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Stefan Aigner

Title(s)PROJ SCIENTIST-FY NON REP, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0695
La Jolla CA 92093
Phone8/5-34--9322
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    Collapse Biography 
    Collapse Education and Training
    University of Colorado, BoulderPhD12/2003Chemistry and Biochemistry
    Collapse Awards and Honors
    The Salk Institute for Biological Studies2005  - 2008Damon Runyon Cancer Research Foundation Postdoctoral Fellowship

    Collapse Overview 
    Collapse Overview
    Stefan is an RNA biochemist, neuroscientist and stem cell biologist. Among his many responsibilities in the lab, he is the project coordinator for an NIH-funded U19 academic/industrial collaboration dubbed Copacabana (Collaboration On Preclinical Autism Cellular Assays, Biosignatures And Network Analyses), which is led by the Yeo lab and includes four other labs at UCSD and the Salk Institute, as well as Fluidigm and Allele Biotech as the industrial partners.
    Stefan received his PhD in Chemistry and Biochemistry from the University of Colorado at
    Boulder. In his thesis work in the lab of Tom Cech, he elucidated the role of p43, a protein subunit of telomerase from the ciliated model organism Euplotes. As a postdoctoral fellow of the Damon Runyon Cancer Research Foundation, Stefan joined the lab of Fred Gage at the Salk Institute to study transcriptional and post-transcriptional gene regulation in embryonic and adult neurogenesis. After brief but highly productive venture into the pharma industry, which led Stefan to Roche in Basel (Switzerland) to establish genome-editing based models of neurodevelopmental disorders, Stefan joined the Yeo lab as an Associate Project Scientist.

    Collapse Research 
    Collapse Research Activities and Funding
    Collaboration on preclinical autism cellular assays, biosignatures, and network analyses (Copacabana)
    NIH/NIMH U19MH107367Jul 19, 2017 - Jun 30, 2020
    Role: Project Coordinator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Transcriptome-wide analysis of PGC-1a-binding RNAs identifies genes linked to glucagon metabolic action. Proc Natl Acad Sci U S A. 2020 Aug 26. Tavares CDJ, Aigner S, Sharabi K, Sathe S, Mutlu B, Yeo GW, Puigserver P. PMID: 32848060.
      View in: PubMed   Mentions:    Fields:    
    2. Large-scale tethered function assays identify factors that regulate mRNA stability and translation. Nat Struct Mol Biol. 2020 Aug 17. Luo EC, Nathanson JL, Tan FE, Schwartz JL, Schmok JC, Shankar A, Markmiller S, Yee BA, Sathe S, Pratt GA, Scaletta DB, Ha Y, Hill DE, Aigner S, Yeo GW. PMID: 32807991.
      View in: PubMed   Mentions:    Fields:    
    3. A large-scale binding and functional map of human RNA-binding proteins. Nature. 2020 Jul; 583(7818):711-719. Van Nostrand EL, Freese P, Pratt GA, Wang X, Wei X, Xiao R, Blue SM, Chen JY, Cody NAL, Dominguez D, Olson S, Sundararaman B, Zhan L, Bazile C, Bouvrette LPB, Bergalet J, Duff MO, Garcia KE, Gelboin-Burkhart C, Hochman M, Lambert NJ, Li H, McGurk MP, Nguyen TB, Palden T, Rabano I, Sathe S, Stanton R, Su A, Wang R, Yee BA, Zhou B, Louie AL, Aigner S, Fu XD, Lécuyer E, Burge CB, Graveley BR, Yeo GW. PMID: 32728246.
      View in: PubMed   Mentions: 1     Fields:    
    4. The Thermus thermophilus DEAD-box protein Hera is a general RNA binding protein and plays a key role in tRNA metabolism. RNA. 2020 Jul 15. Donsbach P, Yee BA, Sanchez-Hevia D, Berenguer J, Aigner S, Yeo GW, Klostermeier D. PMID: 32669294.
      View in: PubMed   Mentions:    Fields:    
    5. G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD. Neuron. 2020 Jul 08. Coyne AN, Zaepfel BL, Hayes L, Fitchman B, Salzberg Y, Luo EC, Bowen K, Trost H, Aigner S, Rigo F, Yeo GW, Harel A, Svendsen CN, Sareen D, Rothstein JD. PMID: 32673563.
      View in: PubMed   Mentions:    Fields:    
    6. The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis. Cell Stem Cell. 2019 11 07; 25(5):622-638.e13. Di Stefano B, Luo EC, Haggerty C, Aigner S, Charlton J, Brumbaugh J, Ji F, Rabano Jiménez I, Clowers KJ, Huebner AJ, Clement K, Lipchina I, de Kort MAC, Anselmo A, Pulice J, Gerli MFM, Gu H, Gygi SP, Sadreyev RI, Meissner A, Yeo GW, Hochedlinger K. PMID: 31588046.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    7. A Randomized, Crossover Study on the Effect of Food on the Pharmacokinetic Characteristics of Morphine ARER (MorphaBond™ ER), an Abuse-Deterrent Formulation of Extended-Release Morphine. Adv Ther. 2019 09; 36(9):2394-2401. Kinzler ER, Pantaleon C, Iverson M, Aigner S. PMID: 31278694.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Relative Oral Bioavailability of an Abuse-Deterrent, Immediate-Release Formulation of Oxycodone, Oxycodone ARIR in a Randomized Study. Adv Ther. 2019 07; 36(7):1730-1740. Webster LR, Kinzler ER, Pantaleon C, Iverson M, Aigner S. PMID: 31065992.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Syringeability of morphine ARER, a novel, abuse-deterrent, extended-release morphine formulation. Am J Drug Alcohol Abuse. 2019; 45(4):377-384. Kinzler ER, Pantaleon C, Iverson MS, Aigner S. PMID: 30990363.
      View in: PubMed   Mentions: 1     Fields:    
    10. A Randomized, Double-Blind, Double-Dummy, Placebo-Controlled, Intranasal Human Abuse Potential Study of Oxycodone ARIR, a Novel, Immediate-Release, Abuse-Deterrent Formulation. Pain Med. 2019 04 01; 20(4):747-757. Webster LR, Iverson M, Pantaleon C, Smith MD, Kinzler ER, Aigner S. PMID: 29608768.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Relative Oral Bioavailability of an Abuse-deterrent, Extended-release Formulation of Morphine Versus Extended-release Morphine: A 2-period, Single-dose, Randomized Crossover Study in Healthy Subjects. Clin Ther. 2018 08; 40(8):1357-1365. Kinzler ER, Pantaleon C, Aigner S. PMID: 30049503.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Intranasal Pharmacokinetics of Morphine ARER, a Novel Abuse-Deterrent Formulation: Results from a Randomized, Double-Blind, Four-Way Crossover Study in Nondependent, Opioid-Experienced Subjects. Pain Res Manag. 2018; 2018:7276021. Webster LR, Pantaleon C, Iverson M, Smith MD, Kinzler ER, Aigner S. PMID: 29849845.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Stem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development. Mol Psychiatry. 2018 03; 23(3):735-746. Kathuria A, Nowosiad P, Jagasia R, Aigner S, Taylor RD, Andreae LC, Gatford NJF, Lucchesi W, Srivastava DP, Price J. PMID: 28948968.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    14. Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9. Cell. 2017 Aug 24; 170(5):899-912.e10. Batra R, Nelles DA, Pirie E, Blue SM, Marina RJ, Wang H, Chaim IA, Thomas JD, Zhang N, Nguyen V, Aigner S, Markmiller S, Xia G, Corbett KD, Swanson MS, Yeo GW. PMID: 28803727.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    15. Generation of a homozygous GBA deletion human embryonic stem cell line. Stem Cell Res. 2017 08; 23:122-126. Gündner AL, Meyer CA, Aigner S, Christensen K, Patsch C, Jagasia R, Baumann K, Burcin M. PMID: 28925361.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    16. Glypican-2 levels in cerebrospinal fluid predict the status of adult hippocampal neurogenesis. Sci Rep. 2017 04 25; 7:46543. Lugert S, Kremer T, Jagasia R, Herrmann A, Aigner S, Giachino C, Mendez-David I, Gardier AM, Carralot JP, Meistermann H, Augustin A, Saxe MD, Lamerz J, Duran-Pacheco G, Ducret A, Taylor V, David DJ, Czech C. PMID: 28440309.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    17. Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing. Nat Immunol. 2017 04; 18(4):422-432. Kakaradov B, Arsenio J, Widjaja CE, He Z, Aigner S, Metz PJ, Yu B, Wehrens EJ, Lopez J, Kim SH, Zuniga EI, Goldrath AW, Chang JT, Yeo GW. PMID: 28218746.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    18. RNA-binding protein CPEB1 remodels host and viral RNA landscapes. Nat Struct Mol Biol. 2016 Dec; 23(12):1101-1110. Batra R, Stark TJ, Clark E, Belzile JP, Wheeler EC, Yee BA, Huang H, Gelboin-Burkhart C, Huelga SC, Aigner S, Roberts BT, Bos TJ, Sathe S, Donohue JP, Rigo F, Ares M, Spector DH, Yeo GW. PMID: 27775709.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    19. Genomic analysis of the molecular neuropathology of tuberous sclerosis using a human stem cell model. Genome Med. 2016 Sep 21; 8(1):94. Grabole N, Zhang JD, Aigner S, Ruderisch N, Costa V, Weber FC, Theron M, Berntenis N, Spleiss O, Ebeling M, Yeo GW, Jagasia R, Kiialainen A. PMID: 27655340.
      View in: PubMed   Mentions: 9     Fields:    
    20. Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival. Cell Rep. 2016 Apr 19; 15(3):666-679. Conway AE, Van Nostrand EL, Pratt GA, Aigner S, Wilbert ML, Sundararaman B, Freese P, Lambert NJ, Sathe S, Liang TY, Essex A, Landais S, Burge CB, Jones DL, Yeo GW. PMID: 27068461.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    21. mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis. Cell Rep. 2016 Apr 05; 15(1):86-95. Costa V, Aigner S, Vukcevic M, Sauter E, Behr K, Ebeling M, Dunkley T, Friedlein A, Zoffmann S, Meyer CA, Knoflach F, Lugert S, Patsch C, Fjeldskaar F, Chicha-Gaudimier L, Kiialainen A, Piraino P, Bedoucha M, Graf M, Jessberger S, Ghosh A, Bischofberger J, Jagasia R. PMID: 27052171.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    22. Tethered Function Assays as Tools to Elucidate the Molecular Roles of RNA-Binding Proteins. Adv Exp Med Biol. 2016; 907:61-88. Bos TJ, Nussbacher JK, Aigner S, Yeo GW. PMID: 27256382.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    23. Characterization of a human pluripotent stem cell-derived model of neuronal development using multiplexed targeted proteomics. Proteomics Clin Appl. 2015 Aug; 9(7-8):684-94. Dunkley T, Costa V, Friedlein A, Lugert S, Aigner S, Ebeling M, Miller MT, Patsch C, Piraino P, Cutler P, Jagasia R. PMID: 25684324.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    24. Applications of Cas9 as an RNA-programmed RNA-binding protein. Bioessays. 2015 Jul; 37(7):732-9. Nelles DA, Fang MY, Aigner S, Yeo GW. PMID: 25880497.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    25. Human pluripotent stem cell models of autism spectrum disorder: emerging frontiers, opportunities, and challenges towards neuronal networks in a dish. Psychopharmacology (Berl). 2014 Mar; 231(6):1089-104. Aigner S, Heckel T, Zhang JD, Andreae LC, Jagasia R. PMID: 24232378.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    26. Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons. Hum Mol Genet. 2014 May 15; 23(10):2527-41. Havlicek S, Kohl Z, Mishra HK, Prots I, Eberhardt E, Denguir N, Wend H, Plötz S, Boyer L, Marchetto MC, Aigner S, Sticht H, Groemer TW, Hehr U, Lampert A, Schlötzer-Schrehardt U, Winkler J, Gage FH, Winner B. PMID: 24381312.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    27. Using genetic findings in autism for the development of new pharmaceutical compounds. Psychopharmacology (Berl). 2014 Mar; 231(6):1063-78. Vorstman JA, Spooren W, Persico AM, Collier DA, Aigner S, Jagasia R, Glennon JC, Buitelaar JK. PMID: 24292384.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    28. Multicellular self-assembled spheroidal model of the blood brain barrier. Sci Rep. 2013; 3:1500. Urich E, Patsch C, Aigner S, Graf M, Iacone R, Freskgård PO. PMID: 23511305.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    29. Gene expression profiling of neural stem cells and their neuronal progeny reveals IGF2 as a regulator of adult hippocampal neurogenesis. J Neurosci. 2012 Mar 07; 32(10):3376-87. Bracko O, Singer T, Aigner S, Knobloch M, Winner B, Ray J, Clemenson GD, Suh H, Couillard-Despres S, Aigner L, Gage FH, Jessberger S. PMID: 22399759.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    30. In vivo demonstration that alpha-synuclein oligomers are toxic. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4194-9. Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, Pham E, Masliah E, Gage FH, Riek R. PMID: 21325059.
      View in: PubMed   Mentions: 362     Fields:    Translation:AnimalsCells
    31. Hippocampus-dependent learning is associated with adult neurogenesis in MRL/MpJ mice. Hippocampus. 2009 Jul; 19(7):658-69. Thuret S, Toni N, Aigner S, Yeo GW, Gage FH. PMID: 19140178.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    32. Deep sequencing identifies new and regulated microRNAs in Schmidtea mediterranea. RNA. 2009 Aug; 15(8):1483-91. Lu YC, Smielewska M, Palakodeti D, Lovci MT, Aigner S, Yeo GW, Graveley BR. PMID: 19553344.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    33. Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus. PLoS Biol. 2008 Nov 11; 6(11):e272. Jessberger S, Aigner S, Clemenson GD, Toni N, Lie DC, Karalay O, Overall R, Kempermann G, Gage FH. PMID: 18998770.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    34. Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic stem cells. Hum Mol Genet. 2008 Apr 15; 17(R1):R67-75. Yeo GW, Coufal N, Aigner S, Winner B, Scolnick JA, Marchetto MC, Muotri AR, Carson C, Gage FH. PMID: 18632700.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    35. A novel model for an older remodeler: the BAF swap in neurogenesis. Neuron. 2007 Jul 19; 55(2):171-3. Aigner S, Denli AM, Gage FH. PMID: 17640518.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    36. Stem cells: the good, bad and barely in control. Nat Med. 2006 Nov; 12(11):1237-8. Carson CT, Aigner S, Gage FH. PMID: 17088886.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    37. A small gem with great powers: geminin keeps neural progenitors thriving. Dev Cell. 2005 Aug; 9(2):171-2. Aigner S, Gage FH. PMID: 16054024.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    38. The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro. RNA. 2004 Jul; 10(7):1108-18. Aigner S, Cech TR. PMID: 15208446.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    39. The Euplotes La motif protein p43 has properties of a telomerase-specific subunit. Biochemistry. 2003 May 20; 42(19):5736-47. Aigner S, Postberg J, Lipps HJ, Cech TR. PMID: 12741831.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    40. Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting. EMBO J. 2000 Nov 15; 19(22):6230-9. Aigner S, Lingner J, Goodrich KJ, Grosshans CA, Shevchenko A, Mann M, Cech TR. PMID: 11080168.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    41. RNA aptamers as pathway-specific MAP kinase inhibitors. Chem Biol. 2000 Nov; 7(11):833-43. Seiwert SD, Stines Nahreini T, Aigner S, Ahn NG, Uhlenbeck OC. PMID: 11094337.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    42. Kinetic and secondary structure analysis of Naegleria andersoni GIR1, a group I ribozyme whose putative biological function is site-specific hydrolysis. Biochemistry. 1997 Dec 23; 36(51):16345-54. Jabri E, Aigner S, Cech TR. PMID: 9405070.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
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