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    Edland, Steven

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentFamily Medicine and Public Health
    Address9500 Gilman Drive #0725
    CA La Jolla 92093
    Phone858-246-1250
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      Collapse Overview 
      Collapse Overview
      Dr. Edland’s primary research interest is the epidemiology, treatment, and prevention of chronic disease. Prior to joining UCSD, Dr. Edland provided statistical support to a number of nationally recognized epidemiologic investigations of Alzheimer’s disease, including the Consortium the Establish a Registry of Alzheimer’s Disease, the first nationwide longitudinal cohort study of Alzheimer’s disease, the Mayo Clinic medical records-based Olmsted County Rochester Epidemiology Project, the “Kame study” of the prevalence, incidence, and risk factors for dementia and Alzheimer’s disease in the Japanese-American residents of King County, WA, and other NIA program project Alzheimer’s disease model patient registries. Dr. Edland’s expertise in longitudinal analysis is now brought to bear in support of cohort studies and clinical trials administered by the UCSD Department of Neurosciences, where he has a joint appointment.

      Dr. Edland enjoys the collaborative research process and bridging the gap between mathematical statistics and research application, with substantial experience supporting both clinical and bench research, including 25 years of continuous involvement in Alzheimer’s Disease Research Centers (ADRCs), as founding director of the Mayo Clinic ADRC Biostatistics Core, and currently as director of the UCSD ADRC Biostatistics Core. Dr. Edland’s collaborations often evolve into ancillary publication of context-specific statistical methods.

      Dr. Edland’s current active independent research is on the improved design, implementation, and analysis of clinical trials of chronic progressive disease. For example, Dr. Edland is Principal Investigator of an NIA grant titled Optimizing Outcome Measures for Clinical Trials in Pre-Clinical Alzheimer's Disease, which will explore statistical methods of constructing outcome measures more sensitive to Alzheimer’s disease progression and drug treatment effects at the earliest stages of this disease. Dr. Edland serves on Data Safety Monitoring Boards for several multinational clinical trials, is an ad hoc member of the NIH Special Emphasis Panel Alzheimer’s Disease Pilot Clinical Trials (PAR 11-100), and is a standing member of the NIH Neurological, Aging and Musculoskeletal Epidemiology (NAME) Study Section.


      Collapse Research 
      Collapse Research Activities and Funding
      Neuropathologic substrates for motor and cognitive impairment in three existing cohort studies of Alzheimer's disease and related dementias
      NIH UF1AG057707Sep 15, 2017 - Jun 30, 2022
      Role: Subaward PI
      Pupillary Responses as a Risk and Staging Biomarker of Preclinical Alzheimer's Disease
      NIH/NIA R01AG054509May 15, 2017 - Apr 30, 2021
      Role: Co-Investigator
      The ESPINA Study Follow-up Examination in 2016: Environmental Pollutants and Child/Adolescent Development
      NIH/NIEHS R01ES025792Apr 1, 2016 - Mar 31, 2021
      Role: Co-Investigator
      Re-visiting Methods for MCI Diagnosis to Improve Biomarker and Trial Findings
      NIH/NIA R01AG049810Mar 15, 2016 - Feb 28, 2021
      Role: Principal Investigator
      Longitudinal Cognitive ERP studies: Advancement for AD Clinical Trials
      NIH/NIA R01AG048252Sep 1, 2015 - Apr 30, 2020
      Role: Co-Investigator
      Stanford Alzheimer's Disease Research Center
      NIH P50AG047366Jul 1, 2015 - Apr 30, 2020
      Role: Subaward PI
      Optimizing Outcome Measures for Clin. Trials in Pre-Clinical Alzheimer's Disease
      NIH/NIA R03AG047580Apr 15, 2015 - Mar 31, 2017
      Role: Principal Investigator
      Mayo Alzheimer's Disease Research Center
      NIH P50AG016574May 1, 1999 - Apr 30, 2019
      Role: Biostatistics Core Director

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Kaur A, Edland S, Peavy GM. The MoCA-Memory Index Score: An Efficient Alternative to Paragraph Recall for the Detection of Amnestic Mild Cognitive Impairment. Alzheimer Dis Assoc Disord. 2018 Jan 09. PMID: 29319601.
        View in: PubMed
      2. Wang H, Stewart T, Toledo JB, Ginghina C, Tang L, Atik A, Aro P, Shaw LM, Trojanowski JQ, Galasko DR, Edland S, Jensen PH, Shi M, Zhang J. A Longitudinal Study of Total and Phosphorylated a-Synuclein with Other Biomarkers in Cerebrospinal Fluid of Alzheimer's Disease and Mild Cognitive Impairment. J Alzheimers Dis. 2018; 61(4):1541-1553. PMID: 29376878.
        View in: PubMed
      3. Edmonds EC, Ard MC, Edland S, Galasko DR, Salmon DP, Bondi MW. Unmasking the benefits of donepezil via psychometrically precise identification of mild cognitive impairment: A secondary analysis of the ADCS vitamin E and donepezil in MCI study. Alzheimers Dement (N Y). 2018; 4:11-18. PMID: 29296659.
        View in: PubMed
      4. Jacobs DM, Ard MC, Salmon DP, Galasko DR, Bondi MW, Edland S. Potential implications of practice effects in Alzheimer's disease prevention trials. Alzheimers Dement (N Y). 2017 Nov; 3(4):531-535. PMID: 29124111.
        View in: PubMed
      5. Xiao MF, Xu D, Craig MT, Pelkey KA, Chien CC, Shi Y, Zhang J, Resnick S, Pletnikova O, Salmon D, Brewer J, Edland S, Wegiel J, Tycko B, Savonenko A, Reeves RH, Troncoso JC, McBain CJ, Galasko D, Worley PF. NPTX2 and cognitive dysfunction in Alzheimer's Disease. Elife. 2017 Mar 23; 6. PMID: 28440221.
        View in: PubMed
      6. Edland S, Ard MC, Li W, Jiang L. Design of pilot studies to inform the construction of composite outcome measures. Alzheimers Dement (N Y). 2017 Jun; 3(2):213-218. PMID: 28920073.
        View in: PubMed
      7. Kelley KD, Peavy G, Edland S, Rogers W, Riley DE, Bordelon Y, Standaert D, Reich SG, Litvan I. The Role of Stress as a Risk Factor for Progressive Supranuclear Palsy. J Parkinsons Dis. 2017; 7(2):377-383. PMID: 28409749.
        View in: PubMed
      8. Shifflett B, Huang R, Edland S. The MAX Statistic is Less Powerful for Genome Wide Association Studies Under Most Alternative Hypotheses. Int J Stat Med Res. 2017; 6(4):144-151. PMID: 29387290.
        View in: PubMed
      9. Edland S, Wergeland A, Kopperud R, Åsrud KS, Hoivik EA, Witsø SL, Æsøy R, Madsen L, Kristiansen K, Bakke M, Døskeland SO, Jonassen AK. Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling. Nutr Metab (Lond). 2016; 13:87. PMID: 27933093.
        View in: PubMed
      10. Syvertsen M, Hellum MK, Hansen G, Edland S, Nakken KO, Selmer KK, Koht J. Prevalence of juvenile myoclonic epilepsy in people <30 years of age-A population-based study in Norway. Epilepsia. 2017 01; 58(1):105-112. PMID: 27861775.
        View in: PubMed
      11. Linke SE, Strong DR, Myers MG, Edland S, Hofstetter CR, Al-Delaimy WK. The relationships among physical activity, sedentary behaviour, obesity and quitting behaviours within a cohort of smokers in California. Public Health. 2016 Dec; 141:232-240. PMID: 27932008.
        View in: PubMed
      12. Edland S, Ard MC, Sridhar J, Cobia D, Martersteck A, Mesulam MM, Rogalski EJ. Proof of concept demonstration of optimal composite MRI endpoints for clinical trials. Alzheimers Dement (N Y). 2016 Sep; 2(3):177-181. PMID: 28345017.
        View in: PubMed
      13. Peavy GM, Edland S, Toole BM, Hansen LA, Galasko DR, Mayo AM. Phenotypic differences based on staging of Alzheimer's neuropathology in autopsy-confirmed dementia with Lewy bodies. Parkinsonism Relat Disord. 2016 Oct; 31:72-78. PMID: 27475955.
        View in: PubMed
      14. Simonsen CS, Hansen G, Piehl F, Edland S. Chronic inflammatory demyelinating polyradiculoneuropathy occurring after autologous haematopoietic stem cell transplantation for multiple sclerosis. Mult Scler J Exp Transl Clin. 2016 Jan-Dec; 2:2055217316658304. PMID: 28607734.
        View in: PubMed
      15. Simonsen CS, Edland S, Berg-Hansen P, Celius EG. High prevalence and increasing incidence of multiple sclerosis in the Norwegian county of Buskerud. Acta Neurol Scand. 2017 Apr; 135(4):412-418. PMID: 27241360.
        View in: PubMed
      16. White LR, Edland S, Hemmy LS, Montine KS, Zarow C, Sonnen JA, Uyehara-Lock JH, Gelber RP, Ross GW, Petrovitch H, Masaki KH, Lim KO, Launer LJ, Montine TJ. Neuropathologic comorbidity and cognitive impairment in the Nun and Honolulu-Asia Aging Studies. Neurology. 2016 Mar 15; 86(11):1000-8. PMID: 26888993; PMCID: PMC4799714 [Available on 03/15/17].
      17. Liu L, Edland S, Myers MG, Hofstetter CR, Al-Delaimy WK. Smoking prevalence in urban and rural populations: findings from California between 2001 and 2012. Am J Drug Alcohol Abuse. 2016 Mar; 42(2):152-61. PMID: 26821213.
        View in: PubMed
      18. Calvo RY, Lindsay SP, Edland S, Macera CA, Wingard DL, Ohno-Machado L, Sise MJ. The differential associations of preexisting conditions with trauma-related outcomes in the presence of competing risks. Injury. 2016 Mar; 47(3):677-84. PMID: 26684173.
        View in: PubMed
      19. Ard MC, Raghavan N, Edland S. Optimal composite scores for longitudinal clinical trials under the linear mixed effects model. Pharm Stat. 2015 Sep-Oct; 14(5):418-26. PMID: 26223663.
        View in: PubMed
      20. Strong DR, Myers M, Linke S, Leas E, Hofstetter R, Edland S, Al-Delaimy WK. Gender differences influence overweight smokers' experimentation with electronic nicotine delivery systems. Addict Behav. 2015 Oct; 49:20-5. PMID: 26036665; PMCID: PMC4478105.
      21. Nation DA, Edmonds EC, Bangen KJ, Delano-Wood L, Scanlon BK, Han SD, Edland S, Salmon DP, Galasko DR, Bondi MW. Pulse pressure in relation to tau-mediated neurodegeneration, cerebral amyloidosis, and progression to dementia in very old adults. JAMA Neurol. 2015 May; 72(5):546-53. PMID: 25822631; PMCID: PMC4428938.
      22. Syvertsen M, Nakken KO, Edland S, Hansen G, Hellum MK, Koht J. Prevalence and etiology of epilepsy in a Norwegian county-A population based study. Epilepsia. 2015 May; 56(5):699-706. PMID: 25810072.
        View in: PubMed
      23. Young JE, Boulanger-Weill J, Williams DA, Woodruff G, Buen F, Revilla AC, Herrera C, Israel MA, Yuan SH, Edland S, Goldstein LS. Elucidating molecular phenotypes caused by the SORL1 Alzheimer's disease genetic risk factor using human induced pluripotent stem cells. Cell Stem Cell. 2015 Apr 02; 16(4):373-85. PMID: 25772071; PMCID: PMC4388804.
      24. Ziemssen T, Bajenaru OA, Carrá A, de Klippel N, Correia de Sá J, Edland S, Frederiksen JL, Heinzlef O, Karageorgiou KE, Lander Delgado RH, Landtblom AM, Macías Islas MA, Tubridy N, Gilgun-Sherki Y. Erratum to: A 2-year observational study of patients with relapsing-remitting multiple sclerosis converting to glatiramer acetate from other disease-modifying therapies: the COPTIMIZE trial. J Neurol. 2015 Jan; 262(1):248. PMID: 25417969.
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      25. Melberg T, Jørgensen M, Ørn S, Solli T, Edland S, Dickstein K. Safety and health status following early discharge in patients with acute myocardial infarction treated with primary PCI: a randomized trial. Eur J Prev Cardiol. 2015 Nov; 22(11):1427-34. PMID: 25398704.
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      26. Donohue MC, Moghadam SH, Roe AD, Sun CK, Edland S, Thomas RG, Petersen RC, Sano M, Galasko D, Aisen PS, Rissman RA. Longitudinal plasma amyloid beta in Alzheimer's disease clinical trials. Alzheimers Dement. 2015 Sep; 11(9):1069-79. PMID: 25301682; PMCID: PMC4387108.
      27. Lund C, Nakken KO, Edland S, Celius EG. Multiple sclerosis and seizures: incidence and prevalence over 40 years. Acta Neurol Scand. 2014 Dec; 130(6):368-73. PMID: 25209977.
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      28. Ziemssen T, Bajenaru OA, Carrá A, de Klippel N, de Sá JC, Edland S, Frederiksen JL, Heinzlef O, Karageorgiou KE, Lander Delgado RH, Landtblom AM, Macías Islas MA, Tubridy N, Gilgun-Sherki Y. A 2-year observational study of patients with relapsing-remitting multiple sclerosis converting to glatiramer acetate from other disease-modifying therapies: the COPTIMIZE trial. J Neurol. 2014 Nov; 261(11):2101-11. PMID: 25119836.
        View in: PubMed
      29. Smith SD, Marrone L, Gomez A, Johnson ML, Edland S, Beck E. Clinical outcomes of diabetic patients at a student-run free clinic project. Fam Med. 2014 Mar; 46(3):198-203. PMID: 24652638.
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      30. Leas EC, Zablocki RW, Edland S, Al-Delaimy WK. Smokers who report smoking but do not consider themselves smokers: a phenomenon in need of further attention. Tob Control. 2015 Jul; 24(4):400-3. PMID: 24500273.
        View in: PubMed
      31. Zablocki RW, Edland S, Myers MG, Strong DR, Hofstetter CR, Al-Delaimy WK. Smoking ban policies and their influence on smoking behaviors among current California smokers: a population-based study. Prev Med. 2014 Feb; 59:73-8. PMID: 24291748.
        View in: PubMed
      32. Nation DA, Edland S, Bondi MW, Salmon DP, Delano-Wood L, Peskind ER, Quinn JF, Galasko DR. Pulse pressure is associated with Alzheimer biomarkers in cognitively normal older adults. Neurology. 2013 Dec 03; 81(23):2024-7. PMID: 24225352; PMCID: PMC3854831.
      33. Myers MG, Doran NM, Edland S, Schweizer CA, Wall TL. Cigarette smoking initiation during college predicts future alcohol involvement: a matched-samples study. J Stud Alcohol Drugs. 2013 Nov; 74(6):909-16. PMID: 24172118.
        View in: PubMed
      34. Campos M, Edland S, Peavy GM. Exploratory study of apolipoprotein E e4 genotype and risk of Alzheimer's disease in Mexican Hispanics. J Am Geriatr Soc. 2013 Jun; 61(6):1038-40. PMID: 23772735; PMCID: PMC3694500.
      35. Nagle BJ, Usita PM, Edland S. United States medical students' knowledge of Alzheimer disease. J Educ Eval Health Prof. 2013; 10:4. PMID: 23750313; PMCID: PMC3674970.
      36. Sherzai A, Edland S, Masliah E, Hansen L, Pizzo DP, Sherzai A, Corey-Bloom J. Spongiform change in dementia with Lewy bodies and Alzheimer disease. Alzheimer Dis Assoc Disord. 2013 Apr-Jun; 27(2):157-61. PMID: 22546782.
        View in: PubMed
      37. Ard MC, Galasko DR, Edland S. Improved statistical power of Alzheimer clinical trials by item-response theory: proof of concept by application to the activities of daily living scale. Alzheimer Dis Assoc Disord. 2013 Apr-Jun; 27(2):187-91. PMID: 22874658; PMCID: PMC4362713.
      38. Peavy GM, Salmon DP, Edland S, Tam S, Hansen LA, Masliah E, Galasko D, Hamilton JM. Neuropsychiatric features of frontal lobe dysfunction in autopsy-confirmed patients with lewy bodies and "pure" Alzheimer disease. Am J Geriatr Psychiatry. 2013 Jun; 21(6):509-19. PMID: 23567425; PMCID: PMC3664517.
      39. Peavy GM, Santiago DP, Edland S. Subjective memory complaints are associated with diurnal measures of salivary cortisol in cognitively intact older adults. Am J Geriatr Psychiatry. 2013 Sep; 21(9):925-8. PMID: 23567387; PMCID: PMC3516632.
      40. Myers MG, Edland S, Hofstetter CR, Al-Delaimy WK. Perceived price sensitivity by ethnicity and smoking frequency among California Hispanic and non-Hispanic white smokers. Nicotine Tob Res. 2013 Jun; 15(6):1069-74. PMID: 23136268.
        View in: PubMed
      41. Brody BL, Field LC, Roch-Levecq AC, Depp C, Edland S, Minasyan L, Brown SI. Computer use among patients with age-related macular degeneration. Ophthalmic Epidemiol. 2012 Aug; 19(4):190-5. PMID: 22775273.
        View in: PubMed
      42. Pillai JA, Hansen LA, Masliah E, Goldstein JL, Edland S, Corey-Bloom J. Clinical severity of Huntington's disease does not always correlate with neuropathologic stage. Mov Disord. 2012 Aug; 27(9):1099-103. PMID: 22674458; PMCID: PMC3412903.
      43. Tang Y, Scott DA, Das U, Edland S, Radomski K, Koo EH, Roy S. Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid ß-protein oligomers. Traffic. 2012 May; 13(5):681-93. PMID: 22309053; PMCID: PMC3593673.
      44. Brody BL, Field LC, Roch-Levecq AC, Moutier CY, Edland S, Brown SI. Treatment of depression associated with age-related macular degeneration: a double-blind, randomized, controlled study. Ann Clin Psychiatry. 2011 Nov; 23(4):277-84. PMID: 22073385.
        View in: PubMed
      45. Edland S, Galasko DR. Fractional synthesis and clearance rates for amyloid ß. Nat Med. 2011 Oct 11; 17(10):1178-9; author reply 1179-80. PMID: 21988985.
        View in: PubMed
      46. Smith JR, Edland S, Novotny TE, Hofstetter CR, White MM, Lindsay SP, Al-Delaimy WK. Increasing hookah use in California. Am J Public Health. 2011 Oct; 101(10):1876-9. PMID: 21852640; PMCID: PMC3222344.
      47. Sorensen PS, Lycke J, Erälinna JP, Edland S, Wu X, Frederiksen JL, Oturai A, Malmeström C, Stenager E, Sellebjerg F, Sondergaard HB. Simvastatin as add-on therapy to interferon β-1a for relapsing-remitting multiple sclerosis (SIMCOMBIN study): a placebo-controlled randomised phase 4 trial. Lancet Neurol. 2011 Aug; 10(8):691-701. PMID: 21742556.
        View in: PubMed
      48. Smith JR, Novotny TE, Edland S, Hofstetter CR, Lindsay SP, Al-Delaimy WK. Determinants of hookah use among high school students. Nicotine Tob Res. 2011 Jul; 13(7):565-72. PMID: 21454909.
        View in: PubMed
      49. Ard MC, Edland S. Power calculations for clinical trials in Alzheimer's disease. J Alzheimers Dis. 2011; 26 Suppl 3:369-77. PMID: 21971476; PMCID: PMC3568927.
      50. Ashford JW, Salehi A, Furst A, Bayley P, Frisoni GB, Jack CR, Sabri O, Adamson MM, Coburn KL, Olichney J, Schuff N, Spielman D, Edland S, Black S, Rosen A, Kennedy D, Weiner M, Perry G. Imaging the Alzheimer brain. J Alzheimers Dis. 2011; 26 Suppl 3:1-27. PMID: 21971448; PMCID: PMC3760773.
      51. McEvoy LK, Edland S, Holland D, Hagler DJ, Roddey JC, Fennema-Notestine C, Salmon DP, Koyama AK, Aisen PS, Brewer JB, Dale AM. Neuroimaging enrichment strategy for secondary prevention trials in Alzheimer disease. Alzheimer Dis Assoc Disord. 2010 Jul-Sep; 24(3):269-77. PMID: 20683184; PMCID: PMC2929320.
      52. Edland S, Emond JA, Aisen PS, Petersen RC. NIA-funded Alzheimer centers are more efficient than commercial clinical recruitment sites for conducting secondary prevention trials of dementia. Alzheimer Dis Assoc Disord. 2010 Apr-Jun; 24(2):159-64. PMID: 20505433; PMCID: PMC2922976.
      53. Lu PH, Edland S, Teng E, Tingus K, Petersen RC, Cummings JL. Donepezil delays progression to AD in MCI subjects with depressive symptoms. Neurology. 2009 Jun 16; 72(24):2115-21. PMID: 19528519; PMCID: PMC2697965.
      54. Ma QL, Galasko DR, Ringman JM, Vinters HV, Edland S, Pomakian J, Ubeda OJ, Rosario ER, Teter B, Frautschy SA, Cole GM. Reduction of SorLA/LR11, a sorting protein limiting beta-amyloid production, in Alzheimer disease cerebrospinal fluid. Arch Neurol. 2009 Apr; 66(4):448-57. PMID: 19364929; PMCID: PMC2742778.
      55. Vozdolska R, Sano M, Aisen P, Edland S. The net effect of alternative allocation ratios on recruitment time and trial cost. Clin Trials. 2009 Apr; 6(2):126-32. PMID: 19342464; PMCID: PMC2864093.
      56. Knopman DS, Edland S, Cha RH, Petersen RC, Rocca WA. Incident dementia in women is preceded by weight loss by at least a decade. Neurology. 2007 Aug 21; 69(8):739-46. PMID: 17709705.
        View in: PubMed
      57. Ferris SH, Aisen PS, Cummings J, Galasko D, Salmon DP, Schneider L, Sano M, Whitehouse PJ, Edland S, Thal LJ. ADCS Prevention Instrument Project: overview and initial results. Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4 Suppl 3):S109-23. PMID: 17135805.
        View in: PubMed
      58. Salmon DP, Cummings JL, Jin S, Sano M, Sperling RA, Zamrini E, Petersen RC, Edland S, Thal LJ, Ferris SH. ADCS Prevention Instrument Project: development of a brief verbal memory test for primary prevention clinical trials. Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4 Suppl 3):S139-46. PMID: 17135807.
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      59. Galasko D, Bennett DA, Sano M, Marson D, Kaye J, Edland S. ADCS Prevention Instrument Project: assessment of instrumental activities of daily living for community-dwelling elderly individuals in dementia prevention clinical trials. Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4 Suppl 3):S152-69. PMID: 17135809.
        View in: PubMed
      60. Patterson MB, Whitehouse PJ, Edland S, Sami SA, Sano M, Smyth K, Weiner MF. ADCS Prevention Instrument Project: quality of life assessment (QOL). Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4 Suppl 3):S179-90. PMID: 17135811.
        View in: PubMed
      61. Sano M, Zhu CW, Whitehouse PJ, Edland S, Jin S, Ernstrom K, Thomas RG, Thal LJ, Ferris SH. ADCS Prevention Instrument Project: pharmacoeconomics: assessing health-related resource use among healthy elderly. Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4 Suppl 3):S191-202. PMID: 17135812; PMCID: PMC3229195.
      62. Whitehouse PJ, Rajcan JL, Sami SA, Patterson MB, Smyth KA, Edland S, George DR. ADCS Prevention Instrument Project: pilot testing of a book club as a psychosocial intervention and recruitment and retention strategy. Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4 Suppl 3):S203-8. PMID: 17135813.
        View in: PubMed
      63. Knopman DS, Petersen RC, Cha RH, Edland S, Rocca WA. Incidence and causes of nondegenerative nonvascular dementia: a population-based study. Arch Neurol. 2006 Feb; 63(2):218-21. PMID: 16476810.
        View in: PubMed
      64. Myllykangas L, Wavrant-De Vrièze F, Polvikoski T, Notkola IL, Sulkava R, Niinistö L, Edland S, Arepalli S, Adighibe O, Compton D, Hardy J, Haltia M, Tienari PJ. Chromosome 21 BACE2 haplotype associates with Alzheimer's disease: a two-stage study. J Neurol Sci. 2005 Sep 15; 236(1-2):17-24. PMID: 16023140.
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      65. Knopman DS, Petersen RC, Cha RH, Edland S, Rocca WA. Coronary artery bypass grafting is not a risk factor for dementia or Alzheimer disease. Neurology. 2005 Oct 11; 65(7):986-90. PMID: 16217048.
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      66. Tsuang D, Simpson KL, Li G, Barnhart RL, Edland S, Bowen J, McCormick W, Teri L, Nochlin D, Larson EB, Thompson ML, Leverenz JB. Evaluation of selection bias in an incident-based dementia autopsy case series. Alzheimer Dis Assoc Disord. 2005 Apr-Jun; 19(2):67-73. PMID: 15942323; PMCID: PMC1524825.
      67. Josephs KA, Tang-Wai DF, Edland S, Knopman DS, Dickson DW, Parisi JE, Petersen RC, Jack CR, Boeve BF. Correlation between antemortem magnetic resonance imaging findings and pathologically confirmed corticobasal degeneration. Arch Neurol. 2004 Dec; 61(12):1881-4. PMID: 15596608.
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      68. Kantarci K, Petersen RC, Boeve BF, Knopman DS, Tang-Wai DF, O'Brien PC, Weigand SD, Edland S, Smith GE, Ivnik RJ, Ferman TJ, Tangalos EG, Jack CR. 1H MR spectroscopy in common dementias. Neurology. 2004 Oct 26; 63(8):1393-8. PMID: 15505154; PMCID: PMC2766798.
      69. Ensenauer R, Vockley J, Willard JM, Huey JC, Sass JO, Edland S, Burton BK, Berry SA, Santer R, Grünert S, Koch HG, Marquardt I, Rinaldo P, Hahn S, Matern D. A common mutation is associated with a mild, potentially asymptomatic phenotype in patients with isovaleric acidemia diagnosed by newborn screening. Am J Hum Genet. 2004 Dec; 75(6):1136-42. PMID: 15486829; PMCID: PMC1182150.
      70. Geda YE, Smith GE, Knopman DS, Boeve BF, Tangalos EG, Ivnik RJ, Mrazek DA, Edland S, Petersen RC. De novo genesis of neuropsychiatric symptoms in mild cognitive impairment (MCI). Int Psychogeriatr. 2004 Mar; 16(1):51-60. PMID: 15190996.
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      71. Harbo HF, Lie BA, Sawcer S, Celius EG, Dai KZ, Oturai A, Hillert J, Lorentzen AR, Laaksonen M, Myhr KM, Ryder LP, Fredrikson S, Nyland H, Sørensen PS, Sandberg-Wollheim M, Andersen O, Svejgaard A, Edland S, Mellgren SI, Compston A, Vartdal F, Spurkland A. Genes in the HLA class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis. Tissue Antigens. 2004 Mar; 63(3):237-47. PMID: 14989713.
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      72. Knopman DS, Petersen RC, Edland S, Cha RH, Rocca WA. The incidence of frontotemporal lobar degeneration in Rochester, Minnesota, 1990 through 1994. Neurology. 2004 Feb 10; 62(3):506-8. PMID: 14872045.
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      73. Edland S, Slager S, Farrer M. Genetic association studies in Alzheimer's disease research: challenges and opportunities. Stat Med. 2004 Jan 30; 23(2):169-78. PMID: 14716719.
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      74. Edland S. Insulin-degrading enzyme, apolipoprotein E, and Alzheimer's disease. J Mol Neurosci. 2004; 23(3):213-7. PMID: 15181249.
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      75. Tang-Wai DF, Knopman DS, Geda YE, Edland S, Smith GE, Ivnik RJ, Tangalos EG, Boeve BF, Petersen RC. Comparison of the short test of mental status and the mini-mental state examination in mild cognitive impairment. Arch Neurol. 2003 Dec; 60(12):1777-81. PMID: 14676056.
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      76. Edland S, Wavrant-De Vriesé F, Compton D, Smith GE, Ivnik R, Boeve BF, Tangalos EG, Petersen RC. Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE). Neurosci Lett. 2003 Jul 10; 345(1):21-4. PMID: 12809979.
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      77. Kantarci K, Reynolds G, Petersen RC, Boeve BF, Knopman DS, Edland S, Smith GE, Ivnik RJ, Tangalos EG, Jack CR. Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T. AJNR Am J Neuroradiol. 2003 May; 24(5):843-9. PMID: 12748083.
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      78. Knopman DS, Parisi JE, Boeve BF, Cha RH, Apaydin H, Salviati A, Edland S, Rocca WA. Vascular dementia in a population-based autopsy study. Arch Neurol. 2003 Apr; 60(4):569-75. PMID: 12707071.
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      79. Boeve B, McCormick J, Smith G, Ferman T, Rummans T, Carpenter T, Ivnik R, Kokmen E, Tangalos E, Edland S, Knopman D, Petersen R. Mild cognitive impairment in the oldest old. Neurology. 2003 Feb 11; 60(3):477-80. PMID: 12578930.
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      80. Knopman DS, Rocca WA, Cha RH, Edland S, Kokmen E. Survival study of vascular dementia in Rochester, Minnesota. Arch Neurol. 2003 Jan; 60(1):85-90. PMID: 12533093.
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      81. Knopman DS, Rocca WA, Cha RH, Edland S, Kokmen E. Incidence of vascular dementia in Rochester, Minn, 1985-1989. Arch Neurol. 2002 Oct; 59(10):1605-10. PMID: 12374499.
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      82. Edland S, Rocca WA, Petersen RC, Cha RH, Kokmen E. Dementia and Alzheimer disease incidence rates do not vary by sex in Rochester, Minn. Arch Neurol. 2002 Oct; 59(10):1589-93. PMID: 12374497.
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      83. Edland S, Xu Y, Plevak M, O'Brien P, Tangalos EG, Petersen RC, Jack CR. Total intracranial volume: normative values and lack of association with Alzheimer's disease. Neurology. 2002 Jul 23; 59(2):272-4. PMID: 12136069.
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      84. Leverenz JB, Agustin CM, Tsuang D, Peskind ER, Edland S, Nochlin D, DiGiacomo L, Bowen JD, McCormick WC, Teri L, Raskind MA, Kukull WA, Larson EB. Clinical and neuropathological characteristics of hippocampal sclerosis: a community-based study. Arch Neurol. 2002 Jul; 59(7):1099-106. PMID: 12117357.
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      85. Jack CR, Dickson DW, Parisi JE, Xu YC, Cha RH, O'Brien PC, Edland S, Smith GE, Boeve BF, Tangalos EG, Kokmen E, Petersen RC. Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia. Neurology. 2002 Mar 12; 58(5):750-7. PMID: 11889239; PMCID: PMC2745935.
      86. Kantarci K, Xu Y, Shiung MM, O'Brien PC, Cha RH, Smith GE, Ivnik RJ, Boeve BF, Edland S, Kokmen E, Tangalos EG, Petersen RC, Jack CR. Comparative diagnostic utility of different MR modalities in mild cognitive impairment and Alzheimer's disease. Dement Geriatr Cogn Disord. 2002; 14(4):198-207. PMID: 12411762; PMCID: PMC2796574.
      87. Edland S, Tobe VO, Rieder MJ, Bowen JD, McCormick W, Teri L, Schellenberg GD, Larson EB, Nickerson DA, Kukull WA. Mitochondrial genetic variants and Alzheimer disease: a case-control study of the T4336C and G5460A variants. Alzheimer Dis Assoc Disord. 2002 Jan-Mar; 16(1):1-7. PMID: 11882743.
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      88. McCurry SM, Gibbons LE, Uomoto JM, Thompson ML, Graves AB, Edland S, Bowen J, McCormick WC, Larson EB. Neuropsychological test performance in a cognitively intact sample of older Japanese American adults. Arch Clin Neuropsychol. 2001 Jul; 16(5):447-59. PMID: 14590159.
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      89. Castro E, Edland S, Lee L, Ogburn CE, Deeb SS, Brown G, Panduro A, Riestra R, Tilvis R, Louhija J, Penttinen R, Erkkola R, Wang L, Martin GM, Oshima J. Polymorphisms at the Werner locus: II. 1074Leu/Phe, 1367Cys/Arg, longevity, and atherosclerosis. Am J Med Genet. 2000 Dec 11; 95(4):374-80. PMID: 11186893.
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      90. Edland S. Blomqvist revisited: how and when to test the relationship between level and longitudinal rate of change. Stat Med. 2000 Jun 15-30; 19(11-12):1441-52. PMID: 10844709.
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      91. Milliken JK, Edland S. Mixed effect models of longitudinal Alzheimer's disease data: a cautionary note. Stat Med. 2000 Jun 15-30; 19(11-12):1617-29. PMID: 10844723.
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      92. McCurry SM, Edland S, Teri L, Kukull WA, Bowen JD, McCormick WC, Larson EB. The cognitive abilities screening instrument (CASI): data from a cohort of 2524 cognitively intact elderly. Int J Geriatr Psychiatry. 1999 Oct; 14(10):882-8. PMID: 10521888.
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      93. Edland S, Graves AB, McCormick WC, Larson EB. Estimation and sample design in prevalence surveys of dementia. J Clin Epidemiol. 1999 May; 52(5):399-403. PMID: 10360334.
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      94. Linde L, Edland S, Bergström M. Auditory attention and multiattribute decision-making during a 33 h sleep-deprivation period: mean performance and between-subject dispersions. Ergonomics. 1999 May; 42(5):696-713. PMID: 10327892.
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      95. Myhr KM, Riise T, Green Lilleås FE, Beiske TG, Celius EG, Edland S, Jensen D, Larsen JP, Nilsen R, Nortvedt MW, Smievoll AI, Vedeler C, Nyland HI. Interferon-alpha2a reduces MRI disease activity in relapsing-remitting multiple sclerosis. Norwegian Study Group on Interferon-alpha in Multiple Sclerosis. Neurology. 1999 Mar 23; 52(5):1049-56. PMID: 10102427.
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      96. Castro E, Ogburn CE, Hunt KE, Tilvis R, Louhija J, Penttinen R, Erkkola R, Panduro A, Riestra R, Piussan C, Deeb SS, Wang L, Edland S, Martin GM, Oshima J. Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cys/Arg, and its stability in a population of Finnish centenarians. Am J Med Genet. 1999 Feb 19; 82(5):399-403. PMID: 10069711.
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      97. Burgess JL, Brodkin CA, Daniell WE, Pappas GP, Keifer MC, Stover BD, Edland S, Barnhart S. Longitudinal decline in measured firefighter single-breath diffusing capacity of carbon monoxide values. A respiratory surveillance dilemma. Am J Respir Crit Care Med. 1999 Jan; 159(1):119-24. PMID: 9872828.
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      98. Craft S, Teri L, Edland S, Kukull WA, Schellenberg G, McCormick WC, Bowen JD, Larson EB. Accelerated decline in apolipoprotein E-epsilon4 homozygotes with Alzheimer's disease. Neurology. 1998 Jul; 51(1):149-53. PMID: 9674794.
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      99. Edland S, Wijsman EM, Schoder-Ehri GL, Leverenz JB. Little evidence of reduced survival to adulthood of apoE epsilon4 homozygotes in Down's syndrome. Neuroreport. 1997 Nov 10; 8(16):3463-5. PMID: 9427308.
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      100. Edland S, Beekly D, Barnhart RL, van Belle G. Design and implementation of a longitudinal multicenter database. Neurology. 1997 Sep; 49(3 Suppl 3):S17-9. PMID: 9310509.
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