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John Kelsoe

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentPsychiatry
Address9500 Gilman Drive #0689
La Jolla CA 92093
Phone858-534-5927
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    Biography

    Dr. Kelsoe graduated from medical school at the University of Alabama, Birmingham in 1981. He completed internship training at Washington University in St. Louis and psychiatry residency at UC San Diego. He then went to the National Institute of Mental Health in Bethesda, Maryland for 4 years and returned to San Diego to join the Department of Psychiatry faculty in 1989.

    Research Interests

    Dr. Kelsoe’s longstanding research focus has been the genetics of psychiatric illness, bipolar disorder in particular. Over the past 20 years, his work has been focused on using a variety of molecular genetic methods to identify the specific genes that predispose to bipolar disorder. He has pursued this primarily by using positional cloning methods such as linkage and association in families in which the illness is genetically transmitted. He has also employed animal models of bipolar disorder in order to identify possible candidate genes that can then be tested in clinical populations. This approach has led to the recent identification of the gene for G protein receptor kinase 3 (GRK3) as a likely gene for bipolar disorder on chromosome 22. Dr. Kelsoe is currently actively engaged in genome wide association studies of bipolar disorder. He directs the Bipolar Genome Study (BiGS) which is a 13-site consortium focused on identifying genes for bipolar disorder and their relationship to clinical symptoms. He also co-directs the Psychiatric GWAS Consortium for Bipolar Disorder (PGC-BD) which is an international collaborative effort designed to identify genes for bipolar disorder in a sample of over 10,000 patients. These large exciting new technological approaches promise great advances in understanding the causes of bipolar disorder.

    Clinical Information

    Dr. Kelsoe’s primary clinical focus is the treatment of refractory mood disorders. He is the Medical Director of the STEP Clinic at the VA Hospital where they specialize in the treatment of chronic and refractory mood disorders. Patients at this clinic receive a thorough diagnostic evaluation and are eligible to participate in longitudinal research studies of the ability of genes to predict course, outcome, and treatment response.


    Collapse Research 
    Collapse Research Activities and Funding
    The Bipolar Genome Study
    NIH/NIMH R01MH094483Jul 1, 2012 - Apr 30, 2015
    Role: Principal Investigator
    Genetic Predictors of Lithium Response in Bipolar Disorder
    VA I01CX000363Oct 1, 2010 - Sep 30, 2015
    Role: Principal Investigator
    Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder
    NIH/NIMH U01MH092758Sep 10, 2010 - May 31, 2015
    Role: Principal Investigator
    Analysis of Whole Genome Association Data for Bipolar Disorder
    NIH/NIMH R01MH081804Sep 27, 2007 - Sep 26, 2009
    Role: Principal Investigator
    Genomic Association Study of Bipolar Disorder
    NIH/NIMH R01MH078151Aug 1, 2007 - May 31, 2011
    Role: Principal Investigator
    Genomic studies of bipolar disorder and chromosome 22
    NIH/NIMH R01MH068503Apr 1, 2004 - Jan 31, 2010
    Role: Principal Investigator
    Microarray studies of amphetamine models of psychosis
    NIH/NIDA R01DA013769Sep 30, 2001 - Jun 30, 2004
    Role: Principal Investigator
    Collaborative Genomic Study of Bipolar Disorder
    NIH/NIMH R01MH059567Sep 30, 1998 - Nov 30, 2008
    Role: Principal Investigator
    GENETIC LINKAGE STUDIES OF BIPOLAR AFFECTIVE DISORDER
    NIH/NIMH R29MH047612Mar 1, 1992 - Feb 28, 1997
    Role: Principal Investigator
    Fellowship on Biological Psychiatry and Neuroscience
    NIH/NIMH T32MH018399Jul 15, 1986 - Jun 30, 2022
    Role: Principal Investigator
    PSYCHOBIOLOGICAL STUDY OF PSYCHIATRIC DISORDERS
    NIH/NIMH P30MH030914Sep 29, 1977 - Dec 31, 2003
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
    Role: Co-Investigator

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    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kalman JL, Papiol S, Forstner AJ, Heilbronner U, Degenhardt F, Strohmaier J, Adli M, Adorjan K, Akula N, Alda M, Anderson-Schmidt H, Andlauer TF, Anghelescu IG, Ardau R, Arias B, Arolt V, Aubry JM, Backlund L, Bartholdi K, Bauer M, Baune BT, Becker T, Bellivier F, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Brichant-Petitjean C, Budde M, Cervantes P, Chillotti C, Cichon S, Clark SR, Colom F, Comes AL, Cruceanu C, Czerski PM, Dannlowski U, Dayer A, Del Zompo M, DePaulo JR, Dietrich DE, Étain B, Ethofer T, Falkai P, Fallgatter A, Figge C, Flatau L, Folkerts H, Frisen L, Frye MA, Fullerton JM, Gade K, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Gryaznova A, Hake M, Hauser J, Herms S, Hoffmann P, Hou L, Jäger M, Jamain S, Jiménez E, Juckel G, Kahn JP, Kassem L, Kelsoe J, Kittel-Schneider S, Kliwicki S, Klohn-Sagatholislam F, Koller M, König B, Konrad C, Lackner N, Laje G, Landén M, Lang FU, Lavebratt C, Leboyer M, Leckband SG, Maj M, Manchia M, Martinsson L, McCarthy MJ, McElroy SL, McMahon FJ, Mitchell PB, Mitjans M, Mondimore FM, Monteleone P, Nieratschker V, Nievergelt CM, Novák T, Ösby U, Pfennig A, Potash JB, Reich-Erkelenz D, Reif A, Reimer J, Reininghaus E, Reitt M, Ripke S, Rouleau GA, Rybakowski JK, Schalling M, Scherk H, Schmauß M, Schofield PR, Schubert KO, Schulte EC, Schulz S, Senner F, Severino G, Shekhtman T, Shilling PD, Simhandl C, Slaney CM, Spitzer C, Squassina A, Stamm T, Stegmaier S, Stierl S, Stopkova P, Thiel A, Tighe SK, Tortorella A, Turecki G, Vieta E, Veeh J, von Hagen M, Wigand ME, Wiltfang J, Witt S, Wright A, Zandi PP, Zimmermann J, Nöthen M, Rietschel M, Schulze TG. Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study. Bipolar Disord. 2018 Jun 28. PMID: 29956436.
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    2. Reinbold CS, Forstner AJ, Hecker J, Fullerton JM, Hoffmann P, Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Marie-Claire C, Cervantes P, Chen GB, Chen HC, Chillotti C, Clark SR, Colom F, Cousins DA, Cruceanu C, Czerski PM, Dayer A, Étain B, Falkai P, Frisén L, Gard S, Garnham JS, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Herms S, Jamain S, Jiménez E, Kahn JP, Kassem L, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Lackner N, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, López Jaramillo CA, MacQueen G, Manchia M, Martinsson L, Mattheisen M, McCarthy MJ, McElroy SL, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Ösby U, Ozaki N, Perlis RH, Pfennig A, Reich-Erkelenz D, Rouleau GA, Schofield PR, Schubert KO, Schweizer BW, Seemüller F, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Smoller JW, Squassina A, Stamm TJ, Stopkova P, Tighe SK, Tortorella A, Turecki G, Volkert J, Witt SH, Wright AJ, Young LT, Zandi PP, Potash JB, DePaulo JR, Bauer M, Reininghaus E, Novák T, Aubry JM, Maj M, Baune BT, Mitchell PB, Vieta E, Frye MA, Rybakowski JK, Kuo PH, Kato T, Grigoroiu-Serbanescu M, Reif A, Del Zompo M, Bellivier F, Schalling M, Wray NR, Kelsoe J, Alda M, McMahon FJ, Schulze TG, Rietschel M, Nöthen MM, Cichon S. Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder. Front Psychiatry. 2018; 9:207. PMID: 29904359.
      View in: PubMed
    3. Rangan AV, McGrouther CC, Kelsoe J, Schork N, Stahl E, Zhu Q, Krishnan A, Yao V, Troyanskaya O, Bilaloglu S, Raghavan P, Bergen S, Jureus A, Landen M. A loop-counting method for covariate-corrected low-rank biclustering of gene-expression and genome-wide association study data. PLoS Comput Biol. 2018 May 14; 14(5):e1006105. PMID: 29758032.
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    4. McCarthy MJ, Korelova O, Demodena A, Kelsoe J. A common genetic variant in CACNA1C predicts heart rate in patients with bipolar disorder. Psychiatry Res. 2018 May; 263:294-295. PMID: 29395250.
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    5. Amare AT, Schubert KO, Hou L, Clark SR, Papiol S, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hsu YH, Shekhtman T, Adli M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, Bengesser S, Biernacka JM, Birner A, Brichant-Petitjean C, Cervantes P, Chen HC, Chillotti C, Cichon S, Cruceanu C, Czerski PM, Dalkner N, Dayer A, Del Zompo M, DePaulo JR, Étain B, Falkai P, Forstner AJ, Frisen L, Frye MA, Fullerton JM, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jiménez E, Kahn JP, Kassem L, Kuo PH, Kato T, Kelsoe J, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Tortorella A, Manchia M, Martinsson L, McCarthy MJ, McElroy S, Colom F, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Novák T, O'Donovan C, Ozaki N, Ösby U, Pfennig A, Potash JB, Reif A, Reininghaus E, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schweizer BW, Severino G, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Maj M, Turecki G, Vieta E, Volkert J, Witt S, Wright A, Zandi PP, Mitchell PB, Bauer M, Alda M, Rietschel M, McMahon FJ, Schulze TG, Baune BT. Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study. JAMA Psychiatry. 2018 Jan 01; 75(1):65-74. PMID: 29121268.
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    6. Minassian A, Young JW, Geyer MA, Kelsoe J, Perry W. The COMT Val158Met Polymorphism and Exploratory Behavior in Bipolar Mania. Mol Neuropsychiatry. 2018 Feb; 3(3):151-156. PMID: 29594134.
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    7. Miller ND, Kelsoe J. Unraveling the biology of bipolar disorder using induced pluripotent stem-derived neurons. Bipolar Disord. 2017 Nov; 19(7):544-551. PMID: 29116664.
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    8. Milanesi E, Voinsky I, Hadar A, Srouji A, Maj C, Shekhtman T, Gershovits M, Gilad S, Chillotti C, Squassina A, Potash JB, Schulze TG, Goes FS, Zandi P, Kelsoe J, Gurwitz D. RNA sequencing of bipolar disorder lymphoblastoid cell lines implicates the neurotrophic factor HRP-3 in lithium's clinical efficacy. World J Biol Psychiatry. 2017 Sep 22; 1-13. PMID: 28854847.
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    9. Santos R, Vadodaria KC, Jaeger BN, Mei A, Lefcochilos-Fogelquist S, Mendes APD, Erikson G, Shokhirev M, Randolph-Moore L, Fredlender C, Dave S, Oefner R, Fitzpatrick C, Pena M, Barron JJ, Ku M, Denli AM, Kerman BE, Charnay P, Kelsoe J, Marchetto MC, Gage FH. Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 06 06; 8(6):1757-1769. PMID: 28591655.
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    10. Voegeli G, Ramoz N, Shekhtman T, Courtet P, Gorwood P, Kelsoe J. Neurotrophin Genes and Antidepressant-Worsening Suicidal Ideation: A Prospective Case-Control Study. Int J Neuropsychopharmacol. 2016 11; 19(11). PMID: 27378793.
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    11. Breen G, Li Q, Roth BL, O'Donnell P, Didriksen M, Dolmetsch R, O'Reilly PF, Gaspar HA, Manji H, Huebel C, Kelsoe J, Malhotra D, Bertolino A, Posthuma D, Sklar P, Kapur S, Sullivan PF, Collier DA, Edenberg HJ. Translating genome-wide association findings into new therapeutics for psychiatry. Nat Neurosci. 2016 10 26; 19(11):1392-1396. PMID: 27786187.
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    12. van Hulzen KJE, Scholz CJ, Franke B, Ripke S, Klein M, McQuillin A, Sonuga-Barke EJ, Kelsoe J, Landén M, Andreassen OA, Lesch KP, Weber H, Faraone SV, Arias-Vasquez A, Reif A. Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence From Genome-wide Association Study Meta-analysis. Biol Psychiatry. 2017 Nov 01; 82(9):634-641. PMID: 27890468.
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    13. Nakajima K, Kazuno AA, Kelsoe J, Nakanishi M, Takumi T, Kato T. Exome sequencing in the knockin mice generated using the CRISPR/Cas system. Sci Rep. 2016 Oct 04; 6:34703. PMID: 27698470.
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    14. Qiu F, Akiskal HS, Kelsoe J, Greenwood TA. Factor analysis of temperament and personality traits in bipolar patients: Correlates with comorbidity and disorder severity. J Affect Disord. 2017 01 01; 207:282-290. PMID: 27741464.
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    15. Hou L, Bergen SE, Akula N, Song J, Hultman CM, Landén M, Adli M, Alda M, Ardau R, Arias B, Aubry JM, Backlund L, Badner JA, Barrett TB, Bauer M, Baune BT, Bellivier F, Benabarre A, Bengesser S, Berrettini WH, Bhattacharjee AK, Biernacka JM, Birner A, Bloss CS, Brichant-Petitjean C, Bui ET, Byerley W, Cervantes P, Chillotti C, Cichon S, Colom F, Coryell W, Craig DW, Cruceanu C, Czerski PM, Davis T, Dayer A, Degenhardt F, Del Zompo M, DePaulo JR, Edenberg HJ, Étain B, Falkai P, Foroud T, Forstner AJ, Frisén L, Frye MA, Fullerton JM, Gard S, Garnham JS, Gershon ES, Goes FS, Greenwood TA, Grigoroiu-Serbanescu M, Hauser J, Heilbronner U, Heilmann-Heimbach S, Herms S, Hipolito M, Hitturlingappa S, Hoffmann P, Hofmann A, Jamain S, Jiménez E, Kahn JP, Kassem L, Kelsoe J, Kittel-Schneider S, Kliwicki S, Koller DL, König B, Lackner N, Laje G, Lang M, Lavebratt C, Lawson WB, Leboyer M, Leckband SG, Liu C, Maaser A, Mahon PB, Maier W, Maj M, Manchia M, Martinsson L, McCarthy MJ, McElroy SL, McInnis MG, McKinney R, Mitchell PB, Mitjans M, Mondimore FM, Monteleone P, Mühleisen TW, Nievergelt CM, Nöthen MM, Novák T, Nurnberger JI, Nwulia EA, Ösby U, Pfennig A, Potash JB, Propping P, Reif A, Reininghaus E, Rice J, Rietschel M, Rouleau GA, Rybakowski JK, Schalling M, Scheftner WA, Schofield PR, Schork NJ, Schulze TG, Schumacher J, Schweizer BW, Severino G, Shekhtman T, Shilling PD, Simhandl C, Slaney CM, Smith EN, Squassina A, Stamm T, Stopkova P, Streit F, Strohmaier J, Szelinger S, Tighe SK, Tortorella A, Turecki G, Vieta E, Volkert J, Witt SH, Wright A, Zandi PP, Zhang P, Zollner S, McMahon FJ. Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder. Hum Mol Genet. 2016 Aug 01; 25(15):3383-3394. PMID: 27329760.
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    16. Oedegaard KJ, Alda M, Anand A, Andreassen OA, Balaraman Y, Berrettini WH, Bhattacharjee A, Brennand KJ, Burdick KE, Calabrese JR, Calkin CV, Claasen A, Coryell WH, Craig D, DeModena A, Frye M, Gage FH, Gao K, Garnham J, Gershon E, Jakobsen P, Leckband SG, McCarthy MJ, McInnis MG, Maihofer AX, Mertens J, Morken G, Nievergelt CM, Nurnberger J, Pham S, Schoeyen H, Shekhtman T, Shilling PD, Szelinger S, Tarwater B, Yao J, Zandi PP, Kelsoe J. The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample. BMC Psychiatry. 2016 May 05; 16:129. PMID: 27150464; PMCID: PMC4857276.
    17. Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Banzato CEM, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Brichant-Petitjean C, Bui ET, Cervantes P, Chen GB, Chen HC, Chillotti C, Cichon S, Clark SR, Colom F, Cousins DA, Cruceanu C, Czerski PM, Dantas CR, Dayer A, Étain B, Falkai P, Forstner AJ, Frisén L, Fullerton JM, Gard S, Garnham JS, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jiménez E, Kahn JP, Kassem L, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Lackner N, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Jaramillo CAL, MacQueen G, Manchia M, Martinsson L, Mattheisen M, McCarthy MJ, McElroy SL, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Ösby U, Ozaki N, Perlis RH, Pfennig A, Reich-Erkelenz D, Rouleau GA, Schofield PR, Schubert KO, Schweizer BW, Seemüller F, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Smoller JW, Squassina A, Stamm T, Stopkova P, Tighe SK, Tortorella A, Turecki G, Volkert J, Witt S, Wright A, Young LT, Zandi PP, Potash JB, DePaulo JR, Bauer M, Reininghaus EZ, Novák T, Aubry JM, Maj M, Baune BT, Mitchell PB, Vieta E, Frye MA, Rybakowski JK, Kuo PH, Kato T, Grigoroiu-Serbanescu M, Reif A, Del Zompo M, Bellivier F, Schalling M, Wray NR, Kelsoe J, Alda M, Rietschel M, McMahon FJ, Schulze TG. Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study. Lancet. 2016 Mar 12; 387(10023):1085-1093. PMID: 26806518.
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    18. Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames T, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, Calabrese JR, Oedegaard KJ, McCarthy MJ, Zandi PP, Alda M, Nievergelt CM. Erratum: Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature. 2016 Feb 11; 530(7589):242. PMID: 26605530.
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    19. Webb A, Papp AC, Curtis A, Newman LC, Pietrzak M, Seweryn M, Handelman SK, Rempala GA, Wang D, Graziosa E, Tyndale RF, Lerman C, Kelsoe J, Mash DC, Sadee W. RNA sequencing of transcriptomes in human brain regions: protein-coding and non-coding RNAs, isoforms and alleles. BMC Genomics. 2015 Nov 23; 16:990. PMID: 26597164; PMCID: PMC4657279.
    20. Andreassen OA, Thompson WK, Schork AJ, Ripke S, Mattingsdal M, Kelsoe J, Kendler KS, O'Donovan MC, Rujescu D, Werge T, Sklar P. Correction: Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate. PLoS Genet. 2015 Nov; 11(11):e1005544. PMID: 26540268; PMCID: PMC4634985.
    21. Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames T, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, Calabrese JR, Ødegaard KJ, McCarthy MJ, Zandi PP, Alda M, Alba M, Nievergelt CM. Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature. 2015 Nov 05; 527(7576):95-9. PMID: 26524527; PMCID: PMC4742055.
    22. McCarthy MJ, Le Roux MJ, Wei H, Beesley S, Kelsoe J, Welsh DK. Calcium channel genes associated with bipolar disorder modulate lithium's amplification of circadian rhythms. Neuropharmacology. 2016 Feb; 101:439-48. PMID: 26476274.
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    23. Liu X. A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region. J Affect Disord. 2016 Jan 01; 189:141-9. PMID: 26433762; PMCID: PMC4640946 [Available on 01/01/17].
    24. Cosgrove VE, Kelsoe J, Suppes T. Toward a Valid Animal Model of Bipolar Disorder: How the Research Domain Criteria Help Bridge the Clinical-Basic Science Divide. Biol Psychiatry. 2016 Jan 01; 79(1):62-70. PMID: 26531027.
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    25. Song J, Wu Y, Nie F, Wang B, Li Y, Shu A, Ma Y, Zhang R, Kelsoe J, Ma J. [Analysis of chromosome regions 8q11.1-q13.3, 1q32-q34.3 and 14q31.1-q13.3 in a Chinese family with congenital preauricular fistula]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015 Aug; 32(4):472-5. PMID: 26252087.
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    26. Cho CH, Lee HJ, Woo HG, Choi JH, Greenwood TA, Kelsoe J. CDH13 and HCRTR2 May Be Associated with Hypersomnia Symptom of Bipolar Depression: A Genome-Wide Functional Enrichment Pathway Analysis. Psychiatry Investig. 2015 Jul; 12(3):402-7. PMID: 26207136; PMCID: PMC4504925.
    27. Zhang R, Yao J, Xu P, Ji B, Voegeli G, Hou W, Li H, Wang Y, Kelsoe J, Ma J. Association between genetic variants of DVWA and osteoarthritis of the knee and hip: a comprehensive meta-analysis. Int J Clin Exp Med. 2015; 8(6):9430-7. PMID: 26309605; PMCID: PMC4538189.
    28. Ji B, Higa KK, Kelsoe J, Zhou X. Over-expression of XIST, the Master Gene for X Chromosome Inactivation, in Females With Major Affective Disorders. EBioMedicine. 2015 Aug; 2(8):909-18. PMID: 26425698; PMCID: PMC4563114.
    29. Burton CZ, Vella L, Kelsoe J, Bilder RM, Twamley EW. Catechol-O-methyltransferase genotype and response to Compensatory Cognitive Training in outpatients with schizophrenia. Psychiatr Genet. 2015 Jun; 25(3):131-4. PMID: 25748092.
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    30. Zhang R, Yao J, Xu P, Ji B, Luck JV, Chin B, Lu S, Kelsoe J, Ma J. A comprehensive meta-analysis of association between genetic variants of GDF5 and osteoarthritis of the knee, hip and hand. Inflamm Res. 2015 Jun; 64(6):405-14. PMID: 25894512.
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    31. Li D, Xu R, Huang F, Wang B, Tao Y, Jiang Z, Li H, Yao J, Xu P, Wu X, Ren L, Zhang R, Kelsoe J, Ma J. A novel missense mutation in collagenous domain of EDA gene in a Chinese family with X-linked hypohidrotic ectodermal dysplasia. J Genet. 2015 Mar; 94(1):115-9. PMID: 25846883.
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    32. Ament SA, Szelinger S, Glusman G, Ashworth J, Hou L, Akula N, Shekhtman T, Badner JA, Brunkow ME, Mauldin DE, Stittrich AB, Rouleau K, Detera-Wadleigh SD, Nurnberger JI, Edenberg HJ, Gershon ES, Schork N. Rare variants in neuronal excitability genes influence risk for bipolar disorder. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):3576-81. PMID: 25730879; PMCID: PMC4371952.
    33. Fountoulakis KN, Gazouli M, Kelsoe J, Akiskal H. The pharmacodynamic properties of lurasidone and their role in its antidepressant efficacy in bipolar disorder. Eur Neuropsychopharmacol. 2015 Mar; 25(3):335-42. PMID: 25596883.
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    34. Kripke DF, Klimecki WT, Nievergelt CM, Rex KM, Murray SS, Shekhtman T, Tranah GJ, Loving RT, Lee HJ, Rhee MK, Shadan FF, Poceta JS, Jamil SM, Kline LE, Kelsoe J. Circadian polymorphisms in night owls, in bipolars, and in non-24-hour sleep cycles. Psychiatry Investig. 2014 Oct; 11(4):345-62. PMID: 25395965; PMCID: PMC4225198.
    35. Jacobsen KK, Nievergelt CM, Zayats T, Greenwood TA, Anttila V, Akiskal HS. Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder. J Affect Disord. 2015 Feb 01; 172:453-61. PMID: 25451450; PMCID: PMC4394021.
    36. Jalalat SZ, Kelsoe J, Cohen PR. Alopecia areata with white hair regrowth: case report and review of poliosis. Dermatol Online J. 2014 Sep 16; 20(9). PMID: 25244170.
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    37. Twamley EW, Hua JP, Burton CZ, Vella L, Chinh K, Bilder RM, Kelsoe J. Effects of COMT genotype on cognitive ability and functional capacity in individuals with schizophrenia. Schizophr Res. 2014 Oct; 159(1):114-7. PMID: 25139113.
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    38. Jamain S, Cichon S, Etain B, Mühleisen TW, Georgi A, Zidane N, Chevallier L, Deshommes J, Nicolas A, Henrion A, Degenhardt F, Mattheisen M, Priebe L, Mathieu F, Kahn JP, Henry C, Boland A, Zelenika D, Gut I, Heath S, Lathrop M, Maier W, Albus M, Rietschel M, Schulze TG, McMahon FJ, Kelsoe J, Hamshere M, Craddock N, Nöthen MM, Bellivier F, Leboyer M. Common and rare variant analysis in early-onset bipolar disorder vulnerability. PLoS One. 2014; 9(8):e104326. PMID: 25111785.
      View in: PubMed
    39. McCarthy MJ, Liang S, Spadoni AD, Kelsoe J, Simmons AN. Whole brain expression of bipolar disorder associated genes: structural and genetic analyses. PLoS One. 2014; 9(6):e100204. PMID: 24941232; PMCID: PMC4062532.
    40. Nurnberger JI, Koller DL, Jung J, Edenberg HJ, Foroud T, Guella I, Vawter MP, Kelsoe J. Identification of pathways for bipolar disorder: a meta-analysis. JAMA Psychiatry. 2014 Jun; 71(6):657-64. PMID: 24718920.
      View in: PubMed
    41. Salloum NC, McCarthy MJ, Leckband SG, Kelsoe J. Towards the clinical implementation of pharmacogenetics in bipolar disorder. BMC Med. 2014 May 30; 12:90. PMID: 24885933; PMCID: PMC4039055.
    42. Bleyer AJ, Kmoch S, Antignac C, Robins V, Kidd K, Kelsoe J, Hladik G, Klemmer P, Knohl SJ, Scheinman SJ, Vo N, Santi A, Harris A, Canaday O, Weller N, Hulick PJ, Vogel K, Rahbari-Oskoui FF, Tuazon J, Deltas C, Somers D, Megarbane A, Kimmel PL, Sperati CJ, Orr-Urtreger A, Ben-Shachar S, Waugh DA, McGinn S, Bleyer AJ, Hodanová K, Vylet'al P, Živná M, Hart TC, Hart PS. Variable clinical presentation of an MUC1 mutation causing medullary cystic kidney disease type 1. Clin J Am Soc Nephrol. 2014 Mar; 9(3):527-35. PMID: 24509297; PMCID: PMC3944763.
    43. Ruderfer DM, Fanous AH, Ripke S, McQuillin A, Amdur RL, Gejman PV, O'Donovan MC, Andreassen OA, Djurovic S, Hultman CM, Kelsoe J, Jamain S, Landén M, Leboyer M, Nimgaonkar V, Nurnberger J, Smoller JW, Craddock N, Corvin A, Sullivan PF, Holmans P, Sklar P, Kendler KS. Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. Mol Psychiatry. 2014 Sep; 19(9):1017-1024. PMID: 24280982; PMCID: PMC4033708.
    44. Greenwood TA, Badner JA, Byerley W, Keck PE, McElroy SL, Remick RA, Dessa Sadovnick A, Kelsoe J. Heritability and linkage analysis of personality in bipolar disorder. J Affect Disord. 2013 Nov; 151(2):748-55. PMID: 23972719; PMCID: PMC3797235.
    45. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet. 2013 Sep; 45(9):984-94. PMID: 23933821.
      View in: PubMed
    46. Falcone M, Smith RM, Chenoweth MJ, Bhattacharjee AK, Kelsoe J, Tyndale RF, Lerman C. Neuroimaging in psychiatric pharmacogenetics research: the promise and pitfalls. Neuropsychopharmacology. 2013 Nov; 38(12):2327-37. PMID: 23793356; PMCID: PMC3799069.
    47. Manchia M, Adli M, Akula N, Ardau R, Aubry JM, Backlund L, Banzato CE, Baune BT, Bellivier F, Bengesser S, Biernacka JM, Brichant-Petitjean C, Bui E, Calkin CV, Cheng AT, Chillotti C, Cichon S, Clark S, Czerski PM, Dantas C, Zompo MD, Depaulo JR, Detera-Wadleigh SD, Etain B, Falkai P, Frisén L, Frye MA, Fullerton J, Gard S, Garnham J, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Heilbronner U, Hoban R, Hou L, Jamain S, Kahn JP, Kassem L, Kato T, Kelsoe J, Kittel-Schneider S, Kliwicki S, Kuo PH, Kusumi I, Laje G, Lavebratt C, Leboyer M, Leckband SG, López Jaramillo CA, Maj M, Malafosse A, Martinsson L, Masui T, Mitchell PB, Mondimore F, Monteleone P, Nallet A, Neuner M, Novák T, O'Donovan C, Osby U, Ozaki N, Perlis RH, Pfennig A, Potash JB, Reich-Erkelenz D, Reif A, Reininghaus E, Richardson S, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schubert OK, Schweizer B, Seemüller F, Grigoroiu-Serbanescu M, Severino G, Seymour LR, Slaney C, Smoller JW, Squassina A, Stamm T, Steele J, Stopkova P, Tighe SK, Tortorella A, Turecki G, Wray NR, Wright A, Zandi PP, Zilles D, Bauer M, Rietschel M, McMahon FJ, Schulze TG, Alda M. Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report. PLoS One. 2013; 8(6):e65636. PMID: 23840348; PMCID: PMC3686769.
    48. Greenwood TA, Badner JA, Byerley W, Keck PE, McElroy SL, Remick RA, Sadovnick AD, Akiskal HS, Kelsoe J. Heritability and genome-wide SNP linkage analysis of temperament in bipolar disorder. J Affect Disord. 2013 Sep 25; 150(3):1031-40. PMID: 23759419; PMCID: PMC3759543.
    49. Schork AJ, Thompson WK, Pham P, Torkamani A, Roddey JC, Sullivan PF, Kelsoe J, O'Donovan MC, Furberg H. All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs. PLoS Genet. 2013 Apr; 9(4):e1003449. PMID: 23637621.
      View in: PubMed
    50. Andreassen OA, Thompson WK, Schork AJ, Ripke S, Mattingsdal M, Kelsoe J, Kendler KS, O'Donovan MC, Rujescu D, Werge T, Sklar P. Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate. PLoS Genet. 2013 Apr; 9(4):e1003455. PMID: 23637625; PMCID: PMC3636100.
    51. Kripke DF, Nievergelt CM, Tranah GJ, Murray SS, Rex KM, Grizas AP, Hahn EK, Lee HJ, Kelsoe J, Kline LE. FMR1, circadian genes and depression: suggestive associations or false discovery? J Circadian Rhythms. 2013 Mar 23; 11(1):3. PMID: 23521777; PMCID: PMC3627611.
    52. Greenwood TA. Genome-wide association study of irritable vs. elated mania suggests genetic differences between clinical subtypes of bipolar disorder. PLoS One. 2013; 8(1):e53804. PMID: 23326512; PMCID: PMC3542199.
    53. Greenwood TA, Joo EJ, Shekhtman T, Sadovnick AD, Remick RA, Keck PE, McElroy SL, Kelsoe J. Association of dopamine transporter gene variants with childhood ADHD features in bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2013 Mar; 162B(2):137-45. PMID: 23255304; PMCID: PMC3904300.
    54. Nissen S, Liang S, Shehktman T, Kelsoe J. Evidence for association of bipolar disorder to haplotypes in the 22q12.3 region near the genes stargazin, IFT27 and parvalbumin. Am J Med Genet B Neuropsychiatr Genet. 2012 Dec; 159B(8):941-50. PMID: 23038240.
      View in: PubMed
    55. Meier S, Mattheisen M, Vassos E, Strohmaier J, Treutlein J, Josef F, Breuer R, Degenhardt F, Mühleisen TW, Müller-Myhsok B, Steffens M, Schmael C, McMahon FJ. Genome-wide significant association between a 'negative mood delusions' dimension in bipolar disorder and genetic variation on chromosome 3q26.1. Transl Psychiatry. 2012 Sep 25; 2:e165. PMID: 23010768; PMCID: PMC3565205.
    56. Lee HJ, Woo HG, Greenwood TA, Kripke DF, Kelsoe J. A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder. J Affect Disord. 2013 Feb 20; 145(2):200-7. PMID: 22925353.
      View in: PubMed
    57. Sequeira A, Martin MV, Rollins B, Moon EA, Bunney WE, Macciardi F, Lupoli S, Smith EN, Kelsoe J, Magnan CN, van Oven M, Baldi P, Wallace DC, Vawter MP. Mitochondrial mutations and polymorphisms in psychiatric disorders. Front Genet. 2012; 3:103. PMID: 22723804; PMCID: PMC3379031.
    58. Greenwood TA, Akiskal HS, Akiskal KK. Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci. Biol Psychiatry. 2012 Aug 15; 72(4):303-10. PMID: 22365631; PMCID: PMC3925336.
    59. McCarthy MJ, Nievergelt CM, Kelsoe J, Welsh DK. A survey of genomic studies supports association of circadian clock genes with bipolar disorder spectrum illnesses and lithium response. PLoS One. 2012; 7(2):e32091. PMID: 22384149; PMCID: PMC3285204.
    60. Greenwood TA, Nievergelt CM, Sadovnick AD, Remick RA, Keck PE, McElroy SL, Shekhtman T, McKinney R, Kelsoe J. Further evidence for linkage of bipolar disorder to chromosomes 6 and 17 in a new independent pedigree series. Bipolar Disord. 2012 Feb; 14(1):71-9. PMID: 22329474; PMCID: PMC3965176.
    61. Malhotra D, McCarthy S, Michaelson JJ, Vacic V, Burdick KE, Yoon S, Cichon S, Corvin A, Gary S, Gershon ES, Gill M, Karayiorgou M, Kelsoe J, Krastoshevsky O, Krause V, Leibenluft E, Levy DL, Makarov V, Bhandari A, Malhotra AK, McMahon FJ, Nöthen MM, Potash JB, Rietschel M, Schulze TG, Sebat J. High frequencies of de novo CNVs in bipolar disorder and schizophrenia. Neuron. 2011 Dec 22; 72(6):951-63. PMID: 22196331.
      View in: PubMed
    62. Thorn CF, Leckband SG, Kelsoe J, Leeder JS, Müller DJ, Klein TE, Altman RB. PharmGKB summary: carbamazepine pathway. Pharmacogenet Genomics. 2011 Dec; 21(12):906-10. PMID: 21738081; PMCID: PMC3349991.
    63. Kripke DF, Nievergelt CM, Tranah GJ, Murray SS, McCarthy MJ, Rex KM, Parimi N, Kelsoe J. Polymorphisms in melatonin synthesis pathways: possible influences on depression. J Circadian Rhythms. 2011 Aug 09; 9:8. PMID: 21827647; PMCID: PMC3177871.
    64. Smith EN, Koller DL, Panganiban C, Szelinger S, Zhang P, Badner JA, Barrett TB, Berrettini WH, Bloss CS, Byerley W, Coryell W, Edenberg HJ, Foroud T, Gershon ES, Greenwood TA, Guo Y, Hipolito M, Keating BJ, Lawson WB, Liu C, Mahon PB, McInnis MG, McMahon FJ, McKinney R, Murray SS, Nievergelt CM, Nurnberger JI, Nwulia EA, Potash JB, Rice J, Schulze TG, Scheftner WA, Shilling PD, Zandi PP, Zöllner S, Craig DW, Schork NJ, Kelsoe J. Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes. PLoS Genet. 2011 Jun; 7(6):e1002134. PMID: 21738484; PMCID: PMC3128104.
    65. Fountoulakis KN, Kelsoe J, Akiskal H. Receptor targets for antidepressant therapy in bipolar disorder: an overview. J Affect Disord. 2012 May; 138(3):222-38. PMID: 21601292.
      View in: PubMed
    66. Lee HJ, Rex KM, Nievergelt CM, Kelsoe J, Kripke DF. Delayed sleep phase syndrome is related to seasonal affective disorder. J Affect Disord. 2011 Oct; 133(3):573-9. PMID: 21601293; PMCID: PMC3163003.
    67. Greenwood TA, Lazzeroni LC, Murray SS, Cadenhead KS, Calkins ME, Dobie DJ, Green MF, Gur RE, Gur RC, Hardiman G, Kelsoe J, Leonard S, Light GA, Nuechterlein KH, Olincy A, Radant AD, Schork NJ, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Swerdlow NR, Tsuang DW, Tsuang MT, Turetsky BI, Freedman R, Braff DL. Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia. Am J Psychiatry. 2011 Sep; 168(9):930-46. PMID: 21498463; PMCID: PMC3751972.
    68. Vacic V, McCarthy S, Malhotra D, Murray F, Chou HH, Peoples A, Makarov V, Yoon S, Bhandari A, Corominas R, Iakoucheva LM, Krastoshevsky O, Krause V, Larach-Walters V, Welsh DK, Craig D, Kelsoe J, Gershon ES, Leal SM, Dell Aquila M, Morris DW, Gill M, Corvin A, Insel PA, McClellan J, King MC, Karayiorgou M, Levy DL, DeLisi LE, Sebat J. Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia. Nature. 2011 Mar 24; 471(7339):499-503. PMID: 21346763; PMCID: PMC3351382.
    69. Belmonte Mahon P, Pirooznia M, Goes FS, Seifuddin F, Steele J, Lee PH, Huang J, Hamshere ML. Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2011 Apr; 156B(3):370-8. PMID: 21305692; PMCID: PMC3178836.
    70. Kelsoe J. Behavioural neuroscience: A gene for impulsivity. Nature. 2010 Dec 23; 468(7327):1049-50. PMID: 21179159.
      View in: PubMed
    71. McCarthy MJ, Leckband SG, Kelsoe J. Pharmacogenetics of lithium response in bipolar disorder. Pharmacogenomics. 2010 Oct; 11(10):1439-65. PMID: 21047205.
      View in: PubMed
    72. Yi Z, Fang Y, Yu S, Hong W, Wang Z, Yuan C, Jiang S, Kelsoe J, Wang Z. Association study of microsatellite markers on chromosome 22q11-13 with schizophrenia and mood disorder in Chinese Han population. Psychiatry Res. 2011 Apr 30; 186(2-3):465-6. PMID: 20692045.
      View in: PubMed
    73. Zhou X, Nie Z, Roberts A, Zhang D, Sebat J, Malhotra D, Kelsoe J, Geyer MA. Reduced NMDAR1 expression in the Sp4 hypomorphic mouse may contribute to endophenotypes of human psychiatric disorders. Hum Mol Genet. 2010 Oct 01; 19(19):3797-805. PMID: 20634195; PMCID: PMC2935857.
    74. Schulze TG, Alda M, Adli M, Akula N, Ardau R, Bui ET, Chillotti C, Cichon S, Czerski P, Del Zompo M, Detera-Wadleigh SD, Grof P, Gruber O, Hashimoto R, Hauser J, Hoban R, Iwata N, Kassem L, Kato T, Kittel-Schneider S, Kliwicki S, Kelsoe J, Kusumi I, Laje G, Leckband SG, Manchia M, Macqueen G, Masui T, Ozaki N, Perlis RH, Pfennig A, Piccardi P, Richardson S, Rouleau G, Reif A, Rybakowski JK, Sasse J, Schumacher J, Severino G, Smoller JW, Squassina A, Turecki G, Young LT, Yoshikawa T, Bauer M, McMahon FJ. The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment. Neuropsychobiology. 2010; 62(1):72-8. PMID: 20453537; PMCID: PMC2889682.
    75. Lavebratt C, Sjöholm LK, Soronen P, Paunio T, Vawter MP, Bunney WE, Adolfsson R, Forsell Y, Wu JC, Kelsoe J, Partonen T, Schalling M. CRY2 is associated with depression. PLoS One. 2010 Feb 24; 5(2):e9407. PMID: 20195522; PMCID: PMC2827563.
    76. Joo EJ, Greenwood TA, Schork N, McKinney RA, Sadovnick AD, Remick RA, Keck PE, McElroy SL, Kelsoe J. Suggestive evidence for linkage of ADHD features in bipolar disorder to chromosome 10p14. Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 05; 153B(1):260-8. PMID: 19603423.
      View in: PubMed
    77. McCarthy MJ, Barrett TB, Nissen S, Kelsoe J, Turner EE. Allele specific analysis of the ADRBK2 gene in lymphoblastoid cells from bipolar disorder patients. J Psychiatr Res. 2010 Mar; 44(4):201-8. PMID: 19766236; PMCID: PMC2830298.
    78. Zhou X, Tang W, Greenwood TA, Guo S, He L, Geyer MA, Kelsoe J. Transcription factor SP4 is a susceptibility gene for bipolar disorder. PLoS One. 2009; 4(4):e5196. PMID: 19401786; PMCID: PMC2674320.
    79. Wu JC, Kelsoe J, Schachat C, Bunney BG, DeModena A, Golshan S, Gillin JC, Potkin SG, Bunney WE. Rapid and sustained antidepressant response with sleep deprivation and chronotherapy in bipolar disorder. Biol Psychiatry. 2009 Aug 01; 66(3):298-301. PMID: 19358978.
      View in: PubMed
    80. Genomewide association studies: history, rationale, and prospects for psychiatric disorders. Am J Psychiatry. 2009 May; 166(5):540-56. PMID: 19339359.
      View in: PubMed
    81. Kripke DF, Nievergelt CM, Joo E, Shekhtman T, Kelsoe J. Circadian polymorphisms associated with affective disorders. J Circadian Rhythms. 2009 Jan 23; 7:2. PMID: 19166596; PMCID: PMC2661876.
    82. Liu L, Foroud T, Xuei X, Berrettini W, Byerley W, Coryell W, El-Mallakh R, Gershon ES, Kelsoe J, Lawson WB, MacKinnon DF, McInnis M, McMahon FJ, Murphy DL, Rice J, Scheftner W, Zandi PP, Lohoff FW, Niculescu AB, Meyer ET, Edenberg HJ, Nurnberger JI. Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder. Psychiatr Genet. 2008 Dec; 18(6):267-74. PMID: 19018231; PMCID: PMC2653694.
    83. Ross J, Berrettini W, Coryell W, Gershon ES, Badner JA, Kelsoe J, McInnis MG, McMahon FJ, Murphy DL, Nurnberger JI, Foroud T, Rice JP, Scheftner WB, Zandi P, Edenberg H, Byerley W. Genome-wide parametric linkage analyses of 644 bipolar pedigrees suggest susceptibility loci at chromosomes 16 and 20. Psychiatr Genet. 2008 Aug; 18(4):191-8. PMID: 18628681; PMCID: PMC4418612.
    84. Kripke DF, Rex KM, Ancoli-Israel S, Nievergelt CM, Klimecki W, Kelsoe J. Delayed sleep phase cases and controls. J Circadian Rhythms. 2008 Apr 29; 6:6. PMID: 18445295; PMCID: PMC2391143.
    85. Evans LM, Akiskal HS, Greenwood TA, Nievergelt CM, Keck PE, McElroy SL, Sadovnick AD, Remick RA, Schork NJ, Kelsoe J. Suggestive linkage of a chromosomal locus on 18p11 to cyclothymic temperament in bipolar disorder families. Am J Med Genet B Neuropsychiatr Genet. 2008 Apr 05; 147(3):326-32. PMID: 18081158.
      View in: PubMed
    86. Zhou X, Barrett TB, Kelsoe J. Promoter variant in the GRK3 gene associated with bipolar disorder alters gene expression. Biol Psychiatry. 2008 Jul 15; 64(2):104-10. PMID: 18359007.
      View in: PubMed
    87. Payne JL, MacKinnon DF, Mondimore FM, McInnis MG, Schweizer B, Zamoiski RB, McMahon FJ, Nurnberger JI, Rice JP, Scheftner W, Coryell W, Berrettini WH, Kelsoe J, Byerley W, Gershon ES, DePaulo JR, Potash JB. Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees. Bipolar Disord. 2008 Feb; 10(1):38-44. PMID: 18199240.
      View in: PubMed
    88. Barrett TB, Emberton JE, Nievergelt CM, Liang SG, Hauger RL, Eskin E, Schork NJ, Kelsoe J. Further evidence for association of GRK3 to bipolar disorder suggests a second disease mutation. Psychiatr Genet. 2007 Dec; 17(6):315-22. PMID: 18075471.
      View in: PubMed
    89. New models of collaboration in genome-wide association studies: the Genetic Association Information Network. Nat Genet. 2007 Sep; 39(9):1045-51. PMID: 17728769.
      View in: PubMed
    90. Guindalini C, Collier D, Laranjeira R, Barrett TB, Kelsoe J, Castelo A, Vallada H, Breen G. Association analysis of GRK3 gene promoter variants in cocaine abuse. Psychiatr Genet. 2007 Aug; 17(4):239-42. PMID: 17621168.
      View in: PubMed
    91. Goes FS, Zandi PP, Miao K, McMahon FJ, Steele J, Willour VL, Mackinnon DF, Mondimore FM, Schweizer B, Nurnberger JI, Rice JP, Scheftner W, Coryell W, Berrettini WH, Kelsoe J, Byerley W, Murphy DL, Gershon ES. Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33. Am J Psychiatry. 2007 Feb; 164(2):236-47. PMID: 17267786.
      View in: PubMed
    92. Bremer T, Diamond C, McKinney R, Shehktman T, Barrett TB, Herold C, Kelsoe J. The pharmacogenetics of lithium response depends upon clinical co-morbidity. Mol Diagn Ther. 2007; 11(3):161-70. PMID: 17570738.
      View in: PubMed
    93. Shilling PD, Kuczenski R, Segal DS, Barrett TB, Kelsoe J. Differential regulation of immediate-early gene expression in the prefrontal cortex of rats with a high vs low behavioral response to methamphetamine. Neuropsychopharmacology. 2006 Nov; 31(11):2359-67. PMID: 16855532.
      View in: PubMed
    94. Nievergelt CM, Kripke DF, Barrett TB, Burg E, Remick RA, Sadovnick AD, McElroy SL, Keck PE, Schork NJ, Kelsoe J. Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2006 Apr 05; 141B(3):234-41. PMID: 16528748; PMCID: PMC2651679.
    95. Guindalini C, Howard M, Haddley K, Laranjeira R, Collier D, Ammar N, Craig I, O'Gara C, Bubb VJ, Greenwood T, Kelsoe J, Asherson P, Murray RM, Castelo A, Quinn JP, Vallada H, Breen G. A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample. Proc Natl Acad Sci U S A. 2006 Mar 21; 103(12):4552-7. PMID: 16537431; PMCID: PMC1450209.
    96. Kimmel RJ, Kovacs I, Vrabel C, Wood B, Schalling M, Kelsoe J. Cosegregation of bipolar disorder and autosomal-dominant medullary cystic kidney disease in a large family. Am J Psychiatry. 2005 Oct; 162(10):1972-4. PMID: 16199849.
      View in: PubMed
    97. McQueen MB, Devlin B, Faraone SV, Nimgaonkar VL, Sklar P, Smoller JW, Abou Jamra R, Albus M, Bacanu SA, Baron M, Barrett TB, Berrettini W, Blacker D, Byerley W, Cichon S, Coryell W, Craddock N, Daly MJ, Depaulo JR, Edenberg HJ, Foroud T, Gill M, Gilliam TC, Hamshere M, Jones I, Jones L, Juo SH, Kelsoe J, Lambert D, Lange C, Lerer B, Liu J, Maier W, Mackinnon JD, McInnis MG, McMahon FJ, Murphy DL, Nothen MM, Nurnberger JI, Pato CN, Pato MT, Potash JB, Propping P, Pulver AE, Rice JP, Rietschel M, Scheftner W, Schumacher J, Segurado R, Van Steen K, Xie W, Zandi PP, Laird NM. Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. Am J Hum Genet. 2005 Oct; 77(4):582-95. PMID: 16175504; PMCID: PMC1275607.
    98. Mendlowicz MV, Jean-Louis G, Kelsoe J, Akiskal HS. A comparison of recovered bipolar patients, healthy relatives of bipolar probands, and normal controls using the short TEMPS-A. J Affect Disord. 2005 Mar; 85(1-2):147-51. PMID: 15780685.
      View in: PubMed
    99. Evans L, Akiskal HS, Keck PE, McElroy SL, Sadovnick AD, Remick RA, Kelsoe J. Familiality of temperament in bipolar disorder: support for a genetic spectrum. J Affect Disord. 2005 Mar; 85(1-2):153-68. PMID: 15780686.
      View in: PubMed
    100. Nievergelt CM, Kripke DF, Remick RA, Sadovnick AD, McElroy SL, Keck PE, Kelsoe J. Examination of the clock gene Cryptochrome 1 in bipolar disorder: mutational analysis and absence of evidence for linkage or association. Psychiatr Genet. 2005 Mar; 15(1):45-52. PMID: 15722957.
      View in: PubMed
    101. Akiskal HS, Mendlowicz MV, Jean-Louis G, Rapaport MH, Kelsoe J, Gillin JC, Smith TL. TEMPS-A: validation of a short version of a self-rated instrument designed to measure variations in temperament. J Affect Disord. 2005 Mar; 85(1-2):45-52. PMID: 15780675.
      View in: PubMed
    102. Mendlowicz MV, Akiskal HS, Kelsoe J, Rapaport MH, Jean-Louis G, Gillin JC. Temperament in the clinical differentiation of depressed bipolar and unipolar major depressive patients. J Affect Disord. 2005 Feb; 84(2-3):219-23. PMID: 15708419.
      View in: PubMed
    103. Haynes PL, McQuaid JR, Kelsoe J, Rapaport M, Gillin JC. Affective state and EEG sleep profile in response to rapid tryptophan depletion in recently recovered nonmedicated depressed individuals. J Affect Disord. 2004 Dec; 83(2-3):253-62. PMID: 15555723.
      View in: PubMed
    104. Kelsoe J. Genomics and the Human Genome Project: implications for psychiatry. Int Rev Psychiatry. 2004 Nov; 16(4):294-300. PMID: 16194762.
      View in: PubMed
    105. Cichon S, Buervenich S, Kirov G, Akula N, Dimitrova A, Green E, Schumacher J, Klopp N, Becker T, Ohlraun S, Schulze TG, Tullius M, Gross MM, Jones L, Krastev S, Nikolov I, Hamshere M, Jones I, Czerski PM, Leszczynska-Rodziewicz A, Kapelski P, Bogaert AV, Illig T, Hauser J, Maier W, Berrettini W, Byerley W, Coryell W, Gershon ES, Kelsoe J, McInnis MG, Murphy DL, Nurnberger JI, Reich T, Scheftner W, O'Donovan MC, Propping P, Owen MJ, Rietschel M, Nöthen MM, McMahon FJ, Craddock N. Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin. Nat Genet. 2004 Aug; 36(8):783-4; author reply 784-5. PMID: 15284840.
      View in: PubMed
    106. Schulze TG, Buervenich S, Badner JA, Steele CJ, Detera-Wadleigh SD, Dick D, Foroud T, Cox NJ, MacKinnon DF, Potash JB, Berrettini WH, Byerley W, Coryell W, DePaulo JR, Gershon ES, Kelsoe J, McInnis MG, Murphy DL, Reich T, Scheftner W, Nurnberger JI, McMahon FJ. Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees. Biol Psychiatry. 2004 Jul 01; 56(1):18-23. PMID: 15219468.
      View in: PubMed
    107. Caligiuri MP, Gentili V, Eberson S, Kelsoe J, Rapaport M, Gillin JC. A quantitative neuromotor predictor of antidepressant non-response in patients with major depression. J Affect Disord. 2003 Nov; 77(2):135-41. PMID: 14607390.
      View in: PubMed
    108. Greenwood TA, Kelsoe J. Promoter and intronic variants affect the transcriptional regulation of the human dopamine transporter gene. Genomics. 2003 Nov; 82(5):511-20. PMID: 14559208.
      View in: PubMed
    109. Segurado R, Detera-Wadleigh SD, Levinson DF, Lewis CM, Gill M, Nurnberger JI, Craddock N, DePaulo JR, Baron M, Gershon ES, Ekholm J, Cichon S, Turecki G, Claes S, Kelsoe J, Schofield PR, Badenhop RF, Morissette J, Coon H, Blackwood D, McInnes LA, Foroud T, Edenberg HJ, Reich T, Rice JP, Goate A, McInnis MG, McMahon FJ, Badner JA, Goldin LR, Bennett P, Willour VL, Zandi PP, Liu J, Gilliam C, Juo SH, Berrettini WH, Yoshikawa T, Peltonen L, Lönnqvist J, Nöthen MM, Schumacher J, Windemuth C, Rietschel M, Propping P, Maier W, Alda M, Grof P, Rouleau GA, Del-Favero J, Van Broeckhoven C, Mendlewicz J, Adolfsson R, Spence MA, Luebbert H, Adams LJ, Donald JA, Mitchell PB, Barden N, Shink E, Byerley W, Muir W, Visscher PM, Macgregor S, Gurling H, Kalsi G, McQuillin A, Escamilla MA, Reus VI, Leon P, Freimer NB, Ewald H, Kruse TA, Mors O, Radhakrishna U, Blouin JL, Antonarakis SE, Akarsu N. Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder. Am J Hum Genet. 2003 Jul; 73(1):49-62. PMID: 12802785; PMCID: PMC1180589.
    110. Dick DM, Foroud T, Flury L, Bowman ES, Miller MJ, Rau NL, Moe PR, Samavedy N, El-Mallakh R, Manji H, Glitz DA, Meyer ET, Smiley C, Hahn R, Widmark C, McKinney R, Sutton L, Ballas C, Grice D, Berrettini W, Byerley W, Coryell W, DePaulo R, MacKinnon DF, Gershon ES, Kelsoe J, McMahon FJ, McInnis M, Murphy DL, Reich T, Scheftner W, Nurnberger JI. Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative. Am J Hum Genet. 2003 Jul; 73(1):107-14. PMID: 12772088; PMCID: PMC1180573.
    111. Schuckit MA, Kelsoe J, Braff DL, Wilhelmsen KC. Some possible genetic parallels across alcoholism, bipolar disorder and schizophrenia. J Stud Alcohol. 2003 Mar; 64(2):157-9. PMID: 12713187.
      View in: PubMed
    112. Landolt HP, Kelsoe J, Rapaport MH, Gillin JC. Rapid tryptophan depletion reverses phenelzine-induced suppression of REM sleep. J Sleep Res. 2003 Mar; 12(1):13-8. PMID: 12603782.
      View in: PubMed
    113. Kelsoe J. Arguments for the genetic basis of the bipolar spectrum. J Affect Disord. 2003 Jan; 73(1-2):183-97. PMID: 12507751.
      View in: PubMed
    114. Liang SG, Sadovnick AD, Remick RA, Keck PE, McElroy SL, Kelsoe J. A linkage disequilibrium study of bipolar disorder and microsatellite markers on 22q13. Psychiatr Genet. 2002 Dec; 12(4):231-5. PMID: 12454528.
      View in: PubMed
    115. Evans L, Golshan S, Kelsoe J, Rapaport M, Resovsky K, Sutton L, Gillin JC. Effects of rapid tryptophan depletion on sleep electroencephalogram and mood in subjects with partially remitted depression on bupropion. Neuropsychopharmacology. 2002 Dec; 27(6):1016-26. PMID: 12464458.
      View in: PubMed
    116. Kelsoe J, Niculescu AB. Finding genes for bipolar disorder in the functional genomics era: from convergent functional genomics to phenomics and back. CNS Spectr. 2002 Mar; 7(3):215-6, 223-6. PMID: 15211285.
      View in: PubMed
    117. Shilling PD, Kelsoe J. Functional genomics approaches to understanding brain disorders. Pharmacogenomics. 2002 Jan; 3(1):31-45. PMID: 11966401.
      View in: PubMed
    118. Dow BM, Kelsoe J, Gillin JC. Sleep and dreams in Vietnam PTSD and depression. Biol Psychiatry. 1996 Jan 01; 39(1):42-50. PMID: 8719125.
      View in: PubMed
    119. Rapaport MH, Thompson PM, Kelsoe J, Golshan S, Judd LL, Gillin JC. Gender differences in outpatient research subjects with affective disorders: a comparison of descriptive variables. J Clin Psychiatry. 1995 Feb; 56(2):67-72. PMID: 7852255.
      View in: PubMed
    120. Sutin EL, Shiromani PJ, Kelsoe J, Storch FI, Gillin JC. Rapid-eye movement sleep and muscarinic receptor binding in rats are augmented during withdrawal from chronic scopolamine treatment. Life Sci. 1986 Dec 22; 39(25):2419-27. PMID: 3796202.
      View in: PubMed
    121. Kelsoe J, Gillin JC, Janowsky DS, Brown JH, Risch SC, Lumkin B. Specific [3H]-N-methyl scopolamine binding without cholinergic function in cultured adult skin fibroblasts. Life Sci. 1986 Apr 14; 38(15):1399-408. PMID: 3007910.
      View in: PubMed
    122. Gillin JC, Kelsoe J, Kaufman CA, Kleinman JE, Risch SC, Janowsky DS. Muscarinic receptor density in skin fibroblasts and autopsied brain tissue in affective disorder. Ann N Y Acad Sci. 1986; 487:143-9. PMID: 3471159.
      View in: PubMed