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Mark Lawson

TitleProfessor, In Residence
InstitutionUniversity of California San Diego
DepartmentReproductive Medicine
Address9500 Gilman Drive #0674
La Jolla CA 92093
Phone858-822-4128
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    Collapse Biography 
    Collapse Education and Training
    San Diego Sate UniversityB.S.1986Microbiology
    University of California, IrvinePh.D.1991Microbiology and Molecular Genetics
    Collapse Awards and Honors
    UC Irvine1986  - 1987University Fellowship in Biological Science
    UC Irvine1987  - 1991Trainee, National Canceer Institute
    UCSD1992  - 1993Ford Foundation/National Academy of Sciences Postdocotoral Fellowship
    UCSD1994  - 1996University of California President's Postdoctoral Fellowship
    UCSD2006Equal Opportunity/Affirmative Action and Diversity Award
    UCSD2014Equal Opportunity/Affirmative Action and Diversity Award

    Collapse Research 
    Collapse Research Activities and Funding
    Endocrine Network for Undergraduate Research and Carrier Development Opportunitie
    NIH/NIGMS T36GM095349Mar 1, 2011 - Feb 29, 2016
    Role: Principal Investigator
    Mentoring Young Minds to Increase Diversity in the Biomedical Research
    NIH/NIGMS R25GM083275Mar 1, 2008 - Jan 31, 2023
    Role: Co-Principal Investigator
    Insulin Signaling in the Anterior Pituitary
    NIH/NIDDK R21DK068167Mar 1, 2005 - Feb 28, 2008
    Role: Principal Investigator
    Mechanisms of Response to GnRH Receptor Signaling
    NIH/NICHD K02HD040803Sep 11, 2001 - Aug 31, 2006
    Role: Principal Investigator
    GnRH Signaling Mechanisms in the Pituitary Gonadotrope
    NIH/NICHD R01HD037568Mar 1, 2000 - Jun 30, 2015
    Role: Principal Investigator
    GATA FACTORS IN ENDOCRINE DEVELOPMENT
    NIH/NIDDK R03DK052284Sep 30, 1996 - Aug 31, 1999
    Role: Principal Investigator
    Center for Reproductive Science and Medicine
    NIH/NICHD P50HD012303Dec 1, 1978 - Mar 31, 2021
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Yang S, O'Leary J, Lawson M. A Young Man With Cardiomegaly and Edema. JAMA Cardiol. 2018 May 16. PMID: 29800038.
      View in: PubMed
    2. Bradham W, Ormseth MJ, Elumogo C, Palanisamy S, Liu CY, Lawson M, Soslow JH, Kawel-Boehm N, Bluemke DA, Stein CM. Absence of Fibrosis and Inflammation by Cardiac Magnetic Resonance Imaging in Rheumatoid Arthritis Patients with Low to Moderate Disease Activity. J Rheumatol. 2018 Apr 15. PMID: 29657146.
      View in: PubMed
    3. Li S, Mbong EF, John DT, Terasaka T, Li D, Lawson M. Induction of Stress Signaling In Vitro and Suppression of Gonadotropin Secretion by Free Fatty Acids in Female Mouse Gonadotropes. Endocrinology. 2018 02 01; 159(2):1074-1087. PMID: 29315384.
      View in: PubMed
    4. Terasaka T, Adakama ME, Li S, Kim T, Terasaka E, Li D, Lawson M. Reactive Oxygen Species Link Gonadotropin-Releasing Hormone Receptor Signaling Cascades in the Gonadotrope. Front Endocrinol (Lausanne). 2017; 8:286. PMID: 29163358.
      View in: PubMed
    5. Bradham WS, Bell SP, Adkisson DW, Smith HM, Harrell FE, Lawson M, Ooi H, Sawyer DB, Kronenberg MW. Myocardial T1 Measurement Predicts Beneficial LV Remodeling After Long-Term Heart Failure Therapy. J Card Fail. 2017 Mar; 23(3):262-265. PMID: 27940336.
      View in: PubMed
    6. Soslow JH, Damon SM, Crum K, Lawson M, Slaughter JC, Xu M, Arai AE, Sawyer DB, Parra DA, Damon BM, Markham LW. Increased myocardial native T1 and extracellular volume in patients with Duchenne muscular dystrophy. J Cardiovasc Magn Reson. 2016 Jan 21; 18:5. PMID: 26795569; PMCID: PMC4722665.
    7. Montgomery JA, Abdallah W, Yoneda ZT, Brittain E, Aznaurov SG, Parvez B, Adkins K, Whalen SP, Estrada JC, Shen S, Crossley GH, Kanagasundram A, Saavedra P, Ellis CR, Lawson M, Darbar D, Shoemaker MB. Measurement of diffuse ventricular fibrosis with myocardial T1 in patients with atrial fibrillation. J Arrhythm. 2016 Feb; 32(1):51-6. PMID: 26949431; PMCID: PMC4759117.
    8. Kim T, Lawson M. GnRH Regulates Gonadotropin Gene Expression Through NADPH/Dual Oxidase-Derived Reactive Oxygen Species. Endocrinology. 2015 Jun; 156(6):2185-99. PMID: 25849727; PMCID: PMC4430611.
    9. Cook-Andersen H, Chuan SS, Maas K, Rosencrantz MA, Su HI, Lawson M, Mason HD, Chang RJ. Lack of Serum anti-Mullerian hormone responses after recombinant human chorionic gonadotropin stimulation in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2015 Jan; 100(1):251-7. PMID: 25303490; PMCID: PMC4283023.
    10. Lawson M, Bell SP, Adkisson DW, Wang L, Ooi H, Sawyer DB, Kronenberg MW. High reproducibility of adenosine stress cardiac MR myocardial perfusion imaging in patients with non-ischaemic dilated cardiomyopathy. BMJ Open. 2014 Dec 16; 4(12):e005984. PMID: 25515841; PMCID: PMC4275661.
    11. Bell SP, Adkisson DW, Lawson M, Wang L, Ooi H, Sawyer DB, Kronenberg MW. Antifailure therapy including spironolactone improves left ventricular energy supply-demand relations in nonischemic dilated cardiomyopathy. J Am Heart Assoc. 2014 Aug 27; 3(4). PMID: 25164945; PMCID: PMC4310370.
    12. Soslow JH, Damon BM, Saville BR, Lu Z, Burnette WB, Lawson M, Parra DA, Sawyer DB, Markham LW. Evaluation of post-contrast myocardial t1 in duchenne muscular dystrophy using cardiac magnetic resonance imaging. Pediatr Cardiol. 2015 Jan; 36(1):49-56. PMID: 25070387; PMCID: PMC4439095.
    13. Chen B, Siderovski DP, Neubig RR, Lawson M, Trejo J. Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins. J Biol Chem. 2014 Jan 17; 289(3):1580-91. PMID: 24297163; PMCID: PMC3894338.
    14. Bell SP, Adkisson DW, Ooi H, Sawyer DB, Lawson M, Kronenberg MW. Impairment of subendocardial perfusion reserve and oxidative metabolism in nonischemic dilated cardiomyopathy. J Card Fail. 2013 Dec; 19(12):802-10. PMID: 24331202; PMCID: PMC3945036.
    15. Do MT, Kim T, He F, Dave H, Intriago RE, Astorga UA, Jain S, Lawson M. Polyribosome and ribonucleoprotein complex redistribution of mRNA induced by GnRH involves both EIF2AK3 and MAPK signaling. Mol Cell Endocrinol. 2014 Jan 25; 382(1):346-357. PMID: 24161835.
      View in: PubMed
    16. Kim T, Do MH, Lawson M. Translational control of gene expression in the gonadotrope. Mol Cell Endocrinol. 2014 Mar 25; 385(1-2):78-87. PMID: 24035865; PMCID: PMC4009948.
    17. Terasaka T, Otsuka F, Tsukamoto N, Nakamura E, Inagaki K, Toma K, Ogura-Ochi K, Glidewell-Kenney C, Lawson M, Makino H. Mutual interaction of kisspeptin, estrogen and bone morphogenetic protein-4 activity in GnRH regulation by GT1-7 cells. Mol Cell Endocrinol. 2013 Dec 05; 381(1-2):8-15. PMID: 23880664; PMCID: PMC4079587.
    18. Lawson M. Commentary: meeting the challenge to train the next generation of endocrinologists: filling, diversifying, and plugging leaks in the career pipeline. Endocrinology. 2013 Aug; 154(8):2581-5. PMID: 23709087; PMCID: PMC3713218.
    19. Park SJ, Kim TS, Park CK, Lee SH, Kim JM, Lee KS, Lee IK, Park JW, Lawson M, Lee DS. hCG-induced endoplasmic reticulum stress triggers apoptosis and reduces steroidogenic enzyme expression through activating transcription factor 6 in Leydig cells of the testis. J Mol Endocrinol. 2013 Apr; 50(2):151-66. PMID: 23256993; PMCID: PMC4111658.
    20. Odiete O, Nagendra R, Lawson M, Okafor H. Biventricular noncompaction cardiomyopathy in a patient presenting with new onset seizure: case report. Case Rep Cardiol. 2012; 2012:924865. PMID: 24826276; PMCID: PMC4008239.
    21. Brittain EL, Hemnes AR, Keebler M, Lawson M, Byrd BF, Disalvo T. Right ventricular plasticity and functional imaging. Pulm Circ. 2012 Jul; 2(3):309-26. PMID: 23130100; PMCID: PMC3487300.
    22. Takeda M, Otsuka F, Takahashi H, Inagaki K, Miyoshi T, Tsukamoto N, Makino H, Lawson M. Interaction between gonadotropin-releasing hormone and bone morphogenetic protein-6 and -7 signaling in LßT2 gonadotrope cells. Mol Cell Endocrinol. 2012 Jan 02; 348(1):147-54. PMID: 21846488; PMCID: PMC3719407.
    23. Mistry DS, Tsutsumi R, Fernandez M, Sharma S, Cardenas SA, Lawson M, Webster NJ. Gonadotropin-releasing hormone pulse sensitivity of follicle-stimulating hormone-beta gene is mediated by differential expression of positive regulatory activator protein 1 factors and corepressors SKIL and TGIF1. Mol Endocrinol. 2011 Aug; 25(8):1387-403. PMID: 21659477; PMCID: PMC3146254.
    24. Petersen JW, Forder JR, Thomas JD, Moyé LA, Lawson M, Loghin C, Traverse JH, Baraniuk S, Silva G, Pepine CJ. Quantification of myocardial segmental function in acute and chronic ischemic heart disease and implications for cardiovascular cell therapy trials: a review from the NHLBI-Cardiovascular Cell Therapy Research Network. JACC Cardiovasc Imaging. 2011 Jun; 4(6):671-9. PMID: 21679903; PMCID: PMC3157843.
    25. Nguyen KA, Intriago RE, Upadhyay HC, Santos SJ, Webster NJ, Lawson M. Modulation of gonadotropin-releasing hormone-induced extracellular signal-regulated kinase activation by dual-specificity protein phosphatase 1 in LbetaT2 gonadotropes. Endocrinology. 2010 Oct; 151(10):4882-93. PMID: 20685880; PMCID: PMC2946148.
    26. Park AS, Lawson M, Chuan SS, Oberfield SE, Hoeger KM, Witchel SF, Chang RJ. Serum anti-mullerian hormone concentrations are elevated in oligomenorrheic girls without evidence of hyperandrogenism. J Clin Endocrinol Metab. 2010 Apr; 95(4):1786-92. PMID: 20150576; PMCID: PMC2853993.
    27. Otani H, Otsuka F, Takeda M, Mukai T, Terasaka T, Miyoshi T, Inagaki K, Suzuki J, Ogura T, Lawson M, Makino H. Regulation of GNRH production by estrogen and bone morphogenetic proteins in GT1-7 hypothalamic cells. J Endocrinol. 2009 Oct; 203(1):87-97. PMID: 19635757; PMCID: PMC2768486.
    28. Navratil AM, Song H, Hernandez JB, Cherrington BD, Santos SJ, Low JM, Do MH, Lawson M. Insulin augments gonadotropin-releasing hormone induction of translation in LbetaT2 cells. Mol Cell Endocrinol. 2009 Nov 13; 311(1-2):47-54. PMID: 19632296; PMCID: PMC2739255.
    29. Ahmad RM, Umakanthan R, Lawson M, Leacche M, Solenkova NV, Byrne JG. Nonsurgical management of traumatic cardiac pseudoaneurysms. J Thorac Cardiovasc Surg. 2010 Apr; 139(4):e83-5. PMID: 19660408.
      View in: PubMed
    30. Hundley WG, Bluemke D, Bogaert JG, Friedrich MG, Higgins CB, Lawson M, McConnell MV, Raman SV, van Rossum AC, Flamm S, Kramer CM, Nagel E, Neubauer S. Society for Cardiovascular Magnetic Resonance guidelines for reporting cardiovascular magnetic resonance examinations. J Cardiovasc Magn Reson. 2009 Mar 03; 11:5. PMID: 19257889.
      View in: PubMed
    31. Do MH, Santos SJ, Lawson M. GNRH induces the unfolded protein response in the LbetaT2 pituitary gonadotrope cell line. Mol Endocrinol. 2009 Jan; 23(1):100-12. PMID: 18974261; PMCID: PMC2646596.
    32. Feng J, Lawson M, Melamed P. A proteomic comparison of immature and mature mouse gonadotrophs reveals novel differentially expressed nuclear proteins that regulate gonadotropin gene transcription and RNA splicing. Biol Reprod. 2008 Sep; 79(3):546-61. PMID: 18480465; PMCID: PMC2574604.
    33. Lawson M, Jain S, Sun S, Patel K, Malcolm PJ, Chang RJ. Evidence for insulin suppression of baseline luteinizing hormone in women with polycystic ovarian syndrome and normal women. J Clin Endocrinol Metab. 2008 Jun; 93(6):2089-96. PMID: 18334581; PMCID: PMC2435648.
    34. Lawson M, Tsutsumi R, Zhang H, Talukdar I, Butler BK, Santos SJ, Mellon PL, Webster NJ. Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2. Mol Endocrinol. 2007 May; 21(5):1175-91. PMID: 17299135; PMCID: PMC2932486.
    35. Zhang H, Bailey JS, Coss D, Lin B, Tsutsumi R, Lawson M, Mellon PL, Webster NJ. Activin modulates the transcriptional response of LbetaT2 cells to gonadotropin-releasing hormone and alters cellular proliferation. Mol Endocrinol. 2006 Nov; 20(11):2909-30. PMID: 16772531; PMCID: PMC2673912.
    36. Nguyen KA, Santos SJ, Kreidel MK, Diaz AL, Rey R, Lawson M. Acute regulation of translation initiation by gonadotropin-releasing hormone in the gonadotrope cell line LbetaT2. Mol Endocrinol. 2004 May; 18(5):1301-12. PMID: 14752057; PMCID: PMC4547917.
    37. Patel K, Coffler MS, Dahan MH, Yoo RY, Lawson M, Malcom PJ, Chang RJ. Increased luteinizing hormone secretion in women with polycystic ovary syndrome is unaltered by prolonged insulin infusion. J Clin Endocrinol Metab. 2003 Nov; 88(11):5456-61. PMID: 14602789.
      View in: PubMed
    38. Vasilyev VV, Lawson M, Dipaolo D, Webster NJ, Mellon PL. Different signaling pathways control acute induction versus long-term repression of LHbeta transcription by GnRH. Endocrinology. 2002 Sep; 143(9):3414-26. PMID: 12193554; PMCID: PMC2932485.
    39. Liu S, Ogilvie KM, Klausing K, Lawson M, Jolley D, Li D, Bilakovics J, Pascual B, Hein N, Urcan M, Leibowitz MD. Mechanism of selective retinoid X receptor agonist-induced hypothyroidism in the rat. Endocrinology. 2002 Aug; 143(8):2880-5. PMID: 12130551.
      View in: PubMed
    40. Lawson M, Macconell LA, Kim J, Powl BT, Nelson SB, Mellon PL. Neuron-specific expression in vivo by defined transcription regulatory elements of the GnRH gene. Endocrinology. 2002 Apr; 143(4):1404-12. PMID: 11897697.
      View in: PubMed
    41. Lawson M, Mellon PL. Expression of GATA-4 in migrating gonadotropin-releasing neurons of the developing mouse. Mol Cell Endocrinol. 1998 May 25; 140(1-2):157-61. PMID: 9722184.
      View in: PubMed
    42. Lawson M, Buhain AR, Jovenal JC, Mellon PL. Multiple factors interacting at the GATA sites of the gonadotropin-releasing hormone neuron-specific enhancer regulate gene expression. Mol Endocrinol. 1998 Mar; 12(3):364-77. PMID: 9514154.
      View in: PubMed