Mark Lawson

Title(s)Professor In Residence, Ob/Gyn & Reproductive sciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    San Diego Sate UniversityB.S.1986Microbiology
    University of California, IrvinePh.D.1991Microbiology and Molecular Genetics
    Collapse Awards and Honors
    UC Irvine1986  - 1987University Fellowship in Biological Science
    UC Irvine1987  - 1991Trainee, National Canceer Institute
    UCSD1992  - 1993Ford Foundation/National Academy of Sciences Postdocotoral Fellowship
    UCSD1994  - 1996University of California President's Postdoctoral Fellowship
    UCSD2006Equal Opportunity/Affirmative Action and Diversity Award
    UCSD2014Equal Opportunity/Affirmative Action and Diversity Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Endocrine Network for Undergraduate Research and Carrier Development Opportunitie
    NIH T36GM095349Mar 1, 2011 - Feb 28, 2017
    Role: Principal Investigator
    Mentoring Young Minds to Increase Diversity in the Biomedical Research
    NIH R25GM083275Mar 1, 2008 - Jan 31, 2023
    Role: Co-Principal Investigator
    Insulin Signaling in the Anterior Pituitary
    NIH R21DK068167Mar 1, 2005 - Feb 28, 2008
    Role: Principal Investigator
    Mechanisms of Response to GnRH Receptor Signaling
    NIH K02HD040803Sep 11, 2001 - Aug 31, 2006
    Role: Principal Investigator
    GnRH Signaling Mechanisms in the Pituitary Gonadotrope
    NIH R01HD037568Mar 1, 2000 - Jun 30, 2015
    Role: Principal Investigator
    NIH R03DK052284Sep 30, 1996 - Aug 31, 1999
    Role: Principal Investigator
    Center for Reproductive Science and Medicine
    NIH P50HD012303Dec 1, 1978 - Mar 31, 2021
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Featured Content 
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lipopolysaccharide-induced chronic inflammation increases female serum gonadotropins and shifts the pituitary transcriptomic landscape. Front Endocrinol (Lausanne). 2023; 14:1279878. Garcia C, Velez LM, Ujagar N, Del Mundo Z, Nguyen T, Fox C, Mark A, Fisch KM, Lawson MA, Duleba AJ, Seldin MM, Nicholas DA. PMID: 38260148; PMCID: PMC10801245.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. The Culture and Justice Quorum at University of California, San Diego: A Departmental Approach to Dismantling Structural Racism. Acad Med. 2023 08 01; 98(8):906-911. Ha D, Ghebrendrias S, Meadows A, LaCoursiere DY, Lewis A, Lawson M, Morales M, Gyamfi-Bannerman C, Brubaker L. PMID: 36862643.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis. Proc Natl Acad Sci U S A. 2021 12 07; 118(49). Molinar-Inglis O, Birch CA, Nicholas D, Orduña-Castillo L, Cisneros-Aguirre M, Patwardhan A, Chen B, Grimsey NJ, Coronel LJ, Lin H, Gomez Menzies PK, Lawson MA, Patel HH, Trejo J. PMID: 34873055; PMCID: PMC8670512.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    4. Androgen Suppresses In Vivo and In Vitro LH Pulse Secretion and Neural Kiss1 and Tac2 Gene Expression in Female Mice. Endocrinology. 2020 12 01; 161(12). Esparza LA, Terasaka T, Lawson MA, Kauffman AS. PMID: 33075809; PMCID: PMC7671291.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    5. GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes. Sci Rep. 2020 08 03; 10(1):13063. Nicholas DA, Knight VS, Tonsfeldt KJ, Terasaka T, Molinar-Inglis O, Stephens SBZ, Trejo J, Kauffman AS, Mellon PL, Lawson MA. PMID: 32747664; PMCID: PMC7400764.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    6. SRXN1 Is Necessary for Resolution of GnRH-Induced Oxidative Stress and Induction of Gonadotropin Gene Expression. Endocrinology. 2019 11 01; 160(11):2543-2555. Kim T, Li D, Terasaka T, Nicholas DA, Knight VS, Yang JJ, Lawson MA. PMID: 31504396; PMCID: PMC6779075.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    7. The RNA-Binding Protein ELAVL1 Regulates GnRH Receptor Expression and the Response to GnRH. Endocrinology. 2019 08 01; 160(8):1999-2014. Terasaka T, Kim T, Dave H, Gangapurkar B, Nicholas DA, Muñoz O, Terasaka E, Li D, Lawson MA. PMID: 31188427; PMCID: PMC6660905.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    8. Individual 17-Hydroxyprogesterone Responses to hCG Are Not Correlated With Follicle Size in Polycystic Ovary Syndrome. J Endocr Soc. 2019 Apr 01; 3(4):687-698. Homer MV, Toloubeydokhti T, Lawson MA, Garzo G, Duleba AJ, Chang RJ. PMID: 30918916; PMCID: PMC6411416.
      View in: PubMed   Mentions: 3  
    9. Induction of Stress Signaling In Vitro and Suppression of Gonadotropin Secretion by Free Fatty Acids in Female Mouse Gonadotropes. Endocrinology. 2018 02 01; 159(2):1074-1087. Li S, Mbong EF, John DT, Terasaka T, Li D, Lawson MA. PMID: 29315384; PMCID: PMC5793794.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    10. Reactive Oxygen Species Link Gonadotropin-Releasing Hormone Receptor Signaling Cascades in the Gonadotrope. Front Endocrinol (Lausanne). 2017; 8:286. Terasaka T, Adakama ME, Li S, Kim T, Terasaka E, Li D, Lawson MA. PMID: 29163358; PMCID: PMC5671645.
      View in: PubMed   Mentions: 6     Fields:    
    11. GnRH Regulates Gonadotropin Gene Expression Through NADPH/Dual Oxidase-Derived Reactive Oxygen Species. Endocrinology. 2015 Jun; 156(6):2185-99. Kim T, Lawson MA. PMID: 25849727; PMCID: PMC4430611.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    12. Lack of Serum anti-Mullerian hormone responses after recombinant human chorionic gonadotropin stimulation in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2015 Jan; 100(1):251-7. Cook-Andersen H, Chuan SS, Maas K, Rosencrantz MA, Su HI, Lawson M, Mason HD, Chang RJ. PMID: 25303490; PMCID: PMC4283023.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    13. Evaluation of post-contrast myocardial t1 in duchenne muscular dystrophy using cardiac magnetic resonance imaging. Pediatr Cardiol. 2015 Jan; 36(1):49-56. Soslow JH, Damon BM, Saville BR, Lu Z, Burnette WB, Lawson MA, Parra DA, Sawyer DB, Markham LW. PMID: 25070387; PMCID: PMC4439095.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    14. Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins. J Biol Chem. 2014 Jan 17; 289(3):1580-91. Chen B, Siderovski DP, Neubig RR, Lawson MA, Trejo J. PMID: 24297163; PMCID: PMC3894338.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    15. Polyribosome and ribonucleoprotein complex redistribution of mRNA induced by GnRH involves both EIF2AK3 and MAPK signaling. Mol Cell Endocrinol. 2014 Jan 25; 382(1):346-357. Do MT, Kim T, He F, Dave H, Intriago RE, Astorga UA, Jain S, Lawson MA. PMID: 24161835; PMCID: PMC4042833.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    16. Translational control of gene expression in the gonadotrope. Mol Cell Endocrinol. 2014 Mar 25; 385(1-2):78-87. Kim T, Do MH, Lawson MA. PMID: 24035865; PMCID: PMC4009948.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    17. Mutual interaction of kisspeptin, estrogen and bone morphogenetic protein-4 activity in GnRH regulation by GT1-7 cells. Mol Cell Endocrinol. 2013 Dec 05; 381(1-2):8-15. Terasaka T, Otsuka F, Tsukamoto N, Nakamura E, Inagaki K, Toma K, Ogura-Ochi K, Glidewell-Kenney C, Lawson MA, Makino H. PMID: 23880664; PMCID: PMC4079587.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    18. Commentary: meeting the challenge to train the next generation of endocrinologists: filling, diversifying, and plugging leaks in the career pipeline. Endocrinology. 2013 Aug; 154(8):2581-5. Lawson MA. PMID: 23709087; PMCID: PMC3713218.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. hCG-induced endoplasmic reticulum stress triggers apoptosis and reduces steroidogenic enzyme expression through activating transcription factor 6 in Leydig cells of the testis. J Mol Endocrinol. 2013 Apr; 50(2):151-66. Park SJ, Kim TS, Park CK, Lee SH, Kim JM, Lee KS, Lee IK, Park JW, Lawson MA, Lee DS. PMID: 23256993; PMCID: PMC4111658.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    20. Biventricular noncompaction cardiomyopathy in a patient presenting with new onset seizure: case report. Case Rep Cardiol. 2012; 2012:924865. Odiete O, Nagendra R, Lawson MA, Okafor H. PMID: 24826276; PMCID: PMC4008239.
      View in: PubMed   Mentions: 1  
    21. Right ventricular plasticity and functional imaging. Pulm Circ. 2012 Jul; 2(3):309-26. Brittain EL, Hemnes AR, Keebler M, Lawson M, Byrd BF, Disalvo T. PMID: 23130100; PMCID: PMC3487300.
      View in: PubMed   Mentions: 9  
    22. Interaction between gonadotropin-releasing hormone and bone morphogenetic protein-6 and -7 signaling in LβT2 gonadotrope cells. Mol Cell Endocrinol. 2012 Jan 02; 348(1):147-54. Takeda M, Otsuka F, Takahashi H, Inagaki K, Miyoshi T, Tsukamoto N, Makino H, Lawson MA. PMID: 21846488; PMCID: PMC3719407.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    23. Gonadotropin-releasing hormone pulse sensitivity of follicle-stimulating hormone-beta gene is mediated by differential expression of positive regulatory activator protein 1 factors and corepressors SKIL and TGIF1. Mol Endocrinol. 2011 Aug; 25(8):1387-403. Mistry DS, Tsutsumi R, Fernandez M, Sharma S, Cardenas SA, Lawson MA, Webster NJ. PMID: 21659477; PMCID: PMC3146254.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    24. Modulation of gonadotropin-releasing hormone-induced extracellular signal-regulated kinase activation by dual-specificity protein phosphatase 1 in LbetaT2 gonadotropes. Endocrinology. 2010 Oct; 151(10):4882-93. Nguyen KA, Intriago RE, Upadhyay HC, Santos SJ, Webster NJ, Lawson MA. PMID: 20685880; PMCID: PMC2946148.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    25. Serum anti-mullerian hormone concentrations are elevated in oligomenorrheic girls without evidence of hyperandrogenism. J Clin Endocrinol Metab. 2010 Apr; 95(4):1786-92. Park AS, Lawson MA, Chuan SS, Oberfield SE, Hoeger KM, Witchel SF, Chang RJ. PMID: 20150576; PMCID: PMC2853993.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    26. Regulation of GNRH production by estrogen and bone morphogenetic proteins in GT1-7 hypothalamic cells. J Endocrinol. 2009 Oct; 203(1):87-97. Otani H, Otsuka F, Takeda M, Mukai T, Terasaka T, Miyoshi T, Inagaki K, Suzuki J, Ogura T, Lawson MA, Makino H. PMID: 19635757; PMCID: PMC2768486.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    27. Insulin augments gonadotropin-releasing hormone induction of translation in LbetaT2 cells. Mol Cell Endocrinol. 2009 Nov 13; 311(1-2):47-54. Navratil AM, Song H, Hernandez JB, Cherrington BD, Santos SJ, Low JM, Do MH, Lawson MA. PMID: 19632296; PMCID: PMC2739255.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    28. GNRH induces the unfolded protein response in the LbetaT2 pituitary gonadotrope cell line. Mol Endocrinol. 2009 Jan; 23(1):100-12. Do MH, Santos SJ, Lawson MA. PMID: 18974261; PMCID: PMC2646596.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    29. A proteomic comparison of immature and mature mouse gonadotrophs reveals novel differentially expressed nuclear proteins that regulate gonadotropin gene transcription and RNA splicing. Biol Reprod. 2008 Sep; 79(3):546-61. Feng J, Lawson MA, Melamed P. PMID: 18480465; PMCID: PMC2574604.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    30. Evidence for insulin suppression of baseline luteinizing hormone in women with polycystic ovarian syndrome and normal women. J Clin Endocrinol Metab. 2008 Jun; 93(6):2089-96. Lawson MA, Jain S, Sun S, Patel K, Malcolm PJ, Chang RJ. PMID: 18334581; PMCID: PMC2435648.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    31. Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2. Mol Endocrinol. 2007 May; 21(5):1175-91. Lawson MA, Tsutsumi R, Zhang H, Talukdar I, Butler BK, Santos SJ, Mellon PL, Webster NJ. PMID: 17299135; PMCID: PMC2932486.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    32. Activin modulates the transcriptional response of LbetaT2 cells to gonadotropin-releasing hormone and alters cellular proliferation. Mol Endocrinol. 2006 Nov; 20(11):2909-30. Zhang H, Bailey JS, Coss D, Lin B, Tsutsumi R, Lawson MA, Mellon PL, Webster NJ. PMID: 16772531; PMCID: PMC2673912.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    33. Acute regulation of translation initiation by gonadotropin-releasing hormone in the gonadotrope cell line LbetaT2. Mol Endocrinol. 2004 May; 18(5):1301-12. Nguyen KA, Santos SJ, Kreidel MK, Diaz AL, Rey R, Lawson MA. PMID: 14752057; PMCID: PMC4547917.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    34. Increased luteinizing hormone secretion in women with polycystic ovary syndrome is unaltered by prolonged insulin infusion. J Clin Endocrinol Metab. 2003 Nov; 88(11):5456-61. Patel K, Coffler MS, Dahan MH, Yoo RY, Lawson MA, Malcom PJ, Chang RJ. PMID: 14602789.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCTClinical Trials
    35. Different signaling pathways control acute induction versus long-term repression of LHbeta transcription by GnRH. Endocrinology. 2002 Sep; 143(9):3414-26. Vasilyev VV, Lawson MA, Dipaolo D, Webster NJ, Mellon PL. PMID: 12193554; PMCID: PMC2932485.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    36. Mechanism of selective retinoid X receptor agonist-induced hypothyroidism in the rat. Endocrinology. 2002 Aug; 143(8):2880-5. Liu S, Ogilvie KM, Klausing K, Lawson MA, Jolley D, Li D, Bilakovics J, Pascual B, Hein N, Urcan M, Leibowitz MD. PMID: 12130551.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    37. Neuron-specific expression in vivo by defined transcription regulatory elements of the GnRH gene. Endocrinology. 2002 Apr; 143(4):1404-12. Lawson MA, Macconell LA, Kim J, Powl BT, Nelson SB, Mellon PL. PMID: 11897697.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    38. Activation of translation in pituitary gonadotrope cells by gonadotropin-releasing hormone. Mol Endocrinol. 2000 Nov; 14(11):1811-9. Sosnowski R, Mellon PL, Lawson MA. PMID: 11075814.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    39. Neuron-specific expression of the rat gonadotropin-releasing hormone gene is conferred by interactions of a defined promoter element with the enhancer in GT1-7 cells. Mol Endocrinol. 2000 Sep; 14(9):1509-22. Nelson SB, Lawson MA, Kelley CG, Mellon PL. PMID: 10976927.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    40. Activin A regulation of gonadotropin-releasing hormone synthesis and release in vitro. Neuroendocrinology. 1999 Oct; 70(4):246-54. MacConell LA, Lawson MA, Mellon PL, Roberts VJ. PMID: 10529619.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    41. Expression of GATA-4 in migrating gonadotropin-releasing neurons of the developing mouse. Mol Cell Endocrinol. 1998 May 25; 140(1-2):157-61. Lawson MA, Mellon PL. PMID: 9722184.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    42. Multiple factors interacting at the GATA sites of the gonadotropin-releasing hormone neuron-specific enhancer regulate gene expression. Mol Endocrinol. 1998 Mar; 12(3):364-77. Lawson MA, Buhain AR, Jovenal JC, Mellon PL. PMID: 9514154.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    43. GATA factors are essential for activity of the neuron-specific enhancer of the gonadotropin-releasing hormone gene. Mol Cell Biol. 1996 Jul; 16(7):3596-605. Lawson MA, Whyte DB, Mellon PL. PMID: 8668176; PMCID: PMC231355.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    44. A neuron-specific enhancer targets expression of the gonadotropin-releasing hormone gene to hypothalamic neurosecretory neurons. Mol Endocrinol. 1995 Apr; 9(4):467-77. Whyte DB, Lawson MA, Belsham DD, Eraly SA, Bond CT, Adelman JP, Mellon PL. PMID: 7659090.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    45. Hypothalamus-specific regulation of gonadotropin-releasing hormone gene expression. Recent Prog Horm Res. 1995; 50:459-63. Lawson MA, Whyte DB, Eraly SA, Mellon PL. PMID: 7740182.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
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