Mark Lawson

Title(s)	Professor In Residence, Ob/Gyn & Reproductive sciences
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Biography

Education and Training

San Diego Sate University	B.S.	1986	Microbiology
University of California, Irvine	Ph.D.	1991	Microbiology and Molecular Genetics

Awards and Honors

UC Irvine	1986 -	1987	University Fellowship in Biological Science
UC Irvine	1987 -	1991	Trainee, National Canceer Institute
UCSD	1992 -	1993	Ford Foundation/National Academy of Sciences Postdocotoral Fellowship
UCSD	1994 -	1996	University of California President's Postdoctoral Fellowship
UCSD	2006		Equal Opportunity/Affirmative Action and Diversity Award
UCSD	2014		Equal Opportunity/Affirmative Action and Diversity Award

Overview

Websites

	Departmental Website
	Lawson Lab

In The News

	New Faculty Director for Postdoctoral Scholar Education and Training (01/07/2016)
	New Director Takes the Helm (10/01/2015)
	20th Annual Diversity Awwards (03/05/2015)
	Leaps of Faith (01/01/2015)
	Coalition of Graduate Programs Support Diversity (10/23/2014)
	Coalition of UC San Diego Graduate Programs Supports Campus Commitment to Recruiting Diverse Students (10/23/2014)
	Research Spotlight (02/01/2013)

Research

Research Activities and Funding

Endocrine Network for Undergraduate Research and Carrier Development Opportunitie
NIH T36GM095349Mar 1, 2011 - Feb 28, 2017
Role: Principal Investigator

Mentoring Young Minds to Increase Diversity in the Biomedical Research
NIH R25GM083275Mar 1, 2008 - Jan 31, 2023
Role: Co-Principal Investigator

Insulin Signaling in the Anterior Pituitary
NIH R21DK068167Mar 1, 2005 - Feb 28, 2008
Role: Principal Investigator

Mechanisms of Response to GnRH Receptor Signaling
NIH K02HD040803Sep 11, 2001 - Aug 31, 2006
Role: Principal Investigator

GnRH Signaling Mechanisms in the Pituitary Gonadotrope
NIH R01HD037568Mar 1, 2000 - Jun 30, 2015
Role: Principal Investigator

GATA FACTORS IN ENDOCRINE DEVELOPMENT
NIH R03DK052284Sep 30, 1996 - Aug 31, 1999
Role: Principal Investigator

Center for Reproductive Science and Medicine
NIH P50HD012303Dec 1, 1978 - Mar 31, 2021
Role: Co-Investigator

ORNG Applications

Featured Publications

Featured Videos

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Lipopolysaccharide-induced chronic inflammation increases female serum gonadotropins and shifts the pituitary transcriptomic landscape. Front Endocrinol (Lausanne). 2023; 14:1279878. Garcia C, Velez LM, Ujagar N, Del Mundo Z, Nguyen T, Fox C, Mark A, Fisch KM, Lawson MA, Duleba AJ, Seldin MM, Nicholas DA. PMID: 38260148; PMCID: PMC10801245.

View in: PubMed Mentions: 2 Fields:
End Endocrinology
Translation:Animals Cells
The Culture and Justice Quorum at University of California, San Diego: A Departmental Approach to Dismantling Structural Racism. Acad Med. 2023 08 01; 98(8):906-911. Ha D, Ghebrendrias S, Meadows A, LaCoursiere DY, Lewis A, Lawson M, Morales M, Gyamfi-Bannerman C, Brubaker L. PMID: 36862643.

View in: PubMed Mentions: Fields:
Edu Education
Translation:Humans
aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis. Proc Natl Acad Sci U S A. 2021 12 07; 118(49). Molinar-Inglis O, Birch CA, Nicholas D, Orduña-Castillo L, Cisneros-Aguirre M, Patwardhan A, Chen B, Grimsey NJ, Coronel LJ, Lin H, Gomez Menzies PK, Lawson MA, Patel HH, Trejo J. PMID: 34873055; PMCID: PMC8670512.

View in: PubMed Mentions: 8 Fields:
Sci Science
Translation:Humans Cells
Androgen Suppresses In Vivo and In Vitro LH Pulse Secretion and Neural Kiss1 and Tac2 Gene Expression in Female Mice. Endocrinology. 2020 12 01; 161(12). Esparza LA, Terasaka T, Lawson MA, Kauffman AS. PMID: 33075809; PMCID: PMC7671291.

View in: PubMed Mentions: 8 Fields:
End Endocrinology
Translation:Animals Cells
GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes. Sci Rep. 2020 08 03; 10(1):13063. Nicholas DA, Knight VS, Tonsfeldt KJ, Terasaka T, Molinar-Inglis O, Stephens SBZ, Trejo J, Kauffman AS, Mellon PL, Lawson MA. PMID: 32747664; PMCID: PMC7400764.

View in: PubMed Mentions: 3 Fields:
Sci Science
Translation:Animals Cells
SRXN1 Is Necessary for Resolution of GnRH-Induced Oxidative Stress and Induction of Gonadotropin Gene Expression. Endocrinology. 2019 11 01; 160(11):2543-2555. Kim T, Li D, Terasaka T, Nicholas DA, Knight VS, Yang JJ, Lawson MA. PMID: 31504396; PMCID: PMC6779075.

View in: PubMed Mentions: 7 Fields:
End Endocrinology
Translation:Animals Cells
The RNA-Binding Protein ELAVL1 Regulates GnRH Receptor Expression and the Response to GnRH. Endocrinology. 2019 08 01; 160(8):1999-2014. Terasaka T, Kim T, Dave H, Gangapurkar B, Nicholas DA, Muñoz O, Terasaka E, Li D, Lawson MA. PMID: 31188427; PMCID: PMC6660905.

View in: PubMed Mentions: 10 Fields:
End Endocrinology
Translation:Animals Cells
Individual 17-Hydroxyprogesterone Responses to hCG Are Not Correlated With Follicle Size in Polycystic Ovary Syndrome. J Endocr Soc. 2019 Apr 01; 3(4):687-698. Homer MV, Toloubeydokhti T, Lawson MA, Garzo G, Duleba AJ, Chang RJ. PMID: 30918916; PMCID: PMC6411416.

View in: PubMed Mentions: 3
Induction of Stress Signaling In Vitro and Suppression of Gonadotropin Secretion by Free Fatty Acids in Female Mouse Gonadotropes. Endocrinology. 2018 02 01; 159(2):1074-1087. Li S, Mbong EF, John DT, Terasaka T, Li D, Lawson MA. PMID: 29315384; PMCID: PMC5793794.

View in: PubMed Mentions: 11 Fields:
End Endocrinology
Translation:Animals Cells
Reactive Oxygen Species Link Gonadotropin-Releasing Hormone Receptor Signaling Cascades in the Gonadotrope. Front Endocrinol (Lausanne). 2017; 8:286. Terasaka T, Adakama ME, Li S, Kim T, Terasaka E, Li D, Lawson MA. PMID: 29163358; PMCID: PMC5671645.

View in: PubMed Mentions: 6 Fields:
End Endocrinology
GnRH Regulates Gonadotropin Gene Expression Through NADPH/Dual Oxidase-Derived Reactive Oxygen Species. Endocrinology. 2015 Jun; 156(6):2185-99. Kim T, Lawson MA. PMID: 25849727; PMCID: PMC4430611.

View in: PubMed Mentions: 10 Fields:
End Endocrinology
Translation:Animals Cells
Lack of Serum anti-Mullerian hormone responses after recombinant human chorionic gonadotropin stimulation in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2015 Jan; 100(1):251-7. Cook-Andersen H, Chuan SS, Maas K, Rosencrantz MA, Su HI, Lawson M, Mason HD, Chang RJ. PMID: 25303490; PMCID: PMC4283023.

View in: PubMed Mentions: 6 Fields:
End Endocrinology Met Metabolism
Translation:Humans
Evaluation of post-contrast myocardial t1 in duchenne muscular dystrophy using cardiac magnetic resonance imaging. Pediatr Cardiol. 2015 Jan; 36(1):49-56. Soslow JH, Damon BM, Saville BR, Lu Z, Burnette WB, Lawson MA, Parra DA, Sawyer DB, Markham LW. PMID: 25070387; PMCID: PMC4439095.

View in: PubMed Mentions: 22 Fields:
Car Cardiology Ped Pediatrics
Translation:Humans
Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins. J Biol Chem. 2014 Jan 17; 289(3):1580-91. Chen B, Siderovski DP, Neubig RR, Lawson MA, Trejo J. PMID: 24297163; PMCID: PMC3894338.

View in: PubMed Mentions: 8 Fields:
Bio Biochemistry
Translation:Humans Cells
Polyribosome and ribonucleoprotein complex redistribution of mRNA induced by GnRH involves both EIF2AK3 and MAPK signaling. Mol Cell Endocrinol. 2014 Jan 25; 382(1):346-357. Do MT, Kim T, He F, Dave H, Intriago RE, Astorga UA, Jain S, Lawson MA. PMID: 24161835; PMCID: PMC4042833.

View in: PubMed Mentions: 10 Fields:
Cel Cell Biology End Endocrinology Mol Molecular Biology
Translation:Animals Cells
Translational control of gene expression in the gonadotrope. Mol Cell Endocrinol. 2014 Mar 25; 385(1-2):78-87. Kim T, Do MH, Lawson MA. PMID: 24035865; PMCID: PMC4009948.

View in: PubMed Mentions: 12 Fields:
Cel Cell Biology End Endocrinology Mol Molecular Biology
Translation:Humans Animals Cells
Mutual interaction of kisspeptin, estrogen and bone morphogenetic protein-4 activity in GnRH regulation by GT1-7 cells. Mol Cell Endocrinol. 2013 Dec 05; 381(1-2):8-15. Terasaka T, Otsuka F, Tsukamoto N, Nakamura E, Inagaki K, Toma K, Ogura-Ochi K, Glidewell-Kenney C, Lawson MA, Makino H. PMID: 23880664; PMCID: PMC4079587.

View in: PubMed Mentions: 12 Fields:
Cel Cell Biology End Endocrinology Mol Molecular Biology
Translation:Humans Animals Cells
Commentary: meeting the challenge to train the next generation of endocrinologists: filling, diversifying, and plugging leaks in the career pipeline. Endocrinology. 2013 Aug; 154(8):2581-5. Lawson MA. PMID: 23709087; PMCID: PMC3713218.

View in: PubMed Mentions: Fields:
End Endocrinology
Translation:Humans
hCG-induced endoplasmic reticulum stress triggers apoptosis and reduces steroidogenic enzyme expression through activating transcription factor 6 in Leydig cells of the testis. J Mol Endocrinol. 2013 Apr; 50(2):151-66. Park SJ, Kim TS, Park CK, Lee SH, Kim JM, Lee KS, Lee IK, Park JW, Lawson MA, Lee DS. PMID: 23256993; PMCID: PMC4111658.

View in: PubMed Mentions: 22 Fields:
End Endocrinology Mol Molecular Biology
Translation:Humans Animals Cells
Biventricular noncompaction cardiomyopathy in a patient presenting with new onset seizure: case report. Case Rep Cardiol. 2012; 2012:924865. Odiete O, Nagendra R, Lawson MA, Okafor H. PMID: 24826276; PMCID: PMC4008239.

View in: PubMed Mentions: 1
Right ventricular plasticity and functional imaging. Pulm Circ. 2012 Jul; 2(3):309-26. Brittain EL, Hemnes AR, Keebler M, Lawson M, Byrd BF, Disalvo T. PMID: 23130100; PMCID: PMC3487300.

View in: PubMed Mentions: 9
Interaction between gonadotropin-releasing hormone and bone morphogenetic protein-6 and -7 signaling in LβT2 gonadotrope cells. Mol Cell Endocrinol. 2012 Jan 02; 348(1):147-54. Takeda M, Otsuka F, Takahashi H, Inagaki K, Miyoshi T, Tsukamoto N, Makino H, Lawson MA. PMID: 21846488; PMCID: PMC3719407.

View in: PubMed Mentions: 6 Fields:
Cel Cell Biology End Endocrinology Mol Molecular Biology
Translation:Humans Animals Cells
Gonadotropin-releasing hormone pulse sensitivity of follicle-stimulating hormone-beta gene is mediated by differential expression of positive regulatory activator protein 1 factors and corepressors SKIL and TGIF1. Mol Endocrinol. 2011 Aug; 25(8):1387-403. Mistry DS, Tsutsumi R, Fernandez M, Sharma S, Cardenas SA, Lawson MA, Webster NJ. PMID: 21659477; PMCID: PMC3146254.

View in: PubMed Mentions: 23 Fields:
End Endocrinology Mol Molecular Biology
Translation:Animals Cells
Modulation of gonadotropin-releasing hormone-induced extracellular signal-regulated kinase activation by dual-specificity protein phosphatase 1 in LbetaT2 gonadotropes. Endocrinology. 2010 Oct; 151(10):4882-93. Nguyen KA, Intriago RE, Upadhyay HC, Santos SJ, Webster NJ, Lawson MA. PMID: 20685880; PMCID: PMC2946148.

View in: PubMed Mentions: 14 Fields:
End Endocrinology
Translation:Animals Cells
Serum anti-mullerian hormone concentrations are elevated in oligomenorrheic girls without evidence of hyperandrogenism. J Clin Endocrinol Metab. 2010 Apr; 95(4):1786-92. Park AS, Lawson MA, Chuan SS, Oberfield SE, Hoeger KM, Witchel SF, Chang RJ. PMID: 20150576; PMCID: PMC2853993.

View in: PubMed Mentions: 29 Fields:
End Endocrinology Met Metabolism
Translation:Humans
Regulation of GNRH production by estrogen and bone morphogenetic proteins in GT1-7 hypothalamic cells. J Endocrinol. 2009 Oct; 203(1):87-97. Otani H, Otsuka F, Takeda M, Mukai T, Terasaka T, Miyoshi T, Inagaki K, Suzuki J, Ogura T, Lawson MA, Makino H. PMID: 19635757; PMCID: PMC2768486.

View in: PubMed Mentions: 8 Fields:
End Endocrinology
Translation:Animals Cells
Insulin augments gonadotropin-releasing hormone induction of translation in LbetaT2 cells. Mol Cell Endocrinol. 2009 Nov 13; 311(1-2):47-54. Navratil AM, Song H, Hernandez JB, Cherrington BD, Santos SJ, Low JM, Do MH, Lawson MA. PMID: 19632296; PMCID: PMC2739255.

View in: PubMed Mentions: 17 Fields:
Cel Cell Biology End Endocrinology Mol Molecular Biology
Translation:Animals Cells
GNRH induces the unfolded protein response in the LbetaT2 pituitary gonadotrope cell line. Mol Endocrinol. 2009 Jan; 23(1):100-12. Do MH, Santos SJ, Lawson MA. PMID: 18974261; PMCID: PMC2646596.

View in: PubMed Mentions: 14 Fields:
End Endocrinology Mol Molecular Biology
Translation:Animals Cells
A proteomic comparison of immature and mature mouse gonadotrophs reveals novel differentially expressed nuclear proteins that regulate gonadotropin gene transcription and RNA splicing. Biol Reprod. 2008 Sep; 79(3):546-61. Feng J, Lawson MA, Melamed P. PMID: 18480465; PMCID: PMC2574604.

View in: PubMed Mentions: 12 Fields:
Rep Reproductive Medicine
Translation:Animals Cells
Evidence for insulin suppression of baseline luteinizing hormone in women with polycystic ovarian syndrome and normal women. J Clin Endocrinol Metab. 2008 Jun; 93(6):2089-96. Lawson MA, Jain S, Sun S, Patel K, Malcolm PJ, Chang RJ. PMID: 18334581; PMCID: PMC2435648.

View in: PubMed Mentions: 22 Fields:
End Endocrinology Met Metabolism
Translation:Humans
Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2. Mol Endocrinol. 2007 May; 21(5):1175-91. Lawson MA, Tsutsumi R, Zhang H, Talukdar I, Butler BK, Santos SJ, Mellon PL, Webster NJ. PMID: 17299135; PMCID: PMC2932486.

View in: PubMed Mentions: 58 Fields:
End Endocrinology Mol Molecular Biology
Translation:Animals Cells
Activin modulates the transcriptional response of LbetaT2 cells to gonadotropin-releasing hormone and alters cellular proliferation. Mol Endocrinol. 2006 Nov; 20(11):2909-30. Zhang H, Bailey JS, Coss D, Lin B, Tsutsumi R, Lawson MA, Mellon PL, Webster NJ. PMID: 16772531; PMCID: PMC2673912.

View in: PubMed Mentions: 28 Fields:
End Endocrinology Mol Molecular Biology
Translation:Animals Cells
Acute regulation of translation initiation by gonadotropin-releasing hormone in the gonadotrope cell line LbetaT2. Mol Endocrinol. 2004 May; 18(5):1301-12. Nguyen KA, Santos SJ, Kreidel MK, Diaz AL, Rey R, Lawson MA. PMID: 14752057; PMCID: PMC4547917.

View in: PubMed Mentions: 26 Fields:
End Endocrinology Mol Molecular Biology
Translation:Animals Cells
Increased luteinizing hormone secretion in women with polycystic ovary syndrome is unaltered by prolonged insulin infusion. J Clin Endocrinol Metab. 2003 Nov; 88(11):5456-61. Patel K, Coffler MS, Dahan MH, Yoo RY, Lawson MA, Malcom PJ, Chang RJ. PMID: 14602789.

View in: PubMed Mentions: 10 Fields:
End Endocrinology Met Metabolism
Translation:Humans CTClinical Trials
Different signaling pathways control acute induction versus long-term repression of LHbeta transcription by GnRH. Endocrinology. 2002 Sep; 143(9):3414-26. Vasilyev VV, Lawson MA, Dipaolo D, Webster NJ, Mellon PL. PMID: 12193554; PMCID: PMC2932485.

View in: PubMed Mentions: 14 Fields:
End Endocrinology
Translation:Animals Cells
Mechanism of selective retinoid X receptor agonist-induced hypothyroidism in the rat. Endocrinology. 2002 Aug; 143(8):2880-5. Liu S, Ogilvie KM, Klausing K, Lawson MA, Jolley D, Li D, Bilakovics J, Pascual B, Hein N, Urcan M, Leibowitz MD. PMID: 12130551.

View in: PubMed Mentions: 23 Fields:
End Endocrinology
Translation:Animals
Neuron-specific expression in vivo by defined transcription regulatory elements of the GnRH gene. Endocrinology. 2002 Apr; 143(4):1404-12. Lawson MA, Macconell LA, Kim J, Powl BT, Nelson SB, Mellon PL. PMID: 11897697.

View in: PubMed Mentions: 20 Fields:
End Endocrinology
Translation:Animals Cells
Activation of translation in pituitary gonadotrope cells by gonadotropin-releasing hormone. Mol Endocrinol. 2000 Nov; 14(11):1811-9. Sosnowski R, Mellon PL, Lawson MA. PMID: 11075814.

View in: PubMed Mentions: 13 Fields:
End Endocrinology Mol Molecular Biology
Translation:Animals Cells
Neuron-specific expression of the rat gonadotropin-releasing hormone gene is conferred by interactions of a defined promoter element with the enhancer in GT1-7 cells. Mol Endocrinol. 2000 Sep; 14(9):1509-22. Nelson SB, Lawson MA, Kelley CG, Mellon PL. PMID: 10976927.

View in: PubMed Mentions: 30 Fields:
End Endocrinology Mol Molecular Biology
Translation:Animals Cells
Activin A regulation of gonadotropin-releasing hormone synthesis and release in vitro. Neuroendocrinology. 1999 Oct; 70(4):246-54. MacConell LA, Lawson MA, Mellon PL, Roberts VJ. PMID: 10529619.

View in: PubMed Mentions: 5 Fields:
End Endocrinology Neu Neurology
Translation:Animals Cells
Expression of GATA-4 in migrating gonadotropin-releasing neurons of the developing mouse. Mol Cell Endocrinol. 1998 May 25; 140(1-2):157-61. Lawson MA, Mellon PL. PMID: 9722184.

View in: PubMed Mentions: 10 Fields:
Cel Cell Biology End Endocrinology Mol Molecular Biology
Translation:Animals Cells
Multiple factors interacting at the GATA sites of the gonadotropin-releasing hormone neuron-specific enhancer regulate gene expression. Mol Endocrinol. 1998 Mar; 12(3):364-77. Lawson MA, Buhain AR, Jovenal JC, Mellon PL. PMID: 9514154.

View in: PubMed Mentions: 15 Fields:
End Endocrinology Mol Molecular Biology
Translation:Humans Animals Cells
GATA factors are essential for activity of the neuron-specific enhancer of the gonadotropin-releasing hormone gene. Mol Cell Biol. 1996 Jul; 16(7):3596-605. Lawson MA, Whyte DB, Mellon PL. PMID: 8668176; PMCID: PMC231355.

View in: PubMed Mentions: 29 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
A neuron-specific enhancer targets expression of the gonadotropin-releasing hormone gene to hypothalamic neurosecretory neurons. Mol Endocrinol. 1995 Apr; 9(4):467-77. Whyte DB, Lawson MA, Belsham DD, Eraly SA, Bond CT, Adelman JP, Mellon PL. PMID: 7659090.

View in: PubMed Mentions: 32 Fields:
End Endocrinology Mol Molecular Biology
Translation:Animals Cells
Hypothalamus-specific regulation of gonadotropin-releasing hormone gene expression. Recent Prog Horm Res. 1995; 50:459-63. Lawson MA, Whyte DB, Eraly SA, Mellon PL. PMID: 7740182.

View in: PubMed Mentions: 3 Fields:
End Endocrinology
Translation:Humans Animals Cells