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Lori Broderick

Title(s)Assistant Adjunct Professor, Pediatrics
SchoolHealth Sciences
Phone858-534-1703
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    Collapse Research 
    Collapse Research Activities and Funding
    Molecular Genetics and Immunoregulatory mechanisms of PFAPA syndrome
    NIH/NICHD K08HD075830May 1, 2014 - Apr 30, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Broderick L, Yost S, Li D, McGeough MD, Booshehri LM, Guaderrama M, Brydges SD, Kucharova K, Patel NC, Harr M, Hakonarson H, Zackai E, Cowell IG, Austin CA, Hügle B, Gebauer C, Zhang J, Xu X, Wang J, Croker BA, Frazer KA, Putnam CD, Hoffman HM. Mutations in topoisomerase IIß result in a B cell immunodeficiency. Nat Commun. 2019 Aug 13; 10(1):3644. PMID: 31409799.
      View in: PubMed
    2. Hoss F, Mueller JL, Rojas Ringeling F, Rodriguez-Alcazar JF, Brinkschulte R, Seifert G, Stahl R, Broderick L, Putnam CD, Kolodner RD, Canzar S, Geyer M, Hoffman HM, Latz E. Alternative splicing regulates stochastic NLRP3 activity. Nat Commun. 2019 Jul 19; 10(1):3238. PMID: 31324763.
      View in: PubMed
    3. Broderick L. Hereditary Autoinflammatory Disorders: Recognition and Treatment. Immunol Allergy Clin North Am. 2019 02; 39(1):13-29. PMID: 30466770.
      View in: PubMed
    4. Hoffman HM, Broderick L. JAK inhibitors in autoinflammation. J Clin Invest. 2018 07 02; 128(7):2760-2762. PMID: 29889100.
      View in: PubMed
    5. McGeough MD, Wree A, Inzaugarat ME, Haimovich A, Johnson CD, Peña CA, Goldbach-Mansky R, Broderick L, Feldstein AE, Hoffman HM. TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies. J Clin Invest. 2017 12 01; 127(12):4488-4497. PMID: 29130929.
      View in: PubMed
    6. Nakanishi H, Kawashima Y, Kurima K, Chae JJ, Ross AM, Pinto-Patarroyo G, Patel SK, Muskett JA, Ratay JS, Chattaraj P, Park YH, Grevich S, Brewer CC, Hoa M, Kim HJ, Butman JA, Broderick L, Hoffman HM, Aksentijevich I, Kastner DL, Goldbach-Mansky R, Griffith AJ. NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy. Proc Natl Acad Sci U S A. 2017 09 12; 114(37):E7766-E7775. PMID: 28847925.
      View in: PubMed
    7. Radhakrishna SM, Grimm A, Broderick L. Novel mutation identified in severe early-onset tumor necrosis factor receptor-associated periodic syndrome: a case report. BMC Pediatr. 2017 04 20; 17(1):108. PMID: 28427379.
      View in: PubMed
    8. Hoffman HM, Broderick L. Editorial: It Just Takes One: Somatic Mosaicism in Autoinflammatory Disease. Arthritis Rheumatol. 2017 02; 69(2):253-256. PMID: 27748054.
      View in: PubMed
    9. Hoffman HM, Broderick L. The role of the inflammasome in patients with autoinflammatory diseases. J Allergy Clin Immunol. 2016 07; 138(1):3-14. PMID: 27373321.
      View in: PubMed
    10. Broderick L. Recurrent Fevers for the Pediatric Immunologist: It's Not All Immunodeficiency. Curr Allergy Asthma Rep. 2016 Jan; 16(1):2. PMID: 26707379.
      View in: PubMed
    11. Qu C, Bonar SL, Hickman-Brecks CL, Abu-Amer S, McGeough MD, Peña CA, Broderick L, Yang C, Grimston SK, Kading J, Abu-Amer Y, Novack DV, Hoffman HM, Civitelli R, Mbalaviele G. NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms. FASEB J. 2015 Apr; 29(4):1269-79. PMID: 25477279.
      View in: PubMed
    12. Broderick L, De Nardo D, Franklin BS, Hoffman HM, Latz E. The inflammasomes and autoinflammatory syndromes. Annu Rev Pathol. 2015; 10:395-424. PMID: 25423351.
      View in: PubMed
    13. Yu J, Nagasu H, Murakami T, Hoang H, Broderick L, Hoffman HM, Horng T. Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):15514-9. PMID: 25313054.
      View in: PubMed
    14. Broderick L, Hoffman HM. cASCading specks. Nat Immunol. 2014 Aug; 15(8):698-700. PMID: 25045869.
      View in: PubMed
    15. Brydges SD, Broderick L, McGeough MD, Pena CA, Mueller JL, Hoffman HM. Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies. J Clin Invest. 2013 Nov; 123(11):4695-705. PMID: 24084736.
      View in: PubMed
    16. Scott DR, Chan S, Chang J, Broderick L, Hoffman HM. Recurrent fevers and failure to thrive in an infant. Allergy Asthma Proc. 2013 Sep-Oct; 34(5):473-9. PMID: 23998246.
      View in: PubMed
    17. Wree A, Broderick L, Canbay A, Hoffman HM, Feldstein AE. From NAFLD to NASH to cirrhosis-new insights into disease mechanisms. Nat Rev Gastroenterol Hepatol. 2013 Nov; 10(11):627-36. PMID: 23958599.
      View in: PubMed
    18. Broderick L, Gandhi C, Mueller JL, Putnam CD, Shayan K, Giclas PC, Peterson KS, Aceves SS, Sheets RM, Peterson BM, Newbury RO, Hoffman HM, Bastian JF. Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis. J Clin Immunol. 2013 Jan; 33(1):162-71. PMID: 22926405.
      View in: PubMed
    19. McGeough MD, Pena CA, Mueller JL, Pociask DA, Broderick L, Hoffman HM, Brydges SD. Cutting edge: IL-6 is a marker of inflammation with no direct role in inflammasome-mediated mouse models. J Immunol. 2012 Sep 15; 189(6):2707-11. PMID: 22904305.
      View in: PubMed
    20. Broderick L, Tremoulet AH, Burns JC, Hoffman HM. Prolonged urticaria and fever in a toddler. Allergy Asthma Proc. 2012 May-Jun; 33(3):297-301. PMID: 22584197.
      View in: PubMed
    21. Broderick L, Tourangeau LM, Kavanaugh A, Wasserman SI. Biologic modulators in allergic and autoinflammatory diseases. Curr Opin Allergy Clin Immunol. 2011 Aug; 11(4):355-60. PMID: 21659854.
      View in: PubMed
    22. Broderick L, Tremoulet AH, Burns JC, Bastian JF, Hoffman HM. Recurrent fever syndromes in patients after recovery from Kawasaki syndrome. Pediatrics. 2011 Feb; 127(2):e489-93. PMID: 21220401.
      View in: PubMed
    23. Nazareth MR, Broderick L, Simpson-Abelson MR, Kelleher RJ, Yokota SJ, Bankert RB. Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells. J Immunol. 2007 May 01; 178(9):5552-62. PMID: 17442937.
      View in: PubMed
    24. Broderick L, Bankert RB. Membrane-associated TGF-beta1 inhibits human memory T cell signaling in malignant and nonmalignant inflammatory microenvironments. J Immunol. 2006 Sep 01; 177(5):3082-8. PMID: 16920945.
      View in: PubMed
    25. Broderick L, Yokota SJ, Reineke J, Mathiowitz E, Stewart CC, Barcos M, Kelleher RJ, Bankert RB. Human CD4+ effector memory T cells persisting in the microenvironment of lung cancer xenografts are activated by local delivery of IL-12 to proliferate, produce IFN-gamma, and eradicate tumor cells. J Immunol. 2005 Jan 15; 174(2):898-906. PMID: 15634912.
      View in: PubMed