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    Stefan Aigner

    TitleAssociate Project Scientist
    SchoolUniversity of California, San Diego
    DepartmentCellular and Molecular Medicine
    Address9500 Gilman Drive #0695
    CA La Jolla 92093
    Phone858-534-9322
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      Collapse Biography 
      Collapse Education and Training
      University of Colorado, BoulderPhD12/2003Chemistry and Biochemistry
      Collapse Awards and Honors
      The Salk Institute for Biological Studies2005  - 2008Damon Runyon Cancer Research Foundation Postdoctoral Fellowship

      Collapse Overview 
      Collapse Overview
      Stefan is an RNA biochemist, neuroscientist and stem cell biologist. Among his many responsibilities in the lab, he is the project coordinator for an NIH-funded U19 academic/industrial collaboration dubbed Copacabana (Collaboration On Preclinical Autism Cellular Assays, Biosignatures And Network Analyses), which is led by the Yeo lab and includes four other labs at UCSD and the Salk Institute, as well as Fluidigm and Allele Biotech as the industrial partners.
      Stefan received his PhD in Chemistry and Biochemistry from the University of Colorado at
      Boulder. In his thesis work in the lab of Tom Cech, he elucidated the role of p43, a protein subunit of telomerase from the ciliated model organism Euplotes. As a postdoctoral fellow of the Damon Runyon Cancer Research Foundation, Stefan joined the lab of Fred Gage at the Salk Institute to study transcriptional and post-transcriptional gene regulation in embryonic and adult neurogenesis. After brief but highly productive venture into the pharma industry, which led Stefan to Roche in Basel (Switzerland) to establish genome-editing based models of neurodevelopmental disorders, Stefan joined the Yeo lab as an Associate Project Scientist.


      Collapse Research 
      Collapse Research Activities and Funding
      Collaboration on preclinical autism cellular assays, biosignatures, and network analyses (Copacabana)
      NIH/NIMH U19MH107367Sep 21, 2015 - Jun 30, 2020
      Role: Project Coordinator

      Collapse ORNG Applications 
      Collapse Featured Publications
      Collapse Websites
      Collapse In The News

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Kathuria A, Nowosiad P, Jagasia R, Aigner S, Taylor RD, Andreae LC, Gatford NJF, Lucchesi W, Srivastava DP, Price J. Stem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development. Mol Psychiatry. 2017 Sep 26. PMID: 28948968.
        View in: PubMed
      2. Batra R, Nelles DA, Pirie E, Blue SM, Marina RJ, Wang H, Chaim IA, Thomas JD, Zhang N, Nguyen V, Aigner S, Markmiller S, Xia G, Corbett KD, Swanson MS, Yeo GW. Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9. Cell. 2017 Aug 24; 170(5):899-912.e10. PMID: 28803727.
        View in: PubMed
      3. Gündner AL, Meyer CA, Aigner S, Christensen K, Patsch C, Jagasia R, Baumann K, Burcin M. Generation of a homozygous GBA deletion human embryonic stem cell line. Stem Cell Res. 2017 Aug; 23:122-126. PMID: 28925361.
        View in: PubMed
      4. Lugert S, Kremer T, Jagasia R, Herrmann A, Aigner S, Giachino C, Mendez-David I, Gardier AM, Carralot JP, Meistermann H, Augustin A, Saxe MD, Lamerz J, Duran-Pacheco G, Ducret A, Taylor V, David DJ, Czech C. Glypican-2 levels in cerebrospinal fluid predict the status of adult hippocampal neurogenesis. Sci Rep. 2017 Apr 25; 7:46543. PMID: 28440309.
        View in: PubMed
      5. Kakaradov B, Arsenio J, Widjaja CE, He Z, Aigner S, Metz PJ, Yu B, Wehrens EJ, Lopez J, Kim SH, Zuniga EI, Goldrath AW, Chang JT, Yeo GW. Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing. Nat Immunol. 2017 Apr; 18(4):422-432. PMID: 28218746.
        View in: PubMed
      6. Batra R, Stark TJ, Clark E, Belzile JP, Wheeler EC, Yee BA, Huang H, Gelboin-Burkhart C, Huelga SC, Aigner S, Roberts BT, Bos TJ, Sathe S, Donohue JP, Rigo F, Ares M, Spector DH, Yeo GW. RNA-binding protein CPEB1 remodels host and viral RNA landscapes. Nat Struct Mol Biol. 2016 Dec; 23(12):1101-1110. PMID: 27775709.
        View in: PubMed
      7. Grabole N, Zhang JD, Aigner S, Ruderisch N, Costa V, Weber FC, Theron M, Berntenis N, Spleiss O, Ebeling M, Yeo GW, Jagasia R, Kiialainen A. Genomic analysis of the molecular neuropathology of tuberous sclerosis using a human stem cell model. Genome Med. 2016 Sep 21; 8(1):94. PMID: 27655340.
        View in: PubMed
      8. Conway AE, Van Nostrand EL, Pratt GA, Aigner S, Wilbert ML, Sundararaman B, Freese P, Lambert NJ, Sathe S, Liang TY, Essex A, Landais S, Burge CB, Jones DL, Yeo GW. Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival. Cell Rep. 2016 Apr 19; 15(3):666-679. PMID: 27068461; PMCID: PMC4839292.
      9. Costa V, Aigner S, Vukcevic M, Sauter E, Behr K, Ebeling M, Dunkley T, Friedlein A, Zoffmann S, Meyer CA, Knoflach F, Lugert S, Patsch C, Fjeldskaar F, Chicha-Gaudimier L, Kiialainen A, Piraino P, Bedoucha M, Graf M, Jessberger S, Ghosh A, Bischofberger J, Jagasia R. mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis. Cell Rep. 2016 Apr 05; 15(1):86-95. PMID: 27052171.
        View in: PubMed
      10. Bos TJ, Nussbacher JK, Aigner S, Yeo GW. Tethered Function Assays as Tools to Elucidate the Molecular Roles of RNA-Binding Proteins. Adv Exp Med Biol. 2016; 907:61-88. PMID: 27256382.
        View in: PubMed
      11. Dunkley T, Costa V, Friedlein A, Lugert S, Aigner S, Ebeling M, Miller MT, Patsch C, Piraino P, Cutler P, Jagasia R. Characterization of a human pluripotent stem cell-derived model of neuronal development using multiplexed targeted proteomics. Proteomics Clin Appl. 2015 Aug; 9(7-8):684-94. PMID: 25684324.
        View in: PubMed
      12. Nelles DA, Fang MY, Aigner S, Yeo GW. Applications of Cas9 as an RNA-programmed RNA-binding protein. Bioessays. 2015 Jul; 37(7):732-9. PMID: 25880497; PMCID: PMC4672944.
      13. Aigner S, Heckel T, Zhang JD, Andreae LC, Jagasia R. Human pluripotent stem cell models of autism spectrum disorder: emerging frontiers, opportunities, and challenges towards neuronal networks in a dish. Psychopharmacology (Berl). 2014 Mar; 231(6):1089-104. PMID: 24232378; PMCID: PMC3932166.
      14. Havlicek S, Kohl Z, Mishra HK, Prots I, Eberhardt E, Denguir N, Wend H, Plötz S, Boyer L, Marchetto MC, Aigner S, Sticht H, Groemer TW, Hehr U, Lampert A, Schlötzer-Schrehardt U, Winkler J, Gage FH, Winner B. Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons. Hum Mol Genet. 2014 May 15; 23(10):2527-41. PMID: 24381312; PMCID: PMC3990156.
      15. Vorstman JA, Spooren W, Persico AM, Collier DA, Aigner S, Jagasia R, Glennon JC, Buitelaar JK. Using genetic findings in autism for the development of new pharmaceutical compounds. Psychopharmacology (Berl). 2014 Mar; 231(6):1063-78. PMID: 24292384.
        View in: PubMed
      16. Urich E, Patsch C, Aigner S, Graf M, Iacone R, Freskgård PO. Multicellular self-assembled spheroidal model of the blood brain barrier. Sci Rep. 2013; 3:1500. PMID: 23511305; PMCID: PMC3603320.
      17. Bracko O, Singer T, Aigner S, Knobloch M, Winner B, Ray J, Clemenson GD, Suh H, Couillard-Despres S, Aigner L, Gage FH, Jessberger S. Gene expression profiling of neural stem cells and their neuronal progeny reveals IGF2 as a regulator of adult hippocampal neurogenesis. J Neurosci. 2012 Mar 07; 32(10):3376-87. PMID: 22399759; PMCID: PMC3338187.
      18. Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, Pham E, Masliah E, Gage FH, Riek R. In vivo demonstration that alpha-synuclein oligomers are toxic. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4194-9. PMID: 21325059; PMCID: PMC3053976.
      19. Thuret S, Toni N, Aigner S, Yeo GW, Gage FH. Hippocampus-dependent learning is associated with adult neurogenesis in MRL/MpJ mice. Hippocampus. 2009 Jul; 19(7):658-69. PMID: 19140178.
        View in: PubMed
      20. Lu YC, Smielewska M, Palakodeti D, Lovci MT, Aigner S, Yeo GW, Graveley BR. Deep sequencing identifies new and regulated microRNAs in Schmidtea mediterranea. RNA. 2009 Aug; 15(8):1483-91. PMID: 19553344; PMCID: PMC2714757.
      21. Jessberger S, Aigner S, Clemenson GD, Toni N, Lie DC, Karalay O, Overall R, Kempermann G, Gage FH. Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus. PLoS Biol. 2008 Nov 11; 6(11):e272. PMID: 18998770.
        View in: PubMed
      22. Yeo GW, Coufal N, Aigner S, Winner B, Scolnick JA, Marchetto MC, Muotri AR, Carson C, Gage FH. Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic stem cells. Hum Mol Genet. 2008 Apr 15; 17(R1):R67-75. PMID: 18632700.
        View in: PubMed
      23. Aigner S, Denli AM, Gage FH. A novel model for an older remodeler: the BAF swap in neurogenesis. Neuron. 2007 Jul 19; 55(2):171-3. PMID: 17640518.
        View in: PubMed
      24. Carson CT, Aigner S, Gage FH. Stem cells: the good, bad and barely in control. Nat Med. 2006 Nov; 12(11):1237-8. PMID: 17088886.
        View in: PubMed
      25. Aigner S, Gage FH. A small gem with great powers: geminin keeps neural progenitors thriving. Dev Cell. 2005 Aug; 9(2):171-2. PMID: 16054024.
        View in: PubMed
      26. Aigner S, Cech TR. The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro. RNA. 2004 Jul; 10(7):1108-18. PMID: 15208446; PMCID: PMC1370601.
      27. Aigner S, Postberg J, Lipps HJ, Cech TR. The Euplotes La motif protein p43 has properties of a telomerase-specific subunit. Biochemistry. 2003 May 20; 42(19):5736-47. PMID: 12741831.
        View in: PubMed
      28. Aigner S, Lingner J, Goodrich KJ, Grosshans CA, Shevchenko A, Mann M, Cech TR. Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting. EMBO J. 2000 Nov 15; 19(22):6230-9. PMID: 11080168; PMCID: PMC305813.
      29. Seiwert SD, Stines Nahreini T, Aigner S, Ahn NG, Uhlenbeck OC. RNA aptamers as pathway-specific MAP kinase inhibitors. Chem Biol. 2000 Nov; 7(11):833-43. PMID: 11094337.
        View in: PubMed
      30. Jabri E, Aigner S, Cech TR. Kinetic and secondary structure analysis of Naegleria andersoni GIR1, a group I ribozyme whose putative biological function is site-specific hydrolysis. Biochemistry. 1997 Dec 23; 36(51):16345-54. PMID: 9405070.
        View in: PubMed
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