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    Christopher Putnam

    TitleAssociate Adjunct Professor
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0669
    CA La Jolla 92093
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Putnam C, Kolodner RD. Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiae. Genetics. 2017 Jul; 206(3):1187-1225. PMID: 28684602.
        View in: PubMed
      2. Albuquerque CP, Wang G, Lee NS, Kolodner RD, Putnam C, Zhou H. Correction: Distinct SUMO Ligases Cooperate with Esc2 and Slx5 to Suppress Duplication-Mediated Genome Rearrangements. PLoS Genet. 2016 Aug; 12(8):e1006302. PMID: 27579875.
        View in: PubMed
      3. Putnam C. Guinier peak analysis for visual and automated inspection of small-angle X-ray scattering data. J Appl Crystallogr. 2016 Oct 01; 49(Pt 5):1412-1419. PMID: 27738411.
        View in: PubMed
      4. Putnam C, Srivatsan A, Nene RV, Martinez SL, Clotfelter SP, Bell SN, Somach SB, de Souza JE, Fonseca AF, de Souza SJ, Kolodner RD. A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers. Nat Commun. 2016 Apr 13; 7:11256. PMID: 27071721; PMCID: PMC4833866.
      5. Putnam C. Evolution of the methyl directed mismatch repair system in Escherichia coli. DNA Repair (Amst). 2016 Feb; 38:32-41. PMID: 26698649; PMCID: PMC4740232 [Available on 02/01/17].
      6. Goellner EM, Putnam C, Kolodner RD. Exonuclease 1-dependent and independent mismatch repair. DNA Repair (Amst). 2015 Aug; 32:24-32. PMID: 25956862; PMCID: PMC4522362.
      7. Goellner EM, Smith CE, Campbell CS, Hombauer H, Desai A, Putnam C, Kolodner RD. PCNA and Msh2-Msh6 activate an Mlh1-Pms1 endonuclease pathway required for Exo1-independent mismatch repair. Mol Cell. 2014 Jul 17; 55(2):291-304. PMID: 24981171; PMCID: PMC4113420.
      8. Campbell CS, Hombauer H, Srivatsan A, Bowen N, Gries K, Desai A, Putnam C, Kolodner RD. Mlh2 is an accessory factor for DNA mismatch repair in Saccharomyces cerevisiae. PLoS Genet. 2014 May; 10(5):e1004327. PMID: 24811092; PMCID: PMC4014439.
      9. Putnam C, Pallis K, Hayes TK, Kolodner RD. DNA repair pathway selection caused by defects in TEL1, SAE2, and de novo telomere addition generates specific chromosomal rearrangement signatures. PLoS Genet. 2014 Apr; 10(4):e1004277. PMID: 24699249; PMCID: PMC3974649.
      10. Allen-Soltero S, Martinez SL, Putnam C, Kolodner RD. A saccharomyces cerevisiae RNase H2 interaction network functions to suppress genome instability. Mol Cell Biol. 2014 Apr; 34(8):1521-34. PMID: 24550002; PMCID: PMC3993591.
      11. Smith CE, Mendillo ML, Bowen N, Hombauer H, Campbell CS, Desai A, Putnam C, Kolodner RD. Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway. PLoS Genet. 2013 Oct; 9(10):e1003869. PMID: 24204293; PMCID: PMC3814310.
      12. Hura GL, Tsai CL, Claridge SA, Mendillo ML, Smith JM, Williams GJ, Mastroianni AJ, Alivisatos AP, Putnam C, Kolodner RD, Tainer JA. DNA conformations in mismatch repair probed in solution by X-ray scattering from gold nanocrystals. Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43):17308-13. PMID: 24101514; PMCID: PMC3808630.
      13. Albuquerque CP, Wang G, Lee NS, Kolodner RD, Putnam C, Zhou H. Distinct SUMO ligases cooperate with Esc2 and Slx5 to suppress duplication-mediated genome rearrangements. PLoS Genet. 2013; 9(8):e1003670. PMID: 23935535; PMCID: PMC3731205.
      14. Putnam C, Allen-Soltero SR, Martinez SL, Chan JE, Hayes TK, Kolodner RD. Bioinformatic identification of genes suppressing genome instability. Proc Natl Acad Sci U S A. 2012 Nov 20; 109(47):E3251-9. PMID: 23129647; PMCID: PMC3511103.
      15. Hargreaves VV, Putnam C, Kolodner RD. Engineered disulfide-forming amino acid substitutions interfere with a conformational change in the mismatch recognition complex Msh2-Msh6 required for mismatch repair. J Biol Chem. 2012 Nov 30; 287(49):41232-44. PMID: 23045530; PMCID: PMC3510822.
      16. Broderick L, Gandhi C, Mueller JL, Putnam C, Shayan K, Giclas PC, Peterson KS, Aceves SS, Sheets RM, Peterson BM, Newbury RO, Hoffman HM, Bastian JF. Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis. J Clin Immunol. 2013 Jan; 33(1):162-71. PMID: 22926405; PMCID: PMC3540165.
      17. Hombauer H, Srivatsan A, Putnam C, Kolodner RD. Mismatch repair, but not heteroduplex rejection, is temporally coupled to DNA replication. Science. 2011 Dec 23; 334(6063):1713-6. PMID: 22194578; PMCID: PMC3806717.
      18. Zimmermann C, Chymkowitch P, Eldholm V, Putnam C, Lindvall JM, Omerzu M, Bjørås M, Kolodner RD, Enserink JM. A chemical-genetic screen to unravel the genetic network of CDC28/CDK1 links ubiquitin and Rad6-Bre1 to cell cycle progression. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18748-53. PMID: 22042866; PMCID: PMC3219101.
      19. Kolodner RD, Cleveland DW, Putnam C. Cancer. Aneuploidy drives a mutator phenotype in cancer. Science. 2011 Aug 19; 333(6045):942-3. PMID: 21852477; PMCID: PMC3806716.
      20. Putnam C, Kolodner RD. Determination of gross chromosomal rearrangement rates. Cold Spring Harb Protoc. 2010 Sep 01; 2010(9):pdb.prot5492. PMID: 20810639; PMCID: PMC3047512.
      21. Putnam C, Hayes TK, Kolodner RD. Post-replication repair suppresses duplication-mediated genome instability. PLoS Genet. 2010 May 06; 6(5):e1000933. PMID: 20463880; PMCID: PMC2865514.
      22. Dowen JM, Putnam C, Kolodner RD. Functional studies and homology modeling of Msh2-Msh3 predict that mispair recognition involves DNA bending and strand separation. Mol Cell Biol. 2010 Jul; 30(13):3321-8. PMID: 20421420; PMCID: PMC2897569.
      23. Mendillo ML, Putnam C, Mo AO, Jamison JW, Li S, Woods VL, Kolodner RD. Probing DNA- and ATP-mediated conformational changes in the MutS family of mispair recognition proteins using deuterium exchange mass spectrometry. J Biol Chem. 2010 Apr 23; 285(17):13170-82. PMID: 20181951; PMCID: PMC2857143.
      24. Mendillo ML, Hargreaves VV, Jamison JW, Mo AO, Li S, Putnam C, Woods VL, Kolodner RD. A conserved MutS homolog connector domain interface interacts with MutL homologs. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22223-8. PMID: 20080788; PMCID: PMC2796910.
      25. Putnam C, Hayes TK, Kolodner RD. Specific pathways prevent duplication-mediated genome rearrangements. Nature. 2009 Aug 20; 460(7258):984-9. PMID: 19641493; PMCID: PMC2785216.
      26. Brydges SD, Mueller JL, McGeough MD, Pena CA, Misaghi A, Gandhi C, Putnam C, Boyle DL, Firestein GS, Horner AA, Soroosh P, Watford WT, O'Shea JJ, Kastner DL, Hoffman HM. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity. 2009 Jun 19; 30(6):875-87. PMID: 19501000; PMCID: PMC2759865.
      27. Putnam C, Jaehnig EJ, Kolodner RD. Perspectives on the DNA damage and replication checkpoint responses in Saccharomyces cerevisiae. DNA Repair (Amst). 2009 Sep 02; 8(9):974-82. PMID: 19477695; PMCID: PMC2725198.
      28. Putnam C, Hammel M, Hura GL, Tainer JA. X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution. Q Rev Biophys. 2007 Aug; 40(3):191-285. PMID: 18078545.
        View in: PubMed
      29. Kolodner RD, Mendillo ML, Putnam C. Coupling distant sites in DNA during DNA mismatch repair. Proc Natl Acad Sci U S A. 2007 Aug 07; 104(32):12953-4. PMID: 17664420; PMCID: PMC1941800.
      30. Shell SS, Putnam C, Kolodner RD. Chimeric Saccharomyces cerevisiae Msh6 protein with an Msh3 mispair-binding domain combines properties of both proteins. Proc Natl Acad Sci U S A. 2007 Jun 26; 104(26):10956-61. PMID: 17573527; PMCID: PMC1904149.
      31. Shell SS, Putnam C, Kolodner RD. The N terminus of Saccharomyces cerevisiae Msh6 is an unstructured tether to PCNA. Mol Cell. 2007 May 25; 26(4):565-78. PMID: 17531814; PMCID: PMC2001284.
      32. Mendillo ML, Putnam C, Kolodner RD. Escherichia coli MutS tetramerization domain structure reveals that stable dimers but not tetramers are essential for DNA mismatch repair in vivo. J Biol Chem. 2007 Jun 01; 282(22):16345-54. PMID: 17426027.
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      33. Aksentijevich I, Putnam C, Remmers EF, Mueller JL, Le J, Kolodner RD, Moak Z, Chuang M, Austin F, Goldbach-Mansky R, Hoffman HM, Kastner DL. The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin model. Arthritis Rheum. 2007 Apr; 56(4):1273-1285. PMID: 17393462; PMCID: PMC4321998.
      34. Pennaneach V, Putnam C, Kolodner RD. Chromosome healing by de novo telomere addition in Saccharomyces cerevisiae. Mol Microbiol. 2006 Mar; 59(5):1357-68. PMID: 16468981.
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      35. Schmidt KH, Pennaneach V, Putnam C, Kolodner RD. Analysis of gross-chromosomal rearrangements in Saccharomyces cerevisiae. Methods Enzymol. 2006; 409:462-76. PMID: 16793418.
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      36. Putnam C, Tainer JA. Protein mimicry of DNA and pathway regulation. DNA Repair (Amst). 2005 Dec 08; 4(12):1410-20. PMID: 16226493.
        View in: PubMed
      37. Putnam C, Pennaneach V, Kolodner RD. Saccharomyces cerevisiae as a model system to define the chromosomal instability phenotype. Mol Cell Biol. 2005 Aug; 25(16):7226-38. PMID: 16055731; PMCID: PMC1190249.
      38. Wang Y, Putnam C, Kane MF, Zhang W, Edelmann L, Russell R, Carrión DV, Chin L, Kucherlapati R, Kolodner RD, Edelmann W. Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice. Nat Genet. 2005 Jul; 37(7):750-5. PMID: 15965476.
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      39. Putnam C, Pennaneach V, Kolodner RD. Chromosome healing through terminal deletions generated by de novo telomere additions in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2004 Sep 07; 101(36):13262-7. PMID: 15328403; PMCID: PMC516557.
      40. Barondeau DP, Putnam C, Kassmann CJ, Tainer JA, Getzoff ED. Mechanism and energetics of green fluorescent protein chromophore synthesis revealed by trapped intermediate structures. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12111-6. PMID: 14523232; PMCID: PMC218721.
      41. Kolodner RD, Putnam C, Myung K. Maintenance of genome stability in Saccharomyces cerevisiae. Science. 2002 Jul 26; 297(5581):552-7. PMID: 12142524.
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      42. Balicki D, Putnam C, Scaria PV, Beutler E. Structure and function correlation in histone H2A peptide-mediated gene transfer. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7467-71. PMID: 12032306; PMCID: PMC124254.
      43. Hopfner KP, Putnam C, Tainer JA. DNA double-strand break repair from head to tail. Curr Opin Struct Biol. 2002 Feb; 12(1):115-22. PMID: 11839498.
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      44. Putnam C, Clancy SB, Tsuruta H, Gonzalez S, Wetmur JG, Tainer JA. Structure and mechanism of the RuvB Holliday junction branch migration motor. J Mol Biol. 2001 Aug 10; 311(2):297-310. PMID: 11478862.
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      45. Hosfield DJ, Daniels DS, Mol CD, Putnam C, Parikh SS, Tainer JA. DNA damage recognition and repair pathway coordination revealed by the structural biochemistry of DNA repair enzymes. Prog Nucleic Acid Res Mol Biol. 2001; 68:315-47. PMID: 11554309.
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      46. Parikh SS, Putnam C, Tainer JA. Lessons learned from structural results on uracil-DNA glycosylase. Mutat Res. 2000 Aug 30; 460(3-4):183-99. PMID: 10946228.
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      47. Putnam C, Arvai AS, Bourne Y, Tainer JA. Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism. J Mol Biol. 2000 Feb 11; 296(1):295-309. PMID: 10656833.
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      48. Putnam C, Tainer JA. The food of sweet and bitter fancy. Nat Struct Biol. 2000 Jan; 7(1):17-8. PMID: 10625418.
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      49. Han S, Craig JA, Putnam C, Carozzi NB, Tainer JA. Evolution and mechanism from structures of an ADP-ribosylating toxin and NAD complex. Nat Struct Biol. 1999 Oct; 6(10):932-6. PMID: 10504727.
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      50. Shroyer MJ, Bennett SE, Putnam C, Tainer JA, Mosbaugh DW. Mutation of an active site residue in Escherichia coli uracil-DNA glycosylase: effect on DNA binding, uracil inhibition and catalysis. Biochemistry. 1999 Apr 13; 38(15):4834-45. PMID: 10200172.
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      51. Putnam C, Shroyer MJ, Lundquist AJ, Mol CD, Arvai AS, Mosbaugh DW, Tainer JA. Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase. J Mol Biol. 1999 Mar 26; 287(2):331-46. PMID: 10080896.
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      52. Mol CD, Parikh SS, Putnam C, Lo TP, Tainer JA. DNA repair mechanisms for the recognition and removal of damaged DNA bases. Annu Rev Biophys Biomol Struct. 1999; 28:101-28. PMID: 10410797.
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      53. Wilcox SK, Putnam C, Sastry M, Blankenship J, Chazin WJ, McRee DE, Goodin DB. Rational design of a functional metalloenzyme: introduction of a site for manganese binding and oxidation into a heme peroxidase. Biochemistry. 1998 Dec 01; 37(48):16853-62. PMID: 9836578.
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      54. Putnam C, Copenhaver GP, Denton ML, Pikaard CS. The RNA polymerase I transactivator upstream binding factor requires its dimerization domain and high-mobility-group (HMG) box 1 to bend, wrap, and positively supercoil enhancer DNA. Mol Cell Biol. 1994 Oct; 14(10):6476-88. PMID: 7935371; PMCID: PMC359177.
      55. Copenhaver GP, Putnam C, Denton ML, Pikaard CS. The RNA polymerase I transcription factor UBF is a sequence-tolerant HMG-box protein that can recognize structured nucleic acids. Nucleic Acids Res. 1994 Jul 11; 22(13):2651-7. PMID: 8041627; PMCID: PMC308223.
      56. Putnam C, Pikaard CS. Cooperative binding of the Xenopus RNA polymerase I transcription factor xUBF to repetitive ribosomal gene enhancers. Mol Cell Biol. 1992 Nov; 12(11):4970-80. PMID: 1406673; PMCID: PMC360429.
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