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Mark Lawson

Title(s)Professor, In Residence, Reproductive Medicine
SchoolHealth Sciences
Phone858-822-4128
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    Collapse Biography 
    Collapse Education and Training
    San Diego Sate UniversityB.S.1986Microbiology
    University of California, IrvinePh.D.1991Microbiology and Molecular Genetics
    Collapse Awards and Honors
    UC Irvine1986  - 1987University Fellowship in Biological Science
    UC Irvine1987  - 1991Trainee, National Canceer Institute
    UCSD1992  - 1993Ford Foundation/National Academy of Sciences Postdocotoral Fellowship
    UCSD1994  - 1996University of California President's Postdoctoral Fellowship
    UCSD2006Equal Opportunity/Affirmative Action and Diversity Award
    UCSD2014Equal Opportunity/Affirmative Action and Diversity Award

    Collapse Research 
    Collapse Research Activities and Funding
    Endocrine Network for Undergraduate Research and Carrier Development Opportunitie
    NIH/NIGMS T36GM095349Mar 1, 2011 - Feb 29, 2016
    Role: Principal Investigator
    Mentoring Young Minds to Increase Diversity in the Biomedical Research
    NIH/NIGMS R25GM083275Mar 1, 2008 - Jan 31, 2023
    Role: Co-Principal Investigator
    Insulin Signaling in the Anterior Pituitary
    NIH/NIDDK R21DK068167Mar 1, 2005 - Feb 28, 2008
    Role: Principal Investigator
    Mechanisms of Response to GnRH Receptor Signaling
    NIH/NICHD K02HD040803Sep 11, 2001 - Aug 31, 2006
    Role: Principal Investigator
    GnRH Signaling Mechanisms in the Pituitary Gonadotrope
    NIH/NICHD R01HD037568Mar 1, 2000 - Jun 30, 2015
    Role: Principal Investigator
    GATA FACTORS IN ENDOCRINE DEVELOPMENT
    NIH/NIDDK R03DK052284Sep 30, 1996 - Aug 31, 1999
    Role: Principal Investigator
    Center for Reproductive Science and Medicine
    NIH/NICHD P50HD012303Dec 1, 1978 - Mar 31, 2021
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Terasaka T, Kim T, Dave H, Gangapurkar B, Nicholas DA, Muñoz O, Terasaka E, Li D, Lawson MA. The RNA-binding Protein ELAVL1 Regulates GnRH Receptor Expression and the Response to GnRH. Endocrinology. 2019 Jun 12. PMID: 31188427.
      View in: PubMed
    2. Homer MV, Toloubeydokhti T, Lawson MA, Garzo G, Duleba AJ, Chang RJ. Individual 17-Hydroxyprogesterone Responses to hCG Are Not Correlated With Follicle Size in Polycystic Ovary Syndrome. J Endocr Soc. 2019 Apr 01; 3(4):687-698. PMID: 30918916.
      View in: PubMed
    3. Monahan K, Coffin S, Lawson M, Saliba L, Rutherford R, Brittain E. Pulmonary transit time from contrast echocardiography and cardiac magnetic resonance imaging: Comparison between modalities and the impact of region of interest characteristics. Echocardiography. 2019 01; 36(1):119-124. PMID: 30488494.
      View in: PubMed
    4. Yang S, O'Leary J, Lawson MA. A Young Man With Cardiomegaly and Edema. JAMA Cardiol. 2018 Aug 01; 3(8):777-778. PMID: 29800038.
      View in: PubMed
    5. Bradham WS, Bell SP, Huang S, Harrell FE, Adkisson DW, Lawson MA, Sawyer DB, Ooi H, Kronenberg MW. Timing of Left Ventricular Remodeling in Nonischemic Dilated Cardiomyopathy. Am J Med Sci. 2018 Sep; 356(3):262-267. PMID: 30286821.
      View in: PubMed
    6. Bradham W, Ormseth MJ, Elumogo C, Palanisamy S, Liu CY, Lawson MA, Soslow JH, Kawel-Boehm N, Bluemke DA, Stein CM. Absence of Fibrosis and Inflammation by Cardiac Magnetic Resonance Imaging in Rheumatoid Arthritis Patients with Low to Moderate Disease Activity. J Rheumatol. 2018 Aug; 45(8):1078-1084. PMID: 29657146.
      View in: PubMed
    7. Li S, Mbong EF, John DT, Terasaka T, Li D, Lawson MA. Induction of Stress Signaling In Vitro and Suppression of Gonadotropin Secretion by Free Fatty Acids in Female Mouse Gonadotropes. Endocrinology. 2018 02 01; 159(2):1074-1087. PMID: 29315384.
      View in: PubMed
    8. Terasaka T, Adakama ME, Li S, Kim T, Terasaka E, Li D, Lawson MA. Reactive Oxygen Species Link Gonadotropin-Releasing Hormone Receptor Signaling Cascades in the Gonadotrope. Front Endocrinol (Lausanne). 2017; 8:286. PMID: 29163358.
      View in: PubMed
    9. Bradham WS, Bell SP, Adkisson DW, Smith HM, Harrell FE, Lawson MA, Ooi H, Sawyer DB, Kronenberg MW. Myocardial T1 Measurement Predicts Beneficial LV Remodeling After Long-Term Heart Failure Therapy. J Card Fail. 2017 Mar; 23(3):262-265. PMID: 27940336.
      View in: PubMed
    10. Soslow JH, Damon SM, Crum K, Lawson MA, Slaughter JC, Xu M, Arai AE, Sawyer DB, Parra DA, Damon BM, Markham LW. Increased myocardial native T1 and extracellular volume in patients with Duchenne muscular dystrophy. J Cardiovasc Magn Reson. 2016 Jan 21; 18:5. PMID: 26795569; PMCID: PMC4722665.
    11. Montgomery JA, Abdallah W, Yoneda ZT, Brittain E, Aznaurov SG, Parvez B, Adkins K, Whalen SP, Estrada JC, Shen S, Crossley GH, Kanagasundram A, Saavedra P, Ellis CR, Lawson M, Darbar D, Shoemaker MB. Measurement of diffuse ventricular fibrosis with myocardial T1 in patients with atrial fibrillation. J Arrhythm. 2016 Feb; 32(1):51-6. PMID: 26949431.
      View in: PubMed
    12. Kim T, Lawson MA. GnRH Regulates Gonadotropin Gene Expression Through NADPH/Dual Oxidase-Derived Reactive Oxygen Species. Endocrinology. 2015 Jun; 156(6):2185-99. PMID: 25849727; PMCID: PMC4430611.
    13. Cook-Andersen H, Chuan SS, Maas K, Rosencrantz MA, Su HI, Lawson M, Mason HD, Chang RJ. Lack of Serum anti-Mullerian hormone responses after recombinant human chorionic gonadotropin stimulation in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2015 Jan; 100(1):251-7. PMID: 25303490; PMCID: PMC4283023.
    14. Lawson MA, Bell SP, Adkisson DW, Wang L, Ooi H, Sawyer DB, Kronenberg MW. High reproducibility of adenosine stress cardiac MR myocardial perfusion imaging in patients with non-ischaemic dilated cardiomyopathy. BMJ Open. 2014 Dec 16; 4(12):e005984. PMID: 25515841.
      View in: PubMed
    15. Bell SP, Adkisson DW, Lawson MA, Wang L, Ooi H, Sawyer DB, Kronenberg MW. Antifailure therapy including spironolactone improves left ventricular energy supply-demand relations in nonischemic dilated cardiomyopathy. J Am Heart Assoc. 2014 Aug 27; 3(4). PMID: 25164945; PMCID: PMC4310370.
    16. Soslow JH, Damon BM, Saville BR, Lu Z, Burnette WB, Lawson MA, Parra DA, Sawyer DB, Markham LW. Evaluation of post-contrast myocardial t1 in duchenne muscular dystrophy using cardiac magnetic resonance imaging. Pediatr Cardiol. 2015 Jan; 36(1):49-56. PMID: 25070387; PMCID: PMC4439095.
    17. Chen B, Siderovski DP, Neubig RR, Lawson MA, Trejo J. Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins. J Biol Chem. 2014 Jan 17; 289(3):1580-91. PMID: 24297163; PMCID: PMC3894338.
    18. Bell SP, Adkisson DW, Ooi H, Sawyer DB, Lawson MA, Kronenberg MW. Impairment of subendocardial perfusion reserve and oxidative metabolism in nonischemic dilated cardiomyopathy. J Card Fail. 2013 Dec; 19(12):802-10. PMID: 24331202; PMCID: PMC3945036.
    19. Do MT, Kim T, He F, Dave H, Intriago RE, Astorga UA, Jain S, Lawson MA. Polyribosome and ribonucleoprotein complex redistribution of mRNA induced by GnRH involves both EIF2AK3 and MAPK signaling. Mol Cell Endocrinol. 2014 Jan 25; 382(1):346-357. PMID: 24161835.
      View in: PubMed
    20. Kim T, Do MH, Lawson MA. Translational control of gene expression in the gonadotrope. Mol Cell Endocrinol. 2014 Mar 25; 385(1-2):78-87. PMID: 24035865; PMCID: PMC4009948.
    21. Terasaka T, Otsuka F, Tsukamoto N, Nakamura E, Inagaki K, Toma K, Ogura-Ochi K, Glidewell-Kenney C, Lawson MA, Makino H. Mutual interaction of kisspeptin, estrogen and bone morphogenetic protein-4 activity in GnRH regulation by GT1-7 cells. Mol Cell Endocrinol. 2013 Dec 05; 381(1-2):8-15. PMID: 23880664; PMCID: PMC4079587.
    22. Lawson MA. Commentary: meeting the challenge to train the next generation of endocrinologists: filling, diversifying, and plugging leaks in the career pipeline. Endocrinology. 2013 Aug; 154(8):2581-5. PMID: 23709087; PMCID: PMC3713218.
    23. Park SJ, Kim TS, Park CK, Lee SH, Kim JM, Lee KS, Lee IK, Park JW, Lawson MA, Lee DS. hCG-induced endoplasmic reticulum stress triggers apoptosis and reduces steroidogenic enzyme expression through activating transcription factor 6 in Leydig cells of the testis. J Mol Endocrinol. 2013 Apr; 50(2):151-66. PMID: 23256993; PMCID: PMC4111658.
    24. Odiete O, Nagendra R, Lawson MA, Okafor H. Biventricular noncompaction cardiomyopathy in a patient presenting with new onset seizure: case report. Case Rep Cardiol. 2012; 2012:924865. PMID: 24826276; PMCID: PMC4008239.
    25. Brittain EL, Hemnes AR, Keebler M, Lawson M, Byrd BF, Disalvo T. Right ventricular plasticity and functional imaging. Pulm Circ. 2012 Jul; 2(3):309-26. PMID: 23130100; PMCID: PMC3487300.
    26. Takeda M, Otsuka F, Takahashi H, Inagaki K, Miyoshi T, Tsukamoto N, Makino H, Lawson MA. Interaction between gonadotropin-releasing hormone and bone morphogenetic protein-6 and -7 signaling in LßT2 gonadotrope cells. Mol Cell Endocrinol. 2012 Jan 02; 348(1):147-54. PMID: 21846488; PMCID: PMC3719407.
    27. Mistry DS, Tsutsumi R, Fernandez M, Sharma S, Cardenas SA, Lawson MA, Webster NJ. Gonadotropin-releasing hormone pulse sensitivity of follicle-stimulating hormone-beta gene is mediated by differential expression of positive regulatory activator protein 1 factors and corepressors SKIL and TGIF1. Mol Endocrinol. 2011 Aug; 25(8):1387-403. PMID: 21659477; PMCID: PMC3146254.
    28. Petersen JW, Forder JR, Thomas JD, Moyé LA, Lawson M, Loghin C, Traverse JH, Baraniuk S, Silva G, Pepine CJ. Quantification of myocardial segmental function in acute and chronic ischemic heart disease and implications for cardiovascular cell therapy trials: a review from the NHLBI-Cardiovascular Cell Therapy Research Network. JACC Cardiovasc Imaging. 2011 Jun; 4(6):671-9. PMID: 21679903; PMCID: PMC3157843.
    29. Nguyen KA, Intriago RE, Upadhyay HC, Santos SJ, Webster NJ, Lawson MA. Modulation of gonadotropin-releasing hormone-induced extracellular signal-regulated kinase activation by dual-specificity protein phosphatase 1 in LbetaT2 gonadotropes. Endocrinology. 2010 Oct; 151(10):4882-93. PMID: 20685880; PMCID: PMC2946148.
    30. Park AS, Lawson MA, Chuan SS, Oberfield SE, Hoeger KM, Witchel SF, Chang RJ. Serum anti-mullerian hormone concentrations are elevated in oligomenorrheic girls without evidence of hyperandrogenism. J Clin Endocrinol Metab. 2010 Apr; 95(4):1786-92. PMID: 20150576; PMCID: PMC2853993.
    31. Otani H, Otsuka F, Takeda M, Mukai T, Terasaka T, Miyoshi T, Inagaki K, Suzuki J, Ogura T, Lawson MA, Makino H. Regulation of GNRH production by estrogen and bone morphogenetic proteins in GT1-7 hypothalamic cells. J Endocrinol. 2009 Oct; 203(1):87-97. PMID: 19635757; PMCID: PMC2768486.
    32. Navratil AM, Song H, Hernandez JB, Cherrington BD, Santos SJ, Low JM, Do MH, Lawson MA. Insulin augments gonadotropin-releasing hormone induction of translation in LbetaT2 cells. Mol Cell Endocrinol. 2009 Nov 13; 311(1-2):47-54. PMID: 19632296; PMCID: PMC2739255.
    33. Ahmad RM, Umakanthan R, Lawson M, Leacche M, Solenkova NV, Byrne JG. Nonsurgical management of traumatic cardiac pseudoaneurysms. J Thorac Cardiovasc Surg. 2010 Apr; 139(4):e83-5. PMID: 19660408.
      View in: PubMed
    34. Hundley WG, Bluemke D, Bogaert JG, Friedrich MG, Higgins CB, Lawson MA, McConnell MV, Raman SV, van Rossum AC, Flamm S, Kramer CM, Nagel E, Neubauer S. Society for Cardiovascular Magnetic Resonance guidelines for reporting cardiovascular magnetic resonance examinations. J Cardiovasc Magn Reson. 2009 Mar 03; 11:5. PMID: 19257889.
      View in: PubMed
    35. Do MH, Santos SJ, Lawson MA. GNRH induces the unfolded protein response in the LbetaT2 pituitary gonadotrope cell line. Mol Endocrinol. 2009 Jan; 23(1):100-12. PMID: 18974261; PMCID: PMC2646596.
    36. Feng J, Lawson MA, Melamed P. A proteomic comparison of immature and mature mouse gonadotrophs reveals novel differentially expressed nuclear proteins that regulate gonadotropin gene transcription and RNA splicing. Biol Reprod. 2008 Sep; 79(3):546-61. PMID: 18480465; PMCID: PMC2574604.
    37. Lawson MA, Jain S, Sun S, Patel K, Malcolm PJ, Chang RJ. Evidence for insulin suppression of baseline luteinizing hormone in women with polycystic ovarian syndrome and normal women. J Clin Endocrinol Metab. 2008 Jun; 93(6):2089-96. PMID: 18334581; PMCID: PMC2435648.
    38. O'Connor JC, Lawson MA, André C, Moreau M, Lestage J, Castanon N, Kelley KW, Dantzer R. Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice. Mol Psychiatry. 2009 May; 14(5):511-22. PMID: 18195714.
      View in: PubMed
    39. Lawson MA, Tsutsumi R, Zhang H, Talukdar I, Butler BK, Santos SJ, Mellon PL, Webster NJ. Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2. Mol Endocrinol. 2007 May; 21(5):1175-91. PMID: 17299135; PMCID: PMC2932486.
    40. Zhang H, Bailey JS, Coss D, Lin B, Tsutsumi R, Lawson MA, Mellon PL, Webster NJ. Activin modulates the transcriptional response of LbetaT2 cells to gonadotropin-releasing hormone and alters cellular proliferation. Mol Endocrinol. 2006 Nov; 20(11):2909-30. PMID: 16772531; PMCID: PMC2673912.
    41. Nguyen KA, Santos SJ, Kreidel MK, Diaz AL, Rey R, Lawson MA. Acute regulation of translation initiation by gonadotropin-releasing hormone in the gonadotrope cell line LbetaT2. Mol Endocrinol. 2004 May; 18(5):1301-12. PMID: 14752057.
      View in: PubMed
    42. Patel K, Coffler MS, Dahan MH, Yoo RY, Lawson MA, Malcom PJ, Chang RJ. Increased luteinizing hormone secretion in women with polycystic ovary syndrome is unaltered by prolonged insulin infusion. J Clin Endocrinol Metab. 2003 Nov; 88(11):5456-61. PMID: 14602789.
      View in: PubMed
    43. Vasilyev VV, Lawson MA, Dipaolo D, Webster NJ, Mellon PL. Different signaling pathways control acute induction versus long-term repression of LHbeta transcription by GnRH. Endocrinology. 2002 Sep; 143(9):3414-26. PMID: 12193554; PMCID: PMC2932485.
    44. Liu S, Ogilvie KM, Klausing K, Lawson MA, Jolley D, Li D, Bilakovics J, Pascual B, Hein N, Urcan M, Leibowitz MD. Mechanism of selective retinoid X receptor agonist-induced hypothyroidism in the rat. Endocrinology. 2002 Aug; 143(8):2880-5. PMID: 12130551.
      View in: PubMed
    45. Lawson MA, Macconell LA, Kim J, Powl BT, Nelson SB, Mellon PL. Neuron-specific expression in vivo by defined transcription regulatory elements of the GnRH gene. Endocrinology. 2002 Apr; 143(4):1404-12. PMID: 11897697.
      View in: PubMed
    46. Lawson MA, Li D, Glidewell-Kenney CA, López FJ. Androgen responsiveness of the pituitary gonadotrope cell line LbetaT2. J Endocrinol. 2001 Sep; 170(3):601-7. PMID: 11524240.
      View in: PubMed
    47. Sosnowski R, Mellon PL, Lawson MA. Activation of translation in pituitary gonadotrope cells by gonadotropin-releasing hormone. Mol Endocrinol. 2000 Nov; 14(11):1811-9. PMID: 11075814.
      View in: PubMed
    48. Nelson SB, Lawson MA, Kelley CG, Mellon PL. Neuron-specific expression of the rat gonadotropin-releasing hormone gene is conferred by interactions of a defined promoter element with the enhancer in GT1-7 cells. Mol Endocrinol. 2000 Sep; 14(9):1509-22. PMID: 10976927.
      View in: PubMed
    49. MacConell LA, Lawson MA, Mellon PL, Roberts VJ. Activin A regulation of gonadotropin-releasing hormone synthesis and release in vitro. Neuroendocrinology. 1999 Oct; 70(4):246-54. PMID: 10529619.
      View in: PubMed
    50. Lawson MA, Mellon PL. Expression of GATA-4 in migrating gonadotropin-releasing neurons of the developing mouse. Mol Cell Endocrinol. 1998 May 25; 140(1-2):157-61. PMID: 9722184.
      View in: PubMed
    51. Lawson MA, Buhain AR, Jovenal JC, Mellon PL. Multiple factors interacting at the GATA sites of the gonadotropin-releasing hormone neuron-specific enhancer regulate gene expression. Mol Endocrinol. 1998 Mar; 12(3):364-77. PMID: 9514154.
      View in: PubMed
    52. Kaplan AM, Chen K, Lawson MA, Wodrich DL, Bonstelle CT, Reiman EM. Positron emission tomography in children with neurofibromatosis-1. J Child Neurol. 1997 Nov; 12(8):499-506. PMID: 9430315.
      View in: PubMed
    53. Lawson MA, Johnson LL, Coghlan L, Alami M, Tauxe EL, Reinert SE, Singleton R, Pohost GM. Correlation of thallium uptake with left ventricular wall thickness by cine magnetic resonance imaging in patients with acute and healed myocardial infarcts. Am J Cardiol. 1997 Aug 15; 80(4):434-41. PMID: 9285654.
      View in: PubMed
    54. Lawson MA, Whyte DB, Mellon PL. GATA factors are essential for activity of the neuron-specific enhancer of the gonadotropin-releasing hormone gene. Mol Cell Biol. 1996 Jul; 16(7):3596-605. PMID: 8668176.
      View in: PubMed
    55. Lawson MA, Blackwell GG, Davis ND, Roney M, Dell'Italia LJ, Pohost GM. Accuracy of biplane long-axis left ventricular volume determined by cine magnetic resonance imaging in patients with regional and global dysfunction. Am J Cardiol. 1996 May 15; 77(12):1098-104. PMID: 8644665.
      View in: PubMed
    56. Whyte DB, Lawson MA, Belsham DD, Eraly SA, Bond CT, Adelman JP, Mellon PL. A neuron-specific enhancer targets expression of the gonadotropin-releasing hormone gene to hypothalamic neurosecretory neurons. Mol Endocrinol. 1995 Apr; 9(4):467-77. PMID: 7659090.
      View in: PubMed
    57. Lawson MA, Whyte DB, Eraly SA, Mellon PL. Hypothalamus-specific regulation of gonadotropin-releasing hormone gene expression. Recent Prog Horm Res. 1995; 50:459-63. PMID: 7740182.
      View in: PubMed
    58. Nichols TL, Lawson MA, Mirvis DM. Determination of cardiac equivalent generator properties using a numerical expansion method. J Electrocardiol. 1987 Nov; 20(5):352-6. PMID: 3430103.
      View in: PubMed