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Mana Parast

TitleProfessor In Residence
InstitutionUniversity of California San Diego
DepartmentPathology
Address9500 Gilman Drive #0695
La Jolla CA 92093
Phone858-534-8631
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    Collapse Biography 
    Collapse Education and Training
    University of Rochester, Rochester, NYB.S.05/1994Microbiology
    University of Virginia, Charlottesville, VAPh.D.08/2001Cell Biology
    University of Virginia, Charlottesville, VAM.D.01/2002Medicine
    Emory University, Atlanta, GAResidency06/2005Anatomic Pathology
    Brigham and Women's Hospital, Boston, MAFellowship06/2006Women's and Perinatal Pathology
    Brigham and Women's Hospital, Boston, MAPostdoctoral training12/2007Placental Biology

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Genome integrity and proteotoxic stress in extravillous trophoblast differentiation and function
    NIH/NICHD R21HD094618Aug 1, 2018 - Jul 31, 2020
    Role: Principal Investigator
    Human Trophoblast Stem Cells: the In Vivo Niche and Relationship to Pluripotent Stem Cells
    NIH/NICHD R01HD089537Mar 15, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Endocervical Trophoblast-derived Biomarkers Across Gestation
    NIH/NICHD R21HD089683Sep 20, 2016 - Aug 31, 2018
    Role: Principal Investigator
    Modeling human trophoblast stem cells using iPS cells derived from molar placenta
    NIH/NICHD R21HD073673Jul 15, 2013 - Jun 30, 2015
    Role: Principal Investigator
    Sirt1-PPARgamma signaling in placental development and fetal growth disorders
    NIH/NICHD R01HD071100Apr 1, 2012 - Mar 31, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Do JP, Cao KJ, Wei S, Laurent LC, Parast MM, Yang J. Identification of Patients with Preeclampsia by Measuring Fluorescence of an Amyloid-Binding Aryl Cyano Amide in Human Urine Samples. Anal Chem. 2018 Nov 16. PMID: 30444965.
      View in: PubMed
    2. Parast MM. Kurt Benirschke: In Memoriam. Placenta. 2018 Nov; 71:iv-vi. PMID: 30396517.
      View in: PubMed
    3. Palmsten K, Nelson KK, Laurent LC, Park S, Chambers CD, Parast MM. Subclinical and clinical chorioamnionitis, fetal vasculitis, and risk for preterm birth: A cohort study. Placenta. 2018 Jul; 67:54-60. PMID: 29941174.
      View in: PubMed
    4. Pham J, Arul Nambi Rajan K, Li P, Parast MM. The role of Sirtuin1-PPAR? axis in placental development and function. J Mol Endocrinol. 2018 May; 60(4):R201-R212. PMID: 29467141.
      View in: PubMed
    5. Soncin F, Khater M, To C, Pizzo D, Farah O, Wakeland A, Arul Nambi Rajan K, Nelson KK, Chang CW, Moretto-Zita M, Natale DR, Laurent LC, Parast MM. Comparative analysis of mouse and human placentae across gestation reveals species-specific regulators of placental development. Development. 2018 01 29; 145(2). PMID: 29361559.
      View in: PubMed
    6. Chang CW, Wakeland AK, Parast MM. Trophoblast lineage specification, differentiation and their regulation by oxygen tension. J Endocrinol. 2018 Jan; 236(1):R43-R56. PMID: 29259074.
      View in: PubMed
    7. Arul Nambi Rajan K, Khater M, Soncin F, Pizzo D, Moretto-Zita M, Pham J, Stus O, Iyer P, Tache V, Laurent LC, Parast MM. Sirtuin1 is required for proper trophoblast differentiation and placental development in mice. Placenta. 2018 Feb; 62:1-8. PMID: 29405961.
      View in: PubMed
    8. Wakeland AK, Soncin F, Moretto-Zita M, Chang CW, Horii M, Pizzo D, Nelson KK, Laurent LC, Parast MM. Hypoxia Directs Human Extravillous Trophoblast Differentiation in a Hypoxia-Inducible Factor-Dependent Manner. Am J Pathol. 2017 Apr; 187(4):767-780. PMID: 28167044.
      View in: PubMed
    9. Chang CW, Parast MM. Human trophoblast stem cells: Real or not real? Placenta. 2017 12; 60 Suppl 1:S57-S60. PMID: 28087122.
      View in: PubMed
    10. Szabo L, Morey R, Palpant NJ, Wang PL, Afari N, Jiang C, Parast MM, Murry CE, Laurent LC, Salzman J. Erratum to: Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Genome Biol. 2016 12 19; 17(1):263. PMID: 27993159.
      View in: PubMed
    11. Qiao L, Wattez JS, Lee S, Guo Z, Schaack J, Hay WW, Zita MM, Parast M, Shao J. Knockout maternal adiponectin increases fetal growth in mice: potential role for trophoblast IGFBP-1. Diabetologia. 2016 11; 59(11):2417-2425. PMID: 27495989.
      View in: PubMed
    12. Horii M, Li Y, Wakeland AK, Pizzo DP, Nelson KK, Sabatini K, Laurent LC, Liu Y, Parast MM. Human pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):E3882-91. PMID: 27325764; PMCID: PMC4941448 [Available on 01/05/17].
    13. Leon-Garcia SM, Roeder HA, Nelson KK, Liao X, Pizzo DP, Laurent LC, Parast MM, LaCoursiere DY. Maternal obesity and sex-specific differences in placental pathology. Placenta. 2016 Feb; 38:33-40. PMID: 26907380.
      View in: PubMed
    14. Moretto Zita M, Soncin F, Natale D, Pizzo D, Parast M. Gene Expression Profiling Reveals a Novel Regulatory Role for Sox21 Protein in Mouse Trophoblast Stem Cell Differentiation. J Biol Chem. 2015 Dec 11; 290(50):30152-62. PMID: 26491013; PMCID: PMC4705987 [Available on 12/11/16].
    15. Horii M, Moretto-Zita M, Nelson KK, Li Y, Parast MM. MTA3 regulates differentiation of human cytotrophoblast stem cells. Placenta. 2015 Sep; 36(9):974-80. PMID: 26198267; PMCID: PMC4554833.
    16. Gallego Romero I, Pavlovic BJ, Hernando-Herraez I, Zhou X, Ward MC, Banovich NE, Kagan CL, Burnett JE, Huang CH, Mitrano A, Chavarria CI, Friedrich Ben-Nun I, Li Y, Sabatini K, Leonardo TR, Parast M, Marques-Bonet T, Laurent LC, Loring JF, Gilad Y. A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics. Elife. 2015 Jun 23; 4:e07103. PMID: 26102527; PMCID: PMC4502404.
    17. Szabo L, Morey R, Palpant NJ, Wang PL, Afari N, Jiang C, Parast MM, Murry CE, Laurent LC, Salzman J. Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Genome Biol. 2015 Jun 16; 16:126. PMID: 26076956; PMCID: PMC4506483.
    18. Qiao L, Guo Z, Bosco C, Guidotti S, Wang Y, Wang M, Parast M, Schaack J, Hay WW, Moore TR, Shao J. Maternal High-Fat Feeding Increases Placental Lipoprotein Lipase Activity by Reducing SIRT1 Expression in Mice. Diabetes. 2015 Sep; 64(9):3111-20. PMID: 25948680; PMCID: PMC4542442.
    19. Garitaonandia I, Amir H, Boscolo FS, Wambua GK, Schultheisz HL, Sabatini K, Morey R, Waltz S, Wang YC, Tran H, Leonardo TR, Nazor K, Slavin I, Lynch C, Li Y, Coleman R, Gallego Romero I, Altun G, Reynolds D, Dalton S, Parast M, Loring JF, Laurent LC. Increased risk of genetic and epigenetic instability in human embryonic stem cells associated with specific culture conditions. PLoS One. 2015; 10(2):e0118307. PMID: 25714340.
      View in: PubMed
    20. Soncin F, Natale D, Parast MM. Signaling pathways in mouse and human trophoblast differentiation: a comparative review. Cell Mol Life Sci. 2015 Apr; 72(7):1291-302. PMID: 25430479; PMCID: PMC4366325.
    21. Roeder HA, Dejbakhsh SZ, Parast MM, Laurent LC, Woelkers DA. Abnormal uterine artery Doppler velocimetry predicts adverse outcomes in patients with abnormal analytes. Pregnancy Hypertens. 2014 Oct; 4(4):296-301. PMID: 26104819.
      View in: PubMed
    22. Li Y, Moretto-Zita M, Leon-Garcia S, Parast MM. p63 inhibits extravillous trophoblast migration and maintains cells in a cytotrophoblast stem cell-like state. Am J Pathol. 2014 Dec; 184(12):3332-43. PMID: 25307348; PMCID: PMC4258507.
    23. Chen C, Jiang P, Xue H, Peterson SE, Tran HT, McCann AE, Parast MM, Li S, Pleasure DE, Laurent LC, Loring JF, Liu Y, Deng W. Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells. Nat Commun. 2014 Jul 18; 5:4430. PMID: 25034944; PMCID: PMC4109022.
    24. Ali SR, Fong JJ, Carlin AF, Busch TD, Linden R, Angata T, Areschoug T, Parast M, Varki N, Murray J, Nizet V, Varki A. Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus. J Exp Med. 2014 Jun 02; 211(6):1231-42. PMID: 24799499; PMCID: PMC4042635.
    25. Li Y, Parast MM. BMP4 regulation of human trophoblast development. Int J Dev Biol. 2014; 58(2-4):239-46. PMID: 25023690.
      View in: PubMed
    26. Memon N, Bircsak KM, Archer F, Gibson CJ, Ohman-Strickland P, Weinberger BI, Parast MM, Vetrano AM, Aleksunes LM. Regional expression of the BCRP/ABCG2 transporter in term human placentas. Reprod Toxicol. 2014 Jan; 43:72-77. PMID: 24269555; PMCID: PMC3946646.
    27. Li Y, Moretto-Zita M, Soncin F, Wakeland A, Wolfe L, Leon-Garcia S, Pandian R, Pizzo D, Cui L, Nazor K, Loring JF, Crum CP, Laurent LC, Parast MM. BMP4-directed trophoblast differentiation of human embryonic stem cells is mediated through a ?Np63+ cytotrophoblast stem cell state. Development. 2013 Oct; 140(19):3965-76. PMID: 24004950; PMCID: PMC3775414.
    28. Tache V, Ciric A, Moretto-Zita M, Li Y, Peng J, Maltepe E, Milstone DS, Parast MM. Hypoxia and trophoblast differentiation: a key role for PPAR?. Stem Cells Dev. 2013 Nov 01; 22(21):2815-24. PMID: 23767827; PMCID: PMC3804243.
    29. Jones JC, Sabatini K, Liao X, Tran HT, Lynch CL, Morey RE, Glenn-Pratola V, Boscolo FS, Yang Q, Parast MM, Liu Y, Peterson SE, Laurent LC, Loring JF, Wang YC. Melanocytes derived from transgene-free human induced pluripotent stem cells. J Invest Dermatol. 2013 Aug; 133(8):2104-8. PMID: 23514962; PMCID: PMC3714355.
    30. Quinn KH, Parast MM. Decidual regulatory T cells in placental pathology and pregnancy complications. Am J Reprod Immunol. 2013 Jun; 69(6):533-8. PMID: 23384284.
      View in: PubMed
    31. Nazor KL, Altun G, Lynch C, Tran H, Harness JV, Slavin I, Garitaonandia I, Müller FJ, Wang YC, Boscolo FS, Fakunle E, Dumevska B, Lee S, Park HS, Olee T, D'Lima DD, Semechkin R, Parast MM, Galat V, Laslett AL, Schmidt U, Keirstead HS, Loring JF, Laurent LC. Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives. Cell Stem Cell. 2012 May 04; 10(5):620-34. PMID: 22560082; PMCID: PMC3348513.
    32. Wang W, Feng L, Zhang H, Hachy S, Satohisa S, Laurent LC, Parast M, Zheng J, Chen DB. Preeclampsia up-regulates angiogenesis-associated microRNA (i.e., miR-17, -20a, and -20b) that target ephrin-B2 and EPHB4 in human placenta. J Clin Endocrinol Metab. 2012 Jun; 97(6):E1051-9. PMID: 22438230; PMCID: PMC3387422.
    33. Ryan WD, Trivedi N, Benirschke K, Lacoursiere DY, Parast MM. Placental histologic criteria for diagnosis of cord accident: sensitivity and specificity. Pediatr Dev Pathol. 2012 Jul-Aug; 15(4):275-80. PMID: 22400796.
      View in: PubMed
    34. Laury AR, Ning G, Quick CM, Bijron J, Parast MM, Betensky RA, Vargas SO, McKeon FD, Xian W, Nucci MR, Crum CP. Fallopian tube correlates of ovarian serous borderline tumors. Am J Surg Pathol. 2011 Dec; 35(12):1759-65. PMID: 22089527; PMCID: PMC3219906.
    35. Quinn KH, Lacoursiere DY, Cui L, Bui J, Parast MM. The unique pathophysiology of early-onset severe preeclampsia: role of decidual T regulatory cells. J Reprod Immunol. 2011 Sep; 91(1-2):76-82. PMID: 21782252.
      View in: PubMed
    36. Rose JA, Rabenold JJ, Parast MM, Milstone DS, Abrahams VM, Riley JK. Peptidoglycan induces necrosis and regulates cytokine production in murine trophoblast stem cells. Am J Reprod Immunol. 2011 Sep; 66(3):209-22. PMID: 21385270; PMCID: PMC3137696.
    37. Taché V, LaCoursiere DY, Saleemuddin A, Parast MM. Placental expression of vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 correlates with severity of clinical preeclampsia and villous hypermaturity. Hum Pathol. 2011 Sep; 42(9):1283-8. PMID: 21334711.
      View in: PubMed
    38. Saleemuddin A, Tantbirojn P, Sirois K, Crum CP, Boyd TK, Tworoger S, Parast MM. Obstetric and perinatal complications in placentas with fetal thrombotic vasculopathy. Pediatr Dev Pathol. 2010 Nov-Dec; 13(6):459-64. PMID: 20438299.
      View in: PubMed
    39. Parast MM, Yu H, Ciric A, Salata MW, Davis V, Milstone DS. PPARgamma regulates trophoblast proliferation and promotes labyrinthine trilineage differentiation. PLoS One. 2009 Nov 30; 4(11):e8055. PMID: 19956639; PMCID: PMC2778869.
    40. Wintermark P, Boyd T, Parast MM, Van Marter LJ, Warfield SK, Robertson RL, Ringer SA. Fetal placental thrombosis and neonatal implications. Am J Perinatol. 2010 Mar; 27(3):251-6. PMID: 19806531; PMCID: PMC3694425.
    41. Quintero-Rivera F, Abreu-E-Lima P, Zhang IH, Parast MM. Homozygous alpha-thalassemia with trisomy 7 mosaicism in a live-born infant. Pediatr Hematol Oncol. 2009 Sep; 26(6):426-31. PMID: 19657992.
      View in: PubMed
    42. Carlson JW, Miron A, Jarboe EA, Parast MM, Hirsch MS, Lee Y, Muto MG, Kindelberger D, Crum CP. Serous tubal intraepithelial carcinoma: its potential role in primary peritoneal serous carcinoma and serous cancer prevention. J Clin Oncol. 2008 Sep 01; 26(25):4160-5. PMID: 18757330; PMCID: PMC2654373.
    43. Nagymanyoki Z, Growdon WB, Sarno J, Callahan MJ, Parast MM, Fulop V, Mok SC, Horowitz N, Berkowitz RS. Vascularization and expression of angiogenic factors in partial and complete molar pregnancies. J Reprod Med. 2008 Aug; 53(8):589-94. PMID: 18773623.
      View in: PubMed
    44. Nagymanyoki Z, Callahan MJ, Parast MM, Fulop V, Mok SC, Berkowitz RS. Immune cell profiling in intraplacental and postmolar choriocarcinomas. J Reprod Med. 2008 Aug; 53(8):558-64. PMID: 18773618.
      View in: PubMed
    45. Nagymanyoki Z, Butler MO, Callahan MJ, Parast MM, Fulop V, Mok SC, Berkowitz RS. Antigen-specific T cell immune response detected by skewed T cell receptor usage in normal placenta and complete molar pregnancy. J Reprod Med. 2008 Jul; 53(7):528-34. PMID: 18720929.
      View in: PubMed
    46. Parast MM, Crum CP, Boyd TK. Placental histologic criteria for umbilical blood flow restriction in unexplained stillbirth. Hum Pathol. 2008 Jun; 39(6):948-53. PMID: 18430456.
      View in: PubMed
    47. Nagymanyoki Z, Callahan MJ, Parast MM, Berkowitz RS, Mok SC, Fulop V. Overexpression of laminin receptor 1 on decidual cells in partial and complete mole. Gynecol Oncol. 2008 Jan; 108(1):121-5. PMID: 17928039.
      View in: PubMed
    48. Nagymanyoki Z, Callahan MJ, Parast MM, Fulop V, Mok SC, Berkowitz RS. Immune cell profiling in normal pregnancy, partial and complete molar pregnancy. Gynecol Oncol. 2007 Nov; 107(2):292-7. PMID: 17878059.
      View in: PubMed
    49. Lee Y, Kim KR, McKeon F, Yang A, Boyd TK, Crum CP, Parast MM. A unifying concept of trophoblastic differentiation and malignancy defined by biomarker expression. Hum Pathol. 2007 Jul; 38(7):1003-13. PMID: 17397906.
      View in: PubMed
    50. Boukhelifa M, Moza M, Johansson T, Rachlin A, Parast M, Huttelmaier S, Roy P, Jockusch BM, Carpen O, Karlsson R, Otey CA. The proline-rich protein palladin is a binding partner for profilin. FEBS J. 2006 Jan; 273(1):26-33. PMID: 16367745.
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    51. Parast MM, Eudy G, Gow KW, Amin M, Shehata B. A unique case of renal carcinoma with Xp11.2 translocations/ TFE3 gene fusions in a 3-year-old child, with coexistent von Hippel-Lindau gene mutation. Pediatr Dev Pathol. 2004 Jul-Aug; 7(4):403-6. PMID: 15383938.
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    52. Boukhelifa M, Parast MM, Bear JE, Gertler FB, Otey CA. Palladin is a novel binding partner for Ena/VASP family members. Cell Motil Cytoskeleton. 2004 May; 58(1):17-29. PMID: 14983521.
      View in: PubMed
    53. Ono K, Parast M, Alberico C, Benian GM, Ono S. Specific requirement for two ADF/cofilin isoforms in distinct actin-dependent processes in Caenorhabditis elegans. J Cell Sci. 2003 May 15; 116(Pt 10):2073-85. PMID: 12679387.
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