Lori Broderick

Title(s)Associate Professor Of Clinical, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Molecular Genetics and Immunoregulatory mechanisms of PFAPA syndrome
    NIH K08HD075830May 1, 2014 - Apr 30, 2019
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis. EMBO Rep. 2024 Jan; 25(1):455. Kaufmann B, Leszczynska A, Reca A, Booshehri LM, Onyuru J, Tan Z, Wree A, Friess H, Hartmann D, Papouchado B, Broderick L, Hoffman HM, Croker BA, Zhu YP, Feldstein AE. PMID: 38216786; PMCID: PMC10897131.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. The discovery of NLRP3 and its function in cryopyrin-associated periodic syndromes and innate immunity. Immunol Rev. 2024 Mar; 322(1):259-282. Putnam CD, Broderick L, Hoffman HM. PMID: 38146057; PMCID: PMC10950545.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. Refractory Status Epilepticus Associated With a Pathogenic Variant in TNFRSF13B. Cureus. 2023 Nov; 15(11):e48222. Yang JH, Scanlon N, Woo W, LaBuzetta JN, Gonzalez C, Broderick L, Doherty T, Riedl M, Dunn-Pirio A. PMID: 38054159; PMCID: PMC10694393.
      View in: PubMed   Mentions:
    4. Variant STAT4 and Treatment of an Autoinflammatory Syndrome. Reply. N Engl J Med. 2023 Sep 21; 389(12):1151-1152. Broderick L, Kastner DL. PMID: 37733321.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Antisense Oligonucleotide Therapy Decreases IL-1β Expression and Prolongs Survival in Mutant Nlrp3 Mice. J Immunol. 2023 07 15; 211(2):287-294. Kaufmann B, de Los Reyes Jiménez M, Booshehri LM, Onyuru J, Leszczynska A, Uri A, Michel S, Klar R, Jaschinski F, Feldstein AE, Broderick L, Hoffman HM. PMID: 37256266.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    6. Cold Urticaria Syndromes: Diagnosis and Management. J Allergy Clin Immunol Pract. 2023 08; 11(8):2275-2285. Diaz VL, Gribbons KB, Yazdi-Nejad K, Kuemmerle-Deschner J, Wanderer AA, Broderick L, Hoffman HM. PMID: 37290539.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Variant STAT4 and Response to Ruxolitinib in an Autoinflammatory Syndrome. N Engl J Med. 2023 Jun 15; 388(24):2241-2252. Baghdassarian H, Blackstone SA, Clay OS, Philips R, Matthiasardottir B, Nehrebecky M, Hua VK, McVicar R, Liu Y, Tucker SM, Randazzo D, Deuitch N, Rosenzweig S, Mark A, Sasik R, Fisch KM, Pimpale Chavan P, Eren E, Watts NR, Ma CA, Gadina M, Schwartz DM, Sanyal A, Werner G, Murdock DR, Horita N, Chowdhury S, Dimmock D, Jepsen K, Remmers EF, Goldbach-Mansky R, Gahl WA, O'Shea JJ, Milner JD, Lewis NE, Chang J, Kastner DL, Torok K, Oda H, Putnam CD, Broderick L. PMID: 37256972; PMCID: PMC10392571.
      View in: PubMed   Mentions: 7     Fields:    
    8. Lentiviral Gene Therapy for Artemis-Deficient SCID. N Engl J Med. 2022 12 22; 387(25):2344-2355. Cowan MJ, Yu J, Facchino J, Fraser-Browne C, Sanford U, Kawahara M, Dara J, Long-Boyle J, Oh J, Chan W, Chag S, Broderick L, Chellapandian D, Decaluwe H, Golski C, Hu D, Kuo CY, Miller HK, Petrovic A, Currier R, Hilton JF, Punwani D, Dvorak CC, Malech HL, McIvor RS, Puck JM. PMID: 36546626; PMCID: PMC9884487.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCellsCTClinical Trials
    9. NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis. EMBO Rep. 2022 11 07; 23(11):e54446. Kaufmann B, Leszczynska A, Reca A, Booshehri LM, Onyuru J, Tan Z, Wree A, Friess H, Hartmann D, Papouchado B, Broderick L, Hoffman HM, Croker BA, Zhu YP, Feldstein AE. PMID: 36194627; PMCID: PMC9638850.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    10. Cell-specific Deletion of NLRP3 Inflammasome Identifies Myeloid Cells as Key Drivers of Liver Inflammation and Fibrosis in Murine Steatohepatitis. Cell Mol Gastroenterol Hepatol. 2022; 14(4):751-767. Kaufmann B, Kui L, Reca A, Leszczynska A, Kim AD, Booshehri LM, Wree A, Friess H, Hartmann D, Broderick L, Hoffman HM, Feldstein AE. PMID: 35787975; PMCID: PMC9424559.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    11. IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting. Nat Rev Rheumatol. 2022 08; 18(8):448-463. Broderick L, Hoffman HM. PMID: 35729334; PMCID: PMC9210802.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    12. Disease-associated mutations in topoisomerase IIβ result in defective NK cells. J Allergy Clin Immunol. 2022 06; 149(6):2171-2176.e3. Broderick L, Clay GM, Blum RH, Liu Y, McVicar R, Papes F, Booshehri LM, Cowell IG, Austin CA, Putnam CD, Kaufman DS. PMID: 35063500.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    13. Undifferentiated recurrent fevers in pediatrics are clinically distinct from PFAPA syndrome but retain an IL-1 signature. Clin Immunol. 2021 05; 226:108697. Luu I, Nation J, Page N, Carvalho D, Magit A, Jiang W, Leuin S, Bliss M, Bothwell M, Brigger M, Kearns D, Pransky S, Broderick L. PMID: 33636366; PMCID: PMC8089050.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    14. Pediatric recurrent fever and autoinflammation from the perspective of an allergist/immunologist. J Allergy Clin Immunol. 2020 11; 146(5):960-966.e2. Broderick L, Hoffman HM. PMID: 33002514; PMCID: PMC8559310.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    15. Immune Dysregulation in the Tonsillar Microenvironment of Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis (PFAPA) Syndrome. J Clin Immunol. 2020 01; 40(1):179-190. Luu I, Sharma A, Guaderrama M, Peru M, Nation J, Page N, Carvalho D, Magit A, Jiang W, Leuin S, Bliss M, Bothwell M, Brigger M, Kearns D, Newbury R, Pransky S, Gilbert JA, Broderick L. PMID: 31807979; PMCID: PMC7085444.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    16. Mutations in topoisomerase IIβ result in a B cell immunodeficiency. Nat Commun. 2019 08 13; 10(1):3644. Broderick L, Yost S, Li D, McGeough MD, Booshehri LM, Guaderrama M, Brydges SD, Kucharova K, Patel NC, Harr M, Hakonarson H, Zackai E, Cowell IG, Austin CA, Hügle B, Gebauer C, Zhang J, Xu X, Wang J, Croker BA, Frazer KA, Putnam CD, Hoffman HM. PMID: 31409799; PMCID: PMC6692411.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    17. Hereditary Autoinflammatory Disorders: Recognition and Treatment. Immunol Allergy Clin North Am. 2019 02; 39(1):13-29. Broderick L. PMID: 30466770.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    18. TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies. J Clin Invest. 2017 12 01; 127(12):4488-4497. McGeough MD, Wree A, Inzaugarat ME, Haimovich A, Johnson CD, Peña CA, Goldbach-Mansky R, Broderick L, Feldstein AE, Hoffman HM. PMID: 29130929; PMCID: PMC5707143.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    19. Novel mutation identified in severe early-onset tumor necrosis factor receptor-associated periodic syndrome: a case report. BMC Pediatr. 2017 04 20; 17(1):108. Radhakrishna SM, Grimm A, Broderick L. PMID: 28427379; PMCID: PMC5399385.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Editorial: It Just Takes One: Somatic Mosaicism in Autoinflammatory Disease. Arthritis Rheumatol. 2017 02; 69(2):253-256. Hoffman HM, Broderick L. PMID: 27748054; PMCID: PMC5538189.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    21. The role of the inflammasome in patients with autoinflammatory diseases. J Allergy Clin Immunol. 2016 07; 138(1):3-14. Hoffman HM, Broderick L. PMID: 27373321.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    22. Recurrent Fevers for the Pediatric Immunologist: It's Not All Immunodeficiency. Curr Allergy Asthma Rep. 2016 Jan; 16(1):2. Broderick L. PMID: 26707379.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms. FASEB J. 2015 Apr; 29(4):1269-79. Qu C, Bonar SL, Hickman-Brecks CL, Abu-Amer S, McGeough MD, Peña CA, Broderick L, Yang C, Grimston SK, Kading J, Abu-Amer Y, Novack DV, Hoffman HM, Civitelli R, Mbalaviele G. PMID: 25477279; PMCID: PMC4396608.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    24. cASCading specks. Nat Immunol. 2014 Aug; 15(8):698-700. Broderick L, Hoffman HM. PMID: 25045869.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    25. From NAFLD to NASH to cirrhosis-new insights into disease mechanisms. Nat Rev Gastroenterol Hepatol. 2013 Nov; 10(11):627-36. Wree A, Broderick L, Canbay A, Hoffman HM, Feldstein AE. PMID: 23958599.
      View in: PubMed   Mentions: 257     Fields:    Translation:Humans
    26. Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis. J Clin Immunol. 2013 Jan; 33(1):162-71. Broderick L, Gandhi C, Mueller JL, Putnam CD, Shayan K, Giclas PC, Peterson KS, Aceves SS, Sheets RM, Peterson BM, Newbury RO, Hoffman HM, Bastian JF. PMID: 22926405; PMCID: PMC3540165.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    27. Cutting edge: IL-6 is a marker of inflammation with no direct role in inflammasome-mediated mouse models. J Immunol. 2012 Sep 15; 189(6):2707-11. McGeough MD, Pena CA, Mueller JL, Pociask DA, Broderick L, Hoffman HM, Brydges SD. PMID: 22904305; PMCID: PMC3495128.
      View in: PubMed   Mentions: 41     Fields:    Translation:Animals
    28. Prolonged urticaria and fever in a toddler. Allergy Asthma Proc. 2012 May-Jun; 33(3):297-301. Broderick L, Tremoulet AH, Burns JC, Hoffman HM. PMID: 22584197; PMCID: PMC3490505.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    29. Biologic modulators in allergic and autoinflammatory diseases. Curr Opin Allergy Clin Immunol. 2011 Aug; 11(4):355-60. Broderick L, Tourangeau LM, Kavanaugh A, Wasserman SI. PMID: 21659854; PMCID: PMC3154953.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    30. Recurrent fever syndromes in patients after recovery from Kawasaki syndrome. Pediatrics. 2011 Feb; 127(2):e489-93. Broderick L, Tremoulet AH, Burns JC, Bastian JF, Hoffman HM. PMID: 21220401; PMCID: PMC3025426.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
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