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Lori Broderick

Title(s)Assistant Adjunct Professor, Pediatrics
SchoolHealth Sciences
Address9500 Gilman Drive #0760
La Jolla CA 92093
Phone858-534-1703
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    Collapse Research 
    Collapse Research Activities and Funding
    Molecular Genetics and Immunoregulatory mechanisms of PFAPA syndrome
    NIH/NICHD K08HD075830May 1, 2014 - Apr 30, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Immune Dysregulation in the Tonsillar Microenvironment of Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis (PFAPA) Syndrome. J Clin Immunol. 2020 Jan; 40(1):179-190. Luu I, Sharma A, Guaderrama M, Peru M, Nation J, Page N, Carvalho D, Magit A, Jiang W, Leuin S, Bliss M, Bothwell M, Brigger M, Kearns D, Newbury R, Pransky S, Gilbert JA, Broderick L. PMID: 31807979.
      View in: PubMed   Mentions:    Fields:    
    2. Mutations in topoisomerase IIß result in a B cell immunodeficiency. Nat Commun. 2019 08 13; 10(1):3644. Broderick L, Yost S, Li D, McGeough MD, Booshehri LM, Guaderrama M, Brydges SD, Kucharova K, Patel NC, Harr M, Hakonarson H, Zackai E, Cowell IG, Austin CA, Hügle B, Gebauer C, Zhang J, Xu X, Wang J, Croker BA, Frazer KA, Putnam CD, Hoffman HM. PMID: 31409799.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Alternative splicing regulates stochastic NLRP3 activity. Nat Commun. 2019 07 19; 10(1):3238. Hoss F, Mueller JL, Rojas Ringeling F, Rodriguez-Alcazar JF, Brinkschulte R, Seifert G, Stahl R, Broderick L, Putnam CD, Kolodner RD, Canzar S, Geyer M, Hoffman HM, Latz E. PMID: 31324763.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    4. Hereditary Autoinflammatory Disorders: Recognition and Treatment. Immunol Allergy Clin North Am. 2019 02; 39(1):13-29. Broderick L. PMID: 30466770.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. JAK inhibitors in autoinflammation. J Clin Invest. 2018 07 02; 128(7):2760-2762. Hoffman HM, Broderick L. PMID: 29889100.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies. J Clin Invest. 2017 12 01; 127(12):4488-4497. McGeough MD, Wree A, Inzaugarat ME, Haimovich A, Johnson CD, Peña CA, Goldbach-Mansky R, Broderick L, Feldstein AE, Hoffman HM. PMID: 29130929.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    7. NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy. Proc Natl Acad Sci U S A. 2017 09 12; 114(37):E7766-E7775. Nakanishi H, Kawashima Y, Kurima K, Chae JJ, Ross AM, Pinto-Patarroyo G, Patel SK, Muskett JA, Ratay JS, Chattaraj P, Park YH, Grevich S, Brewer CC, Hoa M, Kim HJ, Butman JA, Broderick L, Hoffman HM, Aksentijevich I, Kastner DL, Goldbach-Mansky R, Griffith AJ. PMID: 28847925.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    8. Novel mutation identified in severe early-onset tumor necrosis factor receptor-associated periodic syndrome: a case report. BMC Pediatr. 2017 04 20; 17(1):108. Radhakrishna SM, Grimm A, Broderick L. PMID: 28427379.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Editorial: It Just Takes One: Somatic Mosaicism in Autoinflammatory Disease. Arthritis Rheumatol. 2017 02; 69(2):253-256. Hoffman HM, Broderick L. PMID: 27748054.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    10. The role of the inflammasome in patients with autoinflammatory diseases. J Allergy Clin Immunol. 2016 07; 138(1):3-14. Hoffman HM, Broderick L. PMID: 27373321.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    11. Recurrent Fevers for the Pediatric Immunologist: It's Not All Immunodeficiency. Curr Allergy Asthma Rep. 2016 Jan; 16(1):2. Broderick L. PMID: 26707379.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms. FASEB J. 2015 Apr; 29(4):1269-79. Qu C, Bonar SL, Hickman-Brecks CL, Abu-Amer S, McGeough MD, Peña CA, Broderick L, Yang C, Grimston SK, Kading J, Abu-Amer Y, Novack DV, Hoffman HM, Civitelli R, Mbalaviele G. PMID: 25477279.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    13. The inflammasomes and autoinflammatory syndromes. Annu Rev Pathol. 2015; 10:395-424. Broderick L, De Nardo D, Franklin BS, Hoffman HM, Latz E. PMID: 25423351.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimals
    14. Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):15514-9. Yu J, Nagasu H, Murakami T, Hoang H, Broderick L, Hoffman HM, Horng T. PMID: 25313054.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    15. cASCading specks. Nat Immunol. 2014 Aug; 15(8):698-700. Broderick L, Hoffman HM. PMID: 25045869.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    16. Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies. J Clin Invest. 2013 Nov; 123(11):4695-705. Brydges SD, Broderick L, McGeough MD, Pena CA, Mueller JL, Hoffman HM. PMID: 24084736.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    17. Recurrent fevers and failure to thrive in an infant. Allergy Asthma Proc. 2013 Sep-Oct; 34(5):473-9. Scott DR, Chan S, Chang J, Broderick L, Hoffman HM. PMID: 23998246.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    18. From NAFLD to NASH to cirrhosis-new insights into disease mechanisms. Nat Rev Gastroenterol Hepatol. 2013 Nov; 10(11):627-36. Wree A, Broderick L, Canbay A, Hoffman HM, Feldstein AE. PMID: 23958599.
      View in: PubMed   Mentions: 123     Fields:    Translation:Humans
    19. Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis. J Clin Immunol. 2013 Jan; 33(1):162-71. Broderick L, Gandhi C, Mueller JL, Putnam CD, Shayan K, Giclas PC, Peterson KS, Aceves SS, Sheets RM, Peterson BM, Newbury RO, Hoffman HM, Bastian JF. PMID: 22926405.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    20. Cutting edge: IL-6 is a marker of inflammation with no direct role in inflammasome-mediated mouse models. J Immunol. 2012 Sep 15; 189(6):2707-11. McGeough MD, Pena CA, Mueller JL, Pociask DA, Broderick L, Hoffman HM, Brydges SD. PMID: 22904305.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    21. Prolonged urticaria and fever in a toddler. Allergy Asthma Proc. 2012 May-Jun; 33(3):297-301. Broderick L, Tremoulet AH, Burns JC, Hoffman HM. PMID: 22584197.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    22. Biologic modulators in allergic and autoinflammatory diseases. Curr Opin Allergy Clin Immunol. 2011 Aug; 11(4):355-60. Broderick L, Tourangeau LM, Kavanaugh A, Wasserman SI. PMID: 21659854.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    23. Recurrent fever syndromes in patients after recovery from Kawasaki syndrome. Pediatrics. 2011 Feb; 127(2):e489-93. Broderick L, Tremoulet AH, Burns JC, Bastian JF, Hoffman HM. PMID: 21220401.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    24. Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells. J Immunol. 2007 May 01; 178(9):5552-62. Nazareth MR, Broderick L, Simpson-Abelson MR, Kelleher RJ, Yokota SJ, Bankert RB. PMID: 17442937.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    25. Membrane-associated TGF-beta1 inhibits human memory T cell signaling in malignant and nonmalignant inflammatory microenvironments. J Immunol. 2006 Sep 01; 177(5):3082-8. Broderick L, Bankert RB. PMID: 16920945.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    26. Human CD4+ effector memory T cells persisting in the microenvironment of lung cancer xenografts are activated by local delivery of IL-12 to proliferate, produce IFN-gamma, and eradicate tumor cells. J Immunol. 2005 Jan 15; 174(2):898-906. Broderick L, Yokota SJ, Reineke J, Mathiowitz E, Stewart CC, Barcos M, Kelleher RJ, Bankert RB. PMID: 15634912.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells