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Lori Broderick

TitleAssistant Adjunct Professor
InstitutionUniversity of California San Diego
DepartmentPediatrics
Address9500 Gilman Drive #0760
La Jolla CA 92093
Phone858-534-1703
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    Collapse Research 
    Collapse Research Activities and Funding
    Molecular Genetics and Immunoregulatory mechanisms of PFAPA syndrome
    NIH K08HD075830May 1, 2014 - Apr 30, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hoffman HM, Broderick L. JAK inhibitors in autoinflammation. J Clin Invest. 2018 Jun 11. PMID: 29889100.
      View in: PubMed
    2. McGeough MD, Wree A, Inzaugarat ME, Haimovich A, Johnson CD, Peña CA, Goldbach-Mansky R, Broderick L, Feldstein AE, Hoffman HM. TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies. J Clin Invest. 2017 Dec 01; 127(12):4488-4497. PMID: 29130929.
      View in: PubMed
    3. Nakanishi H, Kawashima Y, Kurima K, Chae JJ, Ross AM, Pinto-Patarroyo G, Patel SK, Muskett JA, Ratay JS, Chattaraj P, Park YH, Grevich S, Brewer CC, Hoa M, Kim HJ, Butman JA, Broderick L, Hoffman HM, Aksentijevich I, Kastner DL, Goldbach-Mansky R, Griffith AJ. NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy. Proc Natl Acad Sci U S A. 2017 Sep 12; 114(37):E7766-E7775. PMID: 28847925.
      View in: PubMed
    4. Radhakrishna SM, Grimm A, Broderick L. Novel mutation identified in severe early-onset tumor necrosis factor receptor-associated periodic syndrome: a case report. BMC Pediatr. 2017 04 20; 17(1):108. PMID: 28427379.
      View in: PubMed
    5. Hoffman HM, Broderick L. Editorial: It Just Takes One: Somatic Mosaicism in Autoinflammatory Disease. Arthritis Rheumatol. 2017 Feb; 69(2):253-256. PMID: 27748054.
      View in: PubMed
    6. Hoffman HM, Broderick L. The role of the inflammasome in patients with autoinflammatory diseases. J Allergy Clin Immunol. 2016 Jul; 138(1):3-14. PMID: 27373321.
      View in: PubMed
    7. Broderick L. Recurrent Fevers for the Pediatric Immunologist: It's Not All Immunodeficiency. Curr Allergy Asthma Rep. 2016 Jan; 16(1):2. PMID: 26707379.
      View in: PubMed
    8. Qu C, Bonar SL, Hickman-Brecks CL, Abu-Amer S, McGeough MD, Peña CA, Broderick L, Yang C, Grimston SK, Kading J, Abu-Amer Y, Novack DV, Hoffman HM, Civitelli R, Mbalaviele G. NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms. FASEB J. 2015 Apr; 29(4):1269-79. PMID: 25477279; PMCID: PMC4396608.
    9. Broderick L, De Nardo D, Franklin BS, Hoffman HM, Latz E. The inflammasomes and autoinflammatory syndromes. Annu Rev Pathol. 2015; 10:395-424. PMID: 25423351.
      View in: PubMed
    10. Yu J, Nagasu H, Murakami T, Hoang H, Broderick L, Hoffman HM, Horng T. Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):15514-9. PMID: 25313054.
      View in: PubMed
    11. Broderick L, Hoffman HM. cASCading specks. Nat Immunol. 2014 Aug; 15(8):698-700. PMID: 25045869.
      View in: PubMed
    12. Brydges SD, Broderick L, McGeough MD, Pena CA, Mueller JL, Hoffman HM. Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies. J Clin Invest. 2013 Nov; 123(11):4695-705. PMID: 24084736; PMCID: PMC3809806.
    13. Scott DR, Chan S, Chang J, Broderick L, Hoffman HM. Recurrent fevers and failure to thrive in an infant. Allergy Asthma Proc. 2013 Sep-Oct; 34(5):473-9. PMID: 23998246.
      View in: PubMed
    14. Wree A, Broderick L, Canbay A, Hoffman HM, Feldstein AE. From NAFLD to NASH to cirrhosis-new insights into disease mechanisms. Nat Rev Gastroenterol Hepatol. 2013 Nov; 10(11):627-36. PMID: 23958599.
      View in: PubMed
    15. Broderick L, Gandhi C, Mueller JL, Putnam CD, Shayan K, Giclas PC, Peterson KS, Aceves SS, Sheets RM, Peterson BM, Newbury RO, Hoffman HM, Bastian JF. Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis. J Clin Immunol. 2013 Jan; 33(1):162-71. PMID: 22926405; PMCID: PMC3540165.
    16. McGeough MD, Pena CA, Mueller JL, Pociask DA, Broderick L, Hoffman HM, Brydges SD. Cutting edge: IL-6 is a marker of inflammation with no direct role in inflammasome-mediated mouse models. J Immunol. 2012 Sep 15; 189(6):2707-11. PMID: 22904305; PMCID: PMC3495128.
    17. Broderick L, Tremoulet AH, Burns JC, Hoffman HM. Prolonged urticaria and fever in a toddler. Allergy Asthma Proc. 2012 May-Jun; 33(3):297-301. PMID: 22584197; PMCID: PMC3490505.
    18. Broderick L, Tourangeau LM, Kavanaugh A, Wasserman SI. Biologic modulators in allergic and autoinflammatory diseases. Curr Opin Allergy Clin Immunol. 2011 Aug; 11(4):355-60. PMID: 21659854; PMCID: PMC3154953.
    19. Broderick L, Tremoulet AH, Burns JC, Bastian JF, Hoffman HM. Recurrent fever syndromes in patients after recovery from Kawasaki syndrome. Pediatrics. 2011 Feb; 127(2):e489-93. PMID: 21220401; PMCID: PMC3025426.
    20. Nazareth MR, Broderick L, Simpson-Abelson MR, Kelleher RJ, Yokota SJ, Bankert RB. Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells. J Immunol. 2007 May 01; 178(9):5552-62. PMID: 17442937.
      View in: PubMed
    21. Broderick L, Bankert RB. Membrane-associated TGF-beta1 inhibits human memory T cell signaling in malignant and nonmalignant inflammatory microenvironments. J Immunol. 2006 Sep 01; 177(5):3082-8. PMID: 16920945.
      View in: PubMed
    22. Broderick L, Yokota SJ, Reineke J, Mathiowitz E, Stewart CC, Barcos M, Kelleher RJ, Bankert RB. Human CD4+ effector memory T cells persisting in the microenvironment of lung cancer xenografts are activated by local delivery of IL-12 to proliferate, produce IFN-gamma, and eradicate tumor cells. J Immunol. 2005 Jan 15; 174(2):898-906. PMID: 15634912.
      View in: PubMed