Stefan Aigner

Title(s)PROJ SCIENTIST-FY NON REP, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    University of Colorado, BoulderPhD12/2003Chemistry and Biochemistry
    Collapse Awards and Honors
    The Salk Institute for Biological Studies2005  - 2008Damon Runyon Cancer Research Foundation Postdoctoral Fellowship

    Collapse Overview 
    Collapse Overview
    Stefan is an RNA biochemist, neuroscientist and stem cell biologist. Among his many responsibilities in the lab, he is the project coordinator for an NIH-funded U19 academic/industrial collaboration dubbed Copacabana (Collaboration On Preclinical Autism Cellular Assays, Biosignatures And Network Analyses), which is led by the Yeo lab and includes four other labs at UCSD and the Salk Institute, as well as Fluidigm and Allele Biotech as the industrial partners.
    Stefan received his PhD in Chemistry and Biochemistry from the University of Colorado at
    Boulder. In his thesis work in the lab of Tom Cech, he elucidated the role of p43, a protein subunit of telomerase from the ciliated model organism Euplotes. As a postdoctoral fellow of the Damon Runyon Cancer Research Foundation, Stefan joined the lab of Fred Gage at the Salk Institute to study transcriptional and post-transcriptional gene regulation in embryonic and adult neurogenesis. After brief but highly productive venture into the pharma industry, which led Stefan to Roche in Basel (Switzerland) to establish genome-editing based models of neurodevelopmental disorders, Stefan joined the Yeo lab as an Associate Project Scientist.

    Collapse Research 
    Collapse Research Activities and Funding
    Collaboration on preclinical autism cellular assays, biosignatures, and network analyses (Copacabana)
    NIH U19MH107367Sep 21, 2015 - Jun 30, 2021
    Role: Project Coordinator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A phage nucleus-associated RNA-binding protein is required for jumbo phage infection. Nucleic Acids Res. 2024 Mar 30. Enustun E, Armbruster EG, Lee J, Zhang S, Yee BA, Malukhina K, Gu Y, Deep A, Naritomi JT, Liang Q, Aigner S, Adler BA, Cress BF, Doudna JA, Chaikeeratisak V, Cleveland DW, Ghassemian M, Bintu B, Yeo GW, Pogliano J, Corbett KD. PMID: 38554115.
      View in: PubMed   Mentions:    Fields:    
    2. Transcriptome regulation by PARP13 in basal and antiviral states in human cells. iScience. 2024 Apr 19; 27(4):109251. Busa VF, Ando Y, Aigner S, Yee BA, Yeo GW, Leung AKL. PMID: 38495826; PMCID: PMC10943485.
      View in: PubMed   Mentions:
    3. Genomic surveillance reveals dynamic shifts in the connectivity of COVID-19 epidemics. Cell. 2023 12 21; 186(26):5690-5704.e20. Matteson NL, Hassler GW, Kurzban E, Schwab MA, Perkins SA, Gangavarapu K, Levy JI, Parker E, Pride D, Hakim A, De Hoff P, Cheung W, Castro-Martinez A, Rivera A, Veder A, Rivera A, Wauer C, Holmes J, Wilson J, Ngo SN, Plascencia A, Lawrence ES, Smoot EW, Eisner ER, Tsai R, Chacón M, Baer NA, Seaver P, Salido RA, Aigner S, Ngo TT, Barber T, Ostrander T, Fielding-Miller R, Simmons EH, Zazueta OE, Serafin-Higuera I, Sanchez-Alavez M, Moreno-Camacho JL, García-Gil A, Murphy Schafer AR, McDonald E, Corrigan J, Malone JD, Stous S, Shah S, Moshiri N, Weiss A, Anderson C, Aceves CM, Spencer EG, Hufbauer EC, Lee JJ, King AJ, Ramesh KS, Nguyen KN, Saucedo K, Robles-Sikisaka R, Fisch KM, Gonias SL, Birmingham A, McDonald D, Karthikeyan S, Martin NK, Schooley RT, Negrete AJ, Reyna HJ, Chavez JR, Garcia ML, Cornejo-Bravo JM, Becker D, Isaksson M, Washington NL, Lee W, Garfein RS, Luna-Ruiz Esparza MA, Alcántar-Fernández J, Henson B, Jepsen K, Olivares-Flores B, Barrera-Badillo G, Lopez-Martínez I, Ramírez-González JE, Flores-León R, Kingsmore SF, Sanders A, Pradenas A, White B, Matthews G, Hale M, McLawhon RW, Reed SL, Winbush T, McHardy IH, Fielding RA, Nicholson L, Quigley MM, Harding A, Mendoza A, Bakhtar O, Browne SH, Olivas Flores J, Rincon Rodríguez DG, Gonzalez Ibarra M, Robles Ibarra LC, Arellano Vera BJ, Gonzalez Garcia J, Harvey-Vera A, Knight R, Laurent LC, Yeo GW, Wertheim JO, Ji X, Worobey M, Suchard MA, Andersen KG, Campos-Romero A, Wohl S, Zeller M. PMID: 38101407; PMCID: PMC10795731.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    4. A phage nucleus-associated RNA-binding protein is required for jumbo phage infection. bioRxiv. 2023 Sep 22. Enustun E, Armbruster EG, Lee J, Zhang S, Yee BA, Gu Y, Deep A, Naritomi JT, Liang Q, Aigner S, Adler BA, Cress BF, Doudna JA, Chaikeeratisak V, Cleveland DW, Ghassemian M, Yeo GW, Pogliano J, Corbett KD. PMID: 37790334; PMCID: PMC10542519.
      View in: PubMed   Mentions:
    5. A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer. Nat Commun. 2023 09 06; 14(1):5195. Antal CE, Oh TG, Aigner S, Luo EC, Yee BA, Campos T, Tiriac H, Rothamel KL, Cheng Z, Jiao H, Wang A, Hah N, Lenkiewicz E, Lumibao JC, Truitt ML, Estepa G, Banayo E, Bashi S, Esparza E, Munoz RM, Diedrich JK, Sodir NM, Mueller JR, Fraser CR, Borazanci E, Propper D, Von Hoff DD, Liddle C, Yu RT, Atkins AR, Han H, Lowy AM, Barrett MT, Engle DD, Evan GI, Yeo GW, Downes M, Evans RM. PMID: 37673892; PMCID: PMC10482938.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. Pyruvate Kinase M (PKM) binds ribosomes in a poly-ADP ribosylation dependent manner to induce translational stalling. Nucleic Acids Res. 2023 07 07; 51(12):6461-6478. Kejiou NS, Ilan L, Aigner S, Luo E, Tonn T, Ozadam H, Lee M, Cole GB, Rabano I, Rajakulendran N, Yee BA, Najafabadi HS, Moraes TF, Angers S, Yeo GW, Cenik C, Palazzo AF. PMID: 37224531; PMCID: PMC10325899.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target. Blood Cancer Discov. 2023 05 01; 4(3):180-207. Vujovic A, de Rooij L, Chahi AK, Chen HT, Yee BA, Loganathan SK, Liu L, Chan DCH, Tajik A, Tsao E, Moreira S, Joshi P, Xu J, Wong N, Balde Z, Jahangiri S, Zandi S, Aigner S, Dick JE, Minden MD, Schramek D, Yeo GW, Hope KJ. PMID: 36763002; PMCID: PMC10150294.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Breastfeeding in Mothers with Multiple Sclerosis: The German Experience. Breastfeed Med. 2023 03; 18(3):241-245. Aigner S, Huhn K, Cepek L, Hellwig K, Nickel FT, Bayas A. PMID: 36795995.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission. Nature. 2022 09; 609(7925):101-108. Karthikeyan S, Levy JI, De Hoff P, Humphrey G, Birmingham A, Jepsen K, Farmer S, Tubb HM, Valles T, Tribelhorn CE, Tsai R, Aigner S, Sathe S, Moshiri N, Henson B, Mark AM, Hakim A, Baer NA, Barber T, Belda-Ferre P, Chacón M, Cheung W, Cresini ES, Eisner ER, Lastrella AL, Lawrence ES, Marotz CA, Ngo TT, Ostrander T, Plascencia A, Salido RA, Seaver P, Smoot EW, McDonald D, Neuhard RM, Scioscia AL, Satterlund AM, Simmons EH, Abelman DB, Brenner D, Bruner JC, Buckley A, Ellison M, Gattas J, Gonias SL, Hale M, Hawkins F, Ikeda L, Jhaveri H, Johnson T, Kellen V, Kremer B, Matthews G, McLawhon RW, Ouillet P, Park D, Pradenas A, Reed S, Riggs L, Sanders A, Sollenberger B, Song A, White B, Winbush T, Aceves CM, Anderson C, Gangavarapu K, Hufbauer E, Kurzban E, Lee J, Matteson NL, Parker E, Perkins SA, Ramesh KS, Robles-Sikisaka R, Schwab MA, Spencer E, Wohl S, Nicholson L, McHardy IH, Dimmock DP, Hobbs CA, Bakhtar O, Harding A, Mendoza A, Bolze A, Becker D, Cirulli ET, Isaksson M, Schiabor Barrett KM, Washington NL, Malone JD, Schafer AM, Gurfield N, Stous S, Fielding-Miller R, Garfein RS, Gaines T, Anderson C, Martin NK, Schooley R, Austin B, MacCannell DR, Kingsmore SF, Lee W, Shah S, McDonald E, Yu AT, Zeller M, Fisch KM, Longhurst C, Maysent P, Pride D, Khosla PK, Laurent LC, Yeo GW, Andersen KG, Knight R. PMID: 35798029; PMCID: PMC9433318.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansCellsPHPublic Health
    10. Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis. Acta Neuropathol. 2022 09; 144(3):413-435. Krach F, Wheeler EC, Regensburger M, Boerstler T, Wend H, Vu AQ, Wang R, Reischl S, Boldt K, Batra R, Aigner S, Ravits J, Winkler J, Yeo GW, Winner B. PMID: 35778567; PMCID: PMC9381448.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    11. Sentinel Cards Provide Practical SARS-CoV-2 Monitoring in School Settings. mSystems. 2022 08 30; 7(4):e0010922. Cantú VJ, Sanders K, Belda-Ferre P, Salido RA, Tsai R, Austin B, Jordan W, Asudani M, Walster A, Magallanes CG, Valentine H, Manjoonian A, Wijaya C, Omaleki V, Aigner S, Baer NA, Betty M, Castro-Martínez A, Cheung W, De Hoff P, Eisner E, Hakim A, Lastrella AL, Lawrence ES, Ngo TT, Ostrander T, Plascencia A, Sathe S, Smoot EW, Carlin AF, Yeo GW, Laurent LC, Manlutac AL, Fielding-Miller R, Knight R. PMID: 35703436; PMCID: PMC9426498.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    12. Implementation of Practical Surface SARS-CoV-2 Surveillance in School Settings. mSystems. 2022 08 30; 7(4):e0010322. Cantú VJ, Belda-Ferre P, Salido RA, Tsai R, Austin B, Jordan W, Asudani M, Walster A, Magallanes CG, Valentine H, Manjoonian A, Wijaya C, Omaleki V, Sanders K, Aigner S, Baer NA, Betty M, Castro-Martínez A, Cheung W, Crescini ES, De Hoff P, Eisner E, Hakim A, Kapadia B, Lastrella AL, Lawrence ES, Ngo TT, Ostrander T, Sathe S, Seaver P, Smoot EW, Carlin AF, Yeo GW, Laurent LC, Manlutac AL, Fielding-Miller R, Knight R. PMID: 35703437; PMCID: PMC9426517.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCellsPHPublic Health
    13. SARS-CoV-2 Distribution in Residential Housing Suggests Contact Deposition and Correlates with Rothia sp. mSystems. 2022 06 28; 7(3):e0141121. Cantú VJ, Salido RA, Huang S, Rahman G, Tsai R, Valentine H, Magallanes CG, Aigner S, Baer NA, Barber T, Belda-Ferre P, Betty M, Bryant M, Casas Maya M, Castro-Martínez A, Chacón M, Cheung W, Crescini ES, De Hoff P, Eisner E, Farmer S, Hakim A, Kohn L, Lastrella AL, Lawrence ES, Morgan SC, Ngo TT, Nouri A, Plascencia A, Ruiz CA, Sathe S, Seaver P, Shwartz T, Smoot EW, Ostrander RT, Valles T, Yeo GW, Laurent LC, Fielding-Miller R, Knight R. PMID: 35575492; PMCID: PMC9239251.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    14. Wastewater sequencing uncovers early, cryptic SARS-CoV-2 variant transmission. medRxiv. 2022 Apr 04. Karthikeyan S, Levy JI, De Hoff P, Humphrey G, Birmingham A, Jepsen K, Farmer S, Tubb HM, Valles T, Tribelhorn CE, Tsai R, Aigner S, Sathe S, Moshiri N, Henson B, Mark AM, Hakim A, Baer NA, Barber T, Belda-Ferre P, Chacón M, Cheung W, Cresini ES, Eisner ER, Lastrella AL, Lawrence ES, Marotz CA, Ngo TT, Ostrander T, Plascencia A, Salido RA, Seaver P, Smoot EW, McDonald D, Neuhard RM, Scioscia AL, Satterlund AM, Simmons EH, Abelman DB, Brenner D, Bruner JC, Buckley A, Ellison M, Gattas J, Gonias SL, Hale M, Hawkins F, Ikeda L, Jhaveri H, Johnson T, Kellen V, Kremer B, Matthews G, McLawhon RW, Ouillet P, Park D, Pradenas A, Reed S, Riggs L, Sanders A, Sollenberger B, Song A, White B, Winbush T, Aceves CM, Anderson C, Gangavarapu K, Hufbauer E, Kurzban E, Lee J, Matteson NL, Parker E, Perkins SA, Ramesh KS, Robles-Sikisaka R, Schwab MA, Spencer E, Wohl S, Nicholson L, Mchardy IH, Dimmock DP, Hobbs CA, Bakhtar O, Harding A, Mendoza A, Bolze A, Becker D, Cirulli ET, Isaksson M, Barrett KMS, Washington NL, Malone JD, Schafer AM, Gurfield N, Stous S, Fielding-Miller R, Garfein RS, Gaines T, Anderson C, Martin NK, Schooley R, Austin B, MacCannell DR, Kingsmore SF, Lee W, Shah S, McDonald E, Yu AT, Zeller M, Fisch KM, Longhurst C, Maysent P, Pride D, Khosla PK, Laurent LC, Yeo GW, Andersen KG, Knight R. PMID: 35411350; PMCID: PMC8996633.
      View in: PubMed   Mentions:
    15. Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML. Cell Rep. 2022 03 08; 38(10):110481. Krivdova G, Voisin V, Schoof EM, Marhon SA, Murison A, McLeod JL, Gabra MM, Zeng AGX, Aigner S, Yee BA, Shishkin AA, Van Nostrand EL, Hermans KG, Trotman-Grant AC, Mbong N, Kennedy JA, Gan OI, Wagenblast E, De Carvalho DD, Salmena L, Minden MD, Bader GD, Yeo GW, Dick JE, Lechman ER. PMID: 35263585.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    16. SARS-CoV-2 Distribution in Residential Housing Suggests Contact Deposition and Correlates with Rothia sp. medRxiv. 2021 Dec 07. Cantú VJ, Salido RA, Huang S, Rahman G, Tsai R, Valentine H, Magallanes CG, Aigner S, Baer NA, Barber T, Belda-Ferre P, Betty M, Bryant M, Maya MC, Castro-Martínez A, Chacón M, Cheung W, Crescini ES, De Hoff P, Eisner E, Farmer S, Hakim A, Kohn L, Lastrella AL, Lawrence ES, Morgan SC, Ngo TT, Nouri A, Ostrander RT, Plascencia A, Ruiz CA, Sathe S, Seaver P, Shwartz T, Smoot EW, Valles T, Yeo GW, Laurent LC, Fielding-Miller R, Knight R. PMID: 34909793; PMCID: PMC8669860.
      View in: PubMed   Mentions:
    17. Analysis of SARS-CoV-2 RNA Persistence across Indoor Surface Materials Reveals Best Practices for Environmental Monitoring Programs. mSystems. 2021 Dec 21; 6(6):e0113621. Salido RA, Cantú VJ, Clark AE, Leibel SL, Foroughishafiei A, Saha A, Hakim A, Nouri A, Lastrella AL, Castro-Martínez A, Plascencia A, Kapadia BK, Xia B, Ruiz CA, Marotz CA, Maunder D, Lawrence ES, Smoot EW, Eisner E, Crescini ES, Kohn L, Franco Vargas L, Chacón M, Betty M, Machnicki M, Wu MY, Baer NA, Belda-Ferre P, De Hoff P, Seaver P, Ostrander RT, Tsai R, Sathe S, Aigner S, Morgan SC, Ngo TT, Barber T, Cheung W, Carlin AF, Yeo GW, Laurent LC, Fielding-Miller R, Knight R. PMID: 34726486; PMCID: PMC8562474.
      View in: PubMed   Mentions: 10     Fields:    
    18. Emergence of an early SARS-CoV-2 epidemic in the United States. Cell. 2021 09 16; 184(19):4939-4952.e15. Zeller M, Gangavarapu K, Anderson C, Smither AR, Vanchiere JA, Rose R, Snyder DJ, Dudas G, Watts A, Matteson NL, Robles-Sikisaka R, Marshall M, Feehan AK, Sabino-Santos G, Bell-Kareem AR, Hughes LD, Alkuzweny M, Snarski P, Garcia-Diaz J, Scott RS, Melnik LI, Klitting R, McGraw M, Belda-Ferre P, DeHoff P, Sathe S, Marotz C, Grubaugh ND, Nolan DJ, Drouin AC, Genemaras KJ, Chao K, Topol S, Spencer E, Nicholson L, Aigner S, Yeo GW, Farnaes L, Hobbs CA, Laurent LC, Knight R, Hodcroft EB, Khan K, Fusco DN, Cooper VS, Lemey P, Gardner L, Lamers SL, Kamil JP, Garry RF, Suchard MA, Andersen KG. PMID: 34508652; PMCID: PMC8313480.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCellsPHPublic Health
    19. Comparison of heat-inactivated and infectious SARS-CoV-2 across indoor surface materials shows comparable RT-qPCR viral signal intensity and persistence. bioRxiv. 2021 Jul 19. Salido RA, Cantú VJ, Clark AE, Leibel SL, Foroughishafiei A, Saha A, Hakim A, Nouri A, Lastrella AL, Castro-Martínez A, Plascencia A, Kapadia B, Xia B, Ruiz C, Marotz CA, Maunder D, Lawrence ES, Smoot EW, Eisner E, Crescini ES, Kohn L, Vargas LF, Chacón M, Betty M, Machnicki M, Wu MY, Baer NA, Belda-Ferre P, Hoff P, Seaver P, Ostrander RT, Tsai R, Sathe S, Aigner S, Morgan SC, Ngo TT, Barber T, Cheung W, Carlin AF, Yeo GW, Laurent LC, Fielding-Miller R, Knight R. PMID: 34312621; PMCID: PMC8312891.
      View in: PubMed   Mentions:
    20. Emergence of an early SARS-CoV-2 epidemic in the United States. medRxiv. 2021 Feb 08. Zeller M, Gangavarapu K, Anderson C, Smither AR, Vanchiere JA, Rose R, Snyder DJ, Dudas G, Watts A, Matteson NL, Robles-Sikisaka R, Marshall M, Feehan AK, Sabino-Santos G, Bell-Kareem AR, Hughes LD, Alkuzweny M, Snarski P, Garcia-Diaz J, Scott RS, Melnik LI, Klitting R, McGraw M, Belda-Ferre P, DeHoff P, Sathe S, Marotz C, Grubaugh N, Nolan DJ, Drouin AC, Genemaras KJ, Chao K, Topol S, Spencer E, Nicholson L, Aigner S, Yeo GW, Farnaes L, Hobbs CA, Laurent LC, Knight R, Hodcroft EB, Khan K, Fusco DN, Cooper VS, Lemey P, Gardner L, Lamers SL, Kamil JP, Garry RF, Suchard MA, Andersen KG. PMID: 33564781; PMCID: PMC7872376.
      View in: PubMed   Mentions:
    21. Author Correction: A large-scale binding and functional map of human RNA-binding proteins. Nature. 2021 Jan; 589(7842):E5. Van Nostrand EL, Freese P, Pratt GA, Wang X, Wei X, Xiao R, Blue SM, Chen JY, Cody NAL, Dominguez D, Olson S, Sundararaman B, Zhan L, Bazile C, Bouvrette LPB, Bergalet J, Duff MO, Garcia KE, Gelboin-Burkhart C, Hochman M, Lambert NJ, Li H, McGurk MP, Nguyen TB, Palden T, Rabano I, Sathe S, Stanton R, Su A, Wang R, Yee BA, Zhou B, Louie AL, Aigner S, Fu XD, Lécuyer E, Burge CB, Graveley BR, Yeo GW. PMID: 33402748; PMCID: PMC7962576.
      View in: PubMed   Mentions: 3     Fields:    
    22. Transcriptome-wide profiles of circular RNA and RNA-binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression. Genome Med. 2020 12 07; 12(1):112. Okholm TLH, Sathe S, Park SS, Kamstrup AB, Rasmussen AM, Shankar A, Chua ZM, Fristrup N, Nielsen MM, Vang S, Dyrskjøt L, Aigner S, Damgaard CK, Yeo GW, Pedersen JS. PMID: 33287884; PMCID: PMC7722315.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    23. Handwashing and Detergent Treatment Greatly Reduce SARS-CoV-2 Viral Load on Halloween Candy Handled by COVID-19 Patients. mSystems. 2020 Oct 29; 5(6). Salido RA, Morgan SC, Rojas MI, Magallanes CG, Marotz C, DeHoff P, Belda-Ferre P, Aigner S, Kado DM, Yeo GW, Gilbert JA, Laurent L, Rohwer F, Knight R. PMID: 33127739; PMCID: PMC7743156.
      View in: PubMed   Mentions: 3     Fields:    
    24. Context-dependent functional compensation between Ythdf m6A reader proteins. Genes Dev. 2020 10 01; 34(19-20):1373-1391. Lasman L, Krupalnik V, Viukov S, Mor N, Aguilera-Castrejon A, Schneir D, Bayerl J, Mizrahi O, Peles S, Tawil S, Sathe S, Nachshon A, Shani T, Zerbib M, Kilimnik I, Aigner S, Shankar A, Mueller JR, Schwartz S, Stern-Ginossar N, Yeo GW, Geula S, Novershtern N, Hanna JH. PMID: 32943573; PMCID: PMC7528697.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    25. The sustained expression of Cas9 targeting toxic RNAs reverses disease phenotypes in mouse models of myotonic dystrophy type 1. Nat Biomed Eng. 2021 02; 5(2):157-168. Batra R, Nelles DA, Roth DM, Krach F, Nutter CA, Tadokoro T, Thomas JD, Sznajder LJ, Blue SM, Gutierrez HL, Liu P, Aigner S, Platoshyn O, Miyanohara A, Marsala M, Swanson MS, Yeo GW. PMID: 32929188; PMCID: PMC8241012.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    26. In vitro evaluation of a novel immediate-release formulation of oxy-codone (RoxyBond™) for the potential for abuse via injection. J Opioid Manag. 2020 Sep/Oct 2020; 16(5):383-390. Kinzler ER, Pantaleon C, Iverson M, Aigner S. PMID: 33226095.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. Transcriptome-wide analysis of PGC-1α-binding RNAs identifies genes linked to glucagon metabolic action. Proc Natl Acad Sci U S A. 2020 09 08; 117(36):22204-22213. Tavares CDJ, Aigner S, Sharabi K, Sathe S, Mutlu B, Yeo GW, Puigserver P. PMID: 32848060; PMCID: PMC7486754.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    28. Large-scale tethered function assays identify factors that regulate mRNA stability and translation. Nat Struct Mol Biol. 2020 10; 27(10):989-1000. Luo EC, Nathanson JL, Tan FE, Schwartz JL, Schmok JC, Shankar A, Markmiller S, Yee BA, Sathe S, Pratt GA, Scaletta DB, Ha Y, Hill DE, Aigner S, Yeo GW. PMID: 32807991; PMCID: PMC8221285.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    29. A large-scale binding and functional map of human RNA-binding proteins. Nature. 2020 07; 583(7818):711-719. Van Nostrand EL, Freese P, Pratt GA, Wang X, Wei X, Xiao R, Blue SM, Chen JY, Cody NAL, Dominguez D, Olson S, Sundararaman B, Zhan L, Bazile C, Bouvrette LPB, Bergalet J, Duff MO, Garcia KE, Gelboin-Burkhart C, Hochman M, Lambert NJ, Li H, McGurk MP, Nguyen TB, Palden T, Rabano I, Sathe S, Stanton R, Su A, Wang R, Yee BA, Zhou B, Louie AL, Aigner S, Fu XD, Lécuyer E, Burge CB, Graveley BR, Yeo GW. PMID: 32728246; PMCID: PMC7410833.
      View in: PubMed   Mentions: 379     Fields:    Translation:HumansCells
    30. The Thermus thermophilus DEAD-box protein Hera is a general RNA binding protein and plays a key role in tRNA metabolism. RNA. 2020 11; 26(11):1557-1574. Donsbach P, Yee BA, Sanchez-Hevia D, Berenguer J, Aigner S, Yeo GW, Klostermeier D. PMID: 32669294; PMCID: PMC7566566.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    31. G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD. Neuron. 2020 09 23; 107(6):1124-1140.e11. Coyne AN, Zaepfel BL, Hayes L, Fitchman B, Salzberg Y, Luo EC, Bowen K, Trost H, Aigner S, Rigo F, Yeo GW, Harel A, Svendsen CN, Sareen D, Rothstein JD. PMID: 32673563; PMCID: PMC8077944.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    32. The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis. Cell Stem Cell. 2019 11 07; 25(5):622-638.e13. Di Stefano B, Luo EC, Haggerty C, Aigner S, Charlton J, Brumbaugh J, Ji F, Rabano Jiménez I, Clowers KJ, Huebner AJ, Clement K, Lipchina I, de Kort MAC, Anselmo A, Pulice J, Gerli MFM, Gu H, Gygi SP, Sadreyev RI, Meissner A, Yeo GW, Hochedlinger K. PMID: 31588046; PMCID: PMC7247364.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    33. A Randomized, Crossover Study on the Effect of Food on the Pharmacokinetic Characteristics of Morphine ARER (MorphaBond™ ER), an Abuse-Deterrent Formulation of Extended-Release Morphine. Adv Ther. 2019 09; 36(9):2394-2401. Kinzler ER, Pantaleon C, Iverson M, Aigner S. PMID: 31278694; PMCID: PMC6822839.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. Relative Oral Bioavailability of an Abuse-Deterrent, Immediate-Release Formulation of Oxycodone, Oxycodone ARIR in a Randomized Study. Adv Ther. 2019 07; 36(7):1730-1740. Webster LR, Kinzler ER, Pantaleon C, Iverson M, Aigner S. PMID: 31065992; PMCID: PMC6824394.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    35. Syringeability of morphine ARER, a novel, abuse-deterrent, extended-release morphine formulation. Am J Drug Alcohol Abuse. 2019; 45(4):377-384. Kinzler ER, Pantaleon C, Iverson MS, Aigner S. PMID: 30990363.
      View in: PubMed   Mentions: 1     Fields:    
    36. A Randomized, Double-Blind, Double-Dummy, Placebo-Controlled, Intranasal Human Abuse Potential Study of Oxycodone ARIR, a Novel, Immediate-Release, Abuse-Deterrent Formulation. Pain Med. 2019 04 01; 20(4):747-757. Webster LR, Iverson M, Pantaleon C, Smith MD, Kinzler ER, Aigner S. PMID: 29608768; PMCID: PMC6542380.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    37. Relative Oral Bioavailability of an Abuse-deterrent, Extended-release Formulation of Morphine Versus Extended-release Morphine: A 2-period, Single-dose, Randomized Crossover Study in Healthy Subjects. Clin Ther. 2018 08; 40(8):1357-1365. Kinzler ER, Pantaleon C, Aigner S. PMID: 30049503.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    38. Intranasal Pharmacokinetics of Morphine ARER, a Novel Abuse-Deterrent Formulation: Results from a Randomized, Double-Blind, Four-Way Crossover Study in Nondependent, Opioid-Experienced Subjects. Pain Res Manag. 2018; 2018:7276021. Webster LR, Pantaleon C, Iverson M, Smith MD, Kinzler ER, Aigner S. PMID: 29849845; PMCID: PMC5937443.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    39. Stem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development. Mol Psychiatry. 2018 03; 23(3):735-746. Kathuria A, Nowosiad P, Jagasia R, Aigner S, Taylor RD, Andreae LC, Gatford NJF, Lucchesi W, Srivastava DP, Price J. PMID: 28948968; PMCID: PMC5822449.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    40. Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9. Cell. 2017 Aug 24; 170(5):899-912.e10. Batra R, Nelles DA, Pirie E, Blue SM, Marina RJ, Wang H, Chaim IA, Thomas JD, Zhang N, Nguyen V, Aigner S, Markmiller S, Xia G, Corbett KD, Swanson MS, Yeo GW. PMID: 28803727; PMCID: PMC5873302.
      View in: PubMed   Mentions: 120     Fields:    Translation:AnimalsCells
    41. Generation of a homozygous GBA deletion human embryonic stem cell line. Stem Cell Res. 2017 08; 23:122-126. Gündner AL, Meyer CA, Aigner S, Christensen K, Patsch C, Jagasia R, Baumann K, Burcin M. PMID: 28925361.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    42. Glypican-2 levels in cerebrospinal fluid predict the status of adult hippocampal neurogenesis. Sci Rep. 2017 04 25; 7:46543. Lugert S, Kremer T, Jagasia R, Herrmann A, Aigner S, Giachino C, Mendez-David I, Gardier AM, Carralot JP, Meistermann H, Augustin A, Saxe MD, Lamerz J, Duran-Pacheco G, Ducret A, Taylor V, David DJ, Czech C. PMID: 28440309; PMCID: PMC5404329.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    43. Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing. Nat Immunol. 2017 04; 18(4):422-432. Kakaradov B, Arsenio J, Widjaja CE, He Z, Aigner S, Metz PJ, Yu B, Wehrens EJ, Lopez J, Kim SH, Zuniga EI, Goldrath AW, Chang JT, Yeo GW. PMID: 28218746; PMCID: PMC5360497.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    44. RNA-binding protein CPEB1 remodels host and viral RNA landscapes. Nat Struct Mol Biol. 2016 12; 23(12):1101-1110. Batra R, Stark TJ, Clark AE, Belzile JP, Wheeler EC, Yee BA, Huang H, Gelboin-Burkhart C, Huelga SC, Aigner S, Roberts BT, Bos TJ, Sathe S, Donohue JP, Rigo F, Ares M, Spector DH, Yeo GW. PMID: 27775709; PMCID: PMC5140759.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    45. Genomic analysis of the molecular neuropathology of tuberous sclerosis using a human stem cell model. Genome Med. 2016 Sep 21; 8(1):94. Grabole N, Zhang JD, Aigner S, Ruderisch N, Costa V, Weber FC, Theron M, Berntenis N, Spleiss O, Ebeling M, Yeo GW, Jagasia R, Kiialainen A. PMID: 27655340; PMCID: PMC5031259.
      View in: PubMed   Mentions: 21     Fields:    
    46. Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival. Cell Rep. 2016 Apr 19; 15(3):666-679. Conway AE, Van Nostrand EL, Pratt GA, Aigner S, Wilbert ML, Sundararaman B, Freese P, Lambert NJ, Sathe S, Liang TY, Essex A, Landais S, Burge CB, Jones DL, Yeo GW. PMID: 27068461; PMCID: PMC4839292.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    47. mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis. Cell Rep. 2016 Apr 05; 15(1):86-95. Costa V, Aigner S, Vukcevic M, Sauter E, Behr K, Ebeling M, Dunkley T, Friedlein A, Zoffmann S, Meyer CA, Knoflach F, Lugert S, Patsch C, Fjeldskaar F, Chicha-Gaudimier L, Kiialainen A, Piraino P, Bedoucha M, Graf M, Jessberger S, Ghosh A, Bischofberger J, Jagasia R. PMID: 27052171.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    48. Tethered Function Assays as Tools to Elucidate the Molecular Roles of RNA-Binding Proteins. Adv Exp Med Biol. 2016; 907:61-88. Bos TJ, Nussbacher JK, Aigner S, Yeo GW. PMID: 27256382; PMCID: PMC5569382.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    49. Characterization of a human pluripotent stem cell-derived model of neuronal development using multiplexed targeted proteomics. Proteomics Clin Appl. 2015 Aug; 9(7-8):684-94. Dunkley T, Costa V, Friedlein A, Lugert S, Aigner S, Ebeling M, Miller MT, Patsch C, Piraino P, Cutler P, Jagasia R. PMID: 25684324.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    50. Applications of Cas9 as an RNA-programmed RNA-binding protein. Bioessays. 2015 Jul; 37(7):732-9. Nelles DA, Fang MY, Aigner S, Yeo GW. PMID: 25880497; PMCID: PMC4672944.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    51. Human pluripotent stem cell models of autism spectrum disorder: emerging frontiers, opportunities, and challenges towards neuronal networks in a dish. Psychopharmacology (Berl). 2014 Mar; 231(6):1089-104. Aigner S, Heckel T, Zhang JD, Andreae LC, Jagasia R. PMID: 24232378; PMCID: PMC3932166.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    52. Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons. Hum Mol Genet. 2014 May 15; 23(10):2527-41. Havlicek S, Kohl Z, Mishra HK, Prots I, Eberhardt E, Denguir N, Wend H, Plötz S, Boyer L, Marchetto MC, Aigner S, Sticht H, Groemer TW, Hehr U, Lampert A, Schlötzer-Schrehardt U, Winkler J, Gage FH, Winner B. PMID: 24381312; PMCID: PMC3990156.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    53. Using genetic findings in autism for the development of new pharmaceutical compounds. Psychopharmacology (Berl). 2014 Mar; 231(6):1063-78. Vorstman JA, Spooren W, Persico AM, Collier DA, Aigner S, Jagasia R, Glennon JC, Buitelaar JK. PMID: 24292384.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    54. Multicellular self-assembled spheroidal model of the blood brain barrier. Sci Rep. 2013; 3:1500. Urich E, Patsch C, Aigner S, Graf M, Iacone R, Freskgård PO. PMID: 23511305; PMCID: PMC3603320.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    55. Gene expression profiling of neural stem cells and their neuronal progeny reveals IGF2 as a regulator of adult hippocampal neurogenesis. J Neurosci. 2012 Mar 07; 32(10):3376-87. Bracko O, Singer T, Aigner S, Knobloch M, Winner B, Ray J, Clemenson GD, Suh H, Couillard-Despres S, Aigner L, Gage FH, Jessberger S. PMID: 22399759; PMCID: PMC3338187.
      View in: PubMed   Mentions: 103     Fields:    Translation:AnimalsCells
    56. In vivo demonstration that alpha-synuclein oligomers are toxic. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4194-9. Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, Pham E, Masliah E, Gage FH, Riek R. PMID: 21325059; PMCID: PMC3053976.
      View in: PubMed   Mentions: 642     Fields:    Translation:AnimalsCells
    57. Hippocampus-dependent learning is associated with adult neurogenesis in MRL/MpJ mice. Hippocampus. 2009 Jul; 19(7):658-69. Thuret S, Toni N, Aigner S, Yeo GW, Gage FH. PMID: 19140178.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    58. Deep sequencing identifies new and regulated microRNAs in Schmidtea mediterranea. RNA. 2009 Aug; 15(8):1483-91. Lu YC, Smielewska M, Palakodeti D, Lovci MT, Aigner S, Yeo GW, Graveley BR. PMID: 19553344; PMCID: PMC2714757.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    59. Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus. PLoS Biol. 2008 Nov 11; 6(11):e272. Jessberger S, Aigner S, Clemenson GD, Toni N, Lie DC, Karalay O, Overall R, Kempermann G, Gage FH. PMID: 18998770; PMCID: PMC2581629.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    60. Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic stem cells. Hum Mol Genet. 2008 Apr 15; 17(R1):R67-75. Yeo GW, Coufal N, Aigner S, Winner B, Scolnick JA, Marchetto MC, Muotri AR, Carson C, Gage FH. PMID: 18632700.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    61. A novel model for an older remodeler: the BAF swap in neurogenesis. Neuron. 2007 Jul 19; 55(2):171-3. Aigner S, Denli AM, Gage FH. PMID: 17640518.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    62. Stem cells: the good, bad and barely in control. Nat Med. 2006 Nov; 12(11):1237-8. Carson CT, Aigner S, Gage FH. PMID: 17088886.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    63. A small gem with great powers: geminin keeps neural progenitors thriving. Dev Cell. 2005 Aug; 9(2):171-2. Aigner S, Gage FH. PMID: 16054024.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    64. The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro. RNA. 2004 Jul; 10(7):1108-18. Aigner S, Cech TR. PMID: 15208446; PMCID: PMC1370601.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    65. The Euplotes La motif protein p43 has properties of a telomerase-specific subunit. Biochemistry. 2003 May 20; 42(19):5736-47. Aigner S, Postberg J, Lipps HJ, Cech TR. PMID: 12741831.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    66. Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting. EMBO J. 2000 Nov 15; 19(22):6230-9. Aigner S, Lingner J, Goodrich KJ, Grosshans CA, Shevchenko A, Mann M, Cech TR. PMID: 11080168; PMCID: PMC305813.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    67. RNA aptamers as pathway-specific MAP kinase inhibitors. Chem Biol. 2000 Nov; 7(11):833-43. Seiwert SD, Stines Nahreini T, Aigner S, Ahn NG, Uhlenbeck OC. PMID: 11094337.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    68. Kinetic and secondary structure analysis of Naegleria andersoni GIR1, a group I ribozyme whose putative biological function is site-specific hydrolysis. Biochemistry. 1997 Dec 23; 36(51):16345-54. Jabri E, Aigner S, Cech TR. PMID: 9405070.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
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