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First reported case of a spontaneous and healthy pregnancy in a woman with persistent CAR T-cells 5 years after treatment for diffuse large B-cell lymphoma. J Immunother Cancer. 2025 Apr 01; 13(4).
Canty EA, Broderick L, Flaherty D, Xavier M, Nasta SD, Dajani L, White AA. PMID: 40169284; PMCID: PMC11962766.
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Humans
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Complement factor I deficiency: Diverse phenotypes. J Allergy Clin Immunol. 2025 Aug; 156(2):305-307.
Moreno R, Broderick L. PMID: 40127737.
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Disabling pansclerotic morphoea: a century of discovery. Br J Dermatol. 2025 Mar 18; 192(4):585-596.
Hua VK, Chang J, Laxer RM, Broderick L. PMID: 39520387.
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Humans
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The Saccharomyces cerevisiae cell lysis mutant cly8 is a temperature-sensitive allele of ESP1. bioRxiv. 2024 Oct 25.
Putnam CD, Li BZ, Broderick L. PMID: 39484378; PMCID: PMC11526885.
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Publisher Correction: IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting. Nat Rev Rheumatol. 2024 Jul; 20(7):452.
Broderick L, Hoffman HM. PMID: 38783116; PMCID: PMC11836985.
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PubMed Mentions: Fields:
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NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis. EMBO Rep. 2024 Jan; 25(1):455.
Kaufmann B, Leszczynska A, Reca A, Booshehri LM, Onyuru J, Tan Z, Wree A, Friess H, Hartmann D, Papouchado B, Broderick L, Hoffman HM, Croker BA, Zhu YP, Feldstein AE. PMID: 38216786; PMCID: PMC10897131.
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HumansAnimalsCells
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The discovery of NLRP3 and its function in cryopyrin-associated periodic syndromes and innate immunity. Immunol Rev. 2024 03; 322(1):259-282.
Putnam CD, Broderick L, Hoffman HM. PMID: 38146057; PMCID: PMC10950545.
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13 Fields:
Translation:
HumansAnimals
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Autoinflammatory syndromes: Updates in management. J Allergy Clin Immunol. 2024 01; 153(1):85-89.
Blackstone SA, Kastner DL, Broderick L. PMID: 37926121.
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1 Fields:
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Humans
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Variant STAT4 and Treatment of an Autoinflammatory Syndrome. Reply. N Engl J Med. 2023 09 21; 389(12):1151-1152.
Broderick L, Kastner DL. PMID: 37733321.
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Humans
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Antisense Oligonucleotide Therapy Decreases IL-1β Expression and Prolongs Survival in Mutant Nlrp3 Mice. J Immunol. 2023 07 15; 211(2):287-294.
Kaufmann B, de Los Reyes Jiménez M, Booshehri LM, Onyuru J, Leszczynska A, Uri A, Michel S, Klar R, Jaschinski F, Feldstein AE, Broderick L, Hoffman HM. PMID: 37256266.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Cold Urticaria Syndromes: Diagnosis and Management. J Allergy Clin Immunol Pract. 2023 08; 11(8):2275-2285.
Diaz VL, Gribbons KB, Yazdi-Nejad K, Kuemmerle-Deschner J, Wanderer AA, Broderick L, Hoffman HM. PMID: 37290539.
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3 Fields:
Translation:
Humans
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Variant STAT4 and Response to Ruxolitinib in an Autoinflammatory Syndrome. N Engl J Med. 2023 06 15; 388(24):2241-2252.
Baghdassarian H, Blackstone SA, Clay OS, Philips R, Matthiasardottir B, Nehrebecky M, Hua VK, McVicar R, Liu Y, Tucker SM, Randazzo D, Deuitch N, Rosenzweig S, Mark A, Sasik R, Fisch KM, Pimpale Chavan P, Eren E, Watts NR, Ma CA, Gadina M, Schwartz DM, Sanyal A, Werner G, Murdock DR, Horita N, Chowdhury S, Dimmock D, Jepsen K, Remmers EF, Goldbach-Mansky R, Gahl WA, O'Shea JJ, Milner JD, Lewis NE, Chang J, Kastner DL, Torok K, Oda H, Putnam CD, Broderick L. PMID: 37256972; PMCID: PMC10392571.
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21 Fields:
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Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis Syndrome and Syndrome of Unexplained Recurrent Fevers in Children and Adults. J Allergy Clin Immunol Pract. 2023 06; 11(6):1676-1687.
Hausmann J, Dedeoglu F, Broderick L. PMID: 36958521.
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6 Fields:
Translation:
Humans
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Mimickers of Classical Urticaria: Cryopyrin-Associated Autoinflammatory Syndrome Presenting as Isolated Urticaria in an Infant. J Allergy Clin Immunol Pract. 2023 03; 11(3):941-942.
Solomon BD, Skaljic M, Liu LY, Yan D, Sheahon KM, Broderick L, Hoffman HM, Beres SJ, Brown RA, Teng JMC, Gernez Y. PMID: 36720659.
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Humans
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Lentiviral Gene Therapy for Artemis-Deficient SCID. N Engl J Med. 2022 12 22; 387(25):2344-2355.
Cowan MJ, Yu J, Facchino J, Fraser-Browne C, Sanford U, Kawahara M, Dara J, Long-Boyle J, Oh J, Chan W, Chag S, Broderick L, Chellapandian D, Decaluwe H, Golski C, Hu D, Kuo CY, Miller HK, Petrovic A, Currier R, Hilton JF, Punwani D, Dvorak CC, Malech HL, McIvor RS, Puck JM. PMID: 36546626; PMCID: PMC9884487.
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PubMed Mentions:
22 Fields:
Translation:
HumansCellsCTClinical Trials
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NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis. EMBO Rep. 2022 11 07; 23(11):e54446.
Kaufmann B, Leszczynska A, Reca A, Booshehri LM, Onyuru J, Tan Z, Wree A, Friess H, Hartmann D, Papouchado B, Broderick L, Hoffman HM, Croker BA, Zhu YP, Feldstein AE. PMID: 36194627; PMCID: PMC9638850.
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25 Fields:
Translation:
AnimalsCells
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Cell-specific Deletion of NLRP3 Inflammasome Identifies Myeloid Cells as Key Drivers of Liver Inflammation and Fibrosis in Murine Steatohepatitis. Cell Mol Gastroenterol Hepatol. 2022; 14(4):751-767.
Kaufmann B, Kui L, Reca A, Leszczynska A, Kim AD, Booshehri LM, Wree A, Friess H, Hartmann D, Broderick L, Hoffman HM, Feldstein AE. PMID: 35787975; PMCID: PMC9424559.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting. Nat Rev Rheumatol. 2022 08; 18(8):448-463.
Broderick L, Hoffman HM. PMID: 35729334; PMCID: PMC9210802.
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PubMed Mentions:
55 Fields:
Translation:
HumansAnimals
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The 2021 EULAR/American College of Rheumatology Points to Consider for Diagnosis, Management and Monitoring of the Interleukin-1 Mediated Autoinflammatory Diseases: Cryopyrin-Associated Periodic Syndromes, Tumour Necrosis Factor Receptor-Associated Periodic Syndrome, Mevalonate Kinase Deficiency, and Deficiency of the Interleukin-1 Receptor Antagonist. Arthritis Rheumatol. 2022 07; 74(7):1102-1121.
Romano M, Arici ZS, Piskin D, Alehashemi S, Aletaha D, Barron K, Benseler S, Berard RA, Broderick L, Dedeoglu F, Diebold M, Durrant K, Ferguson P, Foell D, Hausmann JS, Jones OY, Kastner D, Lachmann HJ, Laxer RM, Rivera D, Ruperto N, Simon A, Twilt M, Frenkel J, Hoffman HM, de Jesus AA, Kuemmerle-Deschner JB, Ozen S, Gattorno M, Goldbach-Mansky R, Demirkaya E. PMID: 35621220; PMCID: PMC9531906.
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12 Fields:
Translation:
Humans
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The 2021 EULAR/American College of Rheumatology points to consider for diagnosis, management and monitoring of the interleukin-1 mediated autoinflammatory diseases: cryopyrin-associated periodic syndromes, tumour necrosis factor receptor-associated periodic syndrome, mevalonate kinase deficiency, and deficiency of the interleukin-1 receptor antagonist. Ann Rheum Dis. 2022 07; 81(7):907-921.
Romano M, Arici ZS, Piskin D, Alehashemi S, Aletaha D, Barron KS, Benseler S, Berard R, Broderick L, Dedeoglu F, Diebold M, Durrant KL, Ferguson P, Foell D, Hausmann J, Jones OY, Kastner DL, Lachmann HJ, Laxer RM, Rivera D, Ruperto N, Simon A, Twilt M, Frenkel J, Hoffman H, de Jesus AA, Kuemmerle-Deschner JB, Ozen S, Gattorno M, Goldbach-Mansky R, Demirkaya E. PMID: 35623638.
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49 Fields:
Translation:
Humans
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Disease-associated mutations in topoisomerase IIβ result in defective NK cells. J Allergy Clin Immunol. 2022 06; 149(6):2171-2176.e3.
Broderick L, Clay GM, Blum RH, Liu Y, McVicar R, Papes F, Booshehri LM, Cowell IG, Austin CA, Putnam CD, Kaufman DS. PMID: 35063500.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Immune response to intravenous immunoglobulin in patients with Kawasaki disease and MIS-C. J Clin Invest. 2021 10 15; 131(20).
Zhu YP, Shamie I, Lee JC, Nowell CJ, Peng W, Angulo S, Le LN, Liu Y, Miao H, Xiong H, Pena CJ, Moreno E, Griffis E, Labou SG, Franco A, Broderick L, Hoffman HM, Shimizu C, Lewis NE, Kanegaye JT, Tremoulet AH, Burns JC, Croker BA, Pediatric Emergency Medicine Kawasaki Disease Research Group Consortium. PMID: 34464357; PMCID: PMC8516453.
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34 Fields:
Translation:
HumansCells
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Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome. J Exp Med. 2021 10 04; 218(10).
Stackowicz J, Gaudenzio N, Serhan N, Conde E, Godon O, Marichal T, Starkl P, Balbino B, Roers A, Bruhns P, Jönsson F, Moguelet P, Georgin-Lavialle S, Broderick L, Hoffman HM, Galli SJ, Reber LL. PMID: 34477811; PMCID: PMC8421266.
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26 Fields:
Translation:
HumansAnimalsCells
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Undifferentiated recurrent fevers in pediatrics are clinically distinct from PFAPA syndrome but retain an IL-1 signature. Clin Immunol. 2021 05; 226:108697.
Luu I, Nation J, Page N, Carvalho D, Magit A, Jiang W, Leuin S, Bliss M, Bothwell M, Brigger M, Kearns D, Pransky S, Broderick L. PMID: 33636366; PMCID: PMC8089050.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Pediatric recurrent fever and autoinflammation from the perspective of an allergist/immunologist. J Allergy Clin Immunol. 2020 11; 146(5):960-966.e2.
Broderick L, Hoffman HM. PMID: 33002514; PMCID: PMC8559310.
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PubMed Mentions:
14 Fields:
Translation:
Humans
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Immune Dysregulation in the Tonsillar Microenvironment of Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis (PFAPA) Syndrome. J Clin Immunol. 2020 01; 40(1):179-190.
Luu I, Sharma A, Guaderrama M, Peru M, Nation J, Page N, Carvalho D, Magit A, Jiang W, Leuin S, Bliss M, Bothwell M, Brigger M, Kearns D, Newbury R, Pransky S, Gilbert JA, Broderick L. PMID: 31807979; PMCID: PMC7085444.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Mutations in topoisomerase IIβ result in a B cell immunodeficiency. Nat Commun. 2019 08 13; 10(1):3644.
Broderick L, Yost S, Li D, McGeough MD, Booshehri LM, Guaderrama M, Brydges SD, Kucharova K, Patel NC, Harr M, Hakonarson H, Zackai E, Cowell IG, Austin CA, Hügle B, Gebauer C, Zhang J, Xu X, Wang J, Croker BA, Frazer KA, Putnam CD, Hoffman HM. PMID: 31409799; PMCID: PMC6692411.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Alternative splicing regulates stochastic NLRP3 activity. Nat Commun. 2019 07 19; 10(1):3238.
Hoss F, Mueller JL, Rojas Ringeling F, Rodriguez-Alcazar JF, Brinkschulte R, Seifert G, Stahl R, Broderick L, Putnam CD, Kolodner RD, Canzar S, Geyer M, Hoffman HM, Latz E. PMID: 31324763; PMCID: PMC6642158.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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Hereditary Autoinflammatory Disorders: Recognition and Treatment. Immunol Allergy Clin North Am. 2019 02; 39(1):13-29.
Broderick L. PMID: 30466770.
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7 Fields:
Translation:
Humans
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JAK inhibitors in autoinflammation. J Clin Invest. 2018 07 02; 128(7):2760-2762.
Hoffman HM, Broderick L. PMID: 29889100; PMCID: PMC6025991.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies. J Clin Invest. 2017 12 01; 127(12):4488-4497.
McGeough MD, Wree A, Inzaugarat ME, Haimovich A, Johnson CD, Peña CA, Goldbach-Mansky R, Broderick L, Feldstein AE, Hoffman HM. PMID: 29130929; PMCID: PMC5707143.
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PubMed Mentions:
97 Fields:
Translation:
AnimalsCells
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NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy. Proc Natl Acad Sci U S A. 2017 09 12; 114(37):E7766-E7775.
Nakanishi H, Kawashima Y, Kurima K, Chae JJ, Ross AM, Pinto-Patarroyo G, Patel SK, Muskett JA, Ratay JS, Chattaraj P, Park YH, Grevich S, Brewer CC, Hoa M, Kim HJ, Butman JA, Broderick L, Hoffman HM, Aksentijevich I, Kastner DL, Goldbach-Mansky R, Griffith AJ. PMID: 28847925; PMCID: PMC5604003.
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PubMed Mentions:
78 Fields:
Translation:
HumansAnimalsCells
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Novel mutation identified in severe early-onset tumor necrosis factor receptor-associated periodic syndrome: a case report. BMC Pediatr. 2017 04 20; 17(1):108.
Radhakrishna SM, Grimm A, Broderick L. PMID: 28427379; PMCID: PMC5399385.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Editorial: It Just Takes One: Somatic Mosaicism in Autoinflammatory Disease. Arthritis Rheumatol. 2017 02; 69(2):253-256.
Hoffman HM, Broderick L. PMID: 27748054; PMCID: PMC5538189.
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PubMed Mentions:
13 Fields:
Translation:
Humans
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The role of the inflammasome in patients with autoinflammatory diseases. J Allergy Clin Immunol. 2016 07; 138(1):3-14.
Hoffman HM, Broderick L. PMID: 27373321.
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PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
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Recurrent Fevers for the Pediatric Immunologist: It's Not All Immunodeficiency. Curr Allergy Asthma Rep. 2016 Jan; 16(1):2.
Broderick L. PMID: 26707379.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms. FASEB J. 2015 Apr; 29(4):1269-79.
Qu C, Bonar SL, Hickman-Brecks CL, Abu-Amer S, McGeough MD, Peña CA, Broderick L, Yang C, Grimston SK, Kading J, Abu-Amer Y, Novack DV, Hoffman HM, Civitelli R, Mbalaviele G. PMID: 25477279; PMCID: PMC4396608.
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PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
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The inflammasomes and autoinflammatory syndromes. Annu Rev Pathol. 2015; 10:395-424.
Broderick L, De Nardo D, Franklin BS, Hoffman HM, Latz E. PMID: 25423351.
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PubMed Mentions:
150 Fields:
Translation:
HumansAnimals
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Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):15514-9.
Yu J, Nagasu H, Murakami T, Hoang H, Broderick L, Hoffman HM, Horng T. PMID: 25313054; PMCID: PMC4217429.
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PubMed Mentions:
255 Fields:
Translation:
HumansAnimalsCells
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cASCading specks. Nat Immunol. 2014 Aug; 15(8):698-700.
Broderick L, Hoffman HM. PMID: 25045869.
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PubMed Mentions:
11 Fields:
Translation:
Humans
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Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies. J Clin Invest. 2013 Nov; 123(11):4695-705.
Brydges SD, Broderick L, McGeough MD, Pena CA, Mueller JL, Hoffman HM. PMID: 24084736; PMCID: PMC3809806.
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PubMed Mentions:
121 Fields:
Translation:
HumansAnimalsCells
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Recurrent fevers and failure to thrive in an infant. Allergy Asthma Proc. 2013 Sep-Oct; 34(5):473-9.
Scott DR, Chan S, Chang J, Broderick L, Hoffman HM. PMID: 23998246; PMCID: PMC8242986.
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PubMed Mentions: Fields:
Translation:
HumansCells
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From NAFLD to NASH to cirrhosis-new insights into disease mechanisms. Nat Rev Gastroenterol Hepatol. 2013 Nov; 10(11):627-36.
Wree A, Broderick L, Canbay A, Hoffman HM, Feldstein AE. PMID: 23958599.
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PubMed Mentions:
294 Fields:
Translation:
Humans
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Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis. J Clin Immunol. 2013 Jan; 33(1):162-71.
Broderick L, Gandhi C, Mueller JL, Putnam CD, Shayan K, Giclas PC, Peterson KS, Aceves SS, Sheets RM, Peterson BM, Newbury RO, Hoffman HM, Bastian JF. PMID: 22926405; PMCID: PMC3540165.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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Cutting edge: IL-6 is a marker of inflammation with no direct role in inflammasome-mediated mouse models. J Immunol. 2012 Sep 15; 189(6):2707-11.
McGeough MD, Pena CA, Mueller JL, Pociask DA, Broderick L, Hoffman HM, Brydges SD. PMID: 22904305; PMCID: PMC3495128.
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PubMed Mentions:
49 Fields:
Translation:
Animals
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Biologic modulators in allergic and autoinflammatory diseases. Curr Opin Allergy Clin Immunol. 2011 Aug; 11(4):355-60.
Broderick L, Tourangeau LM, Kavanaugh A, Wasserman SI. PMID: 21659854; PMCID: PMC3154953.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Recurrent fever syndromes in patients after recovery from Kawasaki syndrome. Pediatrics. 2011 Feb; 127(2):e489-93.
Broderick L, Tremoulet AH, Burns JC, Bastian JF, Hoffman HM. PMID: 21220401; PMCID: PMC3025426.
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PubMed Mentions:
11 Fields:
Translation:
Humans
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Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells. J Immunol. 2007 May 01; 178(9):5552-62.
Nazareth MR, Broderick L, Simpson-Abelson MR, Kelleher RJ, Yokota SJ, Bankert RB. PMID: 17442937.
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PubMed Mentions:
145 Fields:
Translation:
HumansCells
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Membrane-associated TGF-beta1 inhibits human memory T cell signaling in malignant and nonmalignant inflammatory microenvironments. J Immunol. 2006 Sep 01; 177(5):3082-8.
Broderick L, Bankert RB. PMID: 16920945.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Human nasal polyp microenvironment maintained in viable and functional states as xenografts in SCID mice. Ann Otol Rhinol Laryngol. 2006 Jan; 115(1):65-73.
Bernstein JM, Broderick L, Parsons RR, Bankert RB. PMID: 16466102.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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IL-12 reverses anergy to T cell receptor triggering in human lung tumor-associated memory T cells. Clin Immunol. 2006 Feb-Mar; 118(2-3):159-69.
Broderick L, Brooks SP, Takita H, Baer AN, Bernstein JM, Bankert RB. PMID: 16271513.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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Human CD4+ effector memory T cells persisting in the microenvironment of lung cancer xenografts are activated by local delivery of IL-12 to proliferate, produce IFN-gamma, and eradicate tumor cells. J Immunol. 2005 Jan 15; 174(2):898-906.
Broderick L, Yokota SJ, Reineke J, Mathiowitz E, Stewart CC, Barcos M, Kelleher RJ, Bankert RB. PMID: 15634912.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells