Alfredo Molinolo

Title(s)Adjunct Professor, Pathology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Correction: a phase 1b study of zilovertamab in combination with paclitaxel for locally advanced/unresectable or metastatic HER2-negative breast cancer. Breast Cancer Res. 2024 Mar 13; 26(1):46. Shatsky RA, Batra-Sharma H, Helsten T, Schwab RB, Pittman EI, Pu M, Weihe E, Ghia EM, Rassenti LZ, Molinolo A, Cabrera B, Breitmeyer JB, Widhopf Ii GF, Messer K, Jamieson C, Kipps TJ, Parker BA. PMID: 38481291; PMCID: PMC10938766.
      View in: PubMed   Mentions:    Fields:    
    2. A phase 1b study of zilovertamab in combination with paclitaxel for locally advanced/unresectable or metastatic Her2-negative breast cancer. Breast Cancer Res. 2024 02 26; 26(1):32. Shatsky RA, Batra-Sharma H, Helsten T, Schwab RB, Pittman EI, Pu M, Weihe E, Ghia EM, Rassenti LZ, Molinolo A, Cabrera B, Breitmeyer JB, Widhopf GF, Messer K, Jamieson C, Kipps TJ, Parker BA. PMID: 38408999; PMCID: PMC10895766.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    3. RNF185 Control of COL3A1 Expression Limits Prostate Cancer Migration and Metastatic Potential. Mol Cancer Res. 2024 Jan 02; 22(1):41-54. Van Espen B, Oo HZ, Collins C, Fazli L, Molinolo A, Yip K, Murad R, Gleave M, Ronai ZA. PMID: 37831068; PMCID: PMC10841372.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    4. YAP-Driven Malignant Reprogramming of Epithelial Stem Cells at Single Cell Resolution. Res Sq. 2023 Oct 27. Gutkind JS, Faraji F, Ramirez S, Clubb L, Sato K, Quiroz PA, Galloway W, Mikulski Z, Hoang T, Medetgul-Ernar K, Marangoni P, Jones K, Officer A, Molinolo A, Kim K, Sakaguchi K, Califano J, Smith Q, Klein O, Tamayo P. PMID: 37961717; PMCID: PMC10635308.
      View in: PubMed   Mentions:
    5. High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma. Cell Rep Med. 2023 11 21; 4(11):101244. Arang N, Lubrano S, Ceribelli M, Rigiracciolo DC, Saddawi-Konefka R, Faraji F, Ramirez SI, Kim D, Tosto FA, Stevenson E, Zhou Y, Wang Z, Bogomolovas J, Molinolo AA, Swaney DL, Krogan NJ, Yang J, Coma S, Pachter JA, Aplin AE, Alessi DR, Thomas CJ, Gutkind JS. PMID: 37858338; PMCID: PMC10694608.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    6. A Network Landscape of HPVOPC Reveals Methylation Alterations as Significant Drivers of Gene Expression via an Immune-Mediated GPCR Signal. Cancers (Basel). 2023 Sep 01; 15(17). Qualliotine JR, Nakagawa T, Rosenthal SB, Sadat S, Ballesteros-Merino C, Xu G, Mark A, Nasamran A, Gutkind JS, Fisch KM, Guo T, Fox BA, Khan Z, Molinolo AA, Califano JA. PMID: 37686653; PMCID: PMC10486378.
      View in: PubMed   Mentions:
    7. Direct reprogramming of oral epithelial progenitor cells to cancer stem cells at single cell resolution in vivo. bioRxiv. 2023 Jul 26. Faraji F, Ramirez SI, Clubb LM, Sato K, Quiroz PYA, Galloway WMG, Mikulski Z, Hoang TS, Medetgul-Ernar K, Marangoni P, Jones KB, Officer A, Molinolo AA, Kim K, Sakaguchi K, Califano JA, Smith Q, Klein OD, Tamayo P, Gutkind JS. PMID: 37546810; PMCID: PMC10402053.
      View in: PubMed   Mentions:
    8. RNF185 control of COL3A1 expression limits prostate cancer migration and metastatic potential. bioRxiv. 2023 Jul 01. Van Espen B, Oo HZ, Collins C, Fazli L, Molinolo A, Murad R, Gleave M, Ronai ZA. PMID: 37425866; PMCID: PMC10327057.
      View in: PubMed   Mentions:
    9. Ubiquitin Ligases Siah1a/2 Control Alveolar Macrophage Functions to Limit Carcinogen-Induced Lung Adenocarcinoma. Cancer Res. 2023 06 15; 83(12):2016-2033. Scortegagna M, Du Y, Bradley LM, Wang K, Molinolo A, Ruppin E, Murad R, Ronai ZA. PMID: 37078793; PMCID: PMC10330299.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. Immunohistochemical Techniques for Phosphoproteins. Methods Mol Biol. 2023; 2593:259-264. Sanz Ressel BL, Molinolo AA. PMID: 36513937.
      View in: PubMed   Mentions:    Fields:    
    11. Lymphatic-preserving treatment sequencing with immune checkpoint inhibition unleashes cDC1-dependent antitumor immunity in HNSCC. Nat Commun. 2022 07 25; 13(1):4298. Saddawi-Konefka R, O'Farrell A, Faraji F, Clubb L, Allevato MM, Jensen SM, Yung BS, Wang Z, Wu VH, Anang NA, Msari RA, Schokrpur S, Pietryga IF, Molinolo AA, Mesirov JP, Simon AB, Fox BA, Bui JD, Sharabi A, Cohen EEW, Califano JA, Gutkind JS. PMID: 35879302; PMCID: PMC9314425.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    12. Monomethyl auristatin antibody and peptide drug conjugates for trimodal cancer chemo-radio-immunotherapy. Nat Commun. 2022 07 05; 13(1):3869. Hingorani DV, Allevato MM, Camargo MF, Lesperance J, Quraishi MA, Aguilera J, Franiak-Pietryga I, Scanderbeg DJ, Wang Z, Molinolo AA, Alvarado D, Sharabi AB, Bui JD, Cohen EEW, Adams SR, Gutkind JS, Advani SJ. PMID: 35790753; PMCID: PMC9256669.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    13. Tumor FAK orchestrates immunosuppression in ovarian cancer via the CD155/TIGIT axis. Proc Natl Acad Sci U S A. 2022 04 26; 119(17):e2117065119. Ozmadenci D, Shankara Narayanan JS, Andrew J, Ojalill M, Barrie AM, Jiang S, Iyer S, Chen XL, Rose M, Estrada V, Molinolo A, Bertotto T, Mikulski Z, McHale MC, White RR, Connolly DC, Pachter JA, Kuchroo VK, Stupack DG, Schlaepfer DD. PMID: 35467979; PMCID: PMC9169934.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    14. Progesterone receptor isoform ratio dictates antiprogestin/progestin effects on breast cancer growth and metastases: A role for NDRG1. Int J Cancer. 2022 05 01; 150(9):1481-1496. Abascal MF, Elia A, Alvarez M, Pataccini G, Sequeira G, Riggio M, Figueroa V, Lamb CA, Rojas PA, Spengler E, Martínez-Vazquez P, Burruchaga J, Liguori M, Sahores A, Wargon V, Molinolo A, Hewitt S, Lombes M, Sartorius C, Vanzulli SI, Giulianelli S, Lanari C. PMID: 34935137.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    15. Inhibition of mTOR signaling and clinical activity of metformin in oral premalignant lesions. JCI Insight. 2021 09 08; 6(17). Gutkind JS, Molinolo AA, Wu X, Wang Z, Nachmanson D, Harismendy O, Alexandrov LB, Wuertz BR, Ondrey FG, Laronde D, Rock LD, Rosin M, Coffey C, Butler VD, Bengtson L, Hsu CH, Bauman JE, Hewitt SM, Cohen EE, Chow HS, Lippman SM, Szabo E. PMID: 34255745; PMCID: PMC8492350.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCellsCTClinical Trials
    16. Vulnerabilities of Cancer Patients and Their Effects on Informed Consent for Biobanking. Biopreserv Biobank. 2021 12; 19(6):543-548. Kyle M, Cortez D, Carbonell B, Masmila E, Molinolo A, Kaushal S. PMID: 34348031.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Pembrolizumab plus cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma: an open-label, multi-arm, non-randomised, multicentre, phase 2 trial. Lancet Oncol. 2021 06; 22(6):883-892. Sacco AG, Chen R, Worden FP, Wong DJL, Adkins D, Swiecicki P, Chai-Ho W, Oppelt P, Ghosh D, Bykowski J, Molinolo A, Pittman E, Estrada MV, Gold K, Daniels G, Lippman SM, Natsuhara A, Messer K, Cohen EEW. PMID: 33989559.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCTClinical Trials
    18. Progesterone promotes immunomodulation and tumor development in the murine mammary gland. J Immunother Cancer. 2021 05; 9(5). Werner LR, Gibson KA, Goodman ML, Helm DE, Walter KR, Holloran SM, Trinca GM, Hastings RC, Yang HH, Hu Y, Wei J, Lei G, Yang XY, Madan R, Molinolo AA, Markiewicz MA, Chalise P, Axelrod ML, Balko JM, Hunter KW, Hartman ZC, Lange CA, Hagan CR. PMID: 33958486; PMCID: PMC8103939.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    19. Potential Use of College of American Pathologists Accredited Biorepositories to Bridge Unmet Need for Medical Refrigeration Using Ultralow Temperature Storage for COVID-19 Vaccine or Drug Storage. Biopreserv Biobank. 2021 06; 19(3):154-155. Kaushal S, Molinolo A. PMID: 33926206; PMCID: PMC8217586.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    20. Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer. Nat Commun. 2021 04 22; 12(1):2383. Wang Z, Goto Y, Allevato MM, Wu VH, Saddawi-Konefka R, Gilardi M, Alvarado D, Yung BS, O'Farrell A, Molinolo AA, Duvvuri U, Grandis JR, Califano JA, Cohen EEW, Gutkind JS. PMID: 33888713; PMCID: PMC8062674.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    21. The molecular underpinning of geminin-overexpressing triple-negative breast cancer cells homing specifically to lungs. Cancer Gene Ther. 2022 03; 29(3-4):304-325. Sami E, Bogan D, Molinolo A, Koziol J, ElShamy WM. PMID: 33723406.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    22. Cancer-associated fibroblast secretion of PDGFC promotes gastrointestinal stromal tumor growth and metastasis. Oncogene. 2021 03; 40(11):1957-1973. Yoon H, Tang CM, Banerjee S, Yebra M, Noh S, Burgoyne AM, Torre J, Siena M, Liu M, Klug LR, Choi YY, Hosseini M, Delgado AL, Wang Z, French RP, Lowy A, DeMatteo RP, Heinrich MC, Molinolo AA, Gutkind JS, Harismendy O, Sicklick JK. PMID: 33603171; PMCID: PMC7979540.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    23. The anti-tumour activity of DNA methylation inhibitor 5-aza-2'-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress. Cancer Lett. 2021 03 31; 501:172-186. Gleneadie HJ, Baker AH, Batis N, Bryant J, Jiang Y, Clokie SJH, Mehanna H, Garcia P, Gendoo DMA, Roberts S, Burley M, Molinolo AA, Gutkind JS, Scheven BA, Cooper PR, Parish JL, Khanim FL, Wiench M. PMID: 33359448; PMCID: PMC7845757.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    24. Detecting cancer metastasis and accompanying protein biomarkers at single cell levels using a 3D-printed microfluidic immunoarray. Biosens Bioelectron. 2021 Jan 01; 171:112681. Sharafeldin M, Chen T, Ozkaya GU, Choudhary D, Molinolo AA, Gutkind JS, Rusling JF. PMID: 33096435; PMCID: PMC7666000.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    25. Determining the molecular landscape and impact on prognosis in HPV-associated head and neck cancer. Cancers Head Neck. 2020; 5:11. Khanna S, Palackdharry S, Roof L, Wicker CA, Mark J, Zhu Z, Jandorav R, Molinolo A, Takiar V, Wise-Draper TM. PMID: 32944296; PMCID: PMC7487583.
      View in: PubMed   Mentions: 6  
    26. HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers. Oncogene. 2020 10; 39(40):6327-6339. Ren S, Gaykalova DA, Guo T, Favorov AV, Fertig EJ, Tamayo P, Callejas-Valera JL, Allevato M, Gilardi M, Santos J, Fukusumi T, Sakai A, Ando M, Sadat S, Liu C, Xu G, Fisch KM, Wang Z, Molinolo AA, Gutkind JS, Ideker T, Koch WM, Califano JA. PMID: 32848210; PMCID: PMC7529583.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    27. Suppressing neutrophil-dependent angiogenesis abrogates resistance to anti-VEGF antibody in a genetic model of colorectal cancer. Proc Natl Acad Sci U S A. 2020 09 01; 117(35):21598-21608. Itatani Y, Yamamoto T, Zhong C, Molinolo AA, Ruppel J, Hegde P, Taketo MM, Ferrara N. PMID: 32817421; PMCID: PMC7474657.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    28. Tipifarnib as a Precision Therapy for HRAS-Mutant Head and Neck Squamous Cell Carcinomas. Mol Cancer Ther. 2020 09; 19(9):1784-1796. Gilardi M, Wang Z, Proietto M, Chillà A, Calleja-Valera JL, Goto Y, Vanoni M, Janes MR, Mikulski Z, Gualberto A, Molinolo AA, Ferrara N, Gutkind JS, Burrows F. PMID: 32727882; PMCID: PMC7484242.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    29. Aberrant expression of CPSF1 promotes head and neck squamous cell carcinoma via regulating alternative splicing. PLoS One. 2020; 15(5):e0233380. Sakai A, Ando M, Fukusumi T, Ren S, Liu C, Qualliotine J, Haft S, Sadat S, Saito Y, Guo TW, Xu G, Sasik R, Fisch KM, Gutkind JS, Fertig EJ, Molinolo AA, Califano JA. PMID: 32437477; PMCID: PMC7241804.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    30. Cryopreservation of Viable Human Tissues: Renewable Resource for Viable Tissue, Cell Lines, and Organoid Development. Biopreserv Biobank. 2020 Jun; 18(3):222-227. He A, Powell S, Kyle M, Rose M, Masmila E, Estrada V, Sicklick JK, Molinolo A, Kaushal S. PMID: 32302515; PMCID: PMC7310214.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    31. Age-related differences in breast cancer mortality according to race/ethnicity, insurance, and socioeconomic status. BMC Cancer. 2020 Mar 17; 20(1):228. San Miguel Y, Gomez SL, Murphy JD, Schwab RB, McDaniels-Davidson C, Canchola AJ, Molinolo AA, Nodora JN, Martinez ME. PMID: 32178638; PMCID: PMC7076958.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    32. Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4. Nat Commun. 2019 12 05; 10(1):5546. Wang Z, Wu VH, Allevato MM, Gilardi M, He Y, Luis Callejas-Valera J, Vitale-Cross L, Martin D, Amornphimoltham P, Mcdermott J, Yung BS, Goto Y, Molinolo AA, Sharabi AB, Cohen EEW, Chen Q, Lyons JG, Alexandrov LB, Gutkind JS. PMID: 31804466; PMCID: PMC6895221.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    33. Phase 1 dose-finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer. Cancer. 2020 01 15; 126(2):354-362. Gulati S, Desai J, Palackdharry SM, Morris JC, Zhu Z, Jandarov R, Riaz MK, Takiar V, Mierzwa M, Gutkind JS, Molinolo A, Desai PB, Sadraei NH, Wise-Draper TM. PMID: 31626727; PMCID: PMC10402880.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCTClinical Trials
    34. FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy. Elife. 2019 09 03; 8. Diaz Osterman CJ, Ozmadenci D, Kleinschmidt EG, Taylor KN, Barrie AM, Jiang S, Bean LM, Sulzmaier FJ, Jean C, Tancioni I, Anderson K, Uryu S, Cordasco EA, Li J, Chen XL, Fu G, Ojalill M, Rappu P, Heino J, Mark AM, Xu G, Fisch KM, Kolev VN, Weaver DT, Pachter JA, Gyorffy B, McHale MT, Connolly DC, Molinolo A, Stupack DG, Schlaepfer DD. PMID: 31478830; PMCID: PMC6721800.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    35. Real-Time Temperature Mapping in Ultra-Low Freezers as a Standard Quality Assessment. Biopreserv Biobank. 2019 Apr; 17(2):139-142. Powell S, Molinolo A, Masmila E, Kaushal S. PMID: 30912671; PMCID: PMC6479232.
      View in: PubMed   Mentions: 1     Fields:    
    36. 4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer. Cancer Res. 2019 04 01; 79(7):1438-1450. Wang Z, Feng X, Molinolo AA, Martin D, Vitale-Cross L, Nohata N, Ando M, Wahba A, Amornphimoltham P, Wu X, Gilardi M, Allevato M, Wu V, Steffen DJ, Tofilon P, Sonenberg N, Califano J, Chen Q, Lippman SM, Gutkind JS. PMID: 30894372; PMCID: PMC6445709.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    37. Activation of RANK/RANKL/OPG Pathway Is Involved in the Pathophysiology of Fibrous Dysplasia and Associated With Disease Burden. J Bone Miner Res. 2019 02; 34(2):290-294. de Castro LF, Burke AB, Wang HD, Tsai J, Florenzano P, Pan KS, Bhattacharyya N, Boyce AM, Gafni RI, Molinolo AA, Robey PG, Collins MT. PMID: 30496606; PMCID: PMC6983320.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCellsCTClinical Trials
    38. Inhibition of mTOR Signaling and Clinical Activity of Rapamycin in Head and Neck Cancer in a Window of Opportunity Trial. Clin Cancer Res. 2019 02 15; 25(4):1156-1164. Day TA, Shirai K, O'Brien PE, Matheus MG, Godwin K, Sood AJ, Kompelli A, Vick JA, Martin D, Vitale-Cross L, Callejas-Varela JL, Wang Z, Wu X, Harismendy O, Molinolo AA, Lippman SM, Van Waes C, Szabo E, Gutkind JS. PMID: 30420444; PMCID: PMC6377824.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    39. Breast Cancer Mortality in Older and Younger Patients in California. Cancer Epidemiol Biomarkers Prev. 2019 02; 28(2):303-310. Tao L, Schwab RB, San Miguel Y, Gomez SL, Canchola AJ, Gago-Dominguez M, Komenaka IK, Murphy JD, Molinolo AA, Martinez ME. PMID: 30333222; PMCID: PMC6363871.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    40. Transcriptional signature primes human oral mucosa for rapid wound healing. Sci Transl Med. 2018 07 25; 10(451). Iglesias-Bartolome R, Uchiyama A, Molinolo AA, Abusleme L, Brooks SR, Callejas-Valera JL, Edwards D, Doci C, Asselin-Labat ML, Onaitis MW, Moutsopoulos NM, Gutkind JS, Morasso MI. PMID: 30045979; PMCID: PMC6598699.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    41. Biological and clinical impact of imbalanced progesterone receptor isoform ratios in breast cancer. Endocr Relat Cancer. 2018 Jul 10. Lamb CA, Fabris VT, Jacobsen B, Molinolo AA, Lanari C. PMID: 29991638.
      View in: PubMed   Mentions: 11     Fields:    
    42. Assembly and activation of the Hippo signalome by FAT1 tumor suppressor. Nat Commun. 2018 07 09; 9(1):2372. Martin D, Degese MS, Vitale-Cross L, Iglesias-Bartolome R, Valera JLC, Wang Z, Feng X, Yeerna H, Vadmal V, Moroishi T, Thorne RF, Zaida M, Siegele B, Cheong SC, Molinolo AA, Samuels Y, Tamayo P, Guan KL, Lippman SM, Lyons JG, Gutkind JS. PMID: 29985391; PMCID: PMC6037762.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    43. Increased High Molecular Weight FGF2 in Endocrine-Resistant Breast Cancer. Horm Cancer. 2018 10; 9(5):338-348. Sahores A, Figueroa V, May M, Liguori M, Rubstein A, Fuentes C, Jacobsen BM, Elía A, Rojas P, Sequeira GR, Álvarez MM, González P, Gass H, Hewitt S, Molinolo A, Lanari C, Lamb CA. PMID: 29956066; PMCID: PMC8054767.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    44. Positive Surgical Margins in the 10 Most Common Solid Cancers. Sci Rep. 2018 04 09; 8(1):5686. Orosco RK, Tapia VJ, Califano JA, Clary B, Cohen EEW, Kane C, Lippman SM, Messer K, Molinolo A, Murphy JD, Pang J, Sacco A, Tringale KR, Wallace A, Nguyen QT. PMID: 29632347; PMCID: PMC5890246.
      View in: PubMed   Mentions: 70     Fields:    Translation:Humans
    45. Tumor-induced osteomalacia in association with PTEN-negative Cowden syndrome. Osteoporos Int. 2018 04; 29(4):993-997. Berglund JA, Gafni RI, Wodajo F, Cowen EW, El-Maouche D, Chang R, Chen CC, Guthrie LC, Molinolo AA, Collins MT. PMID: 29380000; PMCID: PMC7983154.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    46. Expression of an active Gαs mutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance. Proc Natl Acad Sci U S A. 2018 01 16; 115(3):E428-E437. Zhao X, Deng P, Iglesias-Bartolome R, Amornphimoltham P, Steffen DJ, Jin Y, Molinolo AA, de Castro LF, Ovejero D, Yuan Q, Chen Q, Han X, Bai D, Taylor SS, Yang Y, Collins MT, Gutkind JS. PMID: 29282319; PMCID: PMC5776975.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    47. Isoform specificity of progesterone receptor antibodies. J Pathol Clin Res. 2017 Oct; 3(4):227-233. Fabris V, Abascal MF, Giulianelli S, May M, Sequeira GR, Jacobsen B, Lombès M, Han J, Tran L, Molinolo A, Lanari C. PMID: 29085663; PMCID: PMC5653926.
      View in: PubMed   Mentions: 7     Fields:    
    48. Liver damage and senescence increases in patients developing hepatocellular carcinoma. J Gastroenterol Hepatol. 2017 Aug; 32(8):1480-1486. Rey S, Quintavalle C, Burmeister K, Calabrese D, Schlageter M, Quagliata L, Cathomas G, Diebold J, Molinolo A, Heim MH, Terracciano LM, Matter MS. PMID: 28052383.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    49. Visualization of macrophage recruitment in head and neck carcinoma model using fluorine-19 magnetic resonance imaging. Magn Reson Med. 2018 04; 79(4):1972-1980. Khurana A, Chapelin F, Xu H, Acevedo JR, Molinolo A, Nguyen Q, Ahrens ET. PMID: 28748562; PMCID: PMC5807236.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    50. Progesterone Receptor Isoform Ratio: A Breast Cancer Prognostic and Predictive Factor for Antiprogestin Responsiveness. J Natl Cancer Inst. 2017 07 01; 109(7). Rojas PA, May M, Sequeira GR, Elia A, Alvarez M, Martínez P, Gonzalez P, Hewitt S, He X, Perou CM, Molinolo A, Gibbons L, Abba MC, Gass H, Lanari C. PMID: 28376177; PMCID: PMC6059180.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    51. Early detection of squamous cell carcinoma in carcinogen induced oral cancer rodent model by ratiometric activatable cell penetrating peptides. Oral Oncol. 2017 08; 71:156-162. Hingorani DV, Lemieux AJ, Acevedo JR, Glasgow HL, Kedarisetty S, Whitney MA, Molinolo AA, Tsien RY, Nguyen QT. PMID: 28688684; PMCID: PMC5575898.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    52. Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes. PLoS One. 2017; 12(3):e0173692. Doçi CL, Mikelis CM, Callejas-Valera JL, Hansen KK, Molinolo AA, Inoue A, Offermanns S, Gutkind JS. PMID: 28301547; PMCID: PMC5354386.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    53. Phenotypic and Genotypic Characterization and Treatment of a Cohort With Familial Tumoral Calcinosis/Hyperostosis-Hyperphosphatemia Syndrome. J Bone Miner Res. 2016 10; 31(10):1845-1854. Ramnitz MS, Gourh P, Goldbach-Mansky R, Wodajo F, Ichikawa S, Econs MJ, White KE, Molinolo A, Chen MY, Heller T, Del Rivero J, Seo-Mayer P, Arabshahi B, Jackson MB, Hatab S, McCarthy E, Guthrie LC, Brillante BA, Gafni RI, Collins MT. PMID: 27164190; PMCID: PMC5071128.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCTClinical Trials
    54. mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model. Carcinogenesis. 2016 10; 37(10):1014-25. Callejas-Valera JL, Iglesias-Bartolome R, Amornphimoltham P, Palacios-Garcia J, Martin D, Califano JA, Molinolo AA, Gutkind JS. PMID: 27538837; PMCID: PMC6276901.
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    55. Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies. Oncotarget. 2016 May 10; 7(19):27802-18. Fadlullah MZ, Chiang IK, Dionne KR, Yee PS, Gan CP, Sam KK, Tiong KH, Ng AK, Martin D, Lim KP, Kallarakkal TG, Mustafa WM, Lau SH, Abraham MT, Zain RB, Rahman ZA, Molinolo A, Patel V, Gutkind JS, Tan AC, Cheong SC. PMID: 27050151; PMCID: PMC5053689.
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    56. Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype. Hepatology. 2016 06; 63(6):1888-99. Matter MS, Marquardt JU, Andersen JB, Quintavalle C, Korokhov N, Stauffer JK, Kaji K, Decaens T, Quagliata L, Elloumi F, Hoang T, Molinolo A, Conner EA, Weber A, Heikenwalder M, Factor VM, Thorgeirsson SS. PMID: 26844528; PMCID: PMC4874846.
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    57. A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers. Oncotarget. 2016 Mar 08; 7(10):10696-709. Yamaguchi K, Iglesias-Bartolomé R, Wang Z, Callejas-Valera JL, Amornphimoltham P, Molinolo AA, Cohen EE, Califano JA, Lippman SM, Luo J, Gutkind JS. PMID: 26882569; PMCID: PMC4905432.
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    58. Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells. Oncogene. 2016 07 21; 35(29):3771-80. O'Hayre M, Inoue A, Kufareva I, Wang Z, Mikelis CM, Drummond RA, Avino S, Finkel K, Kalim KW, DiPasquale G, Guo F, Aoki J, Zheng Y, Lionakis MS, Molinolo AA, Gutkind JS. PMID: 26616858; PMCID: PMC4885800.
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    59. Nuclear staining of fgfr-2/stat-5 and runx-2 in mucinous breast cancer. Exp Mol Pathol. 2016 Feb; 100(1):39-44. May M, Mosto J, Vazquez PM, Gonzalez P, Rojas P, Gass H, Lanari C, Molinolo AA. PMID: 26551078.
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    60. A Simple Device to Rapidly Prepare Whole Mounts of the Mouse Intestine. J Vis Exp. 2015 Oct 27; (105):e53042. Yoneda M, Molinolo AA, Ward JM, Kimura S, Goodlad RA. PMID: 26556642; PMCID: PMC4692677.
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    61. Toxicological Studies of 212Pb Intravenously or Intraperitoneally Injected into Mice for a Phase 1 Trial. Pharmaceuticals (Basel). 2015 Jul 24; 8(3):416-34. Milenic DE, Molinolo AA, Solivella MS, Banaga E, Torgue J, Besnainou S, Brechbiel MW, Baidoo KE. PMID: 26213947; PMCID: PMC4588175.
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    62. Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis. Nat Cell Biol. 2015 Jun; 17(6):793-803. Iglesias-Bartolome R, Torres D, Marone R, Feng X, Martin D, Simaan M, Chen M, Weinstein LS, Taylor SS, Molinolo AA, Gutkind JS. PMID: 25961504; PMCID: PMC4449815.
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    63. Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma. Cancer Res. 2015 Jul 15; 75(14):2937-48. Doçi CL, Mikelis CM, Lionakis MS, Molinolo AA, Gutkind JS. PMID: 25952650; PMCID: PMC4538958.
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    64. Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling. Nat Commun. 2015 Apr 15; 6:6776. Zoratti GL, Tanabe LM, Varela FA, Murray AS, Bergum C, Colombo É, Lang JE, Molinolo AA, Leduc R, Marsault E, Boerner J, List K. PMID: 25873032; PMCID: PMC4749267.
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    65. Prevention of tumor growth driven by PIK3CA and HPV oncogenes by targeting mTOR signaling with metformin in oral squamous carcinomas expressing OCT3. Cancer Prev Res (Phila). 2015 Mar; 8(3):197-207. Madera D, Vitale-Cross L, Martin D, Schneider A, Molinolo AA, Gangane N, Carey TE, McHugh JB, Komarck CM, Walline HM, William WN, Seethala RR, Ferris RL, Gutkind JS. PMID: 25681087; PMCID: PMC4355306.
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    66. SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis. FASEB J. 2015 Mar; 29(3):1056-68. Dillenburg-Pilla P, Patel V, Mikelis CM, Zárate-Bladés CR, Doçi CL, Amornphimoltham P, Wang Z, Martin D, Leelahavanichkul K, Dorsam RT, Masedunskas A, Weigert R, Molinolo AA, Gutkind JS. PMID: 25466898; PMCID: PMC4422355.
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    67. A systems genetics approach identifies CXCL14, ITGAX, and LPCAT2 as novel aggressive prostate cancer susceptibility genes. PLoS Genet. 2014 Nov; 10(11):e1004809. Williams KA, Lee M, Hu Y, Andreas J, Patel SJ, Zhang S, Chines P, Elkahloun A, Chandrasekharappa S, Gutkind JS, Molinolo AA, Crawford NP. PMID: 25411967; PMCID: PMC4238980.
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    68. Progestin and antiprogestin responsiveness in breast cancer is driven by the PRA/PRB ratio via AIB1 or SMRT recruitment to the CCND1 and MYC promoters. Int J Cancer. 2015 Jun 01; 136(11):2680-92. Wargon V, Riggio M, Giulianelli S, Sequeira GR, Rojas P, May M, Polo ML, Gorostiaga MA, Jacobsen B, Molinolo A, Novaro V, Lanari C. PMID: 25363551; PMCID: PMC4361264.
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    69. Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis. Oncotarget. 2014 Oct 30; 5(20):9626-40. Gan CP, Patel V, Mikelis CM, Zain RB, Molinolo AA, Abraham MT, Teo SH, Abdul Rahman ZA, Gutkind JS, Cheong SC. PMID: 25275299; PMCID: PMC4259425.
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    70. The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies. Oncotarget. 2014 Oct 15; 5(19):8906-23. Martin D, Abba MC, Molinolo AA, Vitale-Cross L, Wang Z, Zaida M, Delic NC, Samuels Y, Lyons JG, Gutkind JS. PMID: 25275298; PMCID: PMC4253406.
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    71. Cholecystokinin receptor antagonist halts progression of pancreatic cancer precursor lesions and fibrosis in mice. Pancreas. 2014 Oct; 43(7):1050-9. Smith JP, Cooper TK, McGovern CO, Gilius EL, Zhong Q, Liao J, Molinolo AA, Gutkind JS, Matters GL. PMID: 25058882; PMCID: PMC4161619.
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    72. mTOR co-targeting in cetuximab resistance in head and neck cancers harboring PIK3CA and RAS mutations. J Natl Cancer Inst. 2014 Sep; 106(9). Wang Z, Martin D, Molinolo AA, Patel V, Iglesias-Bartolome R, Degese MS, Vitale-Cross L, Chen Q, Gutkind JS. PMID: 25099740; PMCID: PMC4133928.
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    73. Immune consequences of decreasing tumor vasculature with antiangiogenic tyrosine kinase inhibitors in combination with therapeutic vaccines. Cancer Immunol Res. 2014 Nov; 2(11):1090-102. Farsaci B, Donahue RN, Coplin MA, Grenga I, Lepone LM, Molinolo AA, Hodge JW. PMID: 25092771; PMCID: PMC4221465.
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    74. TMPRSS13 deficiency impairs stratum corneum formation and epidermal barrier acquisition. Biochem J. 2014 Aug 01; 461(3):487-95. Madsen DH, Szabo R, Molinolo AA, Bugge TH. PMID: 24832573; PMCID: PMC4625982.
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    75. Comparative toxicity and efficacy of engineered anthrax lethal toxin variants with broad anti-tumor activities. Toxicol Appl Pharmacol. 2014 Sep 01; 279(2):220-9. Peters DE, Hoover B, Cloud LG, Liu S, Molinolo AA, Leppla SH, Bugge TH. PMID: 24971906; PMCID: PMC4137396.
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    76. The effectiveness of nano chemotherapeutic particles combined with mifepristone depends on the PR isoform ratio in preclinical models of breast cancer. Oncotarget. 2014 May 30; 5(10):3246-60. Sequeira G, Vanzulli SI, Rojas P, Lamb C, Colombo L, May M, Molinolo A, Lanari C. PMID: 24912774; PMCID: PMC4102807.
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    77. Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. Cancer Cell. 2014 Jun 16; 25(6):831-45. Feng X, Degese MS, Iglesias-Bartolome R, Vaque JP, Molinolo AA, Rodrigues M, Zaidi MR, Ksander BR, Merlino G, Sodhi A, Chen Q, Gutkind JS. PMID: 24882515; PMCID: PMC4074519.
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    78. Effects of denosumab treatment and discontinuation on human growth plates. J Clin Endocrinol Metab. 2014 Mar; 99(3):891-7. Wang HD, Boyce AM, Tsai JY, Gafni RI, Farley FA, Kasa-Vubu JZ, Molinolo AA, Collins MT. PMID: 24423331; PMCID: PMC3942242.
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    79. Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma. Pigment Cell Melanoma Res. 2014 Jan; 27(1):37-47. Simpson RM, Bastian BC, Michael HT, Webster JD, Prasad ML, Conway CM, Prieto VM, Gary JM, Goldschmidt MH, Esplin DG, Smedley RC, Piris A, Meuten DJ, Kiupel M, Lee CC, Ward JM, Dwyer JE, Davis BJ, Anver MR, Molinolo AA, Hoover SB, Rodriguez-Canales J, Hewitt SM. PMID: 24128326; PMCID: PMC4066658.
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    80. A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesis. Mol Oncol. 2014 Feb; 8(1):105-18. Leelahavanichkul K, Amornphimoltham P, Molinolo AA, Basile JR, Koontongkaew S, Gutkind JS. PMID: 24216180; PMCID: PMC3946852.
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    81. WISP1/CCN4: a potential target for inhibiting prostate cancer growth and spread to bone. PLoS One. 2013; 8(8):e71709. Ono M, Inkson CA, Sonn R, Kilts TM, de Castro LF, Maeda A, Fisher LW, Robey PG, Berendsen AD, Li L, McCartney-Francis N, Brown AC, Crawford NP, Molinolo A, Jain A, Fedarko NS, Young MF. PMID: 23977121; PMCID: PMC3743748.
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    82. Improved clearance during treatment of HPV-positive head and neck cancer through mTOR inhibition. Neoplasia. 2013 Jun; 15(6):620-30. Coppock JD, Wieking BG, Molinolo AA, Gutkind JS, Miskimins WK, Lee JH. PMID: 23730210; PMCID: PMC3664994.
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    83. Accumulation of dephosphorylated 4EBP after mTOR inhibition with rapamycin is sufficient to disrupt paracrine transformation by the KSHV vGPCR oncogene. Oncogene. 2014 May 01; 33(18):2405-12. Martin D, Nguyen Q, Molinolo A, Gutkind JS. PMID: 23708663.
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    84. Novel, low cost, highly effective, handmade steroid pellets for experimental studies. PLoS One. 2013; 8(5):e64049. Sahores A, Luque GM, Wargon V, May M, Molinolo A, Becu-Villalobos D, Lanari C, Lamb CA. PMID: 23691144; PMCID: PMC3655057.
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    85. PTEN deficiency contributes to the development and progression of head and neck cancer. Neoplasia. 2013 May; 15(5):461-71. Squarize CH, Castilho RM, Abrahao AC, Molinolo A, Lingen MW, Gutkind JS. PMID: 23633918; PMCID: PMC3638349.
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    86. Germline genetic variation modulates tumor progression and metastasis in a mouse model of neuroendocrine prostate carcinoma. PLoS One. 2013; 8(4):e61848. Patel SJ, Molinolo AA, Gutkind S, Crawford NP. PMID: 23620793; PMCID: PMC3631138.
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    87. Rab25 regulates invasion and metastasis in head and neck cancer. Clin Cancer Res. 2013 Mar 15; 19(6):1375-88. Amornphimoltham P, Rechache K, Thompson J, Masedunskas A, Leelahavanichkul K, Patel V, Molinolo A, Gutkind JS, Weigert R. PMID: 23340300; PMCID: PMC3602237.
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    88. Targeting progesterone receptors in breast cancer. Vitam Horm. 2013; 93:161-84. Giulianelli S, Molinolo A, Lanari C. PMID: 23810006.
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    89. DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays. Oral Oncol. 2013 Feb; 49(2):93-101. Patel V, Martin D, Malhotra R, Marsh CA, Doçi CL, Veenstra TD, Nathan CA, Sinha UK, Singh B, Molinolo AA, Rusling JF, Gutkind JS. PMID: 23010602; PMCID: PMC3546158.
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    90. mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis. Cell Stem Cell. 2012 Sep 07; 11(3):401-14. Iglesias-Bartolome R, Patel V, Cotrim A, Leelahavanichkul K, Molinolo AA, Mitchell JB, Gutkind JS. PMID: 22958932; PMCID: PMC3477550.
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    91. Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbal's, preputial, and clitoral glands. Toxicol Pathol. 2012 Aug; 40(6 Suppl):7S-39S. Rudmann D, Cardiff R, Chouinard L, Goodman D, Küttler K, Marxfeld H, Molinolo A, Treumann S, Yoshizawa K, INHAND Mammary, Zymbal's, Preputial, and Clitoral Gland Organ Working Group. PMID: 22949413.
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    92. Activation of the mTOR pathway in primary medullary thyroid carcinoma and lymph node metastases. Clin Cancer Res. 2012 Jul 01; 18(13):3532-40. Tamburrino A, Molinolo AA, Salerno P, Chernock RD, Raffeld M, Xi L, Gutkind JS, Moley JF, Wells SA, Santoro M. PMID: 22753663.
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    93. Denosumab treatment for fibrous dysplasia. J Bone Miner Res. 2012 Jul; 27(7):1462-70. Boyce AM, Chong WH, Yao J, Gafni RI, Kelly MH, Chamberlain CE, Bassim C, Cherman N, Ellsworth M, Kasa-Vubu JZ, Farley FA, Molinolo AA, Bhattacharyya N, Collins MT. PMID: 22431375; PMCID: PMC3377825.
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    94. Nuclear localization of heme oxygenase-1 is associated with tumor progression of head and neck squamous cell carcinomas. Exp Mol Pathol. 2012 Oct; 93(2):237-45. Gandini NA, Fermento ME, Salomón DG, Blasco J, Patel V, Gutkind JS, Molinolo AA, Facchinetti MM, Curino AC. PMID: 22580187.
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    95. Capillary morphogenesis protein-2 is required for mouse parturition by maintaining uterine collagen homeostasis. Biochem Biophys Res Commun. 2012 Jun 08; 422(3):393-7. Peters DE, Zhang Y, Molinolo AA, Miller-Randolph S, Szabo R, Bugge TH, Leppla SH, Liu S. PMID: 22575514; PMCID: PMC3376708.
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    96. Antiprogestins in breast cancer treatment: are we ready? Endocr Relat Cancer. 2012 Jun; 19(3):R35-50. Lanari C, Wargon V, Rojas P, Molinolo AA. PMID: 22351709.
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    97. Metformin prevents the development of oral squamous cell carcinomas from carcinogen-induced premalignant lesions. Cancer Prev Res (Phila). 2012 Apr; 5(4):562-73. Vitale-Cross L, Molinolo AA, Martin D, Younis RH, Maruyama T, Patel V, Chen W, Schneider A, Gutkind JS. PMID: 22467081; PMCID: PMC3429367.
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    98. Expression of heme oxygenase-1 in non-small cell lung cancer (NSCLC) and its correlation with clinical data. Lung Cancer. 2012 Jul; 77(1):168-75. Degese MS, Mendizabal JE, Gandini NA, Gutkind JS, Molinolo A, Hewitt SM, Curino AC, Coso OA, Facchinetti MM. PMID: 22418244; PMCID: PMC8381257.
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    99. mTOR as a molecular target in HPV-associated oral and cervical squamous carcinomas. Clin Cancer Res. 2012 May 01; 18(9):2558-68. Molinolo AA, Marsh C, El Dinali M, Gangane N, Jennison K, Hewitt S, Patel V, Seiwert TY, Gutkind JS. PMID: 22409888; PMCID: PMC3443560.
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    100. Estrogen receptor alpha mediates progestin-induced mammary tumor growth by interacting with progesterone receptors at the cyclin D1/MYC promoters. Cancer Res. 2012 May 01; 72(9):2416-27. Giulianelli S, Vaqué JP, Soldati R, Wargon V, Vanzulli SI, Martins R, Zeitlin E, Molinolo AA, Helguero LA, Lamb CA, Gutkind JS, Lanari C. PMID: 22396492.
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    101. Future directions and treatment strategies for head and neck squamous cell carcinomas. Transl Res. 2012 Sep; 160(3):167-77. Wise-Draper TM, Draper DJ, Gutkind JS, Molinolo AA, Wikenheiser-Brokamp KA, Wells SI. PMID: 22683420; PMCID: PMC3423575.
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    102. [The role of estrogen receptor alpha in breast cancer cell proliferation mediated by progestins]. Medicina (B Aires). 2012; 72(4):315-20. Giulianelli S, Vaqué JP, Wargon V, Soldati R, Vanzulli SI, Martins R, Zeitlin E, Helguero L, Lamb C, Molinolo AA, Gutkind JS, Lanari C. PMID: 22892083.
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    103. Suppression of Tumorigenicity-14, encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis. Oncogene. 2012 Aug 09; 31(32):3679-95. Kosa P, Szabo R, Molinolo AA, Bugge TH. PMID: 22139080; PMCID: PMC3299858.
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    104. Associated expressions of FGFR-2 and FGFR-3: from mouse mammary gland physiology to human breast cancer. Breast Cancer Res Treat. 2012 Jun; 133(3):997-1008. Cerliani JP, Vanzulli SI, Piñero CP, Bottino MC, Sahores A, Nuñez M, Varchetta R, Martins R, Zeitlin E, Hewitt SM, Molinolo AA, Lanari C, Lamb CA. PMID: 22124578; PMCID: PMC7511987.
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    105. Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation. Oncogene. 2012 Jul 12; 31(28):3322-32. Bian Y, Hall B, Sun ZJ, Molinolo A, Chen W, Gutkind JS, Waes CV, Kulkarni AB. PMID: 22037217; PMCID: PMC3270146.
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    106. Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer. Cancer Res. 2011 Nov 15; 71(22):7103-12. Patel V, Marsh CA, Dorsam RT, Mikelis CM, Masedunskas A, Amornphimoltham P, Nathan CA, Nathan CA, Singh B, Weigert R, Molinolo AA, Gutkind JS. PMID: 21975930; PMCID: PMC3443559.
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    107. Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma. Nat Genet. 2011 Sep 25; 43(11):1119-26. Prickett TD, Wei X, Cardenas-Navia I, Teer JK, Lin JC, Walia V, Gartner J, Jiang J, Cherukuri PF, Molinolo A, Davies MA, Gershenwald JE, Stemke-Hale K, Rosenberg SA, Margulies EH, Samuels Y. PMID: 21946352; PMCID: PMC3376644.
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    108. A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells. Sci Signal. 2011 Sep 20; 4(191):ra60. Yagi H, Tan W, Dillenburg-Pilla P, Armando S, Amornphimoltham P, Simaan M, Weigert R, Molinolo AA, Bouvier M, Gutkind JS. PMID: 21934106; PMCID: PMC3429372.
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    109. Expression and genetic loss of function analysis of the HAT/DESC cluster proteases TMPRSS11A and HAT. PLoS One. 2011; 6(8):e23261. Sales KU, Hobson JP, Wagenaar-Miller R, Szabo R, Rasmussen AL, Bey A, Shah MF, Molinolo AA, Bugge TH. PMID: 21853097; PMCID: PMC3154331.
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    110. PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis. Cancer Cell. 2011 Jun 14; 19(6):805-13. Martin D, Galisteo R, Molinolo AA, Wetzker R, Hirsch E, Gutkind JS. PMID: 21665152; PMCID: PMC3170773.
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    111. Tumor-induced osteomalacia. Endocr Relat Cancer. 2011 Jun; 18(3):R53-77. Chong WH, Molinolo AA, Chen CC, Collins MT. PMID: 21490240; PMCID: PMC3433741.
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    112. Efficient targeting of head and neck squamous cell carcinoma by systemic administration of a dual uPA and MMP-activated engineered anthrax toxin. PLoS One. 2011; 6(5):e20532. Schafer JM, Peters DE, Morley T, Liu S, Molinolo AA, Leppla SH, Bugge TH. PMID: 21655226; PMCID: PMC3105081.
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    113. c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase. Oncogene. 2011 Apr 28; 30(17):2003-16. Szabo R, Rasmussen AL, Moyer AB, Kosa P, Schafer JM, Molinolo AA, Gutkind JS, Bugge TH. PMID: 21217780; PMCID: PMC3084339.
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    114. Cellular systems for studying human oral squamous cell carcinomas. Adv Exp Med Biol. 2011; 720:27-38. Patel V, Iglesias-Bartolome R, Siegele B, Marsh CA, Leelahavanichkul K, Molinolo AA, Gutkind JS. PMID: 21901616.
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    115. Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice. Nanomedicine (Lond). 2010 Dec; 5(10):1535-46. Bhirde AA, Patel S, Sousa AA, Patel V, Molinolo AA, Ji Y, Leapman RD, Gutkind JS, Rusling JF. PMID: 21143032; PMCID: PMC3175610.
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    116. A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation. Oral Oncol. 2010 Dec; 46(12):880-7. Abrahao AC, Castilho RM, Squarize CH, Molinolo AA, dos Santos-Pinto D, Gutkind JS. PMID: 20951077; PMCID: PMC2991505.
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    117. Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma. Mol Cancer Res. 2010 Nov; 8(11):1513-25. Wei X, Prickett TD, Viloria CG, Molinolo A, Lin JC, Cardenas-Navia I, Cruz P, NISC Comparative Sequencing Program, Rosenberg SA, Davies MA, Gershenwald JE, López-Otín C, Samuels Y. PMID: 21047771; PMCID: PMC3058631.
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    118. MPA-induced gene expression and stromal and parenchymal gene expression profiles in luminal murine mammary carcinomas with different hormonal requirements. Breast Cancer Res Treat. 2011 Aug; 129(1):49-67. Giulianelli S, Herschkowitz JI, Patel V, Lamb CA, Gutkind JS, Molinolo A, Perou CM, Lanari C. PMID: 20890655.
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    119. Viral G protein-coupled receptor up-regulates Angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi's sarcoma. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14363-8. Ma T, Jham BC, Hu J, Friedman ER, Basile JR, Molinolo A, Sodhi A, Montaner S. PMID: 20660728; PMCID: PMC2922606.
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    120. Inoculated mammary carcinoma-associated fibroblasts: contribution to hormone independent tumor growth. BMC Cancer. 2010 Jun 16; 10:293. Fabris VT, Sahores A, Vanzulli SI, Colombo L, Molinolo AA, Lanari C, Lamb CA. PMID: 20553594; PMCID: PMC2894798.
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    121. Classical membrane progesterone receptors in murine mammary carcinomas: agonistic effects of progestins and RU-486 mediating rapid non-genomic effects. Breast Cancer Res Treat. 2011 Apr; 126(3):621-36. Bottino MC, Cerliani JP, Rojas P, Giulianelli S, Soldati R, Mondillo C, Gorostiaga MA, Pignataro OP, Calvo JC, Gutkind JS, Molinolo AA, Lüthy IA, Lanari C. PMID: 20535544.
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    122. Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation. Blood. 2010 Sep 02; 116(9):1593-603. Connolly BM, Choi EY, Gårdsvoll H, Bey AL, Currie BM, Chavakis T, Liu S, Molinolo A, Ploug M, Leppla SH, Bugge TH. PMID: 20466854; PMCID: PMC2938846.
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    123. Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes. Cancer Res. 2010 Jan 15; 70(2):741-51. Novosyadlyy R, Lann DE, Vijayakumar A, Rowzee A, Lazzarino DA, Fierz Y, Carboni JM, Gottardis MM, Pennisi PA, Molinolo AA, Kurshan N, Mejia W, Santopietro S, Yakar S, Wood TL, LeRoith D. PMID: 20068149; PMCID: PMC2946167.
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    124. Mifepristone inhibits MPA-and FGF2-induced mammary tumor growth but not FGF2-induced mammary hyperplasia. Medicina (B Aires). 2010; 70(6):529-32. Cerliani JP, Giulianelli S, Sahores A, Wargon V, Gongora A, Baldi A, Molinolo A, Lamb CE, Lanari C. PMID: 21163742.
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    125. Inhibition of mammary tumor growth by estrogens: is there a specific role for estrogen receptors alpha and beta? Breast Cancer Res Treat. 2010 Oct; 123(3):709-24. Soldati R, Wargon V, Cerliani JP, Giulianelli S, Vanzulli SI, Gorostiaga MA, Bolado J, do Campo P, Molinolo A, Vollmer G, Lanari C. PMID: 20012353.
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    126. Expression of plasmid DNA in the salivary gland epithelium: novel approaches to study dynamic cellular processes in live animals. Am J Physiol Cell Physiol. 2009 Dec; 297(6):C1347-57. Sramkova M, Masedunskas A, Parente L, Molinolo A, Weigert R. PMID: 19794147; PMCID: PMC2793061.
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    127. Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway. Am J Pathol. 2009 Oct; 175(4):1453-63. List K, Kosa P, Szabo R, Bey AL, Wang CB, Molinolo A, Bugge TH. PMID: 19717635; PMCID: PMC2751542.
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    128. Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway. Cancer Res. 2009 Jul 15; 69(14):5918-26. Bian Y, Terse A, Du J, Hall B, Molinolo A, Zhang P, Chen W, Flanders KC, Gutkind JS, Wakefield LM, Kulkarni AB. PMID: 19584284; PMCID: PMC2758611.
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    129. Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model. Cancer Res. 2009 May 15; 69(10):4159-66. Raimondi AR, Molinolo A, Gutkind JS. PMID: 19435901.
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    130. Chemical carcinogenesis models for evaluating molecular-targeted prevention and treatment of oral cancer. Cancer Prev Res (Phila). 2009 May; 2(5):419-22. Vitale-Cross L, Czerninski R, Amornphimoltham P, Patel V, Molinolo AA, Gutkind JS. PMID: 19401522.
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    131. Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma. Nat Genet. 2009 May; 41(5):518-20. Palavalli LH, Prickett TD, Wunderlich JR, Wei X, Burrell AS, Porter-Gill P, Davis S, Wang C, Cronin JC, Agrawal NS, Lin JC, Westbroek W, Hoogstraten-Miller S, Molinolo AA, Fetsch P, Filie AC, O'Connell MP, Banister CE, Howard JD, Buckhaults P, Weeraratna AT, Brody LC, Rosenberg SA, Samuels Y. PMID: 19330028; PMCID: PMC2748394.
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    132. The MPA mouse breast cancer model: evidence for a role of progesterone receptors in breast cancer. Endocr Relat Cancer. 2009 Jun; 16(2):333-50. Lanari C, Lamb CA, Fabris VT, Helguero LA, Soldati R, Bottino MC, Giulianelli S, Cerliani JP, Wargon V, Molinolo A. PMID: 19190078.
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    133. Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model. Cancer Prev Res (Phila). 2009 Jan; 2(1):27-36. Czerninski R, Amornphimoltham P, Patel V, Molinolo AA, Gutkind JS. PMID: 19139015.
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    134. Inhibition of Mammalian target of rapamycin by rapamycin causes the regression of carcinogen-induced skin tumor lesions. Clin Cancer Res. 2008 Dec 15; 14(24):8094-101. Amornphimoltham P, Leelahavanichkul K, Molinolo A, Patel V, Gutkind JS. PMID: 19073969; PMCID: PMC3407681.
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    135. Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis. Int J Cancer. 2008 Dec 01; 123(11):2518-31. Giulianelli S, Cerliani JP, Lamb CA, Fabris VT, Bottino MC, Gorostiaga MA, Novaro V, Góngora A, Baldi A, Molinolo A, Lanari C. PMID: 18767044.
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    136. Dysregulated molecular networks in head and neck carcinogenesis. Oral Oncol. 2009 Apr-May; 45(4-5):324-34. Molinolo AA, Amornphimoltham P, Squarize CH, Castilho RM, Patel V, Gutkind JS. PMID: 18805044; PMCID: PMC2743485.
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    137. Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity. J Biol Chem. 2008 Oct 24; 283(43):29495-504. Szabo R, Hobson JP, List K, Molinolo A, Lin CY, Bugge TH. PMID: 18713750; PMCID: PMC2570866.
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    138. Reversal of antiprogestin resistance and progesterone receptor isoform ratio in acquired resistant mammary carcinomas. Breast Cancer Res Treat. 2009 Aug; 116(3):449-60. Wargon V, Helguero LA, Bolado J, Rojas P, Novaro V, Molinolo A, Lanari C. PMID: 18677559.
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    139. RCAS/SCL-TVA animal model allows targeted delivery of polyoma middle T oncogene to vascular endothelial progenitors in vivo and results in hemangioma development. Clin Cancer Res. 2008 Jun 15; 14(12):3948-55. Sausville J, Molinolo AA, Cheng X, Frampton J, Takebe N, Gutkind JS, Feldman RA. PMID: 18559617.
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    140. Conditional deletion of cyclin-dependent kinase 5 in primary sensory neurons leads to atypical skin lesions. Cell Cycle. 2008 Mar 15; 7(6):750-3. Saikkonen B, Pareek TK, Agarwal N, Molinolo A, Kriete M, Kulkarni AB. PMID: 18239462; PMCID: PMC3819189.
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    141. Proteomic analysis of laser-captured paraffin-embedded tissues: a molecular portrait of head and neck cancer progression. Clin Cancer Res. 2008 Feb 15; 14(4):1002-14. Patel V, Hood BL, Molinolo AA, Lee NH, Conrads TP, Braisted JC, Krizman DB, Veenstra TD, Gutkind JS. PMID: 18281532.
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    142. Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature. J Biol Chem. 2008 Jan 04; 283(1):529-540. Liu S, Wang H, Currie BM, Molinolo A, Leung HJ, Moayeri M, Basile JR, Alfano RW, Gutkind JS, Frankel AE, Bugge TH, Leppla SH. PMID: 17974567; PMCID: PMC2394502.
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    143. Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice. J Biol Chem. 2007 Dec 14; 282(50):36714-23. List K, Currie B, Scharschmidt TC, Szabo R, Shireman J, Molinolo A, Cravatt BF, Segre J, Bugge TH. PMID: 17940283.
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    144. Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase. J Cell Physiol. 2007 Oct; 213(1):237-45. List K, Hobson JP, Molinolo A, Bugge TH. PMID: 17471493.
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    145. Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative. Clin Cancer Res. 2007 Sep 01; 13(17):4964-73. Molinolo AA, Hewitt SM, Amornphimoltham P, Keelawat S, Rangdaeng S, Meneses García A, Raimondi AR, Jufe R, Itoiz M, Gao Y, Saranath D, Kaleebi GS, Yoo GH, Leak L, Myers EM, Shintani S, Wong D, Massey HD, Yeudall WA, Lonardo F, Ensley J, Gutkind JS. PMID: 17785546.
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    146. Female mice are more susceptible to developing inflammatory disorders due to impaired transforming growth factor beta signaling in salivary glands. Arthritis Rheum. 2007 Jun; 56(6):1798-805. Nandula SR, Amarnath S, Molinolo A, Bandyopadhyay BC, Hall B, Goldsmith CM, Zheng C, Larsson J, Sreenath T, Chen W, Ambudkar IS, Karlsson S, Baum BJ, Kulkarni AB. PMID: 17530708.
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    147. TGF-beta receptor I conditional knockout mice develop spontaneous squamous cell carcinoma. Cell Cycle. 2007 Jun 01; 6(11):1360-6. Honjo Y, Bian Y, Kawakami K, Molinolo A, Longenecker G, Boppana R, Larsson J, Karlsson S, Gutkind JS, Puri RK, Kulkarni AB. PMID: 17534148.
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    148. Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells. Oncogene. 2007 Aug 02; 26(35):5078-85. Castilho RM, Squarize CH, Patel V, Millar SE, Zheng Y, Molinolo A, Gutkind JS. PMID: 17334398.
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    149. Association of estrogen receptor-alpha and progesterone receptor A expression with hormonal mammary carcinogenesis: role of the host microenvironment. Breast Cancer Res. 2007; 9(2):R22. Montero Girard G, Vanzulli SI, Cerliani JP, Bottino MC, Bolado J, Vela J, Becu-Villalobos D, Benavides F, Gutkind S, Patel V, Molinolo A, Lanari C. PMID: 17341305; PMCID: PMC1868922.
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    150. Increased expression of the collagen internalization receptor uPARAP/Endo180 in the stroma of head and neck cancer. J Histochem Cytochem. 2007 Apr; 55(4):347-53. Sulek J, Wagenaar-Miller RA, Shireman J, Molinolo A, Madsen DH, Engelholm LH, Behrendt N, Bugge TH. PMID: 17189524.
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    151. Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development. Oncogene. 2007 Mar 08; 26(11):1546-56. Szabo R, Molinolo A, List K, Bugge TH. PMID: 16983341.
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    152. The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. Cancer Cell. 2006 Aug; 10(2):133-43. Sodhi A, Chaisuparat R, Hu J, Ramsdell AK, Manning BD, Sausville EA, Sawai ET, Molinolo A, Gutkind JS, Montaner S. PMID: 16904612.
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    153. Natural and synthetic progestins accelerate 7,12-dimethylbenz[a]anthracene-initiated mammary tumors and increase angiogenesis in Sprague-Dawley rats. Clin Cancer Res. 2006 Jul 01; 12(13):4062-71. Benakanakere I, Besch-Williford C, Schnell J, Brandt S, Ellersieck MR, Molinolo A, Hyder SM. PMID: 16818706.
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    154. Delineation of matriptase protein expression by enzymatic gene trapping suggests diverging roles in barrier function, hair formation, and squamous cell carcinogenesis. Am J Pathol. 2006 May; 168(5):1513-25. List K, Szabo R, Molinolo A, Nielsen BS, Bugge TH. PMID: 16651618; PMCID: PMC1606590.
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    155. Rapid development of salivary gland carcinomas upon conditional expression of K-ras driven by the cytokeratin 5 promoter. Am J Pathol. 2006 May; 168(5):1654-65. Raimondi AR, Vitale-Cross L, Amornphimoltham P, Gutkind JS, Molinolo A. PMID: 16651631; PMCID: PMC1606594.
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    156. Fibroblast growth factor-2 expression during experimental oral carcinogenesis. Its possible role in the induction of pre-malignant fibrosis. J Oral Pathol Med. 2006 Apr; 35(4):212-7. Raimondi AR, Molinolo AA, Itoiz ME. PMID: 16519768.
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    157. Precancer in mice: animal models used to understand, prevent, and treat human precancers. Toxicol Pathol. 2006; 34(6):699-707. Cardiff RD, Anver MR, Boivin GP, Bosenberg MW, Maronpot RR, Molinolo AA, Nikitin AY, Rehg JE, Thomas GV, Russell RG, Ward JM. PMID: 17074738.
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    158. Involvement of matrix metalloproteinase activity in hormone-induced mammary tumor regression. Am J Pathol. 2006 Jan; 168(1):270-9. Simian M, Molinolo A, Lanari C. PMID: 16400029; PMCID: PMC1592671.
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    159. Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation. Stem Cells. 2006 Apr; 24(4):1095-103. Miura M, Miura Y, Padilla-Nash HM, Molinolo AA, Fu B, Patel V, Seo BM, Sonoyama W, Zheng JJ, Baker CC, Chen W, Ried T, Shi S. PMID: 16282438.
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    160. Antisense oligonucleotides targeting the progesterone receptor inhibit hormone-independent breast cancer growth in mice. Breast Cancer Res. 2005; 7(6):R1111-21. Lamb CA, Helguero LA, Giulianelli S, Soldati R, Vanzulli SI, Molinolo A, Lanari C. PMID: 16457691; PMCID: PMC1410760.
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    161. Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck. Cancer Res. 2005 Nov 01; 65(21):9953-61. Amornphimoltham P, Patel V, Sodhi A, Nikitakis NG, Sauk JJ, Sausville EA, Molinolo AA, Gutkind JS. PMID: 16267020.
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    162. Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation. Genes Dev. 2005 Aug 15; 19(16):1934-50. List K, Szabo R, Molinolo A, Sriuranpong V, Redeye V, Murdock T, Burke B, Nielsen BS, Gutkind JS, Bugge TH. PMID: 16103220; PMCID: PMC1186192.
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    163. Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy. J Cell Biol. 2005 Jun 20; 169(6):977-85. Curino AC, Engelholm LH, Yamada SS, Holmbeck K, Lund LR, Molinolo AA, Behrendt N, Nielsen BS, Bugge TH. PMID: 15967816; PMCID: PMC2171632.
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    164. Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells. Mol Cell Biol. 2005 Jun; 25(12):4826-40. Proietti C, Salatino M, Rosemblit C, Carnevale R, Pecci A, Kornblihtt AR, Molinolo AA, Frahm I, Charreau EH, Schillaci R, Elizalde PV. PMID: 15923602; PMCID: PMC1140598.
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    165. Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin. Nat Biotechnol. 2005 Jun; 23(6):725-30. Liu S, Redeye V, Kuremsky JG, Kuhnen M, Molinolo A, Bugge TH, Leppla SH. PMID: 15895075; PMCID: PMC2405912.
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    166. Estrogen or antiprogestin treatment induces complete regression of pulmonary and axillary metastases in an experimental model of breast cancer progression. Carcinogenesis. 2005 Jun; 26(6):1055-63. Vanzulli SI, Soldati R, Meiss R, Colombo L, Molinolo AA, Lanari C. PMID: 15774491.
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    167. Isolation of a stromal cell line from an early passage of a mouse mammary tumor line: a model for stromal parenchymal interactions. J Cell Physiol. 2005 Mar; 202(3):672-82. Lamb CA, Fabris V, Gorostiaga MA, Helguero LA, Efeyan A, Bottino MC, Simian M, Soldati R, Sanjuan N, Molinolo A, Lanari C. PMID: 15389583.
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    168. Proteome-wide analysis of head and neck squamous cell carcinomas using laser-capture microdissection and tandem mass spectrometry. Oral Oncol. 2005 Feb; 41(2):183-99. Baker H, Patel V, Molinolo AA, Shillitoe EJ, Ensley JF, Yoo GH, Meneses-García A, Myers JN, El-Naggar AK, Gutkind JS, Hancock WS. PMID: 15695121.
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    169. Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis. Cancer Res. 2004 Dec 15; 64(24):8804-7. Vitale-Cross L, Amornphimoltham P, Fisher G, Molinolo AA, Gutkind JS. PMID: 15604235.
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    170. Detection of plasminogen activators in oral cancer by laser capture microdissection combined with zymography. Oral Oncol. 2004 Nov; 40(10):1026-32. Curino A, Patel V, Nielsen BS, Iskander AJ, Ensley JF, Yoo GH, Holsinger FC, Myers JN, El-Nagaar A, Kellman RM, Shillitoe EJ, Molinolo AA, Gutkind JS, Bugge TH. PMID: 15509494.
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    171. Global gene expression profile of nasopharyngeal carcinoma by laser capture microdissection and complementary DNA microarrays. Clin Cancer Res. 2004 Aug 01; 10(15):4944-58. Sriuranpong V, Mutirangura A, Gillespie JW, Patel V, Amornphimoltham P, Molinolo AA, Kerekhanjanarong V, Supanakorn S, Supiyaphun P, Rangdaeng S, Voravud N, Gutkind JS. PMID: 15297395.
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    172. Inhibition of in vivo breast cancer growth by antisense oligodeoxynucleotides to type I insulin-like growth factor receptor mRNA involves inactivation of ErbBs, PI-3K/Akt and p42/p44 MAPK signaling pathways but not modulation of progesterone receptor activity. Oncogene. 2004 Jul 01; 23(30):5161-74. Salatino M, Schillaci R, Proietti CJ, Carnevale R, Frahm I, Molinolo AA, Iribarren A, Charreau EH, Elizalde PV. PMID: 15122317.
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    173. Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01. Clin Cancer Res. 2004 Jun 15; 10(12 Pt 1):4029-37. Amornphimoltham P, Sriuranpong V, Patel V, Benavides F, Conti CJ, Sauk J, Sausville EA, Molinolo AA, Gutkind JS. PMID: 15217935.
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    174. Establishment of two hormone-responsive mouse mammary carcinoma cell lines derived from a metastatic mammary tumor. Breast Cancer Res Treat. 2004 Feb; 83(3):233-44. Efeyan A, Fabris V, Merani S, Lanari C, Molinolo AA. PMID: 14758093.
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    175. Progesterone receptor expression in medroxyprogesterone acetate-induced murine mammary carcinomas and response to endocrine treatment. Breast Cancer Res Treat. 2003 Jun; 79(3):379-90. Helguero LA, Viegas M, Asaithamby A, Shyamala G, Lanari C, Molinolo AA. PMID: 12846422.
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    176. Differential effects of raloxifene, tamoxifen and fulvestrant on a murine mammary carcinoma. Breast Cancer Res Treat. 2003 May; 79(1):25-35. Lamb CA, Helguero LA, Fabris V, Lucas C, Molinolo AA, Lanari C. PMID: 12779079.
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    177. Evidence for two progesterone receptor binding sites in murine mammary carcinomas. J Steroid Biochem Mol Biol. 2003 Jan; 84(1):9-14. Helguero LA, Lamb C, Molinolo AA, Lanari C. PMID: 12648519.
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    178. Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Cancer Cell. 2003 Jan; 3(1):23-36. Montaner S, Sodhi A, Molinolo A, Bugge TH, Sawai ET, He Y, Li Y, Ray PE, Gutkind JS. PMID: 12559173.
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    179. Progesterone receptors--animal models and cell signalling in breast cancer. Diverse activation pathways for the progesterone receptor: possible implications for breast biology and cancer. Breast Cancer Res. 2002; 4(6):240-3. Lanari C, Molinolo AA. PMID: 12473170; PMCID: PMC137940.
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    180. p21, p27 and p53 in estrogen and antiprogestin-induced tumor regression of experimental mouse mammary ductal carcinomas. Carcinogenesis. 2002 May; 23(5):749-58. Vanzulli S, Efeyan A, Benavides F, Helguero LA, Peters G, Shen J, Conti CJ, Lanari C, Molinolo A. PMID: 12016147.
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    181. Protective role of medroxyprogesterone acetate on N-methyl-N-nitrosourea-induced lymphomas in BALB/c female mice. Leuk Res. 2001 Feb; 25(2):165-7. Pazos P, Lanari C, Molinolo AA. PMID: 11166832.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    182. Regulation of cell growth of a progestin-dependent murine mammary carcinoma in vitro: progesterone receptor involvement in serum or growth factor-induced cell proliferation. J Steroid Biochem Mol Biol. 1999 Sep-Oct; 70(4-6):133-42. Lamb C, Simian M, Molinolo A, Pazos P, Lanari C. PMID: 10622401.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    183. Reversal of estrogen-resistance in murine mammary adenocarcinomas. Breast Cancer Res Treat. 1999 Mar; 54(2):93-9. Montecchia MF, Molinolo A, Lanari C. PMID: 10424399.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    184. Progesterone receptor involvement in independent tumor growth in MPA-induced murine mammary adenocarcinomas. J Steroid Biochem Mol Biol. 1999 Jan; 68(1-2):11-21. Montecchia MF, Lamb C, Molinolo AA, Luthy IA, Pazos P, Charreau E, Vanzulli S, Lanari C. PMID: 10215033.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    185. Involvement of insulin-like growth factors-I and -II and their receptors in medroxyprogesterone acetate-induced growth of mouse mammary adenocarcinomas. J Steroid Biochem Mol Biol. 1998 Nov; 67(4):305-17. Elizalde PV, Lanari C, Molinolo AA, Guerra FK, Balañá ME, Simian M, Iribarren AM, Charreau EH. PMID: 9883987.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    186. Involvement of EGF in medroxyprogesterone acetate (MPA)-induced mammary gland hyperplasia and its role in MPA-induced mammary tumors in BALB/c mice. Cancer Lett. 1998 Apr 10; 126(1):49-57. Molinolo A, Simian M, Vanzulli S, Pazos P, Lamb C, Montecchia F, Lanari C. PMID: 9563648.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    187. Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice. Carcinogenesis. 1998 Mar; 19(3):529-31. Pazos P, Lanari C, Elizalde P, Montecchia F, Charreau EH, Molinolo AA. PMID: 9525291.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    188. [Progestin-induced mammary adenocarcinomas in BALB/c mice. Progression from hormone-dependent to autonomous tumors]. Medicina (B Aires). 1997; 57 Suppl 2:55-69. Lanari C, Montecchia MF, Pazos P, Simian M, Vanzulli S, Lamb C, Molinolo AA. PMID: 9567344.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    189. Effect of medroxyprogesterone acetate (MPA) and serum factors on cell proliferation in primary cultures of an MPA-induced mammary adenocarcinoma. Breast Cancer Res Treat. 1995 Aug; 35(2):173-86. Dran G, Luthy IA, Molinolo AA, Montecchia F, Charreau EH, Pasqualini CD, Lanari C. PMID: 7647339.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    190. Autoradiographic evaluation of radiolabeled monoclonal antibody B72.3 distribution in tumor and lymph nodes of adenocarcinoma patients. Anticancer Res. 1995 May-Jun; 15(3):975-84. Roselli M, Hitchcock CL, Molinolo A, Milenic DE, Colcher D, Martin EW, Hinkle GH, Schlom J. PMID: 7645989.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    191. Effect of sialoadenectomy on medroxyprogesterone-acetate-induced mammary carcinogenesis in BALB/c mice. Correlation between histology and epidermal-growth-factor receptor content. Int J Cancer. 1994 Oct 15; 59(2):196-203. Kordon EC, Guerra F, Molinolo AA, Elizalde P, Charreau EH, Pasqualini CD, Montecchia F, Pazos P, Dran G, Lanari C. PMID: 7927919.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    192. Progesterone induction of mammary carcinomas in BALB/c female mice. Correlation between progestin dependence and morphology. Breast Cancer Res Treat. 1993 Oct; 28(1):29-39. Kordon EC, Molinolo AA, Pasqualini CD, Charreau EH, Pazos P, Dran G, Lanari C. PMID: 8123867.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    193. Re: Oral contraceptives and breast cancer. J Natl Cancer Inst. 1993 Sep 15; 85(18):1525. Lanari C, Molinolo AA, Pasqualini CD. PMID: 8360937.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    194. [Progesterone and breast cancer]. Medicina (B Aires). 1993; 53(3):276-7. Lanari C, Molinolo AA, Dosne Pasqualini C. PMID: 8114637.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    195. Intraperitoneal administration of interferon-gamma to carcinoma patients enhances expression of tumor-associated glycoprotein-72 and carcinoembryonic antigen on malignant ascites cells. J Clin Oncol. 1992 May; 10(5):735-46. Greiner JW, Guadagni F, Goldstein D, Smalley RV, Borden EC, Simpson JF, Molinolo A, Schlom J. PMID: 1569446.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    196. Therapeutic advantage of high-affinity anticarcinoma radioimmunoconjugates. Cancer Res. 1992 Mar 01; 52(5):1067-72. Schlom J, Eggensperger D, Colcher D, Molinolo A, Houchens D, Miller LS, Hinkle G, Siler K. PMID: 1310638.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    197. Estrogen inhibition of MPA-induced mouse mammary tumor transplants. Int J Cancer. 1991 Dec 02; 49(6):900-5. Kordon E, Lanari C, Molinolo AA, Elizalde PV, Charreau EH, Dosne Pasqualini C. PMID: 1835715.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    198. Progesterone receptors in estrogen-induced fibromatosis of guinea pigs. Cancer Lett. 1990 Jun 15; 51(3):235-45. Lanari C, Molinolo AA, Kordon E, Pasualini CD, Charreau EH. PMID: 2350763.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    199. Advantage of dose fractionation in monoclonal antibody-targeted radioimmunotherapy. J Natl Cancer Inst. 1990 May 02; 82(9):763-71. Schlom J, Molinolo A, Simpson JF, Siler K, Roselli M, Hinkle G, Houchens DP, Colcher D. PMID: 2182892.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    200. Enhanced tumor binding using immunohistochemical analyses by second generation anti-tumor-associated glycoprotein 72 monoclonal antibodies versus monoclonal antibody B72.3 in human tissue. Cancer Res. 1990 Feb 15; 50(4):1291-8. Molinolo A, Simpson JF, Thor A, Schlom J. PMID: 2297774.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    201. Mammary adenocarcinomas induced by medroxyprogesterone acetate: hormone dependence and EGF receptors of BALB/c in vivo sublines. Int J Cancer. 1989 May 15; 43(5):845-50. Lanari C, Kordon E, Molinolo A, Pasqualini CD, Charreau EH. PMID: 2523869.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    202. Studies concerning the effect of external irradiation on localization of radiolabeled monoclonal antibody B72.3 to human colon carcinoma xenografts. Int J Radiat Oncol Biol Phys. 1989 Mar; 16(3):721-9. Shrivastav S, Schlom J, Raubitschek A, Molinolo A, Simpson J, Hand PH. PMID: 2921170.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    203. Generation and characterization of B72.3 second generation monoclonal antibodies reactive with the tumor-associated glycoprotein 72 antigen. Cancer Res. 1988 Aug 15; 48(16):4588-96. Muraro R, Kuroki M, Wunderlich D, Poole DJ, Colcher D, Thor A, Greiner JW, Simpson JF, Molinolo A, Noguchi P, et al. PMID: 3396010.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
    204. Mouse mammary tumors induced by medroxyprogesterone acetate: immunohistochemistry and hormonal receptors. J Natl Cancer Inst. 1987 Dec; 79(6):1341-50. Molinolo AA, Lanari C, Charreau EH, Sanjuan N, Pasqualini CD. PMID: 2826865.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    205. Induction of mammary adenocarcinomas by medroxyprogesterone acetate in BALB/c female mice. Cancer Lett. 1986 Nov; 33(2):215-23. Lanari C, Molinolo AA, Pasqualini CD. PMID: 2947675.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    206. Inhibitory effect of medroxyprogesterone acetate on foreign body tumorigenesis in mice. J Natl Cancer Inst. 1986 Jul; 77(1):157-64. Lanari C, Molinolo AA, Pasqualini CD. PMID: 3522997.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    207. Demonstration of cytokeratins by immunoperoxidase staining in prostatic tissue. J Urol. 1985 Nov; 134(5):1037-40. Molinolo AA, Meiss RP, Leo P, Sens AI. PMID: 2414467.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    208. Plasma cell granuloma of the bladder: a case report. J Urol. 1984 Jun; 131(6):1175-6. Jufe R, Molinolo AA, Fefer SA, Meiss RP. PMID: 6726924.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
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