC, Beach TG, Masliah E, Desplats P. PMID: 29089869.
      View in: PubMed   Mentions:
    10. Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy. Acta Neuropathol Commun. 2017 01 05; 5(1):2. Valera E, Spencer B, Fields JA, Trinh I, Adame A, Mante M, Rockenstein E, Desplats P, Masliah E. PMID: 28057080.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    11. Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1. Alzheimers Dement. 2017 Jun; 13(6):689-700. Cronin P, McCarthy MJ, Lim ASP, Salmon DP, Galasko D, Masliah E, De Jager PL, Bennett DA, Desplats P. PMID: 27883893.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    12. A de novo compound targeting a-synuclein improves deficits in models of Parkinson's disease. Brain. 2016 12; 139(Pt 12):3217-3236. Wrasidlo W, Tsigelny IF, Price DL, Dutta G, Rockenstein E, Schwarz TC, Ledolter K, Bonhaus D, Paulino A, Eleuteri S, Skjevik ÅA, Kouznetsova VL, Spencer B, Desplats P, Gonzalez-Ruelas T, Trejo-Morales M, Overk CR, Winter S, Zhu C, Chesselet MF, Meier D, Moessler H, Konrat R, Masliah E. PMID: 27679481.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    13. Reducing Endogenous a-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model. J Neurosci. 2016 07 27; 36(30):7971-84. Spencer B, Desplats PA, Overk CR, Valera-Martin E, Rissman RA, Wu C, Mante M, Adame A, Florio J, Rockenstein E, Masliah E. PMID: 27466341.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    14. Neuropeptide Treatment with Cerebrolysin Enhances the Survival of Grafted Neural Stem Cell in an a-Synuclein Transgenic Model of Parkinson's Disease. J Exp Neurosci. 2015; 9(Suppl 2):131-40. Rockenstein E, Desplats P, Ubhi K, Mante M, Florio J, Adame A, Winter S, Brandstaetter H, Meier D, Moessler H, Masliah E. PMID: 27429559.
      View in: PubMed   Mentions:
    15. Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity. J Neuroinflammation. 2016 05 24; 13(1):120. Fields JA, Overk C, Adame A, Florio J, Mante M, Pineda A, Desplats P, Rockenstein E, Achim C, Masliah E. PMID: 27220536.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    16. a-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease. Hum Mol Genet. 2016 Mar 15; 25(6):1100-15. Spencer B, Kim C, Gonzalez T, Bisquertt A, Patrick C, Rockenstein E, Adame A, Lee SJ, Desplats P, Masliah E. PMID: 26740557.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    17. Hypoestoxide reduces neuroinflammation and a-synuclein accumulation in a mouse model of Parkinson's disease. J Neuroinflammation. 2015 Dec 18; 12:236. Kim C, Ojo-Amaize E, Spencer B, Rockenstein E, Mante M, Desplats P, Wrasidlo W, Adame A, Nchekwube E, Oyemade O, Okogun J, Chan M, Cottam H, Masliah E. PMID: 26683203.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    18. Neuro-peptide treatment with Cerebrolysin improves the survival of neural stem cell grafts in an APP transgenic model of Alzheimer disease. Stem Cell Res. 2015 Jul; 15(1):54-67. Rockenstein E, Desplats P, Ubhi K, Mante M, Florio J, Adame A, Winter S, Brandstaetter H, Meier D, Masliah E. PMID: 26209890.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    19. Perinatal programming of neurodevelopment: epigenetic mechanisms and the prenatal shaping of the brain. Adv Neurobiol. 2015; 10:335-61. Desplats PA. PMID: 25287548.
      View in: PubMed   Mentions: 7     Fields:    
    20. Epigenetic alterations in the brain associated with HIV-1 infection and methamphetamine dependence. PLoS One. 2014; 9(7):e102555. Desplats P, Dumaop W, Cronin P, Gianella S, Woods S, Letendre S, Smith D, Masliah E, Grant I. PMID: 25054922.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    21. ESCRT-mediated uptake and degradation of brain-targeted a-synuclein single chain antibody attenuates neuronal degeneration in vivo. Mol Ther. 2014 Oct; 22(10):1753-67. Spencer B, Emadi S, Desplats P, Eleuteri S, Michael S, Kosberg K, Shen J, Rockenstein E, Patrick C, Adame A, Gonzalez T, Sierks M, Masliah E. PMID: 25008355.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    22. Hippocampal neuronal cells that accumulate a-synuclein fragments are more vulnerable to Aß oligomer toxicity via mGluR5--implications for dementia with Lewy bodies. Mol Neurodegener. 2014 May 19; 9:18. Overk CR, Cartier A, Shaked G, Rockenstein E, Ubhi K, Spencer B, Price DL, Patrick C, Desplats P, Masliah E. PMID: 24885390.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    23. A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis. J Biol Chem. 2014 Jun 20; 289(25):17917-31. Spencer B, Verma I, Desplats P, Morvinski D, Rockenstein E, Adame A, Masliah E. PMID: 24825898.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    24. Structural diversity of Alzheimer's disease amyloid-ß dimers and their role in oligomerization and fibril formation. J Alzheimers Dis. 2014; 39(3):583-600. Tsigelny IF, Sharikov Y, Kouznetsova VL, Greenberg JP, Wrasidlo W, Gonzalez T, Desplats P, Michael SE, Trejo-Morales M, Overk CR, Masliah E. PMID: 24240640.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    25. Distinctive patterns of DNA methylation associated with Parkinson disease: identification of concordant epigenetic changes in brain and peripheral blood leukocytes. Epigenetics. 2013 Oct; 8(10):1030-8. Masliah E, Dumaop W, Galasko D, Desplats P. PMID: 23907097.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    26. TOM40 mediates mitochondrial dysfunction induced by a-synuclein accumulation in Parkinson's disease. PLoS One. 2013; 8(4):e62277. Bender A, Desplats P, Spencer B, Rockenstein E, Adame A, Elstner M, Laub C, Mueller S, Koob AO, Mante M, Pham E, Klopstock T, Masliah E. PMID: 23626796.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    27. Molecular and pathologic insights from latent HIV-1 infection in the human brain. Neurology. 2013 Apr 09; 80(15):1415-23. Desplats P, Dumaop W, Smith D, Adame A, Everall I, Letendre S, Ellis R, Cherner M, Grant I, Masliah E. PMID: 23486877.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    28. Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease. Mol Neurodegener. 2012 Sep 28; 7:49. Desplats P, Patel P, Kosberg K, Mante M, Patrick C, Rockenstein E, Fujita M, Hashimoto M, Masliah E. PMID: 23017109.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    29. Antibody-aided clearance of extracellular a-synuclein prevents cell-to-cell aggregate transmission. J Neurosci. 2012 Sep 26; 32(39):13454-69. Bae EJ, Lee HJ, Rockenstein E, Ho DH, Park EB, Yang NY, Desplats P, Masliah E, Lee SJ. PMID: 23015436.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    30. a-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1. J Biol Chem. 2012 Sep 14; 287(38):31691-702. Desplats P, Spencer B, Crews L, Pathel P, Morvinski-Friedmann D, Kosberg K, Roberts S, Patrick C, Winner B, Winkler J, Masliah E. PMID: 22833673.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    31. In vivo alterations in calcium buffering capacity in transgenic mouse model of synucleinopathy. J Neurosci. 2012 Jul 18; 32(29):9992-8. Reznichenko L, Cheng Q, Nizar K, Gratiy SL, Saisan PA, Rockenstein EM, González T, Patrick C, Spencer B, Desplats P, Dale AM, Devor A, Masliah E. PMID: 22815513.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    32. Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease. Hum Mol Genet. 2012 Jul 15; 21(14):3097-111. Tang B, Becanovic K, Desplats PA, Spencer B, Hill AM, Connolly C, Masliah E, Leavitt BR, Thomas EA. PMID: 22492998.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    33. Role of a-synuclein penetration into the membrane in the mechanisms of oligomer pore formation. FEBS J. 2012 Mar; 279(6):1000-13. Tsigelny IF, Sharikov Y, Wrasidlo W, Gonzalez T, Desplats PA, Crews L, Spencer B, Masliah E. PMID: 22251432.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    34. Cell-to-cell transmission of a-synuclein aggregates. Methods Mol Biol. 2012; 849:347-59. Lee SJ, Desplats P, Lee HJ, Spencer B, Masliah E. PMID: 22528101.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    35. Increased CDK5 expression in HIV encephalitis contributes to neurodegeneration via tau phosphorylation and is reversed with Roscovitine. Am J Pathol. 2011 Apr; 178(4):1646-61. Patrick C, Crews L, Desplats P, Dumaop W, Rockenstein E, Achim CL, Everall IP, Masliah E. PMID: 21435449.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    36. In vivo demonstration that alpha-synuclein oligomers are toxic. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4194-9. Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, Pham E, Masliah E, Gage FH, Riek R. PMID: 21325059.
      View in: PubMed   Mentions: 385     Fields:    Translation:AnimalsCells
    37. Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases. J Biol Chem. 2011 Mar 18; 286(11):9031-7. Desplats P, Spencer B, Coffee E, Patel P, Michael S, Patrick C, Adame A, Rockenstein E, Masliah E. PMID: 21296890.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    38. Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity. PLoS One. 2010 Nov 16; 5(11):e14020. Price DL, Rockenstein E, Ubhi K, Phung V, MacLean-Lewis N, Askay D, Cartier A, Spencer B, Patrick C, Desplats P, Ellisman MH, Masliah E. PMID: 21103359.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    39. Cell-to-cell transmission of non-prion protein aggregates. Nat Rev Neurol. 2010 12; 6(12):702-6. Lee SJ, Desplats P, Sigurdson C, Tsigelny I, Masliah E. PMID: 21045796.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    40. Cerebellar lipid differences between R6/1 transgenic mice and humans with Huntington's disease. J Neurochem. 2010 Nov; 115(3):748-58. Denny CA, Desplats PA, Thomas EA, Seyfried TN. PMID: 20731757.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    41. Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy. PLoS One. 2010 Feb 19; 5(2):e9313. Crews L, Spencer B, Desplats P, Patrick C, Paulino A, Rockenstein E, Hansen L, Adame A, Galasko D, Masliah E. PMID: 20174468.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansAnimalsCells
    42. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):13010-5. Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L, Spencer B, Masliah E, Lee SJ. PMID: 19651612.
      View in: PubMed   Mentions: 553     Fields:    Translation:HumansAnimalsCells
    43. Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model. Exp Neurol. 2009 Oct; 219(2):543-52. Winner B, Desplats P, Hagl C, Klucken J, Aigner R, Ploetz S, Laemke J, Karl A, Aigner L, Masliah E, Buerger E, Winkler J. PMID: 19619535.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    44. The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15564-9. Thomas EA, Coppola G, Desplats PA, Tang B, Soragni E, Burnett R, Gao F, Fitzgerald KM, Borok JF, Herman D, Geschwind DH, Gottesfeld JM. PMID: 18829438.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    45. Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases. PLoS One. 2008 Sep 04; 3(9):e3135. Tsigelny IF, Crews L, Desplats P, Shaked GM, Sharikov Y, Mizuno H, Spencer B, Rockenstein E, Trejo M, Platoshyn O, Yuan JX, Masliah E. PMID: 18769546.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    46. Functional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's disease. Neurobiol Dis. 2008 Sep; 31(3):298-308. Desplats PA, Lambert JR, Thomas EA. PMID: 18595722.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    47. Alpha-synuclein alters Notch-1 expression and neurogenesis in mouse embryonic stem cells and in the hippocampus of transgenic mice. J Neurosci. 2008 Apr 16; 28(16):4250-60. Crews L, Mizuno H, Desplats P, Rockenstein E, Adame A, Patrick C, Winner B, Winkler J, Masliah E. PMID: 18417705.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    48. Glycolipid and ganglioside metabolism imbalances in Huntington's disease. Neurobiol Dis. 2007 Sep; 27(3):265-77. Desplats PA, Denny CA, Kass KE, Gilmartin T, Head SR, Sutcliffe JG, Seyfried TN, Thomas EA. PMID: 17600724.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    49. Selective deficits in the expression of striatal-enriched mRNAs in Huntington's disease. J Neurochem. 2006 Feb; 96(3):743-57. Desplats PA, Kass KE, Gilmartin T, Stanwood GD, Woodward EL, Head SR, Sutcliffe JG, Thomas EA. PMID: 16405510.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    50. Sucrose may play an additional role to that of an osmolyte in Synechocystis sp. PCC 6803 salt-shocked cells. Plant Physiol Biochem. 2005 Feb; 43(2):133-8. Desplats P, Folco E, Salerno GL. PMID: 15820660.
      View in: PubMed   Mentions:
    51. Chemotaxis of Silicibacter sp. strain TM1040 toward dinoflagellate products. Appl Environ Microbiol. 2004 Aug; 70(8):4692-701. Miller TR, Hnilicka K, Dziedzic A, Desplats P, Belas R. PMID: 15294804.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    52. Sucrose-phosphate synthase from Synechocystis sp. strain PCC 6803: identification of the spsA gene and characterization of the enzyme expressed in Escherichia coli. J Bacteriol. 1998 Dec; 180(24):6776-9. Curatti L, Folco E, Desplats P, Abratti G, Limones V, Herrera-Estrella L, Salerno G. PMID: 9852031.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    Paula's Networks
    Concepts (303)
    Derived automatically from this person's publications.
    _
    Co-Authors (41)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _