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    Mark Lawson

    TitleProfessor, In Residence
    SchoolUniversity of California, San Diego
    DepartmentReproductive Medicine
    Address9500 Gilman Drive #0674
    CA La Jolla 92093
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      Collapse Biography 
      Collapse Education and Training
      San Diego Sate UniversityB.S.1986Microbiology
      University of California, IrvinePh.D.1991Microbiology and Molecular Genetics
      Collapse Awards and Honors
      UC Irvine1986  - 1987University Fellowship in Biological Science
      UC Irvine1987  - 1991Trainee, National Canceer Institute
      UCSD1992  - 1993Ford Foundation/National Academy of Sciences Postdocotoral Fellowship
      UCSD1994  - 1996University of California President's Postdoctoral Fellowship
      UCSD2006Equal Opportunity/Affirmative Action and Diversity Award
      UCSD2014Equal Opportunity/Affirmative Action and Diversity Award

      Collapse Research 
      Collapse Research Activities and Funding
      Endocrine Network for Undergraduate Research and Carrier Development Opportunitie
      NIH/NIGMS T36GM095349Mar 1, 2011 - Feb 29, 2016
      Role: Principal Investigator
      Mentoring Young Minds to Increase Diversity in the Biomedical Research
      NIH/NIGMS R25GM083275Mar 1, 2008 - Jan 31, 2023
      Role: Co-Principal Investigator
      Insulin Signaling in the Anterior Pituitary
      NIH/NIDDK R21DK068167Mar 1, 2005 - Feb 28, 2008
      Role: Principal Investigator
      Mechanisms of Response to GnRH Receptor Signaling
      NIH/NICHD K02HD040803Sep 11, 2001 - Aug 31, 2006
      Role: Principal Investigator
      GnRH Signaling Mechanisms in the Pituitary Gonadotrope
      NIH/NICHD R01HD037568Mar 1, 2000 - Jun 30, 2015
      Role: Principal Investigator
      NIH/NIDDK R03DK052284Sep 30, 1996 - Aug 31, 1999
      Role: Principal Investigator
      Center for Reproductive Science and Medicine
      NIH/NICHD P50HD012303Dec 1, 1978 - Mar 31, 2021
      Role: Co-Investigator

      Collapse ORNG Applications 
      Collapse Featured Publications
      Collapse Websites
      Collapse Featured Videos
      Collapse In The News

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Kim T, Lawson M. GnRH Regulates Gonadotropin Gene Expression Through NADPH/Dual Oxidase-Derived Reactive Oxygen Species. Endocrinology. 2015 Jun; 156(6):2185-99. PMID: 25849727; PMCID: PMC4430611.
      2. Cook-Andersen H, Chuan SS, Maas K, Rosencrantz MA, Su HI, Lawson M, Mason HD, Chang RJ. Lack of Serum anti-Mullerian hormone responses after recombinant human chorionic gonadotropin stimulation in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2015 Jan; 100(1):251-7. PMID: 25303490; PMCID: PMC4283023.
      3. Chen B, Siderovski DP, Neubig RR, Lawson M, Trejo J. Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins. J Biol Chem. 2014 Jan 17; 289(3):1580-91. PMID: 24297163; PMCID: PMC3894338.
      4. Do MH, Kim T, He F, Dave H, Intriago RE, Astorga UA, Jain S, Lawson M. Polyribosome and ribonucleoprotein complex redistribution of mRNA induced by GnRH involves both EIF2AK3 and MAPK signaling. Mol Cell Endocrinol. 2014 Jan 25; 382(1):346-57. PMID: 24161835; PMCID: PMC4042833.
      5. Kim T, Do MH, Lawson M. Translational control of gene expression in the gonadotrope. Mol Cell Endocrinol. 2014 Mar 25; 385(1-2):78-87. PMID: 24035865; PMCID: PMC4009948.
      6. Terasaka T, Otsuka F, Tsukamoto N, Nakamura E, Inagaki K, Toma K, Ogura-Ochi K, Glidewell-Kenney C, Lawson M, Makino H. Mutual interaction of kisspeptin, estrogen and bone morphogenetic protein-4 activity in GnRH regulation by GT1-7 cells. Mol Cell Endocrinol. 2013 Dec 05; 381(1-2):8-15. PMID: 23880664; PMCID: PMC4079587.
      7. Lawson M. Commentary: meeting the challenge to train the next generation of endocrinologists: filling, diversifying, and plugging leaks in the career pipeline. Endocrinology. 2013 Aug; 154(8):2581-5. PMID: 23709087; PMCID: PMC3713218.
      8. Park SJ, Kim TS, Park CK, Lee SH, Kim JM, Lee KS, Lee IK, Park JW, Lawson M, Lee DS. hCG-induced endoplasmic reticulum stress triggers apoptosis and reduces steroidogenic enzyme expression through activating transcription factor 6 in Leydig cells of the testis. J Mol Endocrinol. 2013 Apr; 50(2):151-66. PMID: 23256993; PMCID: PMC4111658.
      9. Takeda M, Otsuka F, Takahashi H, Inagaki K, Miyoshi T, Tsukamoto N, Makino H, Lawson M. Interaction between gonadotropin-releasing hormone and bone morphogenetic protein-6 and -7 signaling in LßT2 gonadotrope cells. Mol Cell Endocrinol. 2012 Jan 02; 348(1):147-54. PMID: 21846488; PMCID: PMC3719407.
      10. Mistry DS, Tsutsumi R, Fernandez M, Sharma S, Cardenas SA, Lawson M, Webster NJ. Gonadotropin-releasing hormone pulse sensitivity of follicle-stimulating hormone-beta gene is mediated by differential expression of positive regulatory activator protein 1 factors and corepressors SKIL and TGIF1. Mol Endocrinol. 2011 Aug; 25(8):1387-403. PMID: 21659477; PMCID: PMC3146254.
      11. Nguyen KA, Intriago RE, Upadhyay HC, Santos SJ, Webster NJ, Lawson M. Modulation of gonadotropin-releasing hormone-induced extracellular signal-regulated kinase activation by dual-specificity protein phosphatase 1 in LbetaT2 gonadotropes. Endocrinology. 2010 Oct; 151(10):4882-93. PMID: 20685880; PMCID: PMC2946148.
      12. Park AS, Lawson M, Chuan SS, Oberfield SE, Hoeger KM, Witchel SF, Chang RJ. Serum anti-mullerian hormone concentrations are elevated in oligomenorrheic girls without evidence of hyperandrogenism. J Clin Endocrinol Metab. 2010 Apr; 95(4):1786-92. PMID: 20150576; PMCID: PMC2853993.
      13. Otani H, Otsuka F, Takeda M, Mukai T, Terasaka T, Miyoshi T, Inagaki K, Suzuki J, Ogura T, Lawson M, Makino H. Regulation of GNRH production by estrogen and bone morphogenetic proteins in GT1-7 hypothalamic cells. J Endocrinol. 2009 Oct; 203(1):87-97. PMID: 19635757; PMCID: PMC2768486.
      14. Navratil AM, Song H, Hernandez JB, Cherrington BD, Santos SJ, Low JM, Do MH, Lawson M. Insulin augments gonadotropin-releasing hormone induction of translation in LbetaT2 cells. Mol Cell Endocrinol. 2009 Nov 13; 311(1-2):47-54. PMID: 19632296; PMCID: PMC2739255.
      15. Do MH, Santos SJ, Lawson M. GNRH induces the unfolded protein response in the LbetaT2 pituitary gonadotrope cell line. Mol Endocrinol. 2009 Jan; 23(1):100-12. PMID: 18974261; PMCID: PMC2646596.
      16. Feng J, Lawson M, Melamed P. A proteomic comparison of immature and mature mouse gonadotrophs reveals novel differentially expressed nuclear proteins that regulate gonadotropin gene transcription and RNA splicing. Biol Reprod. 2008 Sep; 79(3):546-61. PMID: 18480465; PMCID: PMC2574604.
      17. Lawson M, Jain S, Sun S, Patel K, Malcolm PJ, Chang RJ. Evidence for insulin suppression of baseline luteinizing hormone in women with polycystic ovarian syndrome and normal women. J Clin Endocrinol Metab. 2008 Jun; 93(6):2089-96. PMID: 18334581; PMCID: PMC2435648.
      18. Lawson M, Tsutsumi R, Zhang H, Talukdar I, Butler BK, Santos SJ, Mellon PL, Webster NJ. Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2. Mol Endocrinol. 2007 May; 21(5):1175-91. PMID: 17299135; PMCID: PMC2932486.
      19. Zhang H, Bailey JS, Coss D, Lin B, Tsutsumi R, Lawson M, Mellon PL, Webster NJ. Activin modulates the transcriptional response of LbetaT2 cells to gonadotropin-releasing hormone and alters cellular proliferation. Mol Endocrinol. 2006 Nov; 20(11):2909-30. PMID: 16772531; PMCID: PMC2673912.
      20. Nguyen KA, Santos SJ, Kreidel MK, Diaz AL, Rey R, Lawson M. Acute regulation of translation initiation by gonadotropin-releasing hormone in the gonadotrope cell line LbetaT2. Mol Endocrinol. 2004 May; 18(5):1301-12. PMID: 14752057; PMCID: PMC4547917.
      21. Patel K, Coffler MS, Dahan MH, Yoo RY, Lawson M, Malcom PJ, Chang RJ. Increased luteinizing hormone secretion in women with polycystic ovary syndrome is unaltered by prolonged insulin infusion. J Clin Endocrinol Metab. 2003 Nov; 88(11):5456-61. PMID: 14602789.
        View in: PubMed
      22. Vasilyev VV, Lawson M, Dipaolo D, Webster NJ, Mellon PL. Different signaling pathways control acute induction versus long-term repression of LHbeta transcription by GnRH. Endocrinology. 2002 Sep; 143(9):3414-26. PMID: 12193554; PMCID: PMC2932485.
      23. Liu S, Ogilvie KM, Klausing K, Lawson M, Jolley D, Li D, Bilakovics J, Pascual B, Hein N, Urcan M, Leibowitz MD. Mechanism of selective retinoid X receptor agonist-induced hypothyroidism in the rat. Endocrinology. 2002 Aug; 143(8):2880-5. PMID: 12130551.
        View in: PubMed
      24. Lawson M, Macconell LA, Kim J, Powl BT, Nelson SB, Mellon PL. Neuron-specific expression in vivo by defined transcription regulatory elements of the GnRH gene. Endocrinology. 2002 Apr; 143(4):1404-12. PMID: 11897697.
        View in: PubMed
      25. Lawson M, Mellon PL. Expression of GATA-4 in migrating gonadotropin-releasing neurons of the developing mouse. Mol Cell Endocrinol. 1998 May 25; 140(1-2):157-61. PMID: 9722184.
        View in: PubMed
      26. Lawson M, Buhain AR, Jovenal JC, Mellon PL. Multiple factors interacting at the GATA sites of the gonadotropin-releasing hormone neuron-specific enhancer regulate gene expression. Mol Endocrinol. 1998 Mar; 12(3):364-77. PMID: 9514154.
        View in: PubMed